790 results about "Disulfide bonding" patented technology

The invention discloses a light-moisture dual-curing underwater epoxy coating with a self-repairing function as well as a preparation method and a construction method of the light-moisture dual-curing underwater epoxy coating. The epoxy coating comprises a component A and a component B, wherein the mass ratio of the component A to the component B is (1.5-3.5): 1; the component A is prepared from the following raw materials: bisphenol F type epoxy resin, dynamic disulfide bond modified polysulfide rubber, boron nitride nanosheet and silicon carbide nanowire hybrid filler, a photoinitiator and a silane coupling agent; the component B is prepared from the following raw materials: moisture-cured polyether amine, a boric acid ester bond cross-linking agent and hydrophobic modified graphene oxide. According to the invention, a light-moisture dual-curing mechanism is adopted, ultraviolet irradiation initiates rapid surface curing, and then environmental moisture permeates to complete deep curing. The material provided by the invention has the advantages of rapid curing, excellent self-repairing function, significantly improved underwater adhesion and good thermal conductivity, and provides a new solution for rapid repairing and long-acting protection of underwater structures.

The invention discloses a bidirectional reversible conversion method and system between a peptide molecule SMILES and a sequence expression. The core innovation lies in that a new sequence description syntax is defined to retain information of a polypeptide special bond and specific modification of amino acid; a main chain atom index and adjacency traversal topology identification algorithm is adopted, and end group and topology integrated detection and coding are carried out; a residue recognition algorithm for main chain cutting and template library matching is compatible with any standard or non-standard amino acid residues, an extensible end group library / monomer template library and an automatic increment mechanism, and automatic recognition and sequence annotation of S-S disulfide bonds; the invention relates to a high-fidelity assembly algorithm of HELM anchor points and topology aware cyclic peptide processing. The method solves the problems of incapability of supporting a complex polypeptide topological structure, poor reversibility, insufficient expansibility of a monomer library and the like in the prior art, can be widely applied to scenes of quantitative structure-activity relationship model construction, large-scale polypeptide data cleaning and the like, and has remarkable practicability and innovativeness.

The invention provides an ELISA (Enzyme Linked Immunosorbent Assay) kit for detecting an anti-MDA5 antibody and a preparation method of the ELISA kit. According to the kit, full-length human MDA5 protein (1025 amino acids) expressed by a cell-free protein expression system under the low-temperature condition of 22 DEG C is adopted as a coating antigen, and a disulfide bond enhancer E6820 is added into the system to promote correct folding of the protein. The kit comprises a microwell plate coated with a full-length MDA5 antigen, an enzyme-labeled anti-human IgG secondary antibody, a standard substance with the concentration range of 1-243 ng / mL, a chromogenic substrate and an optimized confining liquid system. The invention solves the problem of insufficient sensitivity caused by the use of fragment antigens in the prior art, and can be used for early diagnosis and illness monitoring of dermatomyositis-related interstitial lung diseases.

The invention belongs to the technical field of antibacterial peptides, and particularly relates to an antibacterial peptide Mh-GC21 as well as a precursor and application thereof. The amino acid sequence of the antibacterial peptide Mh-GC21 provided by the invention is as shown in SEQ ID NO.1, and two cysteines are oxidized to form a pair of intermolecular disulfide bonds; the C tail end of the antibacterial peptide Mh-GC21 is subjected to amidation modification. The antibacterial peptide Mh-GC21 provided by the invention is from microhyla microcarpa, has broad-spectrum antibacterial activity, has relatively good antibacterial and bactericidal effects on standard strains of acinetobacter baumannii, escherichia coli and staphylococcus aureus and clinically sourced drug-resistant strains, and can be used for targeted destruction of cell membranes of bacteria, removal of biological membranes and inhibition of formation of the biological membranes. Moreover, the antibacterial peptide Mh-GC21 has the advantages of good stability, no hemolytic activity and cytotoxicity, and difficulty in inducing strains to generate drug resistance.

The invention discloses a polylipoic acid-based composite sponge wound dressing and a preparation method and application thereof.The preparation method comprises the following steps that polylipoic acid amide with amino is obtained through disulfide bond ring opening polymerization, and the polylipoic acid amide and an aldehyde cross-linking agent are jointly dissolved in ethyl alcohol to form a solution A; carrying out high-speed shearing, dispersing and foaming on the water-soluble polymer, and freeze-drying to form porous sponge B; the porous sponge B is soaked in the solution A to be subjected to a cross-linking reaction, vacuum drying is conducted, and the polylipoic acid-based composite sponge wound dressing is obtained. The preparation method has the characteristics of simple preparation process, safety and no toxicity, the polylipoic acid with excellent oxidation resistance is introduced into the medical sponge material, the preparation method of the polylipoic acid medical porous structure material is obtained, the oxidation resistance and the wet viscosity of the medical sponge material are improved, and the medical sponge material has good application prospects. The application of the polylipoic acid-based porous material in the fields of hemostatic materials and wound dressings is realized.

The invention belongs to the technical field of bioinformatics, and discloses a protein disulfide bond mutation site prediction method and device, equipment and a storage medium, a plurality of candidate residue pairs are extracted by obtaining a prediction structure of a to-be-modified protein, and structural feature information of each candidate residue pair is extracted; comprising an inter-residue distance matrix of two residues, a sequence distance, a relative solvent accessible surface area of each residue, a depth index and a predicted local distance difference test value, inputting a prediction model to obtain a probability value of forming a disulfide bond by each candidate residue pair, determining the candidate residue pair with a probability greater than a specified probability as a disulfide bond mutation site, therefore, the bonding probability of the disulfide bond can be comprehensively predicted by using more comprehensive features, the high dependence of the model on individual traditional features is reduced, the high sensitivity of a traditional method on atomic coordinates and the uncertainty of a prediction result are overcome to a certain extent, and the method has higher robustness and is suitable for popularization and application. The prediction accuracy of the protein disulfide bond mutation site is improved.

The present application relates to a kind of high weather resistance and coating adhesion sunscreen coating and its preparation method, belong to sunscreen coating technical field;The present application uses the modifier with disulfide bond and polymerizable double bond to modify polyacrylate emulsion, significantly improve the flexibility of polyacrylate molecular chain after modification, reduce solidification shrinkage stress and internal stress, improve the coating adhesion of sunscreen coating of hard filler to matrix resin, it can also form stable chemical bonding between polyacrylate resin and titanium dioxide, provide stable stress transfer path, reduce the cracking and warping of coating, in addition, the modifier of the present application has good heat resistance aromatic ring structure, using the modifier of the present application can improve the heat resistance of sunscreen coating without introducing additional modifier.

The invention relates to the technical field of photovoltaic glass coatings, and discloses an anti-reflection liquid with a self-repairing function, a preparation method of the anti-reflection liquid and an organic-inorganic hybrid coating prepared from the anti-reflection liquid. The polyurethane-silicon dioxide composite resin with a disulfide bond structure is introduced, so that an automatic repairing function of the coating when the coating is damaged by slight scratches or cracks and the like is realized; by adopting an in-situ hybridization strategy, SiO2 particles are uniformly generated and stably dispersed in a polyurethane matrix to form a compact and synergistically enhanced composite network structure, so that excellent optical performance is maintained while functionality is achieved, and the power generation efficiency of a photovoltaic module is favorably improved; by adjusting the hydrophobicity of the surface of the coating, the super-hydrophobic effect is achieved; the preparation method is mild in process conditions.

The invention relates to the field of preparation of lubricating materials, in particular to a preparation method of composite phase change lubricating gel based on temperature-friction force synergistic response. The lubricating gel adopts a sandwich layered structure; the bottom layer is a porous ceramic layer formed by micro-arc oxidation, is filled with a disulfide bond dynamic network polymer and is anchored on a metal substrate; the middle layer comprises a microencapsulated phase change material which is dispersed in a polyurethane network containing dynamic disulfide bonds and is wetted with ionic liquid; the surface layer is an epoxy resin coating rich in boron nitride nanosheets, and a rapid heat conduction channel is constructed. Compared with the prior art, the lubricating state can be automatically adjusted in the friction process without external energy input, and the method has the advantages of being sensitive in multi-field coupling response, capable of achieving automatic antifriction protection, high in extreme working condition adaptability and the like.

The invention discloses a super-tough temperature-resistant self-repairing copolymer based on SBS acrylate dynamic synergistic reinforcement and a preparation method thereof, and belongs to the technical field of self-repairing materials in compositions of high-molecular compounds. The copolymer comprises SBS, an acrylate monomer, a dynamic bond functional monomer, an initiator, a cross-linking agent, a nano reinforcing agent and a temperature-resistant modifier, wherein the dynamic bond functional monomer comprises at least one of acryloyloxyethyl disulfide, acrylamide acryloyloxyethyl disulfide or anthracene methyl acrylate. The molecular structure of the dynamic bond functional monomer contains a carbon-carbon double bond and a disulfide bond, in the free radical polymerization reaction initiated by the initiator, the carbon-carbon double bond is opened and is subjected to a copolymerization reaction with an SBS chain segment or an acrylate chain segment, so that the disulfide bond enters the polymer chain segment, the dynamic disulfide bond can be reversibly broken and recombined at high temperature, and the dynamic bond functional monomer is obtained. The high-temperature viscoelasticity is maintained, the material is endowed with self-repairing capability, and the problem that the viscoelasticity of the material in the prior art is sharply reduced at high temperature (gt; 120 DEG C) is solved.

The invention belongs to the technical field of functional polymer composite caulking materials, and relates to a polyurethane caulking material based on shape memory assisted self-repairing and a preparation method thereof. The polyurethane caulking material is prepared from the following raw materials in parts by mass: a component A and a component B, the component A is prepared from 20 to 30 parts of isocyanate and 100 parts of polyhydric alcohol; and the component B comprises 1-13 parts of a sulfur-containing chain extender for providing dynamic disulfide bonds, 1-5.4 parts of a common chain extender, 0-30 parts of a plasticizer, 0.5-1.5 parts of a water removal agent and 20-40 parts of a solvent. During preparation, the component B and the component A are mixed at the temperature of 40-60 DEG C, defoamed at the temperature of 30-50 DEG C and then injected into a mold, and the polyurethane caulking material based on shape memory assisted self-repairing is obtained after curing. The problem that an existing polyurethane caulking material lacks self-repairing capacity after cracks are generated is solved.

The invention discloses an amyloid-like protein mediated long-acting metal organic framework antifouling agent as well as a preparation method and application thereof. Belongs to the field of marine antifouling material preparation. The anti-fouling agent is based on MOF with an anti-fouling function, and amyloid-like protein is self-assembled on the surface of the MOF to form a compact protective shell layer. According to the preparation method, metal ions and organic ligands react and are connected through coordinate bonds to form an MOF structure, and MOF particles are obtained through centrifugation, collection, precipitation, washing and drying; under the action of a water-soluble organic reducing substance, the protein completely opens a disulfide bond to form an unfolded protein chain, and the protein chain is self-assembled to obtain an amyloid-like protein solution; and placing the MOF particles in an amyloid-like protein solution, and carrying out simple one-step incubation to obtain the amyloid-like protein mediated long-acting metal organic framework antifouling agent. The antifouling agent is prepared by adopting a novel green, high-stability, rapid and efficient mild modification method, and has the advantages of stability, durability, universality and high efficiency.

The invention discloses an RSV pre-F tripolymer protein combination and application thereof in preparation of bivalent RSV vaccines, and relates to the technical field of human vaccines. The vaccine is prepared by mixing an RSV-A subtype pre-F tripolymer protein and an RSV-B subtype pre-F tripolymer protein in equal mass, and matching with an aluminum hydroxide adjuvant with the concentration of 0.35 mg / 0.5 mL. A p27 fragment and a C-terminal esterification region of each of the two F proteins are deleted, the two F proteins are connected with F2 / F1 through GSGSGS, inter-chain disulfide bonds are introduced to S146C / N460C and A149C / Y458C sites respectively, intra-chain disulfide bonds are introduced to S155C / S290C sites respectively, and stable pre-F trimers are spontaneously assembled after secretion expression of CHO cells; the vaccine does not need to be freeze-dried, still keeps high purity and neutralizing epitope integrity after being stored at 37 DEG C for 28 days, can obviously induce neutralizing antibody and T cell immunity, and can be used for preventing various RSV-A / B infections.

The invention relates to room-temperature self-repairing polyurethane with quadruple hydrogen bonds / disulfide bonds and a preparation method of the room-temperature self-repairing polyurethane, and the prepared polyurethane is a thermoplastic polymer and shows a dynamic cross-linked structure. The polyurethane is prepared by adopting a step-by-step polymerization method in the presence of two chain extenders containing different dynamic bonds, the prepared polyurethane has good mechanical properties, self-repairing of cracks can be realized in a room temperature environment, and the method is simple and easy to industrialize. The polyurethane has important application value in the industries of flexible electronics, medical instruments, long-acting protection and the like.

The application provides a reverse osmosis membrane and a preparation method and application thereof. The preparation method comprises the following steps: (1) polymeric reaction of a polyamine and a polyacyl chloride on a support membrane to form a polyamide layer on the support membrane; and (2) reaction of the polyamide layer prepared in step (1) and a benzene series A to obtain the reverse osmosis membrane; the benzene series A is a benzene series containing an amino group, an antibacterial group, a disulfide bond and a phenoxy group. The reverse osmosis membrane provided by the application has high flux and high desalination rate, and excellent oxidation resistance, antibacterial property and acid and alkali resistance.

The invention discloses a bio-based recoverable high-thermal-conductivity dynamic ordered network composite material and a preparation method thereof, and is characterized in that the material takes a bio-based multifunctional epoxy system and a carboxylic acid compound containing disulfide bonds as reaction monomers, and the reaction monomers are reacted under the conditions of high temperature and metal salt catalyzed epoxy-carboxylic acid esterification reaction to obtain the bio-based recoverable high-thermal-conductivity dynamic ordered network composite material. A dynamic ordered network structure simultaneously containing disulfide bonds and beta-hydroxyl ester bonds is constructed, and the dynamic ordered network can be used as a springboard for phonon transmission, serves as an efficient'thermal bridge ', and plays a role similar to an ordered'crystal domain', so that higher heat-conducting property is shown when heat-conducting filler is not introduced, high flexibility and intrinsic heat conduction are realized, and the service life of the material is prolonged. And the material is endowed with reprocessing and recycling characteristics. Due to the synergistic existence of carboxyl, hydroxyl generated by epoxy ring opening and metal coordination in the system, and in combination with electrostatic interaction, Van der Waals force and hydrophobic interaction, the material has the adhesion characteristic suitable for a thermal interface at the same time.

The application discloses a method for inhibiting the migration of toxic small molecules in plastics based on a protein-based phase transition composite coating, which is characterized by the following steps: inducing the rapid phase transition of proteins on the surface of plastics by a disulfide bond reducing agent to form a nanofilm, and adsorbing polysaccharides on the surface of the nanofilm to form a protein-based phase transition composite coating on the surface of the plastics, which can inhibit the migration of toxic small molecules in the plastics. The preparation method of the protein-based phase transition composite coating is simple, the cost is low, the inhibition effect on the migration of phthalate plasticizers and bisphenol A in plastics (such as PVC, PP, PE, PS and PET) is good, the adsorption of drugs on the surface of medical plastics can be prevented at the same time, the protein-based phase transition composite coating has good biocompatibility, is suitable for temperature-sensitive plastics, has universality, can be safely used on the surface of food and medical plastic products, and has a good popularization and application prospect on the surface of plastics.

The invention discloses iron oxide nanoparticles capable of responding to particle size change in a tumor microenvironment and a preparation method of the iron oxide nanoparticles, and belongs to the technical field of biomedical nano materials. The nano-particle comprises an iron oxide nano-crystal core with the particle size of 3-5nm and a tumor microenvironment response layer coating the surface of the iron oxide nano-crystal core. The response layer contains groups, such as disulfide bonds, enzyme digestion peptide fragments and the like, which can respond to acidic pH, high-concentration reduced glutathione or matrix metalloproteinase and other tumor characteristic stimuli to generate structural changes. In a tumor microenvironment, the hydration particle size of the nanoparticles can be directionally and controllably converted from 3-20 nm to 20-100 nm (or reversely). The preparation method mainly comprises two steps of preparing the core by a thermal decomposition method and modifying the surface response layer. The technical problems of insufficient tumor targeted enrichment capacity, limited imaging contrast and difficulty in balancing permeation and retention caused by fixed particle size of the existing iron oxide nanoparticles are solved, and the accuracy and efficiency of tumor diagnosis and treatment can be remarkably improved.

The invention relates to the field of polymer composite materials, and provides an ionized surface treatment aramid pulp enhanced peroxide fluorine rubber compound for improving wear resistance and fatigue resistance through dynamic covalent bonds and gradient interface design. According to the rubber compound, fluoroperoxide rubber is used as a matrix, and aramid pulp treated by ionic liquid containing dynamic disulfide bonds and a novel filler compounded by boron nitride nanosheets and carbon black are added; an aramid surface gradient layer is formed through layer-by-layer impregnation, a reversible covalent bond network is formed during vulcanization, and interface self-repairing is achieved; by combining low-temperature plasma-assisted banburying and segmented vulcanization processes, the wear resistance and fatigue resistance of the material are remarkably improved, and compared with a traditional material, the material is better in performance and has wide application potential.

The invention relates to a super-amphiphobic coating with a dual self-repairing function and a preparation method of the super-amphiphobic coating. According to the super-amphiphobic coating, crack self-repairing is achieved through dynamic disulfide bonds, and low-surface-energy substance self-repairing is achieved through microcapsules. The preparation method comprises the following steps: firstly, modifying hydroxyl-terminated polydimethylsiloxane by using an isocyanate prepolymer containing disulfide bonds, then modifying TiO2 nanoparticles by using 3-aminopropyltriethoxysilane and octadecyltrimethoxysilane, and preparing a microcapsule which takes polyamide as a shell and perfluorooctyltriethoxysilane as a core material, and finally, carrying out ball-milling mixing on the disulfide bond-containing polyurethane modified organic silicon resin, the modified TiO nanoparticles, microcapsules and 2-hydroxy-2-methyl propiophenone, and spraying the mixture on the surface of a base material to obtain the super-amphiphobic coating with the dual self-repairing function. According to the super-amphiphobic coating with the dual self-repairing function and the preparation technology thereof, the coating achieves high durability through dual self-repairing, and the hydrophobic and oleophobic performance is high.

The invention provides an alginate lyase mutant Amut8C as well as a coding gene and application thereof, belongs to the technical field of gene engineering and enzyme engineering, and can solve the problem that existing alginate lyase cannot meet the requirements of severe reaction conditions such as high temperature and acidity in industrial application. The amino acid sequence of the alginate lyase mutant Amut8C disclosed by the invention is as shown in SEQ ID NO. 1. According to the space structure of the alginate lyase Algt, disulfide bonds in molecules are analyzed, the alginate lyase is mutated, and the obtained alginate lyase mutant Amut8C has heat resistance, acid and alkali resistance and digestive enzyme tolerance, and compared with the alginate lyase Algt, the alginate lyase mutant Amut8C has the advantages that the content of the alginate lyase mutant Amut8C is increased, and the content of the alginate lyase mutant Amut8C is increased. The alginate oligosaccharide with the polymerization degree of 1-4 prepared from the alginate lyase mutant Amut8C under the same enzymolysis condition is higher in yield. The method can be applied to the fields of feeds, foods, detergents or biofuels.

The invention provides a composite silicon-carbon negative electrode material and a preparation method thereof, a negative electrode plate and a battery. The composite silicon-carbon negative electrode material comprises a silicon-carbon composite core, and a gradient pore carbon buffer layer and a dynamic self-healing binder layer which sequentially coat the surface of the silicon-carbon composite core, a branched carbon nanostructure grows in the pore wall of the gradient pore carbon buffer layer, the dynamic self-healing binder layer partially permeates into the pores of the gradient pore carbon buffer layer, the dynamic self-healing binder layer contains dynamic disulfide bonds, and the dynamic self-healing binder layer comprises a composite binder and a conductive high-molecular polymer. According to the invention, the gradient pore buffer layer is arranged on the surface of the silicon-carbon particles, and meanwhile, the self-healing binder containing dynamic disulfide bonds is used for permeation filling, so that three-dimensional cooperative regulation and control of graded dissipation of expansion stress, self-repairing of microcracks and ion / electron dual-path conduction are realized; the three core problems of electrode pulverization caused by volume expansion, interface impedance sharp increase and long circulation capacity attenuation are thoroughly solved.

The invention discloses a double dynamic bond self-repairing polyurethane elastomer as well as a preparation method and application thereof, and belongs to the technical field of high polymer materials. The elastomer is prepared from the following raw materials in percentage by mass: 74 to 76 percent of polyether polyol, 15.5 to 18 percent of diisocyanate, 1.67 to 7 percent of dihydrazide compound and 2.1 to 6.7 percent of disulfide. The preparation method comprises the following steps: firstly, reacting polyether polyol with diisocyanate to obtain a prepolymer, then sequentially carrying out step-by-step chain extension reaction on the prepolymer, the bishydrazide compound and the disulfide compound, and finally, curing and forming. According to the invention, a synergistic structure of a hydrogen bond hard segment and a disulfide bond soft segment is constructed step by step, so that the material has high mechanical properties and efficient self-repairing capability. The elastomer is suitable for the fields of industrial pipeline sealing pieces, flexible packaging films, sports equipment accessories and the like, and solves the problem that the strength and repairing performance of an existing self-repairing polyurethane material are difficult to balance.

The invention discloses a polyurea composite coating based on MXene at carbon dots. The composite coating is prepared by heating and curing a polyurea composite elastomer based on MXene at carbon dots and an organic solvent, the polyurea composite elastomer based on the MXene (at) carbon dots is prepared by mixing a polyurea elastomer and MXene (at) carbon dot powder; the polyurea elastomer is prepared from the following raw materials: isophorone diisocyanate, poly (propylene glycol) bis (2-aminopropyl ether), isophthaloyl hydrazine and 4, 4 '-diaminodiphenyl disulfide through a two-step condensation polymerization reaction. Based on the synergistic effect of dynamic hydrogen bonds and flexible disulfide bonds of a self-repairing polyurea elastomer structure in the composite coating, the self-repairing characteristic of the composite coating is remarkably enhanced, meanwhile, a brick mud structure is formed through uniform embedding of MXene at carbon dots, and the mechanical strength, corrosion resistance, heat stability and rapid self-repairing capacity of the composite coating are greatly improved.

The invention discloses high-toughness self-repairing polyurethane based on a ureido / disulfide bond dual dynamic network and a preparation method of the high-toughness self-repairing polyurethane, and belongs to the technical field of self-repairing high polymer materials. The structural formula of the thermal stimulation repairing polyurethane is shown in the specification. The polyurethane is formed by mixing and polycondensing polyether amine, diaminodiphenyl disulfide and dicyclohexylmethane diisocyanate. According to the invention, polyether amine is used as a raw material, green synthesis without a catalyst is realized, ureido generated by the reaction forms a hydrogen bond network with extremely strong dynamic property and cooperates with a disulfide bond, a repair process is completed at 50 DEG C, the toughness can reach 40.55 MJ / m < 3 >, the fast recovery capability is realized, the material can be stretched to be 20 times of the original length, and the service life of the material is prolonged. Good network dynamic property is achieved at the room temperature, and high self-repairing efficiency is achieved at the room temperature.

The invention discloses a disulfide bond-containing self-repairing silicon-based polyurea coating as well as a preparation method and application thereof, and belongs to the technical field of self-repairing coating materials. The preparation method of the disulfide bond-containing self-repairing silicon-based polyurea coating comprises the following steps: reacting aminopropyl terminated polydimethylsiloxane with diisocyanate to generate a silicon-based polyurea prepolymer; and then adding a mixed solution of amino-terminated disulfide and polyamine into the silicon-based polyurea prepolymer to carry out chain extension reaction, and then carrying out vacuum defoaming and drying to obtain the disulfide bond-containing self-repairing silicon-based polyurea coating. The synergistic effect of the disulfide bond and the hydrogen bond is realized through the chain extender with the disulfide bond, so that the self-repairing requirement is met.

The invention relates to a polyurethane-based composite solid polymer electrolyte film and a preparation method and application thereof, and belongs to the field of organic polymer solid electrolyte preparation. Polyethylene glycol-polypropylene glycol triblock copolymer and hydroxyl-terminated polybutadiene are used as soft segments, isophorone diisocyanate is used as a hard segment, and under the action of a catalyst, the polyurethane-based composite solid polymer electrolyte film is prepared. A chain extender containing disulfide bonds is utilized, and a polyurethane elastomer is prepared through gradual addition polymerization reaction; a polyurethane elastomer and a mixed solution of a lithium salt and a polyvinylidene fluoride-hexafluoropropylene copolymer are uniformly mixed, the polyurethane elastomer accounts for 10%-30% of the mass of the polyvinylidene fluoride-hexafluoropropylene copolymer, a precursor solution is obtained, the precursor solution is prepared into a film, and the polyurethane-based composite solid polymer electrolyte film is obtained. The polymer solid electrolyte membrane with excellent mechanical property and excellent lithium ion conductivity is constructed, and the development requirement of a high-performance lithium metal battery is met.

A secondary battery and a manufacturing method therefor, a gel electrolyte, and an electrical apparatus. The secondary battery comprises an outer package, and an electrode assembly and a gel electrolyte accommodated in the outer package; the gel electrolyte comprises a polymer, a solvent and an electrolyte salt; the polymer comprises an acrylate group and a disulfide bond.

The application discloses a mucous membrane adhesion auxiliary material and a lipid material with mucous membrane adhesion prepared by using the auxiliary material, the nanoparticle has mucous membrane adhesion and can be adhered to the surface of a mucous membrane and is suitable for mucous membrane administration. The lipid nanoparticle promotes the entry of the lipid nanoparticle into cells by forming a disulfide bond with the sulfydryl on the surface of mucous membrane cells, and the entry of the lipid nanoparticle into cells is a non-endosome-lysosome pathway, so that the encapsulated nucleic acid macromolecule can be avoided from being degraded by enzymes in cells, thereby directly delivering the macromolecular nucleic acid in the cytoplasm to play a role.

The application discloses a photosensitizer conjugate for targeted treatment of tongue squamous cell carcinoma and a preparation method and application thereof, and belongs to the technical field of biological medicines. A novel PROTAC-PDT conjugate Gef-PRO-SS-TPE is synthesized, and the compound connects a PROTAC molecule Gef-PRO targeting EGFR and an AIE photosensitizer TPE derivative through a breakable disulfide bond. On one hand, Gef-PRO can specifically degrade EGFR and block tumor cell proliferation signals; on the other hand, the TPE derivative can generate ROS under light conditions and induce cell apoptosis. More importantly, the disulfide bond can be broken in response to high concentrations of glutathione (GSH) in tumor cells, realizing controllable release of Gef-PRO and TPE molecules, so as to exert a synergistic anti-tumor effect.