25 results about "Renal replacement therapy" patented technology

The utility model provides a bioreactor device for replacing the function of a renal tubule, the bioreactor device is placed in a cell culture incubator, the bioreactor device comprises a fixed frame and a chip, the chip is arranged on the fixed frame, and a vein-imitated renal tubule structure is formed in the chip; openings in the two ends of the flow channel are respectively a liquid inlet and a liquid outlet; the inner diameter of the main flow channel is larger than that of the micro flow channel; wherein the inner diameter of the main flow channel and the inner diameter of the micro flow channel of the chip are both within the pipe diameter range of the physiological renal tubule; a human renal tubular epithelial cell suspension enters the vein-imitating flow channel from the liquid inlet and is attached to the inner wall of the vein-imitating flow channel. Therefore, the structure of the renal tubule is reflected in a more bionic and more reasonable manner, the physiological environment of the renal tubule can be simulated more accurately, a new design thought and method are provided for a renal tubule bioreactor device in a bioartificial kidney, the difficulty in the field of kidney replacement therapy is expected to be solved, and the life quality of patients with end-stage renal failure due to nephropathy is improved.

The invention relates to medicine, in particular to infusion therapy, kidney replacement therapy and gravitational blood therapy. The Y-shaped connecting pipe is designed in the form of a Y-shaped tubular pipeline connector with a branch pipe connected at the tail end, the branch pipe is connected to the ends of the pipelines, and at least one clamping and closing device is mounted on each pipeline. A port with a female joint is arranged at the end part of one pipeline, a connector with a male joint is arranged at the end part of the other pipeline, two pipelines can be connected to a catheter port or a puncture needle positioned at the access point of two blood vessels, and one pipeline can be connected to an extracorporeal circulation loop. The present invention can combine multiple passages into a single outflow and a single inflow and connect it to an extracorporeal circuit while also allowing for varying the linear and volumetric flow rate of the delivered liquid, reducing the resistance of the liquid, and automatically regulating the pressure in the pipeline circuit through a second passage point of a single system.

The present invention provides methods relating to the discovery of olfactomedin 4 (OLFM4) as a biomarker for acute kidney injury (AKI) and need for renal replacement therapy, and further as a biomarker for responsiveness to the furosemide stress test (FST). The methods described here are useful in clinical decision support and personalized therapy for AKI, as well as for clinical trial design.

An implantable renal replacement therapy device may include: a first catheter configured to be inserted into a blood vessel in a subject's body; a pump in fluid communication with the first catheter, the pump is configured to pump subject's blood from the blood vessel; a filter in fluid communication with the pump, the filter is configured to: receive the subject's blood from the pump, and filter the received blood to provide a filtered blood and a filtrate liquid, wherein the filter is in fluid communication with the first catheter to cause an outflow of the filtered blood from the filter to the blood vessel; and a second catheter in fluid communication with the filter and configured to be inserted into an urinary bladder in the subject's body to cause an outflow of the filtrate liquid from the filter to the urinary bladder.

A renal replacement apparatus (100), having a hemofilter (108); an extracorporeal blood circuit (102) configured to communicate blood from a patient (104), through the hemofilter, and back to the patient; and a flow measuring device (150) configured to measure at least one blood flow property as the blood is leaving the hemofilter and before the blood returns to the patient at a flow measuring device location (152), wherein the flow measuring device comprises at least one of a viscometer and a rheometer. Alternately, or in addition, the renal replacement apparatus may include thermomodulator system (222) including at least one thermomodulator configured to selectively heat and cool the blood in the extracorporeal blood circuit. The renal replacement apparatus (100) may have a controller (160). The controller may use artificial intelligence. Other embodiments are described herein.

An implantable renal replacement therapy device may include: a first catheter configured to be inserted into a blood vessel in a subject's body; a pump in fluid communication with the first catheter, the pump is configured to pump subject's blood from the blood vessel; a filter in fluid communication with the pump, the filter is configured to: receive the subject's blood from the pump, and filter the received blood to provide a filtered blood and a filtrate liquid, wherein the filter is in fluid communication with the first catheter to cause an outflow of the filtered blood from the filter to the blood vessel; and a second catheter in fluid communication with the filter and configured to be inserted into an urinary bladder in the subject's body to cause an outflow of the filtrate liquid from the filter to the urinary bladder.

The present invention discloses an artificial intelligence-based odor feedback method, which relates to the technical field of odor feedback. The method comprises the following steps: dynamically calculating the clearance rate of odor components in patients with liver and kidney dysfunction by using a CYP2A6 enzyme kinetic model and a renal replacement therapy adsorption equation; combining the liver and kidney metabolic overload threshold constraints of a contraindication mapping table to reduce toxicity risks and solve the metabolic uncontrollability problem of traditional methods; designing a pulse release waveform based on an olfactory sensitivity attenuation model, coupling reverse airflow flushing, shortening the receptor recovery period and the EEG response latency, thereby overcoming the desensitization effect caused by sustained release.

The group of inventions relates to medicine, and more particularly to devices for introducing drugs into the human body and withdrawing various media from the human body, and even more particularly to dialysis systems, as well as to catheters with various channel arrangements or shapes for fluid media, and can be used in infusion therapy, renal replacement therapy and gravity-assisted blood treatment to optimize the withdrawal and return of infusion solutions, blood, blood components and preparations. The technical result of the claimed group of inventions is that of providing broader functional capabilities, consisting in efficiently realizing the possibility of joining several accesses both into a single outflow and into a single inflow, with inclusion into an extracorporeal circuit, while also permitting variation of the linear and volumetric flow rate of the transported fluid and a reduction in the resistance of said fluid, with the distribution of the pressure of the fluid and automatic regulation of the pressure in the tubing circuit by virtue of a second point of access via a single system, as well as reducing patient emergency situations accompanied by activation alarms in extracorporeal treatment apparatus. To achieve this technical result, an extracorporeal treatment system and method are proposed.

The invention discloses a system and method for evaluating the curative effect of RDN based on plasma rennin concentration change, the system comprises a baseline measurement module, a postoperative measurement module and a judgment module, the baseline measurement module is used for collecting an erect vein blood sample of a patient and measuring the baseline erect plasma rennin concentration of the patient on the day before the RDN operation; the postoperative measurement module is used for collecting a venous blood sample of a patient within 24 hours after the RDN operation is completed, and measuring the postoperative plasma rennin concentration of the patient; and the judgment module is used for calculating the change rate of the plasma renin concentration of the postoperative measurement module relative to the baseline measurement module, and comparing the change rate with a preset threshold value to judge whether the operation is effective or not. According to the invention, curative effect feedback can be provided within an extremely short time after an operation is finished, which is far earlier than blood pressure change after several months, and'gate advance 'of curative effect evaluation is realized. The invention provides an objective and quantitative standard (delta PRC%) based on blood biochemical indexes, and reduces the error of subjective judgment.

The present invention relates to the use of an alkaline phosphatase, in particular an improved alkaline phosphatase, such as RecAP, for preventing, treating, curing or ameliorating the symptoms of acute kidney injury on the basis of chronic kidney injury. The present application relates to alkaline phosphatase enzymes for use in methods of protecting renal function, shortening the duration of renal replacement therapy, maintaining creatinine clearance, and reducing the risk of death in a subject suffering from acute renal injury on the basis of chronic renal injury.

A system is configured to generate a medical fluid for renal replacement therapy by mixing fluids in-line. The system includes a first flow path (12), a second flow path (16), a first sensor (20) in the first flow path, and a second sensor (20 ') in the second flow path. The first sensor and the second sensor measure component-related parameters. The system is operable to deliver at least one of the fluids to the first sensor and the second sensor during a calibration phase and to determine a conversion function for converting between a first signal of the first sensor and a second signal of the second sensor during the calibration phase based on the first signal of the first sensor and the second signal of the second sensor. In a generation phase, the system is operable to control the at least one pump based on a converted measurement given by performing a conversion function on a measurement in the first signal from the first sensor.

A virtual assistant / chatbot to improve clinical workflow for home renal replacement therapies is disclosed herein. A virtual assistant / chatbot includes a user interface configured to enable a patient to engage in a virtual chat session by typing, speaking, or otherwise providing information regarding a patient request or issue related to their renal replacement therapy. The virtual assistant / chatbot also includes a server configured to provide logic to respond to the patient's requests. The logic defines a sequence of questions and answers for resolving patient queries. The sequence of assistant / chatbot questions and patient answers may be configured in a node arrangement such that certain patient answers / requests lead to additional questions for additional information from a patient. The virtual assistant / chatbot is configured to answer patient requests automatically or determine when the patient request is to be immediately addressed by a clinician or later through a phone call, text, or email communication.

Plasma electrolyte management system, methods, and apparatus for continuous renal replacement therapies (RRT) are disclosed. The example system, methods, and apparatus use one or more kinetic physiological models to calculate a current electrolyte rate of change in plasma sodium or other electrolytes based on current data for patient weight, input / output of water, sodium, and potassium (e.g., input / output of known infusions, dialysis, urine, blood loss, etc.) This input / output data is acquired through known data, such as infusion data, dialysis data, urine data, and blood loss data, which are typically stored to a patient's electronic medical record (“EMR”) as the data is generated / received. The use of available point-in-time input / output data to generate accurate electrolyte concentration estimations means that fewer (or none) blood tests are needed, thereby providing accurate electrolyte determinations without frequent burdensome blood analyses.

1. The name of the design product: waste liquid collection adapter pipe. 2. The use of the design product: for the matching medical consumables of continuous renal replacement therapy equipment. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective drawing.

The invention provides an ICU-AW risk prediction method fusing early activity quantity quantitative evaluation, and through analysis, it is found that age, kidney replacement therapy and propofol usage amount are independent risk factors of ICU-AW after departure, and the total amount of early activity in the first week after departure is an independent protection factor of the ICU-AW after departure and has good prediction value for the ICU-AW. Therefore, the early activity amount is taken as a predictive factor to be incorporated into the ICU-AW prediction model, so that the prediction efficiency of the model is improved, and the prediction precision and clinical practical application significance of the ICU-AW risk are improved. According to the method, an ICU-AW risk prediction model is constructed based on the verified ICU-AW risk influence factors, the ICU-AW diagnosis and treatment characteristics of the ICU patient are identified, and the corresponding ICU-AW occurrence rate after departure is predicted, so that accurate ICU-AW risk prediction is realized, and a hospital can conveniently quantify and report intervention measures on the ICU-AW movement of the ICU patient.

The invention relates to the technical field of medical instruments, in particular to a thrombus detection quantification and early warning system and method in the CRRT process, and the system comprises an infrared camera shooting function module, an artificial intelligence learning module, a thrombus detection alarm module and a cloud data management platform. The infrared camera module adopts a 760nm-1500nm multispectral infrared camera, continuously shoots CRRT in-vitro pipeline blood at a frame rate of more than or equal to 30fps, and eliminates temperature interference in combination with a constant temperature compensation technology; the artificial intelligence module realizes nano-scale thrombus recognition through thrombus sample training based on a convolutional neural network and an attention mechanism; and the detection alarm module realizes thrombus feature analysis, blood coagulation time prediction and multi-stage alarm through three-dimensional volume calculation and an LSTM time sequence model, and generates a personalized anticoagulation scheme. According to the system, early-stage accurate detection and real-time early warning of thrombus are achieved through multi-technology fusion, and clinical verification shows that the CRRT treatment safety can be remarkably improved.

1. Name of the designed product: Continuous blood purification equipment (RENUE-CRRT). 2. Use of the designed product: used for blood purification of patients. 3. Design points of the designed product: in shape. 4. Picture or photo best indicating the design points: perspective view.

The invention discloses a pipeline sealing performance testing device and method for continuous kidney replacement therapy. The pipeline sealing performance testing device comprises a pressurizing module, a measuring module, a vision module and a control module. The pressurizing module is used for outputting positive pressure gas or negative pressure gas; the measuring module comprises a measuring container, an air inlet unit and a clamping unit, the measuring container is used for storing liquid and containing a to-be-measured pipeline for measurement in the liquid, the air inlet unit comprises an air inlet pipeline and an air inlet control valve, the air inlet control valve is arranged on the air inlet pipeline, and the first end of the air inlet pipeline is used for being connected with an air inlet of the to-be-measured pipeline; the second end of the gas inlet pipeline is connected with the positive pressure gas outlet and the negative pressure gas outlet of the pressurization module at the same time, the clamping and closing unit is used for clamping and closing a to-be-detected pipeline for clamping and blocking, and the visual module is used for obtaining an image in the measuring container, conducting leakage analysis and then outputting detection data. According to the invention, rapid automatic detection of the tightness of the pipeline for continuous kidney replacement therapy is realized, and full-path detection and shunt detection can be switched.

A system of identifying an ultrafiltration rate in a renal replacement therapy device is provided, wherein the system includes a controller connected to a first flow sensor obtaining flow rate data from a blood withdrawal line and a second sensor obtaining flow rate data from a blood delivery line. The controller calibrates, such as matches, the first flow sensor and the second flow sensor from flow measurements during periods of known ultrafiltration by the renal replacement therapy device. The controller is further configured to perform periodic equalization of the flow sensors, at a known ultrafiltration rate during the treatment session. The controller can employ flow rate data from the calibrated or equalized first flow sensor and the second flow sensor to calculate an ultrafiltration rate of the renal replacement therapy device based on the measured blood flow into and out of the renal replacement therapy device. The calibration can be performed before, during, or after blood treatment in a treatment session.

The puncture catheter for kidney replacement therapy comprises a blood guiding tube, a blood returning tube, a first positioning guide wire and a second positioning guide wire, the blood guiding tube comprises a blood guiding main tube body and a blood guiding auxiliary tube body, the blood guiding auxiliary tube body is located in the blood guiding main tube body, the blood guiding main tube body is provided with a blood guiding end and a blood guiding exposed end, the side wall of the blood guiding end is provided with a side hole, and the side hole is communicated with the blood guiding auxiliary tube body. A blood guide opening is formed in the blood guide attached tube body and is exposed on the side hole; the blood return tube comprises a main blood return tube body and an auxiliary blood return tube body, the auxiliary blood return tube body is located in the main blood return tube body, the main blood return tube body is provided with a blood return end and a blood return exposed end, the blood return end is provided with a main hole, the auxiliary blood return tube body is provided with a blood return opening, and the blood return opening is exposed on the blood return end; the first positioning guide wire is positioned in the blood guide attached tube body; the second positioning guide wire is located in the blood return attached tube body, and whether the catheter has problems or not can be directly judged by checking the tail conditions of the first positioning guide wire and the second positioning guide wire.

This disclosure relates to the use of alkaline phosphatases, particularly improved alkaline phosphatases such as RecAP, for the prevention, treatment, cure, or improvement of symptoms of acute kidney injury in addition to chronic kidney injury. This application relates to alkaline phosphatases for use in a method to preserve renal function, shorten the duration of renal replacement therapy, preserve creatinine clearance, and reduce the risk of death in subjects having acute kidney injury in addition to chronic kidney injury.

The utility model discloses a medical instrument for extracorporeal membrane oxygenation and continuous kidney replacement therapy, and relates to the technical field of medical instruments, the medical instrument comprises an ECMO loop system and a CRRT loop system, the ECMO loop system comprises a pump front area, a pump rear membrane front area and a membrane rear area; a blood leading point of the CRRT loop system is connected to the membrane rear area, a blood returning point of the CRRT loop system is connected to the pump rear membrane front area, and a pressure reducing valve, a one-way valve, a CRRT sensor, a blood pump and a filter are sequentially arranged from the blood leading point to the blood returning point; the pressure reducing valve is used for reducing the pressure of a pipeline flowing from a blood leading point to one side of the blood returning point, and the one-way valve is used for one-way conduction of blood from the pressure reducing valve to one side of the CRRT sensor. The problem that treatment is interrupted due to the fact that a CRRT machine gives out an over-high pressure alarm due to the fact that the pressure difference between an ECMO loop system and a CRRT loop system is large is effectively solved.

A continuous kidney replacement therapy alarm device disclosed by the present invention comprises a clamping mechanism, the clamping mechanism comprises two fixing pieces, the two fixing pieces are connected to a turntable through a first adjusting mechanism, the lower end of the turntable is connected to a support frame through a second adjusting mechanism, and the support frame comprises a support frame. A supporting ring is fixedly welded to the supporting frame, clamping pieces are fixedly arranged at the two ends of the supporting ring, and a fixing mechanism is arranged at the lower end of the clamping mechanism. The first adjusting mechanism comprises a two-way screw rod, an adjusting groove is formed in the rotating disc, the two-way screw rod is rotationally connected into the adjusting groove, a moving block is connected to the two-way screw rod in a threaded mode, the fixing piece is welded to the moving block, and the continuous kidney replacement therapy alarm device can achieve alarm processing on blood clots and the like.

The application discloses a dialyzer blood leakage detection method and device in continuous renal replacement therapy, an electronic equipment and a storage medium, and relates to the technical field of dialyzer blood leakage detection. The method comprises the following steps: emitting light sources of four wave bands of blue light, green light, red light and infrared light through a light emitting module, and making the light sources of the four wave bands pass through a dialysate waste liquid pipe; acquiring signals corresponding to the light sources of the four wave bands after passing through the dialysate waste liquid pipe through a light source receiving module; sampling the signals acquired by the light source receiving module, and sending the sampling data to a processing module, so that the processing module acquires Bb, Gg, Rr, IRir, Bt, Gt, Rt and IRt, and the processing module calculates the blood concentration of the dialysate waste liquid through a BP neural network. According to the dialyzer blood leakage detection method in continuous renal replacement therapy, the blood concentration of the dialysate waste liquid can be accurately detected, and the false alarm phenomenon is reduced.

The application provides an integrated fixing frame for a continuous kidney replacement therapy pipeline, comprising: a fixing clamp; a mounting frame sleeved on the fixing clamp; a pipe clamp assembly fixedly installed on the mounting frame and used for mounting a treatment instrument; and a locking mechanism comprising an adjusting rod, an adjusting piece and a pressing ring, wherein the adjusting rod is installed on the mounting frame, the pressing ring is slidably installed on the inner side of the mounting frame, the adjusting rod can be rotated clockwise and counterclockwise, the pressing ring can be moved up and down by the adjusting piece, the pressing ring can exert pressure on the hinge of the fixing clamp when moving downward, the fixing clamp is provided with a slot, and the adjusting rod can be inserted into the slot when moving downward. The technical problem that the treatment pipeline may be subjected to continuous or instantaneous external force due to changes in the patient's body position, pulling by medical care operation or accidental hooking, and the fixing frame is difficult to resist such pulling only by the simple engagement of the elastic clamp and the mounting rod, and the fixing frame is prone to sliding, displacement and even falling off from the mounting rod as a whole can be solved.