116 results about "Chemical groups" patented technology

[Problem] To provide: metal oxide particles that can be highly concentrated in an organic solvent, which is a dispersion medium for a metal oxide sol, and can also be redispersed in the organic solvent; a metal oxide sol containing the metal oxide particles; and a method for producing same. [Solution] Metal oxide particles surface-coated with a hydrolysate of a silane compound (A) having two chemical groups (a1) and two hydrolyzable groups (a2), wherein the metal oxide particles contain a basic compound (I) (excluding ammonia), have a hydrophobicity of 30-80 vol% as measured by a methanol titration method, and can be dispersed at a particle refractive index of 1.4-3.0 and at a metal oxide concentration of at least 40 mass% in an organic solvent, or can be dispersed at a particle refractive index of at least 1.1 and less than 1.4 and at a metal oxide concentration of at least 25 mass% in an organic solvent.

The invention discloses a CRISPR (clustered regularly interspaced short palindromic repeats)-based homogeneous chemiluminescence kit as well as a preparation method and a use method thereof, and belongs to the technical field of nucleic acid detection. The kit comprises a Cas enzyme, crRNA, a chemiluminescence reporter molecule, a free radical scavenger and hydrogen peroxide. The chemiluminescent reporter molecule comprises a reporter molecule modified with a chemical group for coupling, one end of the reporter molecule is connected with a peroxidase-like catalytic activity center for reacting with peroxide to generate active free radicals, and the other end of the reporter molecule is connected with a luminescent substrate for reacting with the active free radicals to generate luminescence. According to the kit, a multifunctional microplate reader can be used for collecting chemiluminescence signals for quantifying the concentration of target nucleic acid. The kit is simple in operation steps and short in detection time, does not need light source excitation, and avoids self-luminous interference of a biological sample matrix, so that the kit has more excellent sensitivity and detection dynamic range.

A patch to be placed over an injury or defect in tissue in a biological structure having a lumen and preventing migration of contents of the biological structure through the injury or the defect. The patch includes an adhesive layer configured to adhere to the biological tissue via formation of hydrogen or covalent bonds with chemical groups present in the biological tissue and a backing layer coupled to and coextensive with the adhesive layer, the backing layer configured to be impervious to the contents.

The invention provides a halogenated polysulfide aromatic hydrocarbon compound as well as a preparation method and application thereof. The structural formula of the halogenated polysulfide aromatic hydrocarbon compound is as shown in formula (I). Wherein X is one of F, Cl and Br. The halogenated polysulfide aromatic hydrocarbon compound disclosed by the invention can be used as a photoluminescent material and is a photostimulation response type luminescent material. The molecular structural formula of the photoluminescent material is as shown in a formula (1), and in the molecular structural formula of the photoluminescent material, based on a hexasulfobenzene unit as a core skeleton, the material is endowed with a unique photostimulation response characteristic through specific chemical group modification. The innovative material not only shows excellent light response capability, but also has the characteristic of aggregation-induced emission enhancement, so that the material has potential application value in the fields of biological imaging technology, organic light-emitting material application and the like.

The present invention discloses novel molecules consisting of N-methyl-D-aspartate receptor (NMDAR) antagonists-polymer conjugates having a general structure D-(X-Poly-T)n, wherein D is an high affinity, i.e., (+)-, (−)-, or (±)-dizocilpine, or a low affinity, i.e., (+)-, (−)-, or (±)-methadone, CNS active NMDAR antagonist, n is an integer comprised between 1 and 6. X is a stable (enzymatically and / or hydrolytically under physiological conditions) linker comprising a covalent bond or a chain of atoms that covalently attaches a small molecule NMDAR antagonist drug moiety to the Poly derivative. Poly is a covalently bonded chain of repeating monomer units that form a polymer or an oligomer backbone of synthetic or natural origin. T, if present, is either another molecule of D, or a terminal group of Poly, represented by any suitable chemical group which, depending upon preference, is unreactive or reactive with other chemical moieties, or has a targeting property.

To provide metal oxide particles that are capable of being highly concentrated in an organic solvent acting as a dispersion medium of a metal oxide sol, and also capable of being redispersed in the organic solvent, as well as a metal oxide sol containing the metal oxide particles and methods for producing them.SOLUTION: The present invention provides metal oxide particles that are surface-coated with a hydrolysate of a silane compound (A) having two chemical groups (a1) and two hydrolyzable groups (a2), and a hydrolysate of a silane compound (B) having three chemical groups (b1) and one hydrolyzable group (b2), wherein the metal oxide particles contain a basic compound (I), and the metal oxide particles have a particle refractive index of 1.4 to 3.0 and are dispersible in an organic solvent at 40 mass% or more in terms of metal oxide concentration, or have a particle refractive index of 1.1 to less than 1.4 and are dispersible in an organic solvent at 25 mass% or more in terms of metal oxide concentration.SELECTED DRAWING: Figure 1

The invention belongs to the technical field of biology, and relates to a composition for enhancing and distinguishing miRNA and pre-miRNA and a one-step detection method, the composition for enhancing and distinguishing miRNA and pre-miRNA comprises forward and reverse primers, a Linker sequence, a block sequence, a fluorescent probe and a reaction mixed solution; the reverse primer is also used as a reverse transcription primer of the miRNA; the 3'end of the Linker sequence is modified and blocked by a chemical group and cannot extend, and the modified group of the Linker sequence comprises one or more of a phosphate group, C3, C6 and C9. The invention designs a miRNA one-step method RT-qPCR detection technology for the competitive reaction of the block and the Linker sequence, so that the differentiated detection of enhanced miRNA and pre-miRNA is realized.

The invention provides a sealing material for wet tissues as well as a preparation method and application of the sealing material. The sealing material comprises a hydrophobic oil phase and temperature-sensitive microspheres, the temperature-sensitive microspheres are dispersed in the hydrophobic oil phase to form a heterogeneous system; the temperature-sensitive microsphere is of a core-shell structure, and the core-shell structure comprises an inner core and an outer shell wrapping the inner core; the inner core comprises a temperature-sensitive cross-linked network and polysaccharide capable of being subjected to ionic cross-linking, and the shell is a porous shell body network and is formed by carrying out copolymerization reaction on a natural polymer derivative capable of being subjected to photo-crosslinking and a comonomer containing an active chemical group. The temperature-sensitive microspheres with core-shell structures are designed to cooperate with the hydrophobic oil phase, rapid hemostasis of dynamic and bleeding wet tissues is realized through a dual drainage mechanism of instantaneous drainage of the hydrophobic oil phase and active pumping of the temperature-sensitive inner core, and then stable chemical bonding is formed through cross-linking of the shell and tissue protein, so that the rapid hemostasis of the dynamic and bleeding wet tissues is realized. And the wet tissue is sealed.

The present invention relates to the technical field of polyimide film surface modifiers, and more particularly to a polyimide film surface modifier and its preparation method and application. The polyimide film surface modifier is measured in concentration and includes: amines 9.0-10.0 g / L; quaternized polyvinyl imidazole 0.7-0.8 g / L; inorganic salt 0.2-0.4 g / L; alkylphenol polyoxyethylene ether 0.25-0.35 g / L; reducing agent 1.8-2.5 mL / L; inorganic base 0.8-1.0 g / L; alcohol amines 2.5-3.5 mL / L; the rest is deionized water. After the polyimide film surface modifier is metallized to the PI film surface, full coverage is obtained in a relatively short time, so that the PI film surface produces more chemical groups of phenolic groups and amines, plasma physical modification treatment can be exempted, and there is no need to use a PI adjuster, and the function of a pore-forming agent is combined, thereby reducing the cost of metallization treatment of the polyimide film surface.

The invention discloses a kit and a device for detecting acinetobacter baumannii. The kit comprises a first primer, a second primer, recombinase polymerase, Cas12a protein, crRNA and ssDNA, wherein the sequence of the first primer is as shown in SEQ ID NO.1; the sequence of the second primer is as shown in SEQ ID NO. 2; the sequence of the crRNA is as shown in SEQ ID NO.3, the crRNA is modified with a light-sensitive chemical group for preventing the combination of the crRNA and target nucleic acid, and the light-sensitive chemical group falls off from the crRNA when irradiated by light with a predetermined wavelength; the sequence of the ssDNA is as shown in SEQ ID NO.4, one end of the ssDNA is modified with a fluorophore, and the other end of the ssDNA is modified with a quenching group. By adopting the kit or the device provided by the invention, the acinetobacter baumannii can be accurately detected, the working efficiency can be improved, and the risk of cross contamination can be reduced.

According to one embodiment, a catalyst system that reduces polymeric fouling may comprise at least one titanate compound, at least one aluminum compound, and at least one antifouling agent or a derivative thereof. The antifouling agent may comprise a structure comprising a central aluminum molecule bound to an R1 group, bound to an R2 group, and bound to an R3 group. One or more of the chemical groups R1, R2, and R3 may be antifouling groups comprising the structure —O((CH2)nO)mR4, where n is an integer from 1 to 20, m is an integer from 1 to 100, and R4 is a hydrocarbyl group. The chemical groups R1, R2, or R3 that do not comprise the antifouling group, if any, may be hydrocarbyl groups.

Methods for preparing of uniform spherical magnetic beads between 50 nm to 5 microns. This involves the formation of a uniform emulsion of hydrophobically coated nanoparticles dispensed in volatile organic solvent in an aqueous solution contains thickening agent and surfactant. Control of the chemical and physical parameters of emulsification enables adjustment of bead size. Methods for coating a silica layer on the spherical magnetic beads including: 1) a continuous silicate layer around the iron oxide core; and 2) a porous silica layer that has a defined pore size between 1 and 200 nm and thickness between 1 and 10,000 nm. The silica layer can be functionalized with chemical groups, including amine or carboxyl, or coated with a range of biochemical compounds, including peptides, proteins, or DNA, to facilitate separation and / or reaction. Kits for performing size selective separation and / or reaction including the extraction of specific size nucleic acids, proteins and macromolecules.

An example of a method includes providing a substrate with an exposed surface comprising a first chemical group, wherein the providing optionally comprises modifying the exposed surface of the substrate to incorporate the first chemical group; reacting the first chemical group with a first reactive group of a functionalized polymer molecule to form a functionalized polymer coating layer covalently bound to the exposed surface of the substrate; grafting a primer to the functionalized polymer coating layer by reacting the primer with a second reactive group of the functionalized polymer coating layer; and forming a water-soluble protective coating on the primer and the functionalized polymer coating layer. Examples of flow cells incorporating examples of the water-soluble protective coating are also disclosed herein.

The invention belongs to the technical field of fuel cells, and particularly relates to a gas diffusion layer structure with durability and high conductivity and a preparation method and application thereof. The prepared gas diffusion layer comprises a metal ion capture layer, a substrate layer and a microporous layer which are sequentially stacked, the metal ion capture layer contains a metal ion capture material, and the metal ion capture material is selected from one or more of polyethyleneimine, polyacrylic acid, polyvinyl alcohol, chitosan and a perfluorosulfonic acid ionomer; specifically, a metal ion capture layer is constructed on a substrate layer close to one side of a flow channel, the conductivity of the gas diffusion layer is improved by using a method of strong interaction force between a high electronegativity chemical group and metal ions, and meanwhile, the metal ions are efficiently captured in a broad-spectrum manner, so that the gas diffusion layer has a wide application prospect.

To provide a base preferable for covalently bonding at least one biologically active molecule to a carrier molecule.SOLUTION: Provided is a base which consists of a) polymer or oligomer structure, and b) at least one saponin SO1861 covalently bonded to the polymer or an oligomer structure, the base further contains c) a first chemical group for coupling the base to a carrier molecule in a covalently bonded state, e) the base is preferable for covalently bonding the at least one saponin SO1861 to the carrier molecule, and f) the carrier molecule contains or consists of any one of protein molecule, protein, peptide, nucleic acid, oligonucleotide, lipid, fat, fatty acid, nanoparticle and carbohydrate.SELECTED DRAWING: None

A patch to be placed over an injury or defect in tissue in a biological structure having a lumen and preventing migration of contents of the biological structure through the injury or the defect. The patch includes an adhesive layer configured to adhere to the biological tissue via formation of hydrogen or covalent bonds with chemical groups present in the biological tissue and a backing layer coupled to and coextensive with the adhesive layer, the backing layer configured to be impervious to the contents.

Nucleic acid enzymes such as DNAzymes are provided, including nucleic acid enzymes that can be used for detection or quantification of a cofactor, such as a metal ion, in a cell. Methods for concurrent detection of mRNA from cells are also provided and can benefit from modifications to the nucleic acid enzyme such as, e.g., inclusion of a polyadenine (poly-A) tail and / or nonnative chemical groups. The methods may utilize SNAIL probes for spatial transcriptomics, combining SNAIL probes with DNAzymes for spatial metallomics, e.g., to image metal ions spatially.

The instant invention concerns a process for fragmenting a polymer chain, comprising an oxidative degradation step wherein the polymer chain is contacted with a reduced form of a metal M and an oxidant such as dioxygen, and wherein the polymer carries covalently bound chemical groups acting as a ligand of said reduced form of the metal M.The invention also relates to methods making use of this fragmentation process as a first step of a degradation process of the polymer especially useful for avoiding the negative impact of a polymer to the environment. In this connection, the invention relates to the use of polymers carrying chemical groups acting as a ligand for a reduced form of a metal M, as a polymer biodegradable in an environment wherein the reduced form of a metal M is present.

The present invention belongs to the field of organic polymers, and particularly relates to an amphiphilic triblock polymer, a stimulus-responsive nanoparticle and a preparation method thereof. The amphiphilic triblock polymer provided by the present invention has a chemical structure shown in formula (I), formula (II) or formula (III). The phenylborate / borate structure in the amphiphilic triblock polymer can generate hydroxide ions under the trigger of hydrogen peroxide, and the hydroxide ions will accelerate the trigger of phenylborate / borate by hydrogen peroxide, thus forming a positive feedback loop to continuously accelerate the rapid degradation of the polymer backbone. In addition, the polymer terminal can be modified with chemical groups or polypeptides to endow the polymer with more functions. The amphiphilic triblock polymer provided by the present invention has good application prospects in the fields of drug delivery and tumor treatment.

The invention relates to a hemoglobin oxygen carrier based on small molecule modification as well as a preparation method and application thereof. The hemoglobin oxygen carrier comprises hemoglobin and N-fluoromethoxycarbonyl diphenylalanine, the hemoglobin forms the hemoglobin oxygen-carrying carrier through the non-covalent bond acting force between the hemoglobin and the N-fluoromethoxycarbonyl diphenylalanine. According to the hemoglobin oxygen carrier disclosed by the invention, a co-assembly strategy of N-fluoromethoxycarbonyl diphenylalanine and hemoglobin is rapidly implemented by taking a non-covalent bond acting force as a driving force. The hemoglobin oxygen-carrying carrier prepared by the process greatly shortens the stabilization time of hemoglobin molecules on the basis of ensuring the stability of molecular chemical groups, has good biocompatibility and injectable application characteristics on the basis of the characteristics of non-covalent acting force, and provides a new foundation for research and development of a new generation of hemoglobin oxygen-carrying carriers. And an engineering design thought and a theoretical basis are provided.

To provide a new specific SPECT radiopharmaceutical with high sensitivity for the detection of FAP protein expression in the tumour microenvironment, which is based on boronPro-type inhibitors (molecular-target radiopharmaceuticals).SOLUTION: Provided is a new fibroblast activation protein (iFAP) inhibitory radiopharmaceutical based on ((R)-1-((6-hydrazinylnicotinoyl)-D-alanyl)pyrrolidin-2-yl)boronic acid (HYNIC-iFAP), wherein ethylenediamine diacetic acid is used to complete the coordination sphere of the radiometal, combining the conventional use of HYNIC as a chelating agent for the radiometal 99mTc, and wherein the nitrogens of the hydrazine of HYNIC act as chemical groups that promote the interaction of the HYNIC-iFAP molecule with phenylalanine, glutamic acid, and serine in the active centre of fibroblast activation protein (FAP).SELECTED DRAWING: None

The invention discloses an ultrathin electromagnetic shielding layer based on a magnetron sputtering technology and a preparation method thereof, and the method comprises the steps: carrying out the oxygen plasma etching of the surface of a flexible substrate through a reactive ion etching technology, the reactive ion etching power ranges from 100 W to 140 W, so that an activated substrate surface chemical group is formed on the surface of the flexible substrate; a seed layer is formed on the etched surface of the flexible substrate in a sputtering mode through the magnetron sputtering technology, the thickness of the seed layer ranges from 1 nm to 100 nm, and the roughness of the seed layer is 10 nm or below; forming a layer of shielding metal film on the surface of the seed layer through sputtering by using a magnetron sputtering technology, wherein the thickness of the shielding metal film is less than 1 [mu] m; wherein the sputtering temperature in the magnetron sputtering process ranges from 100 DEG C to 150 DEG C.

The invention relates to organic electroluminescent materials and devices. The present invention provides a compound having a first ligand LA comprising the structure of Formula I: # imgabs0 # in Formula I, at least one of the following is true: (1) RC comprises at least one silyl group or germanium alkyl group; or (2) RC is formula II # imgabs1 # with the proviso that Y2 and RB are not joined to form a ring; and if part D is phenyl; if at least one RD contains one chemical group selected from the group consisting of deuterium, halogen, alkyl having five or more carbon atoms, cycloalkyl, heteroalkyl, heterocycloalkyl, aralkyl, alkoxy, aryloxy, amino, silyl, germanyl, boryl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carboxylic acid, ether, ester, nitrile, isonitrile, sulfanyl, r1, R2, R3, R4, R5, R6, R7, R7, R7, R8, R8, R8, R8, R8, formulations, OLEDs, and consumer products containing the compounds are also provided.

The application discloses a blood glucose detection electrode, a nucleic acid detection electrode and a preparation method. The vertical graphene is grown by a PECVD method and has a three-dimensional petal-like structure. The vertical graphene under the structure is more solid than planar graphene. The vertical graphene can be used for grafting of chemical groups such as carboxyl groups, amino groups, aldehyde groups and hydroxyl groups in a plasma mode. The groups are introduced by the method, the structure and the conductivity of the vertical graphene are not damaged, the nucleic acid and the antibody are more favorable to occupy active sites, more nucleic acid and antibody are loaded, the electrochemical detection signal is improved, and in addition, the step of sealing can be omitted, and interference is avoided. The method can realize industrial production.

The present invention discloses a preparation method and application of a water repellent with self-recovering water repellency after washing, belonging to the field of environmentally friendly polymer technology. The present invention utilizes the unsaturated double bonds contained in the surface of modified titanium dioxide to undergo free radical polymerization with the acrylic ester monomers used in the synthesis of the water repellent, and the titanium dioxide and the main skeleton of the water repellent are connected by chemical groups, so that the titanium dioxide particles and the water repellent polymer are stably present in the water repellent emulsion, and the water repellent has high film fastness. The light-heat conversion ability of nano titanium dioxide and its contribution to the roughness of the fabric surface make the finished fabric have water repellency such as high static water contact angle, high hydrostatic pressure resistance, and high spray resistance. The fabric does not need to be dried after washing, and the spray resistance level can be effectively restored by conventional natural drying. At the same time, the ultraviolet shielding performance of nano titanium dioxide gives the fabric treated with the water repellent prepared by the present invention an anti-ultraviolet function.

The application relates to the technical field of organic synthesis, and discloses an acyl silicon reagent as well as a preparation method and application thereof. The acyl silicon reagent provided by the application has reducible chemical groups such as halogen and ester groups, can react with various amine compounds to generate amide compounds, has a wide application substrate range and high selectivity; the synthesis method of the amide compound can efficiently and highly selectively synthesize polypeptides, polymers and other amide compounds under the condition of anhydrous organic solvents or organic solvent aqueous solutions, and the yield of the amide compound is high.

The invention provides a compound, the general formula of which is A-L-B. In the general formula, A is a chemical group which specifically binds or activates STING (stimulating interferon gene) protein; b is a chemical group specifically combined with LC3 (microtubule-associated protein-1 light chain 3) protein; l is a chemical linker. The compound can effectively mediate the degradation of STING protein and is used for treating inflammatory diseases.

The application belongs to the technical field of organic optoelectronic material preparation and application, and discloses a boron-nitrogen heterocyclic derivative based on a fusion donor, preparation and application thereof.The organic material takes a boron-nitrogen heterocyclic ring containing different numbers of ring-forming boron atoms as a core, and is obtained by extending the molecular skeleton through the conjugation and ring of the peripheral chemical groups of the fusion donor.The boron-nitrogen heterocyclic derivative based on the fusion donor has excellent light and thermal stability, good electrochemical stability, and excellent electroluminescent performance, and can be applied to an organic electroluminescent device as a host material or a sensitizing agent material or a luminescent material, so that higher device efficiency, stability and color purity can be obtained.

This invention provides a method for protein functionalization involving post-translational modification in a manner that is selective, reliable, and under the possibility of benign, moderate redox, enabling the addition of reactive functional side chains. [Solution] The present invention relates to photoredox-mediated functionalization of proteins at chemical groups via radical generation and CC bond formation using specific boronate and sulfone precursor compounds. The present invention also relates to functionalized proteins that can be produced by this method, and the specific boronate and sulfone precursor compounds themselves.