724 results about "Thiazole" patented technology

The invention discloses an isothiazolinone non-curing coating and a preparation method thereof, and relates to the technical field of waterproof coatings. The coating comprises a base material, a compound isothiazolinone antibacterial agent, a mixed stabilizer, a compound plasticizer, a compound anti-aging agent, a filler, an adhesion promoter and a solvent, the compound type isothiazolinone antibacterial agent is prepared by mixing and compounding 2-methyl-4-isothiazolin-3-ketone and 5-chloro-2-methyl-4-isothiazolin-3-ketone according to a mass ratio of (1 to 3): 1, and the compound type isothiazolinone antibacterial agent is prepared by mixing and compounding 2-methyl-4-isothiazolin-3-ketone and 5-chloro-2-methyl-4-isothiazolin-3-ketone and 5-chloro-2-methyl-4-isothiazolin-3-ketone; the mixed stabilizer is formed by mixing organic bentonite, polyamide wax and fumed silica; the defects that an existing non-curing coating is poor in antibacterial performance, insufficient in aging resistance and poor in formula compatibility are overcome.

The invention relates to the technical field of sewage treatment, in particular to a preparation method of a degradable bactericide for an oil field. According to the invention, a hydroxypropyl guanidine gum-polycaprolactone-ethylenediamine fragment copolymer is taken as a carrier, a methylisothiazolinone quaternary ammonium salt (Q-MIT) bactericide is loaded, and the degradable bactericide for the oil field is obtained by cooperating with a dodecyl ethyl sulfide (TC-SE) bactericide and combining with sodium polyaspartate. A carrier forms a hydrogen bond with a polar group on the surface of a biological membrane through a hydroxypropyl guanidine gum main chain to realize targeted anchoring, a polycaprolactone branched chain encapsulates Q-MIT through a hydrophobic effect, primary amino groups of ethylenediamine are introduced to form a pH sensitive Schiff base bond with Q-MIT, and the primary amino groups and adipic dihydrazide form a thermal response hydrazide bond to construct a dual dynamic covalent bond, so that controlled release of Q-MIT is realized, and the biomembrane is prepared. And moreover, the components of the whole system are connected through degradable chemical bonds, so that the environmental protection property and sustainability of oil field operation are guaranteed.

The invention relates to the technical field of organic photoelectric materials, and particularly discloses a non-condensed ring small molecule acceptor material based on a quinonoid structure as well as a preparation method and application of the non-condensed ring small molecule acceptor material. According to the invention, easily available 1, 4-diacetyl piperazine-2, 5-diketone is used as a center, an alkyl chain and Ar are used for modification, EG is used as an end group, the non-condensed ring A-D-A '-D-A type structure acceptor material based on a quinone structure is constructed, and the general formula is shown in the specification. Wherein the PCE of the acceptor material which is modified by bithiophene and takes 2-(3-ethyl-4-oxothiazolidine-2-subunit) malononitrile as a terminal group reaches 15%. The non-condensed ring small molecule acceptor material based on the quinonoid structure is simple in synthesis process, and an effective strategy is provided for solving the problem of the overall performance of an organic solar cell.

The invention relates to a diptera adult insecticide, which contains an insecticidal functional component n-butyl alcohol. According to the invention, n-butyl alcohol which has an obvious poisoning effect on the adult cucurbita petiolatus is separated from a metabolite of a bacillus thuringiensis XLB2910 strain, and 2, 3, 5-trimethylpyrazine and benzothiazole which have an obvious poisoning effect on the adult aedes albopictus are also separated from the metabolite of the bacillus thuringiensis XLB2910 strain. Through poisoning concentration analysis of different components and a compound combination experiment, a series of pesticides for adult cucurbita petioles and adult aedes albopictus are formed, the prepared compound pesticide for cucurbita petioles comprises 2.5%-10% of 2, 3, 5-trimethylpyrazine, 2%-10% of benzothiazole and 5%-10% of n-butyl alcohol, and the prepared compound pesticide for aedes albopictus comprises 2.5%-10% of 2, 3, 5-trimethylpyrazine, 2%-10% of benzothiazole and 5%-10% of n-butyl alcohol. The composition comprises 0.5%-3% of 1, 3, 5-trimethylpyrazine, 0.05%-1.5% of benzothiazole and 1%-3% of n-butyl alcohol. The compound insecticide has a good insecticidal effect on cucurbita petiolatus adults and aedes albopictus adults, and is wide in raw material source and environment-friendly.

The invention discloses a tetrahydrocarbazole enhanced fluorescent probe for detecting hydrosulfite as well as a preparation method and application of the tetrahydrocarbazole enhanced fluorescent probe. The fluorescent probe is a 2-(2-(5-(2, 2-dimethyl-2, 3, 4, 9-tetrahydro-1H-1, 3-methyl carbazole-6-yl) furan-2-yl) vinyl)-3-ethyl benzothiazole-3-onium iodised salt compound, namely, TC-FV-BT, and the fluorescent probe can be applied to the field of fluorescence detection. The probe TC-FV-BT can be used for specifically recognizing the hydrosulfite. Under sunlight, after bisulfite is added into a DMF / H2O (2: 8, v / v) solution of the probe TC-FV-BT, the color of the solution is changed from dark pink to white, under irradiation of ultraviolet light with the wavelength of 365 nm, the solution emits orange fluorescence at the emission wavelength of 605 nm, the fluorescence color of the solution is changed from colorless to orange, the response time is 4 min, the detection limit of the bisulfite reaches 77.27 nM, and the detection limit of the bisulfite reaches 77.27 nM. The fluorescent probe shows good selectivity and anti-interference performance, and has a good application prospect in the fields of environmental analysis, food and the like as a fluorescent probe for detecting hydrosulfite.

The invention belongs to the technical field of building materials, and discloses a special emulsion for large-particle-size high-air-permeability soft porcelain and a preparation method and application thereof, and the emulsion comprises a seed phase, a core emulsion phase, a hard-shell pre-emulsion phase, an initiation system and a post-treatment auxiliary agent; the core emulsion phase comprises deionized water, 2-ethylhexyl acrylate, glycidyl methacrylate, a toughening aid, ethyl phosphate methacrylate and an OP-10 emulsifier; the toughening aid is a polyether-polyester block copolymer; the post-treatment auxiliary agent comprises an antibacterial flame retardant, an organic silicon defoaming agent and ammonia water, the antibacterial flame retardant is a benzisothiazolinone derivative containing phosphorus and nitrogen, performance complementation is achieved through the layered design of a core-shell structure, and meanwhile the stability and adhesive force are improved by means of the reactive emulsifier and the functional monomer; in addition, the polyether polyester block type reactive toughening aid and the phosphorus and nitrogen-containing benzisothiazolinone derivative antibacterial flame retardant are added, so that synergistic optimization of toughening, antibacterial and flame retardant is realized.

This invention discloses an analytical method for benzothiazole contaminants, comprising the following steps: detection by high performance liquid chromatography (HPLC), with the following chromatographic conditions: a phenylhexyl column as the stationary phase, mobile phase A being water, mobile phase B being acetonitrile, and gradient elution; wherein the benzothiazole contaminants are at least one of 2-aminobenzothiazole, 2-hydroxybenzothiazole, benzothiazole, 2-methylbenzothiazole, 2-mercaptobenzothiazole, 2,5-dimethylbenzothiazole, 2-cyanobenzothiazole, ethyl 2-carboxylate benzothiazole, 2-chlorobenzothiazole, 2-bromobenzothiazole, 2-methylthiobenzothiazole, phenylthiocyanate, N-tert-butyl-2-benzothiazole sulfenamide, 2-(2-hydroxyphenyl)-benzothiazole, N-cyclohexyl-2-benzothiazole sulfinamide, dibenzothiazole disulfide, and N,N-dicyclohexyl-2-benzothiazole sulfonamide.

The application belongs to the technical field of organic synthesis, and particularly relates to a preparation method of 5-chloro-2-methyl-4-isothiazoline-3-ketone. N,N'-dimethyl-3,3'-dithiodipropionamide is mixed with ethyl acetate, cooled to 8-10 DEG C, and chlorine is added in stages, and the reaction is continued after the chlorine is passed; the adding mode of the chlorine is as follows: in the first stage, 25-30% of the chlorine is passed in 0.5h while maintaining the temperature of the reaction system at 10-12 DEG C; in the second stage, 25-30% of the chlorine is passed in 1h while maintaining the temperature of the reaction system at 13-14 DEG C; and in the third stage, the remaining chlorine is passed in 1.5h while maintaining the temperature of the reaction system at 15-18 DEG C. The application controls the generation of 5-chloro-2-methyl-4-isothiazoline-3-ketone by controlling the adding amount of the chlorine and the reaction temperature, and improves the yield of 5-chloro-2-methyl-4-isothiazoline-3-ketone.

The present application relates to a kind of five-ring thiazole indole ketone piperazine amide derivatives and purposes thereof.The derivatives take ethyl cyanoacetate as starting material, generate hydroxylamine compound (A) under the action of sodium nitrite and phosphoric acid;Obtain 2-amino ethyl cyanoacetate (B) by reduction, in turn with acetic anhydride, lawson reagent is reacted, and 5-amino-4-carboxylate thiazole compound (D) is obtained;After bromination by NBS, under the catalysis of phosphorus oxychloride, react with tetrahydropyridine indole ketone, generate 2-bromo-6,7-dihydrothiazolo [5'',4'':4',5'] pyrimido [1',2':1,2] pyrindo [3,4-b] indole-4 (12H) -ketone (F), again under alkaline condition, first with Boc piperazine, then by Boc treatment and obtain compound (H);Finally, react with acyl chloride, and 28 different substitution structures of five-ring thiazole indole ketone piperazine amide compound (I1-I28) are synthesized.The 28 compounds are tested on three kinds of cancer cells, and the results show that: 28 compounds have significant inhibitory activity on Hela cervical cancer cells, HT-29 human colon cancer cells and HGC-27 human gastric cancer cells.

This invention belongs to the field of nanopesticides, and specifically relates to the preparation of suspensions and dispersions of pesticide varieties that are insoluble in water and solvents, with particle sizes smaller than 100 nanometers, especially smaller than 50 nanometers. The thiamethoxam zinc nanoparticle suspension and dispersion described in this invention is formed by diluting and mixing two or three components with water.

The application discloses a thiazole / oxazole group-containing 1,2,4-triazole derivative, a preparation method and application thereof, and relates to the technical field of medicinal chemistry.The thiazole / oxazole group-containing 1,2,4-triazole derivative has excellent broad-spectrum antifungal effect and the advantage of a simple synthesis method, and has important reference significance for developing a novel high-efficiency antiplant pathogenic fungus agent.

The invention relates to the technical field of anti-cancer chemical drugs, in particular to a thiadiazole tetranuclear copper complex with anti-tumor and antibacterial activity and a preparation method and application of the thiadiazole tetranuclear copper complex. The chemical formula of the complex is [Cu4 (C3H3S2N2) 2 (C3H4S2N2) 4], the complex is synthesized from ligand thiadiazole and CuX, X is I or Br, and copper in the obtained complex is + 1 valence. The complex shows a good cytotoxic effect on breast cancer cells MCF-7, is likely to play a toxic effect by inducing apoptosis, ferroptosis, copper death and other ways, has a good antibacterial effect, has potential medicinal value, and is expected to be developed into a new generation of anti-tumor drugs with antibacterial properties.

The application discloses a nematicidal composition and application thereof, wherein the composition contains active ingredient A and active ingredient B, the weight ratio of the active ingredient A to the active ingredient B is 1:50-50:1, the active ingredient A is a compound shown as a formula I, and the active ingredient B is a nematicidal thiazole. The nematicidal composition is used for preventing and treating plant parasitic nematodes, has good nematicidal activity, and has little toxicity to human and animals.

This application relates to a terphenylamine skeleton compound, its preparation method, and its application, belonging to the field of chemical synthesis technology. The preparation method of the terphenylamine skeleton compound of this application includes the following steps: dissolving 2,4,6-triphenylaniline with thiazole-4-carboxaldehyde or thiophene-3-carboxaldehyde in a solvent, conducting a reductive amination reaction under reducing agent conditions, quenching, extraction, washing, concentration to remove solvent, and purification to obtain the terphenylamine skeleton compound. This application provides a simple and mild synthetic method for the natural active products 5'-phenyl-N-(thiazol-4-ylmethyl)-[1,1':3',1''-terphenyl]-2'-amine and 5'-phenyl-N-(thiophene-3-ylmethyl)-[1,1':3',1''-terphenyl]-2'-amine, which can only be extracted from the secondary metabolites of the marine fungus Aspergillus sp. Furthermore, this method utilizes widely available raw materials, which is beneficial for large-scale industrial production of these natural active products.

This invention relates to the field of pesticide technology, specifically to a fungicidal composition, its preparation method, and its uses. The invention provides a fungicidal composition comprising an active ingredient, a first functional component, a second functional component, and an adjuvant; the active ingredient comprises fluthiazopyrone and cyazofamid; the first functional component comprises at least one selected from silica, titanium dioxide, and zinc oxide; the second functional component comprises at least one selected from citric acid, acetic acid, benzoic acid, urea, and triethanolamine. By introducing specific first and second functional components, this invention synergistically works with the active ingredient, effectively overcoming the key defects of fluthiazopyrone's easy photodegradation and cyazofamid's easy hydrolysis, thus improving the stability of the compound formulation; while ensuring the excellent control efficacy and resistance management advantages of both against oomycete diseases such as grape downy mildew, it extends the duration of action and weather resistance of the agent, providing a more stable, efficient, and long-lasting solution for field application.

The present invention relates to chemical compounds useful as inhibitors of class II phosphoinositide 3-kinase (PI3K) signaling. The invention further relates to the medical use of inhibitors of class II phosphoinositide 3-kinase (PI3K) signaling in the treatment of medical conditions associated with defective and / or pathological class II phosphoinositide 3-kinase (PI3K) signaling, such as stroke, cardiovascular diseases associated with endothelial cell dysfunction, cancer, cancerometastasis, myopathy and diabetes.

This invention provides the medical use of tyrosol in the preparation of formulations that reduce the toxicity of penicillin-thiazolic acid (PTA). It discloses a novel medical use of tyrosol in preparing formulations that reduce PTA toxicity. By using tyrosol to prevent and treat the residual toxicity of PTA, unnecessary antibiotic replacement regimens can be avoided, significantly reducing the economic burden. A method for preventing and treating PTA residual toxicity is provided, which can significantly reduce the toxicity of PTA and has good preventive and therapeutic effects. The prevention and treatment of PTA residual toxicity has significant socio-economic implications for controlling the hygiene and quality of animal-derived foods, protecting consumer health, and ensuring industrial production.

The present application relates to the technical field of agricultural chemistry, in particular to butenolide compounds containing a thiazolidinone structure as well as a preparation method therefor and the use thereof. The butenolide compounds containing a thiazolidinone structure are characterized by having the following structural general formula (I). The compounds disclosed by the present application have excellent fungicidal activity on various pathogens in agriculture or other fields, and can favorably protect important crops and domestic animals in agriculture and horticulture industry, and the environment that the human beings rely on from invasion of pathogens.

An attractant for Telenomus remus Nixon to control Spodoptera litura Fabricicus is provided. The attractant includes a solvent and at least one of the following components: 1,3-dichlorobenzene, benzothiazole, and octane. The attractant can effectively attract Telenomus remus Nixon to parasitize Spodoptera litura Fabricius eggs, such that the growth of a pest quantity is inhibited and the pest population gradually dies out, which achieves the purpose of pest control. The attractant is a green, non-toxic, and pollution-free attraction substance. Therefore, the attractant can solve a series of problems such as pesticide residues, environmental pollution, and food safety caused by chemical control, and is of great significance for the green control of Spodoptera litura Fabricius.

The invention discloses a flexible glass cutting fluid and a preparation method thereof, and the preparation method comprises the following steps: S1, adding cellobiose into DMF, then adding chloroacetic anhydride and pyridine, and carrying out a stirring reaction to obtain an intermediate; s2, adding the intermediate into DMF (Dimethyl Formamide), and then carrying out constant-temperature reaction on glycerol monocaprylate, 2-(2-hydroxyphenyl) benzothiazole and triethylamine to obtain a modifier; s3, uniformly mixing a modifier, sodium dioctyl sulfosuccinate and a polyoxyethylene polyoxypropylene block copolymer, so as to obtain a composite surfactant; s4, adding the composite surfactant, the propylene glycol, the defoaming agent, the sterilizing agent and the triethanolamine into the water, and uniformly stirring to obtain the cleaning agent. According to the prepared cutting fluid, the protection effect on a flexible glass base material and a surface functional layer of the flexible glass base material is remarkably improved while the excellent wettability is kept, microcrack generation and surface damage in the cutting process are reduced, and the cutting fluid is particularly suitable for precise glass processing of flexible display devices.

The present application provides novel compounds that inhibit MYLK4 activity and their medical use. A compound of Formula (I) or a pharmaceutically acceptable derivative thereof is provided: (in the formula, R 1 to R 5 each independently is hydrogen or a C 1‑3 linear aliphatic hydrocarbon; R 6 a 5- to 10-membered aromatic hydrocarbon optionally substituted, a 5- to 10-membered heterocycle optionally substituted having 1 to 5 heteroatoms independently selected from nitrogen, oxygen, and sulfur as ring constituent atoms, or a condensation ring of any of the foregoing with a 4- to 10-membered heterocyclic group optionally substituted having 1 to 3 heteroatoms independently selected from nitrogen, oxygen, and sulfur as ring constituent atoms), and the like as medicines.

The invention relates to a process for preparing 1,2′-benzisothiazoline-3-one according to formula (I), comprising the following steps: (a) reacting a 2-halogenbenzonitrile compound of general formula (II) with a reaction mixture, containing: (i) alkaline sulphide and / or alkaline hydrogen sulphide and (ii) an alkyl halide compound, represented by general formula (III): R1X (III) for producing an intermediate product of general formula (IV), and (b) reacting the intermediate product of general formula (V) obtained in step (a) with a halogenating agent or an oxidant and subsequent reaction of the 2-(alkylsulfoxy)benzonitrile with an acid to form 1,2-benzisothiazoline-3-one as well as a halide compound of general formula (V) R1X (V).

The invention relates to the technical field of organic chemistry, and particularly discloses an amide derivative containing a thiazole oxime structure as shown in a general formula 8 and a preparation method and application of the amide derivative. The derivative shows remarkable antibacterial activity on staphylococcus aureus, escherichia coli, pseudomonas aeruginosa and fluoroquinolone-resistant escherichia coli, particularly has a remarkable effect on gram-negative bacteria, has broad-spectrum antibacterial potential and can be used for preparing drugs for treating related bacterial infection, and the activity of part of compounds is superior to that of a control drug.

The present disclosure discloses a lurasidone hydrochloride oral film composition, preparation method and use thereof. The present disclosure discloses the lurasidone hydrochloride oral film composition including an active pharmaceutical, a film-forming material, a plasticizer and a flavoring agent, wherein the active pharmaceutical is (3aR,4S,7R,7aS)-2-((1R,2R)-2-[4-(1.2-benzisothiazol3-yl)piperazine-1-methyl]cyclohexylmethyl)hexahydro-4.7-methylene-2H-isoindole-1,3-dione hydrochloride denoted by the following formula I. The lurasidone hydrochloride oral film composition of the present disclosure has a good dissolution rate, a uniform appearance, a good flexibility, and a uniformity content meeting the requirement. Moreover, during the preparation process of the film liquid of the composition, sedimentation of the film will not occur. After the composition is dissolved in the user’s mouth, the user does not have any gritty feeling.

The present invention relates to a novel crystalline form of a helicase-primase inhibitor compound, and to pharmaceutical compositions comprising the novel crystalline form, to methods of production of the novel crystalline form, to the crystalline form in medicine and for use in the treatment of herpes viral infections.

The invention relates to application of (E)-2-(4-(dimethylamino) styryl)-6-methoxy-3-methylbenzo [d] thiazole-3-onium in preparation of anti-cancer drugs, and belongs to the technical field of medical application, the structure of (E)-2-(4-(dimethylamino) styryl)-6-methoxy-3-methylbenzo [d] thiazole-3-onium is as shown in the following formula I, the (E)-2-(4-(dimethylamino) styryl)-6-methoxy-3-methylbenzo [d] thiazole-3-onium can inhibit the growth of gastric cancer cells, inhibit the proliferation, invasion and migration of the gastric cancer cells by promoting the autophagy and mitochondrial rupture of AGS and HGC-27 cells of the gastric cancer cells, and block the gastric cancer cells in the G1 stage. Furthermore, in-vivo experiments of mice prove that ZWK-3 can inhibit tumor growth of the mice, shows obvious dose dependence, and does not influence the body weight and visceral indexes of the mice at the same time. Formula I.

The invention relates to a method of producing a food composition comprising microalgal biomass with reduced off-flavour, said method comprising adding at least 0.001 wt.%, calculated by weight of the food product, of an aldehyde scavenger, said aldehyde scavenger containing at least 5 wt.%, calculated by weight of the aldehyde scavenger of cysteine. The invention also relates to Food composition comprising microalgal biomass material, said material comprising at least 5 wt% of microalgal protein by weight of dry matter of the microalgal biomass, and 2-pentyl-1,3-thiazolidine-4-carboxylic acid and / or salts thereof, and optionally, water. The invention also relates to a food composition comprising microalgal biomass material, comprising at least 5 wt% of microalgal protein by weight of dry matter of the microalgal biomass; hexanal or a source of hexanal; and at least 0.001 wt.%, calculated by weight of the food product, of an aldehyde scavenger, said aldehyde scavenger containing at least 5 wt.%, calculated by weight of the aldehyde scavenger of cysteine.