1347results about How to "Improve the situation" patented technology

A data capture system utilizes a sensor with emitters adapted to transmit light into a fleshy medium and a detector adapted to generate intensity signals in response to receiving light after absorption by the fleshy medium. A monitor is configured to input the intensity signals, generate digitized signals from the intensity signals at a sampling rate and compute at least one physiological parameter responsive to magnitudes of the digitized signals. A data storage device is integrated with the monitor and is adapted to record data derived from the digitized signals on a removable storage media at the sampling rate.

An embodiment of the present disclosure seeks to smooth a perfusion index measurement through use of a baseline perfusion index measurement and / or through the use of multiple PI calculations. The combination of the baseline perfusion index measurement reduces an error between a calculated measurement of PI and actual conditions.

A system for imposing a filter between a vehicle driver's eyes and a source of light including at least one detector facing inward into a compartment in the vehicle toward a likely position of the head of the vehicle driver and arranged to obtain images of the eyes of the driver and a processor coupled to the detector(s) and arranged to determine the location of the driver's eyes based on analysis of the images obtained by the detector(s) and to obtain information about objects exterior of the vehicle providing sources of light from the images obtained by the detector(s) based on reflections off of the driver's eyes, i.e., the position of such objects. A filter, such as a pixelated screen, is imposed between the sources of light and the driver's eyes based on the location of the driver's eyes and the information about the exterior objects providing the sources of light.

An implantable stent having surface features adapted to promote an organized growth pattern of infiltrating cells when implanted in a tubular organ is provided. The surface features comprise depressions, pores, projections, pleats, channels or grooves in the stent body and are designed to increase turbulence or stagnation in the flow of a liquid, such as blood through the stent, and / or to promote the growth of infiltrating cells in an organized pattern. Alternatively, the invention stent can be populated with living cells prior to implant and can be heatable from an external source of energy, thereby inducing production of therapeutic bioactive agents from ingrowing cells. The invention also provides an implantable heatable stent for transcutaneously monitoring the flow of fluid through a lumen into which the stent is implanted by measuring the rate at which the heated stent cools in response to blood flow when the source of heat is removed.

Apparatus and methods are provided for providing access to a body lumen. The apparatus includes a tubular member including a proximal end, a distal end sized for insertion into a body lumen, and a lumen extending therebetween. A pushable stiffening member extends from the distal end of the tubular member. An expandable sheath extends along at least a portion of the stiffening member, the sheath being expandable from a contracted condition to facilitate insertion into a body lumen, and an enlarged condition wherein the sheath at least partially defines a lumen communicating with the tubular member lumen. A distal portion of the sheath is steerable, e.g., using a pull wire disposed within a lumen of the sheath or within the stiffening member. In addition or alternatively, the stiffening member may be biased to a predetermined shape to facilitate introduction.

Methods and compositions for treating, preventing, or diagnosing epidermal or dermal disorders, e.g., psoriasis, are disclosed. The methods and compositions of the invention use binding agents, e.g., antibodies, specific for the extracellular domain of human prostate specific membrane antigen (PSMA).

The invention provides an ankle prosthesis for use in the field of orthopedic prostheses comprising a talus implant for implanting in or on the talus and a top element including a tibia implant for implanting in or on the base of the tibia. The top element and the talus implant being mounted to move relative to each other by friction on a contact interface so as to allow the ankle to move. The contact interface presents a friction surface that can be considered as being a fraction of a substantially frustoconical surface. When implanted, the substantially frustoconical surface is oriented so that its larger radius portion is directed substantially towards the outside of the ankle.

Methods and devices for ablating portions of a tissue volume with electromagnetic radiation (EMR) to produce lattices of EMR-treated ablation islets in the tissue are disclosed, including lattices of micro-holes, micro-grooves, and other structures. Also, methods and devices for using the ablated islets are disclosed, including to deliver chromophores, filler, drugs and other substances to the tissue volume.

The disclosure relates to an improved method of enhancing nicotine concentrations in a gaseous carrier. The methods are adaptable to the delivery of nicotine for therapeutic effect in various diseases, in particular nicotine for tobacco product use cessation, substitution and / or harm reduction. The disclosure further relates various devices and device design principles for practicing these methods.

An extracardiac pumping for supplementing the circulation of blood, including the cardiac output, in a patient without any component thereof being connected to the patient's heart, and methods of using same. One embodiment provides a vascular graft that has a first end that is sized and configured to couple to a non-primary blood vessel and a second end that is fluidly coupled to a pump to conduct blood between the pump and the non-primary blood vessel. An outflow conduit is also provided that has a first end sized and configured to be positioned within the same or different blood vessel, whether primary or non-primary, through the vascular graft. The outflow conduit is fluidly coupled to the pump to conduct blood between the pump and the patient. The vascular graft may be connected to the blood vessel subcutaneously to permit application of the extracardiac pumping system in a minimally-invasive procedure.

What is described here is an antireflective coating comprising a carrier layer consisting of an optically transparent material, which, at least on one surface side, presents antireflective properties with respect the wavelengths of the radiation incident on the surface. Moreover, methods of producing the coating are described.The invention excels itself by the provision that the antireflective surface side presents a surface roughness with stochastically distributed structures-the so-called macro structures-and that the macro structures are additionally modulated with surface structures presenting a periodic sequence-the so-called micro structures-which present period or cycle lengths smaller than the wave lengths of the radiation incident on the antireflective surface.

The invention discloses a method for recycling a metal oxide from a waste flue gas denitration catalyst, comprising the following steps of: crushing the waste flue gas denitration catalyst to carry out pre-roasting pretreatment at high temperature; adding Na2CO3 into the waste flue gas denitration catalyst according to the proportion, mixing, pulverizing and roasting at high temperature to obtain a sintering block; crushing the sintering block and putting the crushed sintering block into hot water, and stirring and lixiviating to obtain titanate; adding sulphuric acid into the titanate, filtering, water-washing and roasting to obtain TiO2; adding the sulphuric acid into the lixiviated filtering liquid to regulate a pH value to 8.0-9.0; adding excessive NH4Cl for vanadium precipitation; decomposing NH4VO3 obtained from filtering at high temperature to prepare a V2O5 product; adding hydrochloric acid into the filtering liquid subjected to the vanadium precipitation to regulate a pH value to 4.5-5.0; adding CaCl2 for molybdenum and tungsten precipitation; treating the CaM0O4 and CaWO4, obtained from filtering, with the hydrochloric acid and roasting to obtain MoO3 and WO3. The method of the invention has the advantages of simple process and apparatus, high recycling efficiency, good product technical data, large treatment capacity and the like.

A multi-axis adjustable exercise machine which is pivotable about both a pitch axis and a roll axis with respect to a base for allowing an exerciser to perform a wide range of exercises on a pitched or rolled exercise machine. The multi-axis adjustable exercise machine generally includes an exercise machine which is adjustable with respect to a base. The exercise machine may be pivoted about a roll axis to adjust the roll angle of the exercise machine or may be pivoted about a pitch axis to adjust the pitch angle of the exercise machine. One or more actuators may be connected between the base and the exercise machine to effectuate the pivoting of the exercise machine about either or both axes with respect to the base.

Apparatus and methods are provided for providing access to a body lumen. The apparatus includes a tubular member including a proximal end, a distal end sized for insertion into a body lumen, and a lumen extending between the proximal and distal ends. A pushable stiffening member extends from the distal end of the tubular member, the elongate member terminating in a distal tip. An expandable sheath extends along at least a portion of the stiffening member, the sheath being expandable from a contracted condition to minimize a profile of the sheath to allow insertion along with the stiffening member into a body lumen, and an enlarged condition wherein the sheath at least partially defines a lumen communicating with the tubular member lumen. In one embodiment, the sheath includes an outer lumen and an inner lumen floating within the outer lumen, and the stiffening member is carried in the inner lumen.

An implantable stent having surface features adapted to promote an organized growth pattern of infiltrating cells when implanted in a tubular organ is provided. The surface features comprise depressions, pores, projections, pleats, channels or grooves in the stent body and are designed to increase turbulence or stagnation in the flow of a liquid, such as blood through the stent, and / or to promote the growth of infiltrating cells in an organized pattern. Alternatively, the invention stent can be populated with living cells prior to implant and can be heatable from an external source of energy, thereby inducing production of therapeutic bioactive agents from ingrowing cells. The invention also provides an implantable heatable stent for transcutaneously monitoring the flow of fluid through a lumen into which the stent is implanted by measuring the rate at which the heated stent cools in response to blood flow when the source of heat is removed.

An extracardiac pumping for supplementing the circulation of blood, including the cardiac output, in a patient without any component thereof being connected to the patient's heart, and methods of using same. One embodiment of the intravascular extracardiac system comprises a pump with inflow and outflow conduits that are sized and configured to be implantable intravascularly through a non-primary vessel, whereby it may positioned where desired within the patient's vasculature. The system comprises a subcardiac pump that may be driven directly or electromagnetically from within or without the patient. The pump is configured to be operated continuously or in a pulsatile fashion, synchronous with the patient's heart, thereby potentially reducing the afterload of the heart. In another embodiment, the system is positioned extracorporeally, with the inflow conduit and outflow conduit applied percutaneously to a non-primary vessel for circulating blood to and from the non-primary vessel or between the non-primary vessel and another blood vessel within the patient's vasculature.

A weather data aggregation and display system for displaying weather radar information to a pilot of a member aircraft of an airborne network of member aircraft. The weather data aggregation and display system includes an airborne network system (ANS) positioned on the member aircraft adapted to receive incoming geo-referenced weather data regarding Significant Meteorological Systems (SMS) from associated airborne network systems positioned on other member aircraft. A data processing system (DPS) is coupled to the airborne network system for generating the member aircraft's perspective of the SMS, based on the incoming weather data and the member aircraft's navigation and attitude information. The DPS provides DPS output weather data. An airborne display system (ADS) is positioned on the member aircraft and coupled to the data processing system. The airborne display system is adapted to receive the DPS output weather data and in response thereto display desired weather imagery of the Significant Meteorological Systems. The ANS is adapted to re-transmit the incoming geo-referenced weather data to associated airborne network systems positioned on other member aircraft.

A method and system that limits the use of a communication device present in an area controlled by an intelligent controller. The intelligent controller detects any present communication devices in the area and conducts an inventory providing information about each detected device. The intelligent controller compares that information to a standard of use data, which specifies the conditions need to be present for allowing the usage of a communication device. If such conditions are not met, the intelligent controller sends commands to the communication device to restrict its functionality. Else if, the intelligent controller is incapable of restricting the communication device, it can notify authorities of unauthorized usage of a communication device in the restricted area.

Disclosed herein are methods for treating a vascular leak disorder, hypotension, or a procoagulant state using angiopoietin-2 (Ang-2) antagonist compounds. Also disclosed are methods for treating a vascular leak disorder associated with high dose IL-2 therapy using angiopoietin-2 antagonist compounds. Methods for diagnosing and monitoring vascular leak disorders, hypotension, or a procoagulant state that include the measurement of Ang-2 polypeptide or nucleic acid levels are also disclosed. Methods for inducing a vascular leak using an Ang-2 agonist are also disclosed.

A free-space adaptive optical laser communication system having signal transmission and reception channels at all terminals in the communication system, wherein wavefront sensing (WFS) and wavefront correction mechanisms are employed along signal transmission and reception channels of all terminals in the communication system (i.e. adaptive optics) to improve the condition of the laser beam at the receiver (i.e. reduce the size of the spot a the detector plane). in the illustrative embodiment, the WFS mechanisms employ a novel WFS control process, in which active updating of reference positions and subaperture locations on the wavefront sensor. These WFS mechanism can be used in diverse application environments, including but not limited to FSO laser communication systems.

The present invention provides systems and methods for dynamic content management, the method including generating content associated with an object, dynamically adjusting the content associated with the object according to a user profile to form a user-defined object-based content package, displaying at least one captured image of the identified object on the device, and uploading the user-defined object-based content package associated with the identified object to the device simultaneously with the displaying step to provide dynamic content to the user on the device.

The invention relates to systems, methods, and associated devices for wirelessly communicating physiologic signals or other data in an electromagnetically noisy environment, such as a magnetic resonance imaging (MRI) suite. They permit wireless communication of data obtained from a sensor module attached to a patient while situated within the bore of an MR scanner. The system includes a first transceiver and a second transceiver. The first transceiver is linked to the sensor module for transmitting the data received therefrom. The second transceiver, which is connected to an apparatus remote from the first transceiver, is used to convey to the apparatus the data received from the first transceiver. The first and second transceivers enable the sensor module and the apparatus to communicate unidirectionally or bidirectionally without being adversely affected by, or adversely affecting, the operation of the MR system.

The invention relates to therapeutic conjugates with the ability to target various antigens. The conjugates contain a targeting antibody or antigen binding fragment thereof and an anthracycline chemotherapeutic drug. The targeting antibody and the chemotherapeutic drug are linked via a linker comprising a hydrazide moiety.

A method for electroblowing fibers is provided which involves the steps of: forcing a polymer fluid through a spinneret in a first direction towards a collector located a first distance from the spinneret, while simultaneously blowing a gas through an orifice that is substantially concentrically arranged around the spinneret, wherein the gas is blown substantially in the first direction; wherein an electrostatic differential is generated between the spinneret and the collector; and collecting the fibers, and its use in preparing submicron scale fibers of various types, particularly hyaluronan fibers, and the hyaluronan nanofibers thus formed.

The invention discloses a battery management system with balanced charge and discharge functions and a control method thereof, relating to a battery management system of a dynamic battery pack. The battery management system is structurally characterized in that a central processing unit (CPU) control unit is connected with a battery and relay set so as to detect the working condition of the battery and relay set; the CPU control unit and a balanced discharge module are successively connected with the battery and relay set so as to control the balanced discharge of the battery and the relay set; the CPU control unit, a balanced charge module and the battery and the relay set are successively connected so as to control the balanced charge of the battery and relay set; and a super-capacitor is connected with the balanced discharge module so as to store the discharge energy of the battery and relay set for supplying power for the battery management system. The battery management system can be widely applied to management of various battery packs such as a lead-acid battery, a lithium battery, a nickel-metal hydride battery and the like, supports the expansion of a lower computer, and can conveniently detect and monitor the conditions of multiple batteries.

The present invention relates to a pharmaceutical delivery device for application of a pharmaceutical to mucosal surfaces. The device comprises an adhesive layer and a non-adhesive backing layer, and the pharmaceutical may be provided in either or both layers. Upon application, the device adheres to the mucosal surface, providing localized drug delivery and protection to the treatment site. The kinetics of erodability are easily adjusted by varying the number of layers and / or the components.

The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide / microcarrier (IMP / MC) complexes. The IMP / MC complexes may be covalently or non-covalently bound, and feature a polynucleotide comprising at least one immunostimulatory sequence bound to a biodegradable microcarrier or noncarrier.

Biological macromolecules are synthesized in vitro under conditions and in a reaction composition wherein oxidative phosphorylation is activated and protein folding is improved.