48 results about "Diabetic foot ulceration" patented technology

An orthopedic walking boot promotes rapid healing of diabetic foot ulcerations by lowering the maximum peak pressure imposed upon the foot. The walker has a hard unyielding shell which is designed for walking. The shell closely and rigidly supports a mid-sole in a foot-shaped bed. The mid-sole has a foot-shaped cavity with rounded sides adapted to form resilient support for the heel, arch and sides of a foot in addition to the bottom of a foot. A conformable inner-sole is adapted to fit over the foot-shaped cavity in the mid-sole and be compressed in response to foot pressure between the sides and bottom of the foot and the sides and bottom of the foot-shaped cavity in the mid-sole thereby compensating for small differences between the shape of the foot and the shape of the cavity. Weight applied to the foot is transferred to the walking shell by contact between the sides of the foot, arch, and heel and the arch, heel and sides of the foot-shaped cavity as well as the bottom of the cavity thereby decreasing the peak or maximum unit pressure on the plantar surface of the foot. A breathable bootie which wraps the foot and lower leg in a protective “cocoon” is preferably secured to the upper surface of the insole thereby preventing foreign materials from entering the foot cavity.

The present disclosure provides apparatuses and methods for measuring capacitance as an indication of susceptibility to the formation of a diabetic foot ulcer.

The present disclosure provides apparatuses and methods for measuring capacitance as an indication of susceptibility to the formation of a diabetic foot ulcer.

The present invention is related to a pharmaceutical composition comprising snail slime of Helix aspersa müller (Cryptophalus aspersus) (5% to 50%) and marigold extract, propolis and / or almond oil and pharmacologically accepted additives for the prevention additives and / or pharmaceutically acceptable excipients to form a formulation of intermediate to high viscosity (200 to 1000 Pa-s). This invention also relates to the use of a composition which can be formed as a cream or a gel, is preferably soaked in gauze, and shaped as a bandage or sock for the treatment and cure of diabetic foot ulcers and other severe wounds, particularly those associated with diabetes, gout, Lesch Nyhan syndrome or other conditions to the skin, including, keratosis, onychomycosis, ringworm, among others.

This invention relates generally to an index map comprising both pressure and perfusion information from a diabetic patient foot for the purpose of treatment. The index map may also be a map of perfusion and / or metabolism of the tissue (reflecting oxygen delivery and oxygen extraction), obtained by thermal imaging, hyperspectral imaging, or duplex ultrasound, MRA, CT or laser Doppler imaging. This information aids treatment in prevention of diabetic foot ulceration and amputation and in treatment of tissue compromise to prevent tissue loss in other body regions.

The invention discloses an injectable medical wound dressing with an antibacterial function, which belongs to the field of medical biological materials. The dressing provided by the invention comprises aminated hyaluronic acid, nitrosated acetylcysteine-grafted chitosan and benzaldehyde terminated polyethylene glycol, a wound surface can be covered by injection, especially an irregular wound surface of a deep part, the dressing has good self-healing performance, can prolong the service life of the wound dressing, and reduces secondary damage caused by replacement of the wound dressing. The dressing has good biocompatibility, can continuously release nitric oxide in a physiological environment so as to play a role in bacteriostasis and promote angiogenesis, and has the potential of promoting repair of refractory wounds such as diabetic foot ulcer.

The invention discloses application of vaccarin in treating open skin lesions, and belongs to the technical field of application of a traditional Chinese medicine. The invention discovers firstly the activity of the vaccarin in promoting healing of open skin lesions, and the vaccarin is applicable to a series of diseases including diabetic foot, ulcer, tetanus, infection, rash, pathological scars, body's malnutrition, tissue necrosis, metabolism imbalance and the like related to the open skin lesions. The vaccarin is applicable to pharmaceutical preparations, cosmetics and the like.

The invention relates to a composition of glycosaminoglycans for the treatment of diabetic foot ulcer, it specifically relates to low molecular weight heparins (LMWHs) and very low molecular weight heparins (VLMWHs) in the treatment of chronic ulcers, particularly of diabetic foot ulcers, and more specifically in the manufacture of a medicinal product for the treatment of chronic ulcers, and particularly diabetic foot ulcers and pressure ulcers.

The invention discloses a method for preparing an extracellular matrix-imitated hydrogel dressing for diabetic foot ulcer. The method comprises the following steps: dispersing polydopamine nanoparticles loaded with deferoxamine mesylate in a modified human-like collagen solution, then performing mixing with an epigallocatechin gallate dimer grafted hyaluronic acid solution, and adding a tyrosinase solution to obtain the extracellular matrix-imitated hydrogel dressing. By dissolving the polydopamine nanoparticles loaded with deferoxamine mesylate in the modified human-like collagen solution, performing mixing with the epigallocatechin gallate dimer grafted hyaluronic acid solution, and quickly adding the tyrosinase solution, the extracellular matrix-imitating hydrogel dressing is prepared. The problems of angiogenesis damage and long-term chronic inflammation of diabetic foot ulcer wounds are solved in a targeted manner, angiogenesis and inflammation resistance can be effectively promoted, and the wound healing rate is high.

The invention provides antibacterial hydrogel suitable for diabetic foot ulcer and a preparation method of the antibacterial hydrogel, and belongs to the technical field of preparation of medical hydrogel. The preparation method comprises the following steps: (1) adding acrylic acid, a cross-linking agent and an initiator solution into a sodium alginate solution, and carrying out sodium alginate modification; (2) adding a medicinal active component D and an antibacterial component E, and adding a CaCl2 solution to prepare a crude gel product; and (3) washing the coarse gel, and sucking the washed coarse gel with filter paper to obtain the antibacterial hydrogel. According to the prepared hydrogel, by improving sodium alginate, the wound exudate absorption speed can be greatly increased, the wound is treated in time, traditional Chinese medicine ingredients are added, the hydrogel permeates into the wound through slow release to be absorbed by a human body, the local medication effect is achieved, and the blood supply condition of the ulcer position can be improved through addition of the conyzasaponin R, so that the healing speed of the diabetic foot ulcer is increased through a synergistic effect.

The invention discloses a fly larva protein preparation which comprises fly larva protein and a pharmaceutically acceptable carrier or excipient, wherein the specific gravity of the fly larva protein is not less than 1% of the total amount of drugs, and the purity of the fly larva protein is not less than 50%. The fly larva protein preparation has very good antibacterial and healing-promotion effects, is relatively low in cost, relatively small in side effect and less in possibility of generating drug resistance, and can be used for preparing medicaments for treating burn injury, scald injury and diabetic foot ulcer.

The invention discloses a preparation method of a bioactive medical dressing. The method comprises the following steps of S1, taking raw material solutions for later use, and performing printing through a microfluidic 3D printing assembly; and S2, introducing contents into all channels in a multi-channel coaxial jet head, controlling the flow speed, setting parameters of a 3D printer, and using the 3D printer to control a micro-fluidic chip to print the three-dimensional diabetic foot ulcer functional medical dressing, wherein the raw material solutions comprise an alginate solution, a first high-molecular polymer solution, a bioactive component solution and a second high-molecular polymer solution. According to the method, the process is simple, subsequent treatment of the dressing is not needed, the production efficiency is high, the cost is low, the product is stable, the precision is high, and the experimental repeatability is high.

A dressing comprises a delivery vehicle and platelet lysate. The dressing can also include an antimicrobial agent, a hemostatic agent, and a binder. It is contemplated that the dressing can be used for expediting hemostasis, improving antimicrobial activity, minimizing fluid loss, and accelerating wound healing when applied to a wound. The dressing would be useful in applications including military in-theater medical care and for conditions such as diabetic foot ulcers, as well as other applications.

The present invention refers to a method for preparing a herbal extract from Mellilotus sp. (Mellilotus officinalis), preferably comprising a treatment by pulsed electromagnetic field of high frequency. The herbal extract, optionally comprising selenium and / or urea and / or fructose and / or phosphoglycerol (or its sodium salt), is useful in the treatment of chronic wounds, in particular associated with states in which the normal wound repair ability is weakened, and preferably diabetic foot ulcers and / or bed sores.

The invention discloses a glucose and enzyme double-response dressing for treating diabetic chronic wounds and a preparation method thereof, and the method comprises the following steps: adding an anti-inflammatory drug into a collagen solution to form a suspension containing the anti-inflammatory drug, mixing the suspension containing the anti-inflammatory drug with a system containing an emulsifier to form an emulsion system containing the anti-inflammatory drug, freezing the anti-inflammatory drug emulsion system, and mixing the anti-inflammatory drug emulsion system with a glutaraldehyde solution for reaction to obtain enzyme response collagen drug-loaded microspheres; mixing and reacting a system containing the enzyme response collagen drug-loaded microspheres, insulin and modified chitosan with a polyvinyl alcohol solution to obtain the glucose and enzyme double-response dressing for treating the chronic wound surface of the diabetes mellitus. The dressing prepared by the method disclosed by the invention has the characteristic of double response of glucose and matrix metalloproteinase-9, can effectively absorb tissue seepage and keep a wound moist, can perform intelligent drug delivery according to the characteristic that a diabetic foot ulcer wound has high glucose and MMP-9, and solves the two prominent problems of the wound; and the wound healing is accurately and efficiently promoted.

The present invention discloses a wound dressing with high absorption capacity and the method of manufacturing. The wound dressing is a knitted fabric comprising of a fluffy layer of gelling fibres and a layer of non-gelling fibres as the backing. The gelling fibres are knitted onto the backing structure and the length fluffy fibre outside the backing structure is between 1-100 mm, preferably 5-50 mm. The wound dressing can be used to manage chronic wounds such as venous stasis ulcers, pressure ulcers, diabetic foot ulcers and other chronic ulcer wounds.

The present invention concerns new compositions containing hyaluronic acid or the derivatives thereof in association with the proteolytic enzyme collagenase (and relative pharmaceutical formulations) for the preparation of a dressing for topical treatment of various kinds of wounds, burns of varying depth, pressure sores, vascular ulcers and diabetic foot ulcers as well as for the treatment of hypertrophic and keloid scars.

The invention aims at providing a traditional Chinese medicinal composition for treating diabetic foot ulcer, positive ulcer and positive sore. The traditional Chinese medicinal composition is rigorous in prescription and effective in clinical application; and the traditional Chinese medicinal composition is capable of effectively improving states of redness, swelling, heat and pain around the diabetic foot ulcer, positive ulcer and positive sore, so that the traditional Chinese medicinal composition can improve edema, improve local micro-circulation, promote healing of ulcer surfaces, diminish wound areas and reduce an amputation rate.

The invention relates to the technical field of pharmaceutical chemistry, in particular to polypeptide hydrogel loaded with small interfering RNA and a preparation method and application of polypeptide hydrogel. The amino acid sequence of polypeptide is SEQ ID NO: 1, and the N end of the polypeptide is acetylated. After the polypeptide hydrogel is smeared on a wound, the retention rate of MMP-9siRNA compound on the wound can be effectively increased, use is convenient, and secondary mechanical damage to the wound can be avoided. The MMP-9siRNA is slowly released for a long time, and the function of the siRNA for inhibiting the MMP-9 is better played; an acidic and moist environment is provided, excessive alkaline exudate on the local part of a wound is neutralized and absorbed, the times of dressing change can be reduced, the discomfort or pain of a patient is reduced, the compliance of the patient is improved, and the healing of diabetic foot ulcer is promoted; and the polypeptide source and histocompatibility are good, no obvious toxic or side effect exists, the preparation condition is mild, the process is simple, operation is convenient, and industrial production can be achieved easily.

The invention discloses an application of an engineered exosome in skin regeneration and repair of diabetic foot ulcer and a preparation method of the engineered exosome. The engineered exosome is characterized in that the exosome is used as a gene vector to load a gene for promoting vascular regeneration, and meanwhile, the exosome derived from stem cells contains various active factors to promote anti-infection of wound surface and repair of the blood vessel network and nerve. The exosome derived from adult stem cells is used for replacing stem cells which are strictly used clinically due toimmunogenicity and tumorigenicity, and the gene cargos of the synergistically loaded active molecules have the characteristics of multiple functions and good treatment effect, so that the exosome canbe widely applied to clinical repair of skin wound defects, particularly the regeneration and the repair of diabetic foot ulcerated skin.

The invention discloses a diabetic foot protection shoes adapting method and system. The method comprises the steps that the degree of peripheral neuropathy of the diabetic foot of a subject is determined according to a diabetic foot Michigan score table; according to the degree of peripheral neuropathy of the diabetic foot, a first score is determined; a static foot image of the subject is acquired; the ratio of the footprint width of a lumbar region to the width of the footprint of a forefoot in the static foot image is acquired; a second score is determined according to the ratio; the solepressure peak of the subject is acquired; and a third score is determined according to the sole pressure peak. The method or system comprehensively considers three main factors determining the occurrence of diabetic foot ulcers, namely foot peripheral neuropathy, foot deformity and foot pressure distribution, and acquires the total score of three factors. Based on the corresponding relationship between the diabetic foot level and the key parameters of protection shoes, accurate adaptation of the diabetic foot protection shoes is realized.

The invention relates to an external application traditional Chinese medicine for treating diabetic foot ulceration wound surfaces. The external application traditional Chinese medicine is characterized by comprising, by weight, about 21% of calcined gypsum, about 13% of calcined oyster shell, about 13% of stalactite, about 9% of borax, about 2% of borneol, about 9% of radix angelicae, about 9% of bletilla striata, about 4% of dried alum, about 4% of frankincense, about 4% of myrrh, about 4% of indigo naturalis, about 4% of daemonorops draco and about 4% of the root of red-rooted salvia. The components are ground into powder to be externally applied to the wound surfaces. By means of the external application traditional Chinese medicine, healing of the wound surfaces of diabetic foot patients is promoted, the amputation is avoided, and the living quality of the patients is improved.

Disclosed are methods, devices, and systems for treatment of an abnormal wound healing response. The methods, devices, and systems can be used to treat solid ulcerated tissue, such as diabetic foot ulcers (DFUs), arthritic tissue, muscle soreness, joint pain, varicose veins, obesity, and peripheral artery disease. Additionally, the methods, devices, and systems can promote the healing of xenograft, allograft, autograft, or engineered tissue following reconstruction surgery. The methods, devices, and systems include the ability to determine an optimal set of pulse parameters that are specific to wound healing. In embodiments, the methods, devices, and systems include components for guiding the user on electrode placement based on anatomical or electrical measurements, delivering a custom series of electric pulses, applying heat, and using feedback from physiologic measurements to control the device.

The invention discloses application of piroxicam in preparation of a medicine for treating skin ulcer and a preparation method of the medicine. The medicine is prepared from piroxicam and pharmaceutically acceptable auxiliary materials. The piroxicam can promote migration of human umbilical vein endothelial cells (HUVEC cells) under high glucose stimulation, so that healing of diabetic foot ulcerwounds is promoted; and the piroxicam has a remarkable curative effect on skin ulcer, especially diabetic foot ulcer.

The invention relates to a nucleic acid construct, which comprises an insertion fragment and is characterized in that the insertion fragment comprises a polynucleotide sequence for coding an affinity tag, intein and an epidermal growth factor from the 5' end to the 3' end, the affinity tag is a GST affinity tag, and the intein is gp41-1 protein. The research reveals the ability of the gp41-1 micro intron in the aspects of intracellular expression and C-exon lysis of the EGF fusion protein. The finally purified EGF is proved to have very high activity in the aspect of accelerating the healing speed of bedsore, diabetic foot ulcer and skin rupture.

The present disclosure relates to a gel formulation for treating diabetic foot ulcer infections. The gel formulation comprises antibiotic loaded aquasomes, a gelling agent, a preservative, and a fluid medium. The gel formulation of the present disclosure can be used for treating diabetic foot ulcer infections in mammals.

The invention discloses a skin wound healing preparation, and the effective components of the skin wound healing preparation comprise an epidermal growth factor and / or a fibroblast growth factor, the epidermal growth factor and / or the fibroblast growth factor are / is obtained by culturing transformed host cells; the transformed host cell comprises an expression vector, the expression vector comprises a nucleic acid construct, and the nucleic acid construct comprises an insert, the insert comprises, from the 5'end to the 3'end, a polynucleotide sequence encoding an oligopeptide affinity tag, a trans-spliced intein derived from Anabaena sp., and an exogenous polypeptide, wherein the oligopeptide affinity tag is used as the N-terminal exon peptide of the trans-spliced intein, and the exogenous polypeptide is used as the C-terminal exon peptide of the trans-spliced intein. Through local application of the skin wound healing preparation, the cure rate of diabetic foot ulcers, bedsores and hard-to-heal wounds is greatly increased.

The invention discloses a preparation method of a three-dimensional diabetic foot ulcer functional medical dressing. The preparation method comprises the following steps: S1, taking a core layer solution, a middle layer solution and a shell layer solution; conducting printing through the microfluidic 3D printing assembly, so as to introduce the core layer solution into the inner phase channel, introduce the middle layer solution into the middle phase channel, and introduce the shell layer solution into the outer phase channel; and S2, controlling the flow velocity in each channel, setting parameters of a 3D printer, making the flow velocity of the inner phase channel 0-110 mL / h, the flow velocity of the intermediate phase channel 150-270 mL / h, and the flow velocity of the outer phase channel 30-110 mL / h, and utilizing the 3D printer for controlling the micro-fluidic chip to print the three-dimensional diabetic foot ulcer functional medical dressing. According to the scheme of the invention, by controlling the speed, the three-dimensional structure assembled by the microfibers with multiple layers of shell / core structures can be obtained, the size can be regulated and controlled, the swelling rate, the water absorption rate and the like are good, and the medical dressing has good application prospects in diabetic foot ulcer medical supplies.

The invention discloses an injectable medical wound dressing with antibacterial function, which belongs to the field of medical biological materials. The dressing of the present invention comprises aminated hyaluronic acid, chitosan grafted with nitrosated acetylcysteine, and benzaldehyde-capped polyethylene glycol, which can cover wounds by injection, especially irregularities in deeper parts. wound, and has good self-healing properties, which can prolong its use time and reduce secondary injuries caused by changing wound dressings. The dressing has good biocompatibility and can continuously release nitric oxide in a physiological environment, thereby playing an antibacterial role, while promoting angiogenesis, and has the potential to promote the repair of difficult-to-heal wounds such as diabetic foot ulcers.