342results about "Raman scattering" patented technology

The application discloses a preparation method of a VP@UiO-66-NH2 / Ag NPs composite SERS chip and application thereof in A beta protein detection, and is characterized by comprising the following steps: synthesizing a VP-graphite paper base by a chemical vapor transport method on a surface of a graphite paper to obtain a VP-graphite paper base; synthesizing a UiO-66-NH2 layer on the surface of the VP-graphite paper base by a solvothermal method to obtain a VP@UiO-66-NH2 composite base; and finally, placing the composite base in an ion sputtering instrument, uniformly sputtering silver nanoparticles on the surface of the composite base, taking out the composite base, and obtaining the VP@UiO-66-NH2 / Ag NPs composite SERS chip, wherein the VP@UiO-66-NH2 / Ag NPs composite SERS chip has the advantages of high sensitivity, good stability and uniformity, controllable preparation process, low cost, application in Alzheimer's disease biomarker detection, high specificity in identification and quantitative analysis of A beta 40 and A beta 42 proteins, fast response and good stability.

This invention discloses a multi-functional optical microscopy imaging system that integrates multiple imaging techniques, including fluorescence lifetime imaging, bright-field microscopy, Raman microscopy, and one sample manipulation technique, optical tweezers, in a single microscope setup. This allows for the acquisition of structural, functional, and molecular information from the sample with simultaneous sample manipulation function. Various design approaches have been outlined for a multi-modality microscopy by segmenting the entire operational wavelength range of an objective lens into separate spectral channels, each dedicated to a specific optical technique.

The present disclosure provides a method for characterizing a nanostructure comprising illuminating the nanostructure with a Raman spectroscopy laser at a first power level sufficient to generate significant free charge carriers, acquiring a first Raman spectrum, illuminating the nanostructure at a second power level lower than the first power level wherein the second power level generates negligible free charge carriers, acquiring a second Raman spectrum, and determining at least one material property based on a difference between the first and second Raman spectra. The nanostructure may comprise a nanosheet field effect transistor having a superlattice of alternating Silicon and Silicon- Germanium layers with each layer having thickness less than 10 nanometers. The material property may comprise strain, Germanium composition, free charge carrier lifetime, or diffusion properties.

The application relates to the field of micro-nano optical mechanical and electrical technology, and particularly relates to a SERS micro-fluidic chip and a manufacturing method thereof. The SERS micro-fluidic chip comprises a SERS substrate and a micro-fluidic chip, the SERS substrate is connected to the output channel end of the micro-fluidic chip, the input end of the micro-fluidic channel is used for inputting a sample solution to be detected, and the SERS substrate is a porous silicon carbide substrate. The SERS substrate is manufactured by using a porous silicon carbide material, and automatic adsorption of silver nanoparticles is realized by using an electrochemical deposition method, so that a Raman enhancement substrate can be manufactured, the manufacturing process is simple, the processing efficiency is high, the preparation cost is low, the repeatability is good, the stability is high, and the SERS activity is high; and the micro-fluidic chip can realize rapid, efficient, high-sensitivity and high-throughput differential detection on different concentrations of substances.

This invention belongs to the field of SERS detection technology and relates to the application of an Ag / Bi4O5Br2 / Ni-Fe double hydroxide composite SERS substrate in the detection of CV in wastewater. First, a Bi4O5Br2 / Ni-Fe double hydroxide is prepared, and silver nanoparticles are loaded onto its surface using a liquid-phase chemical reduction method. This material combines the LSPR effect of silver nanoparticles with the interfacial coupling and multiple active sites of the Ni-Fe double hydroxide, enabling the regulation of interfacial charge transfer and enhancing molecular adsorption. Utilizing the excellent adsorption and enrichment properties of Bi4O5Br2, a highly efficient charge transport system is synergistically constructed from multiple components, improving the SERS chemical enhancement effect and amplifying the CV Raman signal. This invention overcomes the shortcomings of weak signals and insufficient stability of single substrates, achieving sensitive detection of trace CV in water. The substrate preparation process is simple, environmentally friendly, and highly practical, showing broad application prospects in the field of trace CV analysis in aquatic environments.

The present disclosure relates to a method for sorting a metal- comprising object in a stream of metal-comprising objects, the method comprising measuring contamination levels over a surface of the metal-comprising object. The method further comprises locating at least one point on the surface where the contamination level is below a threshold level and directing a laser beam at the at least one point to locally form a plasma and measuring a spectrum of the plasma; or directing a laser beam at the at least one point to form an optical signal comprising a plurality of Raman wavelengths and measuring a spectrum of the Raman wavelengths. The method further comprises assigning a class to the metal-comprising object, based on the measured spectrum, and sorting the metal- comprising object into one of a first output fraction (A) or a second output fraction (B), based on the assigned class.

A computer-implemented method and system are provided. An analytical instrument support system receives a first spectra dataset associated with scans of one or more first samples, the one or more first samples including a target analyte having one or more known levels of a parameter. The analytical instrument support system receives a second spectra dataset associated with scans of one or more second samples. The analytical instrument support system determines one or more spectra arrays by combining (i) the first spectra dataset and (ii) the second spectra dataset. The analytical instrument support system determines a chemometric model for one or more levels of the parameter of the target analyte based on, at least, the one or more spectra arrays and the one or more known levels of the parameter.

The application discloses a gallium oxide single crystal growth impurity detection and analysis method based on Raman spectrum detection, relates to the technical field of semiconductor crystal detection and analysis, and comprises the following steps: generating an impurity traceable directed propagation graph based on a time sequence Raman spectrum data set containing spatial coordinates, deducing and screening a candidate impurity migration path, integrating a hierarchical impurity distribution and evolution network, obtaining a main defect cluster of impurities through physical segmentation, carrying out cross-growth cycle impurity concentration diffusion inversion on each defect cluster, quantifying an impurity contribution weight, and generating a structured detection and analysis report in combination with a crystal growth process database. The method constructs an impurity propagation relationship based on space-time spectrum data, realizes quantitative screening of a migration path and fine inversion of a defect cluster, accurately defines the contribution degree of impurities in different growth stages, and provides a complete analysis path for gallium oxide single crystal growth impurity detection.

The application discloses a kind of real-time detection method and system of food pollutant based on intelligent sensor, comprising: through the multimodal sensor array of deployment in food processing production line key station, sensor response signal is collected;Baseline response under the condition of no pollution is predicted by establishing dynamic baseline prediction model;Signal separation network based on variational decoupling autoencoder is constructed, residual signal is mapped to low-dimensional latent space by sharing encoder and is divided into baseline error subspace and pollutant signal subspace, respectively by two independent decoders reconstructing baseline prediction error signal and pollutant candidate signal;Multi-scale time-frequency transform is carried out to pollutant candidate signal to identify pollutant type and estimate concentration;Through distributed intelligent agent cooperation, pollution traceability and hierarchical early warning are carried out;Cross-scene adaptive calibration is realized using meta-learning framework.The application realizes the real-time decoupling of pollutant signal and matrix change signal in food processing process.

The application discloses a multi-peak decomposition time-resolved Raman spectrum thermal map interactive analysis method and system, and belongs to the field of spectrum analysis. The method comprises the following steps: continuously or time-divisionally collecting a to-be-measured sample to obtain Raman spectrum data corresponding to different time points; preprocessing the original Raman spectrum data; extracting spectral characteristic peaks by using an adaptive peak value recognition algorithm, and performing characteristic peak integral calculation; obtaining time contribution coefficients of different chemical components or characteristic signals in the time dimension by using a multi-peak decomposition algorithm; generating a Raman thermal map in the time dimension according to the characteristic peak intensity and / or the time contribution coefficients; establishing an index mapping relationship between the position of the Raman thermal map and the corresponding time Raman spectrum data; and responding to the interactive operation of the user on the thermal map and displaying the Raman spectrum curve at the corresponding time point in real time. The application can realize visual display, dynamic monitoring and interactive analysis of time sequence data of Raman spectrum, and improves the efficiency and accuracy of Raman signal analysis of dynamic samples.

The invention belongs to the technical field of micro-nano machining, and particularly relates to a hollow metal nano array and a preparation method and application thereof. According to the invention, a regular polymer nano array is prepared based on an ultraviolet light curing nano imprinting technology and a plasma etching technology; then metal evaporation is carried out in combination with an electron beam evaporation dip angle evaporation process, so that the surface of the polymer nano array is partially coated with metal, and a polymer / metal composite nano array with a notch is obtained; and dissolving by using a solvent to remove the water-soluble polymer nano-columns in the polymer / metal nano-array with the notches, so as to prepare the large-area hollow metal nano-array of which the morphology, the size and the period can be flexibly designed. Sulfydryl benzaldehyde molecules are fixed on the surface of the hollow metal nano array to form an SERS (Surface Enhanced Raman Scattering) substrate which is used for detecting hydrazine hydrate. The SERS substrate prepared on the basis of the hollow metal nano array shows high sensitivity, specificity, repeatability and stability.

A liquid (2) measurement chamber extension (10) for spectrophotometric characterization of a liquid (2) in a polymer container (3) by a NIR spectrophotometer (1) or a Raman spectrophotometer (1), the measurement chamber extension (10) comprising an adapter plate (11) having an adapter opening (11'); a container holder (7); and an optical element (5) selected from a mirror and a waveguide; the adapter (11) is configured to cover a measurement chamber (20) of the NIR spectrophotometer (1) or the Raman spectrophotometer (1) in a light-tight manner, the adapter opening (11') surrounding a measurement window of the NIR spectrophotometer (1) or the Raman spectrophotometer (1) to allow the NIR spectrophotometer (1) or the Raman spectrophotometer (1) to measure the spectrophotometric characterization of the liquid (2) in the polymer container (3). a measurement chamber extension (10) configured to provide exposure of the liquid (2) to a measurement light beam emitted from a measurement chamber (20) of a spectrophotometer (1) through the measurement window; the container holder (7) configured to bring the optical element (5) in close proximity to the polymer container (3) containing the liquid (2) to provide loss-free transmission or transflective of the measurement light beam from the optical element (5) to a detector of the NIR spectrophotometer (1) or the Raman spectrophotometer (1), the container holder (7) comprising a clamp (13) configured to hold a tubular section (3a) of the polymer container (3) to enable reproducible measurement conditions.

The application discloses a sludge ozone coupling catalytic oxidation treatment test system, which comprises an oxygen generator, an ozone fission device, a micro-nano bubble generating device, a sludge feeding device, an ozone catalytic oxidation reaction kettle, an online Raman spectrum detection device and an ozone concentration online monitoring device; the oxygen generator, the ozone fission device and the micro-nano bubble generating device are sequentially connected, the micro-nano bubble generating device is connected with a micro-nano bubble aeration device; the sludge feeding device is connected with a sludge feeding nozzle; the online Raman spectrum detection device performs non-contact detection on the transparent ozone catalytic oxidation reaction kettle through a high-precision laser probe with a laser signal source, and transmits a signal to a Raman online detector for analysis and calculation; and the ozone concentration online monitoring device is used for online monitoring of the ozone source concentration. The application integrates high-concentration ozone generation, micro-nano bubble mixing, catalytic oxidation reaction and online detection functions, and can realize multi-dimensional data acquisition and process controllability in the sludge wall breaking process.

A rapid formaldehyde content detection device for hair products, relating to the field of formaldehyde detection technology, is used to achieve rapid and accurate detection of formaldehyde in hair products while meeting the requirements of convenience. The rapid formaldehyde content detection device for hair products includes a housing, an optical detection system, a sample processing system, an electronic control system, a software system, and a transparent detection tube. The housing is rectangular, with three drawer-style compartments inside: the upper compartment is the optical detection system compartment, the middle compartment is the electronic control system compartment, and the lower compartment is the sample processing and storage compartment. Shock-absorbing rubber pads and metal supports are installed between the optical detection system compartment and the electronic control system compartment, and between the electronic control system compartment and the sample processing and storage compartment. The bottom of the housing has binding straps for securing it, and the side of the housing has an openable transparent observation window. The optical detection system includes a laser light source module, a spectral collection component, and a detector. The sample processing system includes a sample stage, auxiliary devices, and a transparent detection tube.

In one embodiment, an apparatus includes a needle that includes a substantially cylindrical shaft and a lumen, which includes a hollow space located within the shaft. The shaft includes a tip located at an end of the shaft, where the tip includes an opening. The apparatus also includes an optical fiber that includes an end face. The end face and at least a portion of the optical fiber are located within the lumen. The optical fiber is configured to transmit a pump-Stokes beam of light along the optical fiber toward the tip of the needle and to the end face, where the pump-Stokes beam is emitted from the end face and directed to a sample. The apparatus further includes a catheter that includes a catheter connector and a catheter tube having a substantially cylindrical shape, where the catheter tube surrounds at least a portion of the needle shaft.

The application belongs to the technical field of analysis and detection, and discloses a chiral detection platform based on a hydrogel SERS chip and application thereof.The core of the application is that the inherent chiral structure of a hydrogel matrix in a specific hydrogel SERS chip is found and utilized for the first time, so that specific enantiomers of chiral molecules can be directly and highly selectively recognized and detected without any exogenous chiral modifier or complex separation process.When the chip is used for detection with levomeprazole as a model analyte, only levomeprazole can be selectively adsorbed and produce a strong characteristic SERS signal, and the response of the dextrogyratory enantiomer is weak under the optimal conditions of an acid medium with pH 4.The sensor constructed by the method exhibits high sensitivity to levomeprazole, and the detection limit reaches 1.0x10 ‑7 mol / L, excellent selectivity and good anti-biological matrix interference capability, thereby providing a novel, simple and efficient solution for rapid analysis of chiral drugs.

The application relates to a surface enhanced Raman detection technology, in particular to a spherical composite SERS substrate and a preparation method and application thereof. The method comprises the following steps: adopting a micro flow injection pump to drop a solution containing silver nanowires and gold nanorods into liquid nitrogen, and then performing freeze drying; wherein, a gun head of the micro flow injection pump is a hydrophobic gun head; the concentration of the silver nanowires in the solution containing the silver nanowires and the gold nanorods is 15-40 mg / mL. The spherical composite SERS substrate prepared by the method has a spherical structure formed by silver nanowires and metal nanorods, the spherical skeleton structure is formed by interweaving silver nanowires into a net, and the metal nanorods are loaded on the silver nanowires, and the spherical composite SERS substrate can realize detection of rhodamine 6G without introducing a modifier.

The present application belongs to the technical field of chemical analysis, and particularly relates to a composite SERS substrate capable of repeated water washing and a preparation method and application thereof. The present application takes a flexible carbon cloth as a carrier, in-situ grows ZIF-8 on the surface of the flexible carbon cloth, and loads gold nanoparticles on the surface of the ZIF-8 to form a hierarchical composite structure. The present application solves the problems of easy peeling and easy instability of MOF on a flexible substrate from the aspects of a preparation method and a structure, so that the substrate can still maintain good structural integrity and flexible adaptability under the conditions of bending, washing and liquid immersion. Meanwhile, under the premise of not damaging the pore structure of MOF and the enhancement performance of noble metal, the present application introduces a hydrophobic interface to improve the water phase stability and washability, so as to effectively improve the anti-interference ability and detection reliability of the composite SERS substrate in complex liquid samples.

This invention relates to the field of mineral deposit exploration technology, specifically disclosing a method for determining the extension of magmatic hydrothermal deposits using fluid inclusions. The method involves collecting mineral samples containing fluid inclusions from the target deposit and its surrounding area using a systematic grid. Physicochemical parameters are obtained through petrography, microthermometry, and isotope analysis, and a spatial database is established. Multiple initial hydrothermal centers are identified. A multi-dimensional spatial constraint field is constructed, incorporating temperature-salinity-isotope gradients, mineralization depth, and magma-water mixing ratio. Using the initial centers as seed points, a neighborhood search is performed along the gradient synthesis direction. Sub-hydrothermal centers are generated and continuously grow when preset conditions are met, until an overlap threshold is reached, at which point iteration stops. All hydrothermal centers and growth paths are integrated to construct a spatial extension model. High-potential areas are screened using a target area evaluation index, and the extension direction and potential mineralization target areas are determined by combining the mineralization depth. This significantly improves the accuracy of concealed ore body prediction and the efficiency of mineral exploration.

The present application relates to a time-resolved spectrum measurement method and apparatus based on a multi-event time-to-digital converter, a device, and a medium. The method comprises: a multi-event time-to-digital converter performs histogram statistics on photon signals, which are responded at different times and correspond to each column of single-photon avalanche diodes, in different laser pulse periods, so as to determine photon signal distributions of a photon signal of a specific wavelength corresponding to each column of single-photon avalanche diodes in the different laser pulse periods; and the multi-event time-to-digital converter performs delayed merging on the photon signal distributions in the different laser pulse periods to determine a photon lifetime curve corresponding to the photon signal of a specific wavelength corresponding to each column of single-photon avalanche diodes, and integrates the photon lifetime curve corresponding to the photon signal of a specific wavelength corresponding to each column of single-photon avalanche diodes to construct a time-resolved spectrum of a sample to be measured. The present application can reduce the count loss or time error caused by dead time.

The application discloses a kind of Raman determination methods of boric acid and berberine hydrochloride in compound zinc sulfate eye drops, belong to the technical field of drug quality detection, the method determines the total boron content of sample using ion chromatography, determines the borax content of sample using potentiometric titration, boracic acid chemical reference value is obtained according to formula, and the chemical reference value of berberine hydrochloride is determined using high performance liquid chromatography method;Collect series sample Raman spectrum and carry out pretreatment;Using partial least square method, the quantitative model of boric acid and berberine hydrochloride is established respectively;The Raman spectrum of sample to be measured is substituted into the model, and the content of boric acid and berberine hydrochloride is output simultaneously.Compared with the current legal standard determination method, the application overcomes the problem of component interference determination in compound system, has higher specificity and accuracy, realizes the rapid, non-destructive, synchronous detection of two main components, and can be used for online monitoring in production process and daily supervision of drug supervision department.

In one embodiment, an apparatus includes a needle that includes a substantially cylindrical shaft and a lumen. The lumen includes a hollow space located within the shaft, and the shaft includes a tip located at an end of the shaft. The apparatus also includes an optical fiber that includes an end face, where the end face and at least a portion of the optical fiber are located within the lumen. The optical fiber is configured to transmit a pump-Stokes beam of light along the optical fiber toward the tip of the needle and to the end face, where the pump-Stokes beam is emitted from the end face and directed to a sample located in the lumen. The pump-Stokes beam is configured to produce a Raman signal by coherent Raman scattering of the pump-Stokes beam while propagating through the sample.

An optical device called NMS (nano-engineered microsphere) is developed, which consists of an optical microsphere with a built in nanoelement. By illuminating the microsphere, a photonic nanojet is created that illuminates the nanoelement at the tip of which plasmons are excited. The nanoelement can be, for example, a metal nanocone whose base is built in a microsphere, and plasmons are excited at the tip, or a nanowire with a metal tip. The microsphere can contain a cavity that offers additional protection for the nanoelement and can cause higher enhancement. When used, for example, in Raman spectroscopy, which we call NMERS (nano-engineered microsphere enhanced Raman spectroscopy), the joint action of the photonic nanojet and plasmon leads to a combined enhancement of Raman scattering, and if the sample is mapped, the resolution of the mapping is also improved. NMERS offers some improvements over the best enhancement methods so far such as SERS and TERS, and NMS can be used in a variety of other microscopic and spectroscopic applications.

A method for analyzing a mixture includes obtaining a first spectrum of the mixture comprising a plurality of components; selecting at least one position on the spectrum; and estimating a mixing weight for each of the components using an algorithm based on an intensity of the at least one position. A system for analyzing a mixture includes a spectrometer configured to obtain a first spectrum of the mixture comprising a plurality of components; a processor configured to select at least one position on the spectrum and estimate a mixing weight for each of the components using an algorithm based on an intensity of the at least one position.

According to an aspect there is provided an apparatus for Raman light detection, said apparatus comprising: an illumination unit, configured to provide a wavelength modulation for generating and outputting wavelength modulated laser light towards a sample for inducing generation of Raman scattered light from the sample; a wavelength filter for filtering the Raman scattered light; and a light detector, configured to receive the Raman scattered light filtered by the wavelength filter and to provide an instantaneous response signal dependent on an intensity of the received Raman scattered light.

The application discloses an in-situ optical-Raman-mass spectrum combined characterization system and method, and belongs to the technical field of in-situ characterization. The system mainly comprises a gas inlet unit, an in-situ electrochemical reaction cell (in-situ cell) and a gas outlet unit. In the in-situ cell device, from top to bottom, there are an optical window, an electrode one, a diaphragm rich in electrolyte, an electrode two and a gas inlet and outlet pipeline. According to different test purposes, the positions of the working electrode and the counter electrode (reference electrode) can be flexibly exchanged, and the working electrode can be close to the optical window or away from the optical window. The device is in a closed environment, can be tested under atmosphere control conditions, and can collect and analyze products in time. The application can realize in-situ optical microscope imaging, Raman and mass spectrum characterization, can simultaneously capture electrochemical signals-optical microscope imaging signals, electrochemical signals-Raman signals and electrochemical signals-mass spectrum signals, and has potential application value in the fields of energy and catalysis.

This invention belongs to the field of spectrometer control technology and discloses a cloud-edge hierarchical collaborative spectrometer safety self-regulation system and method, comprising: an edge real-time control module, configured as a micro-execution layer, communicating with the spectrometer's hardware driver interface, for receiving macro-strategy packets containing the working range sent by a large model agent, and performing high-frequency pulse closed-loop control on the spectrometer within the working range; a large model agent, asynchronously communicating with the edge real-time control module, configured as a macro-decision layer, for receiving experimental targets and generating macro-strategy packets; and a safety sandbox interceptor, serially set on the communication link between the large model agent and the edge real-time control module, for performing boundary checks on the macro-strategy packets based on safety thresholds, and intercepting the macro-strategy packets when the check fails. The safety thresholds include the sample's safety threshold and the physical safety boundary. This enables extremely rapid response and safety protection for spectrometer control.

A cartridge and a system for detecting viruses are described. The cartridge includes a cover, a base, a substrate configured to detect a virus, a sealing element, and a padding element. The cover has a top surface, an inner bottom surface, and a well having a hydrophobic wall extending from the top to the bottom surface. The well has a larger bore size at the top surface than a bore size at the bottom surface. The base is sealingly coupled to the cover to form an inner compartment. The sealing element is disposed within the inner compartment against the inner surface of the cover around the well. The padding element is disposed within the inner compartment on an inner surface of the base to support the substrate so that a sample of bodily fluid can form a pool within the well and stay in contact with the substrate.

The utility model discloses a portable detection device of regenerated polyester fiber, including detector main part, and detector main part is installed the probe interface, and the probe interface includes two sleeve joint parts of symmetrical settings, and one sleeve joint part inserts the detector main part, and the sleeve joint part of another sleeve joint part stretches out the detector main part, and the sleeve joint part is used for installing the probe, and the probe is connected with the sleeve joint part threadedly, the utility model provides a portable detection device of regenerated polyester fiber, reduces the replacement of accessory, improves the life.

The application discloses a kind of background noise suppression systems of dual optical comb coherent raman spectrum of probe light delay control, by setting the laser that light frequency comb light source module is emitted into probe light and pump light by first beam splitter in probe light delay control module, and setting optical delay line is applied to the probe light with delay amount, utilize the characteristics that the decay time of coherent raman spectrum signal is longer than the decay time of background noise, probe using probe light with delay amount, realize the purpose of inhibiting background noise, it is beneficial to improve the signal-to-noise ratio of dual optical comb coherent raman spectrum measurement system, inhibits spectrum signal distortion.