1675 results about "Perfusion" patented technology

A system for perfusing an organ, for example a kidney or a heart. Preservation fluid can be pumped from a transport container to the organ through a cannula or organ adapter. A flow regulator valve can control the rate of flow of the preservation fluid based on renal resistance of the kidney or arterial resistance of the organ. The pump can operate at a rate independent of the arterial resistance.

Systems and methods are disclosed for processing medical images. One method includes: receiving a patient-specific vessel model of one or more vessels of a patient and a patient-specific tissue model of a tissue supplied by the one or more vessels, wherein the patient-specific vessel model and the patient-specific tissue model are derived from the medical images of the patient; determining one or more patient-specific values of one or more anatomical or physiological parameters based on the patient-specific vessel model or the patient-specific tissue model; determining an estimated supplied blood to the tissue; computing an estimate of a perfusion of blood in the tissue based on the determined patient-specific values of the one or more anatomical or physiological parameters and the determined estimated supplied blood to the tissue; generating a visualization of the computed estimate of the perfusion of blood; and displaying the estimate of the perfusion on an electronic display.

The invention provides an acute cerebral apoplexy early-stage intelligent screening and early warning method and system based on deep learning, and relates to the technical field of medical imaging and artificial intelligence, and the method comprises the steps: obtaining a multi-temporal angiography image of the brain of a patient through a pulse-type dynamic imaging scheme, extracting hemodynamic features through a double-flow feature extraction network, and obtaining a multi-temporal angiography image of the brain of the patient; and constructing a vasculopathy risk distribution diagram by combining a vascular structure analysis model, and marking a potential embolism risk area. Furthermore, in combination with tissue perfusion parameters obtained by multispectral imaging and brain tissue function parameters obtained by electroencephalogram signals, an ischemic penumbra region is identified by using a self-adaptive threshold segmentation model. And finally, based on the ischemic penumbra area, the tissue perfusion parameters and the brain tissue function parameters, calculating a risk level by using a hierarchical decision model with a space-time attention mechanism, and generating a corresponding clinical intervention scheme. According to the invention, the early accurate screening and risk early warning of acute cerebral apoplexy can be realized, and the clinical intervention efficiency is improved.

Systems and methods are disclosed for to determining a blood supply and blood demand. One method includes receiving a patient-specific model of vessel geometry of at least a portion of a coronary artery, wherein the model is based on patient-specific image data of at least a portion of a patient's heart having myocardium; determining a coronary blood supply based on the patient-specific model; determining at least a portion of the myocardium corresponding to the coronary artery; determining a myocardial blood demand based on either a mass or a volume of the portion of the myocardium, or based on perfusion imaging of the portion of the myocardium; and determining a relationship between the coronary blood supply and the myocardial blood demand.

A normothermic perfusion circuit can be used to perfuse a donor heart after transportation and before transplantation. The circuit can drain the organ storage container of cold preservation solution, perfuse the aorta of the heart with warm fluid to initiate heart activity, and then perfuse the left atrium of the heart with warm fluid to bolster heart activity and evaluate heart viability. Heart viability can be determined using parameters measured by sensors in the circuit.

A normothermic perfusion circuit can be used to perfuse a donor heart after transportation and before transplantation. The circuit can drain the organ storage container of cold preservation solution, perfuse the aorta of the heart with warm fluid to initiate heart activity, and then perfuse the left atrium of the heart with warm fluid to bolster heart activity and evaluate heart viability. Heart viability can be determined using parameters measured by sensors in the circuit.

A persistent perfusion sheath assembly can be used for the passage of an intravascular medical device while maintain a flow passage in the vessel. The sheath assembly passes through an arteriotomy and can include a first lumen configured for the passage of a medical device, a second lumen configured to allow a flow of fluid from a location in the blood vessel upstream of the arteriotomy to a location downstream of the arteriotomy. The sheath assembly can further include a stylet, a sleeve or an additional sheath configured to selectively open and close the flow of blood between upstream and downstream of the arteriotomy. The sheath assembly can further include a closure device distal of the arteriotomy, the closure device configured to control blood flow through the arteriotomy.

The invention provides a vascularized organ-like chip based on seal microstructure patterning and a preparation method thereof, the chip comprises a micro-channel layer, the upper surface of the micro-channel layer is provided with a gel perfusion channel, a central tissue chamber and culture medium flow channels at two sides which are connected, and tumor spheres or colon cells are inoculated in the central tissue chamber; the liquid storage pool layer is arranged on the upper surface of the micro-channel layer and corresponds to the inlet and outlet of the gel filling channel, the inlet and outlet of the central tissue chamber and the inlet and outlet of the culture medium runner, the liquid storage pool layer is provided with a plurality of liquid storage pools and a plurality of through holes, and the liquid storage pools contain culture solutions to provide nutrients for cultured tissues; and the seal module is arranged above the central tissue chamber, the seal module is provided with a tumor seal and a colon seal, and the tumor seal and the colon seal are respectively provided with a microstructure three-dimensional module and are respectively used for simulating the culture environment of tumor spheres or colon cells. According to the invention, in-vitro construction of the vascularized tumor model and the colon model is realized, and a guide is provided for construction of the vascularized organ-like model with specific organ three-dimensional microstructure characteristics.

Balloon catheters, sleeves, cages, cylindrical structures and endoluminal prostheses are provided with stress-applying and spacing features coupled to expandable surfaces thereof. At least one or at least some stress-applying features are immobilized onto the surface or into pre-formed indentations formed in the expandable surface. The stress-applying and spacing features may have blunt and / or rounded contact regions which contact tissue or calcified regions in the vasculature. The contact regions dent or fracture occlusive material on the wall of a vascular lumen and / or patient valve leaflets when expanded. The spacing of features can permit blood, drug, and contrast perfusion past structures expanded in the vasculature, particularly balloon catheters.

Embodiments of the invention include additional methods and compositions for fabricating organoids. A unique approach has been developed for the rapid aggregation of defined number of cells using a micropillar-based template to limit the size of organoids, which are then more commonly referred to as spheroids. This procedure can be utilized to create in vitro cardiac tissue models (e.g., cardiac organoids) simply, rapidly, and inexpensively. In certain aspects an alginate-gelatin based hydrogel premixed with cardiomyocytes is used in combination with a patterned microfluidic chip / cell culture chamber having an array of micropillars to fabricate 3D cardiac organoids.

The invention discloses a stroke prognosis prediction method and system, and the method comprises the steps: S1, obtaining a CTP image of a whole cerebral vessel; and S2, the CTP image is segmented, and the segmented CTP image is obtained. And S3, carrying out feature extraction on the segmented CTP image to respectively obtain morphological features of whole cerebral vessels, perfusion features of an infarction core region and blood flow difference features of key blood vessel points. And S4, constructing a stroke prognosis prediction model based on machine learning according to the morphological characteristics of the whole brain blood vessels, the infarct core region perfusion characteristics and the blood flow difference characteristics of the key blood vessel points. According to the method, the blood flow and perfusion characteristics of the blood vessel are extracted more comprehensively, finely and quantitatively, and the whole method and system are full-automatic and do not need manual participation.

The present disclosure relates to balloon assemblies designed to permit blood flow through a central perfusion channel, at least when blood flows in a proximally-oriented direction. Such a balloon assembly can include one or more toroid balloons, each defining a cavity that can be independently fed by one or more inflation tubes coupled thereto to inflate the balloon. When the toroid balloons are inflated within a patient lumen or a prosthetic device, such as a prosthetic heart valve, blood is allowed to flow through the perfusion lumen. A balloon assembly can further include a flexible valve configured to regulate blood flow when the balloon assembly is inflated, to allow proximally directed flow through a channel formed in a flexible funnel thereof, and prevent backflow in the opposite direction.

The invention relates to the technical field of medical care, and provides a patient risk dynamic assessment system in medical care teaching, which comprises a data acquisition module used for acquiring multi-modal image data of a postoperative gastric organ anastomosis area of a patient; the data processing module is used for preprocessing the multi-modal image data, establishing a three-dimensional model of organs around the anastomotic stoma and analyzing edge features of the anastomotic stoma; and the risk assessment module is used for constructing an anastomotic stoma state assessment model and outputting comprehensive scores of an anastomotic stoma blood perfusion condition, a tissue metabolism abnormal probability, an anastomotic stoma leakage risk, anastomotic stoma scar hyperplasia and healing trend prediction. A quantum dot fluorescence image, a Raman spectrum image, a CT image and an intraoperative high-definition white light image are enhanced through the system and evaluated, a nursing scheme is obtained in combination with opinions of medical staff, and compared with manual evaluation of the medical staff, the accuracy is higher, the feasibility of the nursing scheme is higher, and medical nursing use is facilitated.

The invention relates to medical instruments, in particular to a peritoneal dialysis device which comprises a dialysate management unit, a sensor unit, a processor, a storage device, a peritoneal transfer model, an intelligent alarm management unit and a communication unit, and the dialysate management unit is configured to be used for perfusion of dialysate into the abdominal cavity of a patient and drainage of the dialysate from the abdominal cavity of the patient; the sensor unit is configured to be used for monitoring physiological parameters of a patient and dialysate characteristic parameters and receiving symptom information and comfort level scores input by the patient, the storage stores instructions executed by the processor, and the instructions enable the processor to be capable of dynamically adjusting treatment parameters of the dialysate management unit in real time in combination with a pre-trained peritoneal transfer model. The perfusion speed, the drainage speed or the dialysate temperature of the dialysate management unit are dynamically adjusted, so that the comfort level score of the patient is maintained to be above a preset threshold value, treatment parameters can be dynamically adjusted in real time to optimize the treatment effect, peritonitis risks are early warned, and the comfort level of the patient is improved.

The organ chip comprises a culture membrane and an actuating membrane, a first culture chamber, a second culture chamber, an actuating chamber and a perfusion channel are further formed in the organ chip, the culture membrane divides the first culture chamber and the second culture chamber, the perfusion channel is communicated with the first culture chamber, and the actuating chamber is communicated with the second culture chamber. A communication port of the perfusion channel and the first culture chamber faces the culture membrane, preferably directly faces the culture membrane, the perfusion channel is used for connecting an external air source, the actuating chamber separates the second culture chamber and the actuating chamber, and the actuating chamber can deform in response to a pressure change of the actuating chamber so as to conduct the pressure change between the actuating chamber and the second culture chamber; further, the culture membrane is deformed. The organ chip can more truly simulate the respiratory movement process of pulmonary alveoli and the multi-directional shear stress generated by gas to cells, and is beneficial to meeting the research requirements of respirator-related lung injury.

The embodiment of the invention provides an emergency data quality control analysis method and device based on big data. Wherein a microcirculation dynamic mapping model with time-space correlation is constructed and integrated through a nanofiber sensing array of the flexible electronic skin device. And performing time reference synchronous compensation and space coordinate transformation mapping on the model and spatio-temporal data of emergency treatment monitoring equipment to form a fusion data field, thereby realizing joint feature distribution of microcirculation parameters and emergency treatment parameters. The fused data field is subjected to mode coupling verification with a microcirculation compensation track map in a shock compensation mode feature library through a dynamic quality control engine, and when it is detected that mode mismatching exists between a parameter evolution path and a historical track, space-time signal fragments are reconstructed based on phase features and space distortion features; and generating a quality control report associated with the abnormal skin perfusion gradient node. According to the technical scheme provided by the embodiment of the invention, the quality control effect of the emergency data of the shock patient is improved.

The invention provides a pourable tumor organoid vascularization model and a construction method thereof, and relates to the technical field of organoid culture. A temperature-sensitive degradable material and a photo-crosslinking modified temperature-sensitive material are used, the composite stent is printed through two channels, a multi-component gel mask partition curing process is combined, the stability of a perfusion pipeline is improved, and a partitioned highly-bionic complex microenvironment is accurately constructed in a macroscopic three-dimensional space; and constructing to obtain the perfusion tumor organ vascularization model. The model is high in bionic degree and stable in structure, can be applied to deepening cell and microenvironment interaction research and tumor-related drug screening, and has a good application prospect.

A method or use for managing one or more acute ischemic events. The method can include determining criteria of a clot; classifying the clot based on the criteria and generating a classification; determining an individualized treatment protocol for the clot based on the classification, the individualized treatment protocol comprising one or more techniques selected from using aspiration, restoring perfusion using a first reperfusion device, and / or restoring perfusion using a second reperfusion device; and treating the clot based on the individualized treatment protocol.

The present invention belongs to the field of organoid chips. Provided is a multiple-organoid co-culture micro-fluidic chip, comprising organoid micro-fluidic chip cells, each organoid micro-fluidic chip cell being divided into an upper layer and a lower layer which are bonded to each other, the upper layer being sequentially provided with an organoid culture medium perfusion channel, a first channel barrier, an organoid culture chamber, a second channel barrier and a vascular endothelial culture channel, and the lower layer being provided with a micro-perfusion network channel. The chip ensures specific nutrition and microenvironment for each organoid and helps to maintain specific phenotypes for same. In addition, the chip can simulate in-vitro blood flowing, so as to perform signal communication and interaction between organoids, thereby fully simulating the in-vivo environment and interaction for multiple-organ diseases.

A tissue analysis system and method process hyperspectral images to classify tissue types within the images. A presence or level of tissue oxygenation is estimated for each tissue type as well as a PPG perfusion. The estimated tissue oxygenation and PPG perfusion information are combined to provide a tissue status for each tissue type. The system and method uses remote PPG sensing.

The invention provides a ring-type continuous blood pressure measurement and perfusion measurement system and equipment, and the system comprises a signal collection module which is used for collecting a photoelectric signal of a finger part of a user, a pressure signal of an air bag and a skin temperature signal; the signal processing module is used for calculating continuous blood pressure and perfusion values according to the collected photoelectric signals of the finger parts, the pressure signals of the air bags and the skin temperature signals, and measuring information of the user is obtained; and the data storage module is used for storing the measurement information of the user and realizing data extraction. According to the invention, continuous blood pressure measurement and perfusion measurement are combined with synchronous measurement, and the measurement precision of blood pressure measurement based on a volume compensation method in a low perfusion state is improved.

The present disclosure provides methods and systems for treating tumors with radiotherapy, wherein a first dose of radiation is administered to a first sub-volume of the tumor and a second dose of radiation is administered to a second sub-volume of the tumor.

The invention relates to the technical field of tumor biomedical engineering and organ chips, in particular to a vascularized gastric cancer organ chip and a preparation method thereof.The chip is composed of an integrated micro-fluidic main body, an annular micro-column array and an optical sealing film, and a central culture cavity is divided into a tumor area and a blood vessel area by micro-columns; the preparation method comprises the following steps: injecting a fibrous protein solution containing human umbilical vein endothelial cells and cancer-related fibroblasts into a vascular region, and adding thrombin for in-situ gelation to form a pre-vascularized network; the method comprises the following steps: mixing a patient-derived gastric cancer organ with a methacrylic acid esterified gelatin pre-polymerized solution, injecting the mixture into a tumor area, and carrying out photo-crosslinking immobilization; culturing for 7-14 days under the dynamic perfusion condition of a mixed culture medium to obtain a three-dimensional gastric cancer organ model containing a capillary network; the method is expected to be used for rapid, low-cost and high-throughput screening of chemotherapy or anti-angiogenesis drugs and accurate prediction of individual curative effects of patients.

An aorta intervention catheter device for heart failure comprises a catheter and a bag body arranged at one end of the catheter, an elastic diaphragm is arranged in the bag body, an inner cavity of the bag body is divided into a blood chamber and an air chamber by the elastic diaphragm, the blood chamber is communicated with the catheter, an exhaust assembly is arranged on the bag body, and the air chamber is connected with an air source connector arranged on the bag body; the other end of the catheter is a proximal end, first guide films which are staggered at intervals and inclined towards one side of the proximal end and second guide films which are inclined towards a distal end are arranged on the inner wall of the catheter, and first guide holes and second guide holes which correspond to the first guide films and the second guide films and are communicated with an inner cavity of the catheter are respectively formed in the outer wall of the catheter; the proximal side of the second guide film is provided with at least one set of third guide films which are fixed to the inner wall of the catheter, incline towards the distal end and are tightly attached to each other to be closed. The aorta is directly intervened to enter the heart, and coronary artery blood perfusion is increased in the diastolic period; the left ventricular post-load is reduced in the systolic period, and the heart failure can be more directly treated.

The invention relates to the technical field of medical instruments, and discloses a pedal control type urinary surgery ureteroscope perfusion pressure pulse adjusting device which is characterized in that the piston head in the middle of three groups of piston heads is inserted into a liquid injection cavity, and the piston heads on the two sides are inserted into a pressure cavity; the three sets of piston heads can inject liquid and high-pressure gas into the control valve cavity from the liquid injection cavity and the pressure cavity. A pedal control mechanism is innovatively introduced, a worker treads a pedal frame in a reciprocating mode, controls liquid to clean a lens and flushes broken stones in a matched mode, the rhythm of treading flushing can be better controlled through autonomous reciprocating treading of a doctor, the situation that an assistant needs to repeatedly use an injector and an extension tube for pushing injection in a traditional urinary surgery is avoided, and the working efficiency is improved. The problems that doctors need to be frequently matched with nurses, the examination concentration of the doctors is easily affected are solved, operation is more efficient, and the problem that the injectors are repeatedly replaced is solved.

The invention provides a real-time processing method for endoscopic image blood vessel enhancement and microcirculation evaluation, which comprises the following steps of: processing an original endoscopic image, and locally enhancing a brightness channel through a contrast-limited adaptive histogram equalization technology; self-adaptive frequency domain-space domain decomposition is realized based on local texture complexity analysis; performing multi-scale Hessian matrix blood vessel detection on the low-frequency component; applying a directional Gabor filter bank to the high-frequency component; spatial-temporal feature fusion is realized through multi-resolution pyramid optical flow calculation; synchronously completing blood vessel probability prediction, blood vessel diameter estimation and blood flow direction prediction by using a lightweight multi-task deep learning network; the blood flow velocity is analyzed and calculated based on a speckle mode, the perfusion density is subjected to accelerated statistics through an integrogram, and vascular morphological parameters are extracted by adopting an improved skeleton algorithm. According to the invention, an enhanced blood vessel visualization effect and a real-time microcirculation quantitative evaluation function can be provided, and the overall improvement of the endoscope image processing quality and efficiency is realized.

The invention discloses a perfusion laser balloon catheter and a balloon catheter system, the perfusion laser balloon catheter is provided with a far end and a near end which are opposite to each other, and the perfusion laser balloon catheter comprises a guide wire and a balloon catheter, the inner tube is fixedly arranged on the periphery of the guide wire in a sleeving mode, the far end of the inner tube is blocked by the blocking piece, the inner tube is provided with a medicine channel, and a first outlet communicated with the medicine channel is formed in the far end of the inner tube; the optical fiber extends along the inner tube, and the far-end part of the inner tube is provided with a light-emitting section; the balloon body is located on the periphery of the inner tube, and the far end of the balloon body is connected with the outer wall of the inner tube in a sealed mode; the first outer tube is located on the periphery of the inner tube and communicated with the near-end side of the balloon body, and a radial gap between the first outer tube and the inner tube serves as a fluid channel for inflating the balloon body. According to the perfusion laser balloon catheter, medicine can be better released, the uniformity of light emission is guaranteed, and therefore the treatment effect on vascular diseases is improved.

A method of describing fluid dynamics in a tissue or organ using a numerical model of blood flow is provided. In one aspect, the invention relates to a method for assessing myocardial perfusion in a human patient using non-invasive measurements and percolation mechanics including computational fluid dynamics. The method may be implemented as a computer-implemented invention. The method includes using patient-specific anatomical structure data obtained from the non-invasive measurements to generate an anatomical geometric model of the myocardium connected to the plurality of coronary vessels. The anatomical geometric model is a combination of fluid and porous domains and boundaries thereof. The invention eliminates the deficiencies of known in vivo methods, including all risks associated with invasive procedures. Furthermore, an actually infinite temporal-spatial resolution is achieved, the result of the invention is completely free of motion artifacts, and the exposure of the patient to radiation is limited.

The invention belongs to the field of biological medicine, and provides a protection liquid capable of preserving in-vitro animal organs or in-vitro animal tissues at normal temperature as well as a preparation method and application of the protection liquid, and the protection liquid comprises a solution containing a hemoglobin oxygen carrier or a hemoglobin carrier, an osmotic pressure regulating substance and the like. The protective liquid provided by the invention can be used for preserving or perfusing broken limbs, isolated animal organs or isolated animal tissues at normal temperature, and can also be used as a culture liquid of artificial organs and artificial tissues.

The invention relates to the technical field of a preparation method of a determination kit for in-vitro determination of adiponectin in a human body, and particularly discloses a preparation method of a determination kit for in-vitro determination of adiponectin in a human body, which comprises the following steps: a coupling process; an S-shaped bent pipe is installed on the side connector, an upper connector is kept in an open state, a perfusion device adds 0.3-0.4 volume of a sealing buffer solution into the glass bottle, and 0.1-0.2 volume of the sealing buffer solution is injected into the glass bottle through an injection connector; and a storage process: closing the filling interface, opening the cover body, installing the up-down extending pipe, covering the cover body, opening the filling interface, carrying out resuspension ultrasonic treatment by using the storage buffer solution, and carrying out centrifugal washing for three times, thereby finally obtaining the adiponectin latex antibody. The device is easy and convenient to operate, simple in structure, independent of the manual control level and high in preparation efficiency, the situation that materials are left in a small-size glass bottle, consequently, the material ratio is difficult to control, and a small amount of confining liquid is needed is avoided, and the prepared adiponectin latex antibody is good in accuracy.