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12 results about "Bioburden" patented technology

Bioburden is normally defined as the number of bacteria living on a surface that has not been sterilized. The term is most often used in the context of bioburden testing, also known as microbial limit testing, which is performed on pharmaceutical products and medical products for quality control purposes. Products or components used in the pharmaceutical or medical field require control of microbial levels during processing and handling. Bioburden or microbial limit testing on these products proves that these requirements have been met. Bioburden testing for medical devices made or used in the USA is governed by Title 21 of the Code of Federal Regulations and worldwide by ISO 11737.

A preparation method of a gradient pore structure biochar for soil remediation microbial load

This application proposes a method for preparing gradient-pore structured biochar for soil remediation microbial loading, relating to the field of biomass resource utilization technology. The preparation method includes: pyrolyzing biomass raw materials at high temperature and then cooling to obtain biochar embryos; dissolving surfactants in water to prepare an impregnation solution; impregnating the biochar embryos in the impregnation solution and drying to obtain a mesoporous template; dispersing starch in water, heating, and adding the mesoporous template while stirring, reacting, and then cooling, settling, and drying to obtain a macroporous template; and calcining the macroporous template under an inert atmosphere using a gradient heating process to obtain biochar with a gradient-pore structure. This application, through synergistic regulation of raw material composition, pretreatment process, and programmed pyrolysis activation process, achieves for the first time a continuous gradient distribution of pore size from the outside to the inside ("macropore → mesopore → micropore") within a single biochar particle, significantly improving its performance as a microbial carrier.
Owner:CHINA MCC5 GROUP CORP LTD

Ammonia direct oxidation denitrification device for water body remediation and composite microbial carrier

The invention discloses an ammonia direct oxidation denitrification device for water body remediation and a composite microbial carrier. The composite microbial carrier comprises an acetone slow-release inner core and a biological load shell, the acetone slow-release inner core is composed of an acetone-loaded solid adsorbent core and a calcium alginate gel wrapping layer, and precise and long-acting slow release of acetone is achieved through cooperation of adsorption immobilization and a gel diffusion barrier; the biological load shell is composed of polyurethane foam with a three-dimensional communicated macroporous structure, the inner core is wrapped in the shell, and the shell provides a three-dimensional space for microorganism attachment growth and AMAO reaction and delays outward diffusion of acetone. The device comprises a modular remediation unit assembled by a plurality of composite microbial carriers, the modular remediation unit is added into the ammonia nitrogen polluted water body, ammonia nitrogen in the water body is directly oxidized into nitrogen by the AMAO functional flora, and in-situ continuous denitrification is realized. The method solves the problems that the carbon source is easy to diffuse and lose and microorganisms are difficult to colonize, and has the advantages of high remediation efficiency, lasting effect and environmental friendliness.
Owner:CHONGQING INST OF GREEN & INTELLIGENT TECH CHINESE ACAD OF SCI +1

Perioperative cobotic system for monitoring bioburden

Abstract The invention relates to a perioperative cobotic system designed to monitor, assess, and manage bioburden in real-time within operating room environments during surgical procedures and turnover phases. The system includes a mobile base equipped with a drive mechanism for maneuverability, a camera to capture image data, an actuator for camera movement, and a biosensor for direct bioburden assessment. Abstract assessment. 20 26 20 16 37 04 M ar 2 02 6 A b s t r a c t 2 0 2 6 2 0 1 6 3 7 0 4 M a r 2 0 2 6 a s s e s s m e n t .
Owner:PERITAS AI INC

Desiccated thyroid extract manufacturing method

The present disclosure provides, among other things, methods of drying porcine thyroid gland material and manufacturing DTE comprising vacuum drying porcine thyroid gland material in a way such that the temperature of the porcine thyroid gland material is maintained above a threshold temperature. Since applying vacuum, or reducing pressure, has a cooling effect on the porcine thyroid gland material, maintaining the porcine thyroid gland material above a threshold temperature can be achieved by gradually reducing pressure while simultaneously increasing the heat applied to the porcine thyroid gland material during the period of gradual pressure change. Such methods are advantageous in reducing bioburden (killing and impeding the growth of microorganisms) while maintaining therapeutic levels of thyroid hormones, as compared to certain methods of drying porcine thyroid gland material and / or manufacturing DTE known in the art.
Owner:AMERICAN LABORATORIES PHARMA LLC

System for dynamic optimization of radiation sterilization dose of medical devices based on biological load analysis

ActiveCN121096577BMedical data miningMedical equipmentProcess engineeringRadiation Sterilization
The present application relates to the technical field of radiation sterilization dose management, and particularly relates to a medical instrument radiation sterilization dose dynamic optimization system based on biological load analysis. The present application firstly obtains sterilization resistance according to the quantity difference of various bacteria before and after sterilization in all batches in the historical working period, combined with the corresponding radiation dose; further obtains comprehensive vitality combined with the seasonal similarity between working periods; further obtains biological load consistency and classifies the historical batches according to the similar characteristics of the quantity of all similar bacteria before sterilization and the comprehensive vitality between any two batches; further selects a reference batch, obtains a more reasonable initial radiation dose of the current working period according to the biological load consistency of the reference batch and the first batch at present, combined with the corresponding sterilization record, reduces the interference of seasonal activity difference of bacteria, reduces the number of subsequent repeated verification and correction, and improves the sterilization efficiency.
Owner:ZHONGJIN IRRADIATION

Negative pressure therapy systems and devices

Disclosed embodiments relate to apparatuses and methods for applying negative pressure to a tissue site or skin site to prepare for a surgical operation. The apparatuses and methods can be used to increase blood flow at or near the tissue site. Therapeutic gas can also be applied to prepare the tissue site for the operation. Antimicrobial and antiseptic agents can also be applied to reduce the bioburden at the tissue site.
Owner:T J SMITH & NEPHEW

Desiccated thyroid extract manufacturing method

PCT designated stageWO2026049785A1Powder deliveryPeptide/protein ingredientsThyroid extractMicroorganism
The present disclosure provides, among other things, methods of drying porcine thyroid gland material and manufacturing DTE comprising vacuum drying porcine thyroid gland material in a way such that the temperature of the porcine thyroid gland material is maintained above a threshold temperature. Since applying vacuum, or reducing pressure, has a cooling effect on the porcine thyroid gland material, maintaining the porcine thyroid gland material above a threshold temperature can be achieved by gradually reducing pressure while simultaneously increasing the heat applied to the porcine thyroid gland material during the period of gradual pressure change. Such methods are advantageous in reducing bioburden (killing and impeding the growth of microorganisms) while maintaining therapeutic levels of thyroid hormones, as compared to certain methods of drying porcine thyroid gland material and / or manufacturing DTE known in the art.
Owner:ALI PHARMACEUTICAL MANUFACTURING LLC

Device for controlling moisture content within a wound and monitoring the wound healing process

A bandage modulates the moisture level of a healing wound and includes sensors for detecting, collecting, and reporting data for various wound variables. The bandage may include an antimicrobial agent to reduce the bioburden of microorganisms within the bandage.
Owner:BIOADAPTIVE ADVANCED MATERIALS LLC

Method for comprehensively improving soda saline-alkali soil through cooperation of modified ardealite and microorganism-loaded biochar

The invention belongs to the technical field of saline-alkali land treatment, and particularly relates to a comprehensive improvement method for soda saline-alkali land through cooperation of modified ardealite and microorganism loaded biochar. The method comprises the following steps: cleaning ardealite by using an acidic waste liquid containing organic acid to obtain modified ardealite; mixing the modified ardealite, the saline-alkaline tolerant microorganism loaded biochar and granular aggregate to prepare a composite filler; vertical holes drilled in soda saline-alkali soil in advance are filled with the composite filler, and a reaction type permeation column is constructed; water is supplied to the reaction type permeation column, calcium ions and microbial metabolites dissolved in the column are driven to laterally permeate towards peripheral soil, and sodium ions on soil colloid are replaced. According to the invention, through system integration of'material modification 'and'spatial reconstruction', an'in-situ vertical-horizontal coupled biochemical reactor 'is constructed, and the soda saline-alkali soil is effectively improved.
Owner:NORTHEAST INST OF GEOGRAPHY & AGRIECOLOGY C A S

Sealed nutrient cartridge for imaging

PCT designated stageWO2026151459A2Sterility testingCell culture media
One among various embodiments discloses a sealed nutrient cartridge for bioburden or sterility testing, comprising a transparent cover, a flexible side panel assembly coupled to the transparent cover, a transparent film assembly coupled to the flexible side panel providing a transparent film on an opposing side of the transparent cover, wherein the transparent cover, the flexible side panel assembly, and the transparent film assembly form an interior vessel for receiving a growth medium and a sample of a product.
Owner:MANGO INC

Bioburden analyzer with ultraviolet enhancement

Bioburden analysis devices and related systems and methods are disclosed which utilize ultraviolet (UV) irradiation to enhance accuracy of results. A light source producing UV light is positioned along a passageway for a fluid flow upstream of a laser subsystem. The laser subsystem includes a laser which excites particulate within the fluid and a photo detector which measures fluorescence of the particulate within the fluid. By exposing the particulate to UV light prior to laser excitement, signal to noise ratio is increased, providing more accurate results.
Owner:METTLER TOLEDO THORNTON INC

In-situ synthesized maquinol-based binary or ternary composite reaction column as well as preparation method and application of in-situ synthesized maquinol-based binary or ternary composite reaction column

The invention belongs to the technical field of polluted water body remediation, and particularly relates to a binary or ternary composite reaction column based on in-situ synthesized maquinol as well as a preparation method and application of the binary or ternary composite reaction column. The two reaction columns are formed through a solution pretreatment-carrier filling-FeS in-situ synthesis-microbial loading technology, and the core difference lies in whether biochar is added into a carrier layer or not; a carrier layer of the'biochar-FeS-microorganism 'composite reaction column is a quartz sand-biochar mixed carrier, and an'adsorption-reduction-biodegradation' ternary synergistic system is formed; a carrier layer of the FeS-microorganism reaction column is made of pure quartz sand. The two reaction columns can continuously repair or relieve SMX-Cr (VI) composite polluted water, are used for solving the problems of low efficiency, easy material inactivation, microorganism loss, toxicity and the like of a single repair technology, are adaptive to various in-situ repair scenes such as underground water and surface runoff, and have the advantages of simple process, stable operation and easy large-scale application.
Owner:SHANGHAI UNIV