The present invention features outer membrane vesicles (OMVs), such as native or detergent extracted OMVs from N. gonorrhoeae. For example, the compositions may include OMVs obtained from two or more different gonococcal strains, or OMVs containing different outer membrane proteins and / or lipooligosaccharides (LOS). The invention also provides for genetically modified gonococci as well as immunogenic compositions containing the outer membrane vesicles.