193 results about "Perfusion" patented technology

The utility model discloses automatic filling equipment for syringes. Comprising a filling rack, a tray sliding plate horizontally and linearly installed on the filling rack in a sliding mode, a tray positioning mechanism used for braking and positioning trays in tray containing grooves in the tray sliding plate, a tray feeding and discharging mechanical arm used for feeding and discharging the tray containing grooves, and a sliding plate driving device used for driving the tray sliding plate to slide intermittently. The device comprises a tray sliding plate, a filling mechanism used for filling liquid medicine into a row of injectors in a tray located on the tray sliding plate, a rubber plug feeding mechanism used for placing rubber plugs at the opening ends of the row of filled injectors, a rubber plug pressing mechanism used for pressing the rubber plugs into the injectors by set depth, a manipulator used for controlling feeding and discharging of the tray, and a tray positioning mechanism. The automatic filling device for the rubber plug is compact in structure, small in occupied space, high in filling efficiency of the injector and capable of preventing the rubber plug from being damaged when the rubber plug is pressed.

The application discloses a double-channel nephropyeloscope, which comprises a first shell and a second shell, the first shell and the second shell are buckled to form a containing cavity, a base seat is arranged on the top of the cavity of the first shell, an instrument socket is arranged on the base seat, an instrument inlet is arranged on the end of the instrument socket away from the base seat, a perfusion recess is arranged on the base seat, an outer pipe joint is arranged on the front end of the perfusion recess, an inner pipe clamping sleeve is arranged on the rear end of the perfusion recess, a negative pressure four-way joint is arranged on the side of the inner pipe clamping sleeve away from the outer pipe joint, an insertion pipe and an instrument channel pipe are arranged on the negative pressure four-way joint and are connected with the perfusion recess, the instrument channel pipe is arranged close to the inner pipe clamping sleeve, the insertion pipe is arranged on the side of the negative pressure four-way joint away from the instrument channel pipe, and the insertion pipe, the instrument channel pipe, the inner pipe clamping sleeve, the perfusion recess and the outer pipe joint are coaxially and throughly connected. The application provides a double-channel nephropyeloscope which can realize negative pressure suction, perfusion and pressure measurement simultaneously.

The application relates to the field of medical image assisted ablation technology, and provides a thyroid nodule ablation control system based on ultrasound contrast parameters. The system comprises an ultrasound data acquisition module, a contrast parameter analysis module, a blood supply identification module, an ablation strategy generation module, an ablation execution module, a feedback evaluation module, a closed-loop control module and an energy optimization module. By acquiring an ultrasound contrast image of target tissue, perfusion time, perfusion intensity and perfusion sequence parameters are extracted, blood supply arteries or blood supply areas are identified, and a phased ablation strategy is generated, the blood supply area is preferentially ablated, and then main ablation is carried out on the target tissue; at the same time, residual active areas are detected based on contrast feedback, and supplementary ablation is carried out through a closed-loop control mechanism; and ablation parameters are dynamically optimized in combination with a unit volume energy model. The system can improve ablation integrity, reduce the heat sink effect and the risk of intraoperative bleeding, reduce the recurrence rate, and improve energy utilization efficiency.

The application discloses a light adjustment monitoring method based on retinal blood flow velocity and related equipment, and belongs to the technical field of data processing. Wherein, the method comprises: acquiring baseline blood flow parameters of a user, the baseline blood flow parameters comprising: average flow velocity, baseline blood vessel density and baseline perfusion density; the baseline blood flow parameters are extracted from a baseline retinal blood flow image of the user, the baseline retinal blood flow image being collected before outputting adjustment light to the retina of the user; during the process of outputting adjustment light to the retina of the user, real-time retinal blood flow images of the user are repeatedly collected at a preset time interval; real-time blood flow parameters are extracted from the real-time retinal blood flow images; a blood flow adjustment degree value is determined according to the real-time blood flow parameters and the baseline blood flow parameters; and the output power of the adjustment light is adjusted according to the blood flow adjustment degree value.

The present application relates to cell preparation process in the field of bioengineering, disclose a kind of high-efficiency preparation mouse primary hepatocyte method, comprising: perfusion needle is placed in reverse direction to liver direction through inferior vena cava, utilize the blood vessel clamp with elastic micro-tooth damping surface to lock the perfusion needle and inferior vena cava wall;The overflow damping of hepatic portal vein outflow end is dynamically regulated by blood vessel clamp, to construct controlled positive pressure permeation environment in liver vascular bed;Collagenase solution is radially permeated to liver parenchyma using the environment, the present application makes enzyme solution radial deflection and cross blood sinus barrier into di's cavity by constructing micro-pressure environment, eliminate the digestion dead zone originally due to flow path preference, ensure that enzyme molecule and extracellular matrix are uniformly contacted in global dimension, realize the collaborative promotion of tissue cutting efficiency and total amount of cell release, ensure that the output cell population has highly consistent physiological state.

The application discloses a multifunctional antibacterial coating bone implant device based on a selective vacuum perfusion process and a preparation method thereof. The method comprises the following steps: 1) pretreating a titanium alloy base; 2) performing anodic oxidation treatment on the pretreated titanium alloy base to construct a nanotube structure on the surface of the titanium alloy base; 3) selectively coating the treated titanium alloy base with a hydrogel adhesive, then immersing the titanium alloy base in a povidone iodine mixed solution to perform vacuum perfusion, and performing post-treatment, then again performing selective coating, immersing the titanium alloy base in a solution containing a bone growth promoting factor to perform vacuum perfusion, and performing post-treatment, then again performing selective coating, immersing the titanium alloy base in a solution containing a blood vessel growth promoting factor to perform vacuum perfusion, and performing post-treatment; and 4) encapsulating the obtained sample surface with an in-situ self-polymerized polydopamine layer, washing and freeze-drying. The bone implant device has antibacterial, bone growth promoting and blood vessel growth promoting functions, and can greatly improve the curative effect on bone fracture symptoms accompanied by infection.

The present application relates to a TAVR teaching model based on blood flow simulation and multi-modal image fusion and use method. The model comprises a simulated thoracic and abdominal cavity with a built-in heart wave beat simulation part that drives fluid to generate pulsatile blood flow, a simulated thoracic and abdominal body with pre-set vascular access, a bionic heart assembly with structures such as a ventricular cavity, a pathological valve module that can be detachably fitted to the aortic valve ring and contains a pressure sensor array and simulated calcification, a coronary circulation monitoring module that monitors the perfusion state of the coronary artery opening, a virtual fluoroscopy positioning module that generates real-time fluoroscopy images, and a central control console that electrically cooperates with each module. The scheme simulates the tactile sensation of calcification through the pathological valve module, the heart wave beat simulation part reproduces the physiological pressure difference with a closed loop blood flow, realizes image navigation training with non-radiation virtual fluoroscopy, integrates real-time simulation of complications with coronary monitoring and annulus pressure sensing, and solves the problems of existing models such as distorted hand feeling, inaccurate dynamics, dependence on radiation, and lack of complication training.

The invention relates to a perfusion module (10, 40, 70) for a bioreactor, comprising a main body (12, 42, 72) having a fluid passage (18, 48, 78) and a recess (20, 50, 80) inclined toward said fluid passage (18, 48, 78), a filter element (14, 44, 74), and at least one fastening element (16, 46, 76, 76a, 76b), wherein the at least one fastening element (16, 46, 76, 76a, 76b) is designed to fasten the filter element (14, 44, 74) to the main body (12, 42, 72), wherein, when the perfusion module (10, 40, 70) is in an assembled condition, the fluid passage (18, 48, 78), the recess (20, 50, 80) of the main body (12, 42, 72) and the filter element (14, 44, 74) together form a flow-permeable cavity (28, 58, 83).

The present application relates to the technical field of peritoneal dialysis, in particular to a multi-bag independent control and intelligent circulation system of peritoneal dialysis equipment. The present application determines the correction residual amount based on the basic backflow residual amount and the basic perfusion residual amount adjusted by the flushing effect of the backflow of waste liquid, and the weight change of each drug liquid bag before and after dialysis circulation and the theoretical ultrafiltration amount. The characteristic correction residual amount is determined based on the state parameter difference of each drug liquid bag dialysis cycle and several dialysis cycles before it. The target flushing amount after each drug liquid bag dialysis cycle is determined based on the characteristic correction residual amount and the concentration gradient difference of the adjacent two circulation drug liquids, and the next drug liquid bag output target flushing amount is controlled to flush the pipeline with the drug liquid, and the generated flushing waste liquid is guided to the previous drug liquid bag to start the next drug liquid bag dialysis cycle. The present application realizes dynamic and accurate quantification of pipeline residual, combines physical correction and personalized habit calibration, and improves the pipeline flushing effect.

Disclosed in the present invention are a disposable continuous oxygenation mechanical perfusion circulation system for ex-vivo organs and a working method. A circulation pipeline of the circulation system is provided with a deoxygenated return line and an oxygenated perfusion line; an output end of a low-temperature organ storage container is connected to the deoxygenated return line, and a pump tube and an oxygenator are arranged in the deoxygenated return line; an organ adapter sleeve assembly is detachably mounted on an organ tray assembly; the organ tray assembly is arranged in a cavity of the low-temperature organ storage container; and an output end of the oxygenator is connected to the oxygenated perfusion line, an automatic bubble separator mounted on the oxygenated perfusion line is connected to an input end of the organ adapter sleeve assembly, and a pressure sensor is mounted on the oxygenated perfusion line. The present invention has the following advantages: the ability to provide an automatic bubble removal function; having an oxygenation function in addition to a low-temperature mechanical perfusion function; being lightweight and being convenient for portable transport of a perfusion apparatus; and having higher safety and reliability.

The perfusion tube includes a sidewall defining an interior chamber having an expandable volume, a connector associated with a proximal end of the sidewall and configured to reversibly engage an outlet of a fluid reservoir containing a medical fluid, and a closure associated with a distal end of the sidewall, the closure being permeable to air but substantially impermeable to the medical fluid. The expandable volume of the interior chamber is configured to increase as the medical fluid enters the interior chamber.

The utility model discloses an ophthalmic cavity instrument multi-channel cleaning frame, specifically relates to ophthalmic cavity instrument cleaning technical field is equipped with the connecting pipe, and the connecting pipe includes: rigid fixed head, is connected on the connecting pipe, and the faraway connecting pipe one end is equipped with the help suction connecting portion, is used for with the help suction hole detachable connection of injection suction handle, the elastic hose is equipped in the side of rigid fixed head, and the front end is equipped with perfusion connecting portion, is used for with the perfusion hole sealed connection of injection suction handle. The utility model through setting up rigid fixed head on the basis, the elastic hose is installed in the side, realizes the one side channel of cavity instrument and is fixed in rigid fixed head place, and the other side uses the butt joint of elastic hose and connects, realizes double channel simultaneous flushing, guarantees the cleaning effect of instrument cleaning, also reduces the manual work of staff, improves the work efficiency.

This document discloses compositions and methods involving glycosaminoglycan components. For example, administering a composition comprising a glycosaminoglycan component to an organ before, during, or after ex vivo organ perfusion can improve organ transplantation. These improvements include reduced MMP levels, reduced apoptosis markers, reduced endothelial cell activation, and increased organ function. Such methods and compositions can be used for organ and tissue transplantation, as well as for the storage or transport of acquired organs and tissues.

The present invention relates to an ophthalmic ultrasonic emulsification sleeve for confirming intraocular and extraocular penetration and perfusion, which allows determining whether aqueous humor communication between the inside and outside of the eye is smooth through a microtube implanted in the eye during glaucoma tube surgery. The sleeve is characterized by having a rigid branch tube made of a material harder than a sleeve made of a soft material, provided in a perfusion port that allows the injection of a balance salt solution into the eye, and with the branch tube connected to the perfusion port, the tip of the branch tube protrudes further than the tip of the Paco tip, and the end of the microtube inside the eye is connected to the tip of the branch tube, so that the establishment of aqueous humor communication of the microtube can be quickly and accurately and sensorially confirmed based on the pattern of pressure change in the conjunctival area and surrounding blood flow change that occurs when the balance salt solution leaks out of the eye.

The present application relates to vitrectomy technical field, specifically disclose a kind of accurate oil exchange method and its control system in minimally invasive vitrectomy, to the problems of mutual interference, intraocular pressure fluctuation, artificial push and team cooperation caused by the same channel shared by silicon oil injection and perfluorocarbon liquid suction in prior art, the present application is physically connected by three-way component silicon oil catheter and the silicon oil perfusion control interface of vitrectomy equipment, using gas-liquid exchange air pump to provide continuous stable air pressure power source, to drive silicon oil injection with constant working pressure;At the same time, by the single manual control of surgeon suction path, according to visual observation real-time adjustment suction speed, realize the independent double-channel control and dynamic balance of silicon oil injection and perfluorocarbon liquid suction.The present application is based on the high viscosity of silicon oil and the stable voltage characteristics of air pressure power source, significantly improves the accuracy, stability and safety of operation, reduces the operation difficulty and team cooperation dependence.

The application provides a placenta perfusion and fetal development prediction method and system based on ultrasound images, and relates to the technical field of medical image analysis and diagnosis, which comprises the following steps: obtaining a placenta ultrasound image and pre-processing and quality control; segmenting the placenta region through a deep neural network, extracting multi-dimensional features of gray scale, texture, shape and blood flow; inputting a machine learning model to predict the perfusion and fetal development state; visualizing the results and key factors, combining clinical verification and generating intervention suggestions. The system comprises image processing, segmentation, prediction, visualization and verification interpretation modules. The application realizes objective quantitative evaluation, solves AI problems, forms full-chain clinical support, improves early warning accuracy, helps precise intervention and reduces perinatal risks.

The application discloses a brain hemorrhage perioperative medication scheme intelligent recommendation method and system, acquires physiological parameters and operation time sequence characteristics of a patient, constructs a patient risk image, carries out risk matching with a drug knowledge base to generate a candidate drug set, extracts drug attribute characteristics to determine a drug function grouping, carries out adaptability scoring based on the patient risk image to generate a grouping adaptability matrix, carries out drug interaction analysis to identify synergistic pairs and antagonistic conflict pairs, carries out combination optimization on the synergistic pairs to generate a synergistic scheme, carries out conflict exclusion screening on the antagonistic conflict pairs to generate safety constraints, constructs a medication scheme topology, carries out dose sensitivity anomaly detection and correction to generate a correction factor to generate a time-sharing drug administration scheme, carries out real-time monitoring to carry out perfusion evaluation to determine a safety level and trigger dose adjustment, forms an optimized medication scheme, and realizes intelligent recommendation of perioperative medication.

Systems and methods are provided for reducing the reliance on operator skill during vascular ultrasound procedures. The placement of an ultrasound probe to assess perfusion associated with a wound may be facilitated by receiving input suitable for identifying an anatomical region associated with the wound and providing an indication of a suitable initial probe position, and optionally, probe orientation, for acoustically interrogating a target arterial vessel known to provide perfusion to the anatomical region associated with the wound. Regions exhibiting arterial flow may be detected as the probe is moved, enabling arterial vessel detection and localization. A subregion within the detected arterial vessel and a beam steering angle may be autonomously determined for spectral Doppler data collection, enabling the measurement of hemodynamic measures associated with the arterial vessel. Example apparatus for securing the probe to the patient and facilitating probe positioning to search for a target vessel are disclosed.

Provided herein are novel reprogrammed smooth muscle cells (rSMCs) and methods of making and using the cells for the treatment of ischemia. The rSMCs are produced by culturing a fibroblast with an all-trans-retinoic acid (ATRA) under conditions that produce the rSMC from the fibroblast, wherein the fibroblasts are genetically modified to overexpress myocardin. The rSMCs offer advantages over currently available regenerative vascular therapies by promoting vascular perfusion in a recipient subject. In particular, the rSMCs can increase neovascularization of both small and large vessels.

This specification provides a cardiac ultrasound coronary artery stenosis diagnostic system and method based on a visual language transfer model. The system includes: a database construction module for standardizing multi-view cardiac ultrasound video sequences and radiological reports; a cardiac region of interest (ROI) standardization and labeling module for segmenting myocardial segments, obtaining ROI data, and generating a coronary artery-specific perfusion region mask as the ROI for vascular-level stenosis prediction; a visual language transfer pre-training module for semantic alignment of video data and report text using a visual language transfer model; and a downstream task prediction module for utilizing the enhanced attention mechanism of the coronary artery-specific perfusion region mask, based on the global visual features output by the visual language transfer pre-training module, to output patient-level classification results for obstructive coronary artery disease and vascular-level stenosis prediction results for LAD, LCX, and RCA.

The utility model discloses a ureteral flexible mirror belongs to medical instrument technical field, including handle shell, one end of handle shell is rotatively connected with joint, the outside fixed connection of joint has mirror body sleeve, the other end fixed connection of handle shell has first channel pipe, the end of first channel pipe is communicated with first sheath pipe channel, first sheath pipe channel sets up inside handle shell, the inside fixed connection of handle shell has connecting block, and one end of first sheath pipe channel is inserted in the inside of connecting block, the utility model discloses a first channel pipe and second channel pipe are set up, better satisfy clinical treatment demand, when perfusion physiological saline maintains clear vision and operation space, another channel carries out operation, guarantees operation visual field clear, avoids the tissue damage because of visual field fuzzy, improves the operation convenience, solved the single problem of existing ureteral flexible mirror working channel.

This invention discloses a skin organ-on-a-chip, relating to the fields of biomedical engineering and microfluidics. The chip includes a drive module integrating a reservoir with a fixed height difference, a culture layer with arrayed independent skin culture units, and a fluid layer separated by a porous membrane. The drive module utilizes the hydrostatic pressure generated by the liquid level difference to drive the culture medium to form a stable laminar flow in an optimized fluid channel network, achieving pump-free perfusion. This invention achieves stable pump-free drive through a reservoir with a fixed height difference; the integrated sealed structure eliminates the risk of contamination and ensures complete isolation between units; the simulation-optimized uniform flow channel network, in synergy with the drive, ensures high consistency in high-throughput parallel culture, enabling the chip to provide a long-term stable biomimetic perfusion microenvironment. A single experiment can efficiently complete multiple replicates and multi-condition transdermal drug screening, toxicity testing, and disease model construction, improving experimental throughput, data reliability, and ease of operation.

This invention discloses a xenogeneic bone repair scaffold and its preparation method. The preparation method of the xenogeneic bone repair scaffold includes: a pretreatment step: obtaining bone blocks cut from animal bones, decellularizing, washing, and calcining to remove organic components to obtain a basic framework; a perfusion molding step: providing a mixed slurry of collagen, bioactive tricalcium phosphate, and a cross-linking agent, perfusing it into the basic framework under negative pressure vacuum, and freeze-drying to obtain a pre-formed composite xenogeneic bone; and a secondary cross-linking step: immersing the composite xenogeneic bone in a cross-linking agent for secondary cross-linking, and freeze-drying to obtain the xenogeneic bone repair scaffold. This xenogeneic bone repair scaffold completely removes immunogenic substances from the xenogeneic bone material while maintaining excellent water absorption and wetting properties to promote the regeneration of new bone and blood vessels.

The present application relates to the technical field of medical first-aid monitoring, in particular to a cardiopulmonary resuscitation instrument continuous electroencephalogram monitoring and feedback method based on pattern recognition, comprising: real-time acquisition of original electroencephalogram signal flow and pressing waveform data flow, cutting out complete phase electroencephalogram signal units synchronized with pressing cycles after electroencephalogram signal artifact elimination, generating dynamic frequency spectrum sequence through transformation; extracting key frequency spectrum mode chain quantifying cerebral energy metabolism state, aligning and fusing with pressing depth and frequency trajectory time, constructing brain-machine coupling dynamic correlation atlas; identifying brain blood supply benign and malignant trajectory fragments, generating brain perfusion risk trend index, combining with pressing parameter deviation degree to generate instant correction instruction. The method can realize accurate synchronization coupling of electroencephalogram signal and pressing action, reflect brain perfusion changes in real time, form a closed-loop feedback of electroencephalogram monitoring and pressing parameter regulation, and guarantee the synergy of brain function monitoring and pressing regulation in the cardiopulmonary resuscitation process.

The application relates to an air intake detection device, method, ventricular assist system, storage medium and equipment for a ventricular assist device, which comprises a pressure detection module, a data processing module and an air intake judgment module, wherein the pressure detection module is configured to detect pipeline pressure during perfusion; the data processing module is configured to determine a pressure difference in at least one sampling period, the sampling period starts at the beginning of a variable-speed operation and ends at the end of the variable-speed operation; the air intake judgment module is configured to perform air intake detection according to the sampled pipeline pressure data in the sampling period; and the air intake judgment module is further configured to judge that air intake exists in the pipeline when the pipeline pressure and / or the pressure difference meets preset air intake judgment conditions.

The present invention relates to systems and methods for post occlusion surge mitigation and ophthalmic surgical systems. According to certain embodiments, a surgical cassette for an ophthalmic surgical system includes a perfusion conduit in fluid communication with a handpiece and delivering fluid to a surgical site. An aspiration conduit is in fluid communication with the handpiece and carries fluid away from the surgical site. An aspiration pump generates a vacuum pressure in the aspiration conduit to direct fluid through the aspiration conduit toward a drain reservoir. A reservoir is coupled to a pressure-vacuum source to manage the reservoir pressure. A valve is in fluid communication with the aspiration conduit and the reservoir and provides one or more passageways between the aspiration conduit and the reservoir. Each sensor detects a pressure associated with the surgical site. A computer controls the valve in response to the pressure detected by one or more of the pressure sensors to reduce pressure variations or volume variations.

This invention discloses a traditional Chinese medicine composition for improving diarrhea, belonging to the field of traditional Chinese medicine technology. Addressing the shortcomings of existing antidiarrheal techniques, which only treat the symptoms and not the root cause, have significant side effects, high recurrence rates, and easily cause damage to the intestinal microcirculation, this invention is based on the original microscopic pathogenesis of small intestinal microvascular spasm and ischemia, and abnormal intestinal fluid metabolism. It is prepared by combining peppermint, angelica dahurica, nutmeg, cinnamon, platycodon grandiflorus, and angelica sinensis. The synergistic effect of each herb can target and relax spasmodic small intestinal microvessels, restore normal intestinal blood perfusion, regulate intestinal peristalsis rhythm, bidirectionally regulate intestinal fluid secretion and reabsorption, and simultaneously block abnormal stress signals in the brain-gut axis, repairing intestinal microcirculatory damage. This invention has a scientifically formulated composition, mild medicinal properties, and no side effects. It addresses the root causes of various acute, chronic, and functional diarrheas caused by cold stimulation, emotional stress, and spleen deficiency with cold stagnation, exhibiting strong curative effect and an extremely low recurrence rate, possessing high clinical promotion and application value.