49 results about "Poor compliance" patented technology

The invention discloses a medicinal composition containing an insoluble alpha-receptor retardant and / or 5alpha-reductase inhibitor with an effective dose, which comprises the following components of: principal ingredients, a substrate, a solubilizer, a sorbefacient and an additive in a weight ratio of 1:(8-7,000):(0-460):(0-150):(0-150), wherein the medicinal composition at least contains one of the solubilizer and the sorbefacient. The effective dose of the insoluble alpha-receptor retardant and / or the 5alpha-reductase inhibitor is in 0.05 to 80 milligrams of parent compounds of the insoluble alpha-receptor retardant and / or the 5alpha-reductase inhibitor, the weight of a preparation per unit is between 0.8 and 4.2 grams. The medicinal composition can be subjected to oral administration or rectum administration, so the defects of poor curative effect and large toxic and side effect in the conventional oral administration and systemic administration of injection and large side effect and poor compliance of patients in local injection administration can be overcome, the lasting time of the medicinal effect can be increased, and better treatment means can be provided for medical care personnel and patients; and a product process is simple and is suitable for industrial batch production.

The invention discloses an anesthetic nasal spray and a preparation method thereof. The anesthetic nasal spray can be used for overcoming local anesthesia injection pain in a minor operation of an adult outpatient clinic, can fully solve the problems of preoperative and intraoperative tension, poor compliance and poor sensitivity; the anesthetic nasal spray is prepared from, by weight, 3-5 ml of adexmedetomidine hydrochloride injection, 0.5-2 ml of a sufentanil citrate injection and 8-10 ml of normal saline. The preparation method of the anesthetic nasal spray comprises the following steps that a, the dexmedetomidine hydrochloride injection is sucked by a medical syringe A; b, the sufentanil citrate injection is sucked by a medical syringe B; c, the normal saline is sucked by the medicalsyringe B to dilute the sufentanil citrate injection; d, the liquids in the medical syringe A and medical syringe B are mixed, and then standing is performed for 3-10 minutes.

The invention relates to a triamcinolone acetonide acetate sustained release microsphere and a preparation method thereof. The method comprises the following steps that triamcinolone acetonide acetate and a degradable polymer with a hydrophobic chain segment are dissolved in an organic solvent, and a polymer solution with drugs is obtained; under the stirring condition, the polymer solution with drugs is added to a water phase to form an O / W emulsion, and the organic solvent in the emulsion is removed; the water phase contains a stabilizer, and the proportion of the stabilizer to the water phase is 0.1-5% (w / v); under the stirring condition, the obtained dispersion system is added into water for solidification, and the triamcinolone acetonide acetate sustained release microsphere is obtained. The triamcinolone acetonide acetate sustained release microsphere is proper in particle diameter, round in shape, high in encapsulation efficiency and good in drug loading capacity, and the problems of short release time of a preparation and poor compliance of a patient can be effectively solved.

The invention belongs to the field of medicinal preparations, and relates to liposome for eyes and a preparation method thereof. In order to overcome the defects that common eye drops have short residence time in the conjunctival sac to cause low bioavailability at the eyes and the semi-solid dosage form has poor compliance and is not easy to be accepted by patients and the like in the prior art,the invention provides a biological adhesive liposome preparation for eyes. The biological adhesive liposome preparation for the eyes consists of the liposome, a liposome membrane modification material and a medicament wrapped in the liposome, wherein the surface of the liposome is modified with free mercapto, and a covalent binding disulfide bond can be formed by the free mercapto and a mucoprotein subdomain rich in cysteine on the surface of the eye to anchor the liposome on the surface of a mucous membrane and serve as a medicament store to slowly release the medicament in the conjunctivalsac and provide permanent driving force for the absorption of the medicament. The preparation is helpful for promoting the absorption of the medicament at the eyes, and can improve the bioavailabilityof the medicament.

The invention discloses application of L-fucose in medicines and health-care products for treating gastrointestinal lesions. The L-fucose is used for treating the gastrointestinal lesions, such as inflammatory bowel disease, functional gastrointestinal disorder and irritable bowel syndrome. The medicine is a carbohydrate medicine, since the adverse effect is less, and the tolerance of a patient is good, so that the medicine can be widely applied into clinic. The medicine has the advantages that the L-fucose is used in an early period of the gastrointestinal lesions, the activation of mesenteric lymph node Treg cells is regulated by DC cells, the differentiation potential of colons Th1 and Th17 is inhibited, the generation of bile acid is inhibited by regulating the intestinal flora, the function of inhibiting the contraction and spasm of intestinal muscles is realized by an nNOS path, the intestinal inflammation and weight-losing conditions are improved, and the patient can obtain an obvious long-term prognosis benefit; because of limitations of related existing therapy medicines, namely multiple medicine types, large side effect and poor compliance, a new therapy strategy for treating the patients with the gastrointestinal lesions, such as the inflammatory bowel disease, the functional gastrointestinal disorder and the irritable bowel syndrome, is provided.

Current medication labels are very difficult for people with disabilities, language barriers, functional impairments, or illiteracy to read, potentially increasing the risk for accidental medication overdoses and / or poor compliance with medication administration and adherence. By having a color coded sticker system with an enclosed full body guide in the form of a poster, and a home health medication record card, these stickers are placed on each medication bottle as a symbol for what the medication is used for. The stickers are color coded in order to distinguish the time the medication is to be administered. Home health agencies may use the poster and stickers as they educate their patients about the medications they take.

The invention discloses application of a circ_SLC7A5 molecular marker in blood in diagnosing esophageal squamous carcinoma and prognosis, and relates to discovery, detection and application of the circ_SLC7A5 molecular marker. A specific detection primer for real-time quantitative PRC is designed and synthesized. Circ_SLC7A5 in the blood can serve as a plasma marker for ESCC patients, aiming at the status quo that a target group of people have poor compliance on esophagus cancer endoscope screening, and most of esophageal squamous carcinoma patients with definite diagnosis in clinic are in themiddle and advanced stage, ideal molecular early-warning signals are found out in the esophagus squamous cell canceration process, endoscopy is targetedly carried out, the pathology is conformed, sothat the pain of the patients is alleviated, excessive medical treatment is avoided, and medical resources are saved.

The invention relates to compound gel for treating glaucoma and a preparation method thereof, effectively solving the problems of serious side effect, poor compliance, low bioavailability and serious irritation in the prior art. According to the technical scheme, the gel comprises the following components in percentage by weight: 1.0-4.0 percent of brinzolamide-resin compound, 10-40 percent of gel substrate, 0.1-20 percent of suspending agent, 0.001-0.02 percent of preservative, 0.1-10 percent of osmotic pressure regulator, 0.1-10 percent of pH regulator, and 30-70 percent of pharmaceutical water solution. The compound gel overcomes the defects that cream makes vision unclear and the dose of traditional gel is hard to control, is capable of prolonging the staying time of medicine on the surface of cornea, improving the bioavailability of the medicine in eyes and increasing the compliance of patients, and is an innovation in the field of medicine for treating glaucoma.

The invention relates to a medicine composition, in particular to the medicine composition containing tirofian and active antithrombotic component. The active components are the tirofiban and aspirin. The medicine composition contains 1 to 50mg of the tirofiban and the aspirin with 20 to 800mg of effective dose. Compared with using the tirofiban or the aspirin separately, the blooding time of the invention is prolonged, so the occurrence rate of blooding and thrombus is reduced. In addition, the medicine composition solves a problem that the medicine is difficult to be taken orally for the part of high-risk ACS patients who can not take the medicine orally or have poor compliance. Therefore, the medicine composition is beneficial to improving the compliance of the patients and the safe use of the medicine, etc.

The invention belongs to the field of pharmaceutical preparations, and relates to a series multivalent cell-penetrating peptide delivery vector and a complex thereof, wherein the vector is built by the aid of multi-arm polyethylene glycol and cell-penetrating peptides or cell-penetrating peptide derivatives. The multivalent cell-penetrating peptide delivery vector has an octopus-like flexible structure, can be self-assembled with biological macromolecules, particularly genes to form the non-covalent complex and has strong biological macromolecule carrying, biological macromolecule delivery andocular tissue penetrating capacity, ocular tissue toxicity is avoided, biological macromolecule drugs can be effectively delivered to an intraocular portion or ocular fundus in a noninvasive way, andbiological macromolecule drug uptake by ocular tissues is increased. The complex formed by self-assembling the multivalent cell-penetrating peptide delivery vector with the biological macromoleculescan be used for eye drop administration, intraocular injection administration with poor compliance to patients can be replaced, and intraocular and ocular fundus disease treatment convenience and safety are enhanced.

The invention discloses an inflammation-diminishing and skin-reproducing oil gauze for treating diabetic feet and a preparation method of the oil gauze. The oil gauze is prepared from the traditional Chinese medicines (coptidis rhizome, cortex phellodendri, scutellaria baicalensis, sanguisorba officinalis and angelica sinensis), which are relatively effective on the diabetic feet in combination. An experiment proves that the inflammation-diminishing and skin-reproducing oil gauze is good in curative effect, free of drug tolerance, free of adverse reaction, economical, practical, convenient to use, and easy to popularize; the compliance and the curative effect on treatment of the diabetic feet can be improved; and the problems of high investment, expensive consumable items, high technical requirements, large economic burden on patients, and poor compliance in application of expensive dressing and closed negative pressure treatment are avoided.

The invention relates to a preparation method of granisetron sustained-release microspheres. The method comprises the following steps: dissolving granisetron and a degradable polymer containing a hydrophobic chain segment in an organic solvent to obtain a drug-containing polymer solution; adding the drug-containing polymer solution to an aqueous phase with stirring to form O / W emulsion, and removing the organic solvent from the emulsion, wherein the aqueous phase contains a stabilizer, and the ratio of the stabilizer to the aqueous phase is 0.1-5% (w / v); and adding the obtained dispersion system into water for solidification under the condition of stirring to obtain the granisetron sustained-release microspheres. The granisetron sustained-release microspheres disclosed by the invention aresuitable in particle size, round in shape, high in encapsulation rate, good in drug loading rate, free from sudden release phenomenon, and capable of effectively solving the problems of short releasetime of a preparation and poor compliance of a patient.

The invention discloses traditional Chinese medicine lotion for the bronchitis of an infant and a preparation method thereof. The medicine is prepared by combining a traditional recipe of traditional Chinese medicines comprising maxingshigaotang, xiaoqinglongtang and erchentang, a proved recipe (houttuynia cordata, Chinese ephedra, poncirus trifoliata, radix platycodi and licorice) for the bronchitis of an infant and traditional Chinese medicines (peach kernel, angelica and herba epimedii) which are comparatively effective to the bronchitis of the infant. Experiments prove that the traditional Chinese medicine lotion for the bronchitis of the infant has a good curative effect, no drug resistance and no adverse reaction, is economical and practical, is convenient to use, is easy to popularize and can be used for enhancing the compliance and the curative effect of the treatment of the bronchitis of the infant and avoiding the problems of poor compliance and risk in the drug resistance, which exist in the treatment of oral administration of traditional Chinese medicines and intravenous injection of antibiotics.

The invention relates to bacillus CCPM7650 with strong anticancer activity and application thereof, and belongs to the technical field of biopharmaceuticals. In order to solve the problem of large side effects of existing anticancer drugs, the bacillus CCPM7650 with strong anticancer activity is provided, belongs to bacillus, and is preserved in the China General Microbiological Culture Collection Center with the preservation number of CGMCC No.17113; the strain is derived from the intestinal tract of the human body, is a kind of newly-discovered bacillus, and can produce anticancer active metabolites, and the metabolites of the strain can be utilized for treating cancers. Since the strain is discovered in the intestinal tract of the human body, the strain has low or no side effects on the human body, solves the problems of large side effects, poor compliance to patients and the like of the existing anticancer drugs, and is expected to achieve the purpose of preventing the cancers by adjusting the balance of intestinal florae.

The invention belongs to the field of health-care products, and particularly relates to a health-care tea for degrading blood lipid and blood pressure. The health-care tea is prepared from the following components in parts by weight: 500 to 900 parts of Puer sun-withering raw tea, 30 to 65 parts of sticktight herb, 20 to 76 parts of herba agrimoniae, 10 to 35 parts of herba apocynum venetum, 15 to 30 parts of radix polygalae, 20 to 38 parts of fructus schisandrae, and 5 to 18 parts of herba clerodendranthi. The invention also relates to a preparation method of the health-care tea. The preparation method comprises the following steps of weighing the components (except Puer sun-withering raw tea) in parts by weight, and crushing; utilizing an anti-oxidizing liquid to extract, so as to obtain an extracting liquid; spraying the extracting liquid onto the Puer sun-withering raw tea, composting and fermenting, so as to finally prepare the health-care tea for decreasing the blood lipid and the blood pressure. The health-care tea has the advantages that the function of degreasing blood lipid and blood pressure is realized, and the effect of degreasing blood lipid and blood pressure is obvious; the health-care tea can be used as a common beverage to drink, and the problem of poor compliance of the patient with high blood lipid and high blood pressure when taking medicine is solved.

A dry suspension of salivamol and a preparation method thereof relate to the technical field of medicine. First, salivamol, a flavoring suspending agent, and a filler are respectively pulverized and passed through a 100-120 mesh sieve; then salivamol, Filler, suspending agent, flavoring agent and binder solution are mixed and granulated, then dried at 55±5°C; then packaged. The process of the invention is simple and reasonable, convenient for production, beneficial to low energy consumption, low-cost production, and good product stability. The invention adopts a new type of auxiliary material, sodium carboxymethyl cellulose and microcrystalline cellulose. After the product is added with water, it can quickly form a uniformly distributed suspension. The product has a sweet smell. After taking it, the human body hardly absorbs it. High concentration, low incidence of adverse reactions, and mild. The invention expands the application range of salaminol, and makes up for the defect of poor compliance of patients taking solid preparations.

The invention discloses a device for expanding a maxillary dental arch through automatic force application. The device comprises a support, force application rods, a driving mechanism and a guide mechanism, wherein the force application rods are slidably connected with the guide mechanism, the guide mechanism and the driving mechanism make the force application rods horizontally move towards the outer side or the inner side of the support, the guide mechanism is fixedly arranged on the support, the output end of the driving mechanism is connected with the force input ends of the force application rods, the force application rods are arranged at the two sides of the support, and the guide mechanism and the driving mechanism make the force application rods horizontally move towards the outer side or the inner side of the support; and the guide mechanism comprises a guide rail and a guide sliding block, and the sliding block is slidably arranged on the guide rail and is also connected with the output ends of the force application rods and the output end of the driving mechanism. Automatic force application of an arch expander can be achieved, and the situation is avoided that the treatment progress and effect are influenced due to poor compliance of a patient; force application parameters can be adjusted according to the condition of the patient, and the comfort of the patient in the treatment process can be improved through single small-distance and high-frequency force application; and improvement from traditional maxillary arch expansion to high implementation rate increase is achieved to ensure the clinical arch expansion effect.

The invention provides a hearing aid based on a 4D printing shape memory material. The hearing aid comprises a hearing aid main body, a protective cover covers the outside of the hearing aid main body, the protective cover is made of a 4D printing shape memory polymer or a 4D printing shape memory polymer composite material, and the protective cover is expanded under a body temperature condition,until the shape completely conforms to an inner wall of a bone groove and does not change. According to the hearing aid based on the 4D printing shape memory material provided by the invention, the protective cover made of the 4D printing shape memory material is arranged at the outside of the hearing aid main body, so that a hearing aid device is tightly fitted with the skull to reduce the weightat a mastoid joint, the self-tightening of the hearing aid device and the skull is achieved, especially for children with poor compliance, the operation prognosis is better, and since the main structure of the hearing aid device is isolated internally and is not in direct contact with human tissues, the requirements for the material of the device are reduced, thereby reducing the cost of the hearing aid device.

The invention discloses serrate rabdosia herb black tea solid beverage as well as a preparation method and application thereof. The solid beverage is prepared from the main raw materials of a serraterabdosia herb extracting solution and a black tea extracting solution. The prepared serrate rabdosia herb black tea solid beverage disclosed by the invention has fresh and gentle taste and sufficientblack tea fragrance; the black tea taste can neutralize bitterness and cold and cool characteristics of the serrate rabdosia herb, so that the solid tea beverage has fresher taste and gentler character. A product of the serrate rabdosia herb black tea solid beverage has excellent effects of improving the blood lipid level and protecting the liver and is suitable for being used as daily health-carebeverage of obesity, high blood pressure, high blood sugar, high blood fat and obesity type fatty liver people; the solid beverage does not contain a sugar ingredient, can effectively prevent excessive sugar intake, has small side effect and is healthier to drink; meanwhile, the product is in a solid type, is easy to carry, has convenience in daily drinking and overcomes the problems of poor compliance of a patient to take medicine.

The invention provides a preparation method of pseudo-ginseng dysmenorrhea dispersible tablets, relates to a preparation method of dysmenorrhea medicinal dispersible tablets, and aims at solving technical problems of slow disintegrating release, low bioavailability and poor compliance of a conventional pseudo-ginseng medicament. The preparation method comprises the following steps of: 1, weighing raw materials in parts by mass; 2, preparing pseudo-ginseng dry extract powder; 3, preparing raw material medicinal powder; 4, preparing mixed powder; and 5, preparing pseudo-ginseng dymenorrhea dispersible tablets. The pseudo-ginseng dysmenorrhea dispersible tablets prepared by the method are good in stability and high in oral bioavailability, have small hygroscopicity in the preparing process, do not require coating, are quick in disintegration and absorption, and can quickly relieve various symptoms caused by dysmenorrhea. The preparation method is applicable to the field of dysmenorrhea medicament preparation.

The invention discloses application of a circ_SLC7A5 molecular marker in blood in diagnosing esophageal squamous carcinoma and prognosis, and relates to discovery, detection and application of the circ_SLC7A5 molecular marker. A specific detection primer for real-time quantitative PRC is designed and synthesized. Circ_SLC7A5 in the blood can serve as a plasma marker for ESCC patients, aiming at the status quo that a target group of people have poor compliance on esophagus cancer endoscope screening, and most of esophageal squamous carcinoma patients with definite diagnosis in clinic are in themiddle and advanced stage, ideal molecular early-warning signals are found out in the esophagus squamous cell canceration process, endoscopy is targetedly carried out, the pathology is conformed, sothat the pain of the patients is alleviated, excessive medical treatment is avoided, and medical resources are saved.

The invention relates to dry powder inhalers, in particular to dry powder inhalers prepared from bufotalin, a preparation method of the dry powder inhalers and application of the dry powder inhalers to preparation of medicaments for treating lung tumor medicaments. The bufotalin dry powder inhalers are characterized by consisting of bufotalin and a medically acceptable auxiliary material according to the mass ratio of (1:0.05)-(1:115). The bufotalin is prepared into the dry powder inhalers which can directly act on a focus of lung, so that toxic or side reaction is reduced, bioavailability ofthe medicament is improved, the defects of slow response, hepatic first-pass effect, systemic toxic or side effect, low bioavailability and the like of an oral preparation can be overcome, meanwhile,the problems of inconvenience for use, poor compliance of a patient and the like of injection can also be solved. Thus, the method of preparing the bufotalin into the dry powder inhalers has broad prospect on development of new medicaments.

The invention discloses a gastrodine solid dispersible tablet preparation, which contains the components in percentage by weight as follows: 25% of gastrodine,20-30% of enteric solubility carrier material,25-30% of water soluble carrier material,7-17% of conglutinate agent,and 3-13% of flow aid. The invention also discloses a preparation method of the gastrodine solid dispersible tablet preparation. The gastrodine solid dispersible tablet disclosed by the invention improves the defects of poor taste poor compliance, and low bioavailability of gastrodine oral preparation. The preparation technology research of the modern solid dispersive technique of gastrodine solves the defects, the medicine bioavailability is improved, the target is strengthened, slow release function is provided, thus the therapeutic action of gastrodine is played fully, the method is simple to operate, has good reproducibility, is easy to realize mass production, also in vivo slow release of gastrodine is controlled by optimizing the proportioning of the enteric solubility carrier material and the water soluble carrier material, and the aim of exerting curative effect preferably is achieved.

The invention discloses antibacterial anti-virus hand cream and a preparation method thereof. The hand cream is prepared from the raw materials including a silver ion-amino group ligand compound solution, ethanol, emulsion stabilizer, a non-ionic surfactant, a lichen extract, glycerine, water and the like, wherein in the silver ion-amino group ligand compound solution, the proportion of silver ion and amino groups is 1 to 3, and the molar volume ratio of the silver ion to the silver ion-amino group ligand compound solution is 1 to (10000 to 100000). The hand cream adopted by the invention integrates effects of resisting bacteria, resisting virus and protecting skin; after hand-washing, the hand cream is sterilized without using a disinfectant, and the hand cream is directly applied to the hands to play an antibacterial effect, so that the hand cream is convenient to use and the bactericidal and antibacterial activity can be maintained for a long time; an antibacterial effect can be maintained for not less than 3 hours, so that nosocomial infection caused by poor compliance of hand washing is reduced.

The invention relates to an ironing acupuncture gourd. The ironing acupuncture gourd is filled with ironing acupuncture medicine liquid. A gourd shell of the ironing acupuncture gourd is soaked in theironing acupuncture medicine liquid; the ironing acupuncture medicine liquid comprises compositions A or compositions B, the compositions A comprise folium artemisiae argyi, herba portulacae, pericarpium zanthoxyli, herba speranskiae tuberculatae, flos carthami and salt, and the compositions B comprise cortex dictamni, radix angelicae sinensis, radix saposhnikoviae and radix glycyrrhizae. The ironing acupuncture gourd has the advantages that the ironing acupuncture gourd can be used without being delivered through the mouths and the tongues, and the problem of poor compliance of traditional Chinese medicine decoction or Chinese patent medicines can be solved.

The invention relates to a preparation for a vascular graft with anti-thrombosis and anti-platelet adhesiveness potentials and belongs to the field of medical biological materials. The invention aimsto solve the problems of limited autologous blood vessels and complex operation, high risk of allogeneic blood vessels, poor compliance or calcification of high polymer materials implanted to body, and the like, in clinics at present. The vascular graft is prepared through the following steps: planting autologous histocytes of receptor in three layers according to the characteristics of differentstructures and different histocytes of natural blood vessels, and then simulating mechanical parameters endured by in vivo blood vessels and blood flow situation. A purpose of repairing autologous blood vessels can be achieved. The material prepared according to the method is formed by culturing collagen and autologous histocytes of receptor in a blood vessel bioreactor, is approximate to autologous blood vessels, has high biocompatibility, has a growth potential, is unlikely to be infected, has stronger mechanical properties, is capable of bearing the resilience of interwall pressure and blood to vascular walls, has an excellent effect of resisting against thrombosis and platelet adhesiveness and is beneficial to vascular repair of vascular transplantation.