146 results about "Chemical groups" patented technology

[Problem] To provide: metal oxide particles that can be highly concentrated in an organic solvent, which is a dispersion medium for a metal oxide sol, and can also be redispersed in the organic solvent; a metal oxide sol containing the metal oxide particles; and a method for producing same. [Solution] Metal oxide particles surface-coated with a hydrolysate of a silane compound (A) having two chemical groups (a1) and two hydrolyzable groups (a2), wherein the metal oxide particles contain a basic compound (I) (excluding ammonia), have a hydrophobicity of 30-80 vol% as measured by a methanol titration method, and can be dispersed at a particle refractive index of 1.4-3.0 and at a metal oxide concentration of at least 40 mass% in an organic solvent, or can be dispersed at a particle refractive index of at least 1.1 and less than 1.4 and at a metal oxide concentration of at least 25 mass% in an organic solvent.

The present invention relates to a compound of formula (I) A-L1-RCG1 (I) wherein A is of formula (A), R1 is H, an optionally substituted alkyl, alkenyl, alkynyl, R2 is halogen, alkyl; alkenyl; alkynyl; alkylthio; alkylthioalkyl; alkyl-S(O)-; alkyl-S(O2)-; alkyl-S(O)-alkyl-; alkyl-S(O2)-alkyl-; alkoxy; alkoxyalkyl; haloalkoxyalkyl; cycloalkyl-O-alkyl; alkyl-NH- alkyl; (alkyl)2-N-alkyl; alkyl-NH; and (alkyl)2N; R3 is deuterium; H, alkyl; alkenyl; alkynyl; alkylthio; -OR6, -NR7R8, heterocycloalkyl, heteroaryl, aryl, cycloalkyl; L1 is a linker, RCG1 is a reactive chemical group. The present invention also relates to a compound of formula A- L1-G-BA (II) wherein G is the product of reaction between RCG1 and a reactive group RCG2 and BA is a binding agent, a pharmaceutical composition comprising it and its therapeutic uses, for instance for treating cancer.

The invention discloses a CRISPR (clustered regularly interspaced short palindromic repeats)-based homogeneous chemiluminescence kit as well as a preparation method and a use method thereof, and belongs to the technical field of nucleic acid detection. The kit comprises a Cas enzyme, crRNA, a chemiluminescence reporter molecule, a free radical scavenger and hydrogen peroxide. The chemiluminescent reporter molecule comprises a reporter molecule modified with a chemical group for coupling, one end of the reporter molecule is connected with a peroxidase-like catalytic activity center for reacting with peroxide to generate active free radicals, and the other end of the reporter molecule is connected with a luminescent substrate for reacting with the active free radicals to generate luminescence. According to the kit, a multifunctional microplate reader can be used for collecting chemiluminescence signals for quantifying the concentration of target nucleic acid. The kit is simple in operation steps and short in detection time, does not need light source excitation, and avoids self-luminous interference of a biological sample matrix, so that the kit has more excellent sensitivity and detection dynamic range.

A patch to be placed over an injury or defect in tissue in a biological structure having a lumen and preventing migration of contents of the biological structure through the injury or the defect. The patch includes an adhesive layer configured to adhere to the biological tissue via formation of hydrogen or covalent bonds with chemical groups present in the biological tissue and a backing layer coupled to and coextensive with the adhesive layer, the backing layer configured to be impervious to the contents.

The invention discloses a multicolor fluorescence emission lignin-based carbon dot as well as a preparation method and application thereof. The preparation method of the multicolor fluorescence emission lignin-based carbon dots comprises the following steps: (1) adding lignin and organic acid into water, and carrying out microwave treatment to obtain carbon dots A; (2) adding the carbon dots A and an oxidizing agent into water for oxidation reaction to obtain carbon dots B; (3) adding the B carbon dots into water, and then adding an alcohol compound and an acid catalyst for esterification reaction to obtain C carbon dots; (4) adding the C carbon dots and a reducing agent into water according to a ratio, and carrying out a reduction reaction to obtain D carbon dots; and (5) adding the D carbon dots and a basic catalyst into water, and carrying out a basic hydrolysis reaction to obtain the multicolor fluorescence emission lignin-based carbon dots. According to the invention, microwave digestion treatment is cooperated with a surface chemical group regulation method, and the prepared lignin-based carbon dots can realize blue, green, yellow and red fluorescence emission.

The invention provides a halogenated polysulfide aromatic hydrocarbon compound as well as a preparation method and application thereof. The structural formula of the halogenated polysulfide aromatic hydrocarbon compound is as shown in formula (I). Wherein X is one of F, Cl and Br. The halogenated polysulfide aromatic hydrocarbon compound disclosed by the invention can be used as a photoluminescent material and is a photostimulation response type luminescent material. The molecular structural formula of the photoluminescent material is as shown in a formula (1), and in the molecular structural formula of the photoluminescent material, based on a hexasulfobenzene unit as a core skeleton, the material is endowed with a unique photostimulation response characteristic through specific chemical group modification. The innovative material not only shows excellent light response capability, but also has the characteristic of aggregation-induced emission enhancement, so that the material has potential application value in the fields of biological imaging technology, organic light-emitting material application and the like.

The present invention discloses novel molecules consisting of N-methyl-D-aspartate receptor (NMDAR) antagonists-polymer conjugates having a general structure D-(X-Poly-T)n, wherein D is an high affinity, i.e., (+)-, (−)-, or (±)-dizocilpine, or a low affinity, i.e., (+)-, (−)-, or (±)-methadone, CNS active NMDAR antagonist, n is an integer comprised between 1 and 6. X is a stable (enzymatically and / or hydrolytically under physiological conditions) linker comprising a covalent bond or a chain of atoms that covalently attaches a small molecule NMDAR antagonist drug moiety to the Poly derivative. Poly is a covalently bonded chain of repeating monomer units that form a polymer or an oligomer backbone of synthetic or natural origin. T, if present, is either another molecule of D, or a terminal group of Poly, represented by any suitable chemical group which, depending upon preference, is unreactive or reactive with other chemical moieties, or has a targeting property.

To provide metal oxide particles that are capable of being highly concentrated in an organic solvent acting as a dispersion medium of a metal oxide sol, and also capable of being redispersed in the organic solvent, as well as a metal oxide sol containing the metal oxide particles and methods for producing them.SOLUTION: The present invention provides metal oxide particles that are surface-coated with a hydrolysate of a silane compound (A) having two chemical groups (a1) and two hydrolyzable groups (a2), and a hydrolysate of a silane compound (B) having three chemical groups (b1) and one hydrolyzable group (b2), wherein the metal oxide particles contain a basic compound (I), and the metal oxide particles have a particle refractive index of 1.4 to 3.0 and are dispersible in an organic solvent at 40 mass% or more in terms of metal oxide concentration, or have a particle refractive index of 1.1 to less than 1.4 and are dispersible in an organic solvent at 25 mass% or more in terms of metal oxide concentration.SELECTED DRAWING: Figure 1

The invention belongs to the technical field of biology, and relates to a composition for enhancing and distinguishing miRNA and pre-miRNA and a one-step detection method, the composition for enhancing and distinguishing miRNA and pre-miRNA comprises forward and reverse primers, a Linker sequence, a block sequence, a fluorescent probe and a reaction mixed solution; the reverse primer is also used as a reverse transcription primer of the miRNA; the 3'end of the Linker sequence is modified and blocked by a chemical group and cannot extend, and the modified group of the Linker sequence comprises one or more of a phosphate group, C3, C6 and C9. The invention designs a miRNA one-step method RT-qPCR detection technology for the competitive reaction of the block and the Linker sequence, so that the differentiated detection of enhanced miRNA and pre-miRNA is realized.

The invention provides a sealing material for wet tissues as well as a preparation method and application of the sealing material. The sealing material comprises a hydrophobic oil phase and temperature-sensitive microspheres, the temperature-sensitive microspheres are dispersed in the hydrophobic oil phase to form a heterogeneous system; the temperature-sensitive microsphere is of a core-shell structure, and the core-shell structure comprises an inner core and an outer shell wrapping the inner core; the inner core comprises a temperature-sensitive cross-linked network and polysaccharide capable of being subjected to ionic cross-linking, and the shell is a porous shell body network and is formed by carrying out copolymerization reaction on a natural polymer derivative capable of being subjected to photo-crosslinking and a comonomer containing an active chemical group. The temperature-sensitive microspheres with core-shell structures are designed to cooperate with the hydrophobic oil phase, rapid hemostasis of dynamic and bleeding wet tissues is realized through a dual drainage mechanism of instantaneous drainage of the hydrophobic oil phase and active pumping of the temperature-sensitive inner core, and then stable chemical bonding is formed through cross-linking of the shell and tissue protein, so that the rapid hemostasis of the dynamic and bleeding wet tissues is realized. And the wet tissue is sealed.

The present invention relates to the technical field of polyimide film surface modifiers, and more particularly to a polyimide film surface modifier and its preparation method and application. The polyimide film surface modifier is measured in concentration and includes: amines 9.0-10.0 g / L; quaternized polyvinyl imidazole 0.7-0.8 g / L; inorganic salt 0.2-0.4 g / L; alkylphenol polyoxyethylene ether 0.25-0.35 g / L; reducing agent 1.8-2.5 mL / L; inorganic base 0.8-1.0 g / L; alcohol amines 2.5-3.5 mL / L; the rest is deionized water. After the polyimide film surface modifier is metallized to the PI film surface, full coverage is obtained in a relatively short time, so that the PI film surface produces more chemical groups of phenolic groups and amines, plasma physical modification treatment can be exempted, and there is no need to use a PI adjuster, and the function of a pore-forming agent is combined, thereby reducing the cost of metallization treatment of the polyimide film surface.

The present invention discloses novel molecules consisting of N-methyl-D-aspartate receptor (NMDAR) antagonist-polymer conjugates having the general structure D-(X-Poly-T) n wherein D is a high affinity, i.e. (+)-, (-)-or (+-)-dezocycline, or a low affinity, i.e. (+)-, (-)-or (+-)-methadone, CNS active NMDAR antagonist, n is an integer from 1 to 6. X is a stable (enzymatic and / or hydrolytic under physiological conditions) linker comprising a covalent bond or atomic chain covalently linking a small molecule NMDAR antagonist drug moiety to the Poly derivative. Poly is a covalently bonded chain of repeating monomer units forming a polymer backbone of synthetic or natural origin. T, if present, is another molecule of D, or an end group of Poly, represented by any suitable chemical group which, according to preference, does not react with or with other chemical moieties, or has targeting properties.

The invention discloses 1-MHMD as well as a preparation method and application thereof. Relates to the technical field of biological medicine. According to the invention, 1-methylhydantoin and metformin are spliced into a novel compound with medical application on the basis of a medicine splicing principle; the compound 1-MHMD can be prepared by determining the reaction sequence of chemical groups at two ends of R1 in XR1COR2 and metformin hydrochloride or 1-methylhydantoin through a preparation method of an intermediate I and a preparation method of an intermediate II, and multiple choices are provided for future production; the compound 1-MHMD is few in by-product, easy to purify and high in purity; the preparation method is simple, convenient, few in steps and low in energy consumption; the 1-methylhydantoin and the metformin are combined for the first time, the effects of combining the medicine effects and reducing toxic and side effects can be achieved, the molecular weight is smaller than or equal to 500, and the compound has great development value in the fields of medicine and health care products for reducing blood sugar and blood fat, losing weight, treating fatty liver and the like.

The invention discloses a kit and a device for detecting acinetobacter baumannii. The kit comprises a first primer, a second primer, recombinase polymerase, Cas12a protein, crRNA and ssDNA, wherein the sequence of the first primer is as shown in SEQ ID NO.1; the sequence of the second primer is as shown in SEQ ID NO. 2; the sequence of the crRNA is as shown in SEQ ID NO.3, the crRNA is modified with a light-sensitive chemical group for preventing the combination of the crRNA and target nucleic acid, and the light-sensitive chemical group falls off from the crRNA when irradiated by light with a predetermined wavelength; the sequence of the ssDNA is as shown in SEQ ID NO.4, one end of the ssDNA is modified with a fluorophore, and the other end of the ssDNA is modified with a quenching group. By adopting the kit or the device provided by the invention, the acinetobacter baumannii can be accurately detected, the working efficiency can be improved, and the risk of cross contamination can be reduced.

The invention discloses a membrane desalination pretreatment process of an immersed UF. The membrane desalination pretreatment process of the immersed UF comprises the following steps: S1, feeding system incoming water into a homogeneous regulation tank; s2, the effluent of the homogeneous regulation tank enters a high-density tank 1 #, and a chemical group 1 is put into the high-density tank 1 # to remove hardness of the tank water. According to the membrane desalination pretreatment process of the immersed UF, provided by the invention, the membrane desalination pretreatment process of the high-density clarification tank and the immersed UF is adopted, so that high-salinity wastewater can be pretreated, normal and stable operation of a subsequent membrane system and the quality and stability of evaporative crystallization of saltpeter are ensured, and the multiple immersed UF membrane tanks which are designed in parallel are used, so that the operation efficiency is improved. Compared with sand filtration, carbon filtration and pressure type ultrafiltration devices, the immersed UF membrane pool has the advantages of less maintenance points, low investment, low operation cost, reduction of the investment and operation cost, pollution blockage resistance and high suspended matter impact resistance.

According to one embodiment, a catalyst system that reduces polymeric fouling may comprise at least one titanate compound, at least one aluminum compound, and at least one antifouling agent or a derivative thereof. The antifouling agent may comprise a structure comprising a central aluminum molecule bound to an R1 group, bound to an R2 group, and bound to an R3 group. One or more of the chemical groups R1, R2, and R3 may be antifouling groups comprising the structure —O((CH2)nO)mR4, where n is an integer from 1 to 20, m is an integer from 1 to 100, and R4 is a hydrocarbyl group. The chemical groups R1, R2, or R3 that do not comprise the antifouling group, if any, may be hydrocarbyl groups.

Methods for preparing of uniform spherical magnetic beads between 50 nm to 5 microns. This involves the formation of a uniform emulsion of hydrophobically coated nanoparticles dispensed in volatile organic solvent in an aqueous solution contains thickening agent and surfactant. Control of the chemical and physical parameters of emulsification enables adjustment of bead size. Methods for coating a silica layer on the spherical magnetic beads including: 1) a continuous silicate layer around the iron oxide core; and 2) a porous silica layer that has a defined pore size between 1 and 200 nm and thickness between 1 and 10,000 nm. The silica layer can be functionalized with chemical groups, including amine or carboxyl, or coated with a range of biochemical compounds, including peptides, proteins, or DNA, to facilitate separation and / or reaction. Kits for performing size selective separation and / or reaction including the extraction of specific size nucleic acids, proteins and macromolecules.

A tough, corrosion-resistant, non-equimolar #imgabs0# high-entropy nitride ceramic coating and a preparation method thereof, wherein the chemical composition of the high-entropy nitride ceramic coating is #imgabs1# (where #imgabs2#), and the element ratio (x i and y), so that the valence electron concentration (VEC) of the coating system is close to the optimal value, thereby obtaining a high-entropy nitride coating with optimal mechanical and chemical properties. The non-equimolar #imgabs3# high-entropy nitride ceramic material provided by the present invention is a single-phase face-centered cubic structure, with a hardness greater than 28GPa and a fracture toughness H 3 / E 2 The high entropy nitride ceramic coating provided by the present invention can meet the performance requirements of applications in the fields of nuclear power facilities, processing tools, aerospace equipment or medical equipment.

An example of a method includes providing a substrate with an exposed surface comprising a first chemical group, wherein the providing optionally comprises modifying the exposed surface of the substrate to incorporate the first chemical group; reacting the first chemical group with a first reactive group of a functionalized polymer molecule to form a functionalized polymer coating layer covalently bound to the exposed surface of the substrate; grafting a primer to the functionalized polymer coating layer by reacting the primer with a second reactive group of the functionalized polymer coating layer; and forming a water-soluble protective coating on the primer and the functionalized polymer coating layer. Examples of flow cells incorporating examples of the water-soluble protective coating are also disclosed herein.

The invention belongs to the technical field of fuel cells, and particularly relates to a gas diffusion layer structure with durability and high conductivity and a preparation method and application thereof. The prepared gas diffusion layer comprises a metal ion capture layer, a substrate layer and a microporous layer which are sequentially stacked, the metal ion capture layer contains a metal ion capture material, and the metal ion capture material is selected from one or more of polyethyleneimine, polyacrylic acid, polyvinyl alcohol, chitosan and a perfluorosulfonic acid ionomer; specifically, a metal ion capture layer is constructed on a substrate layer close to one side of a flow channel, the conductivity of the gas diffusion layer is improved by using a method of strong interaction force between a high electronegativity chemical group and metal ions, and meanwhile, the metal ions are efficiently captured in a broad-spectrum manner, so that the gas diffusion layer has a wide application prospect.

To provide a base preferable for covalently bonding at least one biologically active molecule to a carrier molecule.SOLUTION: Provided is a base which consists of a) polymer or oligomer structure, and b) at least one saponin SO1861 covalently bonded to the polymer or an oligomer structure, the base further contains c) a first chemical group for coupling the base to a carrier molecule in a covalently bonded state, e) the base is preferable for covalently bonding the at least one saponin SO1861 to the carrier molecule, and f) the carrier molecule contains or consists of any one of protein molecule, protein, peptide, nucleic acid, oligonucleotide, lipid, fat, fatty acid, nanoparticle and carbohydrate.SELECTED DRAWING: None

A patch to be placed over an injury or defect in tissue in a biological structure having a lumen and preventing migration of contents of the biological structure through the injury or the defect. The patch includes an adhesive layer configured to adhere to the biological tissue via formation of hydrogen or covalent bonds with chemical groups present in the biological tissue and a backing layer coupled to and coextensive with the adhesive layer, the backing layer configured to be impervious to the contents.

The present invention relates to compounds of formula (I) below and methods of synthesizing compounds of formula (I) below. [Formula 1] JPEG2025500462000059.jpg7347 (in the formula: - T is -CHO, -CH=NOH, and -CN + -O - represents a chemical group selected from the group consisting of: - R1 represents a chemical group selected from the group consisting of -OCH3, -OCH2CH3, and -OR3; - R2 represents a chemical group selected from the group consisting of -OCH3 and -OR3; - with the proviso that R1 or R2 is -OR3; R3 represents a chemical group of formula (II) [chemical 2] JPEG2025500462000060.jpg3670 (· where E represents a divalent C1-C12 hydrocarbon group which may contain one or more heteroatoms; X1, X2, and X3 may be the same or different and represent a hydrogen atom, a C1-C6 alkyl, or a C6-C14 aryl; The symbol * represents the point of attachment of the group of formula (II) to the oxygen atom)

Nucleic acid enzymes such as DNAzymes are provided, including nucleic acid enzymes that can be used for detection or quantification of a cofactor, such as a metal ion, in a cell. Methods for concurrent detection of mRNA from cells are also provided and can benefit from modifications to the nucleic acid enzyme such as, e.g., inclusion of a polyadenine (poly-A) tail and / or nonnative chemical groups. The methods may utilize SNAIL probes for spatial transcriptomics, combining SNAIL probes with DNAzymes for spatial metallomics, e.g., to image metal ions spatially.

The instant invention concerns a process for fragmenting a polymer chain, comprising an oxidative degradation step wherein the polymer chain is contacted with a reduced form of a metal M and an oxidant such as dioxygen, and wherein the polymer carries covalently bound chemical groups acting as a ligand of said reduced form of the metal M.The invention also relates to methods making use of this fragmentation process as a first step of a degradation process of the polymer especially useful for avoiding the negative impact of a polymer to the environment. In this connection, the invention relates to the use of polymers carrying chemical groups acting as a ligand for a reduced form of a metal M, as a polymer biodegradable in an environment wherein the reduced form of a metal M is present.

The present invention belongs to the field of organic polymers, and particularly relates to an amphiphilic triblock polymer, a stimulus-responsive nanoparticle and a preparation method thereof. The amphiphilic triblock polymer provided by the present invention has a chemical structure shown in formula (I), formula (II) or formula (III). The phenylborate / borate structure in the amphiphilic triblock polymer can generate hydroxide ions under the trigger of hydrogen peroxide, and the hydroxide ions will accelerate the trigger of phenylborate / borate by hydrogen peroxide, thus forming a positive feedback loop to continuously accelerate the rapid degradation of the polymer backbone. In addition, the polymer terminal can be modified with chemical groups or polypeptides to endow the polymer with more functions. The amphiphilic triblock polymer provided by the present invention has good application prospects in the fields of drug delivery and tumor treatment.

The invention relates to a hemoglobin oxygen carrier based on small molecule modification as well as a preparation method and application thereof. The hemoglobin oxygen carrier comprises hemoglobin and N-fluoromethoxycarbonyl diphenylalanine, the hemoglobin forms the hemoglobin oxygen-carrying carrier through the non-covalent bond acting force between the hemoglobin and the N-fluoromethoxycarbonyl diphenylalanine. According to the hemoglobin oxygen carrier disclosed by the invention, a co-assembly strategy of N-fluoromethoxycarbonyl diphenylalanine and hemoglobin is rapidly implemented by taking a non-covalent bond acting force as a driving force. The hemoglobin oxygen-carrying carrier prepared by the process greatly shortens the stabilization time of hemoglobin molecules on the basis of ensuring the stability of molecular chemical groups, has good biocompatibility and injectable application characteristics on the basis of the characteristics of non-covalent acting force, and provides a new foundation for research and development of a new generation of hemoglobin oxygen-carrying carriers. And an engineering design thought and a theoretical basis are provided.

To provide a new specific SPECT radiopharmaceutical with high sensitivity for the detection of FAP protein expression in the tumour microenvironment, which is based on boronPro-type inhibitors (molecular-target radiopharmaceuticals).SOLUTION: Provided is a new fibroblast activation protein (iFAP) inhibitory radiopharmaceutical based on ((R)-1-((6-hydrazinylnicotinoyl)-D-alanyl)pyrrolidin-2-yl)boronic acid (HYNIC-iFAP), wherein ethylenediamine diacetic acid is used to complete the coordination sphere of the radiometal, combining the conventional use of HYNIC as a chelating agent for the radiometal 99mTc, and wherein the nitrogens of the hydrazine of HYNIC act as chemical groups that promote the interaction of the HYNIC-iFAP molecule with phenylalanine, glutamic acid, and serine in the active centre of fibroblast activation protein (FAP).SELECTED DRAWING: None

The invention discloses an ultrathin electromagnetic shielding layer based on a magnetron sputtering technology and a preparation method thereof, and the method comprises the steps: carrying out the oxygen plasma etching of the surface of a flexible substrate through a reactive ion etching technology, the reactive ion etching power ranges from 100 W to 140 W, so that an activated substrate surface chemical group is formed on the surface of the flexible substrate; a seed layer is formed on the etched surface of the flexible substrate in a sputtering mode through the magnetron sputtering technology, the thickness of the seed layer ranges from 1 nm to 100 nm, and the roughness of the seed layer is 10 nm or below; forming a layer of shielding metal film on the surface of the seed layer through sputtering by using a magnetron sputtering technology, wherein the thickness of the shielding metal film is less than 1 [mu] m; wherein the sputtering temperature in the magnetron sputtering process ranges from 100 DEG C to 150 DEG C.