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767 results about "Wound treatment" patented technology

Wound Treatment. The following wound preparations may be recommended: Topical or systemic antibiotic therapy for wounds that are infected. Debridement of exudates and fibrous tissue to stimulate the growth of new epithelium. Absorbent dressings for heavily draining ulcers. Acetic acid. Silver nitrate dressings.

Robot-assisted wound treatment method and system based on multi-modal image analysis

The invention provides a multi-modal image analysis-based robot-assisted wound treatment method and system, and relates to the technical field of robots, and the method comprises the steps: collecting a multi-modal image of a to-be-treated wound, determining an image registration result, obtaining a wound region image through a multi-scale fusion algorithm and wound region segmentation, and carrying out the type classification of wound tissues. A wound tissue type classification result is obtained; performing surrounding shooting on a wound area to obtain a wound multi-view image, registering subsequent depth maps frame by frame by taking a first frame of depth map as a reference, accumulating point cloud data, determining a wound three-dimensional point cloud, generating a wound three-dimensional reconstruction result by combining a curved surface evolution algorithm, and determining a wound parameter measurement result; based on the wound tissue type classification result and the wound parameter measurement result, a robot path planning algorithm is adopted, the optimal movement track of the robot is generated, the movement parameters of the robot are adjusted in real time through a robot control algorithm of vision and force feedback, and wound adjuvant therapy is completed.
Owner:THE FIRST MEDICAL CENT CHINESE PLA GENERAL HOSPITAL

Negative pressure sealing drainage dressing and wound surface treatment device

The invention relates to the technical field of medical instruments, and provides a vacuum sealing drainage dressing and a wound surface treatment device.The vacuum sealing drainage dressing comprises a sealing layer and a dressing layer which are sequentially arranged in a stacked mode from top to bottom, and further comprises a drainage assembly; the drainage assembly comprises a sucker and a drainage tube, the sucker is arranged at the adsorption opening of the sealing layer, and the drainage tube is connected to the sucker; the dressing layer is of a porous structure, hole walls are communicated with one another to form a continuous channel, the dressing layer is provided with a flexible plasma patch, the flexible plasma patch is suitable for generating plasma acting on a wound surface, and the flexible plasma patch is provided with through holes communicated with pores. The flexible plasma patch is integrally arranged on the dressing layer, negative pressure drainage and wound sterilization and disinfection combined healing promoting treatment can be achieved, the wound or wound treatment process can be simplified, inconvenience caused by frequent dressing change is reduced, and the faster and better healing effect is achieved.
Owner:BEIJING MEDICAL PLASMA LABORATORY TECHNOLOGY CO LTD

Wound surface identification charging system based on precision medical treatment

The invention belongs to the technical field of medical image processing, and discloses a wound identification and charging system based on precision medical treatment, which realizes intelligent management of wound treatment through cooperative work of multiple modules. The method comprises the following steps: firstly, collecting a multi-angle digital image of a wound surface, performing standardization processing, performing image enhancement and noise reduction, and then performing identification and segmentation by using a deep learning algorithm; and performing three-dimensional reconstruction based on the accurate contour map to form parameter feature vectors, and performing intelligent wound type discrimination and severity evaluation. And according to an evaluation result, matching an optimal dressing change type and predicting required consumables, generating a precise dressing change scheme, and further calculating personalized charges and performing transparency verification. And finally, the system automatically generates a standardized medical service file through historical data comparison and rationality analysis. According to the system, the precision, standardization and transparency of wound treatment are realized, the medical service quality is improved, and the resource allocation is optimized.
Owner:THE SECOND AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY

Mitochondria-targeted antioxidant hybrid vesicle as well as preparation method and application thereof

The invention provides a preparation method of mitochondria-targeted antioxidant hybrid vesicles. The preparation method comprises the following steps: S1, preparing and separating adipose-derived stem cell nano-vesicles; s2, preparing a liposome loaded with dihydromyricetin and distearoyl phosphatidyl ethanolamine-polyethylene glycol 2000-triphenylphosphine targeting peptide by an ethanol injection method; and S3, preparing the hybrid nano vesicles loaded with the dihydromyricetin and the distearoyl phosphatidyl ethanolamine-polyethylene glycol 2000-triphenylphosphine targeting peptide. The invention also provides the hybrid vesicles prepared by the method and application of the hybrid vesicles in preparation of refractory diabetes wound treatment drugs. The lipidosome and the adipose-derived stem cell nano-vesicles are hybridized to prepare the hybridized vesicles capable of targeting mitochondria and resisting oxidation, the hybridized vesicles are applied to wound treatment for the first time, the problem of oxidative stress of diabetic wounds is solved, wound healing is accelerated, and a new strategy is provided for optimizing mitochondrial function defects and oxidative stress of the diabetic wounds.
Owner:XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV

Wound dressing capable of preventing seawater self-adhesion and rapidly stopping bleeding and preparation method of wound dressing

The invention belongs to the technical field of medical materials, and particularly relates to a seawater self-adhesive wound dressing capable of rapidly stopping bleeding and a preparation method of the seawater self-adhesive wound dressing. The electrospun fiber wound dressing provided by the invention contains an efficient hemostatic, and can quickly promote blood coagulation, shorten the hemostasis time and provide timely and effective first-aid measures for patients. By means of the multi-layer structural design, especially the self-adhesive waterproof layer, seawater permeation can be effectively prevented, wounds are protected against seawater erosion, and the infection risk is reduced. The composite breathable film with the gradient aperture design is adopted, it can be guaranteed that water vapor in the wound area is discharged smoothly, invasion of outside moisture and bacteria can be blocked, and the wound is kept dry and clean. The electrospun fiber wound dressing provided by the invention has the advantages of rapid hemostasis, seawater erosion prevention, excellent self-adhesion, good air permeability, structural stability and the like, and is a wound dressing suitable for wound treatment in marine emergency rescue and daily marine activities.
Owner:CHINESE PEOPLES LIBERATION ARMY UNIT 32181

Perianal drug dressing made of multi-layer diversion composite fabric, preparation method and application of perianal drug dressing

The invention relates to the technical field of medical dressings, in particular to a perianal drug dressing of a multi-layer flow guide composite fabric and a preparation method and application of the perianal drug dressing of the multi-layer flow guide composite fabric. The perianal drug dressing is of a four-layer structure, a wet tissue adhesion layer is made of polydopamine modified chitosan / oxidized hyaluronic acid hydrogel, and wet-state adhesion is achieved; the drug sustained-release layer is used for dispersing mesoporous silica loaded with ciprofloxacin hydrochloride / defensin and chitosan microspheres loaded with epidermal growth factors / lonicera japonica into a polycaprolactone fiber membrane to achieve synergistic antibacterial and healing promotion; the directional flow guide layer is of a gradient wettability sandwich structure with a bionic micro-channel, and one-way rapid drainage can be achieved; the high-absorption outer layer is carboxymethyl cellulose / sodium polyacrylate composite sponge, liquid is locked efficiently, the wound surface is kept dry and comfortable, the clinical problem in perianal infection wound treatment can be effectively solved, and the treatment effect and the patient comfort are remarkably improved.
Owner:ZHUHAI JIANLANG DAILY NECESSITIES CO LTD

Photo-thermal controlled-release nitric oxide anti-biofilm hydrogel based on click reaction crosslinking as well as preparation method and application of photo-thermal controlled-release nitric oxide anti-biofilm hydrogel

The invention discloses photo-thermal controlled-release nitric oxide anti-biofilm hydrogel based on click reaction crosslinking as well as a preparation method and application of the photo-thermal controlled-release nitric oxide anti-biofilm hydrogel based on click reaction crosslinking, the hydrogel is prepared by taking azide group-containing four-arm polyethylene glycol and alkynyl modified hyaluronic acid as matrixes through click chemistry rapid crosslinking under the catalysis of copper-based nanoparticles, the antibacterial biological membrane has remarkable dual anti-biological membrane and anti-inflammatory effects, and can be applied to wound treatment of bacterial biological membrane infection; through a wound surface coating form, under near-infrared light irradiation, copper nanoparticles generate a mild photothermal effect to remove a biological membrane, and Cu < 2 + > is released to promote fibroblast proliferation; nitric oxide can be controllably released, a biological membrane is synergistically eliminated by enhancing lipid peroxidation and destroying a bacterial membrane structure, meanwhile, angiogenesis is promoted, collagen deposition is stimulated, and the wound healing process is accelerated; the invention has the functions of efficient antibiosis and tissue regeneration, and has wide clinical application prospect and development value in the field of infectious wound treatment.
Owner:CHINA PHARM UNIV

Natural light crosslinked hydrogel comprising mxene and method for preparing same

The present invention relates to a natural light crosslinked hydrogel comprising MXene and a method for preparing same. The present invention provides a natural polymeric hydrogel formed through natural light crosslinking in a non-harmful visible light spectrum. As the hydrogel comprises a drug and MXene, the hydrogel exhibits excellent biocompatibility with no cytotoxicity. It has been confirmed that the hydrogel can maximize a wound healing effect by modulating photothermal reactions and controlling drug release. Accordingly, the hydrogel may be effectively used for wound treatment as a pharmaceutical composition, a quasi-drug composition, and a cosmetic composition.
Owner:DANKOOK UNIV CHEONAN CAMPUS IND ACADEMIC COOP FOUND

Negative pressure wound treatment apparatuses and methods with integrated electronics

Disclosed herein are embodiments of a wound treatment apparatus with electronic components integrated within a wound dressing. In some embodiments, a wound dressing apparatus can comprise a wound dressing. The wound dressing can comprise an absorbent material, an electronics unit comprising a negative pressure source, the electronics unit integrated within the wound dressing and at least partially encapsulated by a flexible film. The flexible film can comprise a window or aperture configured to permit fluid communication between the absorbent material and the negative pressure source. In some embodiments, a wound dressing apparatus can comprise a wound contact layer, an absorbent layer over the wound contact layer, the absorbent layer comprising one or more apertures, a cover layer configured to cover and form a seal over the wound contact layer and the absorbent layer, and an electronics assembly comprising a negative pressure source. A portion of the cover layer overlying the one or more apertures in the absorbent layer can be configured to be compressed within the aperture in the absorbent layer when negative pressure is applied to the wound dressing apparatus. The compressed cover layer can indicate a level of negative pressure below the cover layer. In some embodiments, the wound dressing apparatus can comprise an indicator material layer and a cover layer configured to cover and form a seal over the wound contact layer and the indicator material layer. The indicator material layer can be configured to protrude relative to a surrounding surface of an upper surface of the wound dressing apparatus when negative pressure is applied to the wound dressing apparatus and the protruding indicator material layer indicates a level of negative pressure below the cover layer.
Owner:SMITH & NEPHEW PLC

Esophagus medicine applying system applied to digestive system department

The invention relates to the field of surgical esophagus medicine applying, in particular to an esophagus medicine applying system applied to the gastroenterology department, comprising: a medicine injection module comprising a nozzle and an image acquisition assembly; the conveying module comprises a medicine conveying pipe, a flow velocity sensor, a gas flow velocity sensor and a conveying pump; the model construction module is used for generating a three-dimensional model of the esophageal wound surface according to the image of the esophageal wound surface; the control module is used for determining an esophageal peristalsis mode according to the esophageal wound surface three-dimensional model, determining a spraying mode according to the peristalsis mode, including determining a medicine spraying pressure according to a gas flow rate in the esophagus, or determining a medicine spraying distance according to an esophageal liquid flow rate of the esophageal wound surface of a patient, and determining a medicine spraying distance according to the medicine spraying distance. And re-determining the medicine injection distance according to the medicine distribution area of the esophageal wound surface. According to the invention, the accuracy and efficiency of surgical esophageal wound treatment are improved.
Owner:THE SECOND AFFILIATED HOSPITAL TO NANCHANG UNIV

Wound healing state evaluation system based on multi-modal image mode recognition

The invention discloses a wound healing state evaluation system based on multi-modal image mode recognition, relates to the technical field of mode recognition, and aims to construct a multi-modal and three-dimensional wound monitoring network structure and improve the accuracy and coverage dimension of wound tissue distribution monitoring, so that efficient and accurate healing state evaluation decision is realized. The healing process and patient individual differences are considered, the monitoring precision and diagnosis response speed of wound healing state evaluation are improved, the healing efficiency and rehabilitation effect in the wound treatment process are remarkably improved, the skin gray threshold value and the deformation index threshold value can be dynamically adjusted according to the individual characteristics of different patients, and the healing effect is improved. The continuous influence of tissue state misjudgment on healing evaluation is effectively prevented, evaluation deviation and treatment delay caused by subjective judgment are avoided, differential evaluation can be performed according to different skin types and healing characteristics, and the intelligent level of wound healing state evaluation and the precision of clinical application are effectively improved.
Owner:THE 971ST HOSPITAL OF THE CHINESE PEOPLES LIBERATION ARMY NAVY

Wound treatment sequence recommendation method and device based on reinforcement learning and medium

The invention belongs to the technical field of medical detection, and discloses a wound treatment sequence recommendation method and device based on reinforcement learning and a medium, and the method comprises the steps: constructing a wound decision knowledge base, carrying out the unified coding of multi-modal wound data, mapping the data to a same dimensional space, and generating a feature vector; constructing a reinforcement learning model, training the reinforcement learning model by using the historical trauma data, and optimizing a decision strategy of the reinforcement learning model through composite reward calculation and adversarial training; identifying and processing the trauma image to complete trauma severity evaluation; and according to the evaluation result, generating a treatment priority recommendation, and feeding back the wound evaluation result and the treatment priority in real time. By introducing the reinforcement learning model, the wound type and severity of the patient are automatically evaluated, and the personalized treatment priority is generated based on the wound type and severity. According to the automatic decision-making process based on data driving, subjectivity and delay of manual judgment are avoided, and the wound treatment efficiency is remarkably improved.
Owner:四川互慧软件有限公司

Antibacterial peptide PPI45 / PPI47 as well as preparation method and application thereof

The invention discloses an antibacterial peptide PPI45 / PPI47 as well as a preparation method and application of the antibacterial peptide PPI45 / PPI47. According to the invention, fungal defensin Plectasin is used as a template, and the self-assembled antibacterial peptide PPI45 / PPI47 is designed. The expression of the self-assembled antibacterial peptide PPI45 / PPI47 in pichia pastoris is realized by optimizing the gene sequence of the antibacterial peptide and constructing a specific expression vector, a perfect purification system is established, large-scale production can be realized, and the self-assembled antibacterial peptide PPI45 / PPI47 can be applied to the fields of antibacterial drug development, hydrogel wound treatment and the like, and has wide application value and market prospect.
Owner:FEED RESEARCH INSTITUTE CHINESE ACADEMY OF AGRICULTURAL SCIENCES

Self-generating full-layer artificial skin for wound treatment and application of self-generating full-layer artificial skin

The invention relates to artificial skin, in particular to self-generating full-layer artificial skin for wound treatment and application of the self-generating full-layer artificial skin. The artificial epidermis has an epidermis-dermis structure similar to skin, and the artificial epidermis structure is composed of an electrostatic spinning nano-film with piezoelectric capacity and has the functions of sterilization, protection and bioelectricity generation of an epidermis layer; the artificial dermal structure is composed of a photo-crosslinking polysaccharide and enzyme crosslinking protein interpenetrating hydrogel skeleton, by adding bioactive components and loading living cells, the effects of releasing active components and cytokines, remodeling wound extracellular matrix and promoting cell proliferation are achieved, and finally healing of acute and chronic wounds is remarkably accelerated. The invention provides a simple, feasible, economical and effective treatment method for sealing a large-area wound, sterilizing the wound and promoting healing of the wound.
Owner:CHINA PHARM UNIV

Intelligent hemostasis system and method

ActiveCN119606476AMedical simulationEvaluation of blood vesselsWar injuriesTime to hemostasis
The invention relates to the technical field of clinical medical treatment, in particular to an intelligent hemostasis system and method. Blood pressure, heart rate, hemostasis pressure, patient body data and patient wound data are collected through the hemostasis device, a hemostasis time-pressure prediction model is constructed through a differential evolution algorithm and a WaveNet model, prediction of a relation curve of the hemostasis pressure and the hemostasis time is achieved, and the hemostasis pressure and the hemostasis time are predicted through the relation curve. The hemostasis device can adjust the pressure applied by the hemostasis device according to needs, and the problems that in the war wound treatment process, the hemostasis pressure of a tourniquet is too large, the hemostasis time is too long, consequently, limbs or pressed local parts are necrotic, and the hemostasis effect is poor due to the too small pressure are solved.
Owner:THE FIRST MEDICAL CENT CHINESE PLA GENERAL HOSPITAL

Exosome derived from endometrial mesenchymal stem cells and application of exosome in preparation of medicine for treating diabetic wounds

The invention provides an endometrial mesenchymal stem cell-derived exosome and application thereof in preparation of a medicine for treating diabetic wounds, and belongs to the technical field of biological medicines. The endometrial mesenchymal stem cell-derived exosome provided by the invention can effectively promote HUVEC tube forming ability, promote wound angiogenesis of diabetic model mice, increase collagen deposition and reduce wound area, finally achieves the purpose of promoting healing of diabetic wounds, and solves the problem of limited treatment effect of exosomes in the prior art. The endometrial mesenchymal stem cell-derived exosome provided by the invention can be used as a medicine for promoting angiogenesis and wound healing to be applied to diabetes wound treatment, and also provides a new strategy for treatment of other chronic wounds including burn.
Owner:SHANXI MEDICAL UNIV

PD-L1 and Siglec-15 enriched engineered small extracellular vesicle hydrogel as well as preparation method and application thereof

The invention relates to the technical field of biomedical materials, in particular to engineered small extracellular vesicle hydrogel enriched with PD-L1 and Siglec-15 as well as a preparation method and application of the engineered small extracellular vesicle hydrogel. The engineering small extracellular vesicle hydrogel is enriched with PD-L1 and Siglec-15 at the same time, the engineering small extracellular vesicle hydrogel comprises a hydrogel base body and PDL1-Siglec15-sEVs loaded in the hydrogel base body, and the PDL1-Siglec15-sEVs are small extracellular vesicles with the PD-L1 and the Siglec-15 in an overexpression mode. Compared with natural small extracellular vesicles and a traditional wound surface treatment strategy, the engineered small extracellular vesicle hydrogel has the advantages that PD-L1 and Siglec-15 can be enriched in the vesicles, so that more accurate immune microenvironment regulation and control can be realized on the local part of a wound surface, excessive inflammatory response is moderately inhibited, phenotype transformation of macrophages to be beneficial to tissue regeneration is promoted, and the wound surface treatment effect is improved. The hydrogel is used as a carrier and can provide a moist healing environment and a three-dimensional scaffold structure, so that the residence time of the engineered small extracellular vesicles on the local wound surface is remarkably prolonged, and slow release is realized.
Owner:SHANGHAI FIRST PEOPLES HOSPITAL

Distributed negative pressure wound therapy system incorporating an absorbent dressing and piezo-electric pump

A negative pressure wound therapy system includes a wound dressing, at least one pump fluidly coupled to the fluid interface, a pressure sensor fluidly coupled to the wound dressing, a control housing, and an electrical coupler. The wound dressing includes a sealing layer, an absorbent layer adjacent to the sealing layer, and a fluid interface attached to at least one of the sealing layer or the absorbent layer. The at least one pump is configured to apply negative pressure to the fluid interface to draw fluid from the wound dressing via the fluid interface. The pressure sensor is configured to detect a fluid pressure of the wound dressing. The control housing is remote from the wound dressing. The electrical coupler is configured to removably connect the control housing to the at least one pump.
Owner:SOLVENTUM INTELLECTUAL PROPERTIES CO

Systems and devices for wound therapy and related methods of use

Disclosed herein are systems and devices for wound therapy and related methods of use. The systems and devices for wound therapy and related methods of use disclosed herein may comprise one or more cartridges for preparation of a regenerative epidermal suspension. One or more cartridges for preparation of a regenerative epidermal suspension may comprise a cover with a raised processing opening, a cup that can be received within the raised processing opening and has a screen, and a well plate that is positioned under the cover, has a well, and rotates relative to the cover such that the well aligns with the raised processing opening. One or more cartridges for preparation of a regenerative epidermal suspension comprises a cover with an opening that can receive a tissue sample.
Owner:AVITA MEDICAL AMERICAS LLC

Bio-based gel dressing for wound treatment and preparation method thereof

The invention belongs to the technical field of gel dressings, and particularly relates to a bio-based gel dressing for wound treatment and a preparation method thereof.The bio-based gel dressing is prepared from, by weight, 10-17 parts of mussel mucin, 13-20 parts of silk fibroin, 1-5 parts of plant vesicles, 2-4 parts of traditional Chinese medicine polysaccharide, 0.05 part of antibacterial peptide, 1.5 parts of glycerinum and 0.3 part of cross-linking agent; nano plant vesicles which are extracted from a traditional Chinese medicine prescription and have the effect of promoting wound healing are used as a carrier for encapsulating antibacterial peptide, and then the antibacterial peptide is encapsulated in a three-dimensional gel network formed by natural protein, so that controlled release and slow release of antibacterial and anti-inflammatory components are realized, and efficient wound healing is promoted.
Owner:CHANGZHOU VOCATIONAL INST OF ENG

Modular negative pressure wound therapy devices, systems, and methods

Apparatuses, systems, and methods in a negative pressure wound therapy environment. A therapy device can include a pump housing and a power module configured to couple to the pump housing. The pump housing comprises a pump configured to deliver negative pressure to a dressing, a first pressure sensor configured to sense a pressure at the pump, a controller operably coupled to the pump and the first pressure sensor within an interior of the pump housing, and a first communications connector configured to provide communication with the controller from an exterior of the pump housing. The power module comprises a battery configured to provide power, a second pressure sensor configured to sense an ambient pressure, and a second communications connector configured to be coupled to the first communications connector to operably connect the battery and the second pressure sensor to the controller.
Owner:SOLVENTUM INTELLECTUAL PROPERTIES CO

Closed negative pressure device for wound treatment

The utility model relates to the field of negative pressure treatment equipment, in particular to a closed negative pressure device for wound treatment. Comprising a drainage tube, a flushing part and sponge arranged over a wound surface in an attached mode. The flushing part comprises a flushing pipe with one end provided with a flushing fluid access head, and a plurality of fluid outlet side holes are formed in the side wall of the other end of the flushing pipe. A plurality of liquid suction side holes are formed in the side wall of one end of the drainage tube, and the section, provided with the liquid suction side holes, of the drainage tube and the section, provided with the liquid outlet side holes, of the flushing tube are arranged in the sponge side by side; the other end of the drainage tube is connected with a negative pressure tube communicated with a negative pressure source; a fixing pasting film used for sealing the periphery of the sponge and fixing the drainage tube, the flushing tube and the sponge is attached to the wound surface. The closed type negative pressure device has the advantages that the closed type negative pressure device provides a negative pressure type circulation supply treatment means for patients, and the whole device is compact, simple, efficient and reliable; the treatment and nursing intensity of medical staff is relieved, meanwhile, the treatment effect is guaranteed, and consumables and time cost for treatment are obviously reduced.
Owner:TAOJIANG COUNTY MATERNAL & CHILD HEALTH HOSPITAL (TAOJIANG COUNTY CHILDRENS HOSPITAL)

Drainage tube orifice anti-seepage device

The utility model relates to the technical field of medical instruments, in particular to a drainage tube orifice seepage prevention device which comprises a bowl-shaped seepage collection cavity, an annular pasting part is arranged at the edge of the seepage collection cavity, and the pasting part is coated with medical colloid to be pasted to a drainage tube orifice of a patient; a main pipe opening is formed in the seepage collecting cavity and allows the main drainage pipe to penetrate through, and an anti-seepage structure is arranged at the main pipe opening to prevent seepage liquid from leaking from the main pipe opening. An auxiliary drainage tube is arranged on the seepage collecting cavity, seepage at a drainage tube opening can be collected through the seepage collecting cavity and then drained away from the auxiliary drainage tube, and seepage leakage is avoided; the device body is extremely small, other wound treatment measures are not affected, meanwhile, liquid drainage is rapid, and the device cannot fall off due to dead weight caused by accumulation of a large amount of seepage; the problem of leakage of leakage liquid at the drainage tube opening can be effectively solved, and meanwhile, adverse effects on the main drainage tube are avoided; the main drainage tube can be supported, the main drainage tube is kept to be vertically inserted into the body of a patient, and the seepage risk caused by wound damage is reduced.
Owner:PEOPLES HOSPITAL OF ZHENGZHOU

Antibacterial nanoparticle-loaded pH-responsive collagen microneedle patch as well as preparation method and application of antibacterial nanoparticle-loaded pH-responsive collagen microneedle patch

The invention relates to the technical field of biological materials, in particular to a pH response collagen microneedle patch loaded with antibacterial nanoparticles as well as a preparation method and application of the pH response collagen microneedle patch loaded with the antibacterial nanoparticles, and the microneedle patch is prepared by loading the antibacterial nanoparticles, aldehyde modified F127 and recombinant three-type collagen COL3 on a polymer matrix. When the microneedle patch is applied to a chronic wound of a diabetic patient, the microneedle penetrates through the skin in a minimally invasive mode and directly reaches a wound focus area. Under the irradiation of 808nm near-infrared light, the mesoporous polydopamine absorbs light energy, so that the loaded lyase LysAB2 is quickly released, bacterial cell walls are specifically recognized and cracked, and bacteria are efficiently killed; meanwhile, the collagen hydrogel constructs an appropriate microenvironment at the wound, cell adhesion, proliferation and migration are promoted, and the wound healing process is accelerated. Compared with a traditional diabetes mellitus chronic bacterial infection wound treatment means, the microneedle patch provided by the invention provides an efficient and safe new strategy for treating the chronic bacterial infection wound of a diabetes mellitus patient.
Owner:CHANGZHOU UNIV

Efficient debridement and negative pressure wound treatment device and system

The invention relates to the technical field of wound treatment devices, and discloses an efficient debridement and negative pressure wound treatment device and system.The efficient debridement and negative pressure wound treatment device comprises a storage cylinder, a suction pipe opening of an air pump is fixedly communicated with the interior of a net cover at the top of the storage cylinder, the air pump is fixedly installed on the outer wall of the storage cylinder, and the side wall of the top of the storage cylinder is fixedly communicated with the other end of a communicating pipe; the other end of the communicating pipe fixedly communicates with the end of the negative pressure cylinder, and the negative pressure cylinder is fixedly installed at the end of the first connecting cylinder in a penetrating mode. The second connecting cylinder is coaxially and fixedly connected to the outer wall of the side, away from the negative pressure cylinder, of the first connecting cylinder. According to the efficient debridement and negative pressure wound treatment device and system, a wound can be automatically cleaned, so that the working efficiency is improved, in the cleaning process, the wound can be retracted, so that the debridement effect is improved, and meanwhile, after debridement is completed, medicine applying operation can be conducted.
Owner:SHANDONG XINLONG MEDICAL SUPPLIES CO LTD

A mussel-inspired multifunctional dual-network crosslinked hydrogel wound dressing

The application discloses a mussel-inspired multifunctional double-network crosslinked hydrogel wound dressing. A hydrogel network formed by dynamic covalent crosslinking between carboxymethyl chitosan and oxidized sodium alginate is utilized; further, a natural antioxidant, gallic acid, with a catechol structure is introduced to enhance the tightness of the hydrogel network combination and endow the hydrogel with certain adhesion and antioxidant properties; finally, a mussel adhesive fluid containing catechol and iron is imitated to have strong tissue adhesion behavior under alkaline conditions, which is suitable for dynamic wound treatment, so as to prepare a mussel-inspired multifunctional double-network crosslinked hydrogel wound dressing. In addition, catechol-Fe 3+ Metal coordination also shows strong antibacterial effect, and under the irradiation of near-infrared light, light energy can be converted into heat energy for preventing and treating wound infection, shortening wound closure time and preventing scar formation.
Owner:SHANDONG UNIV

Self-testing for negative pressure wound therapy devices

A negative pressure wound therapy device can include a negative pressure source configured to be connected, via a fluid flow path, to a wound, a valve positioned in the fluid flow path and configured to, in an open state, permit supply of negative pressure from the negative pressure source upstream of the valve and, in a closed state, block supply of negative pressure from the negative pressure source upstream of the valve, a flow restrictor positioned in the fluid flow path, and a pressure sensor configured to measure a pressure differential across the flow restrictor. The device can include control circuitry configured to, in a normal operational mode, cause the valve to be in the open state and, in a test mode, perform at least one of a leak test, a flow test, or an excessive pressure test.
Owner:T J SMITH & NEPHEW

Medical systems, devices, and related methods for wound therapy

A medical system that includes a handle, a shaft extending distally from the handle, and a cap assembly coupled to the distal end of the shaft. The shaft includes one or more channels extending between the handle and a distal end of the shaft, and the cap assembly includes an opening that is configured to expose the one or more channels at the distal end of the shaft. The cap assembly includes a chamber that extends distally from the opening. The medical system includes a porous body movably disposed within the chamber. The porous body is configured to transition from a compressed configuration when disposed inside the chamber to an expanded configuration upon extending outwardly from the chamber.
Owner:BOSTON SCIENTIFIC SCIMED INC

Wound treatment management using augmented reality overlay

At least a method is disclosed for visualizing sensor data from a sensor monitoring a wound. The method can include: receiving senor data generated by one or more sensors monitoring a wound of a patient, the wound being covered with a wound dressing; generating a graphical representation from the sensor data; and presenting the graphical representation to a user via augmented reality so that the graphical representation is overlaid on an area proximate to the patient from a viewing perspective of the user.
Owner:T J SMITH & NEPHEW

Method for culturing skin-derived stem cells and their uses

The present invention relates to a method for culturing skin-derived stem cells and uses thereof, and to a method for culturing skin-derived stem cells; skin-derived stem cells produced by the method; a pharmaceutical composition for skin regeneration or wound treatment comprising the skin-derived stem cells produced by the method, a culture thereof, or cells differentiated from the skin-derived stem cells as an active ingredient; a quasi-drug composition; and a cosmetic composition. According to the culture method of the present invention, stem cells can be effectively isolated and obtained from skin tissue. The obtained skin-derived stem cells have excellent pluripotency and self-renewal ability, and have excellent skin regeneration and wound treatment effects, and can therefore be usefully used for skin regeneration and wound treatment or improvement applications.
Owner:EWHA UNIV IND COLLABORATION FOUND +1