204 results about "Diabetic ulcers" patented technology

The invention discloses a lightweight diabetic foot ulcer image segmentation method and system, and relates to the technical field of medical image processing, and the specific steps are as follows: obtaining a to-be-segmented image, and preprocessing the to-be-segmented image to obtain a preprocessed image; inputting the pre-processed image into a pre-trained sugar foot ulcer image segmentation model to obtain a segmented image; wherein the sugar foot ulcer image segmentation model adopts an MC-UNet network architecture and comprises an encoder, an LSDE module and a decoder which are connected in sequence, and the LSDE module introduces a channel and space attention mechanism and a multi-head cross-axis attention mechanism so as to capture a long-distance dependency relationship in the preprocessed image and enhance feature expression. According to the method, the visual state space module group is used for multi-scale feature extraction, and an adaptive solution is provided for the diversity of the size and form of the diabetic foot ulcer area, so that the segmentation precision and stability are remarkably improved.

The invention relates to the technical field of hydrogel spray preparations, in particular to hydrogel containing plant exosomes as well as a preparation method and application of the hydrogel. The invention provides hydrogel containing plant exosomes, the hydrogel comprises plant exosome freeze-dried powder and a hydrogel base solution, and the plant exosome freeze-dried powder comprises houttuynia cordata exosome powder, aloe exosome powder and honeysuckle exosome powder in a mass ratio of (1-2): (2-4): (1-2). The plant exosome compound has excellent effects of resisting inflammation, inhibiting bacteria and promoting epidermal cell proliferation; the plant exosome and the temperature-sensitive hydrogel are subjected to complementary synergism in the medication mode and the treatment effect, the temperature-sensitive hydrogel containing the plant exosome can effectively increase the diabetic foot ulcer wound repair speed, and the hydrogel can slowly release the exosome and treatment factors contained in the exosome to achieve the treatment effect. The selected biodegradable hydrogel is quick and long in curative effect, and the influence of waste generated after treatment on the environment is not increased.

The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and / or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).

The invention belongs to the technical field of diabetic foot ulcer early-stage active protection, and particularly relates to a diabetic foot gait training system based on tactile sense direction guidance. The system comprises an intelligent insole system, a cloud platform, a flexible tactile feedback interface and mobile terminal software. The intelligent insole system collects plantar pressure data in the gait process of a user and sends the pressure data to the cloud platform and the mobile terminal software through wireless communication; the cloud platform calculates sole accumulated pressure distribution in a specified time period, and when the accumulated partial pressure distribution is abnormal, control data is sent to the flexible tactile feedback interface through Wi-Fi; the flexible tactile feedback interface receives data of the cloud platform to generate tactile direction guidance, and gait training is achieved; and mobile terminal software can check a plantar pressure cloud picture and a pressure curve in real time. The training system generates direction prompts through tactile codes, guides a patient to actively adjust abnormal gaits, changes plantar pressure distribution and reduces the morbidity of diabetic foot ulcers.

The invention belongs to the field of medical rehabilitation, and particularly discloses a diabetic foot ulcer patient non-load exercise rehabilitation exercise decision support system which comprises an evaluation grading module used for obtaining multi-mode ulcer data of a patient and scientifically grading diabetic foot ulcers of the patient in combination with a layering algorithm to obtain a grading result; the scheme generation module is used for matching a non-load exercise scheme suitable for the patient in a database according to the grading result and generating an initial exercise scheme; the exercise feedback module is used for sending the initial exercise scheme to a patient terminal, acquiring the exercise completion condition of the patient and performing personalized adjustment on the exercise intensity and frequency through a dynamic regulation and control mechanism; according to the method, static ulcer features and dynamic physiological features are combined through a multi-modal data fusion technology, automatic grading is realized based on an AI algorithm, and scientificity and consistency of grading evaluation are remarkably improved.

The invention discloses a double-response collagen-based conductive hydrogel, a medicine and a preparation and application method of the double-response collagen-based conductive hydrogel. The preparation method of the double-response collagen-based conductive hydrogel comprises the following steps: carrying out chemical modification on polysaccharide through 3-aminophenylboronic acid, and then carrying out sodium periodate oxidation treatment to obtain a dialdehyde polysaccharide grafted aminophenylboronic acid copolymer; the preparation method comprises the following steps: performing hydrazide modification on collagen through adipic acid dihydrazide, and performing free radical polymerization with aniline to obtain a hydrazide collagen grafted polyaniline copolymer; the dialdehyde polysaccharide grafted aminophenylboronic acid copolymer and the hydrazide collagen grafted polyaniline copolymer are subjected to crosslinking, and the double-response collagen-based conductive hydrogel capable of responding to glucose and the pH value is obtained. Compared with single-response conductive hydrogel, the hydrogel can specifically respond to the microenvironment of chronic diabetic wound surfaces and release antibacterial and anti-inflammatory drugs, and high-quality healing of chronic wounds such as diabetic foot ulcers and the like is promoted.

The invention discloses application of conductive hydrogel combined with electrical stimulation in treatment of diabetic foot ulcer caused by neuropathy, and belongs to the field of biological medicine. The conductive hydrogel is obtained by mixing chitosan, polyvinyl alcohol, MXene and gelatin; the chitosan is catechol group modified chitosan, the MXene is polyphenol and Mg ion modified MXene, the gelatin is phenylboronic acid modified gelatin, the electrical stimulation condition is 100 mV cm <-1 >, and the diabetic foot ulcer comprises diabetic foot ulcer caused by neuropathy. Experiments prove that the prepared conductive hydrogel can promote cell migration in combination with electrical stimulation, wound healing of the diabetic foot ulcer can be accelerated, functional repair can be achieved, and a new thought is provided for clinical treatment of the diabetic foot ulcer caused by neuropathy.

The invention relates to the field of hydrogel materials, in particular to a hydrogel dressing as well as a preparation method and application thereof. The deferoxamine mesylate is loaded on the gelatin microsphere material constructed by the gelatin and the genipin, so that the loading dispersion of the deferoxamine mesylate can be benefited, and the added gelatin can be in contact with matrix proteinase-9 in a diabetic foot ulcer microenvironment for degradation so as to induce the release of the deferoxamine mesylate. A first cross-linked network is formed by the 3-carboxyphenylboronic acid modified chitosan and the oxidized hyaluronic acid, and the gelatin microsphere material loaded with the deferoxamine mesylate and the epigallocatechin gallate are coated with the first cross-linked network. The hydrogel dressing realizes controllable release of the deferoxamine mesylate and the epigallocatechin gallate, so that the technical problem of uncontrollable release of the deferoxamine mesylate is solved.

The invention belongs to the technical field of polypeptides and biological medicines, and particularly relates to a WK7 series antibacterial peptide and application thereof in the aspects of resisting bacteria and preventing and treating diabetic foot, pneumonia and septicemia. According to the invention, a linear peptide WK7-line with an amino acid sequence of WKRWKRW is used as a minimum active unit, and modification is carried out to form a plurality of linear modified peptides; meanwhile, a cyclic peptide WK7-cyl is formed on the basis of the linear peptide WK7-line through cyclization, and the cyclic peptide WK7-cyl is further modified to form an annular modified peptide. The linear peptide WK7-line, the linear modified peptide, the cyclic peptide WK7-cyl and the cyclic modified peptide jointly form the WK7-series antibacterial peptide, and the WK7-series antibacterial peptide is artificially synthesized polypeptide, is small in molecular weight, easy to synthesize, free of cytotoxicity, almost free of hemolysis risk, high in sterilization speed and broad-spectrum antibacterial property and can be used for preparing the antibacterial peptide. The traditional Chinese medicine composition has a certain effect on prevention and treatment of diabetic foot ulcer, pneumonia and septicemia.

The invention discloses a COF electrostatic spinning wound dressing with near-infrared response and antioxidant activity and a preparation method of the COF electrostatic spinning wound dressing, and belongs to the field of application materials and technologies. The COFs are synthesized from cobalt hexafluorophthalocyanine (CoPcF16) and ellagic acid (EA). The COFs is prepared into the spinning membrane, and the COFs spinning membrane has very strong oxidation resistance, can effectively remove excessive endogenous ROS, can respond to near infrared to generate exogenous ROS, and can effectively kill bacteria at a wound and improve blood flow and healing of the wound. The COFs spinning membrane prepared by the invention is simple and convenient in preparation method, good in biocompatibility, strong in oxidation resistance and capable of responding to near infrared to produce ROS, and has strong application potential in the field of treatment of a series of infected wounds, especially treatment of diabetic foot ulcers.

The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and / or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).

The invention relates to the technical field of medical dressings, and discloses a preparation method of a three-dimensional structure hydrogel dressing for diabetic foot ulcers, the hydrogel dressing is prepared from polyvinyl alcohol, polyacrylic acid, hyaluronic acid, chitosan, poly (N-isopropylacrylamide), manganese dioxide and other materials, and through formula optimization and a 3D printing technology, the three-dimensional structure hydrogel dressing for diabetic foot ulcers is prepared. High-precision structure control is realized, and the preparation requirements of hydrogel dressings in complex shapes are met; strong electrostatic interaction and hydrogen-bond interaction occur between the interface of the grid structure hydrogel and the interface of the low-viscosity colloid, so that a stable three-dimensional flexible network structure is formed; the dressing has excellent flexibility, biocompatibility, antibacterial property and a function of promoting wound healing, and can be naturally gelated and participate in treatment of a wound microenvironment.

The invention discloses bioactive gel for accelerating wound healing. The gel is prepared from the following raw materials in percentage by weight: 0.8%-1% of bomer 980, 5%-5.5% of glycerol, 15%-20% of white vaseline, 51.7%-55% of phosphate buffer, 1.8%-2% of nano royal jelly acid, 2%-3% of recombinant III type human collagen, 0.4%-0.5% of sodium hyaluronate, 1%-3% of sodium alginate, 20%-25% of polyethylene glycol-400, 1.5%-3% of dopamine-methacrylamide copolymer, 0.5%-0.8% of nano silver and 0.3%-0.5% of phenoxyethanol. The nano royal jelly acid and the nano silver have a synergistic antibacterial effect, so that the inhibition effect on drug-resistant bacteria such as MRSA and pseudomonas aeruginosa is remarkably improved, and meanwhile, the wound epithelization can be accelerated and scar formation can be reduced through the dual effects of the recombinant III type collagen and the acetylated sodium hyaluronate. The defects that a traditional dressing is narrow in antibacterial spectrum, single in repairing effect, poor in environmental adaptability and the like are overcome, and the dressing is particularly suitable for complicated wounds such as diabetic foot ulcer and second-degree burn.

The invention discloses a pharmaceutical composition for treating diabetic foot ulcer in the technical field of medicine, the pharmaceutical composition comprises loropetalum chinense extract, angelica sinensis extract, liquorice extract, angelica dahurica extract and lithospermum erythrorhizon extract, and the application dosage form of the pharmaceutical composition is gel. A hydrogel carrier of the gel is antibacterial hydrogel which is formed by PDLA-CPC-PDLA and PLLA-PEG-PLLA through complexation, and the antibacterial hydrogel is adhered to an application capable of being heated by self; the antibacterial hydrogel is fixed on the surface of a wound through the application, the medicine is separated out from the hydrogel by utilizing the temperature difference between a patient and the application, and the medicine is accumulated on the surface of the wound, so that the absorption of the medicine by the wound is facilitated, and the healing process of the wound is accelerated.

The invention discloses a traditional Chinese medicine composition for treating diabetic foot ulcer and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine, the traditional Chinese medicine composition comprises the following components in parts by weight: 2-10 parts of radix saposhnikoviae, 2-10 parts of notopterygium root, 20-40 parts of ramulus mori, 10-20 parts of gallnut, 2-10 parts of cortex phellodendri, 2-10 parts of radix angelicae, 10-30 parts of rheum officinale, 2-10 parts of fructus forsythiae and 5-15 parts of honeysuckle. The traditional Chinese medicine composition has a good treatment effect on diabetic foot ulcer, and effectively solves the problem of poor curative effect in the prior art.

The invention relates to the technical field of biomarkers, in particular to a biomarker composition for diabetic foot ulcer and application of the biomarker composition. The invention provides a biomarker combination for diabetic foot ulcer. The biomarker combination comprises a DDIT4 gene and a PKM gene. According to the invention, by integrating transcriptome sequencing data and single cell sequencing data, biomarkers DDIT4 and PKM closely related to diabetic foot ulcer (DFU) are successfully screened out. The expression of the two genes in a disease group is remarkably up-regulated, and the two genes are stably expressed in different data sets, so that a reliable molecular target is provided for early diagnosis of DFU.

The invention discloses a traditional Chinese medicine composition for diabetic foot ulcer and a preparation method thereof. Comprising effective extracts of folium ginkgo, radix astragali, rhizoma corydalis and rhizoma anemones raddeanae as active pharmaceutical ingredients. The traditional Chinese medicine composition has an obvious improvement effect on diabetic foot ulcer, the cure rate of a rat with the diabetic foot ulcer can be obviously increased, wound healing is accelerated, and the action mechanism of the traditional Chinese medicine composition is closely related to a Wnt / beta-catenin signal channel. In addition, the traditional Chinese medicine composition provided by the invention also has the advantages of simplicity in preparation, low cost, convenience in carrying and remarkable effect.

The present application relates to the technical field of biological medicine, and particularly relates to a stem cell culture method for promoting wound healing and application thereof. The stem cell culture method for promoting wound healing comprises the following steps: step one, providing umbilical cord-derived mesenchymal stem cells; step two, adding luteolin and baicalin as culture medium additives in a serum-supplemented culture medium, wherein the concentration of luteolin is 1-10 micromoles / L, and the concentration of baicalin is 1-10 micromoles / L; step three, inoculating the mesenchymal stem cells into the culture medium containing the additives for culture, and the culture condition is 34-40 DEG C, 4-6% CO2, and the culture time is 48-96 hours; step four, harvesting the cultured mesenchymal stem cells to obtain stem cells for promoting wound healing. The culture method can promote the stem cells to secrete various growth factors, significantly improve the secretion of PGE2 and VEGF-C growth factors, and make the wound healing rate of the stem cell treatment group reach 96%, which has a significant effect on treating diabetic foot ulcers.

The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and / or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).

The invention discloses composite hydrogel, a preparation method and application of the composite hydrogel in preparation of a medicine for treating diabetic foot ulcer infection. The composite hydrogel comprises a methacrylated gelatin hydrogel and a cyclocarya paliurus extract product or cyclocarya paliurus leaf powder compounded in the methacrylated gelatin hydrogel. The dressing prepared by the invention realizes drug sustained release, which indicates that the hydrogel can promote long-term release of drugs, further reduce loss of liquid drugs and improve the utilization rate of the drugs, is used for inhibiting healing of diabetic foot ulcer infected wounds, and has wide clinical application prospects.

Disclosed herein is a method for treating skin wounds in a patient in need of such treatment, comprising applying a foamed composition comprising nitric oxide to the area of skin requiring such treatment. The wound may be selected from the group consisting of skin ulcers, including diabetic foot ulcers (DFUs), venous leg ulcers (VLUs), arterial ulcers, decubitus (pressure) ulcers or other pressure injuries, deep tissue injuries (DTIs), burns, abrasions, skin tears, or bruises.

The invention provides a pharmaceutical composition for treating diabetic foot ulcer as well as a preparation method and application thereof, and the pharmaceutical composition for treating diabetic foot ulcer is prepared by taking angelica sinensis, honeysuckle and scutellaria baicalensis as raw materials through pretreatment, extraction and post-treatment. The pharmaceutical composition for treating diabetic foot ulcer disclosed by the invention has a good curative effect on diabetic foot ulcer diseases; especially, an oral prescription and an external prescription are matched for use, so that the curative effect is better.

The present invention discloses the application of a conductive hydrogel combined with electrical stimulation in the treatment of diabetic foot ulcers caused by neuropathy, belonging to the field of biomedicine. The conductive hydrogel is obtained by mixing chitosan, polyvinyl alcohol, MXene and gelatin. The chitosan is chitosan modified with catechol groups, the MXene is MXene modified with polyphenols and Mg ions, and the gelatin is gelatin modified with phenylboronic acid. The condition of the electrical stimulation is 100 mV cm-1. The diabetic foot ulcers include diabetic foot ulcers caused by neuropathy. Through experimental verification, the conductive hydrogel prepared by the present invention combined with electrical stimulation can promote cell migration, accelerate the wound healing of diabetic foot ulcers and achieve functional repair. The present invention provides a new idea for the clinical treatment of diabetic foot ulcers caused by neuropathy.

A preparation method of a hydrogel for promoting growth of mesenchymal stem cells (MSCs), and a preparation method and an application method are provided. The hydrogel is rich in MSC-derived exosomes, which can effectively promote wound healing both for diabetic foot ulcer (DFU) caused by bacterial infection and for DFU caused by skin scratch. Moreover, healing speed for the DFU is fast and healing area for the DFU is wide.

The invention discloses a diabetic foot ulcer monitoring and treatment evaluation device and method based on structured light imaging. The device comprises an image acquisition module, a mechanical arm module, a man-machine interaction module and an information processing module. The mechanical arm module comprises a multi-degree-of-freedom mechanical arm, the image acquisition module comprises at least one structured light image acquisition device, and the mechanical arm drives the image acquisition module to move, acquires three-dimensional point cloud images of feet from different angles and synchronously acquires space coordinates and deflection angles of the image acquisition module; and the information processing module is used for constructing a foot three-dimensional point cloud model by utilizing the three-dimensional point cloud image and the corresponding space coordinates and deflection angles, importing the foot three-dimensional point cloud model into the trained diabetic foot detection and treatment evaluation model for analysis, and displaying a prediction result through the man-machine interaction module. According to the method, the foot three-dimensional point cloud model is reconstructed, the reconstructed model is identified, the area, the volume and the position of the wound surface are evaluated, and then the treatment effect of the current mode can be evaluated.

The utility model discloses a diabetic foot ulcer treatment dressing change device, which comprises a shoe frame, a bottom plate and a detachable component, the inner surface of the shoe frame is fixedly connected with a breathable sheet, the lower surface of the breathable sheet is provided with a medicine pad, the inner part of the shoe frame is provided with a plug pin, and the plug pin is connected with the bottom plate. The detachable assembly comprises a first limiting block, a sliding block, a sliding column, a sleeve, a spring, a clamping block and a second limiting block, the inner wall of the first limiting block is slidably connected with the sliding block, the interior of the sliding block is fixedly connected with the sliding column, the side surface of the sliding column is slidably connected with the sleeve, and the sleeve penetrates through the interior of the spring; by means of the detachable assembly, the foot pad at the bottom of the foot mold can be replaced, a traditional adhesion type foot patch dressing change mode is replaced, mounting and dismounting operation is easy and convenient, pain of a patient in the dressing change process can be reduced, the comfort level of the patient is greatly improved, and high practicability is achieved.

The present invention belongs to the field of preparation of diabetes complication remission agents, and particularly relates to a combined preparation for improving microcirculation of diabetic foot and a preparation method thereof. Starting from platelet-rich plasma, the present invention obtains exosomes containing rich active substances such as growth factors through stimulation with calcium gluconate and the like, and loads protamine nanoparticles to obtain bioactive substances with strong antibacterial ability, which can resist the development process of diabetic foot ulcers. The present invention uses bioactive glass, hydroxyethyl cellulose and the like to stabilize the bioactive substances, prolong the in vitro lifespan of the bioactive substances, and modified carboxymethyl cellulose provides better biodegradation effect. The combined preparation prepared by the present invention has less cytotoxicity, better antibacterial effect, can promote wound healing quickly, and the microcirculation index shows that it can stimulate the change of foot blood flow and improve the condition of foot artery blockage, etc.

The invention belongs to the technical field of biomedical materials, and discloses a viola philippica exosome-loaded composite hydrogel as well as a preparation method and application thereof, the composite hydrogel is prepared by mixing methacrylated polylysine (PLMA), oxidized dextran (ODex), viola philippica exosome (V-E), a photoinitiator and a physiologically compatible solvent and performing illumination crosslinking; the preparation method comprises the following steps: respectively preparing PLMA and ODex solutions, extracting and purifying V-E, adding a photo-crosslinking agent (LAP), mixing the components to obtain a precursor liquid, and carrying out in-situ curing molding through ultraviolet-visible light irradiation. The composite hydrogel provided by the invention solves the problems that the existing wound dressing is difficult to fit with irregular wounds, is antibacterial and easy to resist drugs, and lacks active anti-inflammatory and efficient healing promotion capabilities, and is suitable for repair treatment of infectious open wounds such as burns, trauma, diabetic foot ulcer and postoperative infected incisions.

The invention discloses a targeted anti-aging microneedle drug delivery system for chronic wound repair as well as a preparation method and application of the targeted anti-aging microneedle drug delivery system. The system is composed of functionalized nanoparticles and a microneedle platform: a nano drug-loading unit which takes a polydopamine nanosphere as a carrier, entraps an anti-aging drug Bem, and modifies the surface of the nano drug-loading unit with a targeting peptide E7; according to the micro-needle delivery unit, hyaluronic acid-nitrogen carboxymethyl chitosan hydrogel is used as a matrix, a nano drug-loading unit and silver ions (Ag) are loaded, a micro-needle array is formed, and minimally invasive transdermal drug delivery is achieved. According to the invention, multiple mechanisms of anti-aging (APCs aging inhibition), antioxidation (ROS removal), antibiosis (Agaction) and immunoregulation (macrophage M2 type polarization promotion) are synergistically exerted, and the bottleneck problems of single intervention target, low drug availability and difficulty in regulating and controlling pathological microenvironment of chronic wounds (such as diabetic foot ulcer) in the traditional therapy are effectively solved.

The invention belongs to the technical field of diabetic foot clinical path management, and discloses a diabetic foot patient path management method and system based on lower limb vasculopathy grading. Mapping the ulcer position to the corresponding perfusion area and the artery segment to generate ulcer space characteristics; calculating a blood supply risk score of the perfusion area and generating a space risk map by combining the blood vessel image detection data and the microcirculation detection data; then collecting time sequence data including an ulcer index, an infection index, a blood supply index and a space risk map, and predicting the progress speed and the risk level of the future ulcer course; and finally, according to the blood supply risk score and the disease course prediction result, generating an individualized path management scheme through a joint triggering rule. According to the invention, precise and dynamic management of the diabetic foot ulcer is realized, the healing rate is improved, and the recurrence rate and the medical cost are reduced.