66 results about "Ribitol" patented technology

The invention describes a pharmaceutical composition and method for treating cancer comprised of A) 2,3-dimethoxy-5-methyl-1,4-benzoquinone and / or B) at least one of wild yam root, teasel root, balm of gilead bud, bakuchi seed, dichroa root, kochia seed, kanta kari, bushy knotweed rhizome, arjun, babul chall bark, opopanax and bhumy amalaki; optionally one or more of frankincense, garcinia fruit, vitex, dragons blood, mace, sage and red sandalwood with at least c) one compound capable of maximizing oxidative mitochondrial function preferably riboflavin or vitamin B2 derivatives, FAD, FMN, 5-amino-6-(5′-phosphoribitylamino)uracil, 6,7-Dimethyl-8-(1-D-ribityl)lumazine, ribitol, 5,6-dimethylbenzimidazole, tetrahydrobiopterin, vitamin B1, lipoic acid, biotin, vitamin B6, vitamin B12, folate, niacin, vitamin C and pantothenate and / or d) at least one lactic acid dehydrogenase inhibitor (preferably 2′,3,4′5,7-pentahydroxyflavone) and optionally f) an alkalizing agent (aloe vera, chlorella, wheat grass, sodium or potassium bicarbonate, potassium) g) an antiproliferative herb (speranskia or goldenseal) and h) a pharmaceutically acceptable carrier.

The invention describes a nutraceutical composition and method for preventing / treating cancer comprised of A) quinones (2,3-dimethoxy-5-methyl-1,4-benzoquinone, thymoquinone, tocopherolquinone) B) compounds capable of maximizing oxidative mitochondrial function preferably riboflavin, FAD, FMN, 6,7-Dimethyl-8-(1-D-ribityl)lumazine, ribitol, 5,6-dimethylbenzimidazole, tetrahydrobiopterin, vitamin B1, lipoic acid, biotin, vitamin B6, vitamin B12, folate, B3, C and pantothenate C) lactic acid dehydrogenase inhibitors; 2′,3,4′5,7-pentahydroxyflavone, epigallocatechin gallate, quercetin, citric acid, rosemary, black walnut, clove, nutmeg, licorice root, coriander, cinnamon, ginger root, myrrh gum and green tea D) alkalizing agents: aloe vera, chlorella, wheat grass, apple cider vinegar, burdock root, kudzu root, alfalfa, barley grass, spirulina, parsley leaf, calcium, magnesium, potassium or bicarbonate salts E) potent tumoricidal herbs; gromwell root, wild yam, beth root, teasel root, balm of gilead bud, frankincense, bakuchi seed, dichroa root, kochia seed, kanta kari, sweet myrrh, galbanum, garcinia fruit, mace, white sage and tumoricial plant derived constituents: gambogic acid, shikonin, diosmin or boswellic acid F) an antiproliferative herb (speranskia or goldenseal) and G) a pharmaceutically acceptable carrier.

This invention relates to a process for preparing alditol acetals, such as dibenzylidene sorbitols, monobenzylidene sorbitols, and the like, through the reaction of unsubstituted or substituted benzaldehydes with alditols (such as sorbitol, xylitol, and ribitol) in the presence of a mineral acid and at least one surfactant having at least one pendant group of 6 carbon chains in length. Such a reaction provides a cost-effective, relatively safe procedure that provides excellent high yields of alditol acetal product. Furthermore, such a specific reaction is also the best known procedure for the production of certain compounds which can be easily separated from other formed isomers. Additionally, such a procedure facilitates the production of certain asymmetric alditol acetal compounds and compositions in acceptable yields as well. Such alditol acetals are useful as nucleating and clarifying agents for polyolefin formulations and articles, as one example.

The present invention relates to a natural deodorant system and a natural system for topical and systemic delivery of active ingredients, both systems being primarily free of, preferably substantially free of, more preferably essentially free of, and most preferably completely free of ethoxylates or other petrochemical derivatives, and comprising: (a) at least one of (1) glycerine (preferably of plant origin), (2) a polyol selected from the group consisting of galactitol, erythritol, inositol, ribitol, dithioerythritol, dithiothreitol, (3) a sugar alcohol, selected from the group consisting of mannitol, sorbitol, xylitol and maltitol, (4) a hydrogenated starch hydrosylates of at least one of berries, apples or plums, and (5) mixtures thereof; (b) water or a lower monohydric alcohol, selected from the group of methanol, ethanol, propanol and isoproponal, or mixtures thereof, present at a combined concentration of at least 20%; (c) one or more carrageenans (preferably of plant origin) or alginates, or mixtures thereof, present in combined concentrations of less than about 2%; and (d) optionally, one or more thickeners or gums selected from the group consisting of tara, guar, xanthan, Arabic, tragacanth, agar, locust bean gum, ghatti and microcrystalline celluloses.

A non-clear (translucent to opaque) cleansing bar comprising: (a) from about 3 to about 40 weight % anionic soap; (b) from about 4 to about 40 weight % of at least one synthetic surfactant; (c) from 0.1 to about 10 weight % of a gelling agent from the group consisting of dibenzylidene sorbitol, dibenzylidene xylitol, dibenzylidene ribitol, and mixtures thereof; (d) from about 5 to about 60 weight % of a humectant provided that glycerin is a component of the humectant and is present in an amount of about 2 to about 10 weight %; and (e) water; wherein all amounts are in % by weight based on the weight of the entire composition.

This invention relates to a process for preparing alditol acetals, such as dibenzylidene sorbitols, monobenzylidene sorbitols, and the like, through the reaction of unsubstituted or substituted benzaldehydes with alditols (such as sorbitol, xylitol, and ribitol) in the presence of a mineral acid and at least one surfactant having at least one pendant group of 6 carbon chains in length. Such a reaction provides a cost-effective, relatively safe procedure that provides excellent high yields of alditol acetal product. Furthermore, such a specific reaction is also the best known procedure for the production of certain compounds which can be easily separated from other formed isomers. Additionally, such a procedure facilitates the production of certain asymmetric alditol acetal compounds and compositions in acceptable yields as well. Such alditol acetals are useful as nucleating and clarifying agents for polyolefin formulations and articles, as one example.

A novel article and method are disclosed for reducing malodor in disposable products for the absorption of body fluids. An effective amount of pentitol is applied to a disposable absorbent material, prior to its use. In one aspect, the invention provides a water-swellable, water-insoluble, hydrogel-forming polymeric absorbent material. In one aspect, the pentitol is compositionally part of the absorbent structure or is coated on the absorbent material present in the absorbent structure. The pentitol preferably is located in the area of insult, i.e., that area of the absorbent product to be exposed to the body fluid intended to be absorbed. The pentitol in the novel article and method of the present invention is a compound selected from the group consisting of ribitol, D-arabinitol, L-arabinitol, and xylitol or a combination of one or more compounds selected from the group consisting of ribitol, D-arabinitol, L-arabinitol, and xylitol effective in preventing malodor.

The present invention relates to the field of the Medicine, in particular with the chemical synthesis of oligosaccharide mixtures derived of ribose-ribitol-phosphate, which are used as active principle in vaccines for the prevention of infections caused by Haemophilus influenzae type b (Hib), as well as with the vaccines containing said oligosaccharide mixtures.The oligasaccharide mixtures obtained by chemical synthesis of the present invention, comprise repeating units of formulae (phosphate-ribosa-ribitol)n or (ribose-ribitol-phosphate)n of at least 5 compounds of structure A or B, which represent the repeating unit of the capsular polysaccharide of Haemophilus influenzae type b and differ only by n, being n a value contained between 4 and 25 (n>=4 y<=25), and wherein R1 or R2 is a spacer for conjugation to a carrier, with the condition of R1=spacer if R2=H, or R2=spacer if R1=H.The invention also is related with the immunogens containing such oligosaccharide mixtures, with the vaccines containing said immunogens and with the methods to prepare these oligosaccharides as mixtures. Furthermore, the invention includes the use of the vaccines, alone or combined with other vaccines, for the prevention of the infections caused by Haemophilus influenzae type b.

The invention describes a nutraceutical composition and method for preventing / treating cancer or augmenting chemotherapy in advanced stage malignancies; comprised of [1] tumoricidal herbs; beth root, galbanum, gromwell root, wild yam, balm of gilead bud, frankincense, [2] an antiproliferative herb; speranskia [3] a natural lactic acid dehydrogenase (LDH) inhibitor, 2′,3,4′5,7-pentahydroxyflavone or cinnamon, [4] alkalizing agents: calcium, magnesium, potassium or bicarbonate salts, barley grass, chlorella and spirulina [5] at least one quinone and [6] at least one agent capable of maximizing oxidative mitochondrial function preferably riboflavin, 6,7-Dimethyl-8-(1-D-ribityl)lumazine, ribitol, 5,6-dimethylbenzimidazole, tetrahydrobiopterin and a pharmaceutically acceptable carrier.

A novel article and method are disclosed for reducing malodor in disposable products for the absorption of body fluids. An effective amount of pentitol is applied to a disposable absorbent material, prior to its use. In one aspect, the invention provides a water-swellable, water-insoluble, hydrogel-forming polymeric absorbent material. In one aspect, the pentitol is compositionally part of the absorbent structure or is coated on the absorbent material present in the absorbent structure. The pentitol preferably is located in the area of insult, i.e., that area of the absorbent product to be exposed to the body fluid intended to be absorbed. The pentitol in the novel article and method of the present invention is a compound selected from the group consisting of ribitol, D-arabinitol, L-arabinitol, and xylitol or a combination of one or more compounds selected from the group consisting of ribitol, D-arabinitol, L-arabinitol, and xylitol effective in preventing malodor.

The invention provides methods and compositions for the production of L-ribitol and other rare sugars using a mannitol-1-dehydrogenase.

A hydrocatalyst for preparing N-(D)-deoxyriboseol-3,4-dimethylaniline as the intermediate in semi-synthesizing riboflavin is a novel alloy catalyst prepared from Raney Ni-catalyst through modifying by the transition metal elements of families I, II, IV, VI, VII and VIII chosen from Cu, Zn, Ti, Zr, Cr, Mo, Mn, Fe, Co, Ru, Rh, Pd and Pt. It contains Ni, Al and transition metal element in Wt. ratio of 1000:1000:(1-280). Its advantages are high activity, selectivity and output rate, low dosage and low cost.

Disclosed is a new and emerging serotype of Streptococcus pneumoniae designated serotype 6C, and assays and monoclonal antibodies useful in identifying same. Also disclosed is a novel pneumococcal polysaccharide with the repeating unit {2) glucose 1 (1→3) glucose 2 (1→3) rhamnose (1→3) ribitol (5→phosphate}. This new serotype may be included in pneumococcal vaccines.

The present invention relates to a vaccine composition for preventing staphylococcus aureus infection containing, as an active ingredient, a ribitol-phosphate which has been modified only by a β-configuration in N-Acetylglucosamine (GlcNAc), a repeating unit of the ribitol-phosphate, or a wall teichoic acid (WTA) containing the repeating unit. The composition according to the present invention contains a coupling motif (an epitope) for an anti-WTA antibody, and thus can be effectively used as a vaccine composition or to prevent staphylococcus aureus infection by generating anti-WTA antibody.

The invention relates to a method for using a simply processed waste erythritol mother liquor as a concrete retarder. The waste erythritol mother liquor which is generated in the erythritol fermenting production process mainly comprises medium components of glucose, mannan, monopotassium phosphate, citric acid and the like, and metabolic compounds of erythritol, glycerol, ribitol, other trace polyols and the like, and the waste erythritol fermentiion mother liquor which undergoes preliminary processing of impurity removal, anticorrosion, homogenization and the like can be applied to the retardation of concrete. Domestic and foreign tests and practical applications prove that saccharides of glucose, mannan and the like, hydroxycarboxylic acids of citric acid and the like, and inorganic salts of monopotassium phosphate and the like have good retardation effects, and the waste erythritol mother liquor has a good retardation effect and a certain water reducing effect on the concrete. A certain amount of the waste erythritol mother liquor can be added to the concrete to reach a required retardation effect. Raw materials of the waste rythritol mother liquor, which are from industrial wastes, have the characteristics of low cost, use convenience and the like, and play a role in energy saving, emission reduction and value creation.

Disclosed is a new and emerging serotype of Streptococcus pneumoniae designated serotype 6C, and assays and monoclonal antibodies useful in identifying same. Also disclosed is a novel pneumococcal polysaccharide with the repeating unit {→2) glucose 1 (1→3) glucose 2 (1→3) rhamnose (1→3) ribitol (5→phosphate}. This new serotype may be included in pneumococcal vaccines.

Novel compounds, called liamocins from Aureobasidium pullulans, having the general structure in Formula 1 are disclosed.where R1 is either COCH3 or H; and R2 is between two to ten O-linked 3,5-dihydroxydecanoate; and R3 can be a polyol (e.g., L- or D-glycerol, L- or D-threitol, L- or D-erythritol, L- or D-arabitol, L- or D-xylitol, L- or D-lyxitol, L- or D-ribitol, L- or D-allitol, L- or D-altritol, L- or D-mannitol, L- or D-iditol, L- or D-gulitol, L- or D-glucitol (also called sorbitol), L- or D-galactitol (also called dulcitol), and L- or D-talitol), 2-amino-D-mannitol, 2N-acetylamino-D-mannitol, L-rhamnitol, or D-fucitol; except when R3 is D-mannitol, R2 is not 2 nor 3 O-linked 3,5-dihydroxydecanoate chains. These liamocins described above in addition to D-mannitol liamocin A1, D-mannitol liamocin A2, D-mannitol liamocin B1, and D-mannitol liamocin B2, alone or in combination with each other, can be used to kill certain bacteria and to treat certain bacterial infections.

The invention provides dry compositions for preparing and loading a sample on a gel for electrophoretic separation. The dry compositions preferably include a tracking dye and a sedimenting agent selected from a five-carbon polyol (e.g., ribitol, arabitol, or xylitol), iso-erythritol, maltitol, and saccharine. Methods for making and using, as well as kits comprising the disclosed compositions, are also provided.

The invention relates to a method for detecting an organic acid, an amino acid and sugar in fermented liquid by gas chromatography-mass spectrometry, belonging to the technical field of biochemical examination and determination. The detection method comprises the following steps: (1) centrifuging taken fermentation liquid at a high speed and respectively collecting cells and extracellular fluid; (2) preparing a fermentation liquid sample: adding acetonitrile in a liquid supernatant prepared in the step (1) to remove protein; carrying out vortex shaking, and centrifuging and collecting liquid supernatant III; adding an internal standard substance ribitol solution and drying at a room temperature in vacuum to obtain an extracellular fluid sample II; (3) deriving the sample adding a sugar deriving agent and an amino acid deriving agent; and (4) carrying out the gas chromatography-mass spectrometry and data acquisition. The method provided by the invention has the advantages of simplicity in sample treatment, simplicity and convenience in operation, short detection time of organic acid, amino acid and sugar, high sensitivity, high repeatability of a detection result, capability of preparing a plurality of samples and the like.

The present invention provides a method of treating a disorder associated with muscle weakness in a subject, comprising administering to the subject a controlled-release composition comprising an effective amount of ribitol and / or ribose, thereby treating the disorder associated with muscle weakness.

The invention provides dry compositions for preparing and loading a sample on a gel for electrophoretic separation. The dry compositions preferably include a tracking dye and a sedimenting agent selected from a five-carbon polyol (e.g., ribitol, arabitol, or xylitol),iso-erythritol, maltitol, and saccharine. Methods for making and using, as well as kits comprising the disclosed compositions, are also provided.

An object of the present invention is to provide novel methods for forming glucosyl-transferred polyalcohols, glucosyl-transferred glucuronic acid, and glucosyl-transferred derivatives of glucose whose C-6 hydroxyl group bound to a saccharide by using an enzymatic reaction. The present invention solves the above object by providing a method for transferring a glucosyl residue to polyalcohols, glucuronic acid and / or derivatives of glucose whose C-6 hydroxyl group bound to a saccharide, comprising a step of: allowing a trehalose phosphorylase to act on a saccharide containing glucose as a component sugar and one or more polyalcohols selected from the group consisting of inositol, ribitol, erythritol, and glycerol; glucuronic acid and / or a salt thereof; and / or one or more derivatives of glucose whose C-6 hydroxyl group bound to a saccharide selected from the group consisting of isomaltose, gentiobiose, melibiose, isomaltotriose, and isopanose.

L-Ribose is produced by the steps of producing ribitol from a saccharide raw material by using a microorganism having an ability to produce ribitol from a saccharide raw material, producing L-ribulose from the ribitol by using a microorganism having an ability to produce L-ribulose from ribitol, and producing L-ribose from the L-ribulose by using a microorganism having an ability to produce L-ribose from L-ribulose.

Chemical mechanical planarization (CMP) polishing compositions, methods and systems are provided to reduce oxide trench dishing and improve over-polishing window stability. High and tunable silicon oxide removal rates, low silicon nitride removal rates, and tunable SiO2: SiN selectivity are also provided. The compositions use unique chemical additives, such as maltitol, lactitol, maltotritol, ribitol, D-sorbitol, mannitol, dulcitol, iditol, D-(−)-Fructose, sorbitan, sucrose, ribose, Inositol, glucose, D-arabinose, L-arabinose, D-mannose, L-mannose, meso-erythritol, beta-lactose, arabinose, or combinations thereof as oxide trench dishing reducing additives.

The invention discloses a planting method for improving the yield of drought lotus root. The planting method includes: seed selection and breeding, selecting underground tubers of drought lotus, soaking the tubers in a dandelion exaction solution, and performing tissue culture to acquire drought lotus root tissue culture seedlings; land selection; soil preparation and planting; field management, performing hill up on roots of the seedlings twice after planting; water and fertilizer management, applying water fertilizer to the roots of the drought lotus, wherein the water fertilizer includes: urea, ammonium bicarbonate, potassium chloride, ammonium phosphate, potassium nitrate, calcium nitrate, magnesium sulfate, zinc chloride, sodium molybdate, ammonium molybdate, boric acid, salicylic acid, Pterocypsela indica, Cortex dictamni, Gnaphalium affine, Rheum palmatum, Rosa laevigata, Ginkgobiloba, Prunella vulgaris, Scutellaria barbata, liquor, arabitol, ribitol, dulcitol, glycerol, fatty methyl estersulfonates and water; and disease and pest control. The planting method can effectively improve the yield of drought lotus roots, and has high practical application value.

The invention provides methods and compositions for the production of L-ribitol and other rare sugars using a mannitol-1-dehydrogenase or a polyol-1-dehydrogenase.

The invention discloses a method for catalytic synthesis of a conjugated gamma-linolenic acid isomer by virtue of a surfactant-coated bacterium, wherein the method comprises the following steps (1) re-suspending each gram of lactobacillus casei CGMCC 1.574 bacterium in 5ml of a permeabilization treatment solution, treating at 37 DEG C for 20min, centrifuging and collecting a permeabilized bacterium; (2) washing the permeabilized bacterium with 60mM of a phosphate buffer solution which is at 5.8 in pH value; centrifuging and collecting the bacterium; re-suspending each gram of the wet bacterium in 20mL of the 60mM of phosphate buffer solution which is at 5.8 in pH value, dropping an acetone solution which contains 1% of dioleyl glutamate ribitol and uniformly mixing at the same time; processing at 4-40 DEG C for 2-6h, centrifuging and collecting the bacterium, and freeze-drying so as to obtain a coated bacterium; (3) adding each gram of the freeze-dried coated bacterium to 500ml of normal hexane, uniformly stirring, adding 0.1-0.3% of gamma-linolenic acid in terms of the volume percentage of the normal hexane and reacting at 4-40 DEG C for 1-12h; and (4) centrifuging and isolating the coated bacterium and recovering the normal hexane, so as to obtain a finished product, namely c6,c9,t11-conjugated gamma-linolenic acid isomer. The method disclosed by the invention is short in reaction time; the coated bacterium can be recycled for several times, so that yield is significantly improved; and the method is free from environmental pollution and is capable of remarkably reducing production cost.

The present disclosure describes compositions comprising substantially pure ribitol, pharmaceutical compositions of ribitol, and methods of making ribitol. The methods may include combining a reducing agent (e.g., borohydride) and ribose (e.g. D-ribose), optionally with stirring, to form a first reaction mixture; and contacting the first reaction mixture and an acidic quenching agent, optionally with stirring, to form a second reaction mixture, thereby forming ribitol.

The present invention provides a stable synthetic saccharide of Hib polyribosylribitol-phosphate (PRP) derivative and conjugate thereof. Said saccharide, said conjugate and pharmaceutical compositions thereof are hydrolysis-resistant, long-term stable and useful for the prevention and / or treatment of diseases associated with Haemophilus influenzae, and more specifically of diseases associated with Haemophilus influenzae type b, preferably diseases selected from meningitis, pneumonia, and epiglotitis. They have general formula (I): wherein A is formula (II) or formula (III); B is formula (IV); C is formula (V); D is formula (VI); E is formula (VII); F is formula (VIII) or formula (IX).