338 results about "Adjuvant therapy" patented technology

The invention provides an expectoration auxiliary control method and device. The method comprises the steps that audio signals of breathing sounds and cough sounds at multiple positions of the chest of a patient are collected through an audio sensor array, and a standardized audio feature data set is obtained through noise reduction, segmentation and feature extraction; a dynamic weighted graph model is constructed, and a random edge sampling algorithm and a parallel batch processing dynamic algorithm are combined to analyze and obtain a sputum viscosity index and a sputum distribution position map; based on the result, mapping the vibration parameter space into an unweighted disk diagram, and obtaining a personalized vibration treatment scheme by using a shortest path algorithm; in combination with the real-time breathing cycle of the patient, working parameters of the sound wave vibrator and the negative pressure suction device are synchronously controlled, and a coordinated and consistent multi-mode treatment execution instruction is obtained; and collecting real-time feedback data in treatment, and dynamically adjusting working parameters through reinforcement learning to obtain an optimized expectoration adjuvant therapy scheme. Intelligent adjustment can be achieved based on the real-time breathing state and sputum characteristics of the patient, the expectoration efficiency is improved, and discomfort of the patient is reduced.

The invention discloses a multifunctional leg sleeve for auxiliary treatment of lower limb lymphedema, which comprises a leg sleeve body, a pressure sensing unit, a temperature and humidity sensing unit, an air bag pressure unit, a heating unit, an electrical stimulation unit, an impedance measuring unit and a portable force-electricity-heat cooperative intervention controller, the leg sleeve is characterized in that the pressure sensor and the temperature and humidity sensor monitor internal environment parameters of the leg sleeve body, drive the air bag pressure unit to perform self-adaptive pressurization, and drive the heating element and the electrical stimulation electrode to perform intelligent heating medicine application and muscle stimulation at the same time; the main control unit is driven to adjust the pressure, the temperature and the stimulation intensity of the air bag pressurizing unit, the heating unit and the electrical stimulation unit; in the wearing period, the device uploads data to a mobile phone and a cloud server terminal for data analysis, optimal pressure, temperature and electrical stimulation regulation prescriptions are provided for a user, and a good treatment effect is achieved.

The discovery and application of immune checkpoint inhibitors (ICI) have significantly promoted cancer treatment. However, the response rate is still low in gastrointestinal (GI) cancers. To explore novel adjuvant treatment options, we performed fecal microbiota transplantation (FMT) of healthy donors on 10 GI cancer patients with resistance to anti-PD-(L) 1 treatment. The combination of FMT and anti-PD1 treatment was well tolerated and no serious adverse reaction was observed. Two out of 10 patients restored clinical responsiveness to anti-PD1 after FMT. Clinical benefits were shown to be associated with better colonization of co-occurred immunogenic microbes from donors, alongside activated immune status reflected by the peripheral immune cell population. Moreover, we identified microbial signatures of ICI responsiveness and validated in an independent cohort. Our study demonstrates the feasibility of FMT as a potential adjuvant therapy for ICI irresponsive GI cancer patients and laid a foundation for LBP / consortia development to enhance ICI efficacy.

The invention discloses injectable hydrogel for photo-thermal adjuvant therapy of periodontitis and a preparation method, and belongs to the technical field of high polymer material preparation, the preparation method comprises the following steps: reacting MXene dispersion liquid with epigallocatechin gallate and MgSO4; then sequentially carrying out ultrasonic treatment, centrifugation, washing and freeze-drying to obtain a multifunctional nanosheet MP-Mg; adding the multifunctional nanosheet MP-Mg into an oxidized gellan gum aqueous solution, and carrying out a mixed reaction to obtain a solution A; mixing the quaternary ammonium salt chitosan aqueous solution and the carboxymethyl chitosan aqueous solution in equal volume, and reacting to obtain a solution B; and mixing the solution A and the solution B in equal volume for reaction. The hydrogel prepared by the preparation method disclosed by the invention has injectability, photo-thermal responsiveness, biological membrane penetrability, synergistic antibacterial property and long-acting anti-inflammatory property, and an innovative and practical photo-thermal adjuvant therapy platform is provided for clinical treatment of periodontitis.

The invention provides clinical gastrointestinal decompression equipment for the digestive system department, and belongs to the technical field of adjuvant therapy. Comprising a mounting mechanism; a connecting arm is fixedly connected to the front face of the mounting mechanism, a power mechanism is mounted on the side, away from the mounting mechanism, of the connecting arm through bolts, and a rail frame is fixedly mounted on the side, away from the mounting mechanism, of the power mechanism. Through the arrangement, the equipment can be installed on the side edge of a sickbed during use, can adapt to different occasions, can adjust the height to meet the requirements of different patients, realizes the transverse and longitudinal synchronous displacement of the massage mechanism on the abdomen of the patient through the motor driving of the power and linkage mechanism, is large in massage range and excellent in massage effect, can replace manual massage, is not influenced by the external environment, and is suitable for popularization and application. The massage decompression mechanism can be used for hot compress massage, the temperature can be adjusted, the pressure of the gastrointestinal tract is further relieved, and better treatment experience is brought to a patient.

The invention relates to the technical field of rehabilitation assistance, in particular to an intelligent breathing assistance system for lung rehabilitation, comprising: a breathing part, the breathing part comprising a breathing cylinder, the breathing cylinder comprising a fixed cylinder and a folding cylinder, the fixed cylinder being internally provided with an auxiliary assembly; the wearing part comprises a chest cover and an abdomen cover, a connecting channel and a vibration channel are formed in the chest cover, an air bag is embedded in the abdomen cover, and a vibration phlegm eliminating assembly is arranged in the vibration channel; the thoracico-abdominal movement mode recognition unit is used for detecting a breathing mode of a user; the lung function detection unit is used for calculating and detecting the tidal volume of a user; the personalized training control unit is used for adjusting breathing resistance according to the tidal volume and breathing modes, according to different breathing modes of users, the breathing assisting force is adjusted through kinetic energy of gas exhaled by the users, key parameters such as the tidal volume and the recovery condition are monitored in real time, the lung rehabilitation effect is further improved, and the lung rehabilitation effect is improved. And more accurate and effective breathing adjuvant therapy is realized.

The invention provides a bifidobacterium longum subsp. Longum aFMT-103 strain, which is classified and named as Bifidobacterium longum subsp. Longum, is preserved in Guangdong Microbial Culture Collection Center, and has a preservation number of GDMCC No: 65181. The invention also provides a preparation method of the bifidobacterium longum subsp. Longum aFMT-103 strain. The invention further provides a microbial preparation containing the aFMT-103 bacterial strain. In addition, the invention also provides an application of the strain or the microbial preparation in preparation of an anti-depression product, and also provides an anti-depression product. The bifidobacterium longum subsp. Longum aFMT-103 strain has the advantages that the bifidobacterium longum subsp. Longum aFMT-103 strain is separated from the faeces of healthy adults; the strain has a remarkable anti-depression effect, can be used for preparing a preparation for resisting depression symptoms, and is of great significance in prevention and adjuvant therapy of depression.

The invention belongs to the technical field of microorganisms, and particularly relates to application of bifidobacterium longum in preparation of products for prevention, treatment and / or adjuvant treatment of pneumonia. The preservation number of the bifidobacterium longum is GDMCC No: 65969, and the bifidobacterium longum can improve the body weight decrease trend of a pneumonia mouse and reduce the lung visceral organ index of LPS increase; the content of pro-inflammatory factors such as IL-1beta, TNF-alpha and IL-6 in serum is remarkably reduced, mRNA expression of inflammation-related genes such as COX-2, IFN-gamma and TNF-alpha in lung tissue is reduced, and dose dependence is achieved; meanwhile, alveolar structure damage and inflammatory cell infiltration of mouse lung tissue are relieved, and lung tissue pathological damage is repaired. The strain can be used as a core component for developing pneumonia prevention or adjuvant therapy related products, provides a novel microbial intervention means for pneumonia prevention and treatment, and has important application value.

The invention belongs to the field of nano-medicine and traditional Chinese medicine, and particularly discloses an antioxidant nano-material based on self-assembly of traditional Chinese medicine and copper ions and a preparation method thereof.The nano-material is prepared from BPCu nano-particles formed by self-assembly of berberine and procyanidine B2 under induction of the copper ions, the BPCu nano-particles are further subjected to surface modification through polyvinylpyrrolidone, and the antioxidant nano-material is prepared. And the stably dispersed PVP-coated BPCu nano structure is obtained. The material is small in particle size, uniform in distribution, good in water solubility and storage stability, excellent in free radical scavenging capacity and catalase-like activity and suitable for adjuvant therapy of oxidative stress related diseases, and the preparation method is easy and convenient to operate, does not need an organic solvent and has good industrialization and disease treatment potential.

The embodiment of the invention provides a hemodialysis fatigue patient-oriented health monitoring and propaganda treatment system, which comprises a cloud server and a first communication device, the patient holds the first communication device, and the cloud server comprises a health data collection module used for obtaining subjective health data and objective health data of the patient; the objective health recognition module is used for determining a first health state of the patient according to the objective health data; the subjective health recognition module is used for recognizing emotion information of the patient according to the objective health data; the reminding propaganda and education module is used for determining a pushing time point according to the living habits of the patient, the first health state and a preset treatment scheme, and pushing treatment reminding and health propaganda and education data to the first communication equipment at the pushing time point in combination with the emotion information of the patient; according to the system provided by the invention, an omnibearing and intelligent health management and adjuvant therapy platform is provided, help can be provided for the patient physiologically and psychologically at the same time, and the compliance of the patient to treatment is improved.

The utility model belongs to the technical field of medical equipment, and provides a medical bed for adjuvant therapy, which comprises a base, a bed board component and a lifting mechanism, and the lifting mechanism is used for connecting the base with the bed board component and driving the bed board component to lift; the lifting mechanism comprises at least three lifting pieces which are distributed in an axial symmetry mode with the gravity center of the medical bed as the center. The bed board assembly comprises a bed board supporting frame, the bed board supporting frame comprises a plurality of pieces of angle aluminum, a frame structure is formed through the multiple pieces of angle aluminum, and at least one piece of angle aluminum is used for providing a horizontal sliding rail. The medical bed is simple in structure, high in structural reliability and light in product weight, manufacturing, transporting and installing processes can be simplified, the transporting space requirement and the installing position bearing requirement for a user are lowered, and the acceptability of the user is improved.

The invention discloses an antibacterial dressing based on gallic acid-copper coated gamma-polyglutamic acid and a preparation method and application thereof, and belongs to the technical field of biomedicines.The preparation method comprises the steps that gallic acid and copper chloride dihydrate are dissolved in pure water according to the mass ratio of 3: 1, and stirring is conducted to form a solution I; stirring and reacting the solution I at 40 DEG C for 24 hours, centrifuging, collecting precipitate, washing with pure water, and freeze-drying to obtain gallic acid-copper nanoparticles; the gallic acid-copper nanoparticles and gamma-polyglutamic acid powder are mixed and dissolved in pure water according to the mass ratio of 3: 20, and after freeze drying, gallic acid-copper coated gamma-polyglutamic acid hydrogel powder is obtained. The gallic acid-copper coated gamma-polyglutamic acid hydrogel powder disclosed by the invention can absorb exudate near a wound and is subjected to in-situ gelation to form a hydration layer, so that damage to newborn tissues caused by frequent dressing replacement is avoided; it is verified that the healing promoting effect of the hydrogel can be remarkably enhanced through blue light adjuvant therapy, and the healing speed of infected wounds is remarkably increased.

The invention belongs to the technical field of microorganisms, and particularly relates to application of bifidobacterium longum in improving immunity and preparing products for preventing, treating and / or assisting in treating rhinitis. The preservation number of the bifidobacterium longum is GDMCC No: 65969, and the bifidobacterium longum can reduce the levels of MDA and NO in serum of mice and improve the activity of SOD and CAT and the content of GSH so as to relieve oxidative stress injury; inflammatory cell infiltration of nasal mucosa is reduced, and lung tissue inflammatory mediator level and inflammation-related gene expression are reduced to inhibit inflammation; th1 / Th2 immune balance is regulated, Th2 type cytokines are reduced, Th1 type cytokines are increased, and the high-dosage effect is close to that of loratadine. The strain has a treatment effect on allergic rhinitis through multiple mechanisms, and a new choice is provided for treatment of the strain.

Disclosed are multi-peptide compositions and / or methods of use of the multi-peptide compositions for patients with resected (or definitively treated) high-risk uveal melanoma. Pharmaceutically acceptable embodiments administered to patients may raise an immune system response against uveal melanoma cells, leading to a decrease in uveal melanoma cell number. Further embodiments may take the form of an adjuvant therapy or a neoadjuvant therapy, as monotherapy or in combination with other therapies.

The invention discloses a bacterial strain with an anti-tumor effect and application of the bacterial strain, the bacterial strain is Lactobacillus paracasei Biohalo 27, the bacterial strain is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number is CGMCC NO.34917; the preservation time is June 16, 2025; the screened strain with the anti-tumor effect has the effects of inhibiting proliferation and migration of rectal cancer cells and breast cancer cells, retarding the cell cycle and promoting cell apoptosis, so that the anti-tumor purpose is achieved, and the strain can be used as a potential application value of probiotic adjuvant therapy.

The invention relates to application of lactobacillus helveticus HH-LPH17 in preparation of medicine for assisting in relieving inflammatory bowel diseases and relates to the technical field of probiotic compositions.The probiotic composition for treating the inflammatory bowel diseases comprises, by weight, 10 parts to 80 parts of lactobacillus johnsonii LBJ 456, 10 parts to 60 parts of lactobacillus helveticus HH-LPH17, 10 parts to 60 parts of lactobacillus acidophilus HH-LA26 and 10 parts to 60 parts of bifidobacterium longum HH-BL18. The composition comprises the following components in parts by weight: 10-60 parts of bifidobacterium bifidum HH-BB27 and 10-60 parts of bifidobacterium longum subspecies infantis HH-BI27. According to the probiotic composition for treating the inflammatory bowel disease, probiotic strains with specific effects are screened out, the combination proportion of the probiotic strains is optimized, the probiotic composition for treating the inflammatory bowel disease is prepared, and a novel safe and effective adjuvant therapy method is provided for treatment of the inflammatory bowel disease.

The invention relates to a probiotic composition for treating rheumatoid arthritis and application thereof, and relates to the technical field of probiotic compositions.The probiotic composition for treating rheumatoid arthritis is prepared from, by weight, 10-40 parts of lactobacillus johnsonii LBJ 456, 10-30 parts of lactobacillus helveticus HH-LPH17 and 10-30 parts of lactobacillus acidophilus HH-LA26. The bifidobacterium longum subsp. Longum HH-BL18, the bifidobacterium bifidum HH-BB27 and the bifidobacterium longum subsp. Infantis HH-BI27 are prepared from the following raw materials in parts by weight: 10 to 40 parts of bifidobacterium longum subsp. Probiotic strains with specific effects are screened out, the combination proportion of the probiotic strains is optimized, the probiotic composition for treating rheumatoid arthritis is prepared, and a novel safe and effective adjuvant therapy method is provided for treatment of RA.

The invention belongs to the technical field of microorganisms, and particularly discloses lactobacillus paracasei and application thereof, the lactobacillus paracasei is named as lactobacillus paracasei Jlus66, the lactobacillus paracasei is preserved in China General Microbiological Culture Collection Center on March 31, 2021, the preservation address is No.3, No.1 Yard, Beichen West Road, Chaoyang District, Beijing, and the preservation number is CGMCC No.22101. The lactobacillus paracasei is named as lactobacillus paracasei Jlus66. The lactobacillus paracasei Jlus66 has the obvious beneficial effects in the treatment of the alopecia areata, and the obvious beneficial effects comprise the immune regulation, the anti-oxidation and anti-inflammatory effects and the optimization of the intestinal tract-skin axis. In addition, the medicine is high in safety and small in side effect, so that the medicine becomes a promising adjuvant therapy means.

The invention relates to a dynamic intelligent fixing device for lower limb rehabilitation, which belongs to the technical field of medical instruments and comprises a dynamically adjustable leg supporting structure, a self-adaptive foot fixing device, a multi-modal stimulation system, a double-shaft linkage movement mechanism and an intelligent regulation and control system. The dynamic adjusting structure and the self-adaptive fixing device can adapt to different leg circumferences, foot types and joint motion ranges, and comfortable fixing and standard movement of a patient are guaranteed; the multi-mode stimulation system is combined with mechanical movement, pneumatic massage and myoelectricity stimulation to synergistically promote blood circulation of the lower limbs; the intelligent regulation and control system collects multi-dimensional physiological data in real time and dynamically optimizes motion parameters and stimulation intensity. The device solves the problems that an existing device is poor in adaptability, single in stimulation, lagged in regulation and control and the like, individualized precise adjuvant therapy is achieved, the lower limb rehabilitation effect and clinical benefits of postoperative lower limb fixation and VTE prevention are effectively improved, and meanwhile the operation complexity of medical staff is reduced.

The invention relates to the technical field of medical instruments, in particular to a constipation adjuvant therapy appliance and a using method thereof.The constipation adjuvant therapy appliance comprises an insertion tube, a vibration sleeve is arranged at the inner end of the insertion tube, and a vibration motor is arranged in the vibration sleeve; the outer end of the insertion pipe is connected with a medium pipeline used for inputting or outputting a medium into or out of a pipe cavity of the insertion pipe. A plurality of protruding blocks are arranged on the pipe wall of the outer side of the insertion pipe. Through mechanical pressure generated by expansion of the insertion tube and the adjusting cavity of the insertion tube and local stimulation of the outer side protruding block on the rectum wall, low-frequency vibration of the vibration motor in the vibration sleeve is combined, a rectum wall mechanical receptor and a nerve conduction path are cooperatively activated in a multi-mode mode, defecation reflex is triggered, and therefore targeted intervention on defecation reflex disorder of a constipation patient is achieved. The defect that a traditional therapy does not touch a neural mechanism is overcome, and a comprehensive solution from physiological reflex activation to mechanical power enhancement is provided for constipation treatment.

The invention provides an airway stent, and relates to the technical field of airway stents. Ozone gas is contained in the storage bottle body, the internal space of the storage bottle body is in a circular ring shape, and a sealing bottle cap is buckled on the top of the storage bottle body; the memory metal support is located in the annular space in the storage bottle body. A rubber sealing ring is installed in the sealing bottle cap, the storage bottle body is sleeved with a movable sleeve shell, and the top of the movable sleeve shell is connected with the sealing bottle cap. A spring is connected into the movable sleeve shell and connected with the storage bottle body. When the memory metal stent is placed in the airway of a patient, the melt degradation film is degraded by body fluid, the inhibition medicine is slowly released from the slow release micropores, and granulation hyperplasia in the airway is inhibited for a long time. The problems that an existing medical airway stent mostly adopts a coating film drug-containing mode for adjuvant therapy, due to the fact that an outer side coating film is thin, the drug content is small, the drug contained in the coating film can be completely released in a short time, and the effect is not long enough are solved.

The invention provides a smearing sustained-release preparation and a preparation method and application thereof, the smearing sustained-release preparation comprises a chemotherapeutic drug component, an immune drug component and a sustained-release auxiliary material, and the smearing sustained-release preparation is in a transparent flowable sol shape. The sustained release preparation disclosed by the invention can be smeared and applied to a focus part in situ after a tumor operation. The application effect comprises the following steps: filling the treatment window period of the traditional postoperative adjuvant chemotherapy, and improving the local drug concentration of the focus through in-situ local slow release of the drug, thereby effectively removing residual tumor tissues and reducing the systemic toxicity of drug treatment; the metastasis and recurrence rate of tumors are further inhibited through the synergistic combined effect of chemotherapy-immune drugs in the preparation. The advantages show that the smearing sustained-release preparation provided by the invention has huge clinical potential in the aspect of tumor treatment.

The invention provides an intelligent physical sign detection and auxiliary decision making system based on data fusion. The system is applied to the technical field of physical sign detection and adjuvant therapy, and comprises an acquisition and preprocessing module used for acquiring and preprocessing multi-modal human body physical sign data of a patient; the model construction and optimization module is used for constructing a data feature extraction and layer strategy combined with a random forest and a ReliefF algorithm to carry out model training, and predicting to obtain a sign detection result; the stimulating electrode adjusting module is used for dynamically adjusting the intensity, the frequency and the position of a stimulating electrode by adopting a feedback mechanism of a self-adaptive proportional-integral-differential control algorithm according to the predicted physical sign detection result; and the data visualization module is used for presenting the multi-modal human body sign data, the sign detection result and the electrode stimulation real-time condition in real time in a data visualization mode, and assisting doctors in operation and decision making. The accuracy, practicability and scientificity of the medical health detection system are improved.

The invention provides a breast cancer adjuvant therapy pathology complete remission prediction method and electronic device.The breast cancer adjuvant therapy pathology complete remission prediction method comprises the steps that at the first stage, based on multi-time-point and multi-parameter MRI images of a patient before and after adjuvant therapy, the breast cancer adjuvant therapy pathology complete remission prediction result is obtained; training an image feature encoder with a tumor dynamic change identification capability through a dynamic supervision pre-training mode; and a second stage of constructing a multi-modal deep fusion network based on the image feature encoder to integrate the image features, radiomics features and clinical pathological features of the patient, and outputting a prediction result of complete pathology remission, the radiomics features being extracted from the MRI image. And the purposes of high precision and strong generalization capability are achieved.

The invention relates to the technical field of cervical vertebra adjuvant therapy, in particular to a pain department cervical vertebra adjuvant therapy device which comprises a base, a connecting seat mounted on the base and a seat mounted on the connecting seat, a plurality of sliding ventilation grooves are symmetrically formed in the seat, and a headrest is mounted on the seat. A neck massage head is arranged at the position, below the headrest, of the seat, a neck elastic assembly is connected to the rear portion of the neck massage head, a transmission mechanism is arranged at the bottom of the seat, through the linkage design of the pedal driving mechanism and the transmission mechanism, when a patient actively steps on the pedal plates, precise massage is conducted on related acupuncture points, and meanwhile, the massage effect is good. The body posture can be adjusted through the leg lifting action, the neck can be better attached to the neck massage head, the composite curative effect of active movement and passive massage is formed, the design breaks through the limitation of traditional equipment and passive massage of a single part, and the comprehensiveness and durability of treatment are remarkably improved.

This invention discloses a multi-target synergistic anti-liver cancer medical food granule and its preparation method. The granule uses medicinal and edible homologous foods and novel resource foods as raw materials, and is composed of curcumin extract, esterified fat-soluble EGCG, Moringa leaf powder, yeast β-glucan, Astragalus extract, Schisandra extract, Salvia miltiorrhiza extract, Poria cocos powder, resistant dextrin, and erythritol in a specific ratio to construct a three-dimensional synergistic system of "direct killing-immune regulation-liver protection," which can induce ferroptosis in liver cancer cells, inhibit protective autophagy, activate the body's immunity, and protect liver cells. This invention employs directional extraction, multi-layer coating, and high-pressure fusion granulation technology. Nanoparticle liposome encapsulation, esterification modification, and pH-responsive enteric coating improve the stability and bioavailability of the components, solving the problems of poor water solubility, low absorption, and easy degradation of natural active ingredients. The granule has clear efficacy, high safety, and stable process, and can be used as a medical food for adjuvant therapy and nutritional support during the recovery period of liver cancer.

The invention relates to a compound bath product containing lincomycin and vitamin B6 and a preparation method of the compound bath product, and relates to the technical field of daily chemical products. Aiming at the problems of single effect, low component residence rate, poor medical component adaptability and the like of a traditional bath product in acne care, a triple synergistic formula of lincomycin (antibacterial), vitamin B6 (oil control) and glycyrrhizic acid / glycosylglycerol (anti-inflammatory) is innovatively constructed, and the adjuvant therapy effect on mild acne is effectively improved through clinical verification; a pH / temperature dual-response microcapsule wrapping technology is developed, so that the transdermal absorption rate of active ingredients is effectively improved, and the washing loss rate is less than or equal to 15%; the traditional Chinese medicine composition breaks through the limitation of medical cream types, is matched with bath carriers such as facial cleanser, shampoo, soap, shower gel and the like, and realizes daily application of acne care components. The product disclosed by the invention has the advantages of controlling oil within 6 hours and reducing the skin irritation by 42%, and fills up the technical blank of washing and caring products in medicine-grade efficacy and use convenience.

The utility model discloses a breathing machine humidifying atomizer, relates to atomizer field, including atomizer and airway tube, atomizer includes equipment casing and heating atomization structure, equipment casing is hollow inside, equipment casing inside is fixedly connected with the heating atomization structure, the inner wall of outer casing bottom is fixedly connected with air intake base, and the inner wall of outer casing bottom is fixedly connected with the air intake base. The utility model provides a humidifying atomizer of a breathing machine. An air guide pipe is fixedly inserted into the top end of the atomizer. The heating and atomizing structure is fixed in an equipment shell of the atomizer and plays a role in heating and humidifying oxygen and water mist in the atomizer; the movable top cover is connected to the top end of an atomizer shell of the heating atomization structure in a sliding mode and plays a role in controlling spraying of oxygen and water mist on the heating atomization structure. According to the respirator atomizer, water and oxygen can be heated and humidified through the built-in heating and atomizing structure, the heating temperature can be controlled, and the respirator atomizer is matched with medical staff to conduct adjuvant therapy on a patient.

The invention belongs to the cross field of functional food processing and diabetes adjuvant therapy, and discloses a high-activity sugarcane hypoglycemic beverage and a preparation method of a prebiotic additive thereof. The method comprises the steps of sugarcane raw material separation, supercritical CO2 extraction of active components of sugarcane peel (the temperature is 35-45 DEG C, the pressure is 20-30 MPa, and the time is 60 + / -10 min), enzymolysis synergistic squeezing (compound enzymes comprise glucose isomerase, cellulase and pectinase), graded membrane separation desugaring and active compounding (the sugar degree is adjusted to 6.0 + / -0.5 degree Bx) and the like, and the blood glucose reducing beverage containing 15-18 mg / L of octacosanol, 105-120 mg / L of sugarcane polyphenol and 5.5-6.5 degree Bx is prepared. Meanwhile, the membrane separation trapped fluid is processed into the prebiotic additive of which the water-soluble dietary fiber is greater than or equal to 65% and the prebiotic activity index is greater than or equal to 2.8. The invention solves the problems of active ingredient loss, inaccurate sugar degree regulation and control and the like in the prior art, and is suitable for the development of functional foods for adjuvant therapy of diabetes mellitus.

The present disclosure provides methods for treating, reducing the severity of, inhibiting the growth of a tumor, or inducing necrosis of a tumor, wherein the method includes selecting a patient with cancer (e.g., liver cancer, lung cancer, or head and neck cancer) in need thereof and administering to the patient a neoadjuvant therapy comprising a therapeutically effective amount of a programmed death 1 (PD-1) inhibitor (e.g., cemiplimab or a bioequivalent thereof) in combination with radiation therapy (e.g., SBRT) or an anti-LAG-3 antibody (e.g., fianlimab) followed by surgical resection, and optional administration of a programmed death 1 (PD-1) inhibitor (e.g., cemiplimab or a bioequivalent thereof) as post-surgery adjuvant therapy. In certain embodiments, the cancer is liver cancer, such as hepatocellular carcinoma (HCC).