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42 results about "Meningioma" patented technology

A condition in which a (usually) non-cancerous tumor develops from the membrane that surround the brain and spinal cord.

Central nervous system administration of medications by means of pelvic venous catheterization and reversal of Batson's Plexus

InactiveUS20050070843A1Effective pain managementFocusNervous disorderSurgeryVenous vesselVenous blood
An infusor system for administering medications to a venous blood vessel in the body of a patient. The infusor system includes a flexible, elongated delivery tube having opposite ends. One of the ends is couplable to a supply of liquid medication, which is remote from the venous blood vessel. The system further includes a delivery component coupled to the other end of the delivery tube. This delivery component is adaptable to be placed in confronting relationship with the venous blood vessel so that medication from said supply may be introduced directly into the venous blood vessel and distributed in the body of the patient. The infusor system further includes a pressure-altering device used for increasing intraabdominal pressure in the body of the patient. Sampling of venous blood from the meningorrhachidian vasculature is also possible.
Owner:SERENE MEDICAL

Method of diagnosing and treating gliomas

The present invention provides a recombinant toxin and monoclonal antibody which specifically binds to glial-derived or meningioma-derived tumor cells. Also provided are various methods of screening for malignant gliomas and meningiomas. Further provided are methods of treating malignant gliomas, including glioblastoma multiforme and astrocytomas.
Owner:UAB RES FOUND

Diagnosis and treatment of neuroectodermal tumors

The present invention provides fusion proteins for the detection and treatment of neuroectodermal tumors. Previous work demonstrated that chlorotoxin is specific for glial-derived or meningioma-derived tumor cells. The current invention has extended the use of chlorotoxin-cytotoxin fusion proteins to treat the whole class neuroectodermal tumors such as gliomas, meningiomas, ependymonas, medulloblastomas, neuroblastomas, gangliomas, pheochromocytomas, melanomas, PPNET's, small cell carcinoma of the lung, Ewing's sarcoma, and metastatic tumors in the brain. Also, diagnostic methods are provided for screening neoplastic neuroectodermal tumors.
Owner:TRANSMOLECULAR INC

Meningioma rapid segmentation qualitative method based on deep neural network

The invention relates to the field of meningioma level judgment before an operation, and discloses a meningioma rapid segmentation qualitative method based on a deep neural network, and the method comprises the following steps: preparing a magnetic resonance brain image; establishing a meningioma segmentation model, and screening out an effective image containing a meningioma region from the magnetic resonance brain image through the meningioma segmentation model; and establishing a meningioma grading model, carrying out grading detection on the effective image through the meningioma grading model, and outputting a meningioma grading detection result. By means of the method, only a series of magnetic resonance brain images generated after scanning of a certain patient need to be input intothe network, the grading result of meningioma of the patient is rapidly given after comprehensive analysis and calculation of all the magnetic resonance brain images, the purpose of assisting a doctor in diagnosis is achieved, the whole process is automatically conducted, a large amount of repeated work of doctors is reduced, time is saved, and a patient can be treated more quickly.
Owner:SICHUAN UNIV

Treatment of meningiomas using phenylbenzothiazole, stilbene, biphenylalkyne, or pyridine derivatives

A method and composition for treating a meningioma in a subject are disclosed. The method includes the step of administering to the subject a therapeutically effective amount of a composition including a cytotoxic agent associated with a phenylbenzothiazole derivative or a stilbene derivative or a biphenylalkyne derivative that accumulates within meningiomas. In one version of the method, the phenylbenzothiazole derivative is a compound of formula (V).
Owner:MAYO FOUND FOR MEDICAL EDUCATION & RES

Fully-automatic pelvic tumor segmentation method and system, storage medium and terminal

The invention provides a full-automatic pelvic tumor segmentation method and system, a storage medium and a terminal thereof, comprising the following steps: preprocessing and data amplification are carried out on images in a meningioma image set to obtain meningioma training data; training U-net convolutional neural network based on the meningioma training data; the pelvic tumor training data were obtained by preprocessing and data amplification of the pelvic tumor images with tumor boundary gold standard drawn in the pelvic tumor image set. Training data of the pelvic tumor based on the training results of the U-net to realize fine-tuning of the full convolution neural network to get the optimal U-net fully convolution neural networks; inputting the acquired pelvic tumor image into the optimal U-Net total convolution neural network to obtain the segmentation results of pelvic tumors. The invention discloses a full-automatic pelvic tumor segmentation method and system, a storage medium and a terminal through migration learning U-net fully convolutional neural network to realize automatic pelvic tumor segmentation, which greatly improves the efficiency of medical interaction and the accuracy of pelvic tumor segmentation.
Owner:SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE

Somatostatin agonists

The present invention is directed to cyclic peptides of formula (I): X-A1-cyclo(D-Cys-A3-A4-Lys-A6-A7)-A8-Y, or a pharmaceutically acceptable salt thereof. The peptides bind selectively to the somatostatin subtype receptor type-5 and elicit an agonist effect from the somatostatin subtype receptors. The peptides are useful for treating a variety of diseases, including Cushings Syndrome, gonadotropinoma, hyperparathyroidism, Paget's disease, VIPoma, nesidioblastosis, hyperinsulinism, gastrinoma, Zollinger-Ellison Syndrome, hypersecretory diarrhea related to AIDS and other conditions, irritable bowel syndrome, pancreatitis, Crohn's Disease, systemic sclerosis, thyroid cancer, psoriasis, hypotension, panic attacks, sclerodoma, small bowel obstruction, gastroesophageal reflux, duodenogastric reflux, Graves' Disease, polycystic ovary disease, upper gastrointestinal bleeding, pancreatic pseudocysts, pancreatic ascites, leukemia, meningioma, cancer cachexia, acromegaly, restenosis, hepatoma, lung cancer, melanoma, inhibiting the accelerated growth of a solid tumor, decreasing body weight, treating insulin resistance, Syndrome X, prolonging the survival of pancreatic cells, fibrosis, hyperlipidemia, hyperamylinemia, hyperprolactinemia and prolactinemia.
Owner:SOC DE CONSEILS DE RECH

Imaging of meningiomas using phingylbenzothiazole, stilbene, or biphenylalkyne derivatives

Methods for detecting or ruling out a meningioma in a patient using a phenylbenzothiazole derivative or a stilbene derivative or a biphenylalkyne derivative, and a medical imaging technique such as positron emission tomography / computed tomography are disclosed. In one version of the method, the phenylbenzothiazole derivative is a compound of formula (V):
Owner:MAYO FOUND FOR MEDICAL EDUCATION & RES

Oncolytic cancer immunotherapies and methods of use

Disclosed herein are methods of treating a brain cancer comprising administering to a subject in need thereof a viral composition comprising a flavivirus or portion of a flavivirus wherein the flavivirus is engineered to comprise a heterologous nucleic acid sequence encoding a suicide gene. In some embodiments, the brain cancer is selected from the group consisting of astrocytoma, oligodendroglioma, ependymoma, meningioma, schwannoma, craniopharyngioma, germinoma, and pineocytoma. In some embodiments the flavivirus comprises Zika virus, spondweni virus, kedougous virus, or a combination thereof. In some embodiments, the flavivirus comprises Zika virus. In some embodiments, the suicide gene encodes a protein that converts a prodrug into a cytotoxic agent. In some embodiments, the viral composition is administered in combination with the immunostimulatory agent.
Owner:BLACK KEITH

Kit used for detecting brain glioma gene mutation, and preparation method

PendingCN112391464AGuaranteed specificityIncrease mutation hotspotsMicrobiological testing/measurementOncologyPseudoprogression
The invention belongs to the biotechnology field, and relates to a cerebrospinal fluid liquid state biopsy technology and a kit preparation method thereof, in particular to a detection kit for dynamically monitoring change of ctDNA in the cerebrospinal fluid of a glioma patient through detection of hotspot gene mutation, and a preparation method of the detection kit. The invention mainly takes brain glioma and meningioma as detection objects, on the basis of a high-throughput gene sequencing detection method, the change of the ctDNA in the cerebrospinal fluid of the glioma patient and a meningioma patient, and main mutation genes related to the glioma and the meningioma are screened to establish a liquid state biopsy gene kit. Through dynamic monitoring of the gene change of the glioma patient before / after an operation, radiotherapy and chemotherapy, a gene-oriented glioma molecular diagnosis, including minimal residual disease surgical excision, pseudoprogression or recurrence, is carried out, and reaction for the radiotherapy and the chemotherapy and change of drug tolerance are monitored.
Owner:AFFILIATED HUSN HOSPITAL OF FUDAN UNIV

Somatostatin agonists

The present invention is directed to cyclic peptides of formula (I): X-A1-cyclo(D-Cys-A3-A4-Lys-A6-A7)-A8-Y, or a pharmaceutically acceptable salt thereof. The peptides bind selectively to the somatostatin subtype receptor type-5 and elicit an agonist effect from the somatostatin subtype receptors. The peptides are useful for treating a variety of diseases, including Cushings Syndrome, gonadotropinoma, hyperparathyroidism, Paget's disease, VIPoma, nesidioblastosis, hyperinsulinism, gastrinoma, Zollinger-Ellison Syndrome, hypersecretory diarrhea related to AIDS and other conditions, irritable bowel syndrome, pancreatitis, Crohn's Disease, systemic sclerosis, thyroid cancer, psoriasis, hypotension, panic attacks, sclerodoma, small bowel obstruction, gastroesophageal reflux, duodenogastric reflux, Graves' Disease, polycystic ovary disease, upper gastrointestinal bleeding, pancreatic pseudocysts, pancreatic ascites, leukemia, meningioma, cancer cachexia, acromegaly, restenosis, hepatoma, lung cancer, melanoma, inhibiting the accelerated growth of a solid tumor, decreasing body weight, treating insulin resistance, Syndrome X, prolonging the survival of pancreatic cells, fibrosis, hyperlipidemia, hyperamylinemia, hyperprolactinemia and prolactinemia.
Owner:IPSEN PHARMA SAS

Traditional Chinese medicine composition for treating intracranial tumors

The invention provides a traditional Chinese medicine composition for treating intracranial tumors. The traditional Chinese medicine composition comprises more than thirty Chinese herbal medicines including centipede, scorpion, longnosed pit viper, dahurian angelica root, Siberian cocklour fruit, biond magnolia flower bud, tall gastrodia tuber, lucid ganoderma, Chinese caterpillar fungus and the like. The traditional Chinese medicine composition has the effects of detoxifying and inducing resuscitation, resolving phlegm and alleviating mental depression, eliminating swelling and softening hard masses, nourishing the liver and kidneys and the like, and adopts simultaneous elimination and reinforcement for treating intracranial tumors. The traditional Chinese medicine provided by the invention has significant curative effects on intracranial benign and malignant tumors including various types of gliomata, pituitary tumors, meningioma, craniopharyngioma, pinealoma, cavernous tubercule, neurilemmoma, chordoma, metastatic encephaloma and the like, and can enable tumor cells to loss reproductive capacity so as to ensure that tumor bodies are gradually reduced, calcified or disappeared.
Owner:SHANDONG PROVINCIAL HOSPITAL

Traditional Chinese medicine composition for treating recurrence of meningiomas after surgery

The invention relates to a traditional Chinese medicine composition for treating recurrence of meningiomas after the surgery. The traditional Chinese medicine is characterized by comprising the following raw materials: 6-9g of frankincense, 6-8g of myrrh, 3-6g of stiff silkworm, 6-10g of salvia chinensis, 6-10g of curcuma zedoary, 3-6g of edible tulip, 6-8g of ligusticum wallichii, 6-8g of red-rooted salvia root, 4-6g of radix angelicae, 6-8g of red peony root, 4-6g of caulis spatholobi, 3-6g of sculellaria barbata, 3-6g of self heal, 4-6g of mangnolia officinalis, 4-6g of coix seed, 6-8g of codonopsis pilosula, 4-6g of angelica, 4-6g of tuckahoe, 4-6g of rhizoma alismatis and 4-6g of liquorice. The traditional Chinese medicine composition has the beneficial effects of promoting blood circulation for removing blood stasis, supporting the healthy energy, resolving hard lump and inducing diuresis to alleviate edema. The traditional Chinese medicine composition has the characteristics of good treatment effect, high remission rate, low cost and low toxic side effect. The recurrence of meningiomas is dialectically treated according to different symptom patterns in clinical science.
Owner:郭文斌

Method for isolating and culturing human meningioma cells

The invention belongs to the biomedical field and relates to a method for isolating and culturing meningioma cells and in particular relates to a method for isolating meningioma cells from isolated human meningioma tissues and subculturing the meningioma cells. The method is characterized by adopting a cocktail type combined enzyme to digest the isolated human meningioma tissues stepwise to obtain meningioma cell suspension and carrying out low-oxygen culture on the meningioma cell suspension in a specific culture solution to obtain primary meningioma cells; and carrying out suspension culture on the obtained primary meningioma cells in the specific culture solution under the low-oxygen condition until more than 15 generations of meningioma cells are obtained. The method has the advantages that the cocktail type combined enzyme and the stepwise digestion method are beneficial to preserving cell viability, so that the cells obtained through digestion are basically viable cells, thus providing cell sources for primary culture of meningioma cells; and the method is beneficial to isolation and proliferation of meningioma cells and provides cell sources for further carrying out meningioma mechanism and drug screening researches.
Owner:AFFILIATED HUSN HOSPITAL OF FUDAN UNIV

Traditional Chinese medicine composition for treating meningioma and preparation method thereof

The invention discloses a traditional Chinese medicine composition for treating meningioma. The traditional Chinese medicine composition consists of rhizoma pinellinae praeparata, rhizoma typhonii, bile arisaema, rhizoma gastrodiae, rhizoma acori graminei, radix curcumae, fructus trichosanthis, tangerine peel, fructus aurantii immaturus, semen brassicae, herba asari, cassia seed, flos chrysanthemi, polyporus umbellatus, rhizoma alismatis, Indian iphigenia bulb, uncaria rhynchophylla, centipede, caesalpinia sappan, livistona chinensis, herb of wusheng clematis, paris polyphylla and rhizoma smilacis glabrae according to a certain weight proportion. The traditional Chinese medicine composition has the functions of clearing heat, resolving phlegm, calming endogenous wind, relieving convulsion, opening orifice, eliminating phlegm, moving qi and resolving stasis and can be used for effectively treating meningioma.
Owner:周文

Integral resection method of huge and super huge meningioma

The invention relates to meningioma resection, in particular to an integral resection method of huge and super huge meningioma, aiming to solve the problem that existing piecemeal resection method of huge and super huge meningioma has the shortages of long time, big trauma and much bleeding. The integral resection method includes the following steps: (1) the endocranium adhere to meningioma basement is operated circular incision and the meningioma gradually delivers through the incision; (2) blood vessels related to the meningioma are separated, protected or blocked in the process of the meningioma gradually delivering; (3) the cerebral cortex deep in the meningioma is protected in the process of the meningioma delivering out of the incision. The integral resection method has the advantages of short resection time, little bleeding, light operation trauma and small patient reaction. Through the integral resection method, patients have fast recovery and less complication and the meningioma is removed clean.
Owner:BEIJING TIANTAN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV

Methods of using LEDGF/p75

The invention provides methods for diagnosing tumors in mammals using a reagent that bind to LEDGF / p75 or to a nucleic acid encoding LEDGF / p75. For example, the tumor may be located in the CNS, the prostate, the skin, the bone marrow, or the gut of the mammal. Also provided are methods for diagnosing brain tumors such as medulloblastomas, meningiomas, astrocytomas, glioblastomas multiforme, and ependymomas by examining LEDGF / p75 or a nucleic acid encoding LEDGF / p75 localization. The invention also involves methods for diagnosing cancers involving cancerous epithelial cells such as colon cancer. The instant invention also provides methods for isolating stem cells from a heterogeneous population of cells, as well as methods for identifying neuroepithelial stem cells, newly differentiated neurons, and astrocytes in a subject. Also provided are methods for inducing the differentiation of neuroepithelial stem cells into astrocytes or neurons and methods for screening candidate compounds that regulate the differentiation of neuroepithelial stem cells.
Owner:THE BRIGHAM & WOMEN S HOSPITAL INC

Brain image meningioma full-automatic screening and tumor segmentation method and device

The invention provides a brain image meningioma full-automatic screening and tumor segmentation method and device. The brain image meningioma full-automatic screening and tumor segmentation method comprises the following steps of S1, performing format conversion on an image file of a meningioma patient; s2, preprocessing the image of the image file after format conversion; s3, carrying out enhancement processing on the image data in the preprocessed image file; s4, screening the enhanced image data to obtain a slice image containing meningioma, and storing the slice image; s5, segmenting the slice image containing the meningioma to obtain a meningioma segmentation result image, and storing the meningioma segmentation result image; and S6, performing post-processing on the slice image containing the meningioma and the meningioma segmentation result image. According to the method, classification and segmentation technologies of deep learning are combined, the method has the advantages of being noninvasive, repeatable, batched and capable of improving clinical diagnosis efficiency of doctors, and assistance can be provided for meningioma imaging omics research and clinical doctor operation scheme making.
Owner:AFFILIATED HUSN HOSPITAL OF FUDAN UNIV

Method For Radical Removal of Parasagittal Meningioma

InactiveUS20030105507A1Restoring and securing blood flowDiagnosticsSurgeryNeurosurgeryBase of the sacrum
Abstract of Disclosure The present invention relates to medicine and more particularly to neurosurgery, and can be used in the operative treatment of patients with parasagittal meningiomas. The present invention is directed to the provision of radical removal of a parasagittal meningioma, restoring and securing natural blood flow, obviating recurrent parasagittal meningioma. The object is accomplished by that semicircular incisions of the dura mater circumscribing the tumor contour are made toward the base of the upper sagittal sinus, the tumor is removed as a single block together with a segment of the upper sagittal sinus and a portion of the falx cerebri, whereafter the removed segment of the upper sagittal sinus is replaced with an implant prosthesis ensuring physiological blood flow. The prosthesis is a cynlindrical tubular member in which the end parts are provided with smooth, curvilinear, gently sloping bevels made on its internal generating surface or on both internal and external surfaces thereof.
Owner:SVADOVSKIY ALEKSANDR IGOREVICH

Formula of traditional Chinese medicine for treating meningioma

The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a formula of a traditional Chinese medicine for treating meningioma. The traditional Chinese medicine is characterized by being prepared from the following traditional Chinese medicine raw materials in parts by weight: 25-30 parts of fructus ligustri lucidi, 25-30 parts of radix morindae officinalis, 10-15 parts of radix polygoni multiflori preparata, 15-20 parts of semen cuscutae, 25-30 parts of radix campanumoeae, 10-15 parts of radix astragali seu hedysari, 15-20 parts of herba ludisiae discoloris, 10-15 parts of turtle shell, 10-15 parts of denseflower dendrobium, 15-20 parts of arisaema cum bile, 10-15 parts of radix gerberae delavayi, 10-15 parts of semen lepidii, 5-10 parts of radix curcumae, 5-10 parts of black nightshade herb and 5-10 parts of herba scutellariae barbatae. The formula of the traditional Chinese medicine for treating the meningioma has the advantages that the used traditional Chinese medicine raw materials conform to the regulations of the pharmacopoeia of the People's Republic of China, and the medicines are safe and reliable. By means of combination of all the medicines, the traditional Chinese medicine can treat both symptoms and root causes of the meningioma caused by disorder of qi activity, insufficient kidney and brain, phlegm stagnation and internal resistance as well as long-time poisoning; the traditional Chinese medicine has the characteristics of being obvious in curative effect, quick in response, high in cure rate, and the like.
Owner:栾雷

Application of carbon-21 steroid compound STA in preparation of Hedgehog pathway inhibitor and anticancer drugs

The invention provides application of a carbon-21 steroid compound STA in preparation of a Hedgehog pathway inhibitor and anticancer drugs. The structural formula of the carbon-21 steroid compound STA is described in the specification. The compound can be applied to preparation of drugs used for treating cancers including, but not limited to, basal cell carcinoma, medulloblastoma, rhabdomyosarcoma, pancreatic cancer, breast cancer, spinal meningioma, malignant glioma, melanoma, stomach cancer, liver cancer, esophageal cancer, bile duct cancer, prostatic cancer, colorectal cancer, small cell lung cancer, non-small cell lung cancer, neurogliocyte cancer, multiple myeloma, urogenital neoplasms and leukemia. Experiment results prove that the compound is capable of both inhibiting the Hedgehog pathway and inducing apoptosis of tumor cells.
Owner:ZHEJIANG ACAD OF MEDICAL SCI

Method of treating meningioma

The present invention relates to a method of treating meningioma including administering a Chinese medicine composition to a subject in need thereof; wherein the Chinese medicine composition is an extract of a first mixture comprising Coptis chinensis, Phellodendron amurense, Glycyrrhiza uralensis, Atractylodes lancea, Artemisia carvifolia, Anemarrhena asphodeloides, and Cortex Lycii.
Owner:JU DA-TONG

Chinese medicinal formula for treating meningioma

The invention belongs to the technical field of Chinese medicaments, and particularly relates to a Chinese medicinal formula for treating meningioma. The formula is characterized in that the medicament is prepared from the following Chinese medicinal raw materials in parts by weight: 25-30 parts of curculigo orchioides, 25-30 parts of cornus pulp, 10-15 parts of epimedium gradiflorum morr, 15-20 parts of wolfberry,, 25-30 parts of polygonatum kingianum, 10-15 parts of statice, 15-20 parts of dendrobium densiflorum, 10-15 parts of bulbophyllum psychoon, 10-15 parts of ludisia discolor, 15-20 parts of salvia substolonifera, 10-15 parts of fagopyrum cymosum root, 10-15 parts of draba nemorosa, 5-10 parts of rhizoma corydalis, 5-10 parts of rabdosia rubescens and 5-10 parts of salvia chinensis. The formula has the advantages that the adopted Chinese medicaments comply with the regulations of the People's Republic of China pharmacopoeia and are safe and reliable. The medicaments are compatible, treat both symptoms and root causes of meningioma caused by qi-ji disorder, insufficiency of the kidney and the brain, phlegm and blood stasis in the interior and long-time toxicity, and have the characteristics of exact treatment effect, quick response, high cure rate and the like for treating meningioma.
Owner:栾雷

Intra-operative intelligent navigation glasses for precisely cutting away intracranial space-occupying lesions

The invention relates to a pair of intra-operative intelligent navigation glasses for precisely cutting away intracranial space-occupying lesions. The pair of glasses includes a glasses body, an imagetransmission module, a central processing module and a display module; the glasses body comprises lenses, a glasses frame, glasses legs and a polymer lithium battery; the image transmission module can receive patient two-dimensional image data sent by a wireless terminal; the central processing module rebuilds the two-dimensional image data to obtain a three-dimensional depth image, and the transparency of the image is improved; the display module is used for displaying the three-dimensional depth image. Due to the fact that the three-dimensional depth image can display the lesion position, after a surgeon wears the pair of intelligent glasses, the image is adopted as a background, the built anfractuosity, gyrus, blood vessels and other structures in the image are compared with the surgery field actual anatomical structure, the surgery field reality scene can be enhanced, the lesion position can be determined, and then surgery is guided. The pair of glasses is high in precision, reasonable in design, easy to obtain, simple in structure, low in price and applicable to precisely cutting away the meningiomas and other intracranial space-occupying lesions.
Owner:陈吉钢 +2
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