173results about How to "Promote wound healing" patented technology

An apparatus for cleansing wounds in which irrigant fluid from a reservoir connected to a conformable wound dressing and wound exudate from the dressing are recirculated by a device for moving fluid through a flow path which passes through the dressing and a means for fluid cleansing and back to the dressing. The cleansing means (which may be a single-phase, e.g. microfiltration, system or a two-phase, e.g. dialytic system) removes materials deleterious to wound healing, and the cleansed fluid, still containing materials that are beneficial in promoting wound healing, is returned to the wound bed. The dressing and a method of treatment using the apparatus.

A wound dressing suitable for use in negative pressure wound therapy system includes a cover layer adapted to establish a reservoir over a wound in which a negative pressure may be maintained. The cover layer includes an opening therein through which atmospheric gases and wound exudates may pass through the cover layer. A vacuum port is affixed to the cover layer, and establishes a substantially fluid tight seal about the opening in the cover layer. The vacuum port includes a hollow interior in fluid communication with the opening in the cover layer and a connector to facilitate connection to a vacuum source. A packing member is affixed to the cover layer, to provide a wound dressing that may be applied in a single step process. The packing member is adapted to fill the wound and support the cover layer when a negative pressure is applied to the reservoir.

The invention belongs to the field of high polymer material and medical technology, and particularly relates to adhesion prevention material formed by physical crosslinking hydrogel composition and a preparation method and application thereof. The hydrogel composition material is formed by mixture of two polymers or more than two polymers, the water system of the hydrogel composition material can be thermo-sensitively gelated along with the rise of temperature, i.e. when the temperature is lower than gel transformation temperature, the composition is liquid, when the temperature raises to sol-gel transformation temperature or above the sol-gel transformation temperature, the composition spontaneously forms gel; the polymer generally is segmented copolymer formed by polyethylene glycol (PEG) being hydrophilic block and degradable polyester being lyophobic block, and polymer for mixing singly possibly has not the property of thermosensitive gelation. The hydrogel composition material has the effect of wound surface adhesion prevention after the hydrogel composition material is coated on the postoperative wound surface.

The invention discloses a skin model and application. The method comprises separately culturing epidermal cells and dermal cells derived from fetus scalp, newborn prepuce or adult scalp, and subculturing, wherein the used culture medium and culture method can maintain multiple functions of skin cells; separately digesting the cultured and proliferated multifunctional epidermal cells and dermal cells into single cells, and mixing to obtain suspension; transferring onto a semipermeable polymer or silica gel membrane substrate for incubation; transplanting cells on adhesive film to a receptor. The method can regenerate human intact functional skin and hair, the regenerated skin contains an epidermal layer, a dermal layer and a subcutaneous tissue as well as skin appendant organs. The skin model regenerated by the method disclosed by the invention can be used for study of human skin diseases, screening of skin drugs, and development of cell products for treating wound and other skin diseases.

The present invention is directed to novel drug compositions and dosage forms comprising said drug compositions. The drug compositions of the present invention comprise a pharmaceutical agent and a solubilizing agent. The drug compositions of the present invention are particularly advantageous for use with low solubility and/or low dissolution rate pharmaceutical agents. The present invention is further directed to methods for manufacturing of said drug compositions and dosage forms. The present invention is further directed to methods of treatment comprising administration of said drug compositions and dosage forms. The present invention further provides topiramate drug compositions, dosage forms and methods of treatment which provide a reduction in the frequency and/or severity of at least one adverse event associated with topiramate treatment.

Immunostimulatory compounds can be extracted from microalgae or algae using various procedures. The resulting preparations exhibit extremely potent immunostimulatory activity. The extraction of these immunostimulatory agents is dependent on the solvent used and the extraction temperature. These preparations are potentially useful as a botanical or pharmaceutical preparation to improve immune function.

Agents that inhibit or prevent restenosis are identified by assaying test agents in a battery of assays to measure the effect of the test agent on cell proliferation, thrombosis, tissue modeling, and inflammation. Treatment for restenosis is provided using compositions of the invention.

The invention relates to sutures and in particular relates to a method for preparing an absorbable suture. The method for preparing the absorbable suture disclosed by the invention comprises the following steps: (1) separating protein chorion; (2) purifying collagen fibers; (3) deoiling and degreasing; (4) inactivating viruses; (5) performing chrome tanning; (6) performing crosslinking dehydration; (7) polishing; (8) performing chitosan atomization; and (9) packaging. The absorbable suture prepared by the method disclosed by the invention has the characteristics of high tensile strength, knotting firmness, high biocompatibility and small toxic and side effects, and the suture can be absorbed by the body. The suture is completely absorbed, an absorption reaction is avoided, the suture does not need to be taken out, the tissue compatibility is high, and an adverse reaction in the human body is avoided regardless of the time; and moreover, the surface is smooth, the suture is difficultly infected by germs, and infection can be avoided.

Preparation for wound healing and prevention of adhesion to the wound containing a physiologically acceptable salt of hyaluronic acid, iodine and potassium iodine.

The invention provides a wound spray for treating bruises. The wound spray is composed of effect ingredients and a blank film formation stock solution, the effect ingredient are selected from one or more of external use disinfectants, external use antibiotics, local anesthetic and skin astringing ingredients, the blank film formation stock solution comprises polyvinyl butyral, a film formation auxiliary, a plastification viscosity-regulation agent, a surface active agent, a volatilization-assisted antisticking agent, a porogen, an aromatic and a solvent. The wound spray has the advantages that the film formation auxiliary is added so that formed films are more elastic; by means of the plastification viscosity-regulation agent, the regulated viscosity of the formed films is more suitable; by means of the volatilization-assisted antisticking agent, the volatilization of the stock solution is accelerated, and a spray valve is prevented from being blocked; and by means of combined actions of the ingredients, the wound spray is good in bactericidal effects and bioadhesive performances and capable of accelerating wound healing, ventilating wounds, preventing bacteria, inhibiting the bacteria and wetting the wounds.

The invention relates to the field of medicinal dressings and in particular relates to a multifunctional liquid dressing and a preparation method thereof. The multifunctional liquid dressing comprises the following components in parts by mass: 2-8 parts of polyvinyl butyral, 0.5-0.8 part of sodium alginate-polyvinylpyrrolidone, 0.2-0.6 part of nano-silver-chitosan, 0.1-0.4 part of sodium carboxymethylcellulose, 0.1-0.4 part of carrageenan, 0.1-0.4 part of menthol and 91-97 parts of absolute ethyl alcohol. The multifunctional liquid dressing disclosed by the invention is waterproof, breathable and visible in wound, can prevent infection and contributes to wound healing.

The invention belongs to the field of medicinal dressings, and particularly relates to a magnetically therapeutic antibacterial haemostatic wound dressing and a preparation method thereof. The magnetically therapeutic antibacterial haemostatic wound dressing is prepared from the following components in parts by weight: 0.5-4 parts of alginate, 0.5-6 parts of chitosan, 0.5-4 parts of a crosslinking agent, 0.1-2 parts of permanent magnetic nano-particles, 0.5-4 parts of nano-silicon dioxide and 0.005-0.5 part of growth factors. The magnetically therapeutic antibacterial haemostatic wound dressing can be used for quickly stopping bleeding, inhibiting bacteria, diminishing inflammation and promoting healing of a wound, is simple in preparation process, and is good in stability and convenient to carry.

A Hydrophilic polyurethane provided by the invention is made: a first polyether polyol and the polyisocyanates are acted, the second polyether polyol and transparent hyaluronic acid are acted to obtain star-shaped block polyurethane. The first polyether polyol includes at least three polyether polyols. The present invention further provides a hydrophilic polyurethane foaming body made by the hydrophilic polyurethane ad the foaming body, and the holes are non-continuous sealing holes. The present invention further provides wet-type wound dressing comprising a sheet absorbed layer which has the materials of the hydrophilic polyurethane or the hydrophilic polyurethane foaming body. The wet-type wound dressing can make the wound wet and prompt the wound cure and can effectively absorb the wound liquid.

The invention provides liquid band-aid and a preparing method thereof.The liquid band-aid comprises, by mass, 0%-10% of propolis, 1%-20% of film-forming materials, 5%-9% of castor oil, 4%-8% of lemon volatile oil, 30%-60% of diethyl ether, 3%-8% of ethyl acetate, 1%-23% of benzyl alcohol and 2%-15% of isopropyl alcohol.The liquid band-aid is easy and convenient to use, and is not limited by the size and the positions of wounds, a film can be rapidly formed after coating, and the wet and aseptic physical environment is provided for the wounds; meanwhile, active ingredients such as propolis are released, wound healing is promoted, and healing time is shortened.

The invention relates to a preparation method of a silver ion antibacterial medical dressing, and the preparation method comprises the following steps: dyeing, attaching a silver ion antibacterial agent, baking, mixing with viscose, weaving, slitting peritoneum, and preparing patch. Compared with similar products, the product has stronger infection resistance, can be used for remarkably accelerating wound healing, shortening the course of treatment and reducing the formation of scars. Clinical application proves that the silver ion antibacterial medical dressing is applicable to treatment of I-type, II-type and III-type cuts after an operation, has the advantages of safety, reliability, efficiency, no allergy occurrence and the like, and is suitable for clinical popularization and application.

The invention provides a wound cleaning liquid, which comprises an active component, an osmotic pressure regulator and deionized water; the active component is one or more from a wormwood extract, an aloe extract and a mint extract. The wound cleaning liquid provided by the invention has no stimulation to a wound, can clean the wound, also has bactericidal, anti-inflammatory, analgesic, and wound healing promoting effects, and scars are not easy to leave.

This invention discloses chemically modified polyaminosaccharides, in particular chemically modified chitosans, in the molecular structure of which a predetermined proportion of the amino functional groups is sulfonated by the hydrocarbyl sultone compound via a covalent bond. Such chemically modified polyaminosaccharides may be produced by a process of sulfonating an un-modified polyaminosaccharide having amino functional groups by a hydrocarbyl sultone compound in the presence of an organic solvent under a suitable temperature. Chemically modified chitosans of this invention may be used in a variety of applications, including wound healing.

The invention discloses a scar rehabilitating solution and a preparation method thereof. The preparation method comprises: (1) adding rhubarb and pseudo-ginseng root, which are raw materials, into water solution of ethanol, heating performing reflux extraction to obtain extract solution, and concentrating under reduced pressure; (2) decocting trogopterus dung serving as a raw material in water and concentrating the decoction under reduced pressure; and (3) mixing the concentrated solution obtained by the step (1) and the concentrated solution obtained by the step (2), uniformly mixing, addinghydroxypropyltrimethyl ammonium chloride chitosan or carboxymethyl chitosan in an amount which is 1 to 10 percent based on the total mass of the concentrated solution, uniformly stirring, adding a film forming agent in an amount which is 1 to 3 percent based on the total mass of the concentrated solution, uniformly stirring, and thus obtaining the scar rehabilitating solution. The scar rehabilitating solution provided by the invention has double effects of promoting heal of wound and reducing scar and has excellent rehabilitating effect on formed scar.

The invention provides a preparation method of a skin ulcer repairing matrix. According to the preparation method, a natural extracellular matrix subjected to decellularization, antigen removal and thickening treatment is adopted as a biological scaffold, seed cells are stratified on the surface of the natural extracellular matrix to form a cell membrane with multi-layer cells, and the skin ulcer repairing matrix is obtained after freeze drying treatment. By adopting the preparation method, the effects of surface cell stratifying of the extracellular matrix and partial cell ingrowth in the extracellular matrix are achieved; after the skin ulcer repairing matrix is used, the wound repairing can be effectively protected and promoted, and little scar is formed; the skin ulcer repairing matrix is short in preparation period, simple in process, suitable for industrialization, wide in application range, and good in wound repairing effect; the elasticity and toughness of the healed wound are close to those of the normal skin. By adopting freeze drying sterilization treatment, the product is guaranteed to have the expected use effect, the quality guarantee period is prolonged, and the transportation and storage requirements are reduced greatly.

The invention discloses wound dressing. The wound dressing is prepared by mixing medicinal hot melt adhesive and sodium carboxymethyl cellulose. The wound dressing has the advantages of protecting a wound, preventing bacteria from entering the wound, absorbing wound exudation, allowing the wound to produce gel, creating a wet environment to accelerate wound healing, facilitating stripping from the wound, preventing a patient from feeling great pain, preventing skin injury and necrosis on an apophysis position of a body caused by long-term friction and extrusion and performing autolytic debridement.

The invention discloses a preparation method of a silver-loaded meso-porous silicon/collagen/polyvinyl acetal antimicrobial dressing. The method comprises the following steps: vibrating meso-porous silicon in a silver nitrate solution to obtain silver-loaded meso-porous silicon; preparing a collagen solution, and mixing the silver-loaded meso-porous silicon with the collagen solution to obtain a silver-loaded meso-porous silicon/collagen blend solution; dissolving polyvinyl alcohol into boiling water, cooling, mixing with the silver-loaded meso-porous silicon/collagen blend solution evenly, so as to obtain a silver-loaded meso-porous silicon/collagen/polyvinyl alcohol blend solution; dissolving polyvinyl alcohol, adding lauryl sodium sulfate, a formaldehyde solution and calcium carbonate, stirring, adding hydrochloric acid and stirring to obtain polyvinyl acetal; and adding a polyvinyl alcohol/silver-loaded meso-porous silicon/collagen blend solution, and solidifying to obtain the silver-loaded meso-porous silicon/collagen/polyvinyl acetal antimicrobial dressing. The medical dressing prepared by the method is long in silver ion release cycle, has effective antibacterial ability, simultaneously is capable of promoting wound healing, has good mechanical strength, air permeability, hygroscopic property and foaming ability, and can be applied to wound treatment.

The invention relates to a Chinese medicinal medicament for treating hemorrhoid and anal fistula, which is prepared from the following raw materials (by weight ratio): rhubarb horsetails 400-600g, pagodatree flower 400-600g, leech 150-250g. buthus martensi kirsch 50-150g, gallnut 50-150g, white alum 10-30g, notoginseng 50-150g, ampelopsis root 50-150g, licorice root 50-150g.

The invention provides a convenient sealing agent for fibrin. It is made up of fibrin source 60-100 mg/ml, factor XIII (FXIII) 30-60 U/ml, thrombin 200-600 IU/ml and the buffer, the PH value is 6-8. the invention has rheology character, and strong adhesive ability, imitates the final period of physical cruor mechanism. It exerts functions of biological hemostasis, promotes the concrescence of wound, prevents organism conglutination, conglutinates viscera gap, seals lacuna organism in order to decrease the exudation, medicine releasing carrier slowly. It applies to all the modern surgical.

The invention discloses an anti-inflammatory and anti-allergic toothpaste. The toothpaste is prepared from, by weight percentage, 2-8% of chitosan oligosaccharide, 0.6-5% of a pinellia tuber extract,0.5-1.2% of a cortex llicis rotundae extract, 0.4-6% of a rhizoma cimicifugae extract, 20-30% of a humectant, 40-50% of an abradant, 0.6-2% of a thickener, 1.5-2.5% of a surfactant, 0.1-0.5% of a sweetening agent, 0.1-0.5% of a preservative, 1-1.5% of essence and the balance deionized water, wherein the total weight percentage is counted as 100%. The invention also provides a preparation method ofthe Chinese medicinal toothpaste. By means of a compounding technology, the toothpaste has the effects of relieving gingival periodontitis symptoms such as inflammation and bleeding while the original functions of cleaning the oral cavity and refreshing the breath are achieved by the toothpaste, the effects of preventing and treating dental ulcer, toothache and tooth sensitivity are achieved, thetoothpaste is used for alleviating the stimulation caused by cold, heat, sourness and sweet from the outside to the teeth, the environment of the oral cavity is gently nursed without damaging the teeth, the components are safe and effective, and a broad application prospect is obtained.

The invention provides a traditional Chinese medicine preparation for treating burn and scald and a preparation method thereof. The traditional Chinese medicine preparation of the invention comprises the following components: 80-120 parts by weight of calcined calamine, 80-120 parts by weight of calcined plaster, 80-120 parts by weight of calcined nacre mother, 40-60 parts by weight of dried alum, 15-30 parts by weight of processed frankincense, and 15-30 parts by weight of stir-fried myrrh. The traditional Chinese medicine preparation for treating burn and scald of the invention has the characteristics of rapid decrustation, wound swelling elimination, no residual scars, and the like during burn and scald treatment, and has extremely high medical medicinal value for burn and scald treatment.

The invention discloses a method for treating wounds of fruit trees. Hydrophilic or water absorbent material into which water-retaining agent is added serves as a carrier dressing, chemical liquid containing sterilization and wound healing promotion substances is added, the chemical liquid contains, by mass, 0.4% of ethylicin and a mixture of 200ppm of cytokinin beta-cyclodextrin inclusion compound and 70ppm of naphthylacetic acid beta-cyclodextrin inclusion compound, when the chemical liquid is used, a proper size of carrier dressing is cut out of the carrier dressing adsorbing the chemical liquid in a saturated mode to be applied to the surface of a wound, and then the wound is bounded and sealed with a plastic film. The method has the advantages that sterile proper-moisture environmental conditions capable of stimulating cells around the wounds to generate callus fast are provided for the wounds of the fruit trees, the callus will not root, and the wound healing rate is high; after the water-retaining agent is added, the carrier dressing loses water slowly, and long-term moisture preservation can be achieved in combination with replenishment of outside rainwater through fine and dense holes in the surfaces of the trees. The method for treating wounds of fruit trees is good in effect and high in wound healing rate, and the healing time can be shortened by 20 days compared with a conventional method under the same conditions.

The present invention relates to a collagen-silk fibroin co-assembled sponge material, co-assembled artificial skin and a preparation method thereof. The collagen-silk fibroin co-assembled sponge material has an ordered porous spatial structure and is prepared from a collagen-silk fibroin co-assembled product obtained by co-assembly of collagen and silk fibroin. The co-assembled artificial skin comprises a collagen-silk fibroin co-assembled sponge dermis and an epidermis. The dermis of the co-assembled artificial skin provided in the present invention is similar to the natural extracellular matrix in composition and structure. This kind of ordered novel structure can induce ordered arrangement and regeneration of cells, thereby promoting wound healing, reducing scar formation and achieving good biocompatibility.

The invention provides a medical foam dressing and a preparation method thereof. The medical foam dressing comprises base cloth, a colloid layer and a peeling-off layer, wherein the colloid layer is arranged on the base cloth, the peeling-off layer is arranged on the colloid layer, and the colloid layer comprises alginate, polyurethane foam, gelatin, carboxymethyl chitosan, carboxymethyl cellulose sodium, rosin resin, kaolin and vegetable oil. The preparation method comprises the following steps: melting the polyurethane foam, the rosin resin and the vegetable oil in a reaction kettle, adding the rosin resin after the polyurethane foam, the rosin resin and the vegetable oil are completely melted, and performing heat preservation; uniformly mixing the alginate, the gelatin, carboxymethyl chitosan, carboxymethyl cellulose sodium and kaolin, slowly adding the alginate, gelatin, the carboxymethyl chitosan, carboxymethyl cellulose sodium and kaolin which are uniformly mixed to the reaction kettle, after uniformly mixing, lowering the temperature, and defoaming; uniformly coating mixtures to the base cloth, lowering the temperature, and covering the peeling-off layer on the coated colloid layer so as to obtain the medical foam dressing. The medical foam dressing disclosed by the invention has favorable mechanical and physical properties, the preparation technology is simple, the cost is low, and the industrialization is easy to realize.

Methods and compounds are disclosed for wound healing by modulating autophagy. A formulation for modulating autophagy comprises a first modulating compound (FAM) selected from compounds having the general structure (I):

The invention relates to the field of hydrogel, and discloses a composite hydrogel as well as a preparation method and an application thereof. The composite hydrogel is formed by cross-linking polysaccharides and nanoparticles in an aqueous medium, wherein the nanoparticles are nano silicon dioxide, nano-hydroxyapatite, particles containing the nano silicon dioxide or particles containing the nano-hydroxyapatite. The composite hydrogel, which takes the nanoparticles as physical cross-linking points, can a non-covalent bond effect with chain segments of the polysaccharides, so that cross-linking with the chain segments of the polysaccharides is realized. Experimental results show that the composite hydrogel, by mixing the nanoparticles, is relatively good in effects of promoting cell proliferation and accelerating wound healing. Moreover, the composite hydrogel provided by the invention can be generated under gentle conditions; and the preparation method is simple.