4078results about "Dialysis systems" patented technology

A system, method, and article for delivering an antimicrobial agent into the lumen of a trans-dermal catheter are disclosed. In an embodiment, the system comprises an elongate member configured for insertion into a lumen of a catheter, and the elongate member containing an antimicrobial. An antimicrobial agent can be placed on an interior surface of a retaining ring.

The invention relates to the technical field of data monitoring and analysis, and discloses a hemodialysis care unit extracorporeal circulator monitoring method and system and a storage medium. The method comprises the steps that vital signs and identity features of a patient are collected, a sign feature data set is obtained through fusion processing, and initial dialysis parameters are generated; analyzing the sign feature data set to obtain blood vessel state parameters; adjusting a circulation system based on the blood vessel state parameters and the initial dialysis parameters to obtain circulation control data; monitoring a dialysate path by using the circulation control data, and generating a liquid path operation parameter; the circulation control data and the liquid path operation parameters are integrated to analyze the system state, and equipment early warning indexes are formed; and evaluating equipment operation according to the early warning index and generating an automatic control instruction. According to the method, deep integration of the physical sign characteristic data of the patient and the equipment operation data is realized, a data-driven objective decision basis is provided for the dialysis process, and the safety and effectiveness of dialysis treatment are improved.

A system, method, and article for delivering an antimicrobial agent into the lumen of a trans-dermal catheter are disclosed. In an embodiment, the system comprises an elongate member configured for insertion into a lumen of a catheter, and the elongate member containing an antimicrobial. An antimicrobial agent can be placed on an interior surface of a retaining ring.

The invention relates to the technical field of hemodialysis monitoring, and provides a hemodialysis on-line monitoring system and method, and the system comprises a data acquisition module which is used for collecting blood physiological parameters in a dialysis pipeline in real time; the blood component analysis module is connected with a blood loop of the dialysis machine and is used for detecting serum iron, ferritin and ferritin saturation indexes on line; and the data processing module is used for calculating the risk index of anemia, evaluating the iron utilization rate, constructing a model for measuring the iron deficiency erythropoiesis trend according to the collected and analyzed data, and training and optimizing the model. According to the method, individual parameters of patients are fused, personalized calculation is performed for iron metabolism rates and dialysis parameters of different patients, and data such as iron content, blood flow and dialysis fluid volume are acquired online in real time, so that iron concentration and infusion rate are accurately matched with real-time iron metabolism requirements of the patients, and anemia of the patients in the dialysis process is reduced.

A packaged, sealed container system for stable storage of a formulation of an oxygen-sensitive pharmaceutical compound, the packaged, sealed container system comprising a primary container including therein a formulation of an oxygen-sensitive pharmaceutical compound, a secondary outer container comprising a first flexible sheet layer, an opposing second flexible sheet layer, and a seal disposed along a common peripheral edge of the first and second flexible sheet layers, such that the primary container is disposed between and enclosed by the first and second flexible sheet layers of the secondary outer container. An oxygen scavenger is also disposed between and enclosed by the first and second flexible sheet layers of the secondary outer container. The oxygen scavenger is in fluid communication with the contents of the primary container.

Provided are photocurable resins comprising a poly(siloxane)-based copolymer together with a photoinitiator, and other optional ingredients such as a photocurable diluent, a photoabsorber, a photosensitizer, or a hydrophillic additive. Also provided are methods of stereolithographically printing a 3-D object from a disclosed resin. Also provided is an improved method for stereolithographically printing a 3-D object, the improvement comprising the use of a disclosed photocurable resin. Further provided is a 3-D microfluidic device such as an artificial lung prepared from a disclosed photocurable resin.

There is provided an introducer system for percutaneously delivering a first and a second medical device to a patient. The system may comprise an introducer sheath having a longitudinal axis and a lumen formed therein. The system may also comprise a bifurcated hub coupled to a proximal end of the sheath. The hub may comprise a first arm having a first lumen and a first hemostasis valve for the passage of the first medical device. The hub may also comprise a second arm coupled to the first arm and having a second lumen and a second hemostasis valve for the passage of the second medical device. Further, the hub may comprise a connection port such that the first lumen and the second lumen are in communication with the lumen of the introducer sheath for the passage of at least one of the first and second medical devices through the introducer sheath for delivery to the patient.

The invention discloses a modified hollow fiber membrane which is composed of a separation layer, a supporting layer and a macroporous layer, the pore diameters of the separation layer, the supporting layer and the macroporous layer are sequentially increased, and a preparation method of the modified hollow fiber membrane comprises the following steps: weighing polyether sulfone / polysulfone, a pore-foaming agent, a solvent, an organic macromolecular additive and an inorganic salt additive according to the proportion to prepare a spinning solution; stirring and dissolving at 80-180 DEG C, centrifugally filtering, defoaming at 40-80 DEG C to obtain a spinning solution, carrying out coagulating bath on the spinning solution, molding, cleaning, stretching and drying to obtain the modified hollow fiber membrane. According to the preparation method, micromolecular inorganic salt pore-forming agents with different concentrations are added into a spinning solution and a coagulating bath, and interaction among inorganic salt, a polymer and a solvent is utilized, so that an inner skin layer structure and an outer skin layer structure of the hollow fiber membrane are adjusted, and a unique three-layer structure of a separation layer, a supporting layer and a macroporous layer is formed; the hydrophilic performance is stable, and the clearance on middle molecules is improved.

The present application belongs to the field of medical device technology, and discloses a blood purification device and an operation method thereof, wherein the device comprises: a mobile trolley, a fixed bracket, a purification mechanism and an abnormal monitoring mechanism; a fixed bracket is provided on the mobile trolley, and a purification mechanism is provided on the fixed bracket; an abnormal monitoring mechanism is fixedly provided on the fixed bracket; the purification mechanism comprises an arterial pot, a dialyzer, a venous pot, a blood pump, a replacement fluid storage box, an ultrafiltrate collection box, a dialysate storage box, a replacement fluid pump, an ultrafiltrate pump, an arterial tube, a venous tube, a dialysate pump and a heparin pump, and a purification capacity evaluation module is fixedly provided on the fixed bracket. The present invention continuously monitors the blood purification process through the abnormal monitoring mechanism, promptly discovers abnormal conditions in the blood purification process, evaluates the dialysis effect of the dialyzer according to the monitoring data, and ensures that when the main dialyzer fails or has problems, the standby dialyzer can be immediately activated by setting two dialyzers, so as to ensure the continuity of the dialysis process and the safety of the patient.

To achieve a water treatment device capable of effectively using concentrated water which is a residue of electrolytic water after reverse osmotic membrane treatment.SOLUTION: A water treatment device 10 includes: an electrolytic device 30; a raw water supply passage 20A for supplying raw water 2 to a cathode chamber 36; an electrolytic water supply passage 34A connected to the cathode chamber 36 for causing electrolytic water 3 generated by the electrolytic device 30 to flow out; a reverse osmotic membrane treatment device 40 connected to the electrolytic water supply passage 34A for generating reverse osmotic electrolytic water 5 by subjecting the electrolytic water 3 supplied by the electrolytic water supply passage 34A to reverse osmotic membrane treatment; and a control unit 55 for controlling a water treatment operation in the electrolytic device 30 and the reverse osmotic membrane treatment device 40. A concentrated water discharge passage 43 for discharging concentrated water 6 which is a residue of reverse osmotic electrolytic water 5 in the reverse osmotic membrane treatment is connected to the reverse osmotic membrane treatment device 40, and the concentrated water discharge passage 43 is connected to an anode chamber 37 so as to supply the concentrated water 6 to the anode chamber 37.SELECTED DRAWING: Figure 2

The invention relates to the technical field of medical prediction, in particular to a digital twinborn prediction method for patient lung protective ventilation supported by ECMO, which comprises the following steps: extracting flow velocity change and jump points under the support of ECMO, constructing a ventilation fluctuation trend map, identifying fluctuation sections by combining compliance and pressure value ratio, delimiting lung partitions and analyzing oxygenation ratio trend. And generating an oxygenation capability classification graph, sequencing ventilation path effects, and outputting a pulmonary protective ventilation digital twinborn prediction scheme. According to the method, dynamic response mapping of ventilation behaviors is established on the basis of timing sequence changes of breathing flow velocity jump characteristics and compliance pressure value ratios, the lung regional ventilation state is accurately recognized, lung function zoning division is achieved by combining oxygenation ratio waveform classification, ventilation path utility sorting is completed through oxygenation descending characteristics under path coverage, and the lung function evaluation accuracy is improved. And a path state prediction sequence is constructed by fusing the change relationship between the tensile stress and the ventilation pressure, so that the dynamic adaptability of the ventilation strategy to the lung mechanics and oxygenation state and the region matching precision are improved.

The invention relates to the technical field of deep learning, in particular to a dialysis hypotension risk prediction system and method based on deep learning, and the system comprises a multi-point signal collection module, a signal processing module, a multi-scale causal expansion convolutional network prediction module, an osmotic pressure correction module and a dialysis plan automatic adjustment module. The method comprises the following steps: synchronously collecting physiological signals of a patient through a finger tip photoelectric volume sensor and a radial artery piezoelectric sensor array, carrying out band-pass filtering and morphological refinement processing on the signals, extracting features, and calculating pulse wave conduction time and a change rate thereof; inputting the characteristic parameters into a multi-scale causal expansion convolutional network to predict the hypotension risk in dialysis; dynamically correcting the prediction result according to electrolyte monitoring data; based on the corrected risk, a hierarchical response strategy is adopted to automatically adjust dialysis parameters, a multi-scale causal expansion convolutional network is adopted to capture physiological parameter changes on different time scales at the same time, and high-precision prediction of hypotension is achieved.

The utility model relates to the field of medical instruments, in particular to a dilution system structure for hemodialysis, which comprises a front dilution loop, a rear dilution loop, a displacement liquid outlet, a dialyzer and a controller. Displacement liquid of the displacement liquid outlet flows into the dialyzer through the front dilution loop, and dialysate flowing out of the dialyzer and the displacement liquid of the displacement liquid outlet flow into a human body through the rear dilution loop; the front dilution loop comprises a front dilution displacement pump, and the rear dilution loop comprises a rear dilution displacement pump; the problems that existing hemodialysis synchronous mixing and diluting treatment effects are poor and flexibility is poor are solved. The operation modes of the front dilution replacement pump and the rear dilution replacement pump are changed through the connection mode of the front dilution loop and the rear dilution loop, and flexible adjustment of the dialysis mode is achieved; the hemodialysis treatment effect can be effectively improved by monitoring the hemodialysis process in real time and automatically adjusting the hemodialysis parameters according to the monitoring result.

A prismatic reflector is provided for incorporation into a centrifugal separation chamber. The prismatic reflector is formed of a light-transmissive material and includes inner and outer walls and first and second end walls. The inner wall is configured to receive light traveling along an initial path and transmit the light to the first end wall, with the first end wall receiving the light transmitted through the inner wall and directing the light toward the second end wall in a direction that is angled with respect to the initial path. The second end wall receives the light from the first end wall and transmits the light out of the prismatic reflector. The initial path of the light may be in a direction toward a rotational axis of the centrifugal separation chamber, with the prismatic reflector redirecting the light into a direction substantially parallel to the rotational axis.

The invention discloses a hemodialysis puncture needle fixator, and relates to the technical field of medical instruments. The hemodialysis puncture needle fixator comprises a connecting rod, a puncture needle placing plate, a base, a sliding block and a fastening screw, the base is used for being placed in front of a puncture position of a patient, and sliding grooves perpendicular to the edges of the front side, the rear side and the right side of the upper surface of the base are formed in the front side, the rear side and the right side of the upper surface of the base; the puncture needle placing plate is arranged on the upper surface of the base, is positioned among the three chutes, and is parallel to the front side edge and the rear side edge of the upper surface of the base; the number of the connecting rods and the number of the sliding blocks are both three, connecting lugs are arranged on the upper surfaces of the sliding blocks in an upward protruding mode, and the three sliding blocks are arranged in three sliding grooves in the base in a sliding mode. The middle areas of the front side wall and the rear side wall of the puncture needle containing plate are perpendicularly and rotationally connected with rotating shafts, and connecting lugs are arranged at the ends, opposite to the ends connected to the puncture needle containing plate, of the rotating shafts. According to the hemodialysis puncture needle fixator, the fixing angle of the puncture needle can be changed at will, and high efficiency of dialysis treatment is effectively guaranteed.

The present disclosure relates to a membrane prepared from a blend comprising i) a polysulfone, polyether sulf one or polyarylethersulfone and ii) polyvinylpyrrolidone, characterized in that the membrane is coated with polydopamine and chon-droitin. Optionally the coating further comprises heparin. The disclosure further relates to a process for producing the coated membrane, a method of increasing the selectivity of a membrane, and to a filtration / diffusion device comprising the membrane which can be used, for example, in hemodialysis applications.

A polymer of formula I. and uses of the polymer for the removal of removing per- and polyfluoroalkyl substances from aqueous solutions.

The invention relates to the technical field of hemodialysis, and discloses a hemodialysis ultrafiltration amount adjusting system based on multi-parameter self-adaptive control, which is used for solving the problem of insufficient prediction and prevention precision of a hemodialysis induced hypotension risk in a traditional system. According to the method, firstly, multi-parameter physiological data of the blood volume, the blood pressure and the ion concentration are synchronously collected in the whole dialysis process, then a physiological state data set is constructed through unified standardization and correlation matching, related change modes of the blood volume and the blood pressure are extracted, and ion deviation is superposed to form comprehensive risk characteristics; the risk characteristics are compared with a preset threshold value through trend analysis, the weight of each risk component is adjusted in a self-adaptive mode, a hypotension risk trend index is generated, the ultrafiltration rate is dynamically adjusted in a graded mode according to the indexes, the indexes are coupled with a real-time physiological data feedback closed loop, and therefore the prediction precision and the regulation and control refinement level of dialysis-induced hypotension are improved.

The utility model discloses a dialysis phototherapy device and system, the dialysis phototherapy device comprises a base, a heat dissipation disc bracket, a metal heat dissipation disc, a phototherapy lamp set and an operation panel, the heat dissipation disc bracket is arranged on the top of the base; the metal radiating disc is mounted at the top of the radiating disc bracket, radiating fins are arranged at the bottom of the outer side of the metal radiating disc, a circular lamp strip groove is formed in the top of the outer side of the metal radiating disc, a circuit board is arranged at the top in the metal radiating disc, and a radiator is arranged at the lower part in the metal radiating disc; the phototherapy lamp set comprises an outer side lamp strip, an inner side lamp strip and a bottom lamp panel which are connected with the circuit board, a groove-shaped lampshade is arranged above the phototherapy lamp set, and the shape and the position of the groove-shaped lampshade are matched with those of the lamp strip grooves; and the dialysis tube is mounted in the groove of the groove-shaped lampshade through the dialysis tube mounting hole. The dialysis treatment device can enhance the dialysis treatment effect, contributes to accelerating metabolism and helping the body to discharge wastes and toxins, and is reasonable in structure, small in occupied area, convenient to operate, low in temperature and safe and reliable to use.

The invention relates to the technical field of medical instruments, in particular to an internal fistula blood vessel detection system for hemodialysis, which comprises a data acquisition module for acquiring ultrasonic data, an impedance value, tremor intensity and a pressure spectrum; the mode determining module is used for determining a detection mode of the internal fistula blood vessel based on the tortuosity index and determining massage frequency and air bag pressure according to the blood vessel compliance index; the stenosis analysis module is used for determining whether the internal fistula blood vessel is stenosis or not based on the stenosis risk characterization parameter and determining whether the stenosis degree of the internal fistula blood vessel is in a reasonable range or not according to the blood flow velocity characterization value; the frequency adjusting module determines and adjusts the massage frequency based on the ratio; the injury analysis module is used for determining whether the internal fistula blood vessel is injured or not in the dialysis process on the basis of the bioelectrical impedance change rate and determining whether the internal fistula blood vessel injury is in a reasonable range or not after dialysis according to the tremor intensity change value; the pressure adjusting module determines and adjusts the pressure of the air bag based on the difference value. The accuracy of internal fistula blood vessel detection is improved.

The invention belongs to the field of membrane materials, and particularly relates to a permeable membrane with a COF layer growing on the surface and a preparation method and application of the permeable membrane. According to the invention, aldehyde monomers are introduced into a membrane casting solution for blending, and a porous basement membrane with aldehyde groups on the surface is obtained through a phase inversion method; then, the aldehyde group porous substrate membrane is put into an acid reaction solution containing aldehyde monomers and sufficient amine monomers containing guanidine groups in an in-situ growth mode to obtain the porous permeable membrane with the multi-amino COF growing on the surface, the porous substrate guarantees good gas permeability, and the thin and compact surface also guarantees that the membrane does not leak liquid for a long time. In addition, enrichment of amino groups on the surface also promotes affinity of the material to carbon dioxide, and gas exchange in ECMO application is facilitated. In addition, the COF layer grown on the surface also improves the protein adhesion resistance of the porous basement membrane.

The invention discloses a dialysate regeneration system and dialysis equipment, the dialysate regeneration system comprises a waste liquid passage, a slow flow box, an electromagnetic valve, a reactor and an adsorption mechanism, the waste liquid passage is in through connection with the slow flow box, the slow flow box is connected with the reactor through a pipeline, and the pipeline is provided with the electromagnetic valve. The fixing amount of a urease layer is increased through the treatment film with the three cambered surfaces, the urea decomposition efficiency is improved, the diffusion path of toxins on the treatment film is shortened, meanwhile, the treatment film with the cambered surface structure can guide dialysis waste liquid entering the reactor to generate local turbulence, and the toxins are prevented from being accumulated on the surface of the treatment film; the dialyzer is arranged, the micro horse is started to drive the hollow fiber to rotate, the material exchange efficiency of blood and dialysate is improved, and the situation that protein and cells are deposited on the surface of the hollow fiber, and the service life of the hollow fiber is shortened is avoided.

The utility model discloses a heat dissipation system and a metal heat dissipation disc used for an auxiliary dialysis phototherapy device, the auxiliary dialysis phototherapy device comprises a base, a phototherapy lamp set and an operation panel, the heat dissipation system comprises the metal heat dissipation disc and a heat dissipation device, the metal heat dissipation disc comprises a heat dissipation disc main body and a heat dissipation disc outer ring, and the heat dissipation disc main body and the heat dissipation disc outer ring are arranged on the base. The heat dissipation disc body is arranged in the heat dissipation disc outer ring and integrally formed with the heat dissipation disc outer ring, a round lamp strip groove is formed in the front face of the heat dissipation disc body, a middle fin structure is arranged at the position, at the lamp strip groove, of the back face of the heat dissipation disc body, and the heat dissipation disc body is arranged above the base through the heat dissipation disc bracket. The operation panel is installed above the heat dissipation disc body, the heat dissipation disc outer ring protrudes out of the edges of the heat dissipation disc bracket and the operation panel, and an outer edge fin structure is arranged on the back face of the heat dissipation disc outer ring. The auxiliary dialysis phototherapy device can be greatly cooled, the temperature of blood in the dialysis tube is prevented from rising, and the dialysis treatment effect is enhanced.

The invention relates to the technical field of medical monitoring, and discloses an intelligent monitoring device for a blood return end of hemodialysis, the device is in communication connection with a dialyzer for hemodialysis, and the device comprises an alarm trigger module, a temperature compensation module and a screen display module. According to the application, the alarm triggering module accurately monitors the blood return temperature, the blood return flow velocity and the induced blood flow velocity, captures abnormity in real time and triggers alarm; the temperature compensation module not only guarantees life safety of the patient, but also improves temperature control adaptability; the screen display module displays core parameters and trend curves in real time, space limitation is broken through, and medical workers are assisted in remote quick response; the portability of the device is realized by the micro clamping and fixing module; the clinical flexibility is enhanced through threshold adjustment; the power-on self-test further ensures the operation safety of the equipment; therefore, full-process optimization from data monitoring, intelligent control to remote monitoring is realized, and accurate, safe and personalized dialysis support is provided for patients.

The invention discloses a dual-modified polyethersulfone membrane and a preparation method thereof, and relates to the technical field of polyethersulfone membranes. According to the technical scheme, the preparation method comprises the following steps: carboxylating polyether sulfone to obtain carboxylated polyether sulfone; the preparation method comprises the following steps: carrying out cationization treatment on chitosan to prepare cationic chitosan; the prepared carboxylated polyether sulfone, cationic chitosan and an additive are prepared into the dual-modified polyether sulfone membrane through a phase inversion method. The problems of general membrane forming property, insufficient infiltration capacity, poor hydrophilicity, membrane body pollution and the like of the polyether sulfone membrane in the actual use process are solved, meanwhile, the biocompatibility of the polyether sulfone membrane is improved, and the service life of the membrane is also greatly prolonged.

The invention discloses an extracorporeal circulation system and a control method thereof, and relates to the technical field of medical instruments. The extracorporeal circulation system comprises a membrane oxygenator, a microembolus filter, a rolling pump, a first pressure detector and a second pressure detector; a liquid inlet of the membrane oxygenator is communicated with the arterial cannula; the microembolus filter is circularly communicated with the membrane oxygenator, and the liquid outlet end of the microembolus filter is communicated with the venous cannula; the rolling pump is circularly communicated with the membrane oxygenator; the first pressure detector is communicated with the rolling pump and is used for detecting the outlet liquid pressure of the rolling pump and generating a first pressure signal; the second pressure detector is communicated with the microplug filter and is used for detecting the inlet liquid pressure of the microplug filter and generating a second pressure signal; the structure of the extracorporeal circulation system and the control method of the extracorporeal circulation system are improved, the accuracy and timeliness of medical staff for judging the oxygenation effect of the membrane type oxygenator are improved, the membrane type oxygenator can be replaced in time, a large number of complications can be avoided, and the death rate of patients is reduced.

The invention discloses an in-vitro pipeline and filter blood coagulation monitoring method and system, and belongs to the technical field of intelligent medical instruments, and the in-vitro pipeline and filter blood coagulation monitoring method comprises the following steps: S1, obtaining operation data and operation parameters of a corresponding hemodialysis machine and biochemical indexes of a patient corresponding to the hemodialysis machine based on a pipeline and a filter; optimizing the long-short-term memory network based on a doliolaria group optimization algorithm to obtain a monitoring model; s2, preprocessing the operation data, the operation parameters and the biochemical indexes to obtain a training set, a verification set and a real-time data set; s3, training the monitoring model based on the training set and the verification set to obtain a real-time monitoring model; s4, inputting the real-time data set into a real-time monitoring model to obtain blood coagulation grades of the pipeline and the filter; s5, the corresponding in-vitro pipeline and filter blood coagulation monitoring system executes an early warning action based on the early warning rule and the blood coagulation level; the blood coagulation level of the pipeline and the filter is monitored through the interrelation of the operation data and the operation parameters of the hemodialysis machine and the biochemical indexes of the patient, and the recognition accuracy of the blood coagulation event is remarkably improved.

The disclosure relates to a method including determining a treatment time of a dialysis treatment for a patient, receiving, from at least a sensor of a dialysis machine, a dialysate flow rate, the dialysate comprising bicarbonate pumped out of a bicarbonate source, wherein the bicarbonate source has an initial amount of bicarbonate, and predicting that by end of the dialysis treatment no more than a threshold amount of bicarbonate will be left in the bicarbonate source, and in response, determining that a clearance value during the treatment is or will be higher than the threshold clearance value, and sending, to a balancing system, an instruction to reduce the dialysate flow rate to a reduced rate, wherein the reduced rate results in reducing a rate of bicarbonate pumped out of the bicarbonate source while maintaining a clearance value of the treatment at no less than the threshold clearance value.