1820 results about "Royal jelly" patented technology

The invention discloses health food which consists of bee pollen, lyophilized royal jelly, bee glue and honey. Animal function test and human feeding trials testify that the health food has the health care functions of immunity strengthening and oxidation resistance.

The invention discloses a method of establishing liquid chromatography-mass spectrometry (LC-MS) analysis of a royal jelly sensitized protein. The method comprises the following steps: carrying out electrophoresis analysis on royal jelly proteins, preprocessing the sensitized protein bands, analyzing sensitized protein bands by LC-MS, screening the specific peptide fragments of sensitized proteins; extracting proteins from a royal jelly sample, digesting the proteins by enzymes, and quantitatively measuring the sensitized proteins by LC-MS / MS. The provided sensitized protein quantitative method has the advantages of high specificity and sensitivity, good repeatability, high accuracy, and wide linear range, and is capable of precisely and quantitatively analyzing a sensitized protein in a sample.

The present invention relates to a health-care food capable of regulating blood sugar and blood fat for preventing and curing diabetes. Its main component contains propolis, royal jelly, mulberry leaf and pueraria root, and its dosage form includes capsule preparation, tablet preparation, granule preparation and oral liquor, its optimized dosage form is soft capsule preparation. Besides, said invention also has the action of raising immunoregulatory compentence of human body. Said invention also provides its preparation method and its characteristics.

The invention belongs to the technical field of health care food, and particularly relates to a compound sea cucumber glycopeptide oral liquid. The oral liquid is characterized in that the sea cucumber is used as a raw material to extract glycopeptide liquid, and the glycopeptide liquid is added with royal jelly and traditional Chinese medicine extracting solution to obtain the oral liquid. The oral liquid comprises the following components by weight percentage: 50 to 70 percent of sea cucumber glycopeptide, 5 to 20 percent of royal jelly and 10 to 30 percent of traditional Chinese medicine extracting solution; and the components are subjected to mixing, homogenizing, sealing, packaging and sterilization to obtain the oral liquid. In the invention, the sea cucumber glycopeptide and the components having the efficacies of preventing and resisting cancer and prolonging life span are adopted, which has mutually coordinated and strengthened actions, and the natural materials can jointly make people healthy and long-lived; if being taken for a long period, the oral liquid can nourish and strengthen body, improve cell activity and delay aging; therefore, the oral liquid is new generation cancer resisting and life prolonging health care food with highly efficient immunologic function.

The invention relates to a detection method for simultaneously measuring the residue of tetracyclines (TCs) drugs in royal jelly, in particular to a detection method for simultaneously measuring the residue of 10 veterinary drugs including oxytetracycline, tetracycline, demethylchlortetracycline, chlorotetracycline, doxycycline, 4- epioxytetracycline, 4-epitetracycline, 4-epichlorotetracycline, minocycline and methacycline. The method comprises the following steps: precipitating protein by methanol; then, adjusting the pH value; further carrying out multi-stage purification; and simply and simultaneously measuring the residue of the TCs drugs by the liquid chromatography-mass spectrometry / mass spectrometer (LC-MS / MS). By carrying out the pre-treatment for one time, the invention can measure the residue of up to 10 TCs drugs in the royal jelly, wherein, the lower limits of detection (LLD) of the five TC antibiotics including oxytetracycline, tetracycline, demethylchlortetracycline, chlorotetracycline and doxycycline are 2.0 mug / kg; while the LLDs of the other veterinary drugs including 4- epioxytetracycline, 4-epitetracycline, 4-epichlorotetracycline, minocycline and methacycline are 10.0 mug / kg.

A capsule and an oral liquid prepared from edible flower of plant or extract of the flower belong to the technology field of food and health food. The capsule and the oral liquid contain 5 to 98% of flower or flower extract, and 2 to 95% of adjuvants. The flower is selected from Rosa rugosa, Camellia japomica, lily, Osmanthus Fragrans, Flos Rosae Chinensis, Lonicera japonica Thunb, Flos Chrysanthemi, Rhododendron, Sophora davidii, bombax ceiba, jasmine, Flos Mume, Diranthus chinensis, lotus, forget-me-not, Flos Sophorae, Lavandula angustifolia Mill., snow lotus, Flos Gomphrenae, Flos Hibisci, Flos Celosiae Cristatae, Flos Puerariae, Fructus Auranti, Gardenia jasminoides, Herba Taraxaci, orchid, Flos caryophyni, Camellia, Flos rosae multiflora, Aglaia flower, Herba Menthae Spicatae flower, Leonurus Artemisia flower, Iris japonica Thunb., loquat flower, Flos Magnoliae, Flos Citri Sarcodactylis, Michelia figo, Juncus effusus Linn., pine pollen, poney, etc. The flower extract is extract of the flowers, and the adjuvants are selected from citric acid, sucrose powder, Mel, Aspartame, xylitol, dextrin, starch, vitamin C, and royal jelly. The capsule and the oral liquid have the advantages of convenient administration, high nutrition and health protection values, good taste, etc.

The invention belongs to the technical field of health-care food, and relates to compound combined rape pollen chewable tablets and a preparation method thereof. The preparation method comprises the following steps of: crushing and screening a mixture of rape pollen, soybean lecithin, Chinese angelica extract, royal jelly freeze-dried powder, tea polyphenol, vitamin, soft sugar and microcrystalline cellulose, preparing the mixture into a soft material, then performing granulation and drying, performing granulation again to form granules, finally mixing the granules and magnesium stearate, pressing the granules and the magnesium stearate into tablets of different forms through a tablet press, and performing damp-proof packing. The soybean lecithin, the bee pollen, the Chinese angelica extract, the royal jelly freeze-dried powder and the like have complementary and additive effects; the chewable tablets can be directly chewed, are convenient for digestion and absorption, and have good taste; and the chewable tablets have unique effects of improving sleeping and removing chloasma at the same time of increasing multiple nutritional components, active enzymes and trace elements for the human body.

A health-care food for regulating blood sugar and blood fat and improving metabolism function contains proportionally the flour of oats or buckwheat, soybean powder or soybean protein, oligoisomaltose or edible fibre, spirulina, konjak starch, pueraria root, chromium nicotinate or CrCl3, ginseng, melissa powder, ganoderma or its spore powder, propolis powder of freeze-dried royal jelly powder, yam and xylitol.

The invention discloses a specific antibody of major royal jelly protein MRJP1 and a preparation method thereof and Elisa quantitative detection thereof. First, homology analysis is performed to amino acid sequences of proteins of all members of the Apismellifera major royal jelly protein MRJPs family (MRJP1-MRJP9) to select a specific polypeptide amino acid sequence unlike other MRJPs family members in MRJP1. The related specific polypeptide is synthesized by using a chemical method, and is used as an antigen to immunize New Zealand white rabbits; taking serum, and performing Elisa assay obtaining polyclonal antibody R2 with a relatively high titer, then purifying the antibody by using an affinity column prepared from the synthesized MRJP1 polypeptide. The titer of antibody R2 is detected via Elisa assay by using MRJP1 as the antigen, and the titer of the antibody is greater than 1:20000. The present invention provides a very reliable new rapid detection method for the qualitative and quantitative detection of MRJP1 in royal jelly, and also provides a very reliable technical means for quality control, freshness detection, and identification of genuine products of royal jelly and honey products for bee product quality supervision departments and processing and trading enterprises.

The invention relates to an integrated device for beewax cutting and jelly collecting for obtaining royal jelly. The integrated device comprises an air compressor, a gripping switch, a gun arraying pipe, a stander, a queen cell seat and a scraper frame, wherein the an air compressor is connected with the gripping switch, the exit end of the gripping switch is connected with the gun arraying pipe, nozzles are mounted on the gun arraying pipe, the queen cell seat is mounted on the stander, jelly producing strips are clamped in the queen cell seat, a jelly collecting disc is placed below the jelly producing strips, a guide rail is mounted on the queen cell seat and is connected with a slide block, the scraper frame is mounted on the slide block, a scraper is mounted on the scraper frame, and a rocking handle is connected with the slide block through a crank connecting rod. When the integrated device for the beewax cutting and the jelly collecting for obtaining the royal jelly is used, the slide block and the scrapper are driven by the rocking handle to do reciprocated cutting movement, the oil-free air compressor sequentially acquires clean air through an oil filter and a water steam filter by a hose, the self-coagulated royal jelly is blown out by clean air flow, and the royal jelly and larvae are separated by a stainless steel gauze. The integrated device for the beewax cutting and the jelly collecting for obtaining the royal jelly has the characteristics that the operation is simple and convenient, the labor intensity of users is lowered, and the working efficiency is substantially improved.

The present invention relates to a health-care food for improving sleep. Said health-care food is made up by using high-quality royal jelly and adding natural plant extract through a certain preparation process, in which the natural plant extract includes the spring jujube kernel extract, acanthopanax root extract and ganoderma extract. Said invention can be made into hard capsule, soft capsule, tablet, granules and oral liquor which have good effect for improving sleep and raising sleeping quality.

The invention discloses a royal jelly taking method and device. The royal jelly taking method comprises the steps that a filter screen is arranged on jelly strips, the royal jelly in the jelly stripsand larvae are downward fed onto the filter screen, and the filer screen is utilized to separate the royal jelly and the larvae. The royal jelly taking device comprises a rack and the royal jelly strips, wherein the royal jelly strips include a plurality of royal tables, each royal table comprises a columnar jelly taking head, a piston is arranged in the jelly taking head and is connected with a push rod, one bottom surface opening of the jelly taking head serves as an outlet, the push rod extends out of the jelly taking head from the other bottom surface of the jelly taking head, and the jelly taking head outlets are downwards formed and cover the filter screen. The royal jelly taking device also comprises a jelly taking head fixing mechanism and a collection driving mechanism, wherein the collection driving mechanism is used for driving the pistons to move back and forth in the jelly taking heads. The royal jelly taking device can achieve automatic royal jelly collection, can also achieve royal jelly and larva separation, makes larvae not hurt in the royal jelly taking process and improves the quality of taken royal jelly and the royal jelly taking efficiency.

The invention discloses guava fermented red bean milk with a cosmetic effect. The guava fermented red bean milk is prepared by the following raw materials: by weight, 4 to 8 parts of beautifying Chinese medicinal solutions, 3 to 4 parts of white granulated sugar, 3 to 5 parts of freeze-dried powder of royal jelly, 4 to 6 parts of red beans, 1 to 2 parts of purple potatoes, 0.1 to 0.2 part of black sesames, 0.4 to 0.5 part of oats, 1 to 2 parts of peas, 0.1 to 0.2 part of Chinese yams, 0.5 to 0.6 part of roots of kudzu vine, 1 to 2 parts of red glutinous rice, 8 to 10 parts of guavas, 75 to 85 parts of fresh milk, and an appropriate amount of yoghourt zymocyte. The guava fermented red bean milk with a cosmetic effect has special fragrance of baked composite red bean dregs, and has a cosmetic effect because of cooperation of various Chinese medicines.

The invention discloses anti-acne cosmetic containing Taiwan hibiscus taiwanensis extract. The Taiwan hibiscus taiwanensis is taken as a main functional component and is matched with such natural extracts having anti-acne functions as a royal jelly extract, a guava leaf extract, an olive extract and a honeysuckle extract; no chemical bactericides, hormones, astringents, anti-inflammatory agents, preservatives or the like are added; and the anti-acne cosmetic has good deoiling and acne-removing effects. The anti-acne cosmetic which is safe and mild and has long-lasting and comprehensive functions is developed, aiming at the defects of the anti-acne cosmetics available on the market at present and the market demands; and the anti-acne cosmetic is suitable for all people.

The invention provides a method for distinguishing Chinese honeybee honey from apis mellifera honey based on major royal jelly protein ingredients. By means of a biological method and the difference between Chinese honeybee honey and apis mellifera honey in protein, different protein bands appear by conducting protein electrophoresis on a honey sample after the honey sample processed, protein categories are determined by conducting mass spectrometry on the different protein bands, and then the two kinds of honey from different bee species are identified. The problems that Chinese honeybee honey and apis mellifera honey available in market are hard to distinguish, and apis mellifera honey pretends to be Chinese honeybee honey or is mixed in Chinese honeybee honey are solved, and the situation that low-price apis mellifera honey pretends to be high-price Chinese honeybee honey can be inhibited. The method is used for distinguishing Chinese honeybee honey from apis mellifera honey.

The invention relates to a nutrition food with oxidation resistance function and a preparation method thereof, belonging to the field of functional foods. The functional nutrition food is mainly prepared by medicine and food dual-purpose materials according to the following parts by weight: 1-5 of Shizhu panax, 1-5 of chrysanthemum, 3-9 of sessileflower acanthopanax barks, 3-9 of tuckahoe, 3-9 of niger seeds, 1-5 of peach kernels, 3-9 of bee pollen, 1-5 of white fungus, 1-5 of blackfungus, 1-5 of monkey's head mushrooms, 2-8 of mushrooms, 1-5 of grape pips, 0.5-1.5 of lycopene and 0.5-1.5 of royal jelly. Results of experiments on animal and human prove that the nutrition food has obvious oxidation resistance function and can also improve the immunization, thereby being suitable for the people needing oxidation resistance, but not suitable for children.

The invention discloses an Apis cerana royal jelly antibacterial peptide AccRoyalisin gene and an encoded polypeptide thereof and application thereof. The gene has a DNA sequence shown as SEQ ID No.4; and the encoded protein of the gene has an amino acid sequence shown as SEQ ID No.5. The antibacterial peptide gene can establish a high-expression genetic engineering strain by building an Escherichia coli expression vector, and performing producing and separating and purifying on a recombinant product through induction expression of the fermentation engineering. The recombinant product thereof has an obvious inhibiting effect on a plurality of gram positive bacteria, such as bacillus subtilis, staphylococcus aureus and micrococcus flavus and the like, can be used for preserving and refreshing foods, in particular for preventing food-born bacterial contamination, is harmless to human body and animals, can serve as a substitute of antibiotics and chemical preservatives and is also suitable for preventing and controlling bred animal bacterial diseases. The Apis cerana royal jelly antibacterial peptide AccRoyalisin gene and the encoded polypeptide thereof lay a foundation for the development, the massive industrial production and the application of the Royalisin.

The multivitamin nutrient includes vitamins and the mixture of American ginseng, ginseng, dendrobium stem, royal jelly, pollen and several other nutritive matters. It has reasonable composition, and can replenish the nutritive components essential for human body, regulate metabolism and other life activities, strengthen life vitality, raise immunity, raise the capacity of resisting fatigue, anoxia, radiation, oxidation and senility, and lower blood viscosity.

The invention relates to a method for simultaneously measuring residual quantities of lincomycin and macrolides in royal jelly by a liquid chromatography and a tandem mass spectrometer. Currently, the prior method can not achieve the goals of low detection cost and a detection limit less than 1 mu g / kg. The method comprises the steps of standard solution preparation, royal jelly sample treatment,standard curve making and royal jelly sample detection; in the step of royal jelly sample treatment, acetonitrile ammonia water with the volume concentration of 97% is used as the extracting solution, residues in a 50 ml glass centrifuge bottle after vacuum concentration are transferred by a phosphate buffer solution and mixed with ethyl acetate so as to carry out extraction; and finally, the detection sample solution is measured by a high performance liquid chromatograph and a ternary quadrupole tandem mass spectrometer to obtain the residual quantities of lincomycin and macrolides in royal jelly. The invention has the advantages of low detection cost and high detection efficiency, the detection limit reaches 0.2-0.9 mu g / kg, and the linearly related coefficient is 0.9914-0.9994.

The invention discloses a health care beverage that has effects of relieving alcoholism, protecting liver, invigorating spleen and nourishing stomach and a preparation method thereof. The health care beverage of the invention mainly consists of the following constituents based on proportions by weight: 2-8 portions of honey, 0.5-2 portions of royal jelly, 0.1-0.6 portion of bee glue and 4-12 portions of haw. The beverage of the invention can not only rapidly ease or reverse varied drunken symptoms of headache, dizziness, nausea, vomiting, inappetence, blurred vision, slow reaction, etc. but also supplement varied nutrients that are short in human body in time to improve human immunity and rapidly repair harm to the human body caused by alcohol. Besides, the beverage of the invention has unique flavor, pleasant sweetness and sourness but no toxicity or side effects, thereby being easily accepted by different groups of people.

The invention relates to the technical field of skin care products, in particular to eye essence containing a lactobacillus fermented lysate product and a preparation method of the essence. The eye essence comprises, by weight, the lactobacillus fermented lysate product, a tea extract, a pomegranate peel extract, caffeine, royal jelly polypeptide, oat beta-glucan, a buckwheat seed extract, ceramide, an emulsifier and a solvent. The eye essence is mild and safe and is easily coated and absorbed, the tea extract, the pomegranate peel extract and the caffeine are used as a main anti-aging and antioxidation frame of the eye essence, the energy of the skin cells is improved in combination with the lactobacillus fermented lysate product, and the absorption capacity of the skin is improved; meanwhile, royal jelly polypeptide, oat beta-glucan, the buckwheat seed extract and ceramide are used a nutrient frame, the nutrients and moisture are supplemented for the eye skin in time, and the effectsof the eye essence on anti-aging, wrinkle removal, antioxidation and nutrient supplement are achieved.

The invention discloses fragrant grass vagina cleaning liquid and a preparation process thereof, and relates to the fragrant grass vagina cleaning liquid for preventing and treating gynecological inflammation and the preparation process thereof. The fragrant grass vagina cleaning liquid is prepared by processing glossy privet fruit, angelica dahurica, Chinese ligusticum rhizome, mint, divaricate saposhnikovia root, ash bark, amur corktree bark, yerbadetajo herba ecliptae, baical skullcap root, gardenia, lightyellow sophora root, motherwort herb, white paeony root, heartleaf houttuynia herb, nutgrass galingale rhizome, common cnidium fruit, rhubarb, spreading hedyotis herb, honeysuckle flower, dandelion, weeping forsythiae, belvedere fruit, borneol, borax, alum, citric acid, royal jelly, sorbic acid, sodium bicarbonate, glycerol, ethyl cellulose, vitamin C, sodium salt, citric acid and sodium hydroxide serving as raw materials. A product does not have stimulus or dependency, is not influenced by much secretion, and can kill bacteria and microorganism pathogen in vagina, protect mucosal tissues in the vagina, improve the physiological function of female genital organs and prevent and treat diseases.

The invention aims to provide a piglet forage. The piglet forage comprises, by weight, 1-5 parts of fried wheat bran, 1-5 parts of fried soybean powder, 20-30 parts of millet, 1-5 parts of white sugar, 20-30 parts of fishmeal, 1-5 parts of bone meal, 1-5 parts of shell powder, 20-30 parts of silkworm chrysalis, 10-20 parts of Semen Aesculi, 10-20 parts of asparagus, 20-30 parts of mulberry, 1-5 parts of royal jelly, 20-30 parts of pumpkin, 20-30 parts of water chestnut, 10-20 parts of milk powder, 10-20 parts of Origanum vulgare, 10-20 parts of Humulus japonicas, 10-20 parts of Raphanus sativus L, 1-5 parts of dry ginger, 10-20 parts of seaweed meal and 1-5 parts of doederlein spikemoss herb. The forage contains trace elements beneficial for the growth absorption of piglets and forage raw materials for promoting the growth adjustment, so the generation and enrichment of organic trace elements in the piglets are realized, thereby the survival rate is increased, and the disease occurrence is reduced.

The invention provides a compound bee product preparation capable of enhancing the immunity, belonging to the technical field of health food. The compound bee product preparation comprises the components based on parts by weight of: 10-60 parts of bee pollen, 2-20 parts of bee glue, 2-20 parts of royal jelly, 2-15 parts of queen bee tire, 2-15 parts of bee pupa and 2-10 parts of American ginseng.The preparation method of the compound bee product preparation comprises the following steps of: treating, drying, smashing, preparing and mixing. The bee pollen, the bee glue, the royal jelly, the queen bee tire, the bee pupa and the American ginseng are treated, dried, smashed, prepared and mixed into various medical forms. The compound bee product preparation has the following beneficial effects of: being simple in preparation method, and having the effects of improving the immunity, reducing the blood fat, relaxing the bowels, protecting the liver, resisting the fatigue, improving the sleep, resisting the ageing and the like.

The invention provides queen bee wine and a brewing method thereof. The queen bee wine contains bees and over 50-degree distilled spirits, wherein the bees can be honeybees and preferably are drone pupae, and can also be bee products such as royal jelly; and the ratio of the bees and / or the bee products to the distilled spirits is 1:2-1:10, preferably 1:3-1:7. The queen bee wine brewed by the method of the invention has the advantages of pure chroma and good mouthfeel.

The invention provides a method for measuring the content of apis mellifera MRJP1 protein (major royal jelly protein 1) in honey by using liquid chromatography-tandem mass spectrometry. The method comprises the steps of selecting characteristic peptides, preparing a standard curve, pre-treating a sample, performing liquid chromatography separation, and detecting and quantifying tandem mass spectrometry. The method for detecting the content of apis mellifera MRJP1 in honey provided by the invention has the advantages of strong specificity, high sensitivity, good accuracy and precision, and is suitable for accurate quantification of apis mellifera MRJP1 in honey. Since the content of MRJP1 in honey is relatively constant, the method can be used for evaluating the authenticity of honey basedon the content and assisting in identifying whether honey is adulterated or not. In addition, apis cerana honey does not contain apis mellifera MRJP1 and thus can be used for identifying whether apismellifera is mixed in the apis cerana honey. The method is of great significance for maintaining the healthy development of the honey consumption industry and the rights and interests of honey consumers.

The invention discloses a method for breeding a high-quality mite-resistant bee species. The method is characterized by comprising the following steps of: (1) selecting breeding materials: screening a 'Jiangshan No.2' Italian bee with a high royal jelly yield, a French pure-bred Italian bee with excellent honey making performance and a healthy local Chinese bee species with excellent mite resistance for serving as an introduction object according to series indexes such as mite resistance, productivity, vitality and the like; (2) breeding a mite-resistant bee species: breeding a breeding male bee from Jiangshan No.2, breeding a Jiangshan No.2 virgin queen bee according to the requirements of bee biology and genetic breeding characteristic, and performing artificial fertilization hybridization with the bred breeding male bee to form a Jiangshan No.2 bee species with high production performance and disease resistance for serving as a male parent, wherein a pure-bred Italian bee with excellent honey making performance introduced from France serves as a female parent; and (3) checking and cutting a French Italian bee drone pupae every 7 days from breeding in spring till the end of breeding. The harm of bee mites to bee colonies can be avoided for beekeepers, the reproduction speed of the bee colonies is increased, and the yields and qualities of bee products are improved.

The invention relates to a preparation method of honey peanut kernel with strawberry flavor. The preparation method comprises the following steps: firstly, selecting high-quality peanut kernels and cleaning; secondly, preparing strawberry and honey soaking solution; thirdly, soaking the peanut kernels; and fourthly, drying, bagging and obtaining finished product. The peanut kernel prepared by thepreparation method not only keeps the mineral nutrient and dietary fiber of peanut kernel but also absorbs the nutritional ingredient of honey and bee milk, can be absorbed by a human body easily, and can achieve good health care function and aphrodisiac effect after being taken for a long time.

The invention provides ginseng royal jelly chewable tablets and a preparation method thereof. The preparation method comprises the following steps: after taking 100 parts by weight of royal jelly and adding 3 to 7 parts by weight of starch to mix, carrying out the steps of freeze drying and ball milling to obtain royal jelly lyophilized powder; after taking 100 parts by weight of ginseng and carrying out vacuum drying at a temperature of 80 DEG C, immediately cooling to 0 DEG C, then foregrinding to form ginseng coarse powder and carrying out the vibrating superfine grinding step to obtain ginseng micro powder with the particle size of 12 to 15mum; mixing the ginseng micro powder and 200 to 300 parts by weight of filler, 120 to 250 parts by weight of flavoring agent, 80 to 120 parts by weight of adhesive and 3 to 7 parts by weight of disintegrating agent, adding 70 percent of ethanol solution to pelletize and drying to obtain ginseng soft materials; and carrying out the step of mixing royal jelly dry powder and the ginseng soft materials and adding 5 parts by weight of magnesium stearate to carry out tableting to obtain the ginseng royal jelly chewable tablets. The invention solves the problems of serious ginseng loss, low yield, mixing nonuniformity and the like in the prior art.

The invention discloses an oil-control cosmetic composite, wherein the formula comprises the following components in percentage by weight: 0.01-10% of water-soluble zinc salt, 0.1-8% of oil-absorbing powder, 0.1-15% of royal jelly extract, 0.1-20% of natural Chinese herbal medicine extract, 0.32-47% of cosmetic base materials, and the residue of deionized water. In the invention, the composite can reduce the oil secretion, absorb skin oil, continuously control the secretion of the skin oil and have great tenderness; and proved by experiment, the composite has better capability of controlling active sebaceous glands in comparison with the market products, greatly reduces the secretion volume of the oil and is effective continuously.