787results about "Cation exchanger materials" patented technology

The present disclosure relates to the extraction of lithium from liquid resources such as natural and synthetic brines, leachate solutions from clays and minerals, and recycled products. Herein are systems and processes for extracting lithium using ion exchange materials, where transition metal impurities may be removed from the synthetic lithium solution. In some embodiments, the transition metal species are reformulated to form ion exchange materials to be used in the systems and processes described herein.

A method is provided, comprising: obtaining, for a chromatography machine including a first dispersed plug flow reactor (DPFR) and a continuous stirred tank reactor (CSTR) prior to a column, and a second DPFR after the column, geometric measurements associated with the second DPFR; generating, by a processor, transport model parameters for a transport model associated with the second DPFR based on the geometric measurements; feeding a tracer molecule into the chromatography machine; capturing one or more tracer molecule measurements based on the tracer molecule traveling through the chromatography machine; and estimating, by the processor, based on the transport model associated with the second DPFR and the one or more tracer molecule measurements based on the tracer molecule traveling through the chromatography machine, one or more transport model parameters for a transport model associated with the first DPFR and the CSTR.

Provided is a cation exchange membrane in which when a hydroxide aqueous solution showing strong alkalinity is produced by using an electrodialyzer, significant swelling in the cation exchange membrane in contact with the hydroxide aqueous solution is suppressed, destruction of a cation exchange resin due to polyvalent cations contained as impurities in a raw material inorganic salt is suppressed, and the capacity of the cation exchange membrane is hardly lowered.　This cation exchange membrane is characterized by having an electric resistance of 2.0-5.0 (Ω∙cm2), as measured at 25ºC in 0.5 mol / L of a NaCl aqueous solution, and a dimensional change rate of at most 1.2%.

A bipolar membrane in which a cation-exchange membrane and an anion-exchange membrane are joined to each other, wherein a leakage ratio of gluconic acid at 60° C. is not more than 1.0%, and the cation-exchange membrane is supported by a polyolefin reinforcing member and, further, contains a polyvinyl chloride.

The invention discloses a method for extracting a target product from a milk raw material, and relates to the technical field of food processing. According to the method, before strong anion exchange chromatography is carried out, a synergistic pretreatment step of ultrafiltration and conductivity adjustment is introduced, so that acceleration, synergism, quality improvement and cost reduction of the chromatography process are realized, and the technical bottlenecks of low speed, easiness in pollution, instability and the like of the traditional ion exchange chromatography during treatment of milk raw materials are overcome; and a solution is provided for high-efficiency, high-purity and large-scale production of the beta-lactoglobulin and the alpha-lactalbumin. According to the method, strong anion exchange chromatography and weak anion exchange chromatography can be combined, so that the extraction purity of beta-lactoglobulin and alpha-lactalbumin can be further improved; in addition, the method can synchronously realize high-efficiency extraction of various target substances such as casein micelles, lactose and milk mineral salts, so that the additional value and resource utilization efficiency of milk source byproducts are greatly improved.

The present invention provides a kit and a detection method for synchronously detecting catecholamines and their metabolites, which relates to the technical field of analytical detection. The kit contains a diluent, a solid-phase extraction reagent, an LC-MS / MS detection reagent, a solid-phase extraction device, and a solid-phase extraction packing material. Among them, the solid-phase extraction packing material creatively adopts zwitterionic exchange microspheres containing both carboxyl and quaternary ammonium groups. The kit can not only synchronously and efficiently separate and detect 8 kinds of catecholamines and their metabolites in urine samples, but also separate and detect 6 kinds of amino-containing catecholamines and their metabolites in blood samples. When the above kit is used to separate and detect catecholamines and their metabolites, the extraction recovery rate is relatively high, and the linear range covers the reference value range of normal detection, which can significantly shorten the detection time of urine samples, improve the detection efficiency of mass spectrometry, and is conducive to popularization and application in clinical detection.

A full solid-waste micro-expansive concrete and its preparation method are provided, and relate to the field of concrete material technologies. The full solid-waste micro-expansive concrete includes the following components in parts by weight: 920-1060 parts of a coarse aggregate, 460-582 parts of a fine aggregate, 11-19 parts of an expansive agent, 389-512 parts of a modified solid-waste-based cementitious material, and 231-268 parts of water. The coarse aggregate is coal gangue. The fine aggregate is waste ceramic. The modified solid-waste-based cementitious material includes a solid-waste-based clinker, modified polyvinyl alcohol, and a modified anion exchange resin. The solid-waste-based clinker is prepared from the coal gangue, carbide slag, and desulfurization gypsum. The expansive agent is obtained by calcining the carbide slag. The concrete prepared can ensure the initial strength of the concrete, and guarantee continuous micro-expansion in the later stage, compensating for shrinkage and thereby increasing the overall strength of the concrete.

Systems and methods for generating radionuclides, such as radium-224. Systems herein may include a first cartridge having a first opening, a second opening, and a chamber therebetween having a first resin having affinity for thorium-228 and bismuth-212; a second cartridge having a first opening, a second opening, and a chamber therebetween having a second resin having affinity for thorium-228 and bismuth-212, a third cartridge having a first opening, a second opening, and a chamber therebetween comprising a third resin having affinity for thorium-228 and bismuth-212, a fourth cartridge having a first opening, a second opening, and a chamber therebetween having a third resin having affinity for lead-212; wherein a continuous flow path is formed from a top of the first cartridge though the second cartridge, through the third cartridge, and to a bottom of the fourth cartridge during system use.

The invention discloses a method for preparing radiation-resistant polystyrene resin and controlling the aperture of the radiation-resistant polystyrene resin. The preparation method of the radiation-resistant polystyrene resin comprises the following steps: fully dissolving polyvinyl alcohol in deionized water, adding an organic phase containing styrene and the like into the deionized water, uniformly stirring and mixing, heating and carrying out a synthetic reaction to prepare non-porous matrix microspheres, and carrying out pore-forming and surface modification treatment on the matrix microspheres. Compared with the prior art, rapid preparation of the radiation-resistant porous mass transfer resin is achieved through two steps, the high grafting rate is kept through accurate control over a cross-linked skeleton, meanwhile, radiation resistance is considered, and the method has the advantages that the process is simple, the cost is low, the particle size is controllable and narrow in distribution, relevant parameters are easy to standardize, and the method is suitable for industrial amplification.

The invention relates to the technical field of biomacromolecule separation and purification engineering, and discloses a chromatographic separation method for removing endotoxin in a vaccine preparation, which comprises the following steps: preparing an equilibrium buffer solution containing citrate with specific concentration and L-arginine hydrochloride; providing a mixed mode chromatography medium with hydrophobic and ion exchange complex ligands and balancing with a buffer; according to the method, through the synergistic effect of 8.0-12.0 mmol / L of citrate and 150-250 mmol / L of L-arginine hydrochloride, the endotoxin micelle structure is destroyed and is induced to be dissociated into monomers, and meanwhile, L-arginine is used for inhibiting monomer aggregation, so that the monomers are diffused into inner holes of the medium in a small size to be adsorbed, and the endotoxin micelle structure is separated into the medium. Therefore, the problem of separation caused by size overlapping of endotoxin micelles and antigens is solved, and double breakthrough of deep removal of endotoxin and high recovery rate of antigens is realized.

A problem to be solved by the present invention is to provide an ion exchange membrane that can increase the surface area of a membrane effective for ion permeation, properly decreases the electric resistance of a flow passage between membranes and the attachment of a contaminating substance thereto, also enhances the mechanical strength of the membrane itself, and further, is less deformed or damaged due to swelling over a wide range of salt concentrations and even if there is a large difference in salt concentration between two solutions contacted with the membrane. The present invention provides an ion exchange membrane having a concavo-convex shape, wherein the ion exchange membrane has a flat portion in the vicinity of ends, and a convex curve and a concave curve resulting from curvatures of the ion exchange membrane itself form a convex part and a concave parts, respectively, in the concavo-convex shape of the ion exchange membrane, wherein the convex part extends linearly or curvedly, the concave part between the convex parts is flat, the concave part includes a first concave part adjacent to the convex part in the lateral direction of the convex part, along the longitudinal direction of the convex part, the convex part has an apex and a side face in the longitudinal direction, and the side face is inclined from the apex toward the first concave part.

The invention provides a production process of SEMI-G5-grade high-purity NMP (N-Methyl Pyrrolidone), which is characterized in that metal ions, magnetic foreign / non-magnetic foreign particulate matters and the like of conventional industrial-grade NMP are completely removed by adopting a multi-section rectification, resin adsorption and precise filtration process, so that the SEMI-G5-grade NMP reaches the SEMI-G5 grade in an ultra-clean high-purity reagent; and the use requirements on the ultra-clean high-purity NMP in the fields of semiconductors, integrated circuits and novel display are met.

The invention discloses a strongly acidic cation exchange chromatography material and a preparation method thereof. The chromatography material takes microspheres as a matrix material, and takes halogenated alkyl sodium benzenesulfonate and hydroxyl-containing halogenated alkyl sodium sulfonate as functional groups. The preparation method comprises the following steps: epoxy activation: dispersing microspheres in a continuous phase, adding a reducing agent, an alkaline solution and a grafting reagent, and reacting to obtain epoxy activated microspheres; preliminary sulfonation: enabling the epoxy activated microspheres to react with hydroxyl-containing halogenated alkyl sodium sulfonate serving as a first sulfonating agent under an alkaline condition to obtain preliminarily sulfonated microspheres; deep sulfonation: enabling the preliminarily sulfonated microspheres to react with halogenated sodium alkyl benzene sulfonate serving as a second sulfonating agent to obtain a target product. The strongly acidic cation exchange chromatography material provided by the invention can achieve the effects of high protein adsorption capacity and high ion exchange site density.

The invention relates to benzenesulfonic functionalized silica gel as well as a preparation method and application thereof, and the preparation method comprises the step of reacting silica gel with 2-(4-chlorosulfonylphenyl) ethyl trichlorosilane in a solvent to obtain the benzenesulfonic functionalized silica gel. The benzenesulfonic acid group functionalized silica gel provided by the invention has high surface coverage rate and sulfonic acid group modification degree, shows excellent separation selectivity for at least 15 rare earth elements, and can be used in macro preparation of high-purity rare earth.

Methods, devices, and systems are disclosed that capture carbon dioxide from ambient air and / or point source emissions and produce carbon dioxide from the captured atmospheric and / or point source carbon dioxide using one or more products of the carbon capture processes. Implementations filter atmospheric and / or point source impurities during the carbon capture process and in steps for producing a CO2 stream via chemical synthesis and optionally thermal generation. The integration of CO2 removal processes and chemical synthesis of CO2 synergistically combine to reduce and / or eliminate waste streams, resulting in efficient processes with low carbon emissions and reduced waste.

A waste extraction system that includes a column set positioned between and fluidly coupled to an upstream segment of a main waste pathway and a column effluent tank, the column set having a uranium adsorption column fluidly coupled to a supporting adsorption column along the main waste pathway. The uranium adsorption column is upstream the supporting adsorption column. The waste extraction system also includes a strip waste pathway extending from the uranium adsorption column to the column effluent tank bypassing the supporting adsorption column, an anion exchange resin housed in the uranium adsorption column, and a cation exchange resin housed in the supporting adsorption column.

To provide methods of reducing bioburden of a chromatography resin.SOLUTION: Provided herein are methods that include exposing a container including a composition including (i) a chromatography resin and (ii) a liquid including at least one alcohol to a dose of gamma-irradiation sufficient to reduce the bioburden of the container and the chromatography resin, where the at least one alcohol is present in an amount sufficient to ameliorate the loss of binding capacity of the chromatography resin after / upon exposure to the dose of gamma-irradiation. Also provided are: reduced bioburden chromatography columns including the reduced bioburden chromatography resin; compositions including a chromatography resin and a liquid including at least one alcohol; and methods of performing reduced bioburden column chromatography using one of these reduced bioburden chromatography columns.SELECTED DRAWING: Figure 1

A method is provided of continuous manufacturing of Actinium-225 from a radium generator by repeating chemical purification is provided.

The invention relates to the technical field of hydrometallurgy, in particular to a method for preparing an adsorption unit for lithium recovery and use of the adsorption unit. On the basis of a patent CN102631897B, the invention innovatively proposes preparation of an adsorption unit by performing extrusion forming on pulverized lithium adsorbent resin or a lithium adsorbent precursor and an adhesive, the adsorption unit has both high selectivity and adsorption amount of the lithium adsorbent resin and can achieve high-efficiency adsorption of lithium in water with an ultra-low lithium content, and when the adsorption unit is used for adsorbing lithium in the water with the ultra-low lithium content, the entire adsorption process is simple, the desorption efficiency is high and the cost is low.

The invention belongs to the technical field of membrane separation, and particularly relates to a preparation method of a self-supporting polypyrrole composite membrane and application of the self-supporting polypyrrole composite membrane in extraction of lithium from a salt lake. A polyoxazole polyhydrazide copolymer is used as a porous self-supporting base membrane, and a continuous polypyrrole functional layer is constructed on the surface of the base membrane through in-situ oxidative polymerization. A dynamic charge screening microenvironment is formed by a weak positive electricity characteristic and a highly conjugated structure in a polypyrrole molecular chain, and the interception efficiency on high-charge-density magnesium ions is enhanced through electrostatic interaction; and meanwhile, the rigid pore structure realizes selective permeation of lithium ions through size screening. Under the assistance of an external electric field, the polypyrrole layer shows excellent magnesium-lithium separation performance, lithium ions are enriched and recycled from the salt lake brine with the high Mg < 2 + > / Li < + > molar ratio, and the industrial bottleneck that ion flux and selectivity are difficult to consider at the same time in a traditional separation technology is solved.

The invention provides a tungsten adsorption-desorption system, comprising: a feeding pipeline, which is respectively communicated with a sulfuric acid feeding pipe, a pure water feeding pipe, a sodium hydroxide feeding pipe and a lepidolite leachate feeding pipe; the bottom of the first HP1053 resin column is communicated with the feeding pipe through a first pipeline, a first electromagnetic valve is arranged on the first pipeline, and the bottom of the first HP1053 resin column further comprises a first waste discharge pipeline; the bottom of the first HP1053 resin column is communicated with the feeding pipe through a first pipeline, the bottom of the second HP1053 resin column is communicated with the feeding pipe through a second pipeline, a second electromagnetic valve is arranged on the second pipeline, the bottom of the second HP1053 resin column further comprises a second waste discharging pipeline, and the top of the first HP1053 resin column is communicated with the top of the second HP1053 resin column through a third pipeline. A third electromagnetic valve and a fourth electromagnetic valve are arranged on the third pipeline; and the discharging pipeline is communicated with the third pipeline between the third electromagnetic valve and the fourth electromagnetic valve, and a fifth electromagnetic valve is arranged on the discharging pipeline.

The present invention provides, inter alia, a method for regenerating an ion exchange resin which is at least partially loaded with fluoride ions in an ion exchange vessel, wherein said ion exchange resin is a metal ion-doped chelating resin comprising amino-phosphonate groups.

The utility model relates to the technical field of ergothioneine production, in particular to a production system for extracting ergothioneine from pichia pastoris fermentation liquor, which comprises a first buffer kettle, a flocculant storage tank, a first filtering device, a first clear liquid storage tank, a second buffer kettle, a second filtering device and a second clear liquid storage tank which are communicated with a fermentation liquor conveying pipeline, a discharge port of the first clear liquid storage tank and a discharge port of the second clear liquid storage tank are communicated with a mixing tank, a discharge port of the mixing tank is communicated with a third filtering device, a third buffer kettle, a cationic resin column, first concentration equipment and second concentration equipment, a concentrated solution outlet of the second concentration equipment is communicated with a crystallization kettle, and a crystal outlet of the crystallization kettle is communicated with a washing tank. A discharge hole of the washing tank is communicated with the drying device; and a discharge hole of the drying device is communicated with the product storage tank. The production system is reasonable in design, effective extraction of the ergothioneine in the pichia pastoris fermentation liquor is achieved, and the yield and purity of the ergothioneine product are greatly improved.

The present invention relates to a method for isolating Glu-Plasminogen from a solution containing Glu-Plasminogen and one or more other polypeptides, wherein the method comprises the step of eluting the Glu-Plasminogen from the cation exchange solid phase with an elution buffer of a pH in the range of 6.2 to 6.5. Furthermore, the present invention relates to a composition comprising Glu-Plasminogen obtainable from the method of the invention.

The present invention relates to methods and devices for isolating one or more biomolecules of interest from a biological composition. Specifically, the invention relates to the separation of one or more target biomolecules from a biological composition by dynamic packed bed adsorption using a separation medium comprising porous rod-like particles attached to the target molecules and filtration using a filter having a pore size of at least 1.5 [mu] m.

A substantially animal-protein free (APF) composition comprises a botulinum toxin serotype A neurotoxin having a molecular weight of 150 kDa, comprising one nanogram or less of residual nucleic acid for each milligram of the botulinum neurotoxin component, wherein the botulinum toxin serotype A neurotoxin is obtainable by a process comprising the steps of (a) providing a substantially APF fermentation medium; (b) fermenting Clostridium botulinum bacteria in the fermentation medium, and; (c) recovering the biologically active botulinum neurotoxin from the fermentation medium by contacting the fermentation medium with an anion exchange chromatography media followed by contacting an eluent from the anion exchange chromatography medium with a cation exchange chromatography media.

Disclosed herein are a polymeric material comprising a plurality of polymeric nanosheets arranged in a layer-by-layer configuration to provide a two-dimensional microporous polymeric material, wherein each of the plurality of polymeric nanosheets is formed from a plurality of ladder-shaped polymers, the ladder-shaped polymers are formed from at least one multivalent monomeric material that has: two or more polymerisable functional groups selected from one or both of acetylene and vinyl functional groups; and a functional group capable of forming a halogen bond with a halogen atom, use of the polymeric material, and a method of manufacturing the polymeric material. Also disclosed herein is a method of adsorbing Li+ and / or B3+ ions from an aqueous solution comprising a mixture of ionic species.

The present application provides a chromatographic baseline suppression device and a manufacturing method thereof, the chromatographic baseline suppression device comprises a container and two ion exchange membranes, the two ion exchange membranes divide the inside of the container into a first part, a second part and a third part, the second part has an inlet and an outlet; the chromatographic baseline suppression device further comprises two electrodes respectively in the first part and the second part, the electrodes comprise a matrix porous material layer and a polymer layer, the matrix porous material layer is conductive and is connected with the ion exchange membrane. The present application has the advantages of small noise and the like.

A macroporous cation exchange resin and its preparation and application method are disclosed. The method involves dispersing polystyrene-divinylbenzene microspheres in dichloroethane to obtain a microsphere suspension. A sulfonating agent, a mixture of fuming sulfuric acid and chlorosulfonic acid, is then slowly added dropwise under cooling and stirring conditions. After the addition is complete, heating is initiated to trigger a polysulfonation reaction. Once the reaction is complete, the reaction mixture is slowly poured into ice water and continuously stirred and diluted until the solution pH reaches 2.5. The solution is then filtered, washed, and dried to obtain a solid resin. This invention simultaneously introduces a matched number of sulfonic acid groups and sulfone groups onto the polystyrene-divinylbenzene backbone. Utilizing the electron-withdrawing effect of the sulfone groups and the rigid framework they form, the stability of the C-H and C-S bonds in the resin is enhanced. This solves the problems of resin structure damage, rapid decline in separation performance, and significantly shortened service life associated with existing cation exchange resins used in treating chromium plating aging solutions.