11 results about "Tretinoin" patented technology

The invention provides efficient mild whitening cream and a preparation method thereof. The raw materials of the cream comprise five phases A and E, the phase C contains 0.1-3% of a mixed solution of isosorbide dimethyl ether and hydroxyl pinacolone retinoate, and the phase D contains 0.01-0.1% of L-carnitine. Wherein the hydroxyl pinacolone retinoate can be specifically combined with an RAR / RXR (Region Receptor / Receptor X Receptor), and the expression of an MITF (Microphthalmia-associated Transcription Factor) gene is reduced, so that the melanogenesis is inhibited; l-carnitine promotes fatty acid beta-oxidation and enhances ATP synthesis to indirectly regulate and control AMPK activity; aMPK enhances transcriptional activity of a tretinoin receptor through phosphorylation of the tretinoin receptor, so that the AMPK and hydroxyl pinacolone retinoate exert a synergistic effect, jointly enhance whitening activity, effectively improve the phenomena of color spots and dark skin and promote the skin color to be uniform, bright and white; meanwhile, the isosorbide dimethyl ether can promote the transdermal absorption of the hydroxyl pinacolone retinoate, the L-carnitine and the related active ingredients.

The present application belongs to the field of biomedicine, and relates to an inducer for inducing mesenchymal stem cells to differentiate into estradiol-secreting cells. The inducer for inducing mesenchymal stem cells to differentiate into estradiol-secreting cells is based on a human mesenchymal stem cell serum-free culture medium, and is composed of the following components in a mass concentration ratio: bone morphogenetic protein-4 20-60 mg / L, bone morphogenetic protein-7 20-60 mg / L, tretinoin 2-8 mg / L, resveratrol 2-8 mg / L, icariin 2-8 mg / L, benzamide 2-8 ug / L, chloroplatinic acid hexahydrate 2-8 ug / L, ethanolamine 2-8 ug / L, erythropoietin 2-10 ug / L, and vascular endothelial growth factor 2-10 ug / L. The inducer for inducing mesenchymal stem cells to differentiate into estradiol-secreting cells has high induction efficiency.

The invention provides compositions and methods for providing a cardioprotective effect in a subject. Specifically, the invention provides compositions and methods for treating cardiovascular ailments, for example, ischemia / reperfusion (I / R) injury, cardiac arrhythmias, oxidative stress, or cardiac failure by administering a retinoic acid receptor-beta (RARβ) agonist.

The present invention provides a tretinoin and benzoyl peroxide composition, its preparation method and use, which comprises component (i) benzoyl peroxide; component (ii) tretinoin; and (iii) a lipid material. The composition has excellent stability, and the preparation process is simple and easy to scale up production.

The present invention relates to a cosmetic composition containing a high concentration of retinoid to improve wrinkled skin, and more specifically, relates to a cholesteric liquid crystal cosmetic composition containing retinol, the composition having an excellent wrinkle-improving effect by containing a high concentration of retinoid while also being significantly less irritating to the skin.

The present invention relates to the use of a stable aqueous silicic acid solution in the preparation of a product for treating acne, wherein a mass concentration of the stable aqueous silicic acid solution is 0.5-2%. A product using the stable aqueous silicic acid solution as an active ingredient can be used for treating acne or for preventing and / or treating sebaceous gland dyshomeostasis. At a mass concentration of 0.5-2%, the product can lighten the color of sebaceous gland plaques, thereby achieving an anti-acne effect. Moreover, the stable aqueous silicic acid solution has a low raw material cost, is environmentally friendly and safe, and can thus be used as a highly therapeutically effective alternative to traditional tretinoin drugs.

The invention relates to compositions comprising urolithins with active agents, particularly compositions comprising urolithins and one or more retinoid compounds, for example, topical compositions of urolithins with one or more retinoids. The invention also relates to uses of such compositions, for use for the treatment or prevention of diseases, disorders and conditions, particularly diseases, disorder or conditions of the skin and hair, and for use in non-therapeutic treatments. The invention also related to a urolithin, for example, urolithin A, for use in reducing adverse effects of the administration of a retinoid compound.

The invention discloses a composition and a preparation method of fluocinolone hydroquinone tretinoin acid emulsifiable paste, and belongs to the field of pharmaceutical preparations. The fluocinolone hydroquinone tretinoin acid cream disclosed by the invention is simple in composition, stable in quality, simple, convenient and efficient in preparation process. Aiming at the problems that active ingredients of the fluocinolone hydroquinone tretinoin cream are poor in content uniformity and easy to crystallize and separate out, the low-content active ingredients fluocinolone and tretinoin are uniformly dispersed in a carrier material by using a melting adsorption granulation technology, and the rate of recovering a dispersed substance to a crystalline state is reduced by using the amorphous and adsorption characteristics of the carrier material; the surface free energy of the dispersed substance is reduced, the active component forms microcrystals or crystal grains are separated out, and the safety and the quality stability of the preparation are improved. Common equipment is used in the preparation process, industrial production can be achieved, and the preparation process is worthy of application and popularization.

The application provides a separation method and detection method for erythromycin, isotretinoin and BHT in isotretinoin erythromycin gel, and the separation method comprises: the detection method adopts high performance liquid chromatography to separate erythromycin, isotretinoin and BHT in isotretinoin erythromycin gel; and the high performance liquid chromatography conditions comprise that a Shimadzu shim-pack Scepter C18-120 column is used as a chromatographic column; a mixed mobile phase of mobile phase A and mobile phase B is used for gradient elution; the content of erythromycin, BHT and isotretinoin can be determined at the same time, which is convenient, fast and practical.

This specification provides compositions and methods for treating skin disorders. In particular, this specification provides compositions that enhance retinoid-based skin treatment while preventing side effects.

The present invention relates to a retinoic acid-alcohol amine complex consisting of retinoic acid and an alcohol amine compound. The complex is in liquid form at room temperature, has good water solubility / water dilution resistance and good skin penetration effect, and overcomes the limitation of retinoic acid compounds in the application field of drug products in the prior art, showing a wide prospect in medicine.