The invention discloses a collagen extraction and purification system. The collagen extraction and purification system comprises the following devices of a degreasing tank, a leaching device, a crusher, an enzymolysis tank, a refrigerated centrifuge, an alkali-washed tank, a salting-out unit, a filter unit, a dialysis unit and a freeze drying unit which communicate with each other in sequence, wherein the degreasing tank and the leaching device degrease raw materials, the crusher crushes the degreased raw materials, the enzymolysis tank conducts enzymolysis treatment on the crushed raw materials, the refrigerated centrifuge conducts refrigerated centrifugation treatment on enzymatic hydrolysate, the alkali-washed tank conducts alkali washing treatment on precipitates obtained by refrigerated centrifugation, the salting-out unit conducts salting-out treatment on alkali wash water, the filter unit and the dialysis unit purify coarse collagen subjected to salting-out, and the freeze drying unit cures a purified collagen solution. The collagen extraction and purification system is high in extraction efficiency, and the purity of obtained products is high.