The invention discloses ROS (
reactive oxygen species)-responsive macrophage-targeted 4OI-loaded
hydrogel microspheres, a microneedle dressing, a preparation method of the ROS-responsive macrophage-targeted 4OI-loaded
hydrogel microspheres and the microneedle dressing and novel medical application of the ROS-responsive macrophage-targeted 4OI-loaded
hydrogel microspheres and the microneedle dressing in burn wounds, and belongs to the technical According to the adopted scheme,
PLGA-TK-PEG-COOH is used as a carrier, 4OI is entrapped through a
microemulsion ultrasonic method, and then
mannose is connected through an amidation reaction for
surface modification. According to the hydrogel microspheres, ROS response accurate
drug release is realized by virtue of TK bonds, and advanced leakage of drugs is avoided;
mannose can target a macrophage surface
receptor, so that the delivery accuracy is improved. The hydrogel has the characteristics of high encapsulation efficiency, high ROS response and release at the diseased region, excellent
biocompatibility of the used materials, and simple and controllable preparation process. The 4OI
delivery system can be widely applied to treatment of related diseases such as
inflammation and tumors, can also be compounded to prepare a microneedle dressing to realize local deep administration, effectively solves the pain points of poor targeting property, large toxic and side effects and the like of the existing 4OI
delivery system, and has important clinical application value and industrialization prospect.