The invention discloses enzyme supplementation gum which is composed of 0.1%-0.3% of muramidase, 18%-22% of aluminium hydroxide, 2%-3% of vitamin C, 0.6%-1% of citric acid, 2%-3% of glycerinum, 20%-30% of gum base, 40%-45% of sorbitol, 4%-6% of mannitol, 0.5%-1% of essence and 6%-10% of water. According to the enzyme supplementation gum, the biological muramidase and the citric acid are added, the pH value of the gum can keep the activity of the muramidase to the maximum degree, and bacteria resistance and bacteriostasis, dental calculus prevention, caries prevention, ozostomia relieving, dental plaque inhibition and remarkable improvement of gingival bleeding are conducted on the aspect of biology; the aluminium hydroxide and the vitamin C can assist the muramidase in removing dental plaque and stain, the effect is more remarkable, gingival bleeding is inhibited, and the gum can taste sour and sweet and delicious; the teeth can be healthy and white and breath can be fresh through long-term use of the enzyme supplementation gum.