48 results about "Chemical groups" patented technology

The invention provides a sealing material for wet tissues as well as a preparation method and application of the sealing material. The sealing material comprises a hydrophobic oil phase and temperature-sensitive microspheres, the temperature-sensitive microspheres are dispersed in the hydrophobic oil phase to form a heterogeneous system; the temperature-sensitive microsphere is of a core-shell structure, and the core-shell structure comprises an inner core and an outer shell wrapping the inner core; the inner core comprises a temperature-sensitive cross-linked network and polysaccharide capable of being subjected to ionic cross-linking, and the shell is a porous shell body network and is formed by carrying out copolymerization reaction on a natural polymer derivative capable of being subjected to photo-crosslinking and a comonomer containing an active chemical group. The temperature-sensitive microspheres with core-shell structures are designed to cooperate with the hydrophobic oil phase, rapid hemostasis of dynamic and bleeding wet tissues is realized through a dual drainage mechanism of instantaneous drainage of the hydrophobic oil phase and active pumping of the temperature-sensitive inner core, and then stable chemical bonding is formed through cross-linking of the shell and tissue protein, so that the rapid hemostasis of the dynamic and bleeding wet tissues is realized. And the wet tissue is sealed.

An example of a method includes providing a substrate with an exposed surface comprising a first chemical group, wherein the providing optionally comprises modifying the exposed surface of the substrate to incorporate the first chemical group; reacting the first chemical group with a first reactive group of a functionalized polymer molecule to form a functionalized polymer coating layer covalently bound to the exposed surface of the substrate; grafting a primer to the functionalized polymer coating layer by reacting the primer with a second reactive group of the functionalized polymer coating layer; and forming a water-soluble protective coating on the primer and the functionalized polymer coating layer. Examples of flow cells incorporating examples of the water-soluble protective coating are also disclosed herein.

The invention relates to a hemoglobin oxygen carrier based on small molecule modification as well as a preparation method and application thereof. The hemoglobin oxygen carrier comprises hemoglobin and N-fluoromethoxycarbonyl diphenylalanine, the hemoglobin forms the hemoglobin oxygen-carrying carrier through the non-covalent bond acting force between the hemoglobin and the N-fluoromethoxycarbonyl diphenylalanine. According to the hemoglobin oxygen carrier disclosed by the invention, a co-assembly strategy of N-fluoromethoxycarbonyl diphenylalanine and hemoglobin is rapidly implemented by taking a non-covalent bond acting force as a driving force. The hemoglobin oxygen-carrying carrier prepared by the process greatly shortens the stabilization time of hemoglobin molecules on the basis of ensuring the stability of molecular chemical groups, has good biocompatibility and injectable application characteristics on the basis of the characteristics of non-covalent acting force, and provides a new foundation for research and development of a new generation of hemoglobin oxygen-carrying carriers. And an engineering design thought and a theoretical basis are provided.

The application discloses a blood glucose detection electrode, a nucleic acid detection electrode and a preparation method. The vertical graphene is grown by a PECVD method and has a three-dimensional petal-like structure. The vertical graphene under the structure is more solid than planar graphene. The vertical graphene can be used for grafting of chemical groups such as carboxyl groups, amino groups, aldehyde groups and hydroxyl groups in a plasma mode. The groups are introduced by the method, the structure and the conductivity of the vertical graphene are not damaged, the nucleic acid and the antibody are more favorable to occupy active sites, more nucleic acid and antibody are loaded, the electrochemical detection signal is improved, and in addition, the step of sealing can be omitted, and interference is avoided. The method can realize industrial production.

The application relates to the technical field of organic synthesis, and discloses an acyl silicon reagent as well as a preparation method and application thereof. The acyl silicon reagent provided by the application has reducible chemical groups such as halogen and ester groups, can react with various amine compounds to generate amide compounds, has a wide application substrate range and high selectivity; the synthesis method of the amide compound can efficiently and highly selectively synthesize polypeptides, polymers and other amide compounds under the condition of anhydrous organic solvents or organic solvent aqueous solutions, and the yield of the amide compound is high.

The application belongs to the technical field of organic optoelectronic material preparation and application, and discloses a boron-nitrogen heterocyclic derivative based on a fusion donor, preparation and application thereof.The organic material takes a boron-nitrogen heterocyclic ring containing different numbers of ring-forming boron atoms as a core, and is obtained by extending the molecular skeleton through the conjugation and ring of the peripheral chemical groups of the fusion donor.The boron-nitrogen heterocyclic derivative based on the fusion donor has excellent light and thermal stability, good electrochemical stability, and excellent electroluminescent performance, and can be applied to an organic electroluminescent device as a host material or a sensitizing agent material or a luminescent material, so that higher device efficiency, stability and color purity can be obtained.

This invention provides a method for protein functionalization involving post-translational modification in a manner that is selective, reliable, and under the possibility of benign, moderate redox, enabling the addition of reactive functional side chains. [Solution] The present invention relates to photoredox-mediated functionalization of proteins at chemical groups via radical generation and CC bond formation using specific boronate and sulfone precursor compounds. The present invention also relates to functionalized proteins that can be produced by this method, and the specific boronate and sulfone precursor compounds themselves.

A method for coating a substrate comprising at least one chemical group is provided by contacting the substrate surface with a compound comprising at least one carbon-carbon double bond or a mixture of a first monomer M1 and a second monomer M2. Then, a reaction is initiated by the reaction of the photoactive group and the carbon-carbon double bond by subjecting at least a portion of the formed complex to actinic radiation, wherein the wavelength of the actinic radiation is suitable for being absorbed by the photoactive group, to form a covalent bond. The method is largely resistant to inhibition by impurities in the substrate surface. Greater uniformity of the elastic modulus of the entire substrate and the added layer can be achieved. When an additional topcoat is applied, the resulting surface has high hardness, and the scratch resistance is improved. When a top sheet is applied, the abrasion resistance is improved.

The invention discloses a silicon nanowire water photovoltaic device, a preparation method and a water photovoltaic cell. The silicon nanowire water photovoltaic device comprises an n-type silicon nanowire layer, a top electrode arranged on the top surface of the n-type silicon nanowire layer and a bottom electrode arranged on the bottom surface of the n-type silicon nanowire layer, wherein Si-OH groups on the surface of the n-type silicon nanowire layer are at least partially substituted by chemical bonds or chemical groups with the electron withdrawing capability weaker than that of the Si-OH groups. According to the silicon nanowire water photovoltaic device, the preparation method and the water photovoltaic cell provided by the invention, Si-OH groups on the surfaces of the silicon nanowires are at least partially replaced by chemical bonds or chemical groups with relatively weak electron attraction capability, so that the number of free electrons in the silicon nanowires can be remarkably increased through the replacement; and when microcirculation caused by water evaporation enables a charge carrier in the silicon nanowire to move directionally, more electrons can participate in the process, so that the hydrovolt effect is enhanced, and the electrical property of the silicon nanowire hydrovolt device is remarkably improved.

The application provides a sealing material for wet tissues, a preparation method and application thereof, and the sealing material comprises a hydrophobic oil phase and temperature-sensitive microspheres; the temperature-sensitive microspheres are dispersed in the hydrophobic oil phase to form a heterogeneous system; the temperature-sensitive microspheres have a core-shell structure, the core-shell structure comprises a core and a shell covering the core; the core comprises a temperature-sensitive cross-linked network and an ion-cross-linkable polysaccharide, and the shell is a porous shell body network and is formed by a copolymerization reaction of a light-cross-linkable natural polymer derivative and a co-monomer containing an active chemical group. The application realizes rapid hemostasis on dynamic and bleeding wet tissues through a double drainage mechanism of the hydrophobic oil phase instantaneously draining liquid and the temperature-sensitive core actively pumping, and realizes sealing on the wet tissues through the shell and tissue protein cross-linking to form stable chemical adhesion.

This invention provides methods for producing a polymer particle which contains unusually high negative charges on the surface of the particle. Preferably, the polymer is pharmaceutically acceptable. The negative charges can be conferred by chemical groups such as carboxyl, sulfonate, nitrate, fluorate, chloride, iodide, persulfate, and many others, with carboxyl group being preferred. The invention also provides polymer particle produced by the methods of the invention.

The present invention relates to the field of producing protein conjugates. The invention relates to a novel method for producing a protein conjugate comprising a protein of interest (POI) bearing a chemical moiety and a payload comprising a complementary chemical moiety. The said method comprises the extracellular expression of the POI, contacting the POI in the cell culture supernatant with the payload, allowing the formation of a covalent bond between the POI and the payload in a cell culture supernatant, thereby creating a protein conjugate, and purifying said conjugate.

The invention relates to a preparation method and application of sugar-responsive protamine insulin, which comprises the following steps: modifying a chemical group on cysteine of protamine, connecting with a phenylboronic acid compound to form a compound, and mixing with insulin to prepare the sugar-responsive protamine insulin. The sugar-responsive insulin preparation can realize an intelligent sugar-responsive regulation mechanism. Specifically, the insulin can be slowly released at a normal blood glucose level and is accelerated to be released at a hyperglycemia state, so that the blood glucose is effectively regulated and controlled, and the occurrence of hypoglycemia is avoided.

The application provides a kind of explosive performance simulation design method based on energy, safety and process, comprising: step one, the simulation model between the chemical composition of explosive formula and detonation velocity is established, that is, the energy performance simulation model of explosive formula;Step two, the simulation model between the sensitizing chemical group contained in explosive formula and impact sensitivity is established, that is, the safety performance simulation model of explosive formula;Step three, the simulation model between the average particle size of raw material in explosive formula and dynamic viscosity is established, that is, the process performance simulation model of explosive formula;Step four, on the basis of step one, step two and step three, the comprehensive performance characterization parameter is taken as the comprehensive processing result of explosive detonation velocity, explosive impact sensitivity and explosive dynamic viscosity, and the comprehensive performance simulation model of explosive formula is established.The simulation model construction method involved in the application has clear and distinct levels, the comprehensive performance characterization parameter is formed by linear weighting of detonation velocity, impact sensitivity and dynamic viscosity, so that the comprehensive performance of a group of explosive formulas with different component contents is analyzed and compared, and has a wide range of application.

The present disclosure relates to calixpyrrole compounds and compositions thereof. The calixpyrrole compounds are chemical groups which are located in such a manner so as to be useful for the selective extraction of specific salts. Also provided herein are compositions and methods of use thereof.

This invention relates to a method for preparing glucose-responsive protamine insulin and its application. The method involves modifying chemical groups on the cysteine ​​residues of protamine and linking them with phenylboronic acid compounds to form a complex, which is then mixed with insulin to prepare glucose-responsive protamine insulin. This glucose-responsive insulin formulation achieves an intelligent glucose response regulation mechanism. Specifically, under normal blood glucose levels, the insulin is released slowly, while under hyperglycemic conditions, its release is accelerated, thereby achieving effective blood glucose control and preventing hypoglycemia.

The invention discloses a battery monomer, a battery device and a power utilization device. Each battery monomer comprises a positive pole piece and a negative pole piece which are oppositely arranged, a diaphragm is also arranged between the positive pole piece and the negative pole piece, the diaphragm comprises a diaphragm base material and a material coating laminated with at least one surface of the diaphragm base material, the material coating comprises a porous material and an additive, and the additive contains at least one chemical group. The chemical group comprises at least one of a silicon-oxygen bond, an amino group and an isocyanate group. In the diaphragm material coating of the battery monomer, the porous material has a water absorption effect, the additive can adsorb hydrogen ions or perform a chemical reaction with the hydrogen ions, and through the combined action of the porous material and the additive, the side effects of acid and water in the battery can be reduced by utilizing the diaphragm, so that the cycle life of the battery is prolonged.

Organoiodine compounds are provided that contain a radiopaque moiety, such as iodine, and an additional chemical group that increases solubilization, mixing, and / or compatibilization with various materials with which the compounds are mixed.SOLUTION: The present invention relates to an iodine compound comprising at least one 2,4,6 - triiodobenzene moiety, wherein at least one of the hydrogens in position 1, 3 and 5 of the 2,4,6 - triiodobenzene moiety is substituted by an iodinated substituent comprising one or more iodophenyl-containing groups. It also relates to compositions containing such iodine compounds and methods of making such iodine compounds.SELECTED DRAWING: Figure 1A

The application relates to the technical field of OLED display, in particular to a quantum dot printing OLED device, which specifically comprises an anode substrate layer, a hole transport layer, a functional film layer, a hole blocking layer and a metal cathode layer; during production, the OLED is prepared by combining photolithography, inkjet printing and vacuum evaporation; in addition, inorganic salt halides are introduced into the quantum dots, so that the chemical groups of the quantum dots react with the inorganic salt halides to be passivated, and the functional film layer with the protection function is formed; the method can reduce the influence of surface tension on the film formation of the quantum dots, improve the uniformity of the film formation in the pixel of the printing OLED device, and further improve the performance of the printing OLED device.

The invention discloses an identification method and application of a traditional Chinese medicine composition taste quality marker, and belongs to the technical field of traditional Chinese medicine taste evaluation. The identification method comprises the following steps: S1, establishing a sensory prediction model: collecting electronic tongue data and human body sensory evaluation data of a traditional Chinese medicine composition sample, and establishing a correction model according to the electronic tongue data and the human body sensory evaluation data; s2, collecting chemical group data and sensory group data: identifying chemical components of the traditional Chinese medicine composition by adopting a UPLC-Q-Exactive / MS (Ultra Performance Liquid Chromatography-Quantitative Exactive / Mass Spectrometry) analysis method to obtain semi-quantitative data of the chemical components; and S3, screening and verifying the key sensory markers: performing multivariate statistical modeling, locking a key marker group, and performing molecular docking verification. According to the method, a high-resolution mass spectrometry analysis technology, an electronic tongue and a human body sensory score are combined, chemical data and sensory data are deeply correlated by utilizing a multivariate statistical method, and candidate markers with high variable importance are screened out.

The application relates to a phosphate-based sponge fertilizer, a preparation method thereof and application, and belongs to the technical field of agricultural fertilizers. In order to solve the technical problems of low phosphorus availability, uncontrollable porous structure, single function and non-green process of the existing phosphate-based sponge fertilizer, the application provides the phosphate-based sponge fertilizer and the preparation method thereof. The preparation method of the phosphate-based sponge fertilizer takes a polymer (polyacrylamide) formed by grafting acrylamide on a starch skeleton as a carrier, and the surface of the carrier is modified by adding chemical groups, the hydrophobicity of the carrier is enhanced, the reaction with a polar soil solution is reduced, and the slow-release control ability for phosphorus is retained; the surface charge and functional groups of the carrier are regulated by loading a phosphorus activator (such as a biochar-based functional group and rock wool), the fixation of soil ions on phosphorus is inhibited, and the fertilizer availability is improved. The phosphate-based sponge fertilizer prepared by the application has high phosphorus availability, controllable porous structure, good synergism of water retention and fertilizer release functions, and can be used for promoting crop growth.

The present application relates to the technical field of chemical synthesis, in particular to an antibacterial dental resin material based on natural molecule cholic acid. The present application takes cholic acid as raw material, first sequentially gives cholic acid through esterification reaction and acylation reaction photo-curable chemical groups, and then sequentially gives cholic acid through activation reaction and substitution reaction high antibacterial groups to obtain photo-curable high antibacterial cholic acid derivative monomer. The photo-curable high antibacterial cholic acid derivative monomer can be used for the preparation of dental resin material, realizes the improvement of the biocompatibility and antibacterial performance of the dental resin material, has small cytotoxicity, in addition, can avoid the problems such as antibacterial agent leakage and poor antibacterial effect in traditional dental resin material, and has wide application prospect.

The present invention belongs to the technical field of cellulose. Disclosed are a modified fiber fabric and a preparation method therefor, which solve the technical problem in the prior art of sodium and potassium remaining on a water-absorbing material in CMC-H modified fiber products and thus affecting the biocompatibility of the water-absorbing material. In the modified fiber fabric and the preparation method therefor provided by the present invention, the fiber fabric raw material sequentially modified into carboxymethyl cellulose and subjected to an ammoniation treatment with ammonia gas on the basis of maintaining a fibrous shape, so as to obtain the fiber fabric with ammonium carboxymethyl cellulose as the modified material; the fiber fabric raw material is subjected to a modification treatment reaction on the basis of maintaining the fibrous shape, specifically, during the modification treatment reaction, in fiber molecules of the fiber fabric raw material, 1,4-glucosidic bonds in glucose molecules are linked to form parallel cellulose chains without changing, and specific chemical groups occupying specific carbon positions C6, C2 and C3 on the molecular chains of fibers are subjected to a modification reaction, thereby ensuring the softness and physical properties of the product paper or non-woven fabric.

The present invention relates to the technical field of organic synthesis. Disclosed are an acyl silicon reagent, and a preparation method therefor and the use thereof. The acyl silicon reagent provided in the present invention has reducible chemical groups, such as a halogen and an ester group, can react with a variety of amine compounds to form amide compounds, and is applicable to a wide range of substrates and has high selectivity. A synthesis method for an amide compound comprises efficiently and highly selectively synthesizing an amide compound, such as a polypeptide and a polymer, in an anhydrous organic solvent or an aqueous solution of an organic solvent from the acyl silicon reagent and an amine compound, and the yield of the amide compound is high.

The present application relates to the technical field of antitumor drugs, and particularly relates to a kind of PROTACs compound targeted to degrade BCL6 and application thereof, and the compound is the compound shown in formula (I) or its stereoisomer, geometric isomer, tautomer, nitroxide, solvate, pharmaceutically acceptable salt, metabolite or prodrug.The PROTACs compound targeted to degrade BCL6 provided in the present application connects BCL6 protein ligand and E3 ubiquitin ligase ligand through chemical groups;The compound can be used to inhibit the proliferation, growth, migration, infiltration, clonal formation and metastasis of tumor cells, promote the apoptosis of cancer cells, promote the autophagy of tumor cells, overcome the drug resistance of chemotherapy or targeted therapy of tumor, inhibit the growth of tumor stem cells, and prolong the survival period of tumor patients.

The present invention concerns the field of modified nucleic acids, and in particular aptamer, ribozyme or deoxyribozyme functional nucleic acids, and methods for selecting (SELEX) such modified nucleic acids. The invention concerns nucleobases, nucleosides and nucleotides modified by a particular chemical group, and the uses thereof, in particular in methods for reverse transcription, amplification and selection of functional nucleic acids, regardless of the chemical group attached to the modified nucleic acids to be selected, provided that said group is cleavable via an SPICC reaction.

The invention discloses injectable hemostatic hydrogel based on engineering modified cell derivatives as well as a preparation method and application of the injectable hemostatic hydrogel, and belongs to the technical field of biomedical materials. Chemical bonding and photo-crosslinking are cooperated, a membrane anchoring component is used for modifying the surface of a cell derivative to introduce an active chemical group, the active chemical group reacts with a hydrogel matrix complementary functional group to form a covalent bond, and a photoinitiator drives hydrogel to be crosslinked and cured under illumination, so that the cell derivative is stably fixed, burst release is avoided, and the biological function exerting efficiency is improved. The preparation method comprises the steps of engineering modification, stirring reaction, illumination crosslinking and the like, so that long-term stable loading of the cell derivative is realized. The hydrogel is high in biological safety and excellent in effect on substantive organ hemorrhage, and a new thought and scheme are provided for targeted delivery and controllable immobilization in the field of cell derivative-based biological materials.

The application discloses a method for reducing thermal contact resistance of thermal interface material, comprising: (1) grafting silane coupling agent containing active group I on the surface of a device; (2) coating thermal interface matrix containing active group II on the surface of the device obtained in step (1); (3) reacting the active group II and the active group I; wherein the reaction is at least one selected from the group consisting of thiol-alkenyl click reaction, amidation reaction of amino and carboxyl, condensation reaction of amino and aldehyde group, and addition reaction of hydroxyl and isocyanate. The application reduces the thermal contact resistance by the reaction between the silane coupling agent and the active group of the thermal interface matrix. The method provided by the application does not need additional modification process of the thermal interface material, and only relies on the inherent chemical groups to realize the chemical bond connection between the device surface and the thermal interface material, and the method is simple and effective.

A method for manufacturing metal oxide particles that can be concentrated at a high concentration and redispersed in an organic solvent as a dispersion medium for metal oxide sols is provided. The metal oxide particles have a surface coated with a hydrolysate of a silane compound (A) having two chemical groups (a1) and two hydrolyzable groups (a2). The metal oxide particles contain a basic compound (I) (excluding ammonia) and have a hydrophobicity of 30-80% by volume as determined by methanol titration. When the refractive index of the metal oxide particles is 1.4-3.0, the metal oxide particles can be dispersed in an organic solvent at a metal oxide concentration of 40% by mass or more; or when the refractive index of the metal oxide particles is 1.1 or more and less than 1.4, the metal oxide particles can be dispersed in an organic solvent at a metal oxide concentration of 25% by mass or more.