164 results about "Tretinoin" patented technology

An improved method and preparation for the treatment of acne and hirsutism comprises topically applying an effective amount of a saw palmetto berry extract, and preferably one or more low irritability constituents that enhance penetration of the extract into hair follicle sebaceous glands. The low irritability penetration aid may be selected from the group consisting of adapalene, tretinoin, tretinoin gel microsponges, retinaldehyde, retinol, tazarotene, beta hydroxy acids (salicylic acid), azelaic acid, and alpha hydroxy acids (glycolic acid) as well as polyolprepolymer-2.

Topical aqueous compositions for the treatment of a skin disorder particularly acne. Topical aqueous composition comprising tretinoin and a hydrophilic cellulose derivative as a gelling agent, wherein the composition has a pH of about 4 to about 6.5 and viscosity of less than about 20,000 cP or provided. The composition also relates to the topical administration of tretinoin in combination with an antibiotic.

The invention provides a method for transforming 11-cis-tretinoin into all-trans tretinoin, which is characterized by using a palladium nitrate composite catalyst. The invention also provides a method for synthesizing the all-trans tretinoin, which comprises the following steps of: using compounds (II) and (III) as raw materials to perform WITTIG reaction under the action of alkali so as to obtain a mixture of all-trans retinoic acid ester and 11-cis-retinoic acid ester; performing hydrolysis and acidification to obtain a mixture of the all-trans tretinoin and an isomer 11-cis-tretinoin; and transforming the isomer to obtain the target product namely the all-trans tretinoin. The method can be finished by two steps and has the advantages of complete reaction, high yield, less isomer content in the finished product and low cost, and is suitable for industrial production.

In one embodiment, the present invention is a method of creating a fully-human blood-brain barrier (BBB) model, comprising the steps of (a) obtaining a mixture of neural cells and brain microvascular endothelial cells (BMECs), wherein the neural cells and BMECs that comprise the mixture were produced from the differentiation of human pluripotent stem cells (hPSCs); (b) purifying BMECs from the mixture of neural cells and BMECs of step (a); and (c) co-culturing the purified BMECs with a cell type selected from the group consisting of pericytes, astrocytes and differentiated neural progenitor cells (NPCs), wherein a blood brain barrier model is created.

The invention relates to compound gel containing clindamycin. The compound gels comprise effective dose of the clindamycin or medicinal salt or ester, Tretinoin and gel matrix. The invention is characterized in that the gel matrix is celluloses derivative, a preparation method as well as the detection and analysis methods of the gel are also related. The gel of the invention has the advantages of easy quality control, simple preparation technique and being suitable for industrial production.

The invention relates to a gel composition for treating acne, which comprises the following components in percentage by weight: 0.01 to 20 percent of at least of a retinoic acid active component, 0.01 to 20 percent of diphenylperoxyanhydride, 0.1 to 10 percent of at least one high polymer gel and 0.1 to 4 percent of antioxygen, wherein the antioxygen may be one or more of butylated hydroxytoluene (BHT), ethylenediaminetetraacetic acid-2 (EDTA-2), Na, butylated hydroxyanisole (BHA), vitamin E, vitamin E acetate and vitamin E nicotinate. The composite antioxygen used in the invention can effectively solve the chemical and physical stability problems of retinoic acid and diphenylperoxyanhydride composite preparation, and it is found that the antioxygen has good chemical and physical stabilizing effect on common gel systems, greatly improves the gel selection range, recues cost, simplifies operation steps and effectively controls product quality.

The invention provides a compound clobetasol propionate mixed micellar solution. Phosphatide and cholate are mainly utilized to prepare the mixed micellar solution which is used for packaging clobetasol propionate and tretinoin. The mixed micelle solution can be simply prepared, and the medicament stability can be guaranteed in the process of preparation. By preparing a mixed micelle system from the phosphatide and the cholate, the problem of medicament dissolution is solved. Compared with a common ointment, the mixed micelle solution has a higher retention volume on skins, and the quantity of the medicament on local skins and the therapeutic index can be increased. The mixed micelle solution can be further prepared into an ointment and a gel, and is mainly used for treating psoriasis vulgaris, dermatitis, eczema, etc.

This invention provides a cream for treating psoriasis and its preparation method. The cream is prepared by adding small dose of tretinoin into volatile oil of Rhizoma Zedoariae, packaging through modern pharmacy method, and making into oil in water compound cream with stearic acid, glyceryl monostearate, white vaseline, liquid paraffin, glycerol, triethanolamine, sodium lauryl sulfate, phenol ethyl ester, and distilled water. Compared with present technology, the inventive medicine has the advantages of high security, good therapeutic effect, no toxicity or adverse side effect, low recurrence rate, stable property, controllable quality, and low cost.

The invention discloses a traditional Chinese medicine composition for removing acne and an application thereof. The pharmaceutical composition comprises the following components: an extract product of Centella asiatica, an extract product of scutellaria roots, vitamin E, clove oil, an extract product of licorice, an extract product of flavescent sophora, hydrolyzed pearl, and borneol, and the materials and a proper amount of matrix are used for preparing a preparation for external use. The traditional Chinese medicine composition has efficacies for clearing heat and draining dampness, detoxifying, and dispersing the swelling; the composition has multiple efficacies for better inhibiting growth of Propionibacterium acnes without generation of drug resistance, resisting hyperplasia of scar, resisting chromatosis, resisting inflammation, easing pain, preserving moisture, adjusting balance of oil and fat, and the like; the product has obvious anti-acne effects, and can be used for thoroughly eradicating acne without recurrence after healing; the product does not have toxic and side-effects, and acne removal does not leave marks. Total effective rate of the traditional Chinese medicine composition for treating acne in four weeks is 100%, and acne of healed patients does not recur. After acne is treated, total effective rate for resisting chromatosis reaches 85.71%, the curative effects are better than the effects of Tretinoin cream, and obvious adverse reactions are not observed.

A composite lipid for treating and preventing pigmentation and photosenile dermatopathy is prepared from tretinoin, licoflavone, lecithin and surfactant through including the tretinoin and licoflavone in lecithin.

A medicine for treating psoriasis vulgaris contains clobetasol propionate and vitamin A acid. Its preparing process is also disclosed. Its advantages are high curativ effect, and low toxic by-effect.

The present invention relates to mixed esters of hyaluronic acid, wherein the hydroxyl groups are partially esterified with retinoic and butyric acids. These mixed esters are characterized by specific degrees of esterification and by a high ratio between the degree of substitution with butyric acid and retinoic acid. They exhibit a high anti-proliferative activity associated with activation of cell differentiation, with consequent clinical relevance in the treatment of hyper-proliferative pathologies and in particular of solid and systemic tumors.

The present invention relates to a compound medicine for external application for curing acne and its preparation method. Its composition contains the following two active components: (wt%) 0.01-2% of tretinoin and 0.25-5% of antimicrobial. Said compound medicine can be made into liniment or anhydrous ointment, and has the following therapeutic functions, dissolving keratotic plug, regulating keratosis, resisting microbe, relieving inflammation and reducing secondary factor of sebaceous secretion, so that it can obtain obvious therapeutic effect.

Compositions and methods for treatment of skin conditions, such as age spots, liver spots, photodamaged skin, skin folds, diminished hair growth, non-infectious cellulite and “orange skin”, or for repairing damaged DNA in a skin cell, utilize a formulation including about 0.01-1 part by weight tretinoin, and about 1-45 parts by weight dimethylfsulfoxide. Compositions may include about 5-40 parts by weight urea, and about 45-90 parts by weight carrier.

The invention relates to a stem cell culture medium which comprises a basic culture medium and an additive. The additive contains 1-200 [mu]g/mL of recombinant transferring, 1-300 [mu]g/mL of recombinant albumin, 0.1-200 ng/mL of recombinant cell factors, 10-300 [mu]g/mL of free fatty acids, 0.1-10 mg/mL of a protease inhibitor, 20-300 [mu]g/mL of vitamins, 0.5-10 mg/Ml of zinc sulfate, 0.01-1 mmol/L of tretinoin, 10-60 nmol/L of sodium selenite and 5-100 [mu]g/mL of niacinamide. The invention also discloses a stem cell culture method which carries out three-dimensional culture on stem cells with a serum-free stem cell culture medium. According to the culture medium and the culture method provided by the invention, the applicability of the culture medium is expanded, and meanwhile, a stable growing environment is provided for stem cells, so that the stem cell culture efficiency is improved obviously and the using cost of the culture medium is lowered.

The invention relates to an emulsifiable paste for treating acne, which comprises the following raw materials by weight: 70-150 parts of ketoconazole, 70-150 parts of lincomycin, 1200-2400 parts of metronidazole, 300-1200 parts of moroxydine hydrochloride, 35-90 parts of viaminate, 5-20 parts of tretinoin, 200-350 parts of vitamin E, 80-200 parts of vitamin B6, 50-100 parts of lidocaine, 600-2000 parts of aloe extract product, 1000-2000 parts of coconut meat powder and 100-800 parts of collagen powder with molecular weight lower than 2KD. The emulsifiable paste has the advantages of antibacterial function, antifungal function and anti-virus function, can promote epidermal cell differentiation and shedding, epidermal cell proliferation and differentiation can be adjusted, cornification is avoided, sebum secretion is adjusted, the emulsifiable paste has the effects of relieving pain, relieving itching, mitigating pockmark and whitening skin, and can help luster recovery for skin.

The invention discloses a culture fluid that promotes the generation of a lipid structure of tissue engineered skin. A basic culture fluid is added with hydrocortisone, epidermal growth factors, isoproterenol, insulin, transferrin, triiodothyronine, adenine, vitamin C, tretinoin, cholera toxin, L-serine, L-novain, palmic acid, linoleic acid, arachidonic acid, bovine pituitary extract, bovine serum albumin, calcium chloride, penicillin, streptomycin and fungizone B, etc. Tissue engineered skin with mature and completely differentiated horny layer and good lipid structure can be obtained by cultivating keratinocyte in the culture fluid of the invention, the culture fluid has strong stability, long shelf life of about 12 months, simple and convenient preparation method, and convenient product synthesis and mass production.

The present invention discloses a compound gel preparation-compound tretinoin gel preparation for curing acnes. It is made up by using carbomer, glycerine, propylene alcohol, Tween, triethanolamine, clindamycin phosphate, tretinoin, EDTA and distilled water as raw material through a certain preparation process. Said invention also provides the concrete steps of its preparation method.

The invention provides an animal lung bud organoid culture medium and culture method. The culture medium comprises a basic culture medium SAGM, sterile water and functional components, wherein the final concentration composition of the functional components in the organoid culture medium comprises: 0.5-2X of B27, 10-50 ng/ml of HGF, 2-20 ng/ml of BMP7, 20-200 ng/ml of EGF, 2-20 ng/ml of KGF, 100-400 ng/ml of FGF4, 1-20 [mu]M of SB216763, 10-100 nM of tretinoin, 20-200 ng/ml of Wnt-3A, 0.1-1 [mu]M of Prostaglandin E2, 0.5-2X of Insulin-Transferrin-Se, 5-20 mM of HEPES, 100 U/ml of penicillin, and 0.1 mg/ml of streptomycin. The culture medium of the invention is beneficial to the growth and function maintenance of lung bud organoids, and can culture lung tissues derived from mice and rats.

The invention relates to an acne-removing cream capable of rapidly removing facial acne without leaving marks on face. The acne-removing cream is prepared by adding suitable amounts of tretinoin, anchoic acid, erythromycin, boracic acid and oil soluble azone on a basis of octadecanol, glycerin monostearate, emulsifying agent, propylene glycol and glycerol propanetriol by an emulsification technology. Compared with the prior art, the invention has the advantages of quick effect, colorlessness, tastelessness, (3) no marks left after acne is removed and low manufacture cost.

The invention provides a special culture medium for lung cancer organoid and a culture method. The culture medium comprises a basic culture medium and a specific additive factor, wherein the specific addition factor comprises GSK429286A, Y27632, EGF, BMP4, Human FGF4, insulin-transferrin-selenium (Insulin-Transferrin-Selenium), B27, all-trans tretinoin acid (all-trans tretinoin acid), KGF, DAPT, GlutaMAX, R-Spondin-1, CHIR99021, 8-Br-cAMP, bovine serum albumin (BSA), and a phosphodiesterase (PDEs) inhibitor. According to the culture medium, rapid growth of the lung cancer organoid can be achieved, long-term stable culture can be achieved, formed tumor organoid cell spheres are regular in shape and uniform in size, and heterogeneity of tumor tissue of a patient can be well reserved in vitro.