359 results about "Bacteriocyte" patented technology

The invention relates to an antibacterial PP material and a preparation method thereof, and belongs to the technical field of high polymer materials. The antibacterial PP material is prepared from the following components in parts by weight: 60 to 80 parts of PP resin, 2 to 4 parts of a surfactant, 0.5 to 1.5 parts of a modified antibacterial agent, 0.5 to 1.5 parts of a flame retardant and 0.2 to 0.8 part of an antioxidant, titanium ions in the modified antibacterial agent destroy bacterial cell walls, quaternized intermediate products react with proteins of cell membranes to accelerate bacterial death, and in addition, phenolic hydroxyl groups absorb ultraviolet rays with different wavelengths to inhibit the light aging process; a compact and continuous carbon layer is formed during combustion of the flame retardant and cooperates with phosphorus-oxygen double bonds and melamine, the flame retardant efficiency is improved, aluminum hydroxide coats the surface, hydroxyl is subjected to heat absorption decomposition during combustion, the surface temperature of combustible materials is stabilized, meanwhile, an inert aluminum oxide layer is formed, and the flammability is reduced. The antibacterial PP material prepared by the invention not only has good antibacterial and anti-aging effects, but also has excellent flame retardant property.

The invention discloses a leak-free core-shell hydrogel microsphere delivery system for non-contact flora transplantation as well as a construction method and application of the leak-free core-shell hydrogel microsphere delivery system. According to the invention, bacteria are encapsulated in a core of a core-shell microsphere through a two-step photo-initiation emulsion polymerization method of methacrylic acid gelatin, and a non-contact microbiota transplantation system (NMTS) is constructed. The NMTS can be used for biological encapsulation of various strains, shows encapsulation efficiency close to 100%, and has little influence on bacterial activity at the same time. NMTS demonstrates: a shielding effect that protects sealed bacteria from low pH values in the gastrointestinal tract and bile acid disruption; sufficient mechanical strength ensures that bacterial leakage is prevented and the infection risk is eliminated in the whole gastrointestinal tract delivery process; and internal and external substance exchange is realized, and the intestinal microorganism structure is remodeled. The invention provides a unique bacterial cell microencapsulation method which is a non-contact, safe and effective micropopulation transplantation method.

The invention discloses a deep mutation scanning method based on protein-protein interaction in bacterial cells and a binding affinity prediction method. In the invention, split dCas9 proteins (SEQ ID NO.1 and SEQ ID NO.2) are respectively subjected to fusion expression with a receptor and a ligand with binding affinity to be detected, and are combined with a toxic sgRNA guide sequence (SEQ ID NO.3), and when PPI occurs, a toxic dCas9: sgRNA complex is formed to inhibit bacterial growth, so that a PPI affinity size signal is converted into a bacterial cell generation speed signal, and the signal can be quantified into a copy number value through next-generation sequencing. The invention further designs a deep learning binding affinity prediction model, high-affinity sequences can be screened from theoretical mutation space, the workload and cost of experimental verification are remarkably reduced, and a reliable basis is provided for subsequent protein function optimization and design.

The invention relates to a nano preparation for delivering antibiotics based on plant extracts and application of the nano preparation, and belongs to the technical field of nano preparations. In order to solve the problems of low bioavailability and low action efficiency of oral administration or intravenous injection of antibiotics in the lung disease treatment process, the invention provides a nano preparation for delivering antibiotics based on plant extracts. The mass volume ratio of the antibiotics to the plant extract in the nano preparation is (1-10) mg: (20-100) mu L. The nano preparation disclosed by the invention can obviously inhibit the migration of fibroblasts, has an obvious bacteriostatic effect and can reduce the density of microorganisms in lungs; positive charges carried by the material are combined with negative charges on the surface of a bacterial cell membrane, transmembrane substance transfer on the bacterial cell membrane is affected, bacterial metabolism and reproduction are affected, adjustment of pulmonary symbiotic bacteria is better achieved, and the pulmonary fibrosis progress can be relieved. The nano preparation has the advantages of small toxic and side effects, good patient compliance, high encapsulation efficiency and the like.

The disclosure relates to the field of specialty chemicals and methods for their synthesis. In embodiments, the disclosure provides viable bacterial cells which comprise heterologous dual 3-hydroxy-acyl-ACP dehydratase / isomerases, etc. The disclosure further provides monounsaturated fatty acid derivative molecules produced by the viable bacterial cells which are non-native to the bacterial cells. The disclosure further provides methods for the preparation and production of non-native monounsaturated fatty acid derivative molecules such as e.g., an ω3-monounsaturated fatty acid derivative, an ω5-monounsaturated fatty acid derivative, an ω9-monounsaturated fatty acid derivative, an ω11-monounsaturated fatty acid fatty acid derivative, etc.

The invention relates to the technical field of polypeptides, and discloses a soybean polypeptide with an antibacterial function and a preparation method thereof.The soybean polypeptide with the antibacterial function is obtained by adding soybean polypeptide, quaternized cholic acid and modified chitosan into N, N-dimethylformamide and stirring for reaction. A chitosan group, a quaternary ammonium salt group, an imidazole group and a cholic acid group contained in the soybean polypeptide with the antibacterial function jointly form an antibacterial system, and a good antibacterial effect is achieved; wherein the chitosan group can destroy bacterial cell walls to death bacteria, so that the antibacterial effect is achieved, and the cholic acid group also has a relatively good antibacterial effect; the imidazole group rapidly kills bacteria by destroying bacterial cell membranes, affecting bacterial metabolism and inhibiting formation of biological membranes, a good antibacterial effect is achieved, quaternary ammonium salt is adsorbed to the negatively charged bacterial cell membranes through the cationic characteristics of quaternary ammonium salt, the cell membranes are broken, and therefore the bacteria are rapidly killed.

The invention discloses antibacterial poly (beta-amino ester) and a preparation method and application thereof, poly (beta-amino ester) macromolecules simultaneously have amino positive charges and fluorine-containing hydrophobic components, existence of the positive charges enables the poly (beta-amino ester) macromolecules to be more easily combined with negatively charged bacterial cell membranes and to be enriched, and the hydrophobic components can enable the poly (beta-amino ester) macromolecules to be inserted into cell membrane phospholipid bilayers, so that the antibacterial effect is improved. Therefore, bacteria are effectively killed, and drug resistance is not easily caused. The polymer has high antibacterial property and low hemolytic toxicity, can be self-assembled into nano particles, and can be combined with antibiotics in an antibiotic loading manner to improve the treatment effect. The compound can be synthesized through simple steps, the reaction condition is simple, the preparation cost, the raw material cost and the application cost are very low, and the compound has a very good prospect when being applied to medicines for treating or preventing diseases caused by bacteria.

The invention discloses a preparation method of photo-thermal-MMP dual-response matrix hydrogel and application of the photo-thermal-MMP dual-response matrix hydrogel in diabetic wound repair, and belongs to the technical field of biological medicine. According to the present invention, the Cur (at) ZIF-8 (at) MMPDA / dAMG composite hydrogel is composed of an amnion source photo-crosslinked matrix hydrogel, curcumin-loaded ZIF-8 nanoparticles and MMP2 peptide modified polydopamine, and the Cur (at) ZIF-8 (at) MMPDA / dAMG composite hydrogel is obtained; the ZIF-8 nanoparticles decline in an acid environment to release zinc ions, destroy bacterial cell membranes, enhance the permeability of a biological membrane and cooperatively kill drug-resistant bacteria in combination with a photothermal effect, Cur is loaded through ZIF-8 to form Cur-coated ZIF-8, then a Cur-coated ZIF-8-coated MMPDA / dAMG double-drug-loading system is constructed through an MMPDA medium, and a photothermal antibacterial, anti-inflammatory and regeneration-promoting multi-mode therapy is formed for a wound surface in the acid environment. Therefore, wound healing is accelerated.

The invention provides engineering lyase Art-15 with broad-spectrum antibacterial activity, antibacterial peptide NZ2114 and bacteriophage lyase PlySs2 are subjected to functional fusion through an optimally designed flexible linker, and an efficient bactericidal effect on Staphylococcus aureus (Staphylococcus aureus) and Streptococcus spp.) is achieved. The engineering lyase Art-15 has the advantages that the engineering lyase Art-15 has broad-spectrum antibacterial activity, the antibacterial peptide NZ2114 and the bacteriophage lyase PlySs2 are subjected to functional fusion through the optimally designed flexible linker, and the engineering lyase Art-15 has broad-spectrum antibacterial activity; the lyase Art-15 overcomes the defects of narrow host spectrum and insufficient splitting activity of the lyase through a synergistic destruction mechanism of targeting bacterial cell wall peptidoglycan. Experiments show that the minimal inhibitory concentration (MIC) of the lyase Art-15 on staphylococcus aureus in vitro is lower than 2 mu g / mL, the minimal inhibitory concentration of the lyase Art-15 on streptococcus agalactiae is lower than 1 mu g / mL, the minimal inhibitory concentration of the lyase Art-15 on streptococcus dysgalactiae is lower than 2 mu g / mL, and the sterilization rate of the lyase Art-15 can reach 97% or above within 30 minutes by 2 times of MIC. The lyase Art-15 disclosed by the invention has important application value in the fields of drug-resistant bacterium infection treatment, medical instrument disinfection and livestock breeding.

The invention discloses a composite antibacterial preparation containing antibacterial peptide and traditional Chinese medicines as well as a preparation method and application of the composite antibacterial preparation, and belongs to the technical field of biological medicines. The antibacterial peptide provided by the invention is a transmembrane protein derived from bacteriophage, and the core function of the antibacterial peptide is that bacterial cell lysis is promoted by destroying a connection structure of a peptidoglycan layer and lipoprotein of a bacterial cell wall, so that an antibacterial effect is achieved. The amino acid sequence of the antibacterial peptide is shown as SEQ ID NO: 3, the antibacterial peptide is combined with traditional Chinese medicines to form a composite antibacterial preparation, and experiments prove that the composite antibacterial preparation has a relatively good antibacterial effect on gram-positive bacteria and gram-negative bacteria and can be applied to the medical field, such as surgical instrument disinfection and drug-resistant bacterial infection treatment; the field of daily chemicals, such as antibacterial hand sanitizers and wound dressings; in the field of agriculture, for example, animal feed additives for preventing and treating intestinal infection have a good market application prospect.

The present disclosure provides engineered bacterial cells having one or more genetic modifications that result in increased production of expression products, such as increased production of plasmids with reduced occurrence of plasmid concatemers or multimers. Also disclosed herein are expression systems for product manufacturing in media having reduced antibiotic concentration, as well as methods of making cells for use in the expression systems. The cells and expression systems increase the growth rate and production yields of biomolecules produced within the host bacterial host cells without the use of antibiotics, and can produce the product with little to no endotoxins present.

The present disclosure provides engineered bacterial cells having one or more genetic modifications that result in increased production of expression products, such as increased production of plasmids with reduced occurrence of plasmid concatemers or multimers. Also disclosed herein are expression systems for product manufacturing in media having reduced antibiotic concentration, as well as methods of making cells for use in the expression systems. The cells and expression systems increase the growth rate and production yields of biomolecules produced within the host bacterial host cells without the use of antibiotics, and can produce the product with little to no endotoxins present.

The invention discloses a biodegradable light-package high-barrier packaging film and a preparation process, and relates to the technical field of packaging films, the biodegradable light-package high-barrier packaging film comprises the following components by weight: 8-15 parts of modified montmorillonite, 30-50 parts of modified nano cellulose, 5-10 parts of polyvinyl alcohol, 1.5-3 parts of a plasticizer, 0.25-0.6 part of curcumin, and 40-60 parts of deionized water. According to the biodegradable light-package high-barrier packaging film and the preparation process, montmorillonite is modified, so that the montmorillonite can interact with anions on a bacterial cell membrane, the integrity of the cell membrane is destroyed, and bacterial contents are leaked, thereby inhibiting growth and reproduction of bacteria and improving the antibacterial property of the packaging film; montmorillonite is a natural mineral material, is environment-friendly, and can change the crystal structure of polyvinyl alcohol, so that the degrading enzyme is easier to contact with a polymer molecular chain, and the degradation speed is accelerated.

The invention relates to the technical field of protective films, and discloses a mobile phone protective film and a preparation method thereof. Modified graphene oxide is used as a filler, a modified waterborne polyurethane emulsion is used as a film forming substance, a flatting agent and a defoaming agent are used as auxiliary materials, a waterborne polyurethane coating is prepared, the surface of a PET base material is coated with the waterborne polyurethane coating, then drying is conducted, and the mobile phone protection film is obtained. A quaternary ammonium salt group and negative charges on a bacterial cell membrane generate electrostatic attraction, so that the original structure and function of the cell membrane are destroyed, and a bactericidal effect is achieved; silanol groups generated by hydrolysis of silane groups can react with hydroxyl groups and carboxyl groups on the surface of a PET base material, so that the interface bonding force between the coating and the base material is improved; nitrogen atoms in pyrrolidone groups form hydrogen bonds with hydroxyl groups and carboxyl groups on the surface of a base material, so that the bonding strength of the coating and the base material is further improved; the adamantyl group is grafted into the graphene oxide, so that the supporting effect of the graphene oxide on the waterborne polyurethane is enhanced, and the mechanical property of the mobile phone protective film is improved.

The present invention provides an improved Bacillus cell having reduced expression of a metalloprotease gene. Inactivation of the metalloprotease gene reduces proteolytic degradation of a protein of interest produced by said Bacillus cell and thus, improves the yield of the protein of interest in such production method. The present invention is also directed to a method of inactivating the metalloprotease and the application of this method of inactivation when producing a protein of interest.

The invention relates to the technical field of antibacterial agents, in particular to a compound antibacterial agent of a plant polyphenol complex and a preparation method of the compound antibacterial agent. The compound antibacterial agent is prepared from the following raw materials in parts by weight: 20-30 parts of moutan bark extract, 20-30 parts of folium mori, 20-30 parts of a carrier, 10-20 parts of jerusalem artichoke extract, 10-20 parts of coptis chinensis extract, 2-4 parts of a tackifier and 1-3 parts of a microbial agent. According to the invention, paeonol in moutan bark, chlorogenic acid in mulberry leaves, berberine in coptis chinensis and inulin polyphenol in jerusalem artichoke can be combined with lipid of bacterial cell membranes, so that membrane permeability is increased, microbial metabolic enzymes are interfered, energy metabolism and biosynthesis are blocked, free radicals are removed, and antibacterial effects of other components are enhanced; folium mori is hydrolyzed through beta-glucosidase to release free polyphenol, gluconolactone adjusts the acid environment to promote polyphenol dissolution, and the antibacterial effect of the composite antibacterial agent is effectively improved.

The invention relates to the technical field of home textile fabric preparation, in particular to an antibacterial and anti-mite home textile fabric and a preparation process thereof. The preparation process comprises the following steps: preparing a zinc zeolite carboxylic acid composite material; purified nano platinum is prepared; and preparing the antibacterial and anti-mite home textile fabric. Zinc and methylimidazole are compounded to form a zinc zeolite structure similar to zeolite, 1, 3, 5-benzenetricarboxylic acid is added into the zinc zeolite structure to form a composite metal organic framework, and the composite metal organic framework can enlarge the contact area with bacteria, so that 1, 3, 5-benzenetricarboxylic acid has an opportunity to contact with key metabolic enzymes in bacterial cells, and the bacterial activity is improved. Meanwhile, the zinc ions can be slowly released along with time after the composite metal organic framework is combined with the zinc ions, and the slowly released zinc ions have the antibacterial characteristic and can interfere the metabolic process of bacteria and inhibit the growth of the bacteria, so that the long-acting antibacterial effect is achieved.

The invention belongs to the technical field of photosensitizers, and particularly relates to design, synthesis and sterilization application of an aggregation-induced emission probe based on a biological orthogonal reaction metabolism anchoring viable bacterium strategy. The aggregation-induced emission compound (aggregation-induced emission probe) is of a typical D-pi-A structure, takes a triphenylamine structural unit as an electron donor spacer group in a molecular system to prevent pi-pi accumulation, and takes a thiophene ring and a carbon-carbon double bond as electron donors and a pi bridge and a nitro unit as electron acceptors to synthesize the aggregation-induced emission probe. And finally, an important synthetic raw material D-type amino acid (D-Ala) of a bacterial cell wall is also connected. The prepared aggregation-induced emission compound is long in fluorescence lifetime and high in fluorescence intensity, a large amount of active oxygen can be generated after illumination to effectively kill viable bacteria, the active oxygen can be absorbed and utilized by bacteria through metabolism, and differential detection of the viable bacteria and dead bacteria is achieved.

The invention discloses an antibacterial plastic and a production process thereof.The antibacterial plastic is prepared from, by weight, 100-120 parts of linear low-density polyethylene and 10-15 parts of antibacterial filler, antibacterial components in the antibacterial plastic are of an organic-inorganic composite structure, the problem of precipitation cannot occur in the long-time use process, and the antibacterial plastic is high in antibacterial performance and good in antibacterial performance. Meanwhile, the antibacterial filler contains a quaternary ammonium salt and quaternary phosphonium salt composite structure, due to the composite structure, the antibacterial filler has positive charges and can be adsorbed on the surfaces of bacterial cells with negative charges through electrostatic adsorption, and a guanidine structure can further adsorb bacteria, so that the normal physiological functions of the bacteria are interfered, the permeability of cell membranes is changed, and the antibacterial effect is improved. And the zinc organic framework can release zinc cations, so that the metal cations are adsorbed on the cell membranes, and the leakage of nutrient substances in bacteria is accelerated.

The invention relates to the technical field of cationic etherifying agents, and discloses a quaternary ammonium salt type cationic etherifying agent and a preparation method thereof. The invention provides a quaternary ammonium salt type cationic etherifying agent by adding 3-chloro-2-hydroxypropyltrimethylammonium chloride and sulfaguanidine modified quaternized chitosan into a reactor, stirring, and obtaining the quaternary ammonium salt type cationic etherifying agent. The quaternary ammonium salt, guanidine group, and chitosan group contained in the sulfaguanidine modified quaternized chitosan all have good antibacterial effects; wherein the quaternary ammonium salt is adsorbed onto the bacterial cell surface, and the hydrophobic group is inserted into the lipid layer, thereby changing the permeability of the cell membrane, destroying the membrane structure, causing the leakage of intracellular substances, and causing bacterial death; the guanidine group can interfere with the normal metabolic process of the bacteria by combining with proteins and nucleic acids in the bacterial cells, further inhibiting the growth and reproduction of the bacteria, thereby playing a natural antibacterial effect; and the chitosan group itself has a good antibacterial effect.

The invention provides an antibacterial peptide CN-3 and application thereof, and relates to the technical field of peptide inhibitors. The amino acid sequence of the antibacterial peptide CN-3 is GPGGAWAAKVIS, and is as shown in SEQ ID NO. 1. The minimum inhibitory concentration (MIC) of the antibacterial peptide CN-3 to staphylococcus aureus and escherichia coli is 5.0 mg / mL. According to the antibacterial peptide CN-3 and the application thereof, the CN-3 has staphylococcus aureus and escherichia coli bacteriostatic activity, and plays a role by destroying bacterial cell membranes; cN-3 is not easy to generate drug resistance, low in cytotoxicity and high in cell selectivity, and can be used for preparing an antibacterial composition for treating staphylococcus aureus and escherichia coli infection.

The invention discloses bacteriostatic and antibacterial lithium disilicate glass ceramic and a preparation method thereof. The bacteriostatic and antibacterial lithium disilicate glass ceramic comprises the following components in percentage by weight: 60-70% of lithium disilicate whiskers, 5-12% of a nucleating agent, 1-5% of aluminum oxide, 1-4% of calcium oxide, 5-10% of an antibacterial agent and 12-18% of fluorapatite, wherein the nucleating agent is formed by compounding phosphorus pentoxide and zirconium oxide, and the antibacterial agent is formed by compounding silver oxide and zinc oxide; the invention relates to the technical field of lithium disilicate glass ceramics. In the glass ceramic, silver ions can be combined with groups such as sulfydryl and amino in bacterial cells to interfere the metabolic process of bacteria and inactivate enzymes of the bacteria so as to inhibit growth and reproduction of the bacteria, and zinc ions can influence permeability of bacterial cell membranes and destroy physiological functions of the bacteria and cooperate with the silver ions to enhance the antibacterial effect of the glass ceramic.

Provided herein are improved methods for producing engineered bacterial cells of circular DNA vectors, circular DNA vectors produced by such methods, and pharmaceutical compositions containing such circular DNA vectors. The methods provided herein are suitable for large scale production of high purity compositions of circular DNA vectors.

The invention discloses an intelligent quintuplet cooperative plasma self-purification robot long-term storage system and a self-adaptive disinfection control method. According to the system, cold plasma, ozone, chlorine dioxide, self-generated nitric oxide and a charge self-purification jump effect are fused, and a dynamic self-purification system with an electric field-gas field-chemical field-intelligent field-thermal field five-dimensional synergistic energy field is constructed. The robot adopts a three-section structural layout and a multi-mode self-adaptive propulsion mechanism, environmental parameters are sensed through AI, discharge power and oxidant release are intelligently regulated and controlled, and precise sterilization, toxicity reduction and mildew prevention in a multi-medium environment are achieved. The system can generate various high-energy active species containing. OH, O, NO, ClO, ONOO and the like, chain splitting decomposition and oxidation mineralization are carried out on mold spores, bacterial cells, aflatoxin and the like, the sterilization rate reaches 99.995%, and the toxin degradation rate exceeds 98%. The system has the characteristics of no residue, low energy consumption, long-acting self-maintenance and the like, is suitable for multiple scenes of grain storage, traditional Chinese medicinal materials, cold chains, farmland, public health and the like, and realizes an intelligent, continuous and chemical-additive-free green storage and dynamic purification system.

The present application belongs to the technical field of medicine. Disclosed are a tumor vaccine, and a preparation method therefor and the use thereof. The raw materials of the tumor vaccine comprise a bacterial cell membrane and a liposome complex, wherein the raw materials of the liposome complex comprise a liposome and an aromatic lipid compound. The tumor vaccine provided includes the bacterial cell membrane and the liposome compound, wherein the liposome compound can fuse cells, the bacterial cell membrane can activate immunity, and the two used in combination can generate an excellent synergistic effect. Therefore, the immune escape state of the tumor cells is changed, DC cells infiltrating the tumor tissue can recognize and phagocytize tumor cells, and tumor antigens are presented, so that an in situ tumor vaccine is formed to achieve the anti-tumor effect. Moreover, the tumor vaccine provided has conventional raw materials, a simple preparation method, and good uniformity, which are beneficial to practical production and application.

The invention relates to the field of biological environmental protection, in particular to a heterotrophic nitrification immobilized engineering bacterium for efficient denitrification and a preparation method and application thereof.According to the heterotrophic nitrification immobilized engineering bacterium for efficient denitrification and the preparation method and application of the heterotrophic nitrification immobilized engineering bacterium, polyethylene glycol-glucan two-aqueous-phase concentration and trehalose protection liquid are adopted for synergistic effect, the bottleneck of cell damage caused by a traditional flocculation method can be avoided, trehalose molecules can wrap bacterial cells, and the bacterial cells can be effectively degraded; the immobilized particles can resist osmotic pressure impact and pollutant invasion, the survival rate of thalli is higher than 95%, so that the immobilized particles always keep ultrahigh denitrifying enzyme activity in various sewage environments, honeycomb-shaped pores are formed in an ethyl cellulose matrix, a microenvironment with a high specific surface area is provided for thalli attachment, and the built-in nano zeolite continuously and slowly releases Cu < 2 + > and Zn < 2 + > trace elements, so that the immobilized particles can be recycled. A thallus metabolism enzyme system is synergistically activated, and the denitrification pathway function is enhanced; the chitosan-polydopamine outer coating layer strongly captures the nitrogen-containing pollutants, so that the removal efficiency of the nitrogen-containing pollutants is improved; through triple protection, the density of unit granular bacteria is up to 109 cells / cm, the service life is prolonged, and the denitrification performance is improved by more than 40%.

The invention relates to the technical field of non-woven fabric preparation, in particular to biochemical modified antibacterial non-woven fabric and a preparation method thereof.After nano-zinc oxide and nano-titanium dioxide are modified through a silane coupling agent KH-570, the dispersity of nano-particles can be improved, and the antibacterial property of the non-woven fabric is improved; under illumination or contact conditions, active oxygen is released to destroy bacterial cell membranes and inhibit metabolism of the bacterial cell membranes, so that the antibacterial modified polypropylene master batch has stable antibacterial property; loading is stabilized through a polydopamine coating, so that the antibacterial performance of the lysozyme is stabilized, the lysozyme can specifically hydrolyze a peptidoglycan layer of a bacterial cell wall to cause bacterial lysis, thiourea dioxide serving as a reducing agent can maintain the activity of the lysozyme, oxidative inactivation is avoided, meanwhile, the activity of bacterial metabolic enzymes is inhibited, and the antibacterial activity of the lysozyme is improved. Through the inorganic / biological double-effect synergistic effect, gram-positive bacteria, gram-negative bacteria and fungi can be covered, so that the antibacterial performance of the non-woven fabric is improved to a certain extent.

The invention discloses a photoresponse-essential oil synergistic antibacterial polymer and an application thereof in resisting multiple drug-resistant bacteria. Citronellol (CT) is subjected to an esterification reaction to prepare a CMA monomer, the CMA monomer and a glycidyl methacrylate (GMA) monomer are copolymerized to prepare a polymer PG9C2, and then TBO is introduced to obtain the antibacterial polymer PG9C2T1. The improvement of the antibacterial activity of the TBO is derived from the improvement of the fat solubility of the TBO, the enhancement of the interaction between the TBO and bacterial cells, the improvement of the accumulation of the TBO in the cells, the penetration of the TBO through cell membranes and the play of roles in the cells, the improvement of the utilization efficiency of ROS, and the sterilization by improving the water solubility of the essential oil through the mechanism of destroying bacterial membranes. According to the invention, high-efficiency and low-toxicity drug-resistant bacteria based on natural products are synthesized, the limitation of a single antibacterial mode is broken through, and technical support is provided for developing a novel low-drug-resistance antibacterial therapy.

The invention relates to the field of chemical synthesis and biomedical materials, and discloses a multifunctional nano-drug and a preparation method and antibacterial application thereof, and the multifunctional nano-drug is mainly composed of a copper sulfide nano-carrier, a bacterial targeting photosensitizer and glucose oxidase (GOx). Wherein the copper sulfide nano-carrier (CuS NPs) has a hollow mesoporous structure and can effectively load drug molecules. The bacterium targeting photosensitizer, namely, D-cysteine functional modified pentafluorophenyl mycogreen (FBC-Cys), can be used for targeting bacteria by utilizing the characteristic that free D-type amino acid is integrated to the end of peptidoglycan on the surface of a cell wall in the cell wall synthesis process of the bacteria. Glucose oxidase (GOx) can efficiently consume glucose in the bacterial microenvironment, and the hunger treatment effect is achieved. The hollow mesoporous copper sulfide nanoparticles are prepared by adopting a one-pot hydrothermal method, synthesis raw materials are easy to obtain, and the method is simple and rapid. And the FBC-Cys and the GOx are loaded to the cavities and the surfaces of the copper sulfide nanoparticles through a physical adsorption effect. The multifunctional nano-drug can target bacterial cell walls, change the bacterial microenvironment, integrate photodynamic therapy and hunger therapy, and achieve a multifunctional antibacterial effect. The antibacterial hydrogel provided by the invention has excellent antibacterial effect and biocompatibility, and can play an excellent role in treatment of future bacterial infection.

The invention provides a weakly alkaline strontium-rich mineralized filter element with antibacterial property and a preparation method thereof, and relates to the technical field of water purification filter elements, the weakly alkaline strontium-rich mineralized filter element with antibacterial property comprises the following components by weight: 5-15 parts of modified celestite, 2-10 parts of modified strontianite, 2-5 parts of modified dolomite, 10-25 parts of modified medical stone, and 10-25 parts of modified zeolite, 5 to 15 parts of modified tourmaline, 2 to 10 parts of modified serpentine and 2 to 10 parts of modified wollastonite. After tourmaline is modified, weak current is generated by utilizing thermoelectricity and piezoelectricity to destroy bacterial cell membrane potential, so that the bacterial cell membrane potential is disordered, released negative ions change the physicochemical property of a bacterial living environment, the membrane permeability of bacterial cells is increased, and medical stone and zeolite are modified to release trace elements more easily. Bacterial cells which interfere with membrane permeability increase can be more quickly removed, the metabolism of bacteria is influenced, and the antibacterial effect is achieved.