2747 results about "Thiazole" patented technology

The invention relates to chemical compounds useful as inhibitors of class II phosphoinositide 3- kinase (PI3K) signalling. The invention further relates to the medical use of inhibitors of class II phosphoinositide 3-kinase (PI3K) signalling in the treatment of medical conditions associated with defective and / or pathologic class II phosphoinositide 3-kinase (PI3K) signaling, such as stroke, a cardiovascular disease related to endothelial cell dysfunction, cancer, cancer metastasis, myopathy and diabetes.

The invention relates to the field of medicinal chemistry, in particular to thiazolidinedione compounds containing quinoline structures and application of the thiazolidinedione compounds. The compound can influence the interaction between KRAS and downstream protein cRaf, namely indirectly inhibits the function of KRAS, and further inhibits the proliferation of tumor cells, and the compound and the pharmaceutical preparation thereof can be used for treating a series of diseases caused by KRAS dysfunction, mainly KRASG12D related cancers, such as KRASG12D related cancers, KRASG12D related cancers, KRASG12D related cancers, KRASG12D related cancers, KRASG12D related cancers, KRASG12D related cancers, for example, colon cancer, rectal cancer, pancreatic cancer, lung cancer, endometrial cancer, skin cancer and the like.

The present disclosure is directed to thiazolopyridin-7(4h)-one based compounds, including compounds of Formula (I) and pharmaceutically acceptable salts thereof, and compositions thereof, as well as methods of treatment of cancers such as those involving WRN protein.

The invention discloses a wear-resistant and high-temperature-resistant synchronous belt and a preparation method thereof. The wear-resistant and high-temperature-resistant synchronous belt comprises a synchronous belt framework and a synchronous belt rubber sheet, the synchronous belt rubber sheet is prepared from the following raw materials: a fluorosilicone thermoplastic polyurethane elastomer containing a benzene ring structure, an amino-containing hyperbranched liquid crystal polymer, methyl vinyl phenyl silicone rubber, epoxidized natural rubber, molybdenum sulfide nanosheets, reinforced fibers, bis (1-vinyl imidazole-2-) ketone, 2-acrylamido-2-methylpropanesulfonic acid, 4, 4 '-difluoro-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1 The high-temperature-resistant rubber is prepared from 2, 6-hydroxy-2-cyanobenzothiazole, bis (3-aminophenyl) 3, 5-bis (trifluoromethyl) phenylphosphine oxide, a catalyst, a coupling agent, a vulcanizing agent, an anti-aging agent, a scorch retarder and a lubricating agent. The synchronous belt is good in mechanical property, sufficient in high-temperature resistance and cold resistance, good in wear resistance and excellent in aging resistance and flame retardance.

The invention discloses a method for detecting glufosinate-ammonium residues in coffee in dual modes of colorimetry and chemiluminescence, and belongs to the technical field of chemical analysis and detection.The method comprises the steps that Schiff base formed by 4-aminoantipyrine and glutaraldehyde serves as a complexing agent of Cu < 2 + >, and then a copper-doped carbon dot Cu-CDs nano-enzyme is prepared through microwave digestion; according to the present invention, the Cu-CDs nano-enzyme has excellent peroxidase-like activity, can oxidize the colorless 2, 2 '-biazo-bis-3-ethylbenzothiazoline-6-sulfonic acid into the blue-green oxidized ABTS, and can improve the chemiluminescence intensity of the reaction of N-(4-aminobutyl)-N-ethylisoluminol and H2O2 by nearly 100 times when the Cu-CDs nano-enzyme is used as the chemiluminescence catalyst; based on the inhibition effect of glufosinate-ammonium on the activity of Cu-CDs POD, a sensitive and rapid colorimetric and chemiluminescence two-channel GM detection technology is developed, and the method has potential application value in the aspect of coffee safety monitoring.

The invention relates to the field of pesticide bactericides, and discloses a difluoromethyl thiazole amide-containing compound and application thereof as a bactericide. The difluoromethyl thiazole-containing amide compound has a structure as shown in a formula (I), and the difluoromethyl thiazole-containing amide compound with efficient activity on diseases such as rice sheath blight disease is designed by introducing a difluoromethyl thiazole-containing structure and a diphenyl ether fragment. The compound can be used as a brand new succinate dehydrogenase inhibitor or bactericide. # imgabs0 #

The application relates to a compound of formula (I) containing a thiazole ring, an indazol ring and a 6,7-dihydro-5H-pyrrolo[1,2-c]imidazole ring system, to pharmaceutical compositions containing it and its medical use. The compounds are described as selective allosteric inhibitors of T790M / L858R, T790M / L858R / C797S, L858R, L858R / C797S containing EGFR mutants and thus useful for the treatment of cancer, in particular non-small cell lung cancer.

The invention relates to the field of coatings, and discloses an outer wall light radiation heat preservation and heat insulation decorative sheet and a preparation method thereof.A radiation refrigeration layer on the surface of the outer wall light radiation heat preservation and heat insulation decorative sheet comprises modified acrylate resin, silicon dioxide, ground calcium carbonate, talcum powder, modified hollow glass beads and auxiliaries; the modified acrylate resin is prepared by copolymerizing perfluorooctyl ethyl acrylate, methyl methacrylate, modified isocyano ethyl methacrylate and vinyltriethoxysilane, and the modified isocyano ethyl methacrylate is prepared by using salicylaldehyde and benzothiazole-2-formaldehyde as well as 1, 2, 4-trimethyl-1, 3-pentanediol monoisobutyrate as an initiator and using 2, 3, 4-trimethyl-1, 3-pentanediol monoisobutyrate as an initiator. The preparation method comprises the following steps: reacting amino groups at two ends of 1, 5-naphthylenediamine with DOPO, carrying out nucleophilic addition reaction with DOPO, and grafting with isocyano ethyl methacrylate. The modified hollow glass beads are prepared by using tetrabutyl titanate as a titanium source through a sol-gel method, and the prepared radiation refrigeration layer has the super-amphiphobic self-cleaning effect, the radiation refrigeration effect is good, and meanwhile the flame retardant property and the antibacterial effect are excellent.

The invention discloses a thiazolinone acrylic acid silane ester self-polishing antifouling resin and a preparation method and application of the thiazolinone acrylic acid silane ester self-polishing antifouling resin. The preparation method of the thiazolinone acrylic acid silane ester self-polishing antifouling resin mainly comprises the following steps: in a nitrogen environment, adding an initiator, the preparation method comprises the following steps: carrying out random free radical polymerization reaction on thiazolinone methacrylate, methyl methacrylate, ethyl acrylate, triisopropyl silicon-based methacrylate and phenyl dimethyl silicon-based methacrylate by taking azodiisobutyronitrile and benzoyl peroxide as initiators to synthesize the photoinitiator. Wherein the thiazolinone methacrylate monomer is prepared by grafting double bonds on 5-chloro-2-benzothiazolinone and methacryloyl chloride through a substitution reaction, then grafting hydroxyl on the 5-chloro-2-benzothiazolinone and mercaptoethanol through a mercapto-alkene click reaction and finally carrying out a substitution reaction on the 5-chloro-2-benzothiazolinone and methacryloyl chloride. According to the invention, the coating still has good surface self-renewal capability even in a static environment so as to inhibit the adhesion of large fouling organisms.

The invention discloses a sunlight response high-strength self-repairing polyurethane material and a preparation method thereof, and belongs to the technical field of self-repairing materials, the sunlight response high-strength self-repairing polyurethane material is obtained by coordinating polyurethane containing an azothiazole structure and metal ions according to a certain proportion, the polyurethane containing the azothiazole structure is prepared by stirring diisocyanate, diol containing the azothiazole structure, long-chain diol and aminophenylboronic acid according to a certain proportion in N, N-dimethylformamide at room temperature to react for 5 hours. According to the invention, a photoactive azothiazole structure is introduced into polyurethane, and reversible metal coordination bonds are formed by the azothiazole structure and metal ions, so that rapid sunlight response self-repairing of the polyurethane material is realized. The self-repairing efficiency of the prepared photoresponse self-repairing polyurethane material is 95.1% after the photoresponse self-repairing polyurethane material is irradiated by sunlight for 2 h, and the photoresponse self-repairing polyurethane material has rapid photoresponse self-repairing performance and has wide application prospects in the fields of self-repairing coatings, intelligent coatings and anti-corrosion coatings.

The invention discloses a preparation method of a thiazole ring modified C3N4 / C3N5 heterojunction photocatalyst, which comprises the following steps: weighing a certain amount of C3N4 raw material, C3N5 raw material and thiazole raw material, adding into deionized water, fully stirring and dissolving, evaporating, drying, and grinding to obtain a mixture precursor; calcining the obtained mixture precursor at a certain temperature, cooling to room temperature, and grinding; the obtained sample is repeatedly washed with deionized water and absolute ethyl alcohol until supernate is colorless, then centrifugation, drying and grinding are conducted in sequence, and the obtained sample is the thiazole ring modified C3N4 / C3N5 heterojunction photocatalyst. The method is simple in preparation process, low in energy consumption and easy to industrialize, and the prepared thiazole ring modified C3N4 / C3N5 heterojunction photocatalyst is applied to production of H2O2 and can have high photocatalytic activity.

The invention discloses a preparation method of an FSP1 inhibitor FSEN3, which comprises the following steps: by taking 4-methoxybenzoyl hydrazine and allyl isothiocyanate as raw materials, forming a thiourea intermediate through nucleophilic addition reaction, carrying out cyclization reaction under the action of alkali, then reacting with liquid bromine to construct a thiazolotriazole skeleton, and finally preparing the FSP1 inhibitor FSEN3. And then carrying out substitution reaction with indoline to obtain a target product FSEN3 as shown in a formula (I). The total synthesis method provided by the invention is mild in condition, simple and convenient to operate and high in total yield. # imgabs0 #

A corrosion inhibitor composition includes a fatty acid ethoxylate, a thiourea, an arylthiourea, a thiazole, and two or more solvents. A metal article in contact with the composition has a corrosion rate of about 25 to about 45 mils penetration per year (mpy), as determined by an ASTM G111 standard test method. A method for inhibiting corrosion of a metal in contact with a corrosive fluid.

The invention relates to an application of a regulator in improving the maturation quality of frozen pig oocytes, the regulator is N-(2-(2-(4-chlorphenyl) thiazole-4-yl) ethyl) butyryl, and the regulator improves the maturation quality of the frozen pig oocytes by improving the mitochondrial function of the frozen pig oocytes after in-vitro maturation. The invention provides a new application of N-(2-(2-(4-chlorphenyl) thiazole-4-yl) ethyl) butyramide, namely the N-(2-(2-(4-chlorphenyl) thiazole-4-yl) ethyl) butyramide is used for developing a novel oocyte vitrification freezing solution and an in-vitro maturation culture solution, and the obtained high-quality oocytes can be beneficial to embryo biotechnology researches such as in-vitro fertilization and somatic cell nuclear transplantation.

The invention relates to a preparation method and an application of a substituted benzimino thiazolidone derivative. Specifically, the invention relates to a compound as shown in a formula (I), or an isotope labeled compound thereof, or an optical isomer, a geometric isomer, a tautomer or an isomer mixture thereof, or a pharmaceutically acceptable salt thereof, and application of the compound in preparation of insecticides for pest control. The compound can achieve a better pest control effect at a lower dosage, especially for pests such as tetranychidae, microcosaridae, acaridae, tarsonidae, aleuridae and root-knot nematode, and can be used for controlling pests such as tetranychidae, microcosaridae, gall mite, tarsonidae, aleuridae and the like. # imgabs0 #

The present invention relates to an electrochemical synthesis method of 2-aminothiazole compounds with the structural formula shown below: 1 =4‑Me‑, 3‑Me‑, 2‑Me‑, 4‑Et‑, 4‑MeO‑, 4‑OH‑, 4‑F‑, 4‑Cl‑, 3‑Cl‑, 2‑Cl‑.R 2 =H, Me, Et, Ph. The main process is: in a single-chamber electrolytic cell, ketone (0.589 g, 3 mmol), thiourea (0.076 g, 1 mmol), anhydrous ammonium iodide (0.145 g, 1 mmol), TsOH·H 2 O (0.951g, 5mmol), DMSO (10ml), H 2 O (5ml). Both the cathode and the anode are inserted into graphite sheets, and the current density is 5mA / cm 2 The reaction temperature was 70°C and the current was 3F / mol. The corresponding 2-aminothiazole compound 3 was obtained with a yield of 38-72%.

The invention relates to a composite reverse osmosis membrane acidic cleaning agent, a preparation method and a cleaning process thereof, and belongs to the technical field of environment-friendly water treatment. The cleaning agent comprises the following components in percentage by mass: 4-8% of inorganic acid, 20-40% of organic acid, 1-3% of a surfactant, 0.5-1% of a chelating agent, 0.5-1% of a compound corrosion inhibitor and the balance of deionized water. The composite corrosion inhibitor is formed by compounding 2-mercaptobenzothiazole and the like according to a specific mass ratio, the molecular weight of polyaspartic acid is 5000, and the molar ratio of Zn to Mo in the zinc-molybdate compound is 2: 1. The preparation method comprises the following four steps: firstly preparing a compound corrosion inhibitor premix, then preparing an acidic base solution, and then sequentially adding the components to finally obtain the cleaning solution. According to the cleaning process, a cleaning agent and deionized water are mixed, the membrane flux recovery rate is larger than or equal to 85% through cleaning of a specific process, the reverse osmosis membrane can be effectively cleaned, and the performance of the reverse osmosis membrane can be recovered.

The invention discloses a photoelectric device, a preparation method thereof and a display device, and relates to the technical field of display. The photoelectric device comprises an anode, a functional layer and a cathode which are stacked. The material of the functional layer comprises a doped corrosion inhibitor, and / or a first corrosion inhibition layer is arranged between the anode and the functional layer, and the material of the first corrosion inhibition layer comprises a first interface corrosion inhibitor; the doping corrosion inhibitor and the first interface corrosion inhibitor respectively comprise one or more of a thiazole compound and a cyclic sulfydryl compound. The photoelectric device provided by the invention is good in corrosion resistance.

Provided are mesoionic pyrido[1,2-a]pyrimidine compounds having a 1,2,4-oxadiazole structure, stereoisomers thereof, salts thereof, or solvates thereof, which have a simple structure and production process and are low in production cost. Specifically, for example, 1-((2-chlorothiazol-5-yl)methyl)-3-(3-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)-4-oxo-4H-pyrido[1,2-a]primidinium-1-one salt (Z1) is shown.

The invention relates to the technical field of bactericides, and discloses an oilfield flooding bactericide containing plant bactericidal components and a preparation method thereof. The preparation method comprises the following steps: loading the plant-based traditional Chinese medicine extract and the isothiazolinone-based corrosion inhibitor on the silver-loaded cyclodextrin metal organic framework to prepare an antibacterial agent / silver-loaded cyclodextrin metal organic framework composite material, and mixing the antibacterial agent / silver-loaded cyclodextrin metal organic framework composite material with methyl methacrylate to prepare the antibacterial agent / silver-loaded cyclodextrin metal organic framework composite material. The bactericide obtained by carrying out copolymerization reaction on modified hydroxyquinoline, vinyl quaternary phosphonium salt and methacrylic acid through an in-situ polymerization method can effectively kill and inhibit the breeding of sulfate reducing bacteria and other bacteria in oilfield reinjection water, and has a certain corrosion inhibition effect.

The invention relates to a method for synthesizing 1, 2-allene ketone, and discloses a method for synthesizing 1, 2-allene ketone by taking eneyne, 1, 4-dihydropyridine and benzoyl fluoride as substrates, 2, 4, 5, 6-tetra (diphenylamino)-isophthalonitrile as a photocatalyst, 5, 6, 7, 8-tetrahydro-3-(2, 6-diisopropyl phenyl)-4H-cycloheptyl thiazole perchlorate as N-heterocyclic carbene, cesium carbonate as alkali and acetonitrile as a solvent through a one-pot method. And reacting at room temperature for 4 hours under visible light of 12W and 460nm LED blue light to obtain allene ketone. The reaction conditions are mild, and the method has good functional group tolerance.

The invention discloses an application of a thiazole thioketone compound in chemical copper plating and a chemical copper plating solution, and belongs to the technical field of chemical plating. The thiazole thioketone compound with the structure shown in the formula I and the nitrogen-containing heterocyclic compound are combined to be used for chemical copper plating, the deposition speed of the chemical copper plating solution can be increased, the chemical copper plating solution has excellent stability, meanwhile, the electroplating hole filling effect after chemical copper plating can be improved, and correspondingly, the prepared chemical copper plating solution has good bath solution stability, and the chemical copper plating solution can be applied to chemical copper plating. When the copper plating solution is applied to a chemical copper plating method, the deposition rate of chemical copper plating and the compactness of a plating layer can be effectively improved. # imgabs0 #

The invention provides a thiazolidinone compound and application thereof in preparation of drugs for resisting staphylococcus aureus infection. The molecular structural formula of the thiazolidinone compound is shown as a formula (1), a formula (2), a formula (3) or a formula (4). The technical scheme of the invention discloses several thiazolidinone compounds, which not only have an excellent bactericidal effect on staphylococcus aureus and can significantly inhibit the formation of a biofilm of staphylococcus aureus, but also have low cytotoxicity and hemolytic activity. According to the technical scheme, a certain foundation is laid for research and development of novel staphylococcus aureus biofilm infection resisting drugs, and the potential of thiazolidone derivatives for developing novel antibacterial agents for staphylococcus aureus related infection can be deeply known possibly.

The invention relates to solid compositions comprising {2-[3-cyclohexyl-3-(trans-4-propoxy-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid, and methods of making and using such solid compositions.

According to the method for recycling the waste lithium ion battery positive electrode material aluminum foil, double-bond addition is conducted on ureido of allylurea and maleimide, meanwhile, thiazolecarboxylic acid amino cyclization is conducted, ternary heterocyclic molecules containing ureido, thiazole rings and carboxyl are generated, S atoms, N atoms and O atoms form tridentate coordination sites, and the leaching rate of aluminum is increased.

The invention discloses a P / N / S-containing DOPO (9, 10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide) derivative flame retardant for a V0-grade insulating material as well as a preparation method and application of the flame retardant, and belongs to the technical field of The method comprises the following steps: in a solvent, carrying out a reaction on furfural and 2-amino-5-ethylbenzothiazole at 60-80 DEG C; after the reaction is completed, obtaining an intermediate product, and then adding DOPO; reacting at 80-100 DEG C to obtain a flame retardant; the molar ratio of the furfural to the 2-amino-5-ethylbenzothiazole is 1: (1-2), and the molar ratio of the DOPO to the intermediate product is 1: (1-2). The flame retardant is used in epoxy resin taking 4, 4 '-diaminodiphenylmethane as a curing agent. The flame retardant contains phosphorus, nitrogen and sulfur, can realize phosphorus-nitrogen-sulfur synergistic flame retardance, and has a good flame retardant effect after being applied to an epoxy resin material. The release of heat and smoke in the combustion process of the epoxy resin can be effectively inhibited, the formation of a carbon layer is promoted, and the flame retardant property is remarkable.

The invention discloses a preparation method of a dotenorad key intermediate, and belongs to the technical field of compound synthesis. In the preparation method of the dotenorad key intermediate, provided by the invention, 2-aminothiophenol and formaldehyde are used as raw materials to carry out cyclization reaction to prepare a compound as shown in a formula 1, and then the compound as shown in the formula 1 and 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3 According to the method, 3-(3, 5-dichloro-4-methoxybenzoyl chloride)-2, 3-dihydro-1, 3-benzothiazole is used as a raw material, an amidation reaction is carried out on 3, 5-dichloro-4-methoxybenzoyl chloride in an aqueous solution of an organic solvent, and the key intermediate 3-(3, 5-dichloro-4-methoxybenzoyl)-2, 3-dihydro-1, 3-benzothiazole of dotenorad can be effectively prepared; the obtained dotenorad key intermediate is relatively high in yield and purity; moreover, benzothiazoline which is widely used in the prior art does not need to be used in the preparation method, an activating agent or a solubilizer does not need to be used, the operation method is simple, reaction conditions are mild, and the method is suitable for actual industrial production.

The invention provides a D-A type organic fluorescent small molecule, a preparation method and application of the D-A type organic fluorescent small molecule in detection of nitrofuran antibiotics, and belongs to the technical field of fluorescent sensing. The D-A type organic fluorescent micromolecule is composed of 2-(2-aminophenyl) benzothiazole and an electron-donating group, the excitation spectrum of the D-A type organic fluorescent micromolecule is obviously overlapped with the absorption spectrum of nitrofuran antibiotics, and fluorescence quenching response can be shown through the inner filter effect; the trace nitrofuran antibiotics can be detected in a liquid phase in an ultrafast, high-sensitivity, excellent-selectivity and strong-anti-interference manner. According to the invention, a quantitative evaluation system can be constructed in combination with a smart phone, the RGB value of the image of the liquid-phase fluorescence sensor is output in real time, and rapid, accurate and visual quantitative detection of nitrofuran antibiotics in a real food sample or a water source is realized. In addition, the filter paper fluorescence sensor has the advantages of being portable and easy to prepare, and nitrofuran antibiotics can be rapidly identified on site in an actual scene.

The present disclosure provides compounds having the structure of Formula (I) and pharmaceutically acceptable salts thereof, wherein X1, R1, R2, R3, R4, R5 and R6 are as defined in the specification; pharmaceutical compositions comprising such compounds and salts; the use of such compounds and salts for the treatment or prevention of prolyl endopeptidase fibroblast activation protein (FAP) mediated disorders; kits comprising such compounds and salts; and processes for preparing such compounds and salts. # imgabs0 #