4675 results about "Thiazole" patented technology

There is provided a novel compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity. The present invention provides an imidazothiazole derivative represented by the following formula (1) having various substituents that inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity:

wherein R¹, R², R³, R⁴, and R⁵ in the formula (1) each has the same meaning as defined in the specification.

The invention relates to processes for preparing compounds having the formula,

• • and crystalline forms thereof, wherein Ar is aryl or heteroaryl, L is an optional alkylene linker, and R₂, R₃, R₄, and R₅, are as defined in the specification herein, which compounds are useful as kinase inhibitors, in particular, inhibitors of protein tyrosine kinase and p38 kinase.

A coating composition used for coating of a steel material and/or aluminum material comprises a corrosion inhibitor, a base resin and a curing agent. The corrosion inhibitor may be selected from cerium compounds, lanthanum compounds, molybdate salt compounds, gluconic acid derivative salts, porous base materials, triazole compounds, thiazole compounds, tetracyclines, and metal phosphate salt compounds of ascorbic acid. The base resin may include a xylene-formaldehyde-resin-modified amino-containing epoxy resins obtained by reacting an epoxy resin having an epoxy equivalent of from 180 to 2500 with a xylene formaldehyde resin and an amino-containing compound. The curing agent may be a blocked polyisocyanate compound obtained by blocking an isocyanate group of a polyisocyanate compound with a blocking agent.

The invention relates to processes for preparing compounds having the formula,

and crystalline forms thereof, wherein Ar is aryl or heteroaryl, L is an optional alkylene linker, and R₂, R₃, R₄, and R₅, are as defined in the specification herein, which compounds are useful as kinase inhibitors, in particular, inhibitors of protein tyrosine kinase and p38 kinase.

The invention belongs to the technical field of pesticide formulation and in particular relates to a composite bactericidal composite and applications thereof in aspect of preventing and curing the fungicidal and bacteria diseases of grains, fruits and vegetables. The composite bactericidal composite comprises effective ingredient A and B, wherein the effective ingredient A is prochloraz or othermetal salt composite, and the effective ingredient B comprises at least one of penconazole, imazalil sulfate, ethirimol, bupirimate, SYP-Z048, thifluzamide, mandipropamid, ethaboxam, polyoxin, polyoxin B, benziothiazolinone, famoxadone, dithianon and zinc thiazole. The composite has high efficiency, low toxicity, low residue, good environment compatibility and low cost.

A material for making elastomeric nitrile rubber articles is disclosed. In particular, the process and material formulation can produce nitrile rubber based articles, which exhibit force-strain characteristics that are comparable to those of natural rubber latex articles, while maintaining the tensile strength properties of nitrile rubber. The process includes an accelerator composition at the pre-cure stage having a dithiocarbamate, a thiazole, and a guanidine compound. The invention also includes an elastomeric nitrile rubber product made by the process, such as examination, surgical, or work gloves, which can have an exterior coating over naked rubber selected from either a silicone emulsion or oil, glycerin solution, a combined mixture of silicone and glycerin/glycerol, a fluorocarbon release agent, or a natural or synthetic hydrocarbon-based oil in amounts that do not degrade said substrate rubber material.

The present invention relates to an organic electroluminescent device comprising a substrate, a cathode, at least two organic material layers comprising a light-emitting layer, and an anode in the sequentially laminated form, in which the organic material layers comprise an organic material layer comprising a compound having a functional group selected from the group consisting of an imidazole group, an oxazole group and a thiazole group between the cathode and the light-emitting layer. The organic electroluminescent device according to the present invention comprises an organic material layer comprising a compound having a functional group selected from the group consisting of an imidazole group, an oxazole group and a thiazole group between a cathode and a light-emitting layer, thus having an improved electron injection characteristic to provide an organic electroluminescent device of an inverted structure operating at a low voltage.

Abstract of Disclosure The invention relates to compounds for topically influencing the activity of dipeptidyl peptidase of the general formula wherein A is an amino acid having at least one functional group in the side chain;B is a chemical compound covalently bound to a functional group of the side chain of A, chosen from the group consisting of (a) oligopeptides having a chain length of up to 20 amino acids, (b) homopolymers of glycine consisting of up to 6 glycine monomers, and (c) polyethylene glycols having molar masses of up to 20 000 g/mol; and C is a group amide-bonded to A chosen from the group consisting of thiazolidine, pyrrolidine, cyanopyrrolidine, hydroxyproline, dehydroproline or piperidine. The invention further relates to the use of said compounds for targeted intervention in local immunological processes (chemotaxis, inflammatory processes, autoimmune diseases), as well as effective and targeted treatment of pathophysiological and physiological processes related thereto (psoriasis, periodontitis, arthritis, allergies, inflammation), inter alia.

The present invention discloses a medicine with actions of resisting plant virus and resisting tumor-N-substituted benzothiazolyl-1-substituted phenyl-0.0-dialkyl-alpha- aminophosphonates derivative, its preparation method and biological activity. Said invention also provides its structure formula, and also provides its extensive application for inhibiting tobacco mosaic virus (TMV) activity and inhibiting activity of human body prostatic cancer cell PC3 and others.

The invention provides a fungicide composition containing an active component A and an active component B, and application thereof in preventing and controlling various agricultural fungal diseases. The active component A in the composition is one of two methoxyl acrylic ester compounds; and as shown above, the active component B of the compound A1 and the compound A2 is one of the following fungicide varieties: thiocarbamate compounds or salt thereof, aliphatic compounds or salt thereof, carbamate compounds or salt thereof, oxazole compounds or salt thereof, thiazole compounds or salt thereof, amide compounds or salt thereof, organophosphorus compounds or salt thereof, imidazole compounds or salt thereof, antibiotic compounds or salt thereof, pyridine compounds or salt thereof and triazole compounds or salt thereof.

The invention provides an organic semiconductor material containing 6-R group-[1, 2, 5] thiazole [3, 4-g] benzotriazole and an application thereof. Diazosulfide is used as parent, benzotriazole derivatives are formed by reduction and ring closure of nitrated diazosulfide, and finally, a halogenated 6-R group-[1, 2, 5] thiazole [3, 4-g] benzotriazole monomer is synthesized by performing alkylation reaction on an H of an N atom; and the monomer is reacted with a monomer containing an aromatic group under effect of metal catalyst to prepare the organic semiconductor material. Positions 1, 2, 5 and 6 of a benzene ring of the organic semiconductor material are respectively connected with alkyl triazole and thiazole, the two kinds of chemical groups have excellent electron attracting performance, and a formed ternary condensed ring has better planarity and conjugated bonds, and also has good dissolubility. The organic semiconductor material provided by the invention can be used as an active layer having application foreground to be applied in organic photoelectric devices.

The invention discloses 4-tert-butyl-5-(1,2,4-triazol-1-yl)-2-benzylimino thiazole (I) having the chemical structural formula shown rightwards. A method for preparing the 4-tert-butyl-5-(1,2,4-triazol-1-yl)-2-benzylimino thiazole is as follows: the step of reflux reaction is carried out on the 4-tert-butyl-5-(1,2,4-triazol-1-yl)-2-aminothiazole and aryl aldehyde in benzene, thereby preparing the 4-tert-butyl-5-(1,2,4-triazol-1-yl)-2-benzylimino thiazole. The 4-tert-butyl-5-(1,2,4-triazol-1-yl)-2-benzylimino thiazole can be used for preparing bactericide.

The present invention relates to an antimicrobial composition comprising an isothiazolinone, such as 1,2-benzisothiazolin-3-one, and a zinc compound selected from zinc salts, zinc oxides, zinc hydroxides or combinations thereof. Useful zinc salts include for example, oxides, sulfates, chlorides, and combinations thereof. In use, the zinc from the zinc compound enhances the antimicrobial activity to the isothiazolin-containing composition. This enhancement permits achieving the desired antimicrobial activity at a lower usage rate than is achieved using the isothiazolinone in the absence of the zinc compound. The antimicrobial composition can also contain co-biocides, such as pyrithiones, including zinc pyrithione or copper pyrithione.

The present invention discloses new quinolone derivatives with 3-position substituted by imidazol radical, benzoxazole and benzothiazole and possessing antitumor activity. The preparation process ofthe compounds is also disclosed.