51 results about "Diabetic ulcer" patented technology

The invention relates to the technical field of biological medicine, in particular to a wound repair material and a preparation method and application thereof.The wound repair material is in a gel shape and comprises hydrogel and platelet-rich plasma, the hydrogel is formed by dynamic crosslinking of collagen and oxidized hyaluronic acid, and the hydrogel physically encapsulates the platelet-rich plasma. The gelatinous wound repair material provides bionic mechanical support through a dynamic cross-linked network, synergistically regulates and controls an inflammation microenvironment and sequential release of PRP growth factors, remarkably promotes angiogenesis and wound healing, is suitable for the clinical treatment fields of diabetic ulcer, chronic difficult-to-heal wounds and the like, and has broad application prospects. The material has the functions of mechanical support, anti-inflammatory regulation and growth factor controlled release.

This invention describes a wound dressing product for active continuous debridement of devitalized tissues in non-healing wounds including diabetic ulcers, pressure ulcers, burn injuries and other etiologies. The present invention pertains to the principle of continuous wound debridement which makes necrotic tissue more susceptible for removal and hence enhances progressive wound healing. The dressing contains an active ingredient, such as collagenase which serves to debride wounds in-situ. In the present invention purified Collagenase (90% pure) was deposited onto several wound dressing materials. A key feature of this invention is that the activity level of the Collagenase used was substantially preserved.

The present invention discloses the application of ginseng exosomes in the preparation of nanomedicines for treating diabetic ulcer vascular lesions, and relates to the field of biomedicine. The present invention verifies through experiments that ginseng exosomes can reprogram the glycolysis process of vascular endothelial cells under high sugar conditions, and inhibit the expression of acetyl coenzyme A in cells, reduce the production of reactive oxygen species, and then promote the expression of nitric oxide synthase, thereby reducing or reversing cell apoptosis induced by high sugar. Ginseng exosomes are used as nanomedicines to prevent, treat or improve diabetic ulcer microangiopathy. The ginseng exosomes in the present invention have a simple preparation process, low cytotoxicity, high delivery efficiency, and good stability. They can be used as a new type of nanomedicine for the prevention, treatment or improvement of diseases related to diabetic vascular lesions.

The application provides a thermoelectric hydrogel composite dressing for promoting repair of diabetic ulcers and loading of targeted modified exosomes and a preparation method, which comprises the following steps: preparing methacrylated hyaluronic acid; preparing polyether F127 diacrylate; co-incubating exosomes with palmitic acid grafted targeting peptides to prepare targeted modified exosomes; mixing the methacrylated hyaluronic acid, the polyether F127 diacrylate, a photosensitizer, the targeted modified exosomes and an electrolyte, and crosslinking under ultraviolet light to form a composite gel. The composite dressing is a novel composite dressing for thermoelectric stimulation and exosome treatment. On one hand, the dressing generates a wireless and passive electric field to simulate the endogenous electric field in the wound, promote directional migration of skin cells, accelerate reepithelialization and dermal formation; on the other hand, the dressing releases exosomes to precisely target blood vessels of a wound lesion, reverse endothelial dysfunction in a high-sugar environment and promote angiogenesis, and effectively solves the problems in repair and regeneration of diabetic ulcer wounds.

The invention discloses a novel drug-loaded soluble microneedle for promoting healing of diabetic ulcer and a preparation method of the novel drug-loaded soluble microneedle. The microneedle comprises effective component extracts in lipidosome, hyaluronic acid, frankincense and myrrh. The carried medicine is a classical medicine pair with tissue regeneration promoting and sore astringing, namely frankincense-myrrh, and the key active ingredients for treating the diabetic ulcer are screened out by adopting artificial intelligence-based molecular docking and network target technologies, and biological verification is carried out on the action mechanism of the key active ingredients; by adopting the carrier system and the existing components lipidosome and hyaluronic acid in the organism, the material has extremely high biocompatibility and no toxic or side effect, and shows good stability in the subsequent test, so that the time and difficulty of clinical medicine replacement are greatly reduced; the preparation process of the drug-loaded microneedle is simple, conventional equipment is used, raw materials are easy to obtain, the drug-loaded microneedle is safe, pollution-free and low in cost, economic and mental burdens of patients are relieved, and the drug-loaded microneedle has good popularization and application prospects.

The invention discloses multifunctional hydrogel as well as a preparation method and application thereof, and belongs to the technical field of medicines. The preparation method of the multifunctional hydrogel comprises the following steps: preparing an HAMA solution, a PVA solution and a MnO2 solution, constructing C18 / SDS / NaCl micelles, concentrating, mixing the components, adding a photoinitiator, carrying out ultraviolet curing, and carrying out circulating freeze thawing and cationic crosslinking to obtain a final product. The hydrogel disclosed by the invention has physiological-adaptive mechanical properties, strong adhesion in air / water, 99.8% of staphylococcus aureus resistance rate and 23.6% of ROS clearance rate in 12 hours, nearly 100% healing of mouse diabetic ulcer can be realized in 16 days, and the hydrogel is suitable for repairing chronic difficult-to-heal wounds and has remarkable clinical application value.

The present disclosure is concerned with compositions comprising insulin and a pharmaceutically acceptable topical carrier. The present disclosure is also concerned with methods of using these compositions for the treatment of a skin ailment such as a diabetic ulcer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

The invention relates to the technical field of medicines, in particular to application of rasagiline mesylate in preparation of a medicine for treating diabetic ulcer. The invention proposes that rasagiline mesylate has the effect of treating diabetic ulcer for the first time, and by adopting a mouse diabetic ulcer model, the influence of rasagiline mesylate on the healing and ROS expression of a diabetic ulcer model mouse is researched. The result shows that the rasagiline mesylate has a safe and remarkable treatment effect on the diabetic ulcer, and an important basis is provided for clinically developing an efficient strategy for treating the diabetic ulcer and preparing the medicine for treating the diabetic ulcer in the future.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a composition for topical application containing sucralfate wet gel. The invention relates to a local application composition containing sucralfate wet gel, which is prepared from the following components in percentage by mass: 15 to 25 percent of sucralfate wet gel, 10 to 18 percent of polyethylene glycol, 0.2 to 0.5 percent of polyethylene glycol stearate, 0.1 to 0.21 percent of sodium methyl p-hydroxybenzoate, 0.01 to 0.023 percent of sodium propyl p-hydroxybenzoate and the balance of purified water. The sucralfate wet gel dressing is smeared on a non-infected and carefully disinfected skin wound surface and dried, a solid barrier is formed on the part, the wound surface can be covered, damaged tissues below the wound surface can be protected against external stimulation, and the sucralfate wet gel dressing is used for treating non-infectious wound surfaces and ulcers, especially vascular ulcers, diabetic ulcers, bedsores and radiodermatitis, and has a good application prospect. A layer of protective barrier is formed on the broken or damaged surface, so that physiological healing is promoted.

The invention belongs to the technical field of biomedical materials. The invention provides a composite nano preparation for treating diabetic ulcer and promoting wound healing and a preparation method thereof. The preparation method comprises the following steps: mixing tetra (4-carboxyl phenyl) porphyrin and FeCl3. 6H2O for reaction, then adding a mixed solution composed of benzoic acid and 3, 5-dicarboxyphenylboronic acid for reaction, and then performing centrifugal drying; dispersing in water, adding a chloroplatinic acid solution, stirring, adding a sodium borohydride solution, continuously stirring, and centrifugally drying; stirring with a mixture of curcumin, flavonoid glycoside and astragaloside in ethanol, and carrying out centrifugal drying; and finally, stirring with glucose oxidase in water, and centrifugally drying. The composite nano preparation provided by the invention has an excellent antibacterial effect on multi-drug-resistant bacteria, can effectively destroy a biological membrane, can well treat diabetic ulcer and promote wound healing, and has a relatively good application prospect.

The present invention discloses a marine shellfish active peptide that can effectively promote the repair of skin wounds. The marine shellfish active peptide has good skin compatibility, can significantly promote cell proliferation, migration and angiogenesis, effectively reduce inflammatory response, promote high-quality wound repair, and reduce scar formation. The preparation method of the marine shellfish active peptide is to take the soft part of fresh marine shellfish, perform protease hydrolysis, ultrafiltration, and dextran gel separation, discard the last elution single peak, collect or mix the other elution components respectively, and freeze-dry them. The method is simple, low-cost, green and environmentally friendly, has a short production cycle, and is suitable for industrial production. The marine shellfish active peptide of the present invention can be applied to medicines, medical biomaterials and cosmetics, has a wide range of uses, and has significant effects on promoting the regeneration and repair of burns, scalds, cuts, traffic injuries, surgical injuries, combat injuries, firearm injuries combined with seawater immersion injuries, diabetic ulcers, inflammatory ulcers, pressure ulcers and chronic difficult-to-heal wounds.

The invention provides a traditional Chinese medicine composition as well as a preparation method and application thereof, and particularly belongs to the technical field of medicine preparation. The invention provides a traditional Chinese medicine composition. The traditional Chinese medicine composition comprises mulberry leaf water and a second component, the second component comprises mulberry leaf powder and / or cortex phellodendri powder; all the components are independently subpackaged; the preparation method of the mulberry leaf powder comprises the following steps: performing charcoal burning and crushing on mulberry leaves to obtain mulberry leaf powder; the preparation method of the cortex phellodendri powder comprises the following steps: calcining and crushing cortex phellodendri to obtain cortex phellodendri powder; the preparation method of the mulberry leaf water comprises the following steps: mixing mulberry leaves and water, decocting, and filtering to obtain the mulberry leaf water. The traditional Chinese medicine composition disclosed by the invention can play a local hypoglycemic role, promote rapid healing of an ulcer surface, realize treatment of diabetic ulcer, and relieve pain and economic burden of a patient suffering from diabetic skin ulcer.

The invention relates to application of adenine in preparation of a medicine for treating diabetic ulcer. The present disclosure provides an application of a pharmaceutical composition comprising adenine and / or a pharmaceutically acceptable salt thereof in the preparation of a medicament for treating diabetic ulcer, which can effectively accelerate and enhance wound healing of diabetic ulcer and can also prevent scar formation.

The invention relates to application of liquiritigenin or pharmaceutically acceptable salt thereof in preparation of a medicine for treating diabetic ulcer. The compound can be used for treating diabetic ulcer.

The application discloses a kind of fusion polypeptide SynExo for targeted delivery and its engineering exosome preparation method.The fusion polypeptide includes PDGFR beta transmembrane domain (FIASFFLAVVTLLVLLYF), photocontrol cross-linking site 4-azidophenylalanine (AzF) and double-targeting peptide CRGDKGPDC, is connected in series by flexible linker GGGGS, realizes the efficient anchoring, accurate targeting and space-time controllable delivery of exosome.The high hydrophobicity (GRAVY value +2.3) of PDGFR beta transmembrane domain makes its anchoring efficiency increase by 2.7 times, AzF generates azinome intermediate under 365nm light to realize irreversible cross-linking, double-targeting peptide targets integrin αvβ3 and ECM1 by cRGD (Kd=25nM) and KGPDC (Kd=1.2nM) synergistically, and penetration depth reaches 180 μm.Engineering exosome realizes AzF accurate incorporation by lentivirus packaging combined with orthogonal tRNA system, and in diabetic ulcer model, targeted enrichment efficiency reaches 6.8 times of unmodified group, and wound closure rate is 92.5%, which is significantly better than that of control group.The application provides an innovative platform for targeted treatment of diseases such as tumors and diabetic ulcers.

The present invention provides the application of lithospermic acid in the preparation of drugs for treating diabetic ulcers, belonging to the technical field of drugs for diabetic ulcers. The present invention first proposes that the traditional Chinese medicine monomer lithospermic acid has the effect of treating diabetic ulcers. By using a mouse diabetic ulcer model and the human keratinocyte cell line HaCaT, the effects of lithospermic acid on the healing indexes and the expression of inflammatory indexes of diabetic ulcers in mice and in vitro cells are studied. The results show that lithospermic acid has a significant therapeutic effect on diabetic ulcers, providing an important basis for the future clinical development of efficient strategies for treating diabetic ulcers and the preparation of drugs for treating diabetic ulcers.

The invention belongs to the technical field of biological medicines, and relates to application of centella asiatica exosomes in preparation of medicines for preventing, relieving or treating diabetic ulcers. The centella asiatica exosome can reduce inflammatory response, increase secretion of collagen, promote migration of epithelial cells, inhibit scar formation, inhibit growth of fibroblasts, promote matrix deposition, promote epithelial regeneration of wounds and effectively promote healing of diabetic ulcers.

The invention relates to the technical field of drugs for treating diabetic ulcer, in particular to application of genkwanin in preparation of drugs for treating diabetic ulcer. It is found that genkwanin has the effect of treating diabetic ulcer, a remarkable treatment effect is achieved, healing and reepithelization of diabetic ulcer wounds can be promoted, the content of active oxygen in the diabetic ulcer wounds can be reduced, and technical support is provided for clinically developing efficient strategies to treat diabetic ulcer in the future.

A high-frequency electrotherapy device for promoting the healing of chronic, non-healing wounds, comprising: a signal generation module configured to generate a high-frequency alternating electrical signal in the range of 1.0 MHz to 1.8 MHz with a waveform selected from sinusoidal or pulsed sinusoidal profiles; a power amplification circuit electrically coupled to the signal generation module and configured to boost the signal to a therapeutic voltage in the range of 200 V to 500 V RMS; a dielectrically coated glass electrode containing a noble gas selected from neon, argon, or xenon, the electrode being shaped for direct surface application to skin wounds and being removably coupled to the output of the power amplification circuit via a high-voltage coupling capacitor; a microcontroller-based feedback system configured to monitor skin impedance in real time and dynamically modulate output amplitude and treatment duration to maintain local tissue exposure within predefined bioimpedance and thermal safety thresholds; a safety locking mechanism comprising a capacitive proximity sensor embedded in the electrode rod, wherein signal output is only permitted upon proven contact with human skin within a calibrated pressure and proximity range; and a programmable user interface configured to execute wound-specific treatment protocols that include predefined exposure durations, modulation frequencies, and rest intervals optimized for diabetic ulcers, pressure ulcers, and post-operative wounds.

The invention relates to the technical field of medicines, in particular to application of vanillic acid in preparation of a medicine for treating diabetic ulcer. The invention proposes that the vanillic acid has the effect of treating the diabetic ulcer for the first time, and by adopting a mouse diabetic ulcer model and a human skin fibroblast line HSF, the influence of the vanillic acid on the healing and ROS expression of a diabetic ulcer model mouse and the effect of the vanillic acid on the healing index and inflammatory response of the diabetic ulcer on in-vitro cells are researched. The result shows that the vanillic acid has a remarkable treatment effect on the diabetic ulcer, and an important basis is provided for clinically developing an efficient strategy for treating the diabetic ulcer and preparing the medicine for treating the diabetic ulcer in the future.

The invention relates to application of oroxylin A in preparation of a medicine for treating diabetic ulcer. The compound can be used for treating diabetic ulcer.

The invention relates to the technical field of biology, in particular to a compound polysaccharide-fish skin source collagen scaffold as well as a preparation method and application thereof. According to the preparation method, tilapia skin is taken as a raw material, collagen is extracted and prepared under the condition that the temperature is lower than the denaturation temperature of the collagen, then astragalus polysaccharide and angelica polysaccharide are selected as drugs carried by the collagen scaffold, and the fish-derived collagen scaffold with biological activity is constructed and used for loading bone marrow mesenchymal stem cells (BMSCs). The oxidative stress injury of the BMSCs can be effectively reduced, the proliferation of the BMSCs can be promoted, the diabetic ulcer wound surface can be repaired, and the wound surface healing can be promoted. The stem cell scaffold with biological activity is constructed by utilizing the traditional Chinese medicines astragalus polysaccharide and angelica polysaccharide for the first time, and the advantages of the traditional Chinese medicines are exerted; meanwhile, the collagen adopted by the invention is derived from fish skin instead of mammals, so that religious barriers, mammalian infectious diseases and the like are avoided.

This invention describes a wound dressing product for active continuous debridement of devitalized tissues in non-healing wounds including diabetic ulcers, pressure ulcers, burn injuries and other etiologies. The present invention pertains to the principle of continuous wound debridement which makes necrotic tissue more susceptible for removal and hence enhances progressive wound healing. The dressing contains an active ingredient, such as collagenase which serves to debride wounds in-situ. In the present invention purified Collagenase (90% pure) was deposited onto several wound dressing materials. A key feature of this invention is that the activity level of the Collagenase used was substantially preserved.

This invention discloses an engineered probiotic for promoting wound healing, its construction method, and its application. The engineered probiotic is Escherichia coli Nissle 1917 (… Escherichia coli This invention provides an engineered probiotic for promoting wound healing. The engineered bacteria, derived from the Nissle 1917 (EcN) strain with its ThyA gene knocked out, has a nucleotide sequence shown in SEQ ID NO.1. The engineered bacteria constructed in this invention retain the beneficial immunomodulatory activity of EcN (particularly its potential ability to promote the transformation of macrophages into a pro-repair phenotype), while allowing for precise control of its colonization in vivo. This allows for the safe and controllable correction of the abnormal inflammatory microenvironment of diabetic ulcers, thereby effectively promoting wound healing.

The application discloses a novel brown algae polysaccharide SARP for promoting healing of diabetic ulcers and a preparation and application thereof. A novel SARP is obtained through Sephacryl S-300 / HR gel column separation and purification, and the molecular weight of the SARP is about 45.4 kDa, which is composed of mannuronic acid (76.56%), guluronic acid (18.89%) and a small amount of glucuronic acid (4.55%). Compared with alginate separated from other brown algae, the SARP has a higher content of mannuronic acid. The SARP shows a better in-vitro antioxidant capacity, and can obviously reverse the cell damage of HUVECs caused by H2O2 and high sugar in the HUVECs. In addition, the SARP can promote the migration and tubular formation of the HUVECs. In-vivo experiments further show that the SARP can promote the healing of diabetic ulcer in rats, and can reduce the oxidative stress, inflammation level and lipid disorder in the rats. The SARP has a simple purification route, can be prepared in a large amount, and is a very promising novel drug for treating diabetic foot ulcers.

The invention discloses a pharmaceutical composition (a gel) for diabetic ulcer. The gel comprises Fusidic acid and a biopolymer in the form of Chitosan, and a peptide in the form of hydrolyzed Collagen. Specifically, the gel comprises an antibacterial, Fusidic acid with a biopolymer, Chitosan and natural peptide of Type I Collagen. The composition is found to be therapeutically highly effective as a result of the unique and desirable physical, chemical and therapeutic properties of collagen embedded in chitosan gel framework with Fusidic acid.The composition is stable despite incorporation of Chitosan & hydrolyzed Collagen into a process of Fusidic acid of very low particle size. The composition has 0.1% (w / w) to 5% (w / w) of Sodium Fusidate and Chitosan of molecular weight in the range of 250,000 Da to 500,000 Da in the weight proportion of 1.25% (w / w), and the hydrolyzed Collagen of molecular weight in the range of 3000 Da to 6000 Da in the weight proportion of 0.2% (w / w).

The invention discloses a decellularized fat matrix membrane for refractory wounds and a preparation method of the decellularized fat matrix membrane. The preparation method comprises the following steps: acquiring adipose tissue through liposuction, performing mechanical crushing, SDS / Triton X-100 combined decellularization, peracetic acid / ethanol combined disinfection, supercritical CO degreasing, low-temperature crushing and the like to obtain an acellular matrix, and performing EDC / NHS crosslinking and freeze-drying remodeling to form a membrane structure with the porosity of 70-80% and the thickness of 0.5-1 mm. The membrane has excellent biocompatibility, mechanical strength and tissue regeneration promoting capacity, and is suitable for repairing refractory wounds such as diabetic ulcers and burns.

This invention provides a natural wound ointment dressing to address the problem of applying natural ingredients to the treatment of pressure sores, diabetic ulcers, and burn wounds; the natural wound ointment dressing is composed of the following natural ingredients: curcumin, Manuka honey, tea tree oil, and aloe vera gel.

The invention discloses a traditional Chinese medicine ointment for treating diabetic ulcer and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines and ointment preparation. According to the traditional Chinese medicine ointment, effective components in the traditional Chinese medicine raw materials are extracted and blended into an ointment form through a specific preparation process, and the traditional Chinese medicine ointment is prepared by carefully selecting the traditional Chinese medicine raw materials with the effects of promoting blood circulation to remove blood stasis, clearing away heat and toxic materials, removing slough and promoting tissue regeneration and the like according to the pathological characteristics of diabetic ulcer. The traditional Chinese medicine composition has the effects of resisting inflammation, resisting bacteria and promoting blood circulation and cell regeneration, can directly treat an ulcer surface, and effectively promotes ulcer healing.

The application belongs to the field of biomedical polymer materials and regenerative medicine, and particularly relates to an intelligent hydrogel for treating skin tissue damage, a preparation method and a medicine thereof, and application thereof. The intelligent hydrogel comprises a hydrogel support and a functional module. The hydrogel support takes methacrylated gelatin as a matrix and forms a stable three-dimensional network structure through photo-crosslinking. The functional module comprises two core DNA chains, one of which is a ZnR-Cage chain with a sulfhydryl group directly or indirectly connected to one end of the chain, and the other is a CD44-link chain. The two chains form a non-active assembly through base complementary pairing. The intelligent hydrogel has many advantages such as strong spatiotemporal controllability, overcoming drug burst defects, efficient cascade repair, realizing targeted synergistic treatment, efficient integration, excellent stability and clinical transformation potential. It is particularly suitable for clinical treatment of complex wounds such as diabetic ulcers and infected wounds.