514results about How to "Improve efficacy" patented technology

The invention provides compositions and methods for treating diseases associated with expression of CD19. The invention also relates to chimeric antigen receptor (CAR) specific to CD19, vectors encoding the same, and recombinant T cells comprising the CD19 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD19 binding domain.

Methods and devices to attenuate tumor necrosis factor (TNF) and other pro-inflammatory mediators in the CNS to treat neurological, neurodegenerative, neuropsychiatric disorders, pain and brain injury are described. More particularly, TNF blocking agents that target intracellular signals and downstream effects associated with the production and secretion of TNF are described. Devices described include therapy delivery devices comprising a reservoir capable of housing a TNF blocking agent and a catheter operably coupled to the device and adapted to deliver the TNF blocking agent to a target site within a subject.

A tissue expansion device, the device comprising: (a) an expandable compartment adapted for implanting in a body of a subject; and (b) a gas source adapted for implanting in a body of a subject and operably connected to said expandable compartment for inflation thereof by transfer of a gas thereto.

A fungicidal composition containing a fungicidally effective amount of a compound of Formula I-V and at least one fungicide selected from the group consisting of epoxiconazole, prothioconazole, azoxystrobin, pyraclostrobin, penthiopyrad, isopyrazam, bixafen, boscalid, prochloraz, and chlorothalonil provides synergistic control of selected fungi.

A polypeptide self-antigen useful in a tumor-specific vaccine mimics one or more epitopes of an antigen uniquely expressed by cells of the tumor. The polypeptide is preferably produced in a plant that has been transformed or transfected with nucleic acid encoding the polypeptide and is obtainable from the plant in correctly folded, preferably soluble form without a need for denaturation and renaturation. This plant-produced polypeptide is immunogenic without a need for exogenous adjuvants or other immunostimulatory materials. The polypeptide is preferably an scFv molecule that bears the idiotype of the surface immunoglobulin of a non-Hodgkin's (or B cell) lymphoma. Upon administration to a subject with lymphoma, the plant-produced, tumor-unique scFv polypeptide induces an idiotype-specific antibody or cell-mediated immune response against the lymphoma.

The present invention relates to methods and compositions for repairing adverse effects of the environment, daily stress, sun exposure, or pre-mature aging on human skin, comprising applying to the skin, prior to a period of bodily rest, a topical composition that contains resveratrol or a derivative thereof and at least one DNA repair enzyme.

A multi-video camera monitoring system based on stereo-video dynamic tracking comprises stereo-video panoramic video camera module with at least two panoramic shooting heads, image collection module for forming digital image series, image processing module for generating 3-D control signal, data communication and control module separately connecting to tracking video camera module and manual controller as well as monitoring center, tracking video camera module for tracking abnormal object. Its tracking method is also disclosed.

The invention discloses the composite of an environment-friendly rice flotable agricultural chemical preparation and a novel manufacture process thereof, which belongs to the field of farm chemical. The preparation is formed by compounding 0.1 to 50 percent of a weed killer, an insecticide, a fungicide or plant growth regulator active ingredients, 0.1 to 30 percent of a micropore sustained release agent, and 99.8 to 20 percent of a floatble carrier according to mass percentage. The preparation can effectively save the active ingredients by more than 70 percent, and can be directly applied on the surface of rice paddy field. The preparation has the characteristics of low cost, high efficacy, lasting drug action, safety, convenient use and so on, and is an environment-friendly agricultural chemical preparation.

Microbicidal compositions containing selected ratios of a non-halogenated 2-alkyl-3-isothiazolone and one or more (C1-C7) esters of para-hydroxybenzoic acid are disclosed as improved formulations for controlling microbial growth. In particular the combination of 2-methyl-3-isothiazolone with a mixture of methyl para-hydroxybenzoate and propyl para-hydroxybenzoate is especially effective as a microbicidal component in personal care compositions.

Oxygenating agents are used in the present invention for the novel purpose of treating microbial infections. The invention takes advantage of the fact that the increase in tissue pO₂ produced thereby can enhance the efficacy of the body's own antimicrobial defenses (including tissue repair), while also improving the efficacy of adjunctive agents that may be co-administered, such as antimicrobial agents, antioxidants, cytokine modulators, endotoxin antagonists and growth factors. The oxygenating agents of the present invention achieve the desired increased pO₂ in the tissues without having to resort to the risks and expenses of hyper-baric oxygen therapy (HBO). The oxygenating agents can be administered systemically, regionally, or topically.

Certain embodiments of the methods and compositions of matter disclosed herein relate to: “simultaneous” control of rodents and at least one insect pest (e.g., cockroach, ant, tick) using the same bait; control of ticks by orally administering to mammals a diet composition comprising fipronil; enhancing insecticide efficacy through use of a diet composition that comprises a Generation-I rodenticide and an insecticide; use of imidacloprid in a diet composition orally administerable to mammals in an uncontrolled setting; and use of at least one insecticide to enhance the efficacy of a rodenticide.

A spray composition for applying to soil, plants or other agricultural substrate containing of at least one member selected from the group consisting of block copolymer of ethylene oxide and propylene oxide. An adjuvant can be a concentrate composition which can be diluted to form a tank mix containing a pesticide. The composition of the invention enhances the efficacy of an agrochemical and is applied through drift reduction nozzles to a desired substrate which can be a plant, soil or crop.

This invention is in the area of improved compounds and methods for treating selected cancers and hyperproliferative disorders.

The invention discloses a Doherty envelope tracking power amplifier and a method for treating a radio frequency signal. The amplifier comprises a power divider, a peak amplifier, a carrier amplifier, a coupler, an envelope extraction unit and a first linear amplification unit, the input end of the radio frequency signal is respectively connected with the input end of the power divider and the input end of the envelope extraction unit by the coupler, the output end of the power divider is respectively connected with the input end of the peak amplifier and the input end of the carrier amplifier, the output end of the carrier amplifier is connected with the output end of the peak amplifier in a coupling way, and the output end of the envelope extraction unit is connected with the grid electrode end of the carrier amplifier by the first linear amplification unit. According to envelope changes of the input radio frequency signal and under the conditions of ensuring the basic changeless output signal gain, the carrier amplifier enables the linearization of output signals to reach real-time optimization and improves the linearization of the output signals of the carrier amplifier, thereby improving the efficacy of the Doherty envelope tracking power amplifier.

This invention relates to a method of identifying individuals with neuropsychiatric disorders or to predict and determine the efficacy of treatment of the disorder by acquiring information about visual scanning behaviour and fluctuations of visual scanning behaviour of individuals comprising presenting to the individual a sequence of visual stimuli, wherein each visual stimulus is comprised of multiple images with specific characteristics, measuring the point-of-gaze of said subject on the visual stimuli and calculating a set of statistical measures that describes the visual scanning behaviour of the individual on images or portion of images with the same characteristics; and making a determination of biases in visual scanning behaviour of the individual, by comparing the statistical measures of the individual to the statistical measures of controls.

A method of reducing hair growth includes topical application of a TRPM8 and/or a TRPA1 agonist, alone or in conjunction with heat.

An extension catheter is introduced through the guide catheter and inserted into the treatment area, The extension catheter may have an expandable tip. A suction pump is coupled to the proximal end of the guide catheter to aspirate blood clots or other issue from the treatment location outside the body.

The present invention provides compounds and assays for the identification and validation of compounds for use in the treatment of spinal muscular atrophy (SMA), in which said compounds up-regulate the post-transcriptional expression of SMN1 or SMN2.

The invention relates to a pneumatic machine which uses wind energy a power. It can be widely used in variable machines driven by the power device. It comprises a wind collection cover, a wind tunnel, a blade wheel, a blade, and an axle. It is characterized in that: the wind collection cover is integrated with the wind tunnel; the wind collection cover has several cyclone guide channel; the end of wind tunnel has an axial support connecting the axle; and the axle has the blade wheel and the blade. The wind energy collected by the wind collection cover and the cyclone guide channel is strong and through the wind tunnel to avoid distributed to generate wind tunnel effect. The invention has one axle and several blade wheels which can rotate in same direction while each two nearby blade wheels may have different rotational directions to avoid layered. The blade has folded angle and a wind discharge outlet with self-protective function to improve the efficiency of invention. The invention has easy operation, while it can improve the efficiency and the rotational speed of blade wheel with better economic and social benefits.

The invention discloses a straw comminution rotary tillage, fertilizing and sowing composite working device, wherein the composite working device is mated with a wheel tractor with more than 75 horsepower and three-point suspension mechanism of the tractor is connected with the three-point suspension rack. The composite working device comprises a stand of frame shape, a crushing cutter, a rotary tillage cutter, a fertilizing and furrowing blade, a sowing boot and a clump pack roller which are mounted in turn below the stand of frame shape, a seed and fertilizer box, a rotary tillage crushing gear box, a main gear box and a suspension rack which are mounted in turn above the stand of frame shape. The composite working device can accomplish multi-job operation at one time, with features of good efficacy, good effect, reduced times of entering into cultivation ground and cultivating, increased soil organic material content and greatly reduced production cost.

The present invention provides compositions and methods for enhancing and improving cell therapies for neurological disorders including Parkinson's disease. Specifically, the present invention provides a cell or cells modified by viral vector compositions that allow for the over-expression and RNAi mediated knockdown of genes in vitro and in vivo. The present invention further provides cell therapy methods for treating or preventing neurodegeneration in a subject, and for protecting neurons from damage in the context of neurodegenerative disorders using the modified cells. Additionally, the present invention provides methods for purification and identification of mature dopamine neurons for cell therapy using fluorescent compounds including JHC1-64.

Nasal pharmaceutical formulations comprising a drug substance having a specific particle size distribution profile are disclosed herein. Such profile provides increased bioavailability, increased efficacy or prolonged therapeutic effect of the drug substance when administered intranasally. The formulations of the present invention may comprise one or more corticosteroids having a specific particle size distribution profile. In a preferred embodiment, the corticosteroid is fluticasone or a pharmaceutically acceptable derivative thereof for the treatment of one or more symptoms of rhinitis. Preferably, the drug substance is fluticasone propionate. The formulations herein may be provided as an aqueous suspension suitable for inhalation via the intranasal route.

Provided herein are methods and compositions and kits related to uricase compositions and/or compositions comprising synthetic nanocarriers comprising an immunosuppressant. Also provided herein are methods and compositions and kits for the treatment of subjects, including subjects with hyperuricemia, gout or a condition associated with gout, and for preventing gout flare.

The present invention advantageously provides a method and system for the improved isolation and corresponding treatment of tissue targeted for cryogenic or other thermal therapy to increase the thermal efficacy and thermal efficiency of the treatment. In particular, the present invention provides methods and systems for improved thermal treatment of target tissue, such as a pulmonary vein and/or regions of the left atrium by reducing the resistive forces and/or increased thermal energy experienced from blood flow exiting the pulmonary vein into the left atrium during treatment.

The invention provides a crystal form, preparing method and application of Olaparib. According to the Olaparib with the new crystal form, CuKa radiation is adopted, powder X-ray diffraction represented by 2 theta angle has diffraction peaks at 22.9+/-0.5, 23.4+/-0.5, 21.0+/-0.5, 17.1+/-0.5, 17.3+/-0.5, 14.2+/-0.5, 15.0+/-0.5, 13.5+/-0.5, 18.6+/-0.5, 20.6+/-0.5, 10.2+/-0.5, 20.3+/-0.5, 21.9+/-0.5, 25.8+/-0.5 and 26.5+/-0.5. The granularity D50 of the Olaparib with the crystal form is 2.45 microns which is quite small, so that dissolving-out speed is high when the Olaparib serves as a preparation, and drug efficacy of a product is improved. Furthermore, the preparing method is simple, and the performance of the obtained Olaparib with the crystal form is stable.

The invention relates to a composition comprising 3-methyl-1-phenyl-2-pyrazoline-5-ketone and borneol, and application thereof in preparing a medicine for treating cerebrovascular diseases, particularly ischemic cerebrovascular diseases. The typical ischemic cerebrovascular disease is cerebral infarction.

An integrated LED device is provided. The LED device includes a substrate. The LED device includes a semiconductor material including a light generating layer and positioned on the substrate. The semiconductor material and/or the substrate are configured to control light internally to output quasi-collimated light from a light emitting surface of the LED device. The LED device includes an optical component positioned at the light emitting surface and configured to receive quasi-collimated light exiting the light emitting surface and to alter one or more optical properties of at least some beams of the quasi-collimated light.

The invention discloses a drug for treating osteoporosis, and particularly relates to an oral dripping pill preparation prepared by adopting calcitriol as raw material. The invention aims at making up the defects that the existing preparation formulation is little and the drug is not stable and providing an oral dripping pill preparation with high bioavailability, fast drug releasing, fast effect, high drug content, good stability of drug, convenient taking and no pollution in production. The calcitriol dripping pill adopts calcitriol as raw material and is prepared with carrier which is pharmaceutically acceptable and used as matrix.

The invention relates to a pesticidal composition containing emamectin benzoate and chlorantraniliprole. The pesticidal composition takes emamectin benzoate and chlorantraniliprole as effective constituents with mass proportion of 10:1 to 1:20 and the mass percentage content of the emamectin benzoate and chlorantraniliprole is between 1 percent and 50 percent. The pesticidal composition is used for preventing resistant insects in agriculture, and particularly used for preventing rice Cnaphalocrocis medinalis and the like.

The present invention is directed to methods and agents that are useful in the prevention and amelioration of signs and symptoms associated with neuropathic conditions. More particularly, the present invention discloses the use of angiotensin II receptor 2 (AT₂ receptor) antagonists for the treatment, prophylaxis, reversal and/or symptomatic relief of neuropathic pain, including mechanical hyperalgesia, thermal or mechanical allodynia, diabetic pain and entrapment pain, in vertebrate animals and particularly in human subjects. The AT₂ receptor antagonists may be provided alone or in combination with other compounds such as those that are useful in the control of neuropathic conditions.