825 results about "Folic acid" patented technology

The invention relates to a monoclonal antibody for detecting folic acid and a binding protein complex thereof or an antigen binding fragment thereof, and a preparation method and application thereof, the monoclonal antibody or the antigen binding fragment thereof comprises: (1) a heavy chain variable region having an amino acid sequence as shown in SEQ ID NO.1, SEQ ID NO.2 and SEQ ID NO.3, HCDR1, HCDR2 and HCDR3, and (2) a heavy chain variable region having an amino acid sequence as shown in SEQ ID NO.3; the light chain variable region is provided with an LCDR1, an LCDR2 and an LCDR3, and the amino acid sequences of the LCDR1, the LCDR2 and the LCDR3 are respectively shown as SEQ ID NO.4, SEQ ID NO.5 and SEQ ID NO.6. The monoclonal antibody or the antigen binding fragment thereof can bind folic acid and a protein compound thereof with high specificity and high affinity, so that the detection accuracy and sensitivity of folic acid are improved, the limitation that a traditional competition method detection reagent is low in sensitivity and poor in clinical correlation is broken through, and sandwich method immunodetection of folic acid is realized.

The invention provides a folate receptor targeting small molecule compound, a preparation method, a composition and application. Specifically provided is a compound represented by formula I or a pharmaceutically acceptable salt thereof. The compound or the pharmaceutically acceptable salt thereof provided by the invention can be used as a small-molecule targeting fluorescence contrast agent for assisting surgical treatment, has the advantages of novel structure, good solubility, small steric hindrance and strong targeting property, can obviously improve the view field of tumor surgery, and is beneficial to efficiently and accurately implementing excision of pathological tissues such as tumor tissues, boundary tissues and the like. # imgabs0 #

The invention relates to the technical field of liquid chromatography-mass spectrometry series connection, and particularly discloses a method for detecting folic acid metabolites of red blood cells through the liquid chromatography-mass spectrometry series connection technology. And an image analysis algorithm based on artificial intelligence and deep learning is utilized to extract a chromatographic separation state, so that gradient parameters are dynamically adjusted, the requirement of manual intervention is reduced, and the separation process of a target object in a complex matrix is favorably optimized. Particularly, key features in a chromatogram can be automatically identified and quantified based on a deep learning method, and gradient elution parameters are intelligently and dynamically adjusted according to the information, so that more optimized substance separation and detection can be realized. For example, if separation of a certain component is not ideal, the separation effect of the component can be improved by adjusting the proportion of the mobile phase B, so that the gradient elution process is optimized.

The invention discloses a fermentation medium for regulating and controlling a clostridium aerovorans target product and a fermentation method of the clostridium aerovorans target product. The medium comprises a basic component and a regulating component, the basic components comprise ammonium chloride, potassium chloride, magnesium sulfate heptahydrate, sodium chloride, monopotassium phosphate, yeast powder, calcium chloride dihydrate, sodium selenite, nickel chloride hexahydrate, biotin, folic acid, pyridoxine hydrochloride, thiamine, riboflavin, nicotinic acid, D-calcium pantothenate, cobalamin, para aminobenzoic acid and lipoic acid; the adjusting component comprises sodium tungstate, ferrous sulfate and sodium molybdate, sodium tungstate and ferrous sulfate have a forward adjusting effect on increasing the yield of acetic acid, ethanol and butanol in the target product, and sodium molybdate has a reverse adjusting effect on the target product. By optimizing the proportion of trace elements in the culture medium, the clostridium metabolism efficiency is improved, synthesis of a target product is regulated and controlled, and the method is particularly suitable for industrial production of acetic acid, ethanol, butanol and the like.

The invention discloses collagen polypeptide firming and anti-wrinkle freeze-dried powder, and relates to the technical field of cosmetics. The invention relates to a biological preservative which is prepared from water, butanediol, a bacillus / soybean fermentation product extract, soluble collagen, acetyl hexapeptide-8, panthenol, 1, 2, 4-trimethyl-1, 3-pentanediol and a proper amount of water. The cosmetic is prepared from 1, 2-hexanediol, tetrahydromethylpyrimidine carboxylic acid, hydroxypropyl tetrahydropyrantriol, tremella polysaccharide, saccharide isomeride, a bifidus yeast fermentation product lysate, sodium hyaluronate, DNA sodium, a radix gentianae extract, mannitol, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, oligopeptide-1, decapeptide-4, oligopeptide-3, hydrolyzed royal jelly protein, folic acid and disodium hydrogen phosphate. The additive is composed of sodium dihydrogen phosphate, citric acid and sodium citrate. The mask can provide rich nutrients for skin, deeply care the skin, moisturize and relieve the skin, tighten the skin, resist wrinkles and make the skin moisturized, glossy, elastic and tight, and is high in use safety and wide in application prospect.

Described herein are compounds, compositions, and methods for diagnosing and / or monitoring pathogenic disease using positron emission tomography. Also described are conjugates of the formula B-L-P, wherein B is a radical of a targeting agent selected from vitamin receptor binding ligands (such as folate), PSMA binding ligands, or PSMA inhibitors; L is a divalent linker comprising aspartic acid, lysine, or arginine, and P is a radical of an imaging agent or radiotherapy agent, such as a radionuclide or radionuclide containing group, or a radical of a compound capable of binding a radionuclide, such as a metal chelating group.

The compositions comprise at least two ingredients selected from the group consisting of fish oil, L-arginine, vitamin E, vitamin C, vitamin B3, vitamin B5, vitamin B6, vitamin B1, vitamin B2, folic acid, biotin, vitamin B12, and are formulated for the prevention and / or treatment of a disease or condition associated with muscle decline in a subject in need thereof. Preferably, the subject in need is an individual at risk of or having renal failure, renal dysfunction or / and nephropathy, such as chronic nephropathy, protein energy consumption, end-stage nephropathy, renal failure due to hospitalization in an intensive care unit, acute kidney injury, and the muscle decline is selected from the group consisting of muscle depletion, muscle loss due to renal failure or dysfunction, muscle decline associated with chronic kidney disease, muscle loss due to hospitalization in intensive care units during renal failure, metabolic acidosis during chronic kidney disease, protein energy depletion, or a combination thereof. The method enables the prevention and / or treatment of at least one outcome of a disease or condition associated with muscle decline in a subject at risk of or having renal failure, renal dysfunction or / and kidney disease. The composition and the method can be used to improve the level of at least one amino acid.

The invention provides a composition containing folic acid compounds and a near-infrared fluorescence capture system. The near-infrared fluorescence capture system comprises an imaging module, and the imaging module comprises a compound shown in the formula I or pharmaceutically acceptable salt of the compound. The compound shown in the formula I or the pharmaceutically acceptable salt of the compound can be used as a near-infrared fluorescence imaging agent, and is good in targeting property and clinical application prospect. # imgabs0 #

The embodiment of the invention provides breast cancer targeting nanoparticles as well as a preparation method and application thereof. According to the embodiment of the invention, the breast cancer targeting nanoparticles are synthesized by preparing the pH sensitive polymer, carrying out co-coupling modification on the pH response polymer and the folic acid albumin nano-carrier and utilizing a controlled desolvation method; the breast cancer targeting nanoparticle is combined with a nano preparation passive targeting strategy, a tumor microenvironment stimulation response strategy and a folic acid active targeting strategy, the effects of an EPR effect, PEG shedding, charge overturning, folic acid ligand-receptor combination and the like are utilized, precise targeting and specific response of tumors are achieved, and targeted accumulation of drugs in a tumor microenvironment is comprehensively improved. Therefore, the breast cancer targeting nanoparticles prepared by the embodiment have the advantages of high targeting property, drug controlled release, improvement of solubility and absorptivity of indissolvable drugs and the like, so that the curative effect of the drugs can be enhanced, the toxic and side effects can be reduced, and the breast cancer targeting nanoparticles have wide application prospects in the field of anti-tumor treatment.

This application relates to the field of food microbiology, and specifically discloses a Lactobacillus plantarum capable of producing 5-methyltetrahydrofolic acid, its fermentation method and application. A Lactobacillus plantarum inm30-LP capable of producing 5-methyltetrahydrofolic acid, with a preservation date of December 26, 2022, and the preservation unit is the General Microbiology Center of the China Committee for Culture Collection of Microorganisms, and the preservation number is CGMCC No. 26278. This application is based on the milk curd in the Gannan Tibetan area as the food source, isolates probiotics, and screens out Lactobacillus plantarum with high folic acid production from them. Moreover, the strain has obvious advantages over other lactic acid bacteria in terms of acid resistance and bile salt resistance, is suitable for growing in the gastrointestinal environment, has the ability to proliferate, has no antibiotic resistance, has antibacterial activity, and can produce bacteriocin.

The invention belongs to the field of drug-loaded nanoparticles, and provides a targeted drug-loaded nanoparticle with multiple responsiveness and a preparation method thereof. The targeted drug-loaded nano-particle with multiple responsiveness is prepared from poly (N-isopropylacrylamide-co-acrylic acid-co-N-acryloyloxy succinimide) nanogel with temperature and pH response characteristics, an anti-tumor drug and a folic acid layer capable of specifically targeting a folic acid receptor of a tumor cell, wherein the temperature and pH response characteristics are realized by the poly (N-isopropylacrylamide-co-acrylic acid-co-N-acryloyloxy succinimide) nanogel; the anti-tumor drug is loaded in the polymer network structure of the nanogel to form drug-loaded nanoparticles, the folic acid layer is composed of aminated folic acid molecules, the folic acid layer coats the drug-loaded nanoparticles, and amino groups of the aminated folic acid molecules are grafted on the surfaces of the drug-loaded nanoparticles. According to the invention, the preparation method of the existing chemotherapy nano-drug carrier can be simplified, the controllability of the preparation process is improved, the biocompatibility of the existing chemotherapy nano-drug carrier is improved, and the targeting property of the existing chemotherapy nano-drug carrier is enhanced.

The invention relates to the technical field of pharmaceutical preparations, in particular to a folic acid tablet with low oxidation impurities and a preparation method thereof, and discloses the folic acid tablet with low oxidation impurities, which comprises the following components: a mixture of folic acid and an antioxidant, a porous starch; wherein the mass ratio of the mixture of the folic acid and the antioxidant to the porous starch is (1-2): (3-4); the mass ratio of the folic acid to the antioxidant is 1: (1-3); the invention discloses a folic acid tablet with low oxidation impurities and a preparation method thereof, folic acid and an antioxidant tert-butylhydroquinone are mixed and crushed together, the folic acid can be fully wrapped by the antioxidant, oxidation of the folic acid is prevented or delayed, the particle size D90 of the mixture is controlled to be less than 5 [mu] m, then the mixture is fully mixed with porous starch, and the folic acid tablet with low oxidation impurities is prepared. By utilizing the porosity of the porous starch, the folic acid and the antioxidant can be adsorbed in concave holes of the porous starch, and meanwhile, the contact of the folic acid with oxygen and light is reduced, so that the generation of oxidized impurities in the long-term placement process is reduced.

The invention relates to the fields of biology, medicine and clinic. In particular to application of PAICS as a target spot in developing or screening reagents for preventing and / or treating orthopoxvirus infection, and application of inhibiting a synthetic pathway of purine nucleotide and / or inhibiting a metabolic pathway of folic acid in preparing reagents for treating and / or preventing orthopoxvirus infection diseases. In order to restrain the infection of orthopoxvirus, the inventor team uses a CRISPR / Cas9 technology to carry out generic genome screening on host cells infected by orthopoxvirus, determines a host-dependent gene PAICS gene in the orthopoxvirus infection process, and verifies and clarifies the virus-dependent mechanism of the gene; in order to deal with the global continuous orthopoxvirus infection problem, the invention plays an important role in the development and screening of future related prevention or treatment drugs, and also expands the new clinical application of existing drugs including methotrexate, mercaptopurine, mizoribine and the like.

The invention provides geranial dehydrogenase as well as a preparation method and application thereof, and relates to the technical field of biology, and the amino acid sequence of the geranial dehydrogenase is as shown in SEQ ID NO.1. Citral can be used as a substrate to catalytically synthesize the aromatic folic acid, and the conversion rate reaches 90%. The geranial dehydrogenase can be used for efficiently synthesizing the aromatic folic acid and can be used for biocatalytically converting the aromatic folic acid. Meanwhile, NAD < + > is used as a coenzyme to improve the enzymatic reaction efficiency, so that efficient catalytic synthesis of the aromatic folic acid is realized.

The invention belongs to the field of food, and particularly relates to application of a nutritional composition for assisting in improving memory ability. The invention provides application of a nutritional composition in preparation of food for assisting in improving memory ability of offspring. The nutritional composition comprises the following necessary components: active folic acid substances and fucosyllactose, moreover, in the nutritional composition, the mass ratio of the active folic acid substance to the fucosyllactose is (0.0001-0.0015): (0.5-10), the food is ingested by a mother to play the role of assisting in improving the memory ability of the offspring, the mother is in a gestation period and / or a lactation period, and the maternal is in the gestation period and / or the lactation period. The filial generation comprises a fetal-stage filial generation and / or an infant-stage filial generation and an optional child-stage filial generation. A large number of studies find that when active folic acid substances and fucosyllactose which are combined according to a certain proportion are supplemented to a mother at the beginning of the gestation period, the memory ability of offspring can be remarkably improved in an auxiliary mode.

The invention relates to the technical field of biological medicine, and discloses a culture medium for human metapneumovirus and application, the culture medium comprises the following components by mass: 850-920 parts of a basic culture medium; the metabolism reprogramming module is prepared from the following components in parts by weight: 0.05 to 0.15 part of 5-methyltetrahydrofolic acid, 0.3 to 0.7 part of N-acetyl-D-mannosamine and 1.0 to 3.0 parts of sodium dichloroacetate; the immune regulation and control module is prepared from 0.005 to 0.015 part of an RIG-I / MAVS pathway inhibitor; the receptor induction module is prepared from 0.5 to 1.5 parts of all-trans retinoic acid; the redox balance module is prepared from the following components in parts by weight: 0.1 to 0.5 part of pegylated superoxide dismutase and 0.002 to 0.008 part of sodium selenite. According to the method, the proportion of infectious virus particles can be remarkably increased, the generation of defective particles is reduced, meanwhile, the production cycle of host cells is prolonged, large-scale continuous culture is supported, and a high-quality and high-efficiency solution is provided for industrial production of gene therapy vectors and virus vaccines.

The invention relates to a probiotic stock solution capable of producing folic acid and SOD (superoxide dismutase) and having the functions of reducing uric acid and reducing blood sugar and a preparation method of the probiotic stock solution. Existing probiotic products are inconvenient to eat and do not have the effects of producing folic acid and SOD (superoxide dismutase). The probiotic stock solution contains the bifidobacterium animalis fermentation liquor, the lactobacillus paracasei fermentation liquor, the lactobacillus casei fermentation liquor, the lactobacillus fermentum fermentation liquor, the lactobacillus rhamnosus fermentation liquor and the lactobacillus reuteri fermentation liquor, and the final product is in a liquid state, can be packaged by small strip bags, and is relatively convenient to refrigerate, store and use. The probiotic stock solution disclosed by the invention not only has the effects of reducing uric acid and reducing blood sugar, but also generates water-soluble vitamin folic acid and superoxide dismutase SOD in the preparation and fermentation process, has the effects of resisting oxidation and aging after being taken into a human body, is suitable for pregnant women to take, and can reduce the risk of fetal neural tube defect.

The invention discloses a folic acid-polylactic acid double-layer vesicle delivery system for targeting MDSC cells in a focus and a preparation method and application of the folic acid-polylactic acid double-layer vesicle delivery system, the folic acid-polylactic acid double-layer vesicle delivery system comprises an inner-layer vesicle and an outer-layer vesicle, and a contrast agent is contained between the inner-layer vesicle and the outer-layer vesicle; the inner-layer vesicle is formed by self-assembling two block polymers, the outer wall of the inner-layer vesicle is positively charged, the inner-layer vesicle is compounded with an immunoregulation therapeutic gene through electrostatic interaction, the surface of the inner-layer vesicle is modified by an antibody targeting an MDSC cell surface marker, and a therapeutic drug is loaded in the inner-layer vesicle; the outer vesicle is formed by a liposome modified by targeted disintegration enzyme substrate polypeptide-PEG (Polyethylene Glycol). According to the double-layer vesicle delivery system, the delivery regulation range of the COX-2 inhibitor and folic acid targeted immunotherapy can be limited to local lesion placenta, the toxicity of immune drugs to pregnant women is effectively reduced, effective immunotherapy of placental diseases is made possible, the current situation that no treatment means are provided for placental dysfunction diseases is remarkably improved, and the application prospect is wide. A new thought is provided for effective immunotherapy of placenta dysfunction diseases.

The present disclosure relates to a field of biomedical technology. Embodiments of the present disclosure provide a leonurine nanocomposite hydrogel and preparation method and application thereof, including: dissolving dopamine (DA) monomers and inducing oxidation and self-polymerization of the DA to obtain polydopamine (PDA) nanoparticles, grafting thiol polyethylene glycol folic acid (SH-PEG-FA) on a surface of the PDA nanoparticles to obtain folic acid polydopamine (FA-PDA) nanocarriers; loading a leonurine (Leon) using the FA-PDA nanocarriers of the step 1 to obtain FA-PDA@Leon; encapsulating the FA-PDA@Leon of the step 2 into a gel matrix to obtain gel@FA-PDA@Leon hydrogel.

The invention belongs to the technical field of biological detection, and particularly relates to a method for synchronously and quantitatively detecting various folic acid metabolism related substances in trace plasma or serum, which comprises the following steps of: detecting a pretreated trace plasma or serum sample by adopting a liquid chromatography-tandem mass spectrometry method; the following nine folic acid metabolism related substances are synchronously and quantitatively detected: 5-formyl tetrahydrofolic acid, folic acid, 5-methyl tetrahydrofolic acid, S-adenosine-L-methionine, S-adenosine-L-homocysteine, vitamin B12, pyridoxamine, pyridoxine and pyridoxal. The invention further relates to application of the detection method in related detection of child neurodevelopment. According to the detection method, only trace plasma or serum is used, methotrexate is used for replacing an expensive isotope internal standard for more economical detection, and nine folate metabolism related substances can be accurately quantified at the same time. Therefore, the detection method disclosed by the invention has important clinical significance and wide market application prospect.

The invention relates to the technical field of cell culture. The invention provides a mesenchymal stem cell culture medium without animal-derived components and application of the mesenchymal stem cell culture medium. The culture medium comprises a basic culture medium and an additive, the additives comprise FGF-2, IGF-1, glutamine, folic acid, serotonin, cholesterol, arachidonic acid, an HEPES buffer solution, sodium bicarbonate, SCF, TGF-beta, PDGF, ascorbic acid and transferrin. The mesenchymal stem cell culture medium disclosed by the invention is completely free of animal-derived components, and meets the requirements of FDA / EMA clinical-grade cell therapy products. The culture medium can support high-density amplification of mesenchymal stem cells, the activity of passage cells is effectively improved, and the amplification time is shortened. The method has remarkable significance in improving the amplification efficiency of the mesenchymal stem cells and promoting and applying factory growth.

The present invention discloses a yellow-green fluorescent COFs material, its preparation method and application, belonging to the fields of covalent organic framework materials and analytical detection. In the present invention, 4,4',4'',4'''-(ethene-1,1,2,2-tetrayl)tetraphenylaldehyde (ETBA) and a flexible organic monomer 4,4'-diaminodiphenyl ether (ODA) with chelating sites are used as raw materials, methanol and acetic acid are added and shaken for dispersion, frozen with liquid nitrogen, evacuated and reacted in a constant temperature oven, the product is collected by filtration, washed with anhydrous N,N-dimethylformamide and tetrahydrofuran respectively, and then centrifuged and washed with anhydrous acetone, the solid product is collected, dried in an oven to obtain yellow ETBA-ODA-COF powder. The present invention regulates the π-π interaction in the COF structure, synthesizes a kind of ETBA-ODA-COF material with yellow-green fluorescence, and can establish a fluorescent nanoprobe to realize the analysis and detection of metal Fe 3+ , Hg 2+ ions and folic acid small molecules.

The invention discloses a feed for improving the flavor of broiler chickens and a preparation method of the feed, and belongs to the technical field of poultry feeds and feed preparation. Comprising the following components in parts by weight: 55 to 65 parts of basic ration, 35 to 40 parts of sea buckthorn pomace and bean dreg combined ferment, 3 to 5 parts of aquatic product leftover enzymatic hydrolysate, 3.5 to 4.0 parts of trehalose, 1.0 to 1.5 parts of ground cinnamon, 1.0 to 1.5 parts of xylooligosaccharide, 0.8 to 1.0 part of choline, 0.0001 to 0.0002 part of organic selenium and 0.01 to 0.02 part of folic acid. The mass ratio of the choline to the aquatic product leftover enzymatic hydrolysate is 1: (3.0-5.6); the mass ratio of the organic selenium to the sea buckthorn pomace and bean dreg combined fermentation product is 1: (58-100); the sea buckthorn pomace and bean dreg combined fermentation product is prepared by respectively pretreating sea buckthorn pomace and bean dregs and then carrying out aerobic, facultative and anaerobic continuous three-stage fermentation. The technical limitations that flavor substances of traditional feed are easy to inactivate and the utilization rate of agricultural by-products is low are broken through, and the breakthrough of flavor quality upgrading, efficient resource conversion and breeding benefit optimization is achieved.

Various benefits to intestinal health are made by delivery of an active agent to the colon of an animal, including a human. Active ingredients include of riboflavin, vitamin A, vitamin C, vitamin D, vitamin E, vitamin K, folic acid, β-carotene, vitamin B1, niacin, vitamin B5, vitamin B6, biotin, vitamin B12, omega-3 fatty acids and combinations thereof. Benefits include increased concentration of at least one short-chain fatty acid its salt thereof in the intestine, increased microbiome diversity in the intestine, increased beneficial bacteria in the intestine, increased the butyrate synthesis pathway in the intestine, improved barrier function of the intestine, reduced redox potential of the gut, reduced amount of gas produced in the intestine; and stimulation of intestinal immune responses.

The invention relates to an enzyme response antibacterial carbon dot and a preparation method and application thereof.The carbon dot takes a copper-doped carbon dot as a core and is covalently grafted with a hyaluronic acid shell layer through amidation reaction to form a composite nano material Cu-CDs (at) HA, specifically, soluble copper salt and folic acid are subjected to a hydrothermal reaction to obtain the copper-doped carbon dot, carboxyl is activated through EDC / NHS in a buffer system, and the carbon dot is prepared. And performing grafting reaction with hyaluronic acid to obtain a target product. The hyaluronidase-containing antibacterial composition can be specifically degraded and release antibacterial components under the action of hyaluronidase, shows good bacterial responsive bactericidal performance, has the minimum inhibitory concentrations of 8 g / mL and 16 g / mL for staphylococcus aureus and escherichia coli respectively, and has peroxidase-like activity and free radical scavenging capacity. The antibacterial carbon dots can be used for preparing intelligent wound dressings, antibacterial coatings and other biomedical materials, and have the advantages of responsive drug release, efficient antibacterial property and promotion of wound repair.

The use of a nutritional composition in the preparation of a food product for assisting in improving the memory ability in offspring, wherein the nutritional composition contains the following essential components: an active folic acid substance and fucosyllactose; and in the nutritional composition, the mass ratio of the active folic acid substance to the fucosyllactose is (0.0001-0.0015):(0.5-10). The food product exerts the effect of assisting in improving the memory ability in offspring, wherein the food product is ingested by a mother, the mother is preganant and / or lactating, and the offspring comprises fetal offspring and / or infant offspring and optionally childhood offspring.

The invention discloses a dendrobium officinale cold-resistant agent and application thereof. The active ingredient of the cold-resistant agent is folic acid and / or fulvic acid. Folic acid and fulvic acid are applied to cold-resistant treatment of dendrobium officinale for the first time, the innovation breaks through the limitation that a traditional cold-resistant agent is complex in component and possibly contains hormone or pesticide components, and a new, safer and more effective choice is provided for cold-resistant treatment of dendrobium officinale. The cold-resistant agent disclosed by the invention not only improves the survival rate of the dendrobium officinale in a low-temperature environment, but also remarkably reduces the damage degree of the appearance of the dendrobium officinale compared with a control group without using the cold-resistant agent, which shows that the cold-resistant agent disclosed by the invention has a remarkable effect on protecting the dendrobium officinale from low-temperature damage. The cold-resistant agent disclosed by the invention is simple in preparation process, easily available in raw materials and relatively low in cost, so that the cold-resistant agent has a wide application prospect in the fields of large-scale planting and deep processing of dendrobium officinale.

An antitumor pharmaceutical composition including (i) a fluoropyrimidine, (ii) a B6 vitamer, and (iii) a folate for its use in the treatment of cancer in a subject in need thereof. The antitumor pharmaceutical composition may be for a simultaneous, separate, or sequential use for the treatment of cancer, and may be administered sequentially or concomitantly with one or more immunotherapeutic, chemotherapeutic or radiotherapeutic agent.

The invention discloses a sheep colostrum composite powder composition capable of improving immunity and a preparation method of the sheep colostrum composite powder composition, and belongs to the technical field of milk composite powder. Comprising the following components in parts by weight: 15 to 20 parts of compound microcapsule probiotics, 200 to 300 parts of sheep colostrum dry powder, 20 to 25 parts of dissolution promoting polypeptide, 0.005 to 0.009 part of vitamin A, 0.003 to 0.006 part of vitamin D, 0.008 to 0.01 part of ascorbic acid, 0.003 to 0.005 part of vitamin K1, 0.006 to 0.009 part of vitamin B2 and 0.002 to 0.004 part of folic acid. According to the preparation method, the technical effects that the dissolution speed is increased, and caking and precipitation are not prone to occurring are achieved in a mode of preparing the dissolution-promoting polypeptide.

The present invention relates to a composition containing Citrus sinensis (L.) Osbeck fruit and lemon extracts and preferably a trace element, which is preferably a mineral such as Chromium, Calcium, Magnesium, Iron, Copper, Zinc, Iodine, Manganese, Potassium, Sodium, Selenium, Molybdenum, Fluoride, Chloride or Phosphorus or combinations thereof, and their salts and / or a vitamin such as A, D, E, K, B1, B2, C, Niacin, Pantothenic acid, B6, Folic acid, B12 or Biotin or combinations thereof.