21 results about "Tretinoin" patented technology

The invention provides efficient mild whitening cream and a preparation method thereof. The raw materials of the cream comprise five phases A and E, the phase C contains 0.1-3% of a mixed solution of isosorbide dimethyl ether and hydroxyl pinacolone retinoate, and the phase D contains 0.01-0.1% of L-carnitine. Wherein the hydroxyl pinacolone retinoate can be specifically combined with an RAR / RXR (Region Receptor / Receptor X Receptor), and the expression of an MITF (Microphthalmia-associated Transcription Factor) gene is reduced, so that the melanogenesis is inhibited; l-carnitine promotes fatty acid beta-oxidation and enhances ATP synthesis to indirectly regulate and control AMPK activity; aMPK enhances transcriptional activity of a tretinoin receptor through phosphorylation of the tretinoin receptor, so that the AMPK and hydroxyl pinacolone retinoate exert a synergistic effect, jointly enhance whitening activity, effectively improve the phenomena of color spots and dark skin and promote the skin color to be uniform, bright and white; meanwhile, the isosorbide dimethyl ether can promote the transdermal absorption of the hydroxyl pinacolone retinoate, the L-carnitine and the related active ingredients.

The present application belongs to the field of biomedicine, and relates to an inducer for inducing mesenchymal stem cells to differentiate into estradiol-secreting cells. The inducer for inducing mesenchymal stem cells to differentiate into estradiol-secreting cells is based on a human mesenchymal stem cell serum-free culture medium, and is composed of the following components in a mass concentration ratio: bone morphogenetic protein-4 20-60 mg / L, bone morphogenetic protein-7 20-60 mg / L, tretinoin 2-8 mg / L, resveratrol 2-8 mg / L, icariin 2-8 mg / L, benzamide 2-8 ug / L, chloroplatinic acid hexahydrate 2-8 ug / L, ethanolamine 2-8 ug / L, erythropoietin 2-10 ug / L, and vascular endothelial growth factor 2-10 ug / L. The inducer for inducing mesenchymal stem cells to differentiate into estradiol-secreting cells has high induction efficiency.

The invention provides compositions and methods for providing a cardioprotective effect in a subject. Specifically, the invention provides compositions and methods for treating cardiovascular ailments, for example, ischemia / reperfusion (I / R) injury, cardiac arrhythmias, oxidative stress, or cardiac failure by administering a retinoic acid receptor-beta (RARβ) agonist.

The present invention provides a tretinoin and benzoyl peroxide composition, its preparation method and use, which comprises component (i) benzoyl peroxide; component (ii) tretinoin; and (iii) a lipid material. The composition has excellent stability, and the preparation process is simple and easy to scale up production.

The invention belongs to the technical field of fluorescent probes, and particularly discloses a novel fluorescent compound capable of being combined with a retinoic acid receptor related orphan receptor gamma normal site and application of the novel fluorescent compound serving as a fluorescent probe to inhibitor screening, imaging and the like. Compounds P1-P11 conforming to the general formula (I) are synthesized, a novel ROR gamma normal inhibitor screening platform can be established on the basis of a fluorescence polarization probe system constructed by the compounds according to a competitive ligand replacement principle, and the technical scheme breaks through the limitation of a traditional activity detection method and has a wide application prospect. An activity evaluation tool with economical efficiency, timeliness and reliability is provided for research and development of drugs targeting ROR gamma normal sites, and the lead compound discovery and structure optimization process can be accelerated.

The invention belongs to the technical field of biological medicines, and particularly relates to preparation and application of a nanoemulsion. The PDA / TEMPO NMsE nano-emulsion prepared by the invention can block lipid peroxidation chain reaction of a skin photoaging part and effectively reduce the inflammatory mediator level, and compared with retinoic acid or polydopamine, the PDA / TEMPO NMsE nano-emulsion has a more excellent skin photoaging treatment effect, can keep a protection effect for a long time, and has a good application prospect. The problem that the efficiency of removing alkoxy and alkyl peroxy free radicals by a single PDA material is insufficient is solved.

Provided is a composition for improving wrinkles including a high-content / sustained-release retinoid capsule. The high-content / sustained-release retinoid capsule according to the presently claimed subject matter can minimize skin side effects and maximize wrinkle improvement effects by significantly increasing the retinoid content in the capsule and stability and controlling the release rate.

The application discloses a kind of vitamin A derivative tablets, comprising: 11% to 12% of tretinoin, 83% to 87.8% of the compound of two microcrystalline celluloses, 1.0% to 2.0% of magnesium stearate by weight percentage;Microcrystalline cellulose is selected from TF series, TL series;Two microcrystalline celluloses are TF525 and TL565 respectively;The weight ratio of two microcrystalline celluloses is 32 to 39:39 to 45.The preparation method of tablet comprises:1) weighing: the raw and auxiliary materials are weighed according to the prescription amount, and passed through 40 mesh screen;2) total mixing: the material is added into wet granulator, the stirring speed is set to 220-280rpm, the shearing speed is set to 1000-1600rpm, and the mixing time is 5-10min;3) tabletting: the theoretical tablet weight is 180±13mg, and the hardness is controlled to 30-50N;4) coating: the coating weight gain is 3-5%;5) aluminum package: the heat sealing temperature is set to 110-140℃, and the main machine speed is 4-8rpm.The tretinoin tablet prepared in the application has good dissolution performance and stability.

The invention discloses a 9 cis-retinoic acid nano-liposome and a preparation method thereof. The preparation method comprises the following steps: under a dark condition, dissolving 9 cis-retinoic acid, hydrogenated soybean phosphatidylcholine, DSPEPEG2000 and cholesterol according to a specific weight part ratio in an organic solvent, carrying out reduced pressure rotary evaporation to form a lipid film, adding pure water for hydration, and finally controlling the ultrasonic power and time or the high-pressure homogenization pressure and cycle index to complete particle size control. Through the synergistic effect of the prescription and the process parameters, the nano-liposome with the encapsulation efficiency greater than 95% and good stability is successfully prepared, and the problems of low encapsulation efficiency and poor stability are effectively solved.

The present invention relates to the field of applied basic medical research, specifically to a method for inducing a zebrafish neural tube defect model using all-trans retinoic acid (ATRA). This invention establishes, for the first time, a zebrafish model of neural tube defects induced by all-trans retinoic acid (ATRA), providing a new zebrafish model for studying the mechanisms and treatments of neural tube defects caused by early pregnancy ATRA. The technical problem addressed by this invention is to establish a convenient, time-saving method that allows for direct in vitro observation of the embryonic neural tube development process. This novel method for inducing a zebrafish neural tube defect model has a high embryonic malformation rate and a low mortality rate.

The present invention relates to a cosmetic composition containing a high concentration of retinoid to improve wrinkled skin, and more specifically, relates to a cholesteric liquid crystal cosmetic composition containing retinol, the composition having an excellent wrinkle-improving effect by containing a high concentration of retinoid while also being significantly less irritating to the skin.

The present invention relates to the use of a stable aqueous silicic acid solution in the preparation of a product for treating acne, wherein a mass concentration of the stable aqueous silicic acid solution is 0.5-2%. A product using the stable aqueous silicic acid solution as an active ingredient can be used for treating acne or for preventing and / or treating sebaceous gland dyshomeostasis. At a mass concentration of 0.5-2%, the product can lighten the color of sebaceous gland plaques, thereby achieving an anti-acne effect. Moreover, the stable aqueous silicic acid solution has a low raw material cost, is environmentally friendly and safe, and can thus be used as a highly therapeutically effective alternative to traditional tretinoin drugs.

The invention relates to compositions comprising urolithins with active agents, particularly compositions comprising urolithins and one or more retinoid compounds, for example, topical compositions of urolithins with one or more retinoids. The invention also relates to uses of such compositions, for use for the treatment or prevention of diseases, disorders and conditions, particularly diseases, disorder or conditions of the skin and hair, and for use in non-therapeutic treatments. The invention also related to a urolithin, for example, urolithin A, for use in reducing adverse effects of the administration of a retinoid compound.

The invention discloses a composition and a preparation method of fluocinolone hydroquinone tretinoin acid emulsifiable paste, and belongs to the field of pharmaceutical preparations. The fluocinolone hydroquinone tretinoin acid cream disclosed by the invention is simple in composition, stable in quality, simple, convenient and efficient in preparation process. Aiming at the problems that active ingredients of the fluocinolone hydroquinone tretinoin cream are poor in content uniformity and easy to crystallize and separate out, the low-content active ingredients fluocinolone and tretinoin are uniformly dispersed in a carrier material by using a melting adsorption granulation technology, and the rate of recovering a dispersed substance to a crystalline state is reduced by using the amorphous and adsorption characteristics of the carrier material; the surface free energy of the dispersed substance is reduced, the active component forms microcrystals or crystal grains are separated out, and the safety and the quality stability of the preparation are improved. Common equipment is used in the preparation process, industrial production can be achieved, and the preparation process is worthy of application and popularization.

The present invention relates to a composition containing tretinoin, its preparation method, and its use. The composition comprises (a) a tretinoin-alcoholamine compound complex, (b) a gel matrix, and (c) an oil phase component. The composition has good ingredient compatibility, comfort in use, stability, safety, and skin permeability, and therefore has broad medicinal prospects.

The invention provides a method for detecting tretinoin and / or related substances thereof in a tretinoin preparation, and relates to the technical field of medicine detection. The method comprises the following steps: pre-treating a tretinoin preparation to be detected: mixing the preparation to be detected, a gel breaker and a diluent, carrying out solid-liquid separation operation, and collecting a liquid component which is a sample liquid to be detected; by adopting the pretreatment method, matrix interference in the preparation to be detected can be effectively removed. The to-be-detected sample solution is detected by high performance liquid chromatography, and rapid qualitative and quantitative analysis of tretinoin and seven related substances in the tretinoin preparation can be realized. Wherein the tretinoin and the seven related substances have good peak shapes, the separation degree of each substance is high, the accuracy of a detection result is high, the detection limit is low, the quantitation limit is low, the detection sensitivity is high, and the stability is strong. According to the detection method provided by the invention, the defect of detection of tretinoin and related substances in the tretinoin preparation in the prior art is overcome, and a technical support is provided for inspection and quality control of the tretinoin preparation.

The application provides a separation method and detection method for erythromycin, isotretinoin and BHT in isotretinoin erythromycin gel, and the separation method comprises: the detection method adopts high performance liquid chromatography to separate erythromycin, isotretinoin and BHT in isotretinoin erythromycin gel; and the high performance liquid chromatography conditions comprise that a Shimadzu shim-pack Scepter C18-120 column is used as a chromatographic column; a mixed mobile phase of mobile phase A and mobile phase B is used for gradient elution; the content of erythromycin, BHT and isotretinoin can be determined at the same time, which is convenient, fast and practical.

This specification provides compositions and methods for treating skin disorders. In particular, this specification provides compositions that enhance retinoid-based skin treatment while preventing side effects.

The present invention relates to a retinoic acid-alcohol amine complex consisting of retinoic acid and an alcohol amine compound. The complex is in liquid form at room temperature, has good water solubility / water dilution resistance and good skin penetration effect, and overcomes the limitation of retinoic acid compounds in the application field of drug products in the prior art, showing a wide prospect in medicine.

The invention relates to the field of cosmetics, in particular to a composition for inhibiting propionibacterium acnes, a preparation method of the composition and an acne removing cosmetic. The composition for inhibiting the propionibacterium acnes is prepared from the following components: a manglietia extract solution and a pionin solution, the mass ratio of the manglietia fordiana extract solution to the Paxonine solution is (1-4): (4-1). According to the technical scheme, the composition containing the manglietia fordiana extract solution and the Paionin solution is provided, and the composition can stably inhibit growth of propionibacterium acnes, so that the effect of removing acnes is achieved. The two components in the composition are in the ratio range, the synergistic interaction effect can be achieved, and the effect of inhibiting propionibacterium acnes is improved. The two components in the composition are green and environmentally friendly, and compared with chemical acne removing components such as salicylic acid, azelaic acid, benzoyl peroxide and tretinoin, the acne removing effect is stable, and the composition is green, natural and free of irritation and side effects.

The invention provides a preparation method of all-transretinoic acid and arsenic trioxide composite nano sustained-release microspheres, which comprises the following steps: a, adding albumin and L-reduced glutathione into deionized water, and carrying out reduction reaction on disulfide bonds in albumin molecules to obtain a reduced albumin aqueous solution; b, taking a sodium hydroxide solution of ATO, and then adding the sodium hydroxide solution of ATO into the reductive albumin aqueous solution obtained in the step a to obtain an ATO-albumin solution; c, ATRA is added into absolute ethyl alcohol and stirred, and an ethyl alcohol solution of ATRA is obtained; d, dropwise adding the ATRA ethanol solution obtained in the step c into the ATO-albumin solution obtained in the step b by using a micro-injection pump to obtain an ATRA and ATO composite nano sustained-release microsphere crude product; and e, centrifuging the crude product, cleaning with deionized water, and freeze-drying to obtain the microsphere product. The preparation method of the product is rapid, simple and convenient, the targeting property is strong, the effect of resisting tumor growth and metastasis of the medicine can be obviously enhanced, and the biological safety is good.