An injectable medical wound dressing with antibacterial function

A wound and functional technology, applied in the fields of medical science, pharmaceutical formulations, bandages, etc., can solve the problems of severe infection refractory, poor wound healing effect, limited antibacterial ability, etc., and achieve good self-healing performance, good Covering effect, repairing effect

Active Publication Date: 2021-12-14
无锡贝迪生物工程股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a natural polymer with antibacterial effect, chitosan has been used in wound dressings, but the hydrogel material prepared by chitosan itself has limited antibacterial ability. For severe infection and refractory wounds, chitosan water Gel does not work well in promoting wound healing

Method used

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  • An injectable medical wound dressing with antibacterial function
  • An injectable medical wound dressing with antibacterial function
  • An injectable medical wound dressing with antibacterial function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] The preparation of embodiment 1 raw material

[0052] figure 1 a is amino hyaluronic acid (HA-NH 2 ), the specific synthesis route is as follows: Weigh 200 mg of low molecular weight sodium hyaluronate HA-TLM20-40 into a 250 mL round bottom flask, add 100 mL of deionized water and stir until completely dissolved at room temperature, and use 0.5 M The pH of the solution was adjusted to 5.5 with hydrochloric acid, and then 194.8 mg of EDC and 117.0 mg of NHS were added to activate the carboxyl group at room temperature for 30 min, and then 152.7 mg of ethylenediamine was added to react overnight at room temperature. After the reaction is completed, put the above solution into a dialysis bag with a molecular weight cut-off of 3500Da for dialysis purification, and finally pre-freeze and freeze-dry at -20°C to obtain HA-NH 2 , its H NMR spectrum is shown in figure 2 , where the new peaks at 2.03ppm and 3.01-3.34ppm are the peaks of hydrogen on the grafted ethylenediamine...

Embodiment 2

[0057] 1) HA-NH 2 / Preparation of CS-SNO solution

[0058] Add polymer HA-NH per 100 μL ultrapure water 2 5mg and CS-SNO 10.1mg, stir well with a magnetic stirrer to form a homogeneous solution at room temperature.

[0059] 2) Preparation of DF-PEG 2000 solution

[0060] Add polymer DF-PEG 2000 30 mg per 100 μL of ultrapure water, use a magnetic stirrer to stir well, and form a homogeneous solution at room temperature.

[0061] 3) Preparation of composite gel

[0062] Calculated by volume, take 1 part of HA-NH2 / CS-SNO solution and 1 part of DF-PEG 2000 solution, mix evenly under the magnetic stirrer, adjust the pH to neutral with 3M NaOH, and let it stand to get compound gel.

Embodiment 3

[0064] 1) HA-NH 2 / Preparation of CS-SNO solution

[0065] Add polymer HA-NH per 100 μL ultrapure water 2 5mg and CS-SNO 10.1mg, stir well with a magnetic stirrer to form a homogeneous solution at room temperature.

[0066] 2) Preparation of DF-PEG 2000 solution

[0067] Add polymer DF-PEG 2000 40 mg per 100 μL of ultrapure water, use a magnetic stirrer to stir well, and form a homogeneous solution at room temperature.

[0068] 3) Preparation of composite gel

[0069] By volume, take HA-NH 2 1 part of CS-SNO solution and 1 part of DF-PEG 2000 solution were mixed evenly under the magnetic stirrer, and the pH was adjusted to neutral with 3M NaOH, and the composite gel could be obtained after standing still.

[0070] Figure 4 The injectable schematic diagram of the medical wound dressing sample prepared in this example shows that the dressing of the present invention can be injected so that it can better adhere to wounds of different shapes.

[0071] Figure 5 It is a ...

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PUM

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Abstract

The invention discloses an injectable medical wound dressing with antibacterial function, which belongs to the field of medical biological materials. The dressing of the present invention comprises aminated hyaluronic acid, chitosan grafted with nitrosated acetylcysteine, and benzaldehyde-capped polyethylene glycol, which can cover wounds by injection, especially irregularities in deeper parts. wound, and has good self-healing properties, which can prolong its use time and reduce secondary injuries caused by changing wound dressings. The dressing has good biocompatibility and can continuously release nitric oxide in a physiological environment, thereby playing an antibacterial role, while promoting angiogenesis, and has the potential to promote the repair of difficult-to-heal wounds such as diabetic foot ulcers.

Description

technical field [0001] The invention relates to an injectable medical wound dressing with antibacterial function, which belongs to the field of medical biological materials. Background technique [0002] As of 2010, approximately 285 million adults worldwide were living with diabetes, and the number is expected to soar to 439 million or more by 2030. As the epidemic progresses, so does the incidence of diabetic foot ulcers. Diabetic foot ulcer is one of the serious complications of diabetes caused by foot nerve dysfunction, insufficient peripheral blood perfusion, and microcirculation disturbance. Its course of disease is repeated, wounds are difficult to heal, and treatment costs are high. burden. [0003] Peripheral nerve dysfunction in diabetic foot ulcers reduces the role of the skin protective barrier, high blood sugar and blood perfusion blockage, which can easily lead to the growth and proliferation of local bacteria and increase the incidence of infection, and the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00C08B37/08
CPCA61L26/008A61L26/0052A61L26/009C08B37/003A61L2400/06A61L2300/114A61L2300/604A61L2300/404A61L2300/412C08L5/08
Inventor 陈敬华任伟业周钰婷周娟程咏梅陆金婷
Owner 无锡贝迪生物工程股份有限公司
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