33results about How to "Promote wound healing" patented technology

The present application belongs to the technical field of oral care, and particularly relates to an oral care composition and a preparation method thereof. The oral care composition comprises, by mass percentage, chitosan oligosaccharide 0.1-0.3%, sea hao polysaccharide 0.08-0.14%, forskolin 0.07-0.12%, corn sprout extract 0.05-0.09%, thickening agent 1-3%, humectant 40-50%, and the balance being water. The oral care composition of the present application can effectively inhibit the activity of glucosyltransferase, inhibit the production of dextran, interfere with the formation process of dental plaque, and reduce the adhesion sites of pathogenic bacteria in the oral cavity. In addition, the composition of the present application can promote the proliferation and repair of oral mucosa epithelial cells, and help repair oral mucosa damage. Furthermore, the use of each component in the composition of the present application can balance the oral microbial flora, while achieving the effect of inhibiting pathogenic bacteria and improving the oral environment.

This utility model discloses a low-temperature high-frequency surgical scalpel, comprising: a handheld part; and a scalpel head body mounted on the handheld part. The handheld part is used to connect a power source, enabling the scalpel head body to perform high-frequency cutting. The scalpel head body includes a blade surface and a cutting edge, with the cutting edge surrounding the blade surface and having a beveled structure. The surface of the blade surface is coated with an insulating coating. This allows for low-temperature, high-efficiency cutting, reducing thermal damage to tissues.

The application discloses a kind of Ampelomyces quisqualis rice fermentation extraction compound and preparation method and application thereof, its preparation method is: preparation Ampelomyces quisqualis seed liquid;Preparation rice fermentation medium, Ampelomyces quisqualis seed liquid is used to ferment medium, under 22±2 ℃, natural fermentation 5~60 days, after drying, fermentation dry material is obtained for future use;After sieving, fermentation dry material is crushed and added with water, after heating reflux, centrifugation and filtration supernatant, Ampelomyces quisqualis rice fermentation extract is obtained;Hyaluronic acid or sodium hyaluronate is added to Ampelomyces quisqualis rice fermentation extract, and the compound is obtained after swelling and drying.The application is formed by Ampelomyces quisqualis rice fermentation extract and hyaluronic acid (sodium), and the polymer grid can be synergized and quickly anti-inflammatory and promote wound healing, especially promote the regeneration of normal skin appendages such as hair follicle to heal, effectively improve the repair and cure effect on various skin and mucosa damage, and has no negative effect.

The application discloses a salicylic acid-cyclodextrin-amino acid ternary inclusion compound and a preparation method thereof. The salicylic acid-cyclodextrin-amino acid ternary inclusion compound is formed by non-covalent bond interaction of salicylic acid, amino acid and cyclodextrin derivatives, wherein the cyclodextrin derivative is a cross-linked beta-cyclodextrin polymer, wherein the salicylic acid molecules are included in the cavity of the cross-linked beta-cyclodextrin polymer, and meanwhile, the guanidino group or carboxyl group of the amino acid side chain interacts with the hydroxyl group outside the cross-linked beta-cyclodextrin polymer or the exposed part of the salicylic acid molecules after inclusion. The application uses the cross-linked beta-cyclodextrin polymer and introduces arginine as a synergist to construct a salicylic acid-cross-linked beta-cyclodextrin polymer-arginine ternary inclusion compound, and through charge neutralization and hydrogen bond network synergistic effect, the inclusion efficiency is significantly improved, and the water solubility of salicylic acid is improved.

This invention provides a liquid crystal biomimetic water-locking and oxygen-permeable skincare composition, its preparation method, and its application, belonging to the field of cosmetic technology. It comprises the following components by weight percentage: 20-40% glycerin, 5-10% hydrogenated lecithin, 5-10% phytosterols, 0.1-0.5% sodium stearoyl glutamate, 0.01-0.05% sodium methylstearoyl taurate, 0.1-1% ceramide NP, 1-10% caprylic / capric triglyceride, 1-10% squalane, 0.1-1% tocopheryl acetate, 0.01-0.3% sodium DNA, 0.001-0.1% fibronectin, 0.001-0.1% soluble collagen, and the balance being water. The liquid crystal biomimetic water-locking and oxygen-permeable skincare composition provided by this invention can better form a breathable protective film on the skin surface, reduce skin moisture loss, and help repair damaged skin barriers, thereby achieving the effect of water-locking and oxygen-permeable skincare.

The invention discloses a hydrogel dressing containing pearl sac liquid as well as a preparation method and application of the hydrogel dressing, and belongs to the technical field of medical dressings. The hydrogel dressing is prepared by taking polyvinyl alcohol (PVA) and chitosan (CS) as gel matrixes and loading Markov pearl sac liquid through an in-situ crosslinking technology. The hydrogel dressing is of a three-dimensional porous network structure and is excellent in water absorption performance, the mechanical property of the hydrogel dressing meets the wound repairing requirement, the bacteriostasis rate of the hydrogel dressing on common burn pathogenic bacteria such as staphylococcus aureus and pseudomonas aeruginosa exceeds 90%, and the hydrogel dressing is free of obvious cytotoxicity. When being applied to burn infection wounds, the medical dressing can effectively inhibit bacterial proliferation of the wounds, relieve inflammatory response, promote angiogenesis and tissue regeneration and remarkably improve the closure rate of the wounds, solves the problems that existing burn dressings are narrow in antibacterial spectrum, limited in repair promoting capacity and the like, provides a safe and effective novel dressing choice for clinical treatment of burn infection, and has wide application prospects. Meanwhile, the effective utilization of the martensitic pearl sac liquid is realized.

This application provides a composite wound dressing and its preparation method, belonging to the field of medical dressing technology. The composite wound dressing includes an outer support layer and an inner functional layer. The outer support layer is a modified ramie fiber nonwoven fabric, the modification including low-temperature plasma treatment and acetylation modification of the ramie fibers. The inner functional layer is a composite of ramie woven fabric and low-antigen collagen sponge grafted with carvacrol. The collagen sponge penetrates the yarn gaps and pores of the woven fabric, forming a structure in which the collagen sponge and ramie fibers mutually wrap and interweave. The dual-layer structure design of the dressing, with its outer support layer and inner functional layer, provides stable mechanical support through the outer layer to maintain the dressing's shape, while the inner layer enables efficient absorption of exudate and sustained release of antibacterial components, actively promoting wound healing. It exhibits excellent biocompatibility and low immunogenicity risk.

The application discloses a traditional Chinese medicine composition for repairing a wound, a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition has the effects of clearing heat and resolving toxins, eliminating swelling and removing blood stasis, and has the effects of immune regulation and anti-fibrosis, so that the traditional Chinese medicine composition has the effects of dissipating blood stasis and eliminating muscle nodules in the process of repairing the wound. The traditional Chinese medicine composition also has the effects of reducing swelling and relieving pain. The traditional Chinese medicine composition has the effects of stopping bleeding and relieving pain. The traditional Chinese medicine composition has the effects of promoting cell differentiation and promoting muscle regeneration. The traditional Chinese medicine composition has the effects of promoting blood circulation and the traditional Chinese medicine composition has the effects of promoting muscle regeneration. The traditional Chinese medicine composition has the effects of preventing inflammation and scars and promoting wound healing through specific combinations and synergistic effects according to monarchs, ministers, and assistants.

The application discloses a kind of monitor and monitoring method based on painless saliva dynamic monitoring patient blood glucose belonging to blood glucose monitor technical field, including monitor body, the top of monitor body is equipped with monitoring groove, the inside of monitoring groove is equipped with biosensor, the end of biosensor is equipped with conical needle, the inside of monitoring groove is equipped with saliva pipe, the top of one end of saliva pipe is equipped with sampling tube, one end of saliva pipe is equipped with plug, the inboard of plug is equipped with rubber sealing layer, the inside of the end of saliva pipe away from plug is equipped with piston, the side of piston is equipped with push rod, by using the principle of injector, provide certain suction, to improve the convenience of sampling, cooperate rubber sealing layer and the conical needle of the end of biosensor, to realize that biosensor is inserted into the inside of saliva pipe, to realize the purpose of monitoring, compared with traditional sampler, effectively avoid saliva in external environment excessively, cause saliva sample to be contaminated.

The invention discloses medical amorphous hydrogel and a preparation method thereof, and relates to the technical field of medical amorphous hydrogel, and the medical amorphous hydrogel is prepared from the following components by mass: 0.2-3% of a gel matrix; 0.1%-0.8% of a thickening agent; 0.8%-5% of a humectant; 0.01%-0.4% of a preservative; 0.2%-0.5% of a neutralizing agent; and the balance of purified water. The amorphous hydrogel provided by the invention can be tightly attached to a burn wound surface, not only can be used for moistening the wound surface and efficiently absorbing or discharging wound surface seepage, but also can be used for absorbing wound surface energy so as to relieve pain and cool skin, and meanwhile, air pollution protection is realized by virtue of a base material, so that an excellent environment is provided for healing of the burn wound surface.

The application discloses a silk fiber-based anti-bedsores decompression pad and a preparation method thereof, which comprises a fabric layer in a concave shape, an aerogel layer and a fiber layer are arranged in the fabric layer from bottom to top, the total height of the aerogel layer and the fiber layer after being stacked is equal to the depth of the fabric layer, the fiber layer is prepared from drug-loaded hydrophobically modified sodium alginate fiber, and the aerogel layer is prepared from degummed silk-sodium alginate composite aerogel with a three-dimensional porous structure. The decompression pad has antibacterial and healing promotion effects, the silk fiber enhances the physical and mechanical properties of the aerogel layer, can greatly reduce external pressure, has excellent air permeation effect due to the through-hole structure in the interior, can fully and quickly absorb wound exudates, the sodium alginate-based material also provides a suitable microenvironment for cell growth, accelerates wound healing, and is suitable for the prevention and treatment of bedsores of patients who need to be in bed for a long time.

The application belongs to the technical field of medical nutritional foods, and particularly relates to a composite peptide nutritional composition for promoting wound healing and a preparation process and application thereof. The composite peptide nutritional composition for promoting wound healing is prepared from raw materials including fish collagen peptide 15%-25%, bovine spleen peptide 0.03%-0.05%, blood protein oligopeptide 0.10%-0.30%, albumin peptide 0.10%-0.30%, ginseng powder 0.01%-0.03%, composite fermentation extract 15%-20%, plant extract 10%-20%, prebiotic 20%-25%, and whey protein matrix supplementing the rest to 100% by weight percentage. The application improves the content of healing-promoting peptide segments and various active ingredients such as anti-inflammatory repair by using self-made fish collagen peptide, composite fermentation extract and other raw materials, and improves the bioavailability of plant extract through embedding technology, thereby significantly improving the wound healing rate and quality.

The application discloses a kind of polypeptide, polypeptide extraction and purification method with river toad as raw material and application thereof, belong to the field of bioactive peptide, its amino acid sequence is FPGGPGAK, and preparation method and application in the field of cosmetics are also disclosed.The polypeptide disclosed in the application, polypeptide extraction and purification method with river toad as raw material and application thereof are extracted, purified and screened by treating river toad skin, and the central peptide segment playing a photoprotection role is used in cosmetics.

This invention relates to a cosmetic composition containing camellia callus-derived exosomes as an active ingredient, which has anti-inflammatory, antioxidant, whitening, anti-wrinkle, moisturizing, skin regeneration, skin barrier improvement, atopic dermatitis improvement, and skin soothing effects. The camellia callus-derived exosomes provided by this invention, as a cosmetic or pharmaceutical composition for anti-inflammatory, atopic dermatitis improvement, wound healing, and wound healing promotion, exhibit excellent effects.

The application discloses application of Neuritin in preparation of a medicine for promoting healing of a diabetic wound. The application proves for the first time through experiments that Neuritin expression in wound edge tissue and surrounding sensory neurons is significantly up-regulated after skin damage, and Neuritin expression is significantly down-regulated under a diabetic condition. By constructing a nervous system conditional knock-out and a sensory neuron specific knock-out Neuritin mouse, it is proved that wound healing is significantly delayed after Neuritin is knocked out. By means of spinal cord site injection of an AAV virus to overexpress Neuritin in a DRG and skin electroporation technology to locally overexpress Neuritin in the skin, it is proved that overexpression of Neuritin can significantly promote wound healing of type 1 and type 2 diabetic mice. The application provides a brand-new target and strategy for treatment of a diabetic refractory wound, and has a good clinical transformation prospect.

The present disclosure relates to a conductive microneedle array with super-high silicon needles and a preparation method thereof, characterized in that the microneedle array comprises silicon needles and a silicon substrate integrally formed with the silicon needles, the silicon needles are arranged in an array form on the silicon substrate, the bottom diameter of the silicon needles is 150-900 μm, the height of the silicon needles is 450-1000 μm, the hardness of the silicon needles of the microneedle array is not less than 13 N, the bottom surface of the silicon substrate of the microneedle array is uniformly coated with a conductive film with a thickness of 10-200 nm, and the conductive film is made of a metal material or a conductive alloy material. The height of the silicon needles on the microneedle array of the present disclosure is much higher than that of ordinary microneedles, and a conductive film is coated, a micro-current is generated, drug absorption is facilitated, and the irritation to the skin is small.

The invention belongs to the technical field of plant propagation, and discloses a rare Chinese herbaceous peony bud grafting rapid propagation method, which comprises the following steps: (1) rootstock cultivation and selection, (2) planting box treatment, (3) bud grafting knife treatment, (4) bud scion collection and treatment, (5) bud grafting operation process, (6) management after bud grafting, and (7) bud grafting seedling field planting. According to the growth characteristics of the rare Chinese herbaceous peony, Chinese herbaceous peony bud grafting is adopted for rapid propagation, the cultivation method is optimized, and rapid popularization of high-quality varieties is improved. Meanwhile, a stock selection and cultivation method is optimized, local peony seedlings are selected as stocks, affinity is good, stress resistance is high, and a good foundation is provided for bud scion healing and growth; meanwhile, through normative matrix proportion and cultivation management, it is ensured that the stock grows robustly, and the budding survival rate is increased.

The application belongs to the field of biomedical polymer materials and regenerative medicine, and particularly relates to an intelligent hydrogel for treating skin tissue damage, a preparation method and a medicine thereof, and application thereof. The intelligent hydrogel comprises a hydrogel support and a functional module. The hydrogel support takes methacrylated gelatin as a matrix and forms a stable three-dimensional network structure through photo-crosslinking. The functional module comprises two core DNA chains, one of which is a ZnR-Cage chain with a sulfhydryl group directly or indirectly connected to one end of the chain, and the other is a CD44-link chain. The two chains form a non-active assembly through base complementary pairing. The intelligent hydrogel has many advantages such as strong spatiotemporal controllability, overcoming drug burst defects, efficient cascade repair, realizing targeted synergistic treatment, efficient integration, excellent stability and clinical transformation potential. It is particularly suitable for clinical treatment of complex wounds such as diabetic ulcers and infected wounds.

This application provides a self-generating nano-silver PVDF composite fiber, comprising polyvinylidene fluoride (PVDF) and nano-silver, which are combined via electrospinning. By introducing AgNPs into the piezoelectric material PVDF and fabricating it into micro-electric nanofibers using electrospinning, this fiber possesses both the long-lasting, broad-spectrum antibacterial properties of nano-silver and the ability to continuously generate microcurrents on the wound surface. It does not rely on external devices such as fixed power supplies and electrode pads required for commonly used clinical electrical stimulation, making it highly significant and effective in reducing post-burn / traumatic infection, promoting wound healing, and ensuring patient safety and timely recovery. This solves the problem of poor stability and environmental limitations of PVDF nanocomposite membranes, which negatively impact wound healing. This application also provides a method for preparing the self-generating nano-silver PVDF composite fiber and its application in preparing dressings for treating burns and wounds.

The invention discloses a sodium alginate-beta-glucan composite wound repair spray with rapid film forming and long-acting repair functions and a preparation method thereof. According to the preparation method, sodium alginate is subjected to low oxidation degree modification, so that the sodium alginate and hydroxypropyl methylcellulose with viscosity gradient regulated and controlled form a high-ion response composite system, the obtained spray can quickly form a film after being sprayed, and meanwhile, yeast beta-glucan is subjected to phosphorylation modification, so that the water solubility and the targeting property are improved; according to the present invention, the binding force with the macrophage receptor is enhanced, the anti-inflammatory efficiency is improved, and the ultrasonic-microwave synergistic swelling, gradient dropwise adding-dynamic shearing cross-linking and other methods are adopted during the preparation, such that the uniformity, the stability and the safety of the product are improved. The obtained spray has multiple effects of rapid film formation, mild bacteriostasis and long-acting repair, can break through vicious circle of chronic wound repair, and provides an innovative thought for development of wound nursing products.

This invention discloses a multifunctional medical repair ozone oil composition and its preparation method, belonging to the technical field of medical external care preparations. The composition uses 1%–60% ozonated oil and animal repair oils as its core components, and can selectively add petrolatum, vitamin E, chitosan, and natural plant fragrance essential oils. The surgical skin-specific formula can add peppermint and borneol to enhance penetration, while the gynecological formula is gentle and non-irritating. This product has multiple effects, including antibacterial and anti-inflammatory properties, antipruritic and analgesic effects, moisturizing and repairing properties, and promoting the healing of mucous membranes and skin wounds. It is suitable for gynecological intimate care, surgical skin repair, and can also be applied externally to the back to soothe respiratory discomfort and to the abdomen to relieve abdominal pain and bloating. It has a wide range of applications, high clinical value, and is suitable for large-scale production and clinical promotion.

The invention relates to a melanin-based silk fibroin microneedle and a preparation method thereof, and belongs to the technical field of microneedles. The preparation method comprises the following steps that S1, polymethacrylate serves as printing ink, and a resin microneedle male mold is prepared through a DLP 3D printing technology; s2, hydrophobizing the resin microneedle male mold, and drying to obtain a resin model; s3, a polydimethylsiloxane solution is poured into the resin model, and a polydimethylsiloxane microneedle mold is obtained through vacuumizing, drying and demolding treatment; s4, a needle body solution containing methacrylated silk fibroin, melanin and a photoinitiator is poured into the polydimethylsiloxane microneedle mold, and a needle body is formed through vacuum defoaming and curing crosslinking; then, a base solution containing polyvinyl alcohol is poured, a base is formed through standing, defoaming and drying, and the high-precision microneedle is obtained; the microneedle not only has certain antibacterial and anti-inflammatory effects, but also can promote drug delivery and wound recovery after drug loading.

The invention belongs to the technical field of self-assembled microsphere arrays, and particularly relates to a pore-adjustable and stable self-assembled microsphere array as well as a preparation method and application thereof. The microsphere array disclosed by the invention is self-assembled in a manner of combining electrostatic mediation and covalent coupling, and contact among the microspheres is guided by virtue of electrostatic interaction, so that guidance is provided for realizing controllable covalent coupling among the microspheres by virtue of Schiff base reaction. The combination of covalent coupling and electrostatic force can improve the flexibility of the microsphere array and the stability of the combination between the microspheres, so as to improve the stability of pores between the microspheres, reduce the collapse of the microsphere array, provide a good and controllable three-dimensional space for the creeping growth of cells, and facilitate the promotion of wound healing and growth. The self-assembled microsphere array is suitable for application modes such as smearing or injection, and the scene applicability is greatly improved.

The present application relates to a light and dark dual-mode regulation wound microenvironment material and its preparation method and application, and belongs to the technical field of biomedical functional materials. The chemical formula of the material is MoO 3‑x / Ho2O3 / N-C, MoO 3‑x / Ho2O3 nanoparticles are loaded, coated or embedded in a nitrogen-doped carbon skeleton, wherein 0<=x<=2. The present application also provides a preparation method of the material and its application in preparing treatment of infected diabetic wounds, chronic non-healing wounds, bacterial infection wounds, oxidative stress related tissue damage and vascular repair products. The light and dark dual-mode regulation wound microenvironment material provided by the present application has SOD-like and CAT-like nanoscale enzyme activity, can inhibit bacteria and kill bacteria, reduce oxidative damage, and protect fibroblasts, endothelial cells and macrophages. At the same time, it covers multiple pathological links such as bacterial infection, lactic acid accumulation, ROS excess, inflammation persistence and insufficient vascularization in infected diabetic wounds, and has more complete wound microenvironment regulation ability.

This invention belongs to the field of traditional Chinese medicine compound technology, and discloses a traditional Chinese medicine compound and mask preparation for anti-inflammatory, soothing and repairing facial dermatitis. The traditional Chinese medicine compound is made from the following traditional Chinese medicines in parts by weight: purslane: 10-15 parts, phellodendron bark: 10-12 parts, burnet root: 10-12 parts, and licorice root: 6-10 parts. This invention selects four medicinal materials—purslane, phellodendron bark, burnet root, and licorice root—and formulates them in a clear and coordinated manner. The herbs work synergistically, addressing both the symptoms and the root cause. It can clear heat and dampness, cool the blood and detoxify, and also has modern pharmacological activities such as anti-inflammatory and antibacterial effects, and promotes wound healing. It can effectively improve various skin lesions such as erythema, swelling, itching, and burning in facial dermatitis. Moreover, the medicine is mild, has low irritation, acts directly on the affected area, has a direct effect, and is highly safe.

The invention discloses a compound of a basic fibroblast growth factor and a metal organic framework, a pharmaceutical composition and application, and belongs to the technical field of wound healing drugs. The bFGF (at) ZPF-2 compound provided by the invention comprises a metal organic framework material ZPF-2 and bFGF loaded on the ZPF-2, the bFGF (at) MIL-53 (Al)-FA compound provided by the invention comprises a metal organic framework material MIL-53 (Al)-FA and bFGF loaded on the MIL-53 (Al)-FA. By constructing two compounds of bFGF-coated ZPF-2 and bFGF-coated MIL-53 (Al)-FA, efficient loading and activity protection of bFGF are realized, rapid effect taking and continuous release synergy can be realized in response to a wound surface microenvironment, the biocompatibility is good, the wound surface healing effect is remarkably improved, and the storage and transportation cost is reduced.

This invention discloses a method for preparing and applying right-handed molybdenum-doped carbon dots. The method involves using D-tartaric acid, ethylenediamine, and molybdenum salt as raw materials, followed by hydrothermal reaction, centrifugation, dialysis, and lyophilization to obtain D-Mo-CDs. These carbon quantum dots exhibit selective response to circularly polarized light; D-Mo-CDs are specifically activated under left-handed circularly polarized light irradiation, achieving a photothermal conversion efficiency of 51.2%, and possessing highly efficient reactive oxygen species generation capabilities, enabling photodynamic-photothermal synergistic antibacterial effects. This invention also discloses the application of these carbon quantum dots in the preparation of spatiotemporally precise antibacterial materials and in medical devices or dressings for treating bacterial infected wounds. This material exhibits high biocompatibility, significant in vitro antibacterial effects, and promotes wound healing in vivo, providing a novel integrated solution for the treatment of infected wounds.

The invention relates to the technical field of biological materials, in particular to a polydopamine coating as well as a preparation method and application thereof. According to the specific technical scheme, a dopamine solution and a hydrogen peroxide aqueous solution are mixed on the surface of a base material to be coated, and the polydopamine coating is generated. The prepared polydopamine coating can effectively improve the lower urinary symptoms such as pathological bladder mucous membrane barrier damage, erosion, bleeding, pain, frequent urination and urgent urination, mucous membrane repair is accelerated, and the life quality of a patient is improved. The technical scheme provided by the invention has a wide application prospect in the field of chemical cystitis treatment.

The invention provides a microneedle patch for closed-loop management of drug-resistant bacteria infected wounds of animals as well as a preparation method and application of the microneedle patch. According to the micro-needle patch, silk fibroin / hyaluronic acid composite hydrogel serves as a matrix, silver nanorods with specific local surface plasmon resonance (LSPR) characteristics are loaded, and wound pH real-time monitoring and near-infrared two-zone (NIR-II) photo-thermal sterilization functions based on surface enhanced Raman spectroscopy (SERS) can be achieved. The microneedle structure can penetrate into the deep layer of the wound, and precise delivery and treatment are achieved. According to the invention, monitoring and treatment are integrated, a closed-loop management system is formed, and the diagnosis and treatment efficiency and healing quality of wounds infected by drug-resistant bacteria of animals are remarkably improved. The patch has good wound pH monitoring ability, antibacterial effect and wound healing ability, and an efficient and safe solution is provided for treatment of drug-resistant bacteria wounds of animals.