108results about How to "Improve efficacy" patented technology

The invention is about a method of marking ink which is only used to defend fake. The composition of it is: lipidol or lipid, surface active agent, integration agent, water, buffering agent. Their mass percents are: 1,2-hexylene glycol: 5%-15%, butanol: 1-5%, DH-1: 5-10%, EDTA: 0.1-0.5%, MS-1: 0.1-1%, water: the rest. The process is: a. dissolving the colorant in water, b. put the correct percent of 1,2-hexylene glycol and butanol into the solvent, then dropping the MS-1 and EDTA solution when mixing the solvent for 30-50 min, c. put the rest precent of water into the printing ink box. The picture and word would be shown red fluorescence in the UV but blank in the usual light.

The invention discloses an ROS-responsive prostate cancer targeting prodrug as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The prodrug is formed by covalently linking a prostate cancer targeting peptide SYEELR, a ROS (reactive oxygen species) response type ketal thiol (TK) connexon and an active molecule Devimistat. The preparation method comprises the following two steps: firstly, coupling Devimistat with a TK linker to obtain an intermediate Dev-TK, and then coupling the intermediate Dev-TK with an SYEELR peptide fragment to obtain a target product. The prodrug can specifically break and release Devimistat in a tumor high active oxygen microenvironment, and active targeting delivery is realized by virtue of the SYEELR peptide. The invention provides a novel prostatic cancer treatment strategy with accurate targeting, controllable release, enhanced curative effect and toxicity reduction potential.

The invention discloses a nicosulfuron-containing herbicidal composition and application thereof. The herbicidal composition is prepared from the following components: nicosulfuron, amicarbazone, and dimethyltetrachloroisooctyl ester as well as a dispersant, an emulsifier, a wetting agent, a thickening agent, an antifreeze, and a dispersion medium, wherein the dosage form belongs to a dispersed oil suspension agent. Through the combination of the three active ingredients, the herbicidal composition has an obvious synergistic effect, the use amount of pesticides is reduced, the cost and environmental pollution are reduced, the drug resistance of corn field weeds can be delayed by the application of the composition, and the control spectrum is expanded.

This invention discloses a muscle-relaxing and meridian-clearing health powder and its preparation and application methods, belonging to the technical field of traditional Chinese medicine external health care products. The health powder is composed of fifteen raw medicinal materials: safflower, angelica, asarum, kudzu root, red peony root, scutellaria, dragon's blood, saposhnikovia root, frankincense, myrrh, cinnamon twig, mugwort leaf, coptis root, *Lycopodium clavatum*, and *Clematis armandii*. These materials are dried, pulverized to 80-120 mesh, and then evenly mixed. This invention, through a unique formulation design, integrates multiple effects such as promoting blood circulation and removing blood stasis, dispelling wind and cold, relieving muscle tension and clearing meridians, and clearing heat and drying dampness. Combined with a refined pulverization process, it significantly improves the dissolution rate and transdermal absorption efficiency of the drugs. During use, a hot compress applied via steam allows the medicinal properties to directly reach the affected area, effectively relieving pain and discomfort in the neck, shoulders, waist, legs, and joints. This invention's product has a scientific formulation, advanced technology, is convenient to use, and highly safe, possessing broad market application prospects.

The invention belongs to the technical field of ecological water, mainly relates to ecological water for removing fruit peculiar smell, and particularly relates to ecological water for removing fruit peculiar smell and a preparation method thereof. Neotame and glucose modified cortex phellodendri are matched with tupistra chinensis, pogostemon cablin, liquorice and clove to be decocted into a traditional Chinese medicine decoction. According to the invention, lactobacillus plantarum ATCC 8014 and bacillus subtilis ATCC 6633 are used for fermentation. The antibacterial activity of the ecological water is improved, and the bitter taste of the cortex phellodendri is effectively removed due to the synergism of the two sweetening agents, namely the neotame and the glucose. The bacillus subtilis HZ-72 antagonistic bacteria used in the invention can enhance the capability of inhibiting pathogenic bacteria. Syzygium aromaticum has antibacterial activity, pogostemon cablin has an antiviral effect, and the syzygium aromaticum and the pogostemon cablin cooperate to enhance the antibacterial The ecological water prepared by the invention can remove peculiar smell and preserve freshness, and has a great development prospect in the field of fruit preservation.

The present application relates to the technical field of pesticides, in particular to a kind of pesticide composition, preparation, use and method, the pesticide composition includes the active ingredient A and active ingredient B with mass ratio of 1: (10-50), the active ingredient A is p-chlorophenoxyacetic acid or its agronomically acceptable salt, the active ingredient B is ethylene.The present application is by p-chlorophenoxyacetic acid (or its salt) and ethylene is compounded according to specific proportion with specific application concentration is applied, reaches the effect of controlling vigorous, inhibiting ear germination and increasing yield, alleviates the negative influence of growth inhibition to root system and young ear development caused by ethylene as the vigorous controller is used and the side effect of early decline and yield reduction caused by as ear germination inhibitor is used;Meanwhile, the pesticide preparation provided by the present application is soluble concentrate, and has high efficacy, strong penetration, convenient use, good safety, and the active ingredient is not easy to decompose, and the physical and chemical properties are stable.

This invention relates to the fields of pesticide formulations and pesticide pest control, specifically to a composite nano-slow-release suspension of emamectin benzoate and chlorantraniliprole, its preparation, and application. The nano-slow-release suspension comprises emamectin benzoate, chlorantraniliprole, a nanocarrier, a wetting agent, a dispersant, a synergist, a thickener, an antifoaming agent, an antifreeze, a preservative, and water. The nanocarrier is an NX-CMCS & MOF composite nanocarrier. Spraying this composite nano-pesticide onto crops improves the adhesion and penetration of the pesticide on leaves, enhances its resistance to rain washout, and effectively kills major crop pests such as bollworms, diamondback moths, cowpea thrips, and rice planthoppers. Compared with traditional pesticide formulations, it has a significant effect of reducing dosage and increasing efficacy, and has broad application prospects in the field of agricultural pest control and promoting green agriculture.

This utility model discloses a compound probiotic raw material mixing device, including a mixing tank. A feed pipe is fixedly installed on the mixing tank, and a discharge pipe is fixedly connected to the bottom of the mixing tank. An electromagnetic valve is fixedly installed on the discharge pipe. An installation ring is rotatably arranged inside the mixing tank. Two sets of connecting rods are fixedly installed on the circumference of the installation ring. Each set of connecting rods is fixedly connected to a vertical rod. An arc-shaped scraper is installed on one side of each vertical rod, and one side of the arc-shaped scraper is in contact with the inner wall of the mixing tank. An installation plate is fixedly connected to the upper end of each vertical rod. In this utility model, the arc-shaped scraper scrapes off the raw material adhering to the inner wall of the mixing tank. The stirring rod and the auger blade work together to stir and mix the raw material, improving the uniformity of the mixture and ensuring a balanced distribution of probiotics, thereby improving the overall quality and efficacy of the product.

This invention belongs to the field of agricultural herbicides and provides a photosynthetic inhibitor herbicidal composition comprising 5-aminolevulinic acid, malondialdehyde, and a herbicidal active ingredient. The herbicidal active ingredient is selected from one or a combination of several herbicides selected from acetolactate synthase inhibitors, photosynthetic system II inhibitors, or protoporphyrinogen oxidase (PPO) inhibitors. This invention utilizes the synergistic effect of 5-aminolevulinic acid, malondialdehyde, and a specific type of herbicidal active ingredient to effectively enhance the efficacy of the herbicidal active ingredient, enabling rapid and thorough weed control.

The present application relates to the technical field of traditional Chinese medicine, in particular to a preparation method of a tea-substitute formula for treating insomnia in young and middle-aged people, which comprises the following steps: crushing fried jujube seeds, cleaning and draining dried yam, dried red mulberry and mixing them, mixing and stirring the plant lactobacillus powder and the medicinal materials, constant temperature fermentation and low temperature drying after sealing, coarse grinding after drying, mixing with sweet hibiscus and sweet marigold to obtain the tea-substitute formula. The tea-substitute formula for treating insomnia in young and middle-aged people and the preparation method thereof mainly use fried jujube seeds to nourish the heart and calm the nerves, yam to calm the heart and calm the nerves, and fuling to invigorate the spleen and calm the heart as auxiliary, and combine dried red mulberry to nourish yin and tonify blood, sweet hibiscus to relieve depression and calm the nerves, and sweet marigold to harmonize the taste, so as to regulate the balance of neurotransmitters from multiple targets, regulate sleep as a whole, and use the enzymes produced by microorganisms to destroy the cell wall of traditional Chinese medicine, so as to effectively improve the dissolution rate and biological conversion rate of sleep-aiding effective components such as jujube saponin and lily alkaloids.

The present application relates to the technical field of air pipe aluminum skin processing, in particular to a mobile air pipe external thermal insulation aluminum skin folding tool, which comprises two "U"-shaped mounting racks, a lifting drive shaft is rotatably mounted on one side of each mounting rack opposite to each other, an "L"-shaped right-angle plate is liftingly mounted on the bottom of the lifting drive shaft, and a "U"-shaped folding steel plate is rotatably arranged on the bottom of the right-angle plate. The present application can position the aluminum skin through the setting of the folding ruler and the positioning block, can make the folding of the aluminum skin accurate in size, can effectively and accurately position the aluminum skin through the folding ruler, can obtain the aluminum skin more suitable for actual application according to the different requirements of the aluminum skin at different construction sites, can avoid the situation that the aluminum skin is too large or too small, and need not secondary processing, thereby greatly improving the installation efficiency of the air pipe external thermal insulation aluminum skin.

This invention provides a mulberry leaf and wolfberry composition, comprising aqueous extracts of wolfberry, mulberry leaves, astragalus, yam, kudzu root, and green tea. This invention also provides oral preparations and food products containing this composition. Furthermore, this invention provides the application of the composition or oral preparation in the preparation of health foods that help maintain healthy blood sugar levels and hypoglycemic drugs. The composition provided by this invention has the effect of lowering blood sugar, and the selected raw materials are highly safe, have few toxic side effects, and are widely available, possessing significant market value and development prospects.

Therapeutic combinations of immunoconjugates that bind to FOLR1 (e.g., IMGN853) with anti-VEGF agents (e.g., bevacizumab), a platinum-based agent, and / or doxorubicin are provided. Methods of administering the combinations to treat cancers, e.g., ovarian cancers, with greater clinical efficacy and / or decreased toxicity are also provided.

Therapeutic combinations of immunoconjugates that bind to FOLR1 (e.g., IMGN853) with anti-VEGF agents (e.g., bevacizumab), a platinum-based agent, and / or doxorubicin are provided. Methods of administering the combinations to treat cancers, e.g., ovarian cancers, with greater clinical efficacy and / or decreased toxicity are also provided.

The invention discloses composite hydrogel containing azelaic acid and a preparation method of the composite hydrogel, and belongs to the technical field of skin medicines.The azelaic acid is loaded and free azelaic acid is fixed through a layered structure of Ca / LDH powder, and then polymerization modification is conducted through dodecyl methacrylate, so that the composite hydrogel can be firmly smeared on the skin and is prevented from being scoured by sweat, and the skin care effect is good. Moreover, the Ca / LDH powder has an ion exchange characteristic between layers, so that a slow release effect on azelaic acid can be achieved; encapsulated menthol exists in the composite hydrogel containing azelaic acid, the encapsulated menthol is used for clathrating menthol through the clathration of a chitosan / cyclodextrin encapsulation carrier, and after clathration of the chitosan / cyclodextrin encapsulation carrier, a compact crystal structure of the carrier and the cavity clathration of cyclodextrin form a double barrier, so that the composite hydrogel containing azelaic acid has a good barrier effect. Contact between menthol and outside air and temperature is isolated, and volatilization loss of menthol is greatly reduced.

The invention relates to the technical field of cosmetic preparations, and discloses a composition containing succinyl glycan and application of the composition to regulation and control of the repetition distance of a liquid crystal lamellar phase, the composition comprises a liquid crystal component and an effective amount of succinyl glycan, wherein the stratified phase repetition distance of liquid crystals in the composition can be effectively adjusted by adding the succinyl glycan, and the thermal stability of the composition is improved; small-angle X-ray scattering (SAXS) proves that the addition of the succinyl glycan enables the repetition distance of the lamellar phase of the liquid crystal to generate a measurable change of 6.2% to 19.4%; the invention provides a novel method for accurately regulating and controlling the liquid crystal structure of the cosmetic from the nanoscale, and the obtained composition has better stability, moisture retention and skin feeling in use.

The invention discloses a compound polysaccharide preparation for treating diabetes and application thereof, and belongs to the technical field of biomedicine. The compound polysaccharide preparation is composed of compound polysaccharide A and compound polysaccharide B according to the mass ratio of 1: 1. The compound polysaccharide A is prepared from abelmoschus esculentus and chlorella through alkaline ultrasonic extraction and 10-100kDa ultrafiltration classification; the compound polysaccharide B is prepared by performing enzymolysis and hot water extraction on grifola frondosa and sarcodon aspratus. Experiments prove that the preparation can significantly improve insulin secretion and glucose uptake ability of islet cells, effectively reduce fasting blood-glucose of type 2 diabetes model mice and synchronously improve triglyceride and total cholesterol levels through strong synergistic interaction among the components. The preparation disclosed by the invention is natural in source, safe and efficient, so that a new choice is provided for medicine development of type 2 diabetes mellitus.

This invention discloses a chitosan-Chlamydomonas reinhardtii protein composite carrier, its preparation method, and its application. The composite carrier has a triple network structure, comprising: a three-dimensional network backbone formed by cross-linking chitosan and sodium tripolyphosphate, constituting the first network; a functional enhancing phase, including Chlamydomonas reinhardtii protein, which is embedded and anchored in the three-dimensional network backbone through a first physical interaction, constituting the second network, thereby forming a chitosan-Chlamydomonas reinhardtii protein complex with an interpenetrating network structure; and a structure-directing agent, including a hydrophobic active substance, which self-assembles and embeds into the hydrophobic microregions of the chitosan-Chlamydomonas reinhardtii protein complex through a second physical interaction, constituting the third network. The composite carrier provided by this invention is prepared using electrospinning technology, achieving high loading capacity and high encapsulation efficiency, constructing a multi-layered antioxidant defense network, and can serve as a highly efficient and stable multifunctional carrier for the preparation of functional food delivery materials.

A respiratory therapy system configured to provide respiratory therapy to a patient breathing in successive breathing cycles including an inspiration phase and an expiration phase, the system comprising: a pressure generator configured to supply a flow of pressurised air, the pressure generator configured to couple with a patient interface via an air circuit to deliver the pressurised air from the pressure generator to the patient; at least one sensor configured to provide one or more signals indicative of a pressure and a flow rate of the pressurised air flow; and a controller including a processor configured to: repeatedly detect values of instantaneous pressure and values of instantaneous flow rate from the one or more signals from the at least one sensor; repeatedly calculate instantaneous conductance values based on the values of instantaneous pressure and values of instantaneous flow rate; and monitor changes in the instantaneous conductance values over time to detect an occurrence of a respiratory event within the system.

The application discloses a kind of Fe3O4@SiO2@PDA-PVP magnetic nano adsorption material and preparation method and application thereof, and magnetic nano adsorption material includes silica coated Fe3O4 Nanoparticle, polydopamine and polyvinylpyrrolidone, in preparation process, Fe3O4 Nanoparticle is synthesized using solvothermal method first, then Fe3O4 Nanoparticle is dispersed into ethanol aqueous solution and tetraethyl orthosilicate and ammonia are added, Fe3O4@SiO2 Microsphere is obtained by reaction, then Fe3O4@SiO2 Microsphere is dispersed in buffer solution, then hydrochloric acid dopamine is added, Fe3O4@SiO2@PDA Nanoparticle is obtained after reaction, finally Fe3O4@SiO2@PDA Nanoparticle is dispersed in polyvinylpyrrolidone aqueous solution to obtain Fe3O4@SiO2@PDA-PVP.The application uses the above-mentioned Fe3O4@SiO2@PDA-PVP magnetic nano adsorption material and preparation method and application thereof, using matrix solid phase dispersion method, through the way of grinding of magnetic nano adsorption material and traditional Chinese medicine material, polyphenol extraction is carried out, the use amount of organic solvent is greatly reduced, environmental protection is good, can improve the extraction of polyphenol of traditional Chinese medicine material, and the extracted polyphenol also has higher efficacy.

The invention discloses an anti-tumor traditional Chinese medicine compound capable of removing three flavors. The anti-tumor traditional Chinese medicine compound is prepared from radix puerariae, radix scutellariae, rhizoma coptidis, cortex phellodendri, rhizoma atractylodis, radix angelicae sinensis, radix aucklandiae, radix pulsatillae, herba hedyotidis diffusae, rhizoma atractylodis macrocephalae and raw liquorice Compared with the original formula of compound radix puerariae decoction, the three-component-removing anti-tumor traditional Chinese medicine compound has the advantages that the three traditional Chinese medicines of gentiana macrophylla, rhizoma alismatis and betel nut which do not have the effects of clearing away heat and toxic materials and tonifying spleen and do not enter lung meridians are removed, the three-component-removing anti-tumor traditional Chinese medicine compound is obtained, and research finds that the formula still has the anti-colorectal cancer efficacy, the anti-breast cancer efficacy is increased, and the anti-tumor effect is good. Compared with the original formula of the compound radix puerariae decoction, the compound radix puerariae decoction has higher safety.

Improved anti-CD154 antibodies are provided herein which have improved therapeutic potency, in vivo half-life and ablated FcR binding and / or complement binding / activation. The use of these antibodies for inducing tolerance and treating immune diseases including autoimmunity, inflammation, transplant recipients, fibrosis and allergic disorders is disclosed herein.

This utility model discloses a microbial agent addition device for microbial fertilizer production, relating to the field of microbial fertilizer production technology. The device includes a chassis, a support plate on the upper side of the chassis, an inlet hopper on the upper side of the support plate, and a discharge hopper fixedly mounted on the lower surface of the inlet hopper. A discharge pipe is located on the lower side of the discharge hopper. A support plate is fixedly mounted on the upper side of the inner wall of the inlet hopper, and a motor is fixedly mounted on the upper surface of the support plate. The output end of the motor passes through the support plate and is fixedly mounted on a rotating column. A ring-shaped stirring column is fixedly mounted on the outer surface of the rotating column. The microbial agent addition device provided by this utility model prevents the microbial agent from settling and stratifying due to sedimentation, ensuring the activity and quality of the microbial agent and improving the efficacy of the microbial fertilizer. Simultaneously, the design of the positioning block, latch, and positioning slot allows for flexible adjustment of the discharge pipe angle, adapting to different production needs and enhancing the device's applicability and production convenience.

The application belongs to the technical field of medicine, and particularly relates to a composition for alleviating and repairing testicular damage caused by heat stress and application thereof. The composition for alleviating and repairing testicular damage caused by heat stress comprises the following raw materials: lycopene inclusion compound, ginsenoside Re, modified chitosan nanoparticles and a solvent. The amount of the modified chitosan nanoparticles is 10-15 wt% of the ginsenoside Re. The application innovatively designs a combination formula with lycopene and ginsenoside Re as the core. Both of the two main effective components in the formula are natural plant or traditional Chinese medicine extract, which effectively avoids the conflict between the medicinal properties of traditional Chinese medicines and has good biological safety. The composition can significantly repair the testicular damage caused by heat stress and accelerate the recovery after heat stress damage.

The application discloses a kind of portable underwater hot cutting equipment and method, including power supply device, base, shell, connector, ignition unit, nozzle and waterproof cover, the base is connected with shell and constitutes integrated structure, the connector is located inside base and is connected with external power supply device;The ignition assembly in the ignition unit, the diameter of first propellant and second propellant is sequentially increased setting, the first propellant is by gas-making agent, high-heat agent is added binder and is pressed into block by oil press and is constituted, the second propellant is by is by gas-making agent, high-heat agent, abrasive is added binder and is pressed into block by oil press and is constituted;The ignition assembly is connected with connector and is conducted, the nozzle is respectively connected with ignition unit and external communication, and high-temperature product generated by first propellant and second propellant is compressed by nozzle and becomes jet spray and is ejected by nozzle.This scheme is high in working efficiency and suitable for underwater, effectively overcome the problems existing in prior art.

This invention provides a monoclonal antibody specifically targeting fungal enolase 1, its preparation, and its application. The monoclonal antibody of this invention comprises the gene and amino acid sequences of the heavy chain variable region (VH) and the light chain variable region (VL). The monoclonal antibody or antibody fragment of this invention specifically targeting fungal enolase 1 can bind with high affinity to the fungal Eno1 protein and also bind to fungal cells, thereby inhibiting fungal adhesion, infection, and invasion of host cells. The monoclonal antibody provided by this invention has the characteristics of high specificity and good efficacy. When used alone, it can significantly treat invasive fungal infections. When used in combination with existing antifungal small molecule compound drugs, it can significantly enhance the efficacy of the small molecule compound drugs, achieving better therapeutic effects.

The application belongs to the field of treating blood vessel-bone coupling imbalance diseases in traditional Chinese medicine, and particularly relates to a composition for treating blood vessel-bone coupling imbalance diseases, a pharmaceutical preparation and application. Geniposide alone or in combination with crocin I can effectively reduce endothelial cell damage under pathological stimulation conditions, reduce the level of cell apoptosis and the degree of oxidative stress, improve the vascular endothelial function state, and can also significantly inhibit osteoclast differentiation, reduce the number of mature osteoclasts, and reduce bone resorption activity, thereby being conducive to restoring the dynamic balance between bone formation and bone resorption.