172 results about "Adjuvant therapy" patented technology

The invention discloses injectable hydrogel for photo-thermal adjuvant therapy of periodontitis and a preparation method, and belongs to the technical field of high polymer material preparation, the preparation method comprises the following steps: reacting MXene dispersion liquid with epigallocatechin gallate and MgSO4; then sequentially carrying out ultrasonic treatment, centrifugation, washing and freeze-drying to obtain a multifunctional nanosheet MP-Mg; adding the multifunctional nanosheet MP-Mg into an oxidized gellan gum aqueous solution, and carrying out a mixed reaction to obtain a solution A; mixing the quaternary ammonium salt chitosan aqueous solution and the carboxymethyl chitosan aqueous solution in equal volume, and reacting to obtain a solution B; and mixing the solution A and the solution B in equal volume for reaction. The hydrogel prepared by the preparation method disclosed by the invention has injectability, photo-thermal responsiveness, biological membrane penetrability, synergistic antibacterial property and long-acting anti-inflammatory property, and an innovative and practical photo-thermal adjuvant therapy platform is provided for clinical treatment of periodontitis.

The invention belongs to the technical field of microorganisms, and particularly relates to application of bifidobacterium longum in preparation of products for prevention, treatment and / or adjuvant treatment of pneumonia. The preservation number of the bifidobacterium longum is GDMCC No: 65969, and the bifidobacterium longum can improve the body weight decrease trend of a pneumonia mouse and reduce the lung visceral organ index of LPS increase; the content of pro-inflammatory factors such as IL-1beta, TNF-alpha and IL-6 in serum is remarkably reduced, mRNA expression of inflammation-related genes such as COX-2, IFN-gamma and TNF-alpha in lung tissue is reduced, and dose dependence is achieved; meanwhile, alveolar structure damage and inflammatory cell infiltration of mouse lung tissue are relieved, and lung tissue pathological damage is repaired. The strain can be used as a core component for developing pneumonia prevention or adjuvant therapy related products, provides a novel microbial intervention means for pneumonia prevention and treatment, and has important application value.

The invention belongs to the field of nano-medicine and traditional Chinese medicine, and particularly discloses an antioxidant nano-material based on self-assembly of traditional Chinese medicine and copper ions and a preparation method thereof.The nano-material is prepared from BPCu nano-particles formed by self-assembly of berberine and procyanidine B2 under induction of the copper ions, the BPCu nano-particles are further subjected to surface modification through polyvinylpyrrolidone, and the antioxidant nano-material is prepared. And the stably dispersed PVP-coated BPCu nano structure is obtained. The material is small in particle size, uniform in distribution, good in water solubility and storage stability, excellent in free radical scavenging capacity and catalase-like activity and suitable for adjuvant therapy of oxidative stress related diseases, and the preparation method is easy and convenient to operate, does not need an organic solvent and has good industrialization and disease treatment potential.

The invention belongs to the technical field of microorganisms, and particularly relates to application of bifidobacterium longum in improving immunity and preparing products for preventing, treating and / or assisting in treating rhinitis. The preservation number of the bifidobacterium longum is GDMCC No: 65969, and the bifidobacterium longum can reduce the levels of MDA and NO in serum of mice and improve the activity of SOD and CAT and the content of GSH so as to relieve oxidative stress injury; inflammatory cell infiltration of nasal mucosa is reduced, and lung tissue inflammatory mediator level and inflammation-related gene expression are reduced to inhibit inflammation; th1 / Th2 immune balance is regulated, Th2 type cytokines are reduced, Th1 type cytokines are increased, and the high-dosage effect is close to that of loratadine. The strain has a treatment effect on allergic rhinitis through multiple mechanisms, and a new choice is provided for treatment of the strain.

Disclosed are multi-peptide compositions and / or methods of use of the multi-peptide compositions for patients with resected (or definitively treated) high-risk uveal melanoma. Pharmaceutically acceptable embodiments administered to patients may raise an immune system response against uveal melanoma cells, leading to a decrease in uveal melanoma cell number. Further embodiments may take the form of an adjuvant therapy or a neoadjuvant therapy, as monotherapy or in combination with other therapies.

The invention provides a breast cancer adjuvant therapy pathology complete remission prediction method and electronic device.The breast cancer adjuvant therapy pathology complete remission prediction method comprises the steps that at the first stage, based on multi-time-point and multi-parameter MRI images of a patient before and after adjuvant therapy, the breast cancer adjuvant therapy pathology complete remission prediction result is obtained; training an image feature encoder with a tumor dynamic change identification capability through a dynamic supervision pre-training mode; and a second stage of constructing a multi-modal deep fusion network based on the image feature encoder to integrate the image features, radiomics features and clinical pathological features of the patient, and outputting a prediction result of complete pathology remission, the radiomics features being extracted from the MRI image. And the purposes of high precision and strong generalization capability are achieved.

This invention discloses a multi-target synergistic anti-liver cancer medical food granule and its preparation method. The granule uses medicinal and edible homologous foods and novel resource foods as raw materials, and is composed of curcumin extract, esterified fat-soluble EGCG, Moringa leaf powder, yeast β-glucan, Astragalus extract, Schisandra extract, Salvia miltiorrhiza extract, Poria cocos powder, resistant dextrin, and erythritol in a specific ratio to construct a three-dimensional synergistic system of "direct killing-immune regulation-liver protection," which can induce ferroptosis in liver cancer cells, inhibit protective autophagy, activate the body's immunity, and protect liver cells. This invention employs directional extraction, multi-layer coating, and high-pressure fusion granulation technology. Nanoparticle liposome encapsulation, esterification modification, and pH-responsive enteric coating improve the stability and bioavailability of the components, solving the problems of poor water solubility, low absorption, and easy degradation of natural active ingredients. The granule has clear efficacy, high safety, and stable process, and can be used as a medical food for adjuvant therapy and nutritional support during the recovery period of liver cancer.

The invention relates to the technical field of biological medicine, and relates to a polypeptide in targeted combination with SOX2 protein and application thereof, the polypeptide has an amino acid sequence as shown in SEQ ID NO.1, or has at least 85%, 90%, 95% or more than 99% of sequence identity with the amino acid sequence; the polypeptide inhibits phase separation of SOX2, liquid drops formed by phase separation of SOX2 can be avoided, then the situation that the liquid drops wrap chemotherapeutic drugs, influence the curative effect of the chemotherapeutic drugs and cause tolerance of tumor cells to the chemotherapeutic drugs is avoided, and the polypeptide does not influence the transcription activation function of SOX2 serving as a transcription factor; the polypeptide can inhibit the phase separation of the SOX2, so that the regulation of normal physiological functions, such as high expression in organs such as eyes of a human body, of the SOX2 as a transcription factor is not influenced, and therefore, the polypeptide disclosed by the invention can reverse chemotherapy drug resistance of tumors such as squamous carcinoma by inhibiting the phase separation of the SOX2, can be used for adjuvant therapy of the tumors such as squamous carcinoma, and has no obvious toxic or side effect on each organ of an organism.

The invention provides a composition. The composition is prepared from probiotics, a plant extract and acceptable auxiliary materials according to a specific content ratio. Wherein the probiotics comprise the following components: Weizmannia coagulans AUSA001, Lactobacillus plantarum AUSA002, Bifidobacterium longum subsp. Longum FL006, and the probiotics comprise the following components: the Weizmannia coagulans AUSA001, the Lactobacillus plantarum AUSA002, the Bifidobacterium longum subsp. Longum FL006, the Lactobacillus plantarum AUSA002 and the Bifidobacterium longum subsp. Longum FL006. The plant extract comprises a kudzuvine root extract, a grape seed extract and a turmeric extract. The composition has a synergistic effect, can reduce the content of human intestinal trimethylamine and serum trimethylamine oxide, and is used for prevention or adjuvant therapy of related diseases.

The invention belongs to the field of gout prevention and treatment, and particularly relates to alpinia oxyphylla and turmeric tabletted sweets as well as a preparation method and application thereof. According to the alpinia oxyphylla and turmeric composition disclosed by the invention, alpinia oxyphylla and turmeric are taken as main components, the beautiful millettia root, the poria cocos, the kudzuvine root, the lithocarpus litseifolius, the purslane, the cassia seed, the black pepper and the dandelion are reasonably combined, and all the components are synergistically interacted, so that the prepared composition can remarkably improve the xanthine oxidase inhibition activity, can effectively relieve gout symptoms, and can be used for treating gout. The composition can be used for adjuvant therapy of gout patients. The tablet candy prepared by adding a sweetening agent into the alpinia oxyphylla turmeric composition disclosed by the invention is simple in preparation process, can be eaten for a long time as an auxiliary food in a gout treatment process, and has a great promoting effect on relieving gout symptoms.

Provided is a method of treating a glioblastoma multiforme (GBM) disease or tumor in a subject in need thereof, comprising administering to the subject an adjunct therapy comprising a Gardos channel inhibitor (GCI) or a pharmaceutically acceptable salt or ester thereof, in association with a course of radiation treatment.

Apparatuses and methods for using augmented / mixed reality in surgical settings are provided, and, in particular, apparatuses and methods for intraoperative integration of augmented / mixed reality 3D models with near real-time pathology results. Real-time pathology results are generated using a machine learning analysis of biopsy pathology images in conjunction with a predictive model based on the patient's clinical and demographic data and radiographic imaging data. The apparatuses and methods can be used to provide more accurate intraoperative visualization, tracking, and determination of tumor margins to improve resection extent and any intraoperative or postoperative adjuvant therapy.

The application discloses a kind of Baicalein-loaded mPEG-PLGA nanoparticles based on tumor microenvironment and its preparation method and application.The method is: ultrasonic dispersion preparation Baicalein uniform solution;Then mPEG-PLGA is prepared;Emulsion evaporation method is prepared Baicalein-loaded mPEG-PLGA nanoparticles (PMs-Ba);The nanoparticles can be accumulated in tumor site, improve tumor microenvironment, so as to enhance the sensitivity of breast cancer to chemotherapeutic drugs.The method is simple to operate, provides a new idea for traditional Chinese medicine to be used as adjuvant therapy, and the method has great application potential in early cancer clinical treatment.

The utility model discloses a rhinitis adjuvant therapy device, which comprises a head-mounted structure, an air processor, a control assembly, a filter part, a fan assembly and a cambered mask plate, and is characterized in that the air processor, the control assembly, the filter part and the fan assembly are mounted in the head-mounted structure; the head-mounted structure is provided with a first flow channel located in the head-mounted structure, an air inlet communicated with the first flow channel and an outer connector used for being connected with an atomization piece, the mask plate is provided with a second flow channel located in the head-mounted structure and an air outlet communicated with the second flow channel, the two ends of the mask plate are connected with the head-mounted structure, and the first flow channel is communicated with the second flow channel; the air processor is located between the first flow channel and the air inlet and connected with the external connector, a fan assembly is arranged in the first flow channel, the filtering piece is arranged between the air processor and the fan assembly, and the control assembly is electrically connected with the air processor and the fan assembly. The rhinitis auxiliary treatment device solves the problems that an existing rhinitis auxiliary treatment device lacks portability and is single in function.

The present invention provides anti-CD73 binding molecules, such as antibodies and their antigen-binding fragments. [Solution] Provided are isolated binding molecules or antigen-binding fragments thereof that contain an antibody VL and specifically bind to CD73 having a specific sequence. Furthermore, pharmaceutical formulations comprising the disclosed composition, as well as methods for diagnosing and treating diseases associated with CD73 expression, such as cancer, are also provided. Such diseases can be treated, for example, by direct therapy with the disclosed anti-CD73 binding molecule (e.g., a naked antibody or antibody-drug conjugate that binds to CD73), by adjuvant therapy with other antigen-binding anticancer agents such as immune checkpoint inhibitors (e.g., anti-CTLA-4 and anti-PD-1 monoclonal antibodies), and / or by combination therapy in which the anti-CD73 molecule is administered before, after, or concurrently with chemotherapy.

The invention discloses a targeting peptide for blocking combination of IL-17A and IL-17RA / RC and application thereof, the targeting peptide is selected from AZS-1, AZS-2, AZS-3, AZS-4 and AZS-5 or a combination of any one of AZS-1, AZS-2, AZS-3, AZS-4 and AZS-5 and IBP, the amino acid sequence of AZS-1 is as shown in SEQ ID NO: 1, the amino acid sequence of AZS-2 is as shown in SEQ ID NO: 2, the amino acid sequence of AZS-3 is as shown in SEQ ID NO: 3, the amino acid sequence of AZS-4 is as shown in SEQ ID NO: 4, and the amino acid sequence of AZS-5 is as shown in SEQ ID NO: 5. The amino acid sequence of the AZS-5 is as shown in SEQ ID NO: 5, and the amino acid sequence of the IBP is as shown in SEQ ID NO: 6. The targeting peptide provided by the invention has good tolerance, can generate effective interaction with the surface of a target protein, can realize specific binding with IL-17A, has relatively high blocking ability, can effectively improve symptoms of liver and kidney cell injury, cell edema and skin injury caused by psoriasis after being applied to a psoriasis mouse model, and has a good application prospect. The compound has a good application prospect in treatment and / or adjuvant therapy of IL-17A-mediated inflammatory diseases.

The invention discloses application of ellagic acid in preparation of a medicine for preventing or treating ionizing radiation injury, and belongs to the technical field of biological medicine and radiation protection. Experiments prove that ellagic acid with an effective concentration can inhibit lipid peroxidation, enhance the activity of glutathione transferase and superoxide dismutase and promote the expression of antioxidant related genes such as sod-1, sod-2, gst-1 and gst-29 and immune related genes such as lys-1, irg-1, irg-2 and mul-1, so that the ellagic acid with an effective concentration can inhibit lipid peroxidation and improve the activity of glutathione transferase and superoxide dismutase. Therefore, oxidative damage, inflammatory response, reduced stress tolerance, accelerated aging and shortened service life caused by ionizing radiation exposure are relieved, and the compound can be applied to preparation of drugs for preventing or treating ionizing radiation damage and is suitable for nuclear accident emergency protection, space radiation protection of astronauts and adjuvant therapy of tumor radiotherapy patients. The invention provides a theoretical basis for developing an efficient and low-toxicity ionizing radiation protective agent based on ellagic acid, and has a wide application prospect.

This disclosure provides methods for treating tumors, reducing tumor severity, inhibiting tumor growth, or inducing tumor necrosis, wherein the methods include: selecting a patient with cancer (e.g., liver cancer, lung cancer, or head and neck cancer) in need of treatment and administering neoadjuvant therapy to the patient in a combination of a therapeutically effective amount of a programmed death 1 (PD-1) inhibitor (e.g., cimiprimab or its bioequivalent) and radiation therapy (e.g., SBRT) or an anti-LAG-3 antibody (e.g., fenpromab), followed by surgical resection and optionally administration of a programmed death 1 (PD-1) inhibitor (e.g., cimiprimab or its bioequivalent) as postoperative adjuvant therapy. In some embodiments, the cancer is liver cancer, such as hepatocellular carcinoma (HCC).

The application provides a breast cancer patient lymph node metastasis prediction model without clinical pathological characteristics, comprising the following steps: after three-dimensional reconstruction of two-dimensional lung enhanced CT films, an axillary lymph node atlas is established, all axillary lymph nodes in the atlas are selected as ROI regions, and more than 5 combined image features of each axillary lymph node are selected to distinguish whether breast cancer has axillary lymph node metastasis; and a logistic regression machine learning prediction model is used to construct the breast cancer patient axillary lymph node metastasis prediction model. The model established by the application can non-invasively predict whether breast cancer has axillary lymph node metastasis, the clinical pathological characteristics of the patient are not included in the model, and the image cutting in the model is not based on breast tumors, but based on axillary lymph nodes; the model is used to determine a suitable axillary treatment scheme, thereby avoiding unnecessary axillary surgery and complications, and helping to carry out more accurate surgery and adjuvant therapy mode of breast cancer.

The utility model provides a tumor nursing adjuvant therapy device, and relates to the technical field of medical instruments, the tumor nursing adjuvant therapy device comprises a supporting mechanism, a second stand column is arranged at the top of the supporting mechanism, a sliding groove is formed in one side of the second stand column, a lead screw is arranged in the sliding groove through a bearing, and a motor is fixedly mounted at the top of the second stand column; an output shaft of the motor is fixedly connected with one end of the lead screw, the outer surface of the lead screw is in threaded connection with a sliding block, a bearing plate is fixedly installed on one side of the sliding block, a leg supporting plate is arranged at the top of the bearing plate, an inserting groove is formed in the top of the bearing plate, an inserting block is inserted into the inserting groove, and the inserting block is fixedly connected with the bottom of the leg supporting plate. Through the motor and the lead screw, the lead screw can drive the bearing plate to move up and down under driving of the motor, then the leg supporting plate can be driven to ascend and descend, the height of the leg supporting plate can be adjusted, and the individual differences of different patients can be met by flexibly adjusting the height of the leg supporting plate.

The invention relates to a biodegradable slow-release film, a preparation process and an intracranial postoperative adjuvant therapy method. The film comprises a film base material and a medicine component, the film base material is a biodegradable high polymer material, and the medicine component can be slowly released along with the gradually degraded film base material. According to the treatment scheme provided by the invention, local administration is directly carried out on the wound surface in the brain, residual tumor cells and a tumor microenvironment are directly targeted after the drug is slowly released, the local concentration and the treatment effect of the drug are greatly improved, meanwhile, far-end relapse is prevented by activating systemic immune memory, and serious toxic and side effects caused by systemic administration are avoided; a multi-layer electrostatic spinning structure is utilized to realize sequential controlled release of different drugs, and the natural process of immune response is simulated; therefore, the pain of a patient and the operation risk are reduced.

The invention discloses a composition for improving osteoporosis as well as a related product and application thereof, and relates to the technical field of biology. According to the invention, a composition system with stable coexistence and mutual synergism of the components is constructed by regulating and controlling the variety and proportion of the active components, and the main materials comprise 1-10 parts of folium cortex eucommiae and 1-20 parts of bifidobacterium lactis. According to the system, the problem that the efficacy is reduced due to improper component proportioning in a traditional compound is solved, and the overall stability and bioavailability are also remarkably improved. In terms of functions, the composition comprehensively regulates bone metabolism balance by means of a multi-target and multi-channel synergistic mechanism, and a safer, more efficient and more stable new way is provided for prevention and adjuvant therapy of osteoporosis.

The invention belongs to the technical field of human body electroencephalogram signal processing and brain regulation and control. The invention provides an ultrasonic-electrical stimulation collaborative lymphatic system enhanced closed-loop regulation and control system, which integrates noradrenaline oscillation core driving signals to realize sleep staging and conversion detection, decides an ultrasonic-electrical stimulation collaborative mode based on a staging coupling index, completes parameter linear transition in a conversion period, and improves sleep quality. Stimulation parameters are dynamically optimized in combination with reinforcement learning and a PID fusion algorithm. According to the device, the defects of core signal deficiency, inaccurate stimulation coordination, one-sided coupling analysis and poor safety adaptability of an existing device are overcome, the lymphatic system metabolic waste removal efficiency is remarkably improved, the sleep interruption risk is reduced, regulation and control are accurate, safety and noninvasive are achieved, the device is suitable for prevention and adjuvant therapy of neurodegenerative diseases such as Alzheimer's disease, and the device has a wide application prospect. And the method can also be expanded to be used for lymphatic-like function mechanism research and early disease screening.

The invention discloses a composition for improving osteoporosis as well as a related product and application thereof, and relates to the field of biology. By accurately optimizing the ratio of the rhizoma polygonati to the colostrum basic protein to the folium cortex eucommiae to the bifidobacterium lactis, a composition system with stable coexistence and synergistic interaction among the components is constructed. The system not only effectively overcomes the problem that the efficacy is reduced due to mutual restriction and proportion imbalance of common components in a traditional compound, but also obviously improves the stability and bioavailability of the composition. In the aspect of efficacy, the composition comprehensively regulates and controls bone metabolism balance through a multi-target and multi-channel synergistic effect, the technical bottleneck that a single component or a simple mixture is limited in effect and incomplete in curative effect is fundamentally overcome, and a safer, more efficient and more stable solution is provided for prevention and adjuvant therapy of osteoporosis.

The invention discloses a fermented chicory composition with xanthine oxidase inhibitory activity as well as a preparation method and application of the fermented chicory composition. The composition is prepared by taking chicory roots as a single plant raw material and fermenting the chicory roots with a composite flora consisting of lactobacillus plantarum, lactobacillus rhamnosus, bifidobacterium adolescentis and streptococcus thermophilus in a viable count ratio of 1: 1: 1: 1. The preparation method comprises the steps of culture medium preparation, inoculated fermentation and post-treatment. Through the synergistic fermentation effect of the specific flora and the chicory substrate, the xanthine oxidase inhibitory activity of the product is remarkably enhanced. Metabonomics analysis shows that various active ingredients such as phenolic acids and prebiotic oligosaccharides are remarkably enriched after fermentation, and a dual-action mechanism of directly inhibiting enzyme activity and indirectly regulating intestinal flora is formed. The composition is safe in raw materials and definite in effect, and can be used for preparing medicines, health-care foods or dietary supplements for prevention or adjuvant treatment of hyperuricemia, gout and related diseases.

The invention belongs to the technical field of biomedicine, and discloses an antibody for evaluating the curative effect of infantile pneumonia asthma and application of the antibody. The heavy chain CDR sequence of the monoclonal antibody (secreted by the hybridoma cell strain 2B5) is SEQ ID NO: 2-4, the light chain CDR sequence of the monoclonal antibody (secreted by the hybridoma cell strain 2B5) is SEQ ID NO: 6-8, the dissociation constant of the monoclonal antibody and an IL-5R antigen reaches 2.435 * 10 <-1 > / L, and the affinity is high. The antibody can accurately evaluate the curative effect of infantile pneumonia and asthma by detecting the lung function, the ratio of eosinophilic granulocytes in bronchoalveolar lavage fluid and lung tissue inflammation, can also significantly improve airway obstruction and inflammation of asthma model mice, has an effect superior to that of dexamethasone, solves the problems that existing curative effect evaluation is lack of specific tools and has large side effects of therapeutic drugs, and has good clinical application prospects. And a new scheme is provided for curative effect evaluation and adjuvant therapy of infantile pneumonia asthma.

The invention discloses an auxiliary treatment intelligent sleep bin, and relates to the technical field of sleep bins, the auxiliary treatment intelligent sleep bin comprises a bin body, a supporting block is fixedly connected to the bottom of the bin body, pulleys are arranged at the bottom of the supporting block, a liquid crystal touch display screen is arranged on the circumferential surface of the bin body, and a telephone is arranged on the side surface of the liquid crystal touch display screen; an inlet is formed in the circumferential surface of the cabin body, a sealing strip is fixedly connected to the interior of the inlet, a sliding rail is arranged in the cabin body, a transparent window is slidably connected to the side face of the sliding rail, a high-grade sound box is arranged in the cabin body, and a cushion is fixedly connected to the interior of the cabin body. Through mutual cooperation of the cabin body, the liquid crystal touch display screen, the advanced sound equipment and other components, and through integration of environment regulation and control, mobile positioning, sealed visualization and acoustic auxiliary functions, a customizable, movable, private and comfortable independent sleep environment is provided for a user, and sleep quality and relaxation effect are effectively assisted to be improved.

The invention provides a saussurea involucrate patch for preventing and treating cold in uterus, dysmenorrhea and gynecological reproductive inflammation and a preparation method of the saussurea involucrate patch, and belongs to the technical field of gynecological nursing. The saussurea involucrate patch is prepared from 14 traditional Chinese medicine active ingredients including 10-25 parts of saussurea involucrate extract, 5-20 parts of folium artemisiae argyi extract, 1-5 parts of saffron crocus and the like, and an azone transdermal enhancer and a nano-scale montmorillonite adsorbent are supplemented. The preparation process adopts a differential extraction technology, firstly, medicinal materials such as astragalus membranaceus are crushed and then subjected to water extraction and alcohol precipitation, and then the medicinal materials are mixed with volatile components such as saffron crocus to prepare the core body. Animal experiments show that the saussurea involucrata paste can significantly reduce the inflammatory factor level and shorten the duration of dysmenorrhea, and has no skin irritation reaction. The traditional Chinese medicine composition achieves the effects of warming channels, dispelling cold, resisting inflammation and inhibiting bacteria through the synergistic effect of multiple components, and is suitable for conditioning cold in uterus and adjuvant therapy of gynecological inflammation.

The invention relates to the technical field of biological medicine, in particular to biodegradable magnesium sustained-release hydrogel, a preparation method thereof and application of the biodegradable magnesium sustained-release hydrogel in preparation of tumor postoperative adjuvant therapy products. The hydrogel is prepared by taking carboxymethyl chitosan and sodium alginate as matrixes, loading 1.2-9g of metal magnesium powder, mixing, adjusting pH and fumigating and cross-linking with glacial acetic acid, and a three-dimensional network of the hydrogel can realize continuous and controllable release of magnesium ions. According to the invention, the dual functions of promoting wound healing and removing residual tumor cells are realized: magnesium ions are used as healing-promoting enzyme cofactors to accelerate wound repair, and meanwhile, oxidative stress is induced to play an anti-tumor role by disturbing tumor cell iron metabolism; different release rates can be realized by regulating and controlling the loading amount of the magnesium powder, and different tumor postoperative treatment requirements are met. The hydrogel is excellent in biocompatibility, can be completely degraded, is suitable for postoperative adjuvant therapy of solid tumors such as melanoma and breast cancer, can reduce systemic toxic and side effects and tumor drug resistance risks, and is large in clinical transformation potential.

The invention discloses a rehabilitation training robot for leg rehabilitation adjuvant therapy in the psychiatry department, and particularly relates to the technical field of medical instruments.The rehabilitation training robot comprises two symmetrical first mechanical arm structures, the tops of the first mechanical arm structures are fixedly connected with second mechanical arm structures, and the tops of the two second mechanical arm structures are fixedly connected with a fixing structure; through cooperation of the first mechanical arm structure and the second mechanical arm structure, legs of a psychiatric patient can be massaged while the psychiatric patient receives rehabilitation training, so that the rehabilitation training effect is improved, acceleration of the rehabilitation process of the patient is promoted, through the fixing structure and the supporting structure, the adaptability and stability of the equipment in different environments are ensured, and the practicability is high. Rehabilitation training can be carried out on various occasions, meanwhile, the body and arms of a patient can be fixed, safety in the rehabilitation training process is ensured, the head and the neck of the patient are supported, and rehabilitation training is more comfortable.