77 results about "Folic acid" patented technology

The embodiment of the application discloses a preparation method of a target temperature-sensitive drug-loaded composite microsphere based on attapulgite, which comprises the following steps: carrying out purification treatment on original attapulgite based on an aqueous solution of inorganic strong acid to obtain purified attapulgite; mixing the purified attapulgite, gypenoside, inulin and folic acid to obtain a mixture, and carrying out mixing treatment on the mixture based on deionized water to obtain a composite microsphere suspension; conveying the composite microsphere suspension into a spray dryer to carry out granulation to obtain primary drug-loaded composite microspheres; adopting a melt impregnation method to coat lauric acid on the surface and pores of the primary drug-loaded composite microspheres, and cooling the primary drug-loaded composite microspheres coated with lauric acid to room temperature to obtain the target temperature-sensitive drug-loaded composite microspheres. The application can not only realize temperature change-based on-off type control release of drugs, significantly improve the targeting and treatment accuracy of drugs, but also reduce the systemic toxic side effects of chemotherapy from the source, and realize efficient and low-toxicity synergistic treatment.

This invention relates to the field of pet care product technology, and discloses a pet oral care spray and its preparation method. The preparation method employs a low-temperature gradient stepwise dissolution process: glucose oxidase is pre-dissolved at low temperature to obtain pre-solution A; bovine colostrum powder and lactoferrin are dissolved at low temperature to obtain protein pre-solution B; honey, folic acid, and vitamin D3 are dissolved at room temperature to obtain excipient pre-solution C; lysozyme is added to protein pre-solution B and stirred to dissolve; then pre-solution A and excipient pre-solution C are combined sequentially, the pH is adjusted, and purified water is added to make up the volume; the mixture is filtered through a microporous membrane for sterilization, and then filled and sealed under inert gas protection. This preparation method effectively protects the biological activity of each active protein and enzyme, achieving a long shelf life without the need for additional chemical preservatives. The resulting spray does not contain irritating ingredients such as alcohol and menthol, and is suitable for improving stomatitis, inhibiting plaque and tartar, and alleviating halitosis in pets of all ages and breeds.

Compositions and methods for treating diseases that are responsive to the coadministration of AKG and certain B vitamins are described herein. In addition, compositions and methods for treating host animals that may not respond to AKG monotherapy, including treating host animals having inadequate or dysfunctional expression of enzymes involved in vitamin B metabolism and homeostasis, such as methylenetetrahydrofolate reductase (MTHFR), are described herein.

This invention is related to the fields of medical biotechnology, nanobiotechnology, and nanomedicine. It involves a nanomedicine product that can release HOC1 (hypochlorous acid) at the tumor site in a controlled manner to treat lung cancer. HOC1 is a potent antimicrobial and antitumor agent that can target tumor tissues while minimizing damage to healthy tissues. The produced nanoparticles have a two-layer structure: the inner layer contains alginate, PFP (perfluoropentane), and Ca(OCl)2 to release HOC1, and the outer layer has a chitosan coating with folate and salicylic acid for targeting and proton release. The production process involves nanoemulsion and coating with the ionic gelation technique. When the nanoparticles are delivered to the lungs and targeted to cancer cells with folate, ultrasound radiation triggers the release of HOC1 to induce apoptosis and destroy cancer cells effectively, reducing side effects and improving treatment outcomes for lung cancer patients.

This invention relates to the field of pharmaceutical application technology, and more specifically, to the application of heterocyclic compounds. Example I describes the application of the compound shown in Formula I in the preparation of an inhibitor that inhibits the activity of methylenetetrahydrofolate reductase. Furthermore, the compound shown in Formula I can be used alone, in combination with para-aminosalicylic acid, or in combination with a β-lactamase inhibitor, all of which exhibit good antibacterial activity against Mycobacterium tuberculosis, and can treat or prevent diseases caused by Mycobacterium tuberculosis, such as tuberculosis.

This invention discloses an oral liquid for middle-aged and elderly men to cleanse blood, protect the brain, and promote hair growth, as well as its preparation method, belonging to the field of functional health food technology. Each bottle contains 50ml net content, one bottle daily, and is free of eight major allergens. The ingredients include resistant dextrin, erythritol, DHA algal oil microcapsule powder, phosphatidylserine, natto freeze-dried powder, various medicinal and edible extracts, ginseng, vitamins, folic acid, and purified water. This invention upgrades a solid beverage into an easily absorbed oral liquid dosage form, which is rapidly absorbed, does not harm the stomach and intestines, and can cleanse blood vessels, purify blood, assist in regulating blood pressure, blood sugar, and cholesterol, prevent and intervene in Alzheimer's disease, improve memory, and promote hair growth and darkening. The production process is mature and stable, suitable for industrial production, and is specially designed for middle-aged and elderly men, making it safe for long-term consumption.

This invention discloses a folic acid receptor-targeting compound and its uses, belonging to the field of pharmaceutical technology. The folic acid receptor-targeting compound is a compound of formula (I), its stereoisomer, its crystalline hydrate, its deuterated derivative, its solvate, its prodrug, or a pharmaceutically acceptable salt thereof: [target]-(L x ) s -R x (I), where [target] is a folic acid receptor-binding ligand; R x The chelating group is Ch or the prosthetic group is PG; s is an integer from 1 to 10; L x It contains at least one L 3 and with AA, L 1 L 2 or L 3 Arbitrary combinations are possible. The folic acid receptor-targeting compounds of this invention have low KD values ​​and strong affinity between the ligands and receptors, and can be used as folic acid receptor-targeted radiotherapy agents for imaging, diagnosis, and treatment of folic acid receptor (FR)-expressing tumors or cells.

A composition for improving cognitive performance, enhancing mental clarity, increasing focus, and increasing physical and mental energy is disclosed. The composition includes sufficient amounts of Fermented Green Tea Extract, L Theanine, and Caffeine, Ashwagandha Extract, Black Pepper Extract, Huperzine, Fermented Alpha GPC / Citoline Matrix, Turmeric Root Extract, Lions Mane Extract, Ginkgo Biloba Powder Extract, Panax Ginseng Extract, Rhodiola Extract, Cognitive Probiotic Blend, Folic Acid, Vitamin D3, Vitamin C Powder, Vitamin B12, Vitamin B6, Pantothenic Acid, Vitamin B3 Crystalline Powder, Vitamin B2 Powder, Vitamin B1 HCL, and Biotin.

This invention provides a composition containing vitamins and minerals, comprising vitamin D, folic acid, vitamin B12, potassium, and excipients in specific proportions. The invention may also include vitamin B1 and vitamin B2. The components of this composition have a synergistic effect in preventing hypertension, particularly in preventing hypertension accompanied by elevated homocysteine ​​levels. Furthermore, this composition can also be used for targeted nutritional supplementation in specific populations.

This disclosure generally relates to compounds, compositions, and methods for treating various diseases and conditions using therapeutically effective amounts of compounds of formula (I) or formula (II), pharmaceutically acceptable salts thereof, or derivatives thereof. This disclosure generally relates to compounds, compositions, and methods for treating various diseases and conditions, and more specifically, for treating fibrosis and atopic dermatitis (AD), as well as various other diseases and conditions related to neutrophil migration. Embodiments described herein relate to compounds, compositions, and methods for treating and / or preventing fibrosis and various fibrous diseases, disorders, or conditions. TIFF2026521119000072.tif43165

This application proposes a traditional Chinese medicine composition and preparation method for treating atrophic gastritis of spleen deficiency and blood stasis type, involving the field of traditional Chinese medicine. It utilizes Bupleurum chinense, stir-fried Paeonia lactiflora, Citrus reticulata peel, Pinellia ternata, Codonopsis pilosula, Poria cocos, stir-fried Atractylodes macrocephala, prepared Glycyrrhiza uralensis, Agrimonia pilosa, and Curcuma zedoaria, and establishes a water extraction and decoction preparation process. A rat model of precancerous gastric lesions was established using MNNG combined with multiple factors. Normal control group, model group, folic acid group, and traditional Chinese medicine group were set up to observe the morphological and pathological changes of the gastric mucosa. The results showed that the traditional Chinese medicine composition can reduce gastric mucosal atrophy, inflammatory cell infiltration, and fibrous tissue hyperplasia, alleviate intestinal metaplasia, downregulate the expression of AKT and mTOR proteins in the gastric mucosa, and inhibit abnormal mucosal proliferation. Its effect is superior to that of folic acid, providing experimental evidence for clinical treatment.

The application relates to the technical field of medicines, and discloses a composition of raltitrexed and a preparation method thereof. The composition of raltitrexed is a full-biodegradable amphiphilic polymer with hydrophilic chitosan and hydrophobic polylactic acid grafted as a carrier, and the composition is combined with carbon nanotubes and chitosan through pi-pi interaction and electrostatic adsorption. The carbon nanotubes have a large specific surface area and strong adsorption capacity, the folate has a targeting function, and the polylactic acid long chain has hydrophobicity. The raltitrexed drug is embedded in the micelle core of the copolymer, so that the encapsulation rate is greatly improved. The raltitrexed molecule contains O, N, S and other elements, can easily form a hydrogen bond with the amphiphilic copolymer, the hydrophobic end polylactic acid side chain can prolong the drug release time, achieve the purpose of slow release, reduce the drug toxicity and adverse reactions, the prepared composition is relatively stable in release, and the slow release effect is relatively ideal.

The present disclosure provides compositions and methods for providing a health benefit to a growing animal comprising administering a food composition to the animal, wherein the food composition includes a brain development blend. The brain development blend generally comprises DHA, EPA, taurine, choline, thiamine, riboflavin, pantothenic acid, niacin, pyridoxine, vitamin B12, and folic acid.

This invention discloses a FA-ICG-NBs nanobubble, its preparation method, and its application in the preparation of tumor-targeted therapeutic agents. The FA-ICG-NBs nanobubble employs a composite phospholipid shell, with folic acid (FA) covalently bonded to the surface and indocyanine green (ICG) loaded onto it, encapsulating a mixture of oxygen and sulfur hexafluoride. The preparation method includes: preparing a lipid solution for forming the composite phospholipid shell; mixing the lipid solution with the oxygen and sulfur hexafluoride mixture, and then performing a reciprocating shearing gas-liquid interface self-assembly to obtain the FA-ICG-NBs nanobubble. The FA-ICG-NBs nanobubble prepared by this invention utilizes dual-wavelength photoacoustic imaging for non-invasive assessment of tumor blood oxygenation and hypoxia improvement, combined with ICG fluorescence timing for screening the optimal therapeutic window, and synergistic oxygen-enhanced sonodynamic therapy. It exhibits good biocompatibility, structural stability, and integrates targeted enrichment, blood oxygenation assessment, hypoxia monitoring, timing regulation, and enhanced therapeutic effects.

This invention provides an application of *Lactobacillus paracasei* IOB413 metabiotic and its composition in gastric cancer, belonging to the field of microbial technology. *Lactobacillus paracasei* IOB413 has the preservation number CGMCC No. 16022. Its metabiotic can inhibit gastric cancer progression by suppressing epithelial-mesenchymal transition in tumor cells and regulating the IL-6 / JAK2 / STAT3 signaling pathway. The composition with folic acid has a synergistic effect, more effectively reducing tumor volume and lowering the levels of pro-inflammatory factors and tumor markers. It has high safety and is suitable as an adjuvant therapy before and after gastric cancer surgery, providing a new approach to gastric cancer treatment.

This invention discloses an S-estrol composition for delaying ovarian aging and its uses, relating to the fields of biomedicine and health products. The S-estrol composition for delaying ovarian aging comprises, by weight, the following components: 1-5 parts S-estrol, 2-8 parts soy isoflavones, 3-10 parts coenzyme Q10, 2-6 parts vitamin E, 4-12 parts vitamin C, 0.01-0.05 parts folic acid, 0.1-0.3 parts zinc source, 0.5-1.5 parts anti-aging protective agent, 50-80 parts carrier, and 10-15 parts purified water. This invention uses high-purity S-estrol as the core, combined with soy isoflavones, coenzyme Q10 and a variety of antioxidant nutrients in a scientific formulation to form a synergistic system for estrogen receptor signal regulation and antioxidant defense. By constructing a complex antioxidant network and introducing novel anti-aging protectants for synergistic effect, the activity of antioxidant enzymes tends to increase and the level of lipid peroxidation tends to decrease, thereby improving the oxidative stress state in ovarian cells as a whole.

The present application relates to a kind of drug composition for preventing and adjuvant therapy of Alzheimer's disease and preparation method thereof, belong to medical health technical field.The prescription of the drug composition prepared in the present application includes the following active ingredients, phosphatidylserine, pyrrole quinoline quinone, coenzyme Q10, curcumin, EGCG, alpha-lipoic acid, acetyl L-carnitine, magnesium threonate, vitamin E, folic acid and vitamin B12.The preparation method of the drug composition also includes the following steps: the product is loaded with energy by weak magnetic resonance equipment to the composition.The drug composition reaches the effect of antioxidation, anti-inflammation, improves cerebral blood flow and protects neuron by the synergistic effect of multiple functional components, so as to help slow down the progress of Alzheimer's disease.

This invention relates to the field of sports nutrition food technology, and discloses a multivitamin formula and its preparation method, comprising the following components in parts by weight: 1.8-2.2 parts of mannose oligosaccharide, 1.8-2.2 parts of galacose oligosaccharide, 9-11 parts of xylooligosaccharide, 6.5-7.5 parts of fructooligosaccharide, 8.5-9.5 parts of maltitol, 1.8-2.2 parts of erythritol, 2.8-3.2 parts of galacose-mannan, 1.8-2.2 parts of stachyose, 13-15 parts of inulin, 38-42 parts of resistant dextrin, 0.20-0.24 parts of vitamin C, 0.45-0.55 parts of silicon dioxide, 0.010-0.014 parts of vitamin B1, and vitamin B2. 0.005-0.007 parts, folic acid 0.0009-0.0011 parts, γ-aminobutyric acid 0.45-0.55 parts, tyrosine 3.8-4.2 parts, magnesium lactate 3.8-4.2 parts; This invention forms a complex prebiotic system by simultaneously adding eight kinds of dietary fiber / oligosaccharides: resistant dextrin, inulin, xylooligosaccharide, fructooligosaccharide, galactooligosaccharide, mannose, galactomannan, and stachyose, which comprehensively regulates the intestinal flora and promotes the production of short-chain fatty acids.

Disclosed are method of treating a subject in need thereof comprising applying an alternating electric field, at a frequency for a period of time, to a target site of the subject in need thereof; and administering a combination of leucovorin calcium, fluorouracil, irinotecane hydrochloride, and oxaliplatin to the subject in need thereof. Disclosed are methods of reducing viability of cancer cells comprising applying an alternating electric field, at a frequency for a period of time, to a population of cancer cells; and contacting the population of cells with a combination of leucovorin calcium, fluorouracil, irinotecane hydrochloride, and oxaliplatin. Disclosed are methods of increasing apoptosis of cancer cells comprising applying an alternating electric field, at a frequency for a period of time, to a population of cancer cells; and contacting the population of cancer cells with a combination of leucovorin calcium, fluorouracil, irinotecane hydrochloride, and oxaliplatin. Disclosed are methods of reducing the number of cancer cells comprising applying an alternating electric field, at a frequency for a period of time, to a population of cancer cells; and contacting the population of cancer cells with a combination of leucovorin calcium, fluorouracil, irinotecane hydrochloride, and oxaliplatin.

The application discloses a kind of sea cucumber peptide with antitumor activity and ginsenoside composition preparation method and its application, it is related to biological activity material complex technical field, composition includes directional enzymatic sea cucumber oligopeptide, biotransformation rare ginsenoside and tumor microenvironment response carrier;Sea cucumber oligopeptide is proportioned with Rg3, Rh2, Compound K, Rk1, Rg5 and the like saponin, and is loaded by hyaluronic acid / folic acid modified disulfide bond crosslinking chitosan-lipid carrier, is accelerated release under weak acid, high glutathione or hyaluronidase condition.This composition has good stability and delivery efficiency, and can be used for antitumor auxiliary preparation, functional food and combined drug research.

The application provides an antitumor drug, a preparation method and application thereof, and belongs to the technical field of medicines. 4 The Fe3O NPs are deposited with polydopamine on the surface, then a COF layer is formed on the surface through a one-pot method, and an antitumor compound is loaded; further, doxorubicin is loaded on the surface, and then the antitumor drug is prepared by reacting with F127 coupled with folate and oligomeric hyaluronic acid. The antitumor drug prepared by the application has high anticancer activity and drug resistance reversal, high drug loading rate, is not prone to aggregation, has good biocompatibility, good targeting and slow release, and has good application in chemotherapy, photodynamic therapy, photothermal therapy and nuclear magnetic imaging, so that the antitumor drug becomes a new generation of diagnosis and treatment integrated reagent.

This invention belongs to the fields of pharmaceutical raw material preparation and compound preparation, specifically relating to a method for preparing calcium folinate. The method includes: irradiating folic acid in a solvent with low light intensity in the presence of a photocatalyst and hydrogen donor I to achieve a first-stage hydrogen transfer reduction; after the concentration of dihydrofolate in the system reaches its peak, adding hydrogen donor II for high-intensity irradiation to achieve a second-stage hydrogen transfer reduction; then stopping the irradiation and sequentially performing a formylation reaction and a calcium salt precipitation reaction to obtain calcium folinate. The method provided by this invention not only enables a one-pot reaction but also improves the yield of calcium folinate, showing broad application prospects.

The present application relates to a kind of natural (6S) -5-methyl tetrahydrofolate and its preparation method, wherein the natural (6S) -5-methyl tetrahydrofolate is prepared by reducing process with folic acid as raw material, and no heavy metal such as platinum or lead, and formaldehyde, benzene sulfonic acid and its ester and other raw materials are used in production process;The content of the natural (6S) -5-methyl tetrahydrofolate is not less than 98%, the amount of JK12A is not higher than 0.1%, methyl tetrahydropterin is not detected, benzene sulfonic acid and its ester are not detected, and enzyme protein residue is not higher than 1 ng / g;The present application has the advantages of convenient post-processing, green environmental protection, high product purity and the like due to the use of green biological production process.

This invention discloses a fluorescent molecule targeting the folic acid receptor, its preparation method, and its applications. This invention provides a compound as shown in formula (I), its pharmaceutically acceptable salt, or its tautomer. The compound of this invention can be used as a fluorescent contrast agent in near-infrared surgical navigation.

The present invention relates to orally administrated compositions suitable for supporting women with premenstrual syndrome, which compositions contain: a) stereoisomers of inositol that contribute to the normal function of the ovaries, specifically myoinositol and D-chiro-inositol in a ratio of myoinositol: D-chiro-inositol from 2:1 to 5:1; b) vitamins of the B complex that contribute to normalpsychological function, preferably folic acid and / or vitamin B2 and / or vitamin B6 and / or vitamin B12; c) osier extract and / or Rooibos extract that contribute in normal psychological function; d) N-acetylcysteine and e) one or more inactive excipients.

The application discloses a lung adenocarcinoma recurrence prediction method and system based on multi-omics data analysis, relates to the technical field of precision medicine, and comprises the following steps: collecting folate metabolism group data, a transcription group expression spectrum and methylation level data of a target gene promoter region of tumor tissue of a lung adenocarcinoma patient; constructing a metabolism-epigenetic correlation topology graph based on a spatial adjacent relationship, screening a significant causal relationship between methylation variation and metabolism fluctuation through causal analysis, and generating a methylation metabolism significant causal edge set; fusing simulation metabolism channel characteristics and the methylation metabolism significant causal edge set, constructing a lung adenocarcinoma recurrence risk prediction model, triggering a high-risk early warning signal through time sequence analysis of risk factor fluctuation; through the construction of the metabolism-epigenetic correlation topology graph and the screening of the significant causal edge set, the causal correlation modeling of multi-omics data in the spatial dimension is realized, the robustness of the recurrence prediction model is improved, the prediction performance is synergistically enhanced, and the accuracy of lung adenocarcinoma recurrence prediction is significantly improved.

The application relates to the technical field of microbial culture medium, and discloses a chemical component limited culture medium for supporting growth of bifidobacterium and application thereof. The CDM comprises a carbon source, salts, amino acids, vitamins and water; the carbon source is selected from at least one of glucose, fructose, lactose, maltose and galactooligosaccharide, the salts comprise sodium acetate, potassium hydrogen phosphate, ammonium acetate, magnesium sulfate heptahydrate, ferrous sulfate heptahydrate, sodium chloride and manganese sulfate monohydrate, the amino acids comprise alanine, cystine, cysteine, tryptophan and asparagine, and the vitamins comprise pyridoxine hydrochloride, nicotinic acid, calcium pantothenate, thiamine hydrochloride, riboflavin, p-aminobenzoic acid, folic acid and biotin. The CDM of the application is a liquid culture medium, only comprises 21 definite components, is simple in components, convenient in preparation, and is high in universality, and can effectively support growth of bifidobacterium.