35 results about "Bioburden" patented technology

Various implementations, systems and methods are disclosed for continuous, near real-time, hands-off sampling of airborne particulate matter, and qualification and / or quantification of biomolecules in the sample representative for biologic or microbial contamination. The systems and methods may utilize an electrostatic precipitator for sampling the matter; and a measurement assembly configured to illuminate, excite, or breakdown the sampled matter by electromagnetic radiation, and to detect a spectrum, or one or more wavelength bands of the scatter emitted by the sample. In an exemplary implementation, a sputter deposition process is employed to configure the sample for an enhanced plasmon resonance. The measurement data may be transferred via wireless communication means for cloud storage and signal processing.

To provide methods of reducing bioburden of a chromatography resin.SOLUTION: Provided herein are methods that include exposing a container including a composition including (i) a chromatography resin and (ii) a liquid including at least one alcohol to a dose of gamma-irradiation sufficient to reduce the bioburden of the container and the chromatography resin, where the at least one alcohol is present in an amount sufficient to ameliorate the loss of binding capacity of the chromatography resin after / upon exposure to the dose of gamma-irradiation. Also provided are: reduced bioburden chromatography columns including the reduced bioburden chromatography resin; compositions including a chromatography resin and a liquid including at least one alcohol; and methods of performing reduced bioburden column chromatography using one of these reduced bioburden chromatography columns.SELECTED DRAWING: Figure 1

This application proposes a method for preparing gradient-pore structured biochar for soil remediation microbial loading, relating to the field of biomass resource utilization technology. The preparation method includes: pyrolyzing biomass raw materials at high temperature and then cooling to obtain biochar embryos; dissolving surfactants in water to prepare an impregnation solution; impregnating the biochar embryos in the impregnation solution and drying to obtain a mesoporous template; dispersing starch in water, heating, and adding the mesoporous template while stirring, reacting, and then cooling, settling, and drying to obtain a macroporous template; and calcining the macroporous template under an inert atmosphere using a gradient heating process to obtain biochar with a gradient-pore structure. This application, through synergistic regulation of raw material composition, pretreatment process, and programmed pyrolysis activation process, achieves for the first time a continuous gradient distribution of pore size from the outside to the inside ("macropore → mesopore → micropore") within a single biochar particle, significantly improving its performance as a microbial carrier.

Abstract The invention relates to a perioperative cobotic system designed to monitor, assess, and manage bioburden in real-time within operating room environments during surgical procedures and turnover phases. The system includes a mobile base equipped with a drive mechanism for maneuverability, a camera to capture image data, an actuator for camera movement, and a biosensor for direct bioburden assessment. Abstract for direct bioburden assessment. 20 26 21 41 22 10 A ug 2 02 6 A b s t r a c t 2 0 2 6 2 1 4 1 2 2 1 0 2 0 2 6 A u g

The invention discloses an ammonia direct oxidation denitrification device for water body remediation and a composite microbial carrier. The composite microbial carrier comprises an acetone slow-release inner core and a biological load shell, the acetone slow-release inner core is composed of an acetone-loaded solid adsorbent core and a calcium alginate gel wrapping layer, and precise and long-acting slow release of acetone is achieved through cooperation of adsorption immobilization and a gel diffusion barrier; the biological load shell is composed of polyurethane foam with a three-dimensional communicated macroporous structure, the inner core is wrapped in the shell, and the shell provides a three-dimensional space for microorganism attachment growth and AMAO reaction and delays outward diffusion of acetone. The device comprises a modular remediation unit assembled by a plurality of composite microbial carriers, the modular remediation unit is added into the ammonia nitrogen polluted water body, ammonia nitrogen in the water body is directly oxidized into nitrogen by the AMAO functional flora, and in-situ continuous denitrification is realized. The method solves the problems that the carbon source is easy to diffuse and lose and microorganisms are difficult to colonize, and has the advantages of high remediation efficiency, lasting effect and environmental friendliness.

Abstract The invention relates to a perioperative cobotic system designed to monitor, assess, and manage bioburden in real-time within operating room environments during surgical procedures and turnover phases. The system includes a mobile base equipped with a drive mechanism for maneuverability, a camera to capture image data, an actuator for camera movement, and a biosensor for direct bioburden assessment. Abstract assessment. 20 26 20 16 37 04 M ar 2 02 6 A b s t r a c t 2 0 2 6 2 0 1 6 3 7 0 4 M a r 2 0 2 6 a s s e s s m e n t .

The present disclosure provides, among other things, methods of drying porcine thyroid gland material and manufacturing DTE comprising vacuum drying porcine thyroid gland material in a way such that the temperature of the porcine thyroid gland material is maintained above a threshold temperature. Since applying vacuum, or reducing pressure, has a cooling effect on the porcine thyroid gland material, maintaining the porcine thyroid gland material above a threshold temperature can be achieved by gradually reducing pressure while simultaneously increasing the heat applied to the porcine thyroid gland material during the period of gradual pressure change. Such methods are advantageous in reducing bioburden (killing and impeding the growth of microorganisms) while maintaining therapeutic levels of thyroid hormones, as compared to certain methods of drying porcine thyroid gland material and / or manufacturing DTE known in the art.

The invention discloses a method for treating acid mine wastewater by using composite biochar, and relates to the technical field of sewage treatment. The invention discloses a method for adsorbing acid mine wastewater by using composite charcoal. The preparation method of the composite biochar comprises the following steps: performing alternate layer deposition on the surface of Fe-Al bimetallic oxide modified biochar to construct a chitosan layer and a carboxymethyl cellulose layer to obtain modified biochar; adsorbing acidophilic thiobacillus ferrooxidans by using the modified biochar to obtain microorganism-loaded biochar; inducing a hydroxyapatite mineralized membrane on the surface of the microorganism-loaded biochar to obtain acid-resistant microorganism-loaded biochar; and finally, embedding and fixing the acid-resistant microorganism loaded biochar to obtain the composite biochar. The composite biochar prepared by the invention can stably treat acid mine wastewater for a long time, and is convenient to recycle.

The invention relates to a method for treating medical waste through cooperation of spectrums and steam, and belongs to the technical field of medical waste treatment. According to the treatment method, the medical waste is treated through the cooperation of ultraviolet rays, near infrared rays and steam, the microorganism inactivation rate of the pet medical waste can be remarkably increased, the degradation rate of amoxicillin can be increased, biological membranes and chemical pollutants on the surfaces of the sharp instruments can be effectively removed, and the biological loading capacity of the treated sharp instruments is smaller than or equal to 10 CFU / g; meanwhile, compared with a traditional high-temperature treatment method, the treatment method has the advantages that the treatment period is shortened, energy consumption is reduced, and the method is suitable for on-site treatment of medical waste.

The present application relates to the technical field of radiation sterilization dose management, and particularly relates to a medical instrument radiation sterilization dose dynamic optimization system based on biological load analysis. The present application firstly obtains sterilization resistance according to the quantity difference of various bacteria before and after sterilization in all batches in the historical working period, combined with the corresponding radiation dose; further obtains comprehensive vitality combined with the seasonal similarity between working periods; further obtains biological load consistency and classifies the historical batches according to the similar characteristics of the quantity of all similar bacteria before sterilization and the comprehensive vitality between any two batches; further selects a reference batch, obtains a more reasonable initial radiation dose of the current working period according to the biological load consistency of the reference batch and the first batch at present, combined with the corresponding sterilization record, reduces the interference of seasonal activity difference of bacteria, reduces the number of subsequent repeated verification and correction, and improves the sterilization efficiency.

Reductants may reduce microbial bioburden in protein solutions. Reducing bioburden can increase shelf life or ensure the safety of food or pharmaceutical products. The use of reductants to reduce bioburden in producing non-animal-based food products may also have additional advantages. For example, chroma and hue angle may be improved so that the non-animal-based food products may closely resemble the appearance of animal-based food products. Embodiments may include a method for forming a food product precursor. The method may include providing a first mixture. The first mixture may include a protein. The method may further include adding a reductant to the first mixture to form a second mixture. The method may also include heating the second mixture at a temperature for a duration to form a third mixture. The third mixture may be the food product precursor. Embodiments may include the food product precursor.

The invention provides a pulmonary tuberculosis drug respiration therapeutic apparatus for ICU treatment, and belongs to the technical field of pulmonary tuberculosis treatment. Comprising a base, an air compressor is fixedly installed at the top of the base, a treatment device is fixedly installed at the top of the air compressor, a disinfection device is fixedly installed on the side, away from the treatment device, of the top of the base, the treatment device comprises a top frame, and the top frame is fixedly installed at the top of the air compressor. Triple purification modules of mechanical scrubbing, atomization disinfection and ultraviolet irradiation are integrated, the inner wall of the breathing mask is mechanically scrubbed through the conical cleaning brush, and biological residues are flushed and removed in cooperation with the high-pressure water jet scalpel; surface microorganisms are disinfected and killed through alcohol atomization; finally, the inner surface and the outer surface of the mask are subjected to all-dimensional irradiation sterilization through the double ultraviolet lamp sets of the V-shaped connecting frame, the progressive disinfection process can effectively improve the disinfection capacity of the mask, and the biological load residual quantity is lower than the industrial standard limit value.

The present invention concerns methods for processing and / or purification of a biological product involving multi-angle light scattering as analytical tool for process control. The methods of the invention apply multi-angle light scattering to detect the biological product, the presence of a bioburden or the functionality and / or integrity of a consumable employed in the method for processing and / or purification of the biological product. Further, the invention relates to systems for processing and / or purification of a biological product configured to perform the methods of the invention. Lastly, the invention concerns computer program products which can be used in the methods of the invention.

Disclosed embodiments relate to apparatuses and methods for applying negative pressure to a tissue site or skin site to prepare for a surgical operation. The apparatuses and methods can be used to increase blood flow at or near the tissue site. Therapeutic gas can also be applied to prepare the tissue site for the operation. Antimicrobial and antiseptic agents can also be applied to reduce the bioburden at the tissue site.

The application discloses modified biological filler and a preparation method and application thereof in the field of denitrification removal of nitrate, and relates to the technical field of denitrification. The preparation method comprises the following steps: immersing polyurethane foam in an amination modification solution containing N-(2-aminoethyl)-3-aminopropyl trimethoxysilane to obtain amin-modified polyurethane foam; and then immersing the amin-modified polyurethane foam in a bacterial solution containing denitrification bacteria to obtain a biological-loaded polyurethane foam. The polyurethane foam with developed pores is used as a carrier, and the surface of the polyurethane foam is modified by N-(2-aminoethyl)-3-aminopropyl trimethoxysilane, so that the adsorption amount and the binding strength of the denitrification bacteria can be improved. The modified biological filler loaded with the denitrification bacteria can shorten the acclimation period in the denitrification equipment, improve the denitrification rate in the initial stage, and improve the removal efficiency of the nitrate in wastewater.

The disclosure is directed at methods for reducing the bioburden of both particles comprising an active pharmaceutical ingredient (API) and the equipment used to process such particles.

The present disclosure provides, among other things, methods of drying porcine thyroid gland material and manufacturing DTE comprising vacuum drying porcine thyroid gland material in a way such that the temperature of the porcine thyroid gland material is maintained above a threshold temperature. Since applying vacuum, or reducing pressure, has a cooling effect on the porcine thyroid gland material, maintaining the porcine thyroid gland material above a threshold temperature can be achieved by gradually reducing pressure while simultaneously increasing the heat applied to the porcine thyroid gland material during the period of gradual pressure change. Such methods are advantageous in reducing bioburden (killing and impeding the growth of microorganisms) while maintaining therapeutic levels of thyroid hormones, as compared to certain methods of drying porcine thyroid gland material and / or manufacturing DTE known in the art.

A bandage modulates the moisture level of a healing wound and includes sensors for detecting, collecting, and reporting data for various wound variables. The bandage may include an antimicrobial agent to reduce the bioburden of microorganisms within the bandage.

The invention belongs to the technical field of saline-alkali land treatment, and particularly relates to a comprehensive improvement method for soda saline-alkali land through cooperation of modified ardealite and microorganism loaded biochar. The method comprises the following steps: cleaning ardealite by using an acidic waste liquid containing organic acid to obtain modified ardealite; mixing the modified ardealite, the saline-alkaline tolerant microorganism loaded biochar and granular aggregate to prepare a composite filler; vertical holes drilled in soda saline-alkali soil in advance are filled with the composite filler, and a reaction type permeation column is constructed; water is supplied to the reaction type permeation column, calcium ions and microbial metabolites dissolved in the column are driven to laterally permeate towards peripheral soil, and sodium ions on soil colloid are replaced. According to the invention, through system integration of'material modification 'and'spatial reconstruction', an'in-situ vertical-horizontal coupled biochemical reactor 'is constructed, and the soda saline-alkali soil is effectively improved.

The present invention concerns methods for processing and / or purification of a biological product involving multi-angle light scattering as analytical tool for process control. The methods of the invention apply multi-angle light scattering to detect the biological product, the presence of a bioburden or the functionality and / or integrity of a consumable employed in the method for processing and / or purification of the biological product. Further, the invention relates to systems for processing and / or purification of a biological product configured to perform the methods of the invention. Lastly, the invention concerns computer program products which can be used in the methods of the invention.

The invention relates to the technical field of medical instruments for the ophthalmology department, and particularly discloses a preparation method of a biodegradable patch for sclera reinforcement after the ophthalmology department, and the preparation method comprises the following steps: pretreating an extracellular matrix; the method comprises the following steps: firstly, carrying out virus inactivation on tissues or organs derived from animals, and carrying out antigen removal and degreasing treatment to obtain a biological load-free extracellular matrix; the pretreated extracellular matrixes are stacked in multiple layers and placed in a mold, an upper plane clamping plate and a lower plane clamping plate are used for applying pressure for fixing, and the pressure ranges from 10 kpa to 200 kpa; and drying with a mold to obtain the biodegradable patch. The limit load of the biodegradable patch obtained by the preparation method provided by the invention is 31.7-70.6 N, the elongation at break is 254.9-567.3%, and the biodegradable patch can meet the requirements on material strength and long-term stability in a sclera reinforcement operation after ophthalmology.

The disclosure is directed at methods for reducing the bioburden of both particles comprising an active pharmaceutical ingredient (API) and the equipment used to process such particles. A method of applying a coating to particles comprising an API comprises: (a) loading the particles into a chamber; (b) applying a vaporous or gaseous metal or metalloid precursor to the particles in the reactor by pulsing the vaporous or gaseous aluminium precursor into the reactor; (c) performing one or more pump-purge cycles using an inert gas; (d) applying a vaporous or gaseous oxidant to the particles in the reactor by pulsing the oxidant into the reactor; (e) performing one or more pump-purge cycles using an inert gas; (f) repeating steps (a)-(e) at least once to provide a metal oxide or metalloid oxide coating layer on the particles; and a sterilization step before step (a), between step (a) and step (b), and / or after step (f).

The present invention relates to an apparatus and a process for handling an equipment-tray assembly. The present invention in particular concerns the fields of bioburden testing, water testing, pharmaceutical, cosmetics, food processing, semiconductor production, electronics, and environmental monitoring of closed processing areas.

Methods for disinfecting or sterilizing aptamer-based sensors in preparation for application to an animal subject. Irradiation, including e-beam irradiation at sterilizing doses, is found to result in sensors having useful sensitivity to a target analyte.

The present invention relates to an apparatus and a process for handling equipment tray assemblies. The present invention relates in particular to the fields of bioburden testing, water quality testing, pharmaceuticals, cosmetics, food processing, semiconductor manufacturing, electronic equipment, and environmental monitoring of closed processing areas.

One among various embodiments discloses a sealed nutrient cartridge for bioburden or sterility testing, comprising a transparent cover, a flexible side panel assembly coupled to the transparent cover, a transparent film assembly coupled to the flexible side panel providing a transparent film on an opposing side of the transparent cover, wherein the transparent cover, the flexible side panel assembly, and the transparent film assembly form an interior vessel for receiving a growth medium and a sample of a product.

The invention relates to a perioperative cobotic system designed to monitor, assess, and manage bioburden in real-time within operating room environments during surgical procedures and turnover phases. The system includes a mobile base equipped with a drive mechanism for maneuverability, a camera to capture image data, an actuator for camera movement, and a biosensor for direct bioburden assessment.

Bioburden analysis devices and related systems and methods are disclosed which utilize ultraviolet (UV) irradiation to enhance accuracy of results. A light source producing UV light is positioned along a passageway for a fluid flow upstream of a laser subsystem. The laser subsystem includes a laser which excites particulate within the fluid and a photo detector which measures fluorescence of the particulate within the fluid. By exposing the particulate to UV light prior to laser excitement, signal to noise ratio is increased, providing more accurate results.

The invention relates to the technical field of radiation sterilization dose management, in particular to a medical instrument radiation sterilization dose dynamic optimization system based on biological load analysis. The method comprises the following steps: firstly, obtaining sterilization resistance in a historical working period according to the quantity difference of various germs in all batches before and after sterilization and in combination with corresponding radiation doses; further combining seasonal similarity between the work cycles to obtain comprehensive vitality; further according to similar characteristics of the number and comprehensive vitality of all the similar germs between any two batches before sterilization, obtaining a biological load consistency degree, and classifying historical batches; a reference batch is further screened out, a more reasonable initial radiation dose of the current work period is obtained according to the biological load consistency of the reference batch and the current first batch in combination with a corresponding sterilization record, interference of seasonal activity difference of germs is reduced, the number of times of subsequent repeated verification and correction is reduced, and the sterilization efficiency is improved.

A treatment system, including a conveyor bed configured to transport a plurality of products; a brushing device located along the conveyor bed and having one or more brushes that include a first antimicrobial compound; a surface treatment device including a lamp configured to emit light of a peak wavelength directed toward a portion of the conveyor bed; and a coating device configured to deliver a coating mixture onto the plurality of products on the conveyor bed.