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47 results about "Teichoic acid" patented technology
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Teichoic acids (cf. Greek τεῖχος, teīkhos, "wall", to be specific a fortification wall, as opposed to τοῖχος, toīkhos, a regular wall) are bacterial copolymers of glycerol phosphate or ribitol phosphate and carbohydrates linked via phosphodiester bonds.
Antitumor and anticholesterol preparations containing a lipoteichoic acid from streptococcus
InactiveUS6214978B1Improve usabilityImprove liquidityBacteriaPeptide/protein ingredientsBackbone chainHyaluronidase
The invention concerns a new lipoteichoic acid which can be isolated from the new Streptococcus sp DSM 8747. The new LTA is called LTA-T. It has a lipid anchor, which is a galacto-furanosyl-beta-1-3-glycerol with different rests of fatty acids esterified in the two adjacent hydroxy groups in the glycerol moiety and a non-glycosylated, linear, unbranched GroP chain with an unusual short hydrophilic GroP chain. The hydrophilic backbone consists of only 10 glycerophosphate units esterified with D-alanine in an extent of 30%. The invention further concerns a pharmaceutical composition with the new LTA-T, optionally together with a monokine and / or hyaluronidase, a method of treating cancer comprising administration of an antitumor effective amount thereof, a method of producing the new compound and the new pharmaceutical composition, two degradation products of the new LTA-T and their use, and the new Streptococcus strain from which the new compound can be isolated.
Owner:LUNAMED
Opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria
InactiveUS20080019976A1Enhance phagocytosis and killing of the bacteriaHigh degree of sequence homologyAntibacterial agentsPeptide/protein ingredientsHuman sequenceLipoteichoic acid binding
The present invention encompasses monoclonal antibodies that bind to lipoteichoic acid (LTA) of Gram positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and killing of the bacteria in vitro. The invention also provides antibodies having human sequences (chimeric, humanized and human antibodies). The invention also sets forth the variable regions of three antibodies within the invention and presents the striking homology between them.
Owner:BIOSYNEXUS INC
Production process of soy sauce flavor type soybean sauce
InactiveCN104256507AImprove sauce flavorEnhance immune functionFood preparationAnaphylaxisAdditive ingredient
The invention provides a production process of a soy sauce flavor type soybean sauce. The soy sauce flavor type soybean sauce is prepared by using vinasse as a raw material, and aspergillus oryzae strains and bifidobacterium strains as strains. The production process is characterized in that with vinasse as the raw material, the production cost is reduced; and meanwhile, with bifidobacterium as a fermenting strain, the prepared soybean sauce contains nutritional ingredients such as lipoteichoic acid, membrane teichoic acid and peptidoglycan, so that the soybean sauce is endowed with a unique flavor, and the soybean sauce has the efficacies of enhancing the immunologic function and anti-tumour effect of the organism, relieving and removing fatigue, adjusting balance of intestinal microflora and improving the liver function, has nutritional benefits, and also has the efficacies of relieving uremia, resisting anaphylaxis, increasing the appetite, reducing blood pressure and blood cholesterol, preventing arteriosclerosis and the like, so as to promote health of a human body. The soybean sauce prepared by the production process is dark in color, and thick in juice, contains sugar but is not sweet, contains salt but is not salty, contains acid but is not sour, and has the unique thick soy sauce flavor.
Owner:仁怀市城关酱醋厂
Compositions For Reducing Bacterial Carriage And Cnc Invasion And Methods Of Using Same
ActiveUS20070286866A1Reduce and prevent bacterial infectionAntibacterial agentsSenses disorderAntigenNasal cavity
Owner:UAB RES FOUND
Preparation method of functional lactobacillus acidophilus peptidoglycan and anti-inflammatory activity use of functional lactobacillus acidophilus peptidoglycan
ActiveCN103981232AReduce inflammationOrganic active ingredientsAntipyreticLactobacillus acidophilusTeichoic acid
The invention discloses a preparation method of a functional lactobacillus acidophilus peptidoglycan and an anti-inflammatory activity use of the functional lactobacillus acidophilus peptidoglycan. The preparation method comprises the following steps of inoculating a MRS culture medium with lactobacillus acidophilus having an accession number of CGMCC No. 8920 according to an inoculation ratio of 2.0-4.0% by volume, carrying out anaerobic cultivation at a temperature of 37 DEG C for 18-24h, carrying out centrifugation under a centrifugation force of 4000-8000g for 15-20min so that a fermentation broth is removed, adding 4wt% of a SDS solution into the precipitated acidophilus peptidoglycan, carrying out high-temperature pyrolysis at a temperature of 100 DEG C for 30min to remove a protein component, adding 10wt% of a trichloroacetic acid solution into the precipitates to remove teichoic acid, carrying out overnight dialysis desalination on the precipitates at a temperature of 4 DEG C, carrying out pre-refrigeration on the precipitates at a temperature of -80 DEG C for 6h, fast putting the refrigerated precipitates into a drying device, and carrying out drying treatment under the pressure of 80-120Pa for 24h to obtain a powdery product. The functional lactobacillus acidophilus peptidoglycan has good inhibition and conditioning effects on LPS-caused inflammation.
Owner:厦门赋源康实业有限公司
Medical antibacterial wound-protecting hydrogel dressing and preparation method thereof
The invention discloses an antibacterial wound-protecting hydrogel dressing and a preparation method thereof. The antibacterial wound-protecting hydrogel dressing comprises the following main components: a water-soluble chitosan derivative, matrix glue and a water-soluble high-molecular polymer. The preparation method comprises the following steps: preparing a chitosan derivative from purified water, fully and uniformly mixing the components, adding the chitosan derivative into a mold, adding a liquid matrix gel and an acrylamide solution, sequentially adding a crosslinking agent, an initiatorand an accelerator to form gel, and rinsing the gel with deionized water to remove the redundant crosslinking agent, thereby obtaining the hydrogel dressing. The dressing can absorb wound exudate andsecreta. The chitosan derivative has polycation, so that when being combined with negatively charged protein, teichoic acid and the like on the surface of thallus, the chitosan has strong antibacterial activity, and has unique advantages in prevention and treatment of wound infection. Matrix glue is one of extracellular matrixes, contains various bioactive components and plays an important role in the wound healing process. The hydrogel dressing can be applied to protection and repair of various types of wounds such as burns, wounds, pressure sores and the like.
Owner:XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
Method for extracting whole peptidoglycan from bifidobacterium longum NQ-1501
ActiveCN102321187AComplete structureGood anti-tumor effectPeptide/protein ingredientsBacteria material medical ingredientsCentrifugationFreeze-drying
The invention relates to a method for extracting whole peptidoglycan from bifidobacterium longum NQ-1501. The method comprises the following steps of removing fat-like substances on a cell membrane through a degreasing process, extracting teichoic acid to improve cell membrane permeability, removing protein-like substances in cells through an enzymolysis solution, carrying out centrifugation cleaning to remove impurities, and carrying out freeze-drying to obtain whole peptidoglycan. The whole peptidoglycan extracted by the method has a complete cell wall structure and has good antitumor effects. The method has the advantages of strong practicality, simple operation, short period, simple and reasonable processes, low cost, high yield, and good adaptability for large-scale production. The invention also relates to whole peptidoglycan prepared by the method and a medicinal preparation prepared from the whole peptidoglycan.
Owner:内蒙古双奇药业股份有限公司
Integrated peptidoglycan and preparation method thereof
ActiveCN101717806AGood anti-tumor effectPracticalPeptidesFermentationMembrane permeabilityFreeze-drying
The invention discloses a integrated peptidoglycan which can suppress tumor growth effectively and can be widely used in antitumor drugs due to the integrated spatial structure of the peptidoglycan extracted. The invention further discloses a method for extracting the integrated peptidoglycan, which comprises the following steps of: extracting teichoic acid to enhance membrane permeability, degreasing to remove fatty substances on the cell membranes, removing protein substances in the cells through an enzymatic solution, and finally centrifuging and cleaning to remove impurities and freeze-drying to obtain the whole peptidoglycan. The invention has the advantages that the cell wall has a whole structure since the integrated peptidoglycan is extracted, thereby having excellent antitumor effect. The preparation method has the advantages of strong practicability, simple operation, short period, simple and reasonable steps, low cost and high yield, and is suitable for large-scale production.
Owner:内蒙古双奇药业股份有限公司
Soil heavy metal treating agent and application thereof
ActiveCN105921509AReduce contentSimple structureBacteriaContaminated soil reclamationSoil heavy metalsMontmorillonite
The invention relates to a soil heavy metal treating agent and an application thereof. The soil heavy metal treating agent consists of bacillus subtilis fermentation liquor, montmorillonite, furfural residues, gypsum powder and humic acid. According to the soil heavy metal treating agent, by virtue of special fermentation culture on bacillus subtilis, cell walls of the bacillus subtilis contain rich teichoic acid and peptidoglycan. Moreover, the montmorillonite, the furfural residues, the gypsum powder and the humic acid are combined, so that heavy metals in the soil can be quickly and efficiently reduced by the soil heavy metal treating agent.
Owner:SHANDONG AGRI UNIV FERTILIZER TECH CO LTD
Soy sauce flavor type vinegar making process
ActiveCN104212697ALow costReduced alcoholic fermentation stepsMicroorganism based processesVinegar preparationNutritionCholesterol
The invention provides a soy sauce flavor type vinegar making process. Distillers' grains are utilized as the raw material to make the soy sauce flavor type vinegar, so that raw material cost is reduced, meanwhile a raw material alcoholic fermentation step is reduced, and the made vinegar has soy sauce flavor. Acetic acid strain and bifidobacterium strain are utilized as the vinegar making fermentation strain, and the made vinegar contains nutrient contents such as lactic acid, acetic acid, multivitamin, lipoteichoic acid, teichoic acid and peptidoglycan by means of control of temperature, oxygen and the like of all fermentation periods. The vinegar not only has the specific flavor of itself but also achieves the effects of enhancing the immunity of a human body, restraining cancer, remitting and removing fatigue, adjusting the balance of enteric microbial flora, improving the liver function, improving the nutrition effect, remitting the uremia, resisting allergy, increasing appetite, reducing blood pressure and cholesterol in blood, preventing arteriosclerosis and the like, so that the vinegar can further promote human body health, enhances national physical health and has good social and economical benefits. Therefore, the bifidobacterium vinegar is the modern novel healthcare vinegar which can enhance human body health and is cheap and fine.
Owner:山东菏泽巧媳妇食品有限公司
Compositions for reducing bacterial carriage and CNS invasion and methods of using same
Provided herein are compositions designed to reduce or prevent bacterial infections (for example pneuomococcal infections), nasal carriage, nasal colonization, and central nervous system invasion. Provided herein is a composition comprising a pneumococcal neuraminidase, phosphocholine, pneumococcal teichoic acid, pneumococcal lipoteichoic acid, or an antigenic portion of either neuraminidase, phosphocholine, pneumococcal teichoic acid, pneumococcal lipoteichoic acid. Optionally, the composition can comprise any combination of a pneumococcal neuraminidase, a phosphocholine, a pneumococcal teichoic acid, a pneumococcal lipoteichoic acid or an antigenic portion of any one of these. Optionally the agents are detoxified. Further provided are methods of making and using the compositions disclosed herein. Specifically provided are methods of generating antibodies in a subject comprising administering to the subject an agent or composition taught herein. Also provided are methods of reducing or preventing nasal carriage or pneumococcal infection in a subject comprising administering to the subject a composition taught herein.
Owner:UAB RES FOUND
Rifamycin analogs and antibody-drug conjugates thereof
ActiveUS20200368361A1Antibacterial agentsOrganic active ingredientsInfectious DisorderAntiendomysial antibodies
The disclosure relates to rifamycin analog compounds, intermediates and precursors thereof, and pharmaceutical compositions capable of inhibiting bacterial growth (e.g., S. aureus growth) and treating bacterial infections (e.g., S. aureus infections). The disclosure further relates to antibody-drug conjugates of rifamycin analog compounds and antibodies, for example, antibodies specific for infectious disease-related targets such as membrane glycoprotein receptor (MSR1), wall teichoic acids (WTA) or Protein A, and methods of use thereof to inhibit bacterial growth and treat bacterial infections.
Owner:REGENERON PHARM INC
Method for culturing streptococcus penumoniae rich in teichoic acid
ActiveCN102093963APromote growthHigh content of teichoic acidBacteriaMicroorganism based processesC polysaccharideStreptococcus mitis
The invention relates to a method for culturing streptococcus penumoniae rich in teichoic acid, which is characterized in that choline chloride is added in a liquid culture medium, the culture process is optimized, and the obtained streptococcus penumoniae thallus is rich in teichoic acid and is especially suitable to serve as material for extracting streptococcus penumoniae C polysaccharide.
Owner:LANZHOU INST OF BIOLOGICAL PROD
Composition for preventing or treating staphylococcus aureus infection
The present invention relates to: a composition containing, as an active ingredient, wall teichoic acid (WTA)-attached peptidoglycan (PGN); a method for preventing or treating Staphylococcus aureus infection by using the composition; and a method for preparing soluble wall teichoic acid-attached peptidoglycan (WTA-PGN), which can be used as an active ingredient in the composition. The composition of the present invention can be utilized for the prevention or treatment of Staphylococcus aureus infection by: opsonophagocytosis caused by an antigen-antibody reaction; and neutrophil-mediated phagocytosis caused by T cell activation during the early stage of infection.
Owner:GREEN CROSS CORP THE +1
Polyamine derivative medicinal salt and its preparation method and use
ActiveCN105348137AImprove survival rateEasy to manufactureAntibacterial agentsOrganic active ingredientsMedicinal chemistryVirus
The invention relates to a polyamine derivative medicinal salt and its preparation method and use in preparation of a drug for treating pyemia. The novel compound has good antagonistic action on a plurality of pyemia-causing pathogen-related molecules such as bacterial lipopolysaccharide (endotoxin), bacterial genome DNA, peptidoglycan, teichoic acid, virus RNA and zymosan, and can be used for preparation of a drug for treating pyemia.
Owner:GRAND PHARM (CHINA) CO LTD
Opsonic and protective antibodies specific for lipoteichoic acid of gram positive bacteria
Owner:BIOSYNEXUS INC
Method for separating and refining isobomyl acetate
ActiveCN102329230AOvercome the shortcomings of high energy consumption and low product yield in batch separationHigh yieldOrganic compound preparationCarboxylic acid esters preparationAcid waterPtru catalyst
The invention relates to a method for separating and refining isobomyl acetate. The method is characterized in that: an acetic acid solution containing water is produced on the top of a crude ester rectification tower; a mixture of camphene and acetic acid is mainly obtained through side take-off; a crude product of the isobomyl acetate is produced from the tower; and the crude product enters a refined ester evaporator, is whitened and then enters a refined ester vapor-liquid separation tank for separation so as to obtain high-purity isobomyl acetate. The disadvantages of high energy consumption of batch separation, low product yield and the like existing in the prior art are overcome; acid water is produced from the top of the crude ester rectification tower, crude ester is produced fromthe tower, the clear segmentation is realized by using a single tower, teichoic acid is produced from one side and only contains the acetic acid and the camphene, and when the teichoic acid is used for the circular reaction, the selectivity of the reaction is improved and the service life of a catalyst is prolonged, so the process is advanced and the energy consumption is low; and the method has the advantages of continuous production, compact flow, low energy consumption and the like, and the product is high in yield and has stable quality.
Owner:福建南平青松化工有限公司
Postbiotics as well as preparation method and application thereof
PendingCN114480192AGood thermal stabilityGood pH toleranceBacteriaLactobacillusMetaboliteDietary supplement
The invention relates to a metagen and a preparation method and application thereof, the metagen comprises inactivated lactobacillus plantarum LP220 and a fermentation metabolite thereof, and the preservation number of the lactobacillus plantarum LP220 is CCTCC (China Center For Type Culture Collection) NO: M2018465. The metagen comprises the following components: lactobacillus plantarum LP220 greater than or equal to 1 * 10 < 11 > CFU / g, lipoteichoic acid greater than or equal to 35 ng / kg, short-chain fatty acid greater than or equal to 90 [mu] g / g, polypeptide content greater than or equal to 6%, and molecular weight 1t; 1000DA small molecule peptide accounts for more than 80% of the total peptide content, and the organic acid content is more than or equal to 100mg / g. The invention further discloses a preparation method of the postbiotics and application of the postbiotics in preparation of dietary supplements, health care products, medicines, foods or solid beverages for enhancing immunity. The metagen contains lactobacillus plantarum thalli above 1 * 10 < 11 > CFU / g, is rich in functional components such as small molecule peptides, short-chain fatty acids, organic acids, amino acids and the like, and improves and regulates the organ index, cellular immune function and NK cell activity of a body to remarkably enhance the immune function of the body.
Owner:SICHUAN GAOFUJI BIOLOGICAL TECH
Lipoteichoic acid enzyme-linked immunosorbent assay (ELISA) detection kit and preparative technique thereof
The invention relates to preparation of lipoteichoic acid monoclonal antibodies and an e-linked immunosorbent assay (ELISA) detection kit manufactured by using the preparation. An ELISA detection reagent is a high-technology product in the field of biological medicines, and is an in-vitro diagnostic reagent. Following a search, the ELISA detection reagent fills the domestic blank, the current situation of detecting staphylococcus aureus by using a time-wasting and labor-wasting blood culture method is changed, an enzyme linked immunosorbent assay which is high in sensitivity and specificity is adopted, and detection time is shortened. Balb / c female mice are immuned by lipoteichoic acid antigens extracted from cell walls of the staphylococcus aureus, then monoclonal antibodies L are obtained and are IgG immune globulin after being detected, and the valence of the antibodies is 1*106. The monoclonal antibodies are purified by a saturated ammonium sulfate precipitation and affinity chromatography technology. Lipoteichoic acids serve as coating antigens, the obtained monoclonal antibodies serve as enzyme-labeled antibodies, and then a competition-method ELISA kit is manufactured and is used for diagnosing staphylococcus aureus infection which serves as one of references for clinical diagnosis.
Owner:TIANJIN LANRY BIO TECH
Shampoo for treating seborrheic dermatitis
ActiveCN110812268APromote secretionReduce inflammationCosmetic preparationsHair cosmeticsFlaxseed extractPhosphorylation
The invention provides a shampoo for treating seborrheic dermatitis, and belongs to the technical field of daily chemical products. The shampoo comprises a shampoo composition comprising a common bombax flower extract, a tea oil cake extract, monohydroxyethyl rutin and L-cysteic acid, a flaxseed extract and rice extract. The invention also provides a shampoo for repairing scalp damage and a methodof using the same. The shampoo for treating seborrheic dermatitis can promote staphylococcus epidermidis to secrete lipoteichoic acid, inhibiting phosphorylation induction of malassezia furfur to P65protein in the keratinocyte NF-kB pathways; the expression of partial glyceride lipase of malassezia globosa is inhibited to suppress the growth of the malassezia globosa, thereby alleviating the inflammatory response of the scalp and improving the treatment effect on the scalp seborrheic dermatitis.
Owner:百草堂(湖北)制药有限公司
Lactobacillus acidophilus surface layer protein A (SlpA) as a therapeutic agent for the treatment of inflammatory diseases
Owner:UNIV OF FLORIDA RES FOUNDATION INC
Composition for preventing or treating staphylococcus aureus infection
A composition containing wall teichoic acid-attached peptidoglycan (WTA-PGN) as an active ingredient, a method for preventing or treating Staphylococcus aureus infectious diseases using the composition, and a method for preparing a soluble WTA-PGN which can be used as an active ingredient in the composition are provided. The composition of the present invention can be effectively used for preventing or treating Staphylococcus aureus infectious diseases by opsonophagocytosis due to antigen-antibody reaction and neutrophil-mediated phagocytosis due to T cell activation at the early stage of infection.
Owner:THE GREEN CROSS CORP +1
A kind of production technology of sauce-flavor vinegar
ActiveCN104212697BLow costReduced alcoholic fermentation stepsMicroorganism based processesVinegar preparationCholesterolAllergy
The invention provides a soy sauce flavor type vinegar making process. Distillers' grains are utilized as the raw material to make the soy sauce flavor type vinegar, so that raw material cost is reduced, meanwhile a raw material alcoholic fermentation step is reduced, and the made vinegar has soy sauce flavor. Acetic acid strain and bifidobacterium strain are utilized as the vinegar making fermentation strain, and the made vinegar contains nutrient contents such as lactic acid, acetic acid, multivitamin, lipoteichoic acid, teichoic acid and peptidoglycan by means of control of temperature, oxygen and the like of all fermentation periods. The vinegar not only has the specific flavor of itself but also achieves the effects of enhancing the immunity of a human body, restraining cancer, remitting and removing fatigue, adjusting the balance of enteric microbial flora, improving the liver function, improving the nutrition effect, remitting the uremia, resisting allergy, increasing appetite, reducing blood pressure and cholesterol in blood, preventing arteriosclerosis and the like, so that the vinegar can further promote human body health, enhances national physical health and has good social and economical benefits. Therefore, the bifidobacterium vinegar is the modern novel healthcare vinegar which can enhance human body health and is cheap and fine.
Owner:山东菏泽巧媳妇食品有限公司
Lactobacillus plantarum lipoteichoic acid and application thereof in inhibition of amyloid protein aggregation
PendingCN114099555AImprove securityInhibit aggregationNervous disorderUnknown materialsProtein aggregationGlycerol
The invention provides lactobacillus plantarum lipoteichoic acid and application of the lactobacillus plantarum lipoteichoic acid in inhibition of amyloid protein aggregation. The main chain of the lactobacillus plantarum lipoteichoic acid contains glycerol, and the side chain of the lactobacillus plantarum lipoteichoic acid contains a large amount of N-acetyl glucosamine and alanine modification. The lipoteichoic acid can effectively inhibit aggregation of beta-amyloid protein 1-42 (Abeta42), is a potential Abeta42 aggregation inhibitor, and can be applied to development of drugs, health care products or functional food for preventing and / or improving Alzheimer's disease.
Owner:TIANJIN UNIV OF SCI & TECH
Lipoteichoic acid from lactic acid bacteria and its use to modulate immune responses mediated by gram-negative, potentially pathogenic gram-positive bacteria
InactiveCN100502888CReduce inflammationEnhances protective immune processesAntibacterial agentsCosmetic preparationsBiotechnologyInflammation Process
The present invention relates to a composition for modulating immune responses induced by Gram-negative bacteria, potentially pathogenic Gram-positive bacteria and / or their derivatives, said composition comprising a lipophosphowall from lactic acid bacteria Acid as active ingredient. The present invention also relates to lipoteichoic acid from lactic acid bacteria and / or the lactic acid bacteria producing it and / or their culture supernatants as active ingredients in the preparation of pharmaceutical, oral or topical products for cosmetic, dermatological or eye applications. , for use in food or pet food to modulate bacterial colonization, immune responses, and reduce inflammatory processes associated with bacterially mediated diseases and infections in the gastrointestinal tract, bone, skin, eyes, ears, lungs, and oral cavity. The present invention also relates to specific lipoteichoic acids.
Owner:SOC DES PROD NESTLE SA
Streptococcus uberis extract as an immunogenic agent
ActiveUS20190038736A1Antibacterial agentsBacterial antigen ingredientsMicrobiologyStreptococcus uberis
The present invention relates to an extract of Streptococcus uberis as an immunogenic agent. It also relates to a process for obtaining said agent which comprises incubating a biofilm-producing S. uberis strain to obtain a biofilm and thermally treating the biofilm obtained. It relates also to a pharmaceutical composition comprising teichoic acids, preferably lipoteichoic acids, for use in the prevention and / or treatment of mastitis and / or infections caused by Streptococcus sp. or by biofilm-producing bacteria. The present invention also relates to a vaccine which comprises said immunogenic agent and to said vaccine and immunogenic agent for use in the prevention and / or treatment of infections caused by Streptococcus sp., especially in the prevention and / or treatment of mastitis caused by S. uberis. It also relates to a vaccination kit which comprises said agent or vaccine.
Owner:HIDRA SCI S L U
Preparation process of agricultural peptidoglycan derived from waste thalli
The invention discloses a preparation process of peptidoglycan derived from waste thalli dregs. The preparation process comprises the following steps: culturing seeds by virtue of Nipoisson bacteria,inoculating the seeds into glutamic acid waste liquid with relatively high salt content, obtaining thalli after fermentation is finished, and carrying out superfine grinding on the thalli to remove teichoic acid and protein. The production process does not need special equipment, is low in energy consumption and simple in process flow, and is an agricultural peptidoglycan preparation process whichis easy to industrialize and has good economic benefits.
Owner:JINAN HANGCHEN BIOTECHNOLOGY CO LTD +2
Method for extracting peptidoglycan from lactobacillus
The invention relates to a method for extracting peptidoglycan from Lactobacillus helveticus MB2-1. The method is characterized in that the permeability of cell walls is increased by physical and chemical methods, the physical method adopts an ultrasonic crushing method, and the chemical method adopts a trichloroacetic acid method to extract teichoic acid so as to increase the permeability of cell membranes. Fat substances on cell membranes are removed through degreasing of an organic reagent, protein substances in cells are removed through composite enzymatic hydrolysate, finally, impurities are removed through centrifugal cleaning, and freeze-drying is conducted to obtain peptidoglycan. The preparation method has the advantages that the extracted complete peptidoglycan with the probiotic effect is high in practicability, simple to operate, short in period, simple, convenient and reasonable in step, low in cost, high in yield and suitable for large-scale production.
Owner:NANJING AGRICULTURAL UNIVERSITY
Method for culturing streptococcus penumoniae rich in teichoic acid
ActiveCN102093963BPromote growthHigh content of teichoic acidBacteriaMicroorganism based processesC polysaccharideStreptococcus mitis
The invention relates to a method for culturing streptococcus penumoniae rich in teichoic acid, which is characterized in that choline chloride is added in a liquid culture medium, the culture process is optimized, and the obtained streptococcus penumoniae thallus is rich in teichoic acid and is especially suitable to serve as material for extracting streptococcus penumoniae C polysaccharide.
Owner:LANZHOU INST OF BIOLOGICAL PROD
Compositions for dental treatment comprising lipoteichoic acids or parts thereof like mono- or polyglycerphosphates
InactiveUS20130078194A1Cosmetic preparationsOrganic active ingredientsOral bacterial infectionToothpaste
The present invention refers to compositions for the treatment or prophylaxis of infectious or inflammatory processes in the oral cavity (cavitas oris) including dental hygiene, the composition comprising lipoteichoic acids and glycerophosphate derivatives, preferably added into a dental hygiene product like toothpastes, toothgels, creams or rinsing fluids, the use of glycerophosphate derivatives as prophylaxis against bacterial infections of the oral cavity like dental caries, or the use of polyglycerophosphates for the production of a medicament for the treatment of or prophylaxis against bacterial infections of the oral cavity, like dental caries.
Owner:LUNAMED
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