Application of circ_SLC7A5 molecular marker in blood in diagnosing esophageal squamous carcinoma and prognosis

Abstract

The invention discloses application of a circ_SLC7A5 molecular marker in blood in diagnosing esophageal squamous carcinoma and prognosis, and relates to discovery, detection and application of the circ_SLC7A5 molecular marker. A specific detection primer for real-time quantitative PRC is designed and synthesized. Circ_SLC7A5 in the blood can serve as a plasma marker for ESCC patients, aiming at the status quo that a target group of people have poor compliance on esophagus cancer endoscope screening, and most of esophageal squamous carcinoma patients with definite diagnosis in clinic are in themiddle and advanced stage, ideal molecular early-warning signals are found out in the esophagus squamous cell canceration process, endoscopy is targetedly carried out, the pathology is conformed, sothat the pain of the patients is alleviated, excessive medical treatment is avoided, and medical resources are saved.

Description

technical field [0001] The invention relates to the field of tumor molecular biology, in particular to the application of a circ_SLC7A5 molecular marker in blood in the diagnosis and prognosis of esophageal squamous cell carcinoma. Background technique [0002] Esophageal cancer is one of the most common malignant tumors that seriously threaten human health. There are two main pathological types: squamous cell carcinoma and adenocarcinoma. 90% of esophageal cancers are squamous cell carcinomas, and their distribution has obvious geographical differences. The incidence of ESCC in my country accounts for more than 70% of the world, and the prognosis is poor. The 5-year overall survival rate is only 15%-25%. In 2016, the Journal of Clinician Cancer reported that esophageal cancer has become one of the five most common tumors in China, ranking third among men and fifth among women. [0003] Circular RNAs (circRNAs), a new type of endogenous non-coding RNA, were identified as t...

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Problems solved by technology

[0005] In order to solve the above problems, the present invention discloses the application of circ_SLC7A5 molecular marker in blood in the diagnosis and prognosis of esophageal squamous cell carcinoma, aiming at the poor compliance of the target population with endoscopic screening for esophageal cancer and clinically diagnosed patients with esophageal squamous cell carcinoma Most of them are in the middle and advanced stages. It is proposed to find the ideal molecular early warning signal in the process of esophageal squamous cell carcinoma, and carry out targeted endoscopic examination and pathological diagnosis, so as to alleviate the suffering of patients, avoid excessive medical treatment, and save medical resources.

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