110 results about "Inflammatory mediator" patented technology

The invention relates to a diatomic iron-iron site nano-enzyme constructed by relieving oxidative stress and cartilage degeneration and used for targeted osteoarthritis treatment. According to the invention, a nitrogen-doped porous carbon anchored diatomic iron nano enzyme catalyst (Fe2-NCs) with Fe-Fe dimer coordination is developed by using a'subject-object 'strategy. The Fe2-NCs protect cartilage cells from oxidative stress induced apoptosis by modulating ROS and active nitrogen species (RNS) and promoting O2 release. In addition, Fe2-NCs restores mitochondrial function by inhibiting NOX4 expression, improving ATP production, and normalizing COXIV levels. In an in-vivo OA model, the Fe2-NCs can reduce the expression of a pro-inflammatory medium COX-2 through an NF-kappa B signal channel, inhibit the up-regulation of MMP-13 and delay the degradation of type II collagen. The invention provides a new theoretical framework and methodological approach for the treatment of osteoarthritis, and has important clinical and scientific significance.

The invention belongs to the technical field of microorganisms, and particularly relates to application of bifidobacterium longum in improving immunity and preparing products for preventing, treating and / or assisting in treating rhinitis. The preservation number of the bifidobacterium longum is GDMCC No: 65969, and the bifidobacterium longum can reduce the levels of MDA and NO in serum of mice and improve the activity of SOD and CAT and the content of GSH so as to relieve oxidative stress injury; inflammatory cell infiltration of nasal mucosa is reduced, and lung tissue inflammatory mediator level and inflammation-related gene expression are reduced to inhibit inflammation; th1 / Th2 immune balance is regulated, Th2 type cytokines are reduced, Th1 type cytokines are increased, and the high-dosage effect is close to that of loratadine. The strain has a treatment effect on allergic rhinitis through multiple mechanisms, and a new choice is provided for treatment of the strain.

The invention relates to application of roxburgh rose-derived exosomes (RrNVs) in preparation of products for preventing, improving or treating acute lung injury (ALI). Specifically, the rosa roxburghii tratt exosome (RrNVs) can effectively inhibit inflammation, improve the acute lung injury symptom, reduce the release of inflammatory cells and inflammatory mediators in the acute lung injury state, and relieve the pulmonary edema condition, the lung tissue leakage condition and the lung capillary permeability condition in the inflammatory state. Meanwhile, the RrNVs can also regulate and control the intestinal flora structure, improve the abundance of beneficial bacteria and reduce the abundance of harmful bacteria, and the discovery provides a basis for the RrNVs as potential functional food, medicine and the like of ALI.

A method for characterizing disease activity in a systemic lupus erythematosus patient (SLE), comprising obtaining a dataset associated with a blood, serum, plasma or urine sample from the patient, assessing the dataset for a presence or an amount of protein expression of at least one innate serum or plasma mediator, assessing the dataset for a presence or an amount of protein expression of at least one adaptive serum or plasma mediator biomarker, assessing the dataset for a presence or an amount of at least one chemokine / adhesion molecule biomarker, assessing the dataset for a presence or an amount of at least one soluble TNF superfamily biomarker, assessing the dataset for a presence or an amount of at least one inflammatory mediator biomarker, assessing the dataset for a presence or an amount at least one SLE-associated autoantibody specificity biomarker and calculating a Lupus Disease Activity Immune Index (LDAII) score.

The invention discloses a composition containing achillea millefolium extract, which is prepared from the following ingredients in percentage by weight: 45 to 55 percent of glycerol, 4 to 6 percent of hydrogenated lecithin, 3 to 5 percent of caprylic / capric triglyceride, 1 to 3 percent of 1, 2-hexanediol, 0.8 to 1.2 percent of achillea millefolium extract, 0.4 to 0.6 percent of ergothioneine and the balance of water. Through precise compounding of the achillea millefolium extract and the ergothioneine, the dual effects of anti-inflammation and skin repair are achieved, flavonoid and organic acid components in the achillea millefolium extract can effectively inhibit release of inflammatory mediators such as IL-6 and TNF-alpha, and sensitive symptoms such as red and swollen and pruritus are relieved.

The invention belongs to the field of daily chemicals, and particularly relates to a body cleaning composition containing folium artemisiae argyi extract and a preparation method of the body cleaning composition. 14%-20% of a surfactant; 0.5-5% of a skin conditioner; 0.01%-0.1% of a metal chelating agent; 0.01%-1.2% of a preservative; 0.01%-1% of a pH regulator; 1 to 1.5 percent of flavoring agent; 0.01%-1% of a viscosity modifier; and the balance of deionized water. The plant functional composition comprises a folium artemisiae argyi extract and a rosa canina fruit extract. The folium artemisiae argyi extract and the rosa canina fruit extract in the composition can achieve a synergistic effect, free radicals can be effectively removed, release of cell factors and inflammatory mediators can be inhibited, and the composition has anti-inflammatory and soothing effects, can relieve uncomfortable symptoms such as skin redness and itching and has a certain whitening effect.

The application provides a copper peptide efficient soothing composition and application thereof, which comprises copper peptide and symbiotic fermentation products of thermus thermophilus and bacillus, can target stimulation of secretion of inflammatory mediators, effectively inhibits secretion of PGE2 and expression of inflammatory factors IL-6, TNF alpha and NO, and has a synergistic effect, especially on secretion of PGE2 and expression of NO, and shows a more significant soothing effect. The composition is used as an efficacy component to prepare skin care products, is particularly suitable for people with sensitive skin, can help the skin to restore a healthy state, and has a good application prospect.

This invention relates to the use of recombinant type III humanized collagen and compositions comprising thereof in the ocular field. The invention provides the use of recombinant type III humanized collagen in the preparation of products for the prevention and / or treatment of ocular inflammation, and compositions comprising recombinant type III humanized collagen, and the use of these compositions in the preparation of products for the prevention and / or treatment of ocular inflammation and / or dry eye. Recombinant type III humanized collagen and compositions comprising thereof can significantly promote the renewal and repair of corneal epithelial cells, while inhibiting the release of inflammatory mediators, strengthening the ocular tissue barrier, enhancing tear film stability, and relieving ocular inflammation and dry eye.

This invention discloses an anti-inflammatory peptide derived from pearl oysters and its applications, relating to the field of bioactive peptide technology. The amino acid sequence of this anti-inflammatory peptide is TAMY. The anti-inflammatory peptide derived from pearl oysters provided by this invention can regulate the release of cellular inflammatory mediators, reduce the levels of NO and pro-inflammatory cytokines (such as TNF-α, IL-6, and IL-1β), and simultaneously promote the secretion of anti-inflammatory cytokines (such as IL-10), exhibiting excellent anti-inflammatory activity and suitable for use in functional foods, cosmetics, or pharmaceutical ingredients.

An orally administered composition for treating or reducing damage to connective tissue or for treating or reducing inflammatory symptoms associated with damage to connective tissue includes a synergistic combination of (i) avocado / soybean unsaponifiables; and (ii) a lipoic acid or a salt or derivative thereof. A method for treating or reducing damage to connective tissue, for treating or reducing inflammatory symptoms associated with damage to connective tissue, or for reducing the level of one or more inflammatory mediators in connective tissue includes administering the orally administered composition to an avian or mammalian subject.

The present disclosure relates to a cosmetic composition having anti-inflammatory activity. According to the present disclosure, provided is a cosmetic composition capable of inhibiting the production of an active nitrogen substance, which is an inflammatory mediator involved in the induction of inflammation in a cell.

The invention discloses a plant extract-containing composite antibacterial external spray for pets and a preparation method of the plant extract-containing composite antibacterial external spray, and belongs to the technical field of pet nursing materials. The external spray comprises the following components in percentage by mass: 0.5-1.0% of a cortex dictamni extract, 0.75-1.5% of a tomato fruit extract, 0.75-1.5% of a folium artemisiae argyi extract and 5-8% of anthemis nobilis hydrolat, and can also be matched with auxiliary components such as an emulsifier and a preservative. The cortex dictamni extract is prepared by combining a supercritical CO2 extraction method with a specific compound entrainer, and active ingredients are fully reserved; the spray is prepared through step-by-step preparation of a water phase and an oil phase and then high-shear emulsification, and the stability is good. The product shows a high bacteriostatic effect on staphylococcus aureus, salmonella and candida albicans, can significantly reduce the content of an inflammatory mediator NO and a proinflammatory factor IL-1beta, has bacteriostatic, bactericidal and anti-inflammatory effects, is suitable for preparation of pet skin care related products, and has a wide application prospect.

The invention discloses an application of a bee sugar plum seed alcohol extract in preparation of an anti-colitis medicine. The invention finds that the bee sugar plum seed alcohol extract inhibits the generation of LPS-induced pro-inflammatory mediators (NO) and pro-inflammatory cytokines (TNF-alpha, IL-6 and IL-1beta) under the condition of no cytotoxicity; the bee sugar plum seed alcohol extract inhibits transcription of LPS-induced pro-inflammatory cytokine genes and expression of genes and proteins of synthetic pro-inflammatory mediator enzymes (iNOS and COX-2); the bee sugar plum seed alcohol extract not only inhibits nuclear transfer of NF-kappa B by reducing phosphorylation and degradation of I kappa B alpha, but also inhibits phosphorylation of MPAKs (ERK, p38 and JNK); the traditional Chinese medicine composition has a remarkable inhibition effect on dextran sodium sulfate induced mouse colitis. Therefore, the bee sugar plum seed alcohol extract has a remarkable anti-inflammatory effect in vivo and in vitro, and can be used for treating colitis.

The application provides application of ABT199 in preparation of a drug for treating muscle atrophy. Compared with the prior art, the application provides a new use of ABT199 in treating muscle atrophy. Experimental research proves that ABT199 administration can significantly restore the exercise capacity of a cachexia-induced muscle atrophy mouse, improve the muscle cross-sectional area of the mouse, restore the reduced glutathione content of the mouse, and improve the superoxide dismutase activity, so as to improve the muscle atrophy phenotype of the mouse and muscle atrophy-related biochemical indexes. ABT199 can significantly restore cell muscle atrophy-related gene and protein expression, and improve the cachexia-induced muscle atrophy phenotype by reducing related inflammatory mediators; ABT199 can significantly improve the mitochondrial membrane potential, increase the expression of mitochondrial neogenesis-related genes, and reduce the production of active oxygen.

The application discloses a cyclic peptide compound with anti-inflammatory function and application thereof, and belongs to the technical field of polypeptide compounds, and particularly relates to a H-Phe-Lys(Boc)-Tyr(tBu)-Pro-Phe-CTC resin, i.e., a fully-protected peptide resin, which is prepared by using a solid-phase synthesis method; the fully-protected peptide resin is subjected to cutting treatment and cyclization treatment to obtain a cyclic peptide compound, and the structure of the cyclic peptide compound is Cyclo(Phe-Lys-Tyr-Pro-Phe-); the cyclization treatment further comprises deprotection cutting, and the cutting liquid in the deprotection cutting is formed by mixing TFA, Tis, EDT, PhOH and H2O.The application is a cyclic peptide compound with anti-inflammatory function, which has small cytotoxicity, good safety, can inhibit inflammatory factors and can inhibit the gene expression of inflammatory mediators, and application thereof.

The present invention relates to a novel Latilactobacillus curvatus strain WiKim0169 having immunoenhancing efficacy, and an immunoenhancing composition comprising same. In the present invention, it was found that the Latilactobacillus curvatus strain WiKim0169, which is a novel kimchi-derived strain, significantly increases splenic NK cell activity and increases the production of inflammatory mediators, immunoglobulins, and cytokines, thereby alleviating immunosuppressive responses. In addition, it was confirmed that the Latilactobacillus curvatus strain WiKim0169 has an effect of alleviating immune dysfunction by increasing the mRNA expression levels of iNOS, COX2, TNF-α, IL-1β, IL-6, IL-2, IL-12, and IL-10 in splenic tissue and increasing the phosphorylation levels of NF-κB and IκBα. Therefore, according to the present invention, the composition comprising the Latilactobacillus curvatus strain WiKim0169, which is a novel kimchi-derived strain, as an active ingredient is expected to be usefully employed as a pharmaceutical and functional food composition for immunoenhancement.

The invention provides application of inflammatory mediator combined collagenase in construction of an animal corneal thinning model, and belongs to the technical field of construction of animal models. According to the method, an inflammatory mediator and collagenase are combined, a novel mouse keratoconus model with the thinned cornea is constructed and obtained, and the deficiency of a keratoconus animal model is made up. Researches show that after the inflammatory mediator is combined with collagenase to construct a mouse cornea thinning model, the cornea thickness of a mouse can be obviously thinned, and the occurrence and development of keratoconus are promoted.

The application discloses a composition with soothing anti-inflammatory anti-wrinkle firming efficacy and a preparation method thereof, and the composition comprises a TRPV1 inhibitor, an extract of Glycyrrhiza inflata Bat., palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7. The four raw materials are compounded to have a synergistic effect, reduce the release of pro-inflammatory mediators and inhibit the high reactivity of nerve fibers to achieve soothing anti-inflammatory and anti-irritation; promote the generation of self collagen and sodium hyaluronate, reduce the oxidative stress response to achieve the anti-wrinkle firming efficacy and delay skin aging. The composition has comprehensive effects in soothing, anti-inflammatory, anti-irritation, anti-oxidation, anti-wrinkle and firming, reduces the generation of inflammation and delays skin aging, relieves the burning and stinging sensation of the skin at the same time, and meets the requirements of safety and high efficiency pursued by sensitive skin groups.

The present invention discloses a crotan-type diterpene compound, its preparation method, and application, relating to the field of pharmaceutical technology. The present invention extracts a crotan-type diterpene compound of novel structure from sage. The compound has significant inhibitory activity against neuronal inflammation, exhibits excellent anti-neuritis effects, and significantly inhibits inflammatory mediators. It can be developed as a therapeutic drug for neurodegenerative diseases.

The invention belongs to the technical field of medicines, and discloses application of a compound M1 shown as a formula (I) and pharmacodynamically acceptable salt thereof in preparation of medicines for preventing, relieving and / or treating autoimmune demyelination diseases. On a mouse experimental autoimmune encephalomyelitis model, the compound M1 shows a good treatment effect, can effectively prevent and treat pathological changes and disease progression of diseases, relieve the severity of the diseases and inhibit LPS-stimulated microglial BV2 cells from releasing inflammatory mediators, and provides a new drug and a new structure for clinical treatment.

The invention provides a formula for centipede stings and bites and a preparation method thereof. Comprising the following raw materials: acidic liquid, nail powder and an analgesic and anti-inflammatory synergist, the acidic liquid is white vinegar or fruit vinegar; the formula provided by the invention is scientific and reasonable, all the components have a synergistic effect, the effect is remarkable, the white vinegar can directly neutralize main acid toxins in centipede venom, the main component of the nail powder is keratin, and the keratin can be hydrolyzed and swelled to a certain degree in an acid environment to form a protective layer, so that external stimulation can be isolated, and the nail powder can be effectively prevented from being damaged. The added analgesic and anti-inflammatory synergists such as menthol and borneol have natural cooling, paralysis and transdermal promotion effects and can instantly act on nerve endings to generate strong cold feeling so as to transfer and cover pain signals, and permeation of other effective components is promoted; meanwhile, the components also have certain anti-inflammatory characteristics and can synergistically inhibit release of local inflammatory mediators, so that the fading of red and swollen is accelerated.

The invention discloses a novel traditional Chinese medicine honeyed pill for treating alopecia, and relates to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: radix rehmanniae praeparata, angelica sinensis, raw radix paeoniae alba, semen cuscutae fried with wine, radix saposhnikoviae, gastrodia elata, ligusticum wallichii, radix ophiopogonis, asparagus cochinchinensis, radix bupleuri, radix puerariae, cassia twig, radix curcumae, caulis spatholobi and other traditional Chinese medicines which are subjected to superfine grinding and then are matched according to a specific proportion. The preparation process comprises the steps of crushing; refining honey; and mixing and waking up the medicine. The traditional Chinese medicine composition has the following effects: the composition takes effect at multiple targets: up-regulating hair follicle survival promoting factors and down-regulating inflammatory mediators; the process has the advantages that the stability of pills is improved by controlling the viscosity of refined honey; the clinical application has the advantages that the cure rate of severe alopecia totalis is improved compared with the traditional prescription The recurrence rate is low after the medicine is stopped for one year. The formula is mainly used for treating alopecia, alopecia areata, sticktight and alopecia totalis.

The invention discloses a chalcone substituted compound, a preparation method thereof and application of the chalcone substituted compound in preparation of anti-inflammatory drugs, and relates to the field of medicinal chemistry. In particular relates to chalcone substituted compounds, a preparation method thereof, a pharmaceutical composition containing the compounds and medical application thereof, and particularly, the chalcone substituted compounds can remarkably inhibit generation of inflammatory mediators and have important application potential and clinical value in treatment of inflammation-related diseases. Based on the molecular hybridization principle, the chalcone substituted compound is prepared through a chemical synthesis method, and experiments show that the compound has remarkable advantages in the aspect of inhibiting generation of inflammatory mediators (such as NO) and has the application potential of developing novel anti-inflammatory drugs.

This invention discloses the application of chestnut total burr ethanol extract in the preparation of anti-colitis drugs. In this invention, the chestnut total burr ethanol extract with anti-colitis properties is obtained by extracting chestnut total burrs with 70% ethanol. This chestnut total burr ethanol extract inhibits the production of LPS-induced pro-inflammatory mediators (NO) and pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) without cytotoxicity; it has a significant inhibitory effect on dextran sulfate sodium-induced colitis in mice, including slowing down weight loss, reducing mouse DAI scores, alleviating colonic tissue damage, downregulating the levels of IL-6, IL-1β, TNF-α, and MDA in mouse colonic tissue and serum, and enhancing the activities of CAT and SOD in mouse colonic tissue and serum. Therefore, the chestnut total burr ethanol extract has significant anti-inflammatory effects both in vivo and in vitro, and can be used to treat colitis.

A microorganism containing Bacteroides fragilis genes is used as an active ingredient in the preparation of pharmaceuticals, medical devices, or food for treating optic nerve damage. This delivers Bacteroides fragilis (or its functional components) into the gastrointestinal tract, which helps maintain the number of retinal ganglion cells and the thickness of the retinal nerve fiber layer, inhibits the activation of retinal microglia, inhibits the activation of retinal inflammatory pathways and the expression of inflammatory mediators, thereby protecting visual function.

The present invention includes a method of characterizing disease activity in a systemic lupus erythematosus patient (SEE), comprising: obtaining a dataset associated with a blood, serum, plasma or urine sample from the patient, wherein the dataset comprises data representing the level of one or more biomarkers in the blood, serum, plasma or urine sample from each of (b) to (g); at least one innate serum or plasma mediator biomarker; at least one adaptive serum or plasma mediator; at least one chemokine / adhesion molecule biomarker; at least one soluble TNF superfamily biomarker; the inflammatory mediator biomarker SCF; at least one SLE-associated autoantibody specificity biomarker; and calculating a Lupus Disease Activity Immune.

The invention belongs to the technical field of biological pharmacy, and particularly relates to a sweet osmanthus lipstick for preventing and treating cheilitis and fading cheilogramma. In the composition disclosed by the invention, the osmanthus fragrans extract can reduce transcription of proinflammatory factors by inhibiting two signal channels of NF-kB and AP-1, so that generation of inflammatory mediators is reduced; the bisabolol has remarkable anti-inflammatory and soothing effects and can effectively relieve inflammation symptoms such as red and swollen lips and pain. The radix arnebiae seu lithospermi extract has the effects of clearing away heat and toxic materials and cooling and activating blood, and further enhances the anti-inflammatory effect. Phytosphingosine can promote repair and regeneration of lip cells and accelerate healing of damaged lip skin.

The microorganism contains the bacteroides fragilis gene, and the bacteroides fragilis gene is used as an active ingredient to be applied to preparation of medicine or food for treating optic nerve damage, the bacteroides fragilis (or functional components thereof) is delivered to gastrointestinal tracts, the number of retinal ganglion cells and the thickness of a retinal nerve fiber layer can be maintained, activation of retinal microglia cells is inhibited, and optic nerve damage is inhibited. Retina inflammation pathway activation and inflammatory mediator expression are inhibited, so that the visual function is protected.

The invention discloses a traditional Chinese medicine preparation for treating viral pneumonia. The traditional Chinese medicine preparation comprises the following components in parts by weight: 10-20 parts of ginseng, 9-15 parts of parasitic loranthus, 4-6 parts of schisandra chinensis, 6-9 parts of gastrodia elata, 6-9 parts of cassia twig, 6-9 parts of divaricate saposhnikovia root, 3-4.5 parts of prepared fructus evodiae, 10-20 parts of salvia miltiorrhiza, 6-9 parts of angelica sinensis, 6-9 parts of ligusticum wallichii, 8-12 parts of cortex moutan, 6-9 parts of radix paeoniae rubra, 6-9 parts of pericarpium citri reticulatae, 6-9 parts of rhizoma pinellinae praeparata and 6-9 parts of honey-fried The traditional Chinese medicine preparation disclosed by the invention is high in effective rate, can quickly relieve inflammatory response and remarkably reduce release of inflammatory mediators, and can quickly bring down a fever of a patient, and the average time is about 29 hours.