37 results about "Round-bottom flask" patented technology

The invention discloses a nano-enzyme detection method for aflatoxin B1, and relates to the technical field of analysis and detection.The method comprises the following specific steps that nano-enzyme preparation and carrier selection are conducted, specifically, nano-gold is prepared through a sodium citrate reduction method to serve as the nano-enzyme, a chloroauric acid solution is added into a round-bottom flask and heated to be boiled, and a carrier is obtained; according to the method, the PNIPAM serves as an immobilization carrier of the nano-enzyme, reversible immobilization of the nano-enzyme is achieved, cyclic utilization of the nano-enzyme is promoted, the detection cost is reduced, after detection is completed, phase change of the PNIPAM can be achieved by changing environmental conditions, and therefore effective separation of nano-gold and the carrier is achieved; after the recovered nanogold is washed and subjected to re-functionalization treatment, the catalytic activity of the nanogold is maintained, and the nanogold can be used for detecting aflatoxin B1 again, so that the utilization rate of the nano-enzyme is increased, and the waste of resources is reduced.

This invention belongs to the field of carbon dioxide reduction technology, and relates to an oxygen-resistant photocatalytic reduction catalyst for carbon dioxide, its preparation method, and its application. The catalyst synthesis steps are as follows: Bi(NO3)3·5H2O is dissolved in a mixed solution of ethylene glycol and deionized water to obtain solution A; KBr is dissolved in ethylene glycol to obtain solution B. Solutions A and B are sonicated separately for half an hour, then mixed and transferred to a round-bottom flask, and stirred and heated at 100℃~200℃ for 1h~10h. After cooling to room temperature, the precipitate is collected by centrifugation, washed and soaked, and then heated and dried overnight to obtain BiOBr-V. O -X-ray photocatalyst. The BiOBr-V prepared in this invention O X-ray photocatalysts have high oxygen resistance, high catalytic efficiency and CO selectivity, and can use natural light as a light source to directly utilize CO2 in the air without further separation and purification.

The present application relates to the technical field of pharmaceutical equipment, and particularly relates to a kind of oscillation type reduced pressure distillation waterization equipment for preparing complex injection, such as micelle, liposome, microsphere and the like, which comprises: oscillation cavity, multiple partitions are arranged in the oscillation cavity, vibration device is arranged at the bottom of the oscillation cavity, for wave type or hinged plate type vibration of the oscillation cavity;Evaporation box, the evaporation box is the cavity structure arranged on each partition, the bottom of any one end is provided with a discharge interface, the top is connected with the vacuum feed pipe penetrating the outer wall of the oscillation cavity, the vacuum feed pipe is connected with the valve pipeline connected with the vacuum pump through the interface;In addition, the evaporation box is provided with a heater at the bottom.The present application uses multiple evaporation boxes to replace rotary evaporation round bottom flask, expands the one-time evaporation capacity, realizes the scale-up production of related pharmaceutical preparations in industrial production, forms ideal film layer at the bottom of the box by vacuum pump and heater, and also integrates the whole preparation method of film waterization into the equipment, avoids the risk of material pollution in transfer.

The application discloses a kind of anti-icing super-hydrophobic material preparation methods, with aluminum plate as substrate;First, blast furnace slag powder and steel slag powder are treated with hydrophobic modification, blast furnace slag powder and steel slag powder are mixed according to certain mass ratio, mixed powder and organic solvent A absolute ethyl alcohol are stirred in round bottom flask, after solution is fully mixed, organic solvent B seventeen fluorine decyl triethoxysilane is added and transferred to water bath heating tank water bath heating and stirring;Modified blast furnace slag-steel slag powder, organic solvent C butyl acetate are uniformly mixed according to 3:8 ratio, after reaction ten minutes, two-component polyurea is added drop by drop, and super-hydrophobic coating is obtained by drying.The present application uses blast furnace slag waste as main raw material, adds a small amount of steel slag to improve the wear resistance of coating, uses two-component polyurea as adhesive, uses modified-spraying two-step method, without large instrument equipment, and super-hydrophobic coating with excellent wear resistance is prepared simply and quickly.

The invention relates to the technical field of chemical preparation, in particular to a preparation method of gamma-thiocyano propyl triethoxy silane, which comprises the following steps: adding acetonitrile and tetrabutyl ammonium thiocyanate into a reaction container, dropwise adding 3-chloropropyl triethoxy silane into a four-mouth round-bottom flask while stirring, and controlling the dropwise adding time; the preparation method comprises the following steps: heating to 30-40 DEG C, reacting for 1.5-3 hours, cooling to room temperature, adding an ice-saturated sodium chloride solution into a reaction container to obtain a mixed solution, extracting the mixed solution, taking an organic layer, sequentially washing, drying and filtering, and respectively carrying out vacuum concentration and vacuum rectification on filtrate to obtain the gamma-thiocyano propyl triethoxy silane. The preparation method of the gamma-thiocyano propyl triethoxy silane provided by the invention is carried out under an anhydrous condition, so that hydrolysis and condensation side reactions of silane caused by a water-phase synthesis method are effectively avoided, meanwhile, the generation of irritant gases such as hydrogen sulfide and the like is avoided, and the preparation method is safer to operate, environment-friendly and more suitable for industrial popularization.

The invention belongs to the technical field of chemical analysis and detection. The invention provides a platinum complex fluorescent probe as well as a preparation method and application thereof in detection of water. The chemical formula of the platinum complex fluorescent probe is C23H16ClN3Pt; the preparation method comprises the following steps: 1, under the protection of argon, mixing terpyridine, potassium tetrachloroplatinate, deionized water and dimethyl sulfoxide in a round-bottom flask, heating, stirring, carrying out reflux reaction, cooling to room temperature, adding concentrated hydrochloric acid, carrying out suction filtration to obtain a precipitate, and drying to obtain Pt-Cl; 2, Pt-Cl, phenylacetylene, cuprous iodide, N, N-dimethylformamide and triethylamine are mixed into a round-bottom flask, then argon is pumped and replaced for multiple times, after a reaction, suction filtration is conducted, precipitates are obtained, washing and drying are conducted, and the catalyst is obtained. The platinum complex fluorescent probe is applied to detection of water and has the advantages of specific selectivity, high sensitivity, wide detection concentration range and the like, so that the detection can better meet the current requirements.

The invention discloses a green synthesis method for preparing micron spherical silver powder from green soybean pod extract. The green soybean pod extract is used as a reducing agent, and silver nitrate is used as a silver source. The preparation method comprises the following steps: cleaning, drying and crushing green soybean pods, putting the crushed green soybean pods into a round-bottom flask, connecting a reflux condensing tube, adding deionized water in a ratio of 1: 10, heating to boil, and keeping a reflux state for 1-3 hours; and after the reflux is finished, cooling the extracting solution, filtering to remove filter residues to obtain a green soybean pod crude extracting solution, carrying out ion exchange resin chromatography and water elution on the crude extracting solution to obtain a green soybean pod eluent, and carrying out vacuum concentration and drying to obtain the green soybean pod extract. Adding a dispersing agent into the silver nitrate solution, adjusting the pH value to 7, and then adding the mixed solution into the green soybean pod extract solution to obtain a mixed solution; and the mixed solution is magnetically stirred for 10 min, and then the micron spherical silver powder is obtained through high-speed centrifugation, xenon lamp irradiation, azeotropic distillation, washing and drying. The micron spherical silver powder prepared through the method is high in sphericity degree, good in fluidity and high in purity.

The application discloses a benzyl benzoyl or fluorinated alkane substituted phenol compound and a synthesis method and application thereof, and belongs to the technical field of drug synthesis. The synthesis method comprises the following steps: step one, 0.3mmol of o-aminobenzamide, 0.3mmol of ketone, 10mol% of I2 and 5mL of anhydrous ethanol are added into a 10mL round-bottom flask at one time, stirring is carried out at 80 DEG C for 24h, after the reaction is completed, the reaction liquid is poured into ice water, the volume ratio of the reaction liquid to the ice water is 1:10, ethyl acetate is extracted, the organic layer is washed with saturated brine, dried with anhydrous Na2SO4, and spin-dried to obtain a crude product. The synthesis method has the advantages of mild reaction condition, few side reactions and simple and convenient operation. And the benzyl benzoyl or fluorinated alkane substituted phenol compound obtained by the application has the effect of resisting colon cancer.

The application provides a preparation method of a multifunctional drug carrier, and the multifunctional drug carrier is curcumin-loaded nanoliposomes prepared by adopting a thin film dispersion method combined with dynamic high pressure microfluidization (DHPM), and the preparation method comprises the following steps: adding phospholipid, cholesterol, FA-F87, TPGS and curcumin into anhydrous ethanol for dissolving, transferring the solution to a 1000 mL round-bottom flask after the solution is completely dissolved to a clear state, and placing the solution on a rotary evaporator for removing ethanol by evaporation under reduced pressure to form a lipid film; the lipid film is hydrated under normal pressure at 45 DEG C for 30 min to obtain a curcumin coarse liposome solution; and the curcumin coarse liposome solution is treated twice by DHPM under the condition of 120 MPa to obtain the curcumin-loaded nanoliposomes; the curcumin-loaded nanoliposomes prepared by the application have good biocompatibility and stability, can improve the stability, solubility and drug release performance of a drug, and further improve the drug delivery effect and therapeutic effect of the drug.

The invention relates to the technical field of batteries, and discloses an electrolyte preparation method, an electrolyte, an ultrahigh-power lithium thionyl chloride battery and a manufacturing method. The method comprises the following steps: adding solid anhydrous gallium chloride and anhydrous lithium chloride into a round-bottom flask in an argon protection environment, and heating to melt the anhydrous gallium chloride and the anhydrous lithium chloride into liquid; after the round-bottom flask is cooled, thionyl chloride is added into the round-bottom flask and stirred to be partially dissolved, then chlorosulfonic acid is added so that transparent floccules can appear in the solution in the round-bottom flask, a condensation reflux device is installed on the round-bottom flask, and the round-bottom flask is heated so that the transparent floccules in the solution can be completely dissolved. The method comprises the following steps: adding a metal elementary substance lithium sheet into a round-bottom flask in an environment with the relative humidity of less than 1%, installing a condensation reflux device, heating to remove impurities in a solution, cooling the round-bottom flask, enabling sulfur dioxide to sequentially pass through a concentrated sulfuric acid and calcium chloride scrubbing device, and then introducing the sulfur dioxide into the round-bottom flask to remove moisture in the solution so as to prepare the electrolyte.

The invention provides a phosphate ammonium salt ionic liquid, a preparation method and application of the phosphate ammonium salt ionic liquid in a lubricating composition, cations of the phosphate ammonium salt ionic liquid are ammonium salt cations with different alkyl chain lengths, anions of the phosphate ammonium salt ionic liquid are phosphate with different chain lengths, and the preparation method of the ionic liquid comprises the following steps: adding alkylamine and phosphate into a round-bottom flask; and heating for 2-24 hours, and cooling to obtain the phosphate ammonium salt ionic liquid. The phosphate ammonium salt ionic liquid is used as a lubricant additive to be applied to a lubricating composition, so that the antifriction performance, the antiwear performance and the anti-rust performance of base oil are remarkably improved.

This application discloses a method for preparing a porous heterojunction vanadium-based aqueous zinc battery cathode and its application. First, FeCl3·6H2O and fumaric acid are dissolved in deionized water and stirred vigorously. The suspension is then transferred to a round-bottom flask for oil bath treatment. After cooling, the solution is washed and dried to obtain product MIL-88A. Next, NH4VO3 is dissolved in deionized water and stirred in an oil bath until completely dissolved. MIL-88A is dispersed in ethanol and added dropwise to the NH4VO3 solution with stirring. After cooling to room temperature, the solid product is centrifuged with water and ethanol respectively, and finally vacuum dried. The product is then heated using a muffle furnace to obtain a FeVO3 porous heterojunction oxide. This cathode material can reduce the zinc ion diffusion barrier, improve electron transport generated by the built-in electric field at the interface, and significantly improve its rate performance. The porous structure formed by its activation can reduce the diffusion barrier and improve the structural stability of the aqueous zinc battery cathode.

The invention discloses a cleaning device for improving the surface modification treatment quality of metal powder and a using method thereof.The device comprises a bottle burning plug, a cleaning rod body, a cleaning block and a side edge cleaning assembly, one end of the cleaning rod body penetrates through the bottle burning plug to be connected, and the other end of the cleaning rod body is connected with the cleaning block; a fixing strip is arranged on the side wall of the cleaning rod body and connected with the side edge cleaning assembly. The cleaning device suitable for cleaning the single-mouth / multi-mouth round-bottom flasks is simple in design structure and free of a mechanical transmission device, and the manufacturing cost can be greatly reduced. The device can achieve automatic and efficient cleaning without manual operation, when the device is used, only the upper portion of the cleaning rod body needs to be connected with the rotating speed regulator, the cleaning rod body can drive the cleaning brush and the cleaning block to continuously sweep while rotating, and therefore all-directional cleaning of the round-bottom flask is achieved. The device further has the advantages of being high in adjustability, good in adaptability and the like, and different types of cleaning requirements can be met.

The invention relates to the technical field of biological science, in particular to a synthetic method of hapten with glyphosate and alachlor structural characteristics. Comprising the following steps: dissolving alachlor in absolute ethyl alcohol in a clean and dry round-bottom flask to enable the concentration of alachlor to be 0.6 mol / l, stirring and clarifying, adding glyphosate and sodium hydroxide solids according to a molar ratio of 1: 1: 2, carrying out reflux reaction at 80 DEG C for 4 hours, monitoring by a TLC (Thin Layer Chromatography) method, and after no alachlor raw material is left, carrying out reduced pressure distillation to remove absolute ethyl alcohol to obtain the alachlor. Dissolving the residue in water, adjusting the pH value to 10 by using a 2mol / l sodium hydroxide solution, extracting by using ethyl acetate, supplementing the sodium hydroxide solution in each extraction, keeping the pH value to be more than 10 until the organic phase does not absorb ultraviolet light, adjusting the pH value of the water phase to 3 by using a 2mol / l hydrochloric acid solution, and extracting once by using ethyl acetate; the operation is simple, the post-treatment is easy, and the yield is high.

The application discloses a preparation process of a GSH ratio fluorescent probe, and specifically comprises the following steps: (1) raw materials 3-[3-(4-fluorophenyl)-1-isopropyl-1H-indole-2-yl]-propenal and dehydroacetic acid are placed in a 25 mL round-bottom flask, anhydrous DMSO is added as a solvent, and the raw materials are completely dissolved; (2) a catalytic amount of piperidine is added dropwise as a catalyst, and the reaction is carried out under N2 protection at 45±2 DEG C for 24 hours; after the reaction is completed, the color of the solution changes from the original blood red to dark red; (3) after cooling, dichloromethane and water are used for extraction, and finally, a dichloromethane / petroleum ether mixture is used as a developing agent to obtain a red crystal, which is used as a probe molecule 1 of the GSH ratio fluorescent probe. The application relates to the technical field of biological medicine, and specifically provides a preparation process of a GSH ratio fluorescent probe.

The application belongs to the technical field of polymer materials, and discloses a method for preparing a polyamide nanofiltration membrane based on a non-reactive ionic liquid, which comprises the following steps: preparation of a substrate PES membrane: 16wt% of polyethersulfone PES, 16wt% of polyethylene glycol PEG, and 68wt% of N-N dimethylformamide DMF are weighed and placed in a round-bottom flask, stirred in a water bath, and left to stand at the same temperature to remove air bubbles, then, the casting solution is cast on a glass plate with a steel knife and immersed in ultrapure water to remove residual solvent; preparation of a polyamide PA membrane: interfacial polymerization is performed on the PES membrane by using an aqueous phase solution containing piperazine PIP and 1-butyl-3-methylimidazole chloride and an oil phase solution containing TMC to synthesize a polyamide active layer. The application provides a new perspective for the regulation of monomer diffusion and reaction in the interfacial polymerization process, and has important application potential in the preparation of high-performance polyamide composite membranes.

The utility model relates to the technical field of pharmaceutical preparation engineering, and disclose a kind of electric doctor blade device based on profiled surface and negative pressure coordination, including the bottom end fixed connection of air pump main body is connected steel pipe, and the output end fixed connection of air pump main body is suction pipe.The utility model places installation block and scraping structure in the inside of medicine bottle by hand gripping rubber sleeve, then moves connection steel pipe and adheres steel bar scraper to the inner wall of medicine bottle, and the bottom end of steel bar scraper adheres to the round bottom of medicine bottle, at this time, rotating medicine bottle, under the action of steel bar scraper, the medicine on the inner wall of medicine bottle is scraped on the surface of steel bar scraper, and after scraping a certain amount, medicine can slowly fall into the inside of collecting groove, this design can make the arc of steel bar scraper more adhere to round bottom flask, enhance the contact area of steel bar scraper and the inner wall of medicine bottle, so that steel bar scraper can scrape most of the medicine in the inner wall of flask in the process of scraping, improve scraping efficiency.

A method and apparatus for detecting aluminum carbide content includes a right-angle tube I connected to a round-bottom flask via a rubber stopper I at its inlet. One end of the rubber tube I is connected to one port of a three-way valve, and the other two ports of the three-way valve are connected to rubber tubes II and III, respectively. The other end of the rubber tube II is connected to the gas inlet of a gas chromatograph. The other end of the rubber tube III is connected to the inlet of the right-angle tube II. The outlet of the right-angle tube II, a thermometer, and the inlet of the right-angle tube III are all embedded in the rubber stopper II and installed at the mouth of a specially designed measuring cylinder. The outlet of the right-angle tube III is connected to the inlet of the right-angle tube IV via a rubber tube IV. The outlet of the right-angle tube IV, along with a glass tube, is embedded in the rubber stopper III and installed at the mouth of a conical flask. By measuring the gas volume and composition sequentially through the three-way valve, the aluminum carbide content in the sample is determined using a function model. This allows for direct observation of changes during the detection process, effectively reducing operational errors and improving the accuracy of the detection results.

The invention discloses an extraction system capable of monitoring the temperature of extract liquor in real time, and belongs to the technical field of chemical experiment equipment. The system solves the problems of large deviation and inaccuracy caused by the fact that an existing Soxhlet extraction device adopts a single-neck round-bottom flask and cannot directly monitor the temperature of extract liquor and only indirect temperature measurement is adopted. According to the technical scheme, a multi-neck round-bottom flask is adopted to replace a single-neck flask, a first neck part of the multi-neck round-bottom flask is connected with an extraction tube, a second neck part is provided with a temperature sensor through a ground port, and a sensing part of the sensor extends into the flask and is immersed in an extraction solution. According to the system, thermal resistance of a bottle wall is avoided through direct contact type temperature measurement, accurate real-time monitoring is realized, and the system is used for accurately controlling heating, stabilizing temperature and improving efficiency and reliability in a chemical extraction experiment.

The utility model belongs to the technical field of round-bottom flasks, and provides a fixing frame suitable for round-bottom flasks of multiple models, which comprises a bottom plate, two non-adjacent side walls of the bottom plate are fixedly connected with supporting plates respectively, the side walls of the supporting plates are provided with transverse plates, the lower ends of the transverse plates are provided with clamping assemblies and limiting assemblies, and the side walls of the supporting plates are provided with locking assemblies; the rotary threaded column drives the first bevel gear through the second bevel gear, the rotary column and the two-way threaded rods at the two ends are driven to rotate, the clamping plates are made to be close to the bottle necks and clamped through the clamping blocks of the fixing assemblies, and the two round-bottom flasks with the bottle necks different in size can be stably clamped at the same time in cooperation with the springs; through the sliding connection design of clamping columns on the side wall of the transverse plate and first sliding grooves in the side wall of the supporting plate, the distance between the transverse plate and the bottom plate can be flexibly adjusted, the fixing requirements of round-bottom flasks with different heights are met, fixing can be completed only by rotating a threaded column, and the preparation time before an experiment is greatly shortened.

A scraping device for removing dry substances that have adhered to the interior surface laboratory vessel. The scraping device comprising a handle, a curved hook, a ribbed edge, an elbow joint, and a scraping tip. The hook part of the scraping device conforms to the curvature of the interior surface of a round laboratory vessel such as a volumetric flask, Florence flask, and round bottom flasks. The elbow joint of the scraping device enables hook portion to pass through the long narrow neck found in most laboratory vessels.

This invention relates to one-dimensional chain-like organometallic complexes grafted with imine-linked fluorescent groups, their preparation methods, and applications, belonging to the technical field of organometallic complex materials. The preparation method provided by this invention includes the following steps: S1, in a round-bottom flask, triazole ligands are coordinated with transition metal sulfates to obtain a series of one-dimensional chain-like organometallic complexes; S2, the one-dimensional chain-like molecules are dispersed in a solution, and the fluorescent group Bodipy is added. A Schiff base reaction occurs under an inert gas atmosphere and with the aid of a catalyst to obtain the one-dimensional chain-like fluorescent organometallic complexes. The method described in this invention is simple to operate, has a short reaction time, and exhibits higher stability compared to traditional organic fluorescent molecules, showing broad application prospects in chemical and biological sensing.

The invention belongs to the technical field of medicinal chemistry, and particularly discloses a derivative containing a 3, 4, 5-trimethoxy piperazine cinnamate structure and a preparation method and application thereof.The preparation method comprises the following steps that TMCA is dissolved in dichloromethane, and oxalyl chloride is added; then adding the mixture into a round-bottom flask filled with dichloromethane, 1-(t-butyloxycarbonyl) piperazine and N, N-diisopropylethylamine; after the reaction is finished, carrying out purification treatment to obtain an intermediate A; dissolving the intermediate A in dichloromethane, and adding a hydrogen chloride solution to obtain an intermediate B; dissolving the intermediate B in dichloromethane, adding benzoyl chloride and N, N-diisopropylethylamine, and after the reaction is finished, performing purification treatment to obtain a target product. The synthesis route of the target product is short and clear, meanwhile, the target product is a derivative with the function of resisting central nervous inflammation, and a certain research basis is provided for later application of the piperazine cinnamate derivative in the field of medicine.

The application relates to the field of coordination chemistry and provides a lead-based perovskite material, a preparation method and application, the chemical formula of the lead-based perovskite material is (C 10 H 11 N3)PbBr4, the lead-based perovskite material belongs to a monoclinic system, and the preparation method comprises the following steps: placing bis (4-pyridine) amine and lead bromide in a round-bottom flask, then adding hydrobromic acid, and then reacting under an oil bath at 373-393 K for 3 h; after standing, filtering, and cooling to room temperature, the lead-based perovskite material is obtained. The lead-based perovskite material with a second-order nonlinear optical effect, the preparation method and application, the lead-based perovskite material preparation operation is simple, energy consumption is low, easy to realize, reaction time is short, and the requirements for reaction and purity are low; and the lead-based perovskite material has a second-order nonlinear optical effect.

This invention relates to the production of a hybrid structure composed of ruthenium nanoparticles and an amine-functionalized network-interwoven co-polymer support material, which can be used in nanomaterials, catalysis, and energy storage systems, and its application in hydrogen energy production. Its characteristic feature is that 400 mg of amine-functionalized copolymer polystyrene is transferred to a two-necked round bottom flask, a solution is prepared by adding 10 ml of pure water, a ruthenium precursor salt is added to the solution, the mixture is stirred on a magnetic stirrer at 600 rpm at room temperature for 3 hours, 1.0 ml of aqueous 46.74 mg (1.23 mmol) NaBH4 solution is added to the solution for the reduction process, ruthenium(III) ions are reduced to metallic ruthenium(O) nanoparticles by NaBH4, the mixture is centrifuged at 6000 rpm for 10 minutes to separate the solid and liquid phases, the obtained solid product is washed three times with 20 ml of ethanol to remove remaining chemical residues, the purified hybrid catalyst is dried at 423 K under 0.1 bar vacuum for 12 hours, and the ruthenium / amine-functionalized copolymer PS catalyst is obtained and made ready for use, comprising these process steps.

The application provides a synthesis method of a C11a-OH tetracycline compound, which comprises the following steps: sequentially adding a polar solvent and a tetracycline raw material (1) into a round-bottom flask, slowly adding meta-chloro peroxide benzoic acid into the round-bottom flask at room temperature after stirring, removing the solvent by rotary evaporation under reduced pressure after reacting for 2 hours, and obtaining a target C11a-OH tetracycline compound (2) through reversed-phase preparation, and a reaction formula is as formula (II). (II) The synthesis method of the C11a-OH tetracycline compound is realized for the first time, the method is simple and efficient, has wide application range, and is easy to scale up.

The invention relates to the field of packaging film manufacturing, in particular to three siloxane in-situ reinforced degradable three-dimensional PLA films, a preparation method of the siloxane in-situ reinforced degradable three-dimensional PLA films comprises the following steps that S1, lactide monomers, silane and other raw materials are prepared; s2, adding a lactide monomer, fatty alcohol and an organic tin catalyst mixture into a three-necked round-bottom flask equipped with a mechanical stirrer and a vacuum pipeline in a glove box in an argon environment, vacuumizing the flask, flushing with dry nitrogen for 5 times, and then sealing in vacuum. Dehydrating and drying the reaction mixture at 120 DEG C under a vacuum condition to prepare a premix; and S3, immersing the flask into a preheated oil bath, synthesizing PLLA and PDLA through a ring-opening reaction, and heating the reaction mixture for several hours. And S4, dissolving the obtained product in dry chloroform, and carrying out precipitation recovery by using frozen methanol.

The utility model discloses a full-diameter rock core oil washing instrument which comprises a base, a lifting platform and a round-bottom flask, the three bases are arranged, supporting rods are connected to the tops of the three bases, and a top plate is arranged at the tops of the supporting rods. The lifting table is slidably connected to the surface of the supporting rod. A heating furnace is arranged on the top of the lifting table. The lifting platform is driven by the air cylinder to move, so that an operator can conveniently take out and put back a round-bottom flask to add and replace a reagent, complicated disassembly steps are not needed, the operation process is simplified, the operation time is saved, the labor intensity of the operator is reduced, and a large oil washing instrument is very convenient to operate; the volume of the sample chamber is large, the full-diameter rock core (the maximum sample diameter is 15 cm) and the small-diameter rock core plunger (the diameter is 2.5 cm or 3.8 cm) can be contained for oil washing, the maximum capacity is 25 L, more rock core samples can be processed, the overall efficiency of oil washing work is improved, frequent sample loading and unloading operation is reduced, and the oil washing device is suitable for large-scale rock core analysis work.

The invention discloses lipid vesicles co-loading salvia miltiorrhiza-radix puerariae effective components, a preparation method and application, and the preparation method comprises the following steps: placing egg yolk lecithin, sodium deoxycholate, radix puerariae isoflavone, tanshinone and salvianolic acid in a round-bottom flask according to a weight ratio of 50: (22-27): 10: (0.3-0.9): 7, then adding methanol for fully dissolving, carrying out rotary evaporation under the conditions of 40 DEG C and 50 rpm / min, filtering, washing, and drying to obtain the lipid vesicles. Removing methanol to obtain a film; performing vacuum drying overnight at room temperature to obtain a dry and transparent film framework; adding ultrapure water into the membrane skeleton, and carrying out hydration treatment to obtain a liposome solution; and filtering the liposome solution with a 0.22 [mu] m cellulose acetate membrane to obtain the liposome. Through multi-component synergistic encapsulation, strong hydrophobic tanshinone is encapsulated in a phospholipid bilayer, weak hydrophobic pueraria isoflavone is distributed on a phospholipid layer or interface, and hydrophilic salvianolic acid is contained in a water phase or interface, so that the stability of a lipid vesicle system is enhanced, and the problem of low bioavailability of a preparation is solved.

The invention relates to a preparation method of pH and GSH dual-response cyclodextrin nanoparticles. The preparation method comprises the following steps: S1, preparing a 10mg / mL lecithin absolute ethyl alcohol solution; s2, a DSPE-PEG 2000-UM206 solution with the concentration of 9 mg / mL is prepared; s3, preparing a water phase; s4, preparing an organic phase; and S5, nano-precipitate self-assembly: in a round-bottom flask, rapidly magnetically stirring the water phase at room temperature, dropwise adding the organic phase into the water phase at a speed of less than 1 mL per minute, and stirring at room temperature for 2 hours. And S6, purification of the nanoparticles: transferring the solution into a 30 kDa ultrafiltration tube, centrifuging for 20 minutes at 4000 * g, and cleaning with PBS for 3 times to obtain the acetalated disulfide bond beta-cyclodextrin dimer nanoparticles. When the pH and GSH double-response cyclodextrin nanoparticle prepared by the preparation method of the pH and GSH double-response cyclodextrin nanoparticle is used for delivering HHT, the pH and GSH double-response cyclodextrin nanoparticle has a sensitive pH / GSH double-response function and an efficient tumor killing effect, has a good treatment effect on OCSCs, can give full play to the tumor killing effect of the HHT, and also can effectively reduce the drug side effect of the HHT.