11 results about "High signal intensity" patented technology

An image processing method includes: a step of creating, by a blood vessel mask creation unit, a blood vessel mask image by removing a punctate low signal intensity, removing a linear low signal intensity, extracting the linear low signal intensity, removing a punctate high signal intensity, removing a linear high signal intensity, and extracting the linear high signal intensity from an image obtained from a magnetic resonance signal intensity in which a region corresponding to a blood vessel is enhanced with respect to an MRI image; and a step of generating, by a mask processing unit, an image in which a blood vessel structure is removed using the blood vessel mask image from a phase difference enhanced image created from the MRI image.

The invention is suitable for the technical field of magnetic resonance imaging, and provides a radio frequency field non-uniformity correction method and device, electronic equipment and a program product. The method comprises the following steps: acquiring actual radio frequency field intensity of each position in a scanning object under two preset radio frequency field intensities and actual CEST signal intensity at a first chemical shift position and a second chemical shift position; determining a first ideal CEST signal intensity based on the actual radio frequency field intensity of the same position under the two preset radio frequency field intensities and the actual CEST signal intensity at the first chemical shift; determining a second ideal CEST signal intensity based on the actual radio frequency field intensity of the same position under the two preset radio frequency field intensities and the actual CEST signal intensity at the second chemical shift; and determining the GluCEST signal intensity based on the two ideal CEST signal intensities at the same position under the target radio frequency field intensity. According to the invention, the accuracy of GluCEST signal strength measurement can be improved.

The invention discloses a space metabonomics analysis method and application thereof, relates to the technical field of metabonomics analysis, and solves the problem that an analysis result of an existing conventional space metabonomics analysis method is not accurate enough. To-be-analyzed biological tissue samples are taken and divided into groups; preparing all groups of samples into slices, adsorbing the slices on the same glass slide, carrying out mass spectrum imaging detection, and synchronously collecting metabolite spatial distribution signals and mass spectrum intensity data of all the samples; the method comprises the following steps: preprocessing collected original data, identifying the distribution condition of known exogenous components in a medicine in a tissue slice, and delimiting a region with high signal intensity as a region of interest; randomly selecting a plurality of pixel points in the region of interest of each sample; and integrating the mass spectrum data corresponding to the pixel points selected from all the parallel samples in the same group, and sequentially carrying out PCA, OPLS-DA, differential metabolite screening and KEGG pathway enrichment analysis. The method can be applied to research on the hepatotoxicity of the polygonum multiflorum and the prepared polygonum multiflorum.

The application is suitable for the field of magnetic resonance imaging technology, and provides a radio frequency field inhomogeneity correction method and device, electronic equipment and program product. The method comprises the following steps: acquiring actual radio frequency field intensity of each position in a scanning object under two preset radio frequency field intensities, and actual CEST signal intensity at a first chemical shift and a second chemical shift; determining a first ideal CEST signal intensity based on the actual radio frequency field intensity of the same position under the two preset radio frequency field intensities and the actual CEST signal intensity at the first chemical shift; determining a second ideal CEST signal intensity based on the actual radio frequency field intensity of the same position under the two preset radio frequency field intensities and the actual CEST signal intensity at the second chemical shift; and determining a GluCEST signal intensity based on the above two ideal CEST signal intensities of the same position under a target radio frequency field intensity. The application can improve the accuracy of GluCEST signal intensity measurement.

A photoacoustic spectroscopy system is provided, comprising an acoustic cell, an electromagnetic radiation unit, and a resonant transducer unit. The acoustic cell includes a resonant cavity supporting a first resonant mode having a first resonant frequency, and to which a sample fluid can be supplied. The resonant transducer supports a second resonant mode having a second resonant frequency and is functionally connected to the resonant cavity. The first and second resonant modes are configured to be coupled in a significant coupling region, and the adjustment of the first and second resonant modes is configured to result in an increase in signal intensity or signal-to-noise ratio.

This disclosure provides a technology for improving images that are obtained by in situ hybridization of gene transcripts. A set of target probes specific for different target nucleic acids in a sample are adapted to include a common landmark sequence. After binding to the sample, the target probes are optionally amplified, and then specifically identified using labeled detector readout probes. The copy of the landmark sequence in each of the target probes, or amplification products generated therefrom, is identified using a labeled landmark identification probe. Image spots generated from the labeled detector readout probes are compared with image spots generated from the landmark identification probe to see if they correspond. Detector spots having no corresponding landmark spot are removed from the final image. When implemented with LISH Lock'n'Roll hybridization methodology, the probes generate a higher signal intensity with a better signal-to-noise ratio.

An image processing method includes: a step of creating, by a blood vessel mask creation unit, a blood vessel mask image by removing a punctate low signal intensity, removing a linear low signal intensity, extracting the linear low signal intensity, removing a punctate high signal intensity, removing a linear high signal intensity, and extracting the linear high signal intensity from an image obtained from a magnetic resonance signal intensity in which a region corresponding to a blood vessel is enhanced with respect to an MRI image; and a step of generating, by a mask processing unit, an image in which a blood vessel structure is removed using the blood vessel mask image from a phase difference enhanced image created from the MRI image.

The present invention relates to the field of optical microscopy, and more particularly to a spectral microscopy system and method for measuring the unsaturation distribution of oils and fats. The spectral microscopy system comprises a femtosecond laser, a first optical path component, a second optical path component, a beam combining optical path component, a CARS signal optical path component, and an image generation module. By introducing a half-wave plate and a quarter-wave plate into the optical path, the two beams required to generate the CARS signal are modulated into circularly polarized light with opposite rotational directions. The CARS spectrum intensity is calibrated using the non-resonant signal of pure water as a reference, thereby achieving the effect of measuring the unsaturation distribution of oils and fats. This method has the advantages of high signal intensity, low background noise, fast detection speed, high resolution, and non-destructiveness. It not only accurately measures the unsaturation of oils and fats, but also enables two-dimensional or three-dimensional microscopic imaging for detailed analysis of the unsaturation distribution in the sample. Furthermore, it can significantly improve the accuracy and efficiency of oil and fat quality analysis.

The invention relates to the field of quarantine detection, and discloses a high-robustness and high-signal-intensity digital immunodetection kit and method.The kit comprises an inert nucleic acid sealing agent and a nucleic acid embedding dye; the inert nucleic acid sealing agent is coated on the surface of the solid phase carrier or contained in the rolling circle amplification reaction liquid; the nucleic acid intercalation dye is contained in the rolling circle amplification reaction liquid, and the emission spectrum of the nucleic acid intercalation dye is compatible with the emission spectrum of the sequence specific probe with the fluorescence label. Strong and uniform signals can be converted into accurate quantitative results only by depending on accurate single magnetic bead counting. And meanwhile, the flow design difficulty is also reduced by clear signal separation, so that the single magnetic bead analysis in the presence of the sealing agent is simpler and more reliable. Through the combined action of the two, the kit is especially suitable for stable and accurate quantification of the extremely low abundance protein marker in a complex clinical sample.

The invention provides a local dynamic enhanced visual muon imaging method based on magnetic focusing. The method comprises the following steps: after muons are focused, receiving muon signal data of a small area through a detector; preprocessing the muon signal data of different angles in the same area to obtain a projection data set; performing imaging reconstruction on the projection data set by adopting a three-dimensional reconstruction technology; and obtaining the three-dimensional density distribution of the target area. According to the invention, the multi-stage superconducting solenoids or quadrupole iron are utilized to actively regulate and focus muons, so that the signal intensity is greatly improved, the imaging period is greatly shortened, and the imaging quality is improved; by controlling the magnetic field intensity and direction of the multistage superconducting solenoids, the muon flux from a specific direction can be selectively enhanced, directional imaging is realized, and the imaging speed is improved by 5-8 times; by alternately irradiating the target, multiple groups of complementary projection data are obtained, the problem of projection missing in traditional muon imaging is improved, and the sampling rate of three-dimensional reconstruction is improved by more than three times.

The invention relates to the technical field of gene engineering, in particular to a circulating in-situ hybridization method for detecting RNA (Ribonucleic Acid) in tissue. According to the invention, a microfluidic system is not needed, the cover glass is treated and coated, the tissue slice is attached to the coated cover glass, the probe hybridization pool is attached to the periphery of the tissue, and a closed device for hybridization reaction is provided. The method comprises the following steps: carrying out in-situ hybridization on RNA sites by using lock-type probes, connecting the lock-type probes hybridized to correct sites into a ring through ligase, amplifying the lock-type probes connected into the ring by using a rolling circle amplification technology, converting an RNA signal into a single-stranded DNA signal and simultaneously completing signal amplification, and enabling each lock-type probe to contain a unique barcode base sequence, the method is used for combining with a fluorescent probe to detect RNA of a corresponding bar code sequence. The method is high in signal intensity, collection of fluorescence signal points does not depend on a super-resolution imaging platform and a microfluidic system, and multi-gene in-situ detection which is low in cost and easy to operate can be achieved.