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1894results about "Cation exchanger materials" patented technology
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Acid Zirconium Phosphate and Alkaline Hydrous Zirconium Oxide Materials For Sorbent Dialysis
ActiveUS20100078387A1Avoid disadvantagesRestore balanceCation exchanger materialsOrganic anion exchangersIon exchangeDialysis fluid
Owner:FRESENIUS MEDICAL CARE HLDG INC
Positively charged membrane
InactiveUS6780327B1High rateHigh charge densityCation exchanger materialsIon-exchanger regenerationPorous substrateFiltration
The present invention provides a positively charged microporous membrane having a protein binding capacity about 25 mg / ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.
Owner:PALL CORP
Method of removing organic iodides from organic media
InactiveUS6225498B1Efficient removalCation exchanger materialsOrganic compound preparationAcetic acidAcetic anhydride
Owner:CELANESE INT CORP
Adsorption/separation method and a medium for adsorption/separation
InactiveUS6428707B1Increase productionImprove productivityChromatographic cation exchangersCation exchanger materialsChemistrySeparation method
A method for adsorption of a substance from a liquid sample on a fluidized bead or stirred suspension, in which the beads used comprise a base matrix and exhibit a structure having affinity to the substance, characterized in that the structure is covalently bound to the base matrix via an extender. Populations of beads in which the beads contain a filler incorporated in a base matrix and an extender are also described.
Owner:GE HEALTHCARE BIOPROCESS R&D
Exhaust system for a vehicular positive ignition internal combustion engine
ActiveUS20110158871A1Reduce frequencyImprove filtering effectCombination devicesCation exchanger materialsParticulatesPorous substrate
Owner:JOHNSON MATTHEY PLC
Process for chromatographic separation of peptides and nucleic acid, and new high affinity ion exchange matrix
InactiveUS6090288ACation exchanger materialsComponent separationChromatographic separationTransferrin
PCT No. PCT / SE97 / 00237 Sec. 371 Date Dec. 29, 1998 Sec. 102(e) Date Dec. 29, 1998 PCT Filed Feb. 14, 1997 PCT Pub. No. WO97 / 29825 PCT Pub. Date Aug. 21, 1997Process for separating off a peptide or a nucleic acid by an anion exchanger (I) characterized in that a) the anion exchanger (I) exhibits ligands, which (i) contain a primary, secondary or tertiary amino group and (ii) are covalently bound to an organic polymer (matrix), b) there on a carbon atom at a distance of 2 or 3 atoms away from an amino nitrogen in the ligands is a hydroxyl group or a primary, secondary or tertiary amino group, and c) the maximum elution ionic strength in the pH range 2-14 for at least one of the proteins transferrin, ovalbumin 1, ovalbumin 2, beta -lactoglobulin 1 and beta -lactoglobulin 2 on the anion exchanger is higher than the elution ionic strength required for a quaternary comparative ion exchanger.
Owner:GE HEALTHCARE BIOPROCESS R&D
Sorbent cartridge to measure solute concentrations
ActiveUS20140190876A1Detection problemCation exchanger materialsOrganic anion exchangersEnvironmental chemistrySorbent
A sorbent based monitoring system for measuring the solute concentration of at least one component of a fluid. The system has a sorbent regeneration system for regeneration of the fluid and has a sorbent cartridge that has at least one material layer. The fluid is conveyed through the sorbent cartridge and contacts at least one sensor after having contacted at least one material layer.
Owner:MOZARC MEDICAL US LLC
Method to adsorb an adsorbate using modified carbonaceous material
InactiveUS6863713B1Few structuresCation exchanger materialsOther chemical processesSorbentOrganic group
An adsorbent composition containing a modified carbonaceous material capable of adsorbing an adsorbate is disclosed, wherein at least one organic group is attached to the carbonaceous material. Furthermore, methods to increase the adsorption capacity of a carbonaceous material capable of adsorbing an adsorbate and methods to adsorb an adsorbate using the above-described adsorbent composition are also disclosed.
Owner:CABOT CORP
Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same
ActiveUS20090050566A1Improve bindingGood removal effectCation exchanger materialsIon-exchanger regenerationPurification methodsSorbent
Media and devices, such as anion exchangers including such media, wherein the media is a membrane having a surface coated with a polymer such as a polyallylamine. The resulting membrane offers stronger binding of protein impurities and superior removal of host cell proteins from biological samples than conventional ligands based on quaternary ammonium salts, including trimethylammonium ligands. Also described is a chromatography scheme and method for purifying monoclonal antibodies, wherein the anion exchange sorber is placed downstream of an affinity column (such as Protein A or Protein G affinity column) and optionally one or more polishing devices such as cationic exchange columns. Little or no dilution of the cation exchanger pool (or affinity column exchange pool where no cation exchanger is used) is necessary to lower the conductivity of the sample. The sorber functions well to strongly bind host cell proteins and other impurities in biological samples even at high conductivities and pH.
Owner:MILLIPORE CORP
Acid zirconium phosphate and alkaline hydrous zirconium oxide materials for sorbent dialysis
ActiveUS8409444B2Avoid disadvantagesRestore balanceCation exchanger materialsSolvent extractionIon exchangeDialysis fluid
Owner:FRESENIUS MEDICAL CARE HLDG INC
Recirculating dialysate fluid circuit for blood measurement
ActiveUS20140190886A1Short balance timeIncreasing dialysateCation exchanger materialsSolvent extractionMonitoring systemBiomedical engineering
A blood based solute monitoring system for measuring at least one blood solute species that has a first recirculation flow path in fluid communication with a dialyzer. The first recirculation flow path is configured to allow a fluid to recirculate through a dialyzer such that the concentration of at least one solute species in the fluid becomes equilibrated to the solute species concentration of the blood in a blood compartment of the dialyzer. The blood solute monitoring system has at least one sensor to measure a fluid characteristic.
Owner:MOZARC MEDICAL US LLC
Process and equipment for plasmid purification
InactiveUS8236495B2Easy to operateConsistent levelCation exchanger materialsOrganic anion exchangersEscherichia coliLysis
A scalable alkaline lysis process, including procedures and devices for the isolation of large quantities (grams and kilograms) of plasmid DNA from recombinant E. coli cells. Effective, controllable, and economical operation, and consistent low level of host chromosomal DNA in the final plasmid product. Involves a series of new unit operations and devices for cell resuspension, cell lysis, and neutralization.
Owner:URIGEN PHARMA INC
Method for preparation of anion exchange resins
InactiveUS6756462B2Reduce environmental impactReduced material requirementsCation exchanger materialsIon-exchanger regenerationPhysical chemistryIon-exchange resin
An improved process for preparing anion exchange resins based on the use of a non-agitated plug-flow quench procedure followed by recycle of a portion of the recovered chloromethylation reaction fluids into subsequent chloromethylation reactions is disclosed. The combination of plug-flow hydration, providing highly concentrated recovered sulfuric acid, together with the recycle or reuse of the recovered concentrated sulfuric acid, allows for reduced raw material requirements during anion exchange resin manufacture and reduces the environmental impact of waste sulfuric acid processing.
Owner:ROHM & HAAS CO
Zirconium phosphate recharging method and appartus
Methods and related apparatuses for sorbent recharging are provided. The methods and related apparatuses for recharging can recharge a specific rechargeable layer or module of a sorbent material such as zirconium phosphate in a sorbent cartridge. The methods and apparatuses include a fluid source containing at least one recharging fluid, wherein the fluid source is fluidly connectable to at least one rechargeable sorbent module for use in sorbent dialysis in a fluid flow path. The methods and apparatuses include passing a single solution through the zirconium phosphate for ion exchanges, resulting in zirconium phosphate to maintain a substantially consistent pH in a dialysate used during dialysis.
Owner:MOZARC MEDICAL US LLC
Positively charged membrane
The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg / ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.
Owner:PALL CORP
Porous electroactive hydrogels and uses thereof
ActiveUS20120029416A1Maximize electroactuationReduce the cross-sectional areaBiocideFinger bandagesMaterials sciencePolymer science
Owner:PRESIDENT & FELLOWS OF HARVARD COLLEGE
Process and equipment for plasmid purfication
InactiveUS20060106208A1Easy to operateConsistent levelCation exchanger materialsIon-exchanger regenerationLysisGram
A scalable alkaline lysis process, including procedures and devices for the isolation of large quantities (grams and kilograms) of plasmid DNA from recombinant E. coli cells. Effective, controllable, and economical operation, and consistent low level of host chromosomal DNA in the final plasmid product. Involves a series of new unit operations and devices for cell resuspension, cell lysis, and neutralization.
Owner:URIGEN PHARMA INC
Proton conductive membrane having improved thermal stability
ActiveUS7001929B2Improve heat resistanceElectrolyte holding meansNon-metal conductorsBoiling pointHeat resistance
The invention provides a proton conductive membrane excellent in heat resistance, which has sulfonic acid as ion exchange groups. The proton conductive membrane comprises a nitrogen-containing compound that can be mixed with water in arbitrary proportions and has a boiling point of not lower than 100. degree. C. and a proton conductive resin which has sulfonic acid ion-exchange groups, wherein the nitrogen-containing compound is contained in an amount of 0.5 to 10 parts by weight based on 100 parts by weight of the proton conductive resin.
Owner:JSR CORPORATIOON +1
Fluid circuits for sorbent cartridge with sensors
ActiveUS20140190885A1Cation exchanger materialsOrganic anion exchangersSorbentMechanical engineering
A system for measuring at least one fluid characteristic at various stages within a sorbent system that has a sorbent cartridge that has at least one material layer and at least one fluid passageway in at least one location in the sorbent system to provide a diverted sample stream from the various stages. At least one fluid characteristic of the diverted sample stream is measured.
Owner:MOZARC MEDICAL US LLC
Antibody purification
ActiveUS7385040B2Ion-exchange process apparatusChromatographic cation exchangersPresent methodProtein C
The present invention relates to a method of separating antibodies from contaminants in a solution, which method comprises contacting the solution with a chromatography resin comprised of a support to which multi-modal ligands have been immobilised, wherein a multi-modal ligand comprises at least one cation-exchanging group and at least one aromatic or heteroaromatic ring system. In one embodiment, the ring-forming atoms of the aromatic or hereoaromatic entity are selected among C, S or O, and the cation exchanging group is a weak cation exchanger. The present method may be used as a single step procedure or as a polishing step following a capture on a Protein A column.
Owner:CYTIVA BIOPROCESS R&D AB
Process for producing coarse-particle anion-exchanger gels
InactiveUS6924317B2Improve stabilityHigh purityCation exchanger materialsIon-exchanger regenerationChemistryFeeding procedures
The present invention relates to a process for producing monodisperse anion-exchanger gels with high stability, purity and coarse particle size greater than 800 μm starting from a monodisperse bead polymer with a swelling index of from 2.5 to 7.5 and more than one subsequent feed procedure without any separation between the polymerization steps and then modifying to give the anion exchanger.
Owner:LANXESS DEUTDCHLAND GMBH
Method for preparing strong acidic ion-exchange fibers
ActiveCN104499281AImprove mechanical propertiesImprove hydrophilicityCation exchanger materialsFibre typesCross-linkPolymer science
The invention provides a method for preparing strong acidic ion-exchange fibers. The method comprises the steps of performing vacuum packaging for polyolefine fibers; pre-irradiating through a radiation source; feeding pre-irradiated polyolefine fibers into a grafting solution under the protection of inert gas to react to obtain a polyolefine fiber grafting copolymer; then sulphonating through chlorosulfonic acid to obtain strong acidic ion-exchange fibers; a cross-linking agent is fed into the grafting solution to enable high mechanical strength and relatively high exchange capacity of the sulphonated fibers. According to the method, the process is simple, the polyolefine fiber grafting copolymer is easily prepared under a low temperature condition; the prepared polyolefine fiber-styrene copolymer is low in styrene autopolymer (less than 2%); the dichloroethane solution of chlorosulfonic acid is treated as a sulphonating agent, so that little chlorosulfonic acid is used, and the post-processing is simple.
Owner:SHENZHEN QIANHAI ZHONGSHENG ENVIRONMENTAL PROTECTION TECH
Chromatography method and a column material useful in said method
InactiveUS6884345B1Chromatographic cation exchangersCation exchanger materialsNatural sourceStationary phase
A novel sorbent suitable for use as a stationary phase in a chromatography column, the core of which consists of an organic polymer of synthetic or natural origin. Further, the carrier exhibits a plurality of covalently bonded non-aromatic zwitterionic groups on its surface. Additionally, the invention also relates to a method for purifying a particular biological macromolecule, such as a protein or a nucleic acid, by zwitterionic ion exchange chromatography as well as an ion exchange column suitable for use in the zwitterionic ion exchange chromatography.
Owner:MERCK PATENT GMBH
Filtration media coated with zero-valent metals, their process of making, and use
The present invention generally relates to filtration media for treating fluids, particularly water. In one aspect, the invention relates to the filtration media coated with nano-sized, zero-valent metals. In another aspect, this invention relates to the processes for making such nano-sized, zero-valent metal-coated filtration media. In yet another aspect, the invention relates to removing microbiological impurities such as microbial pathogens from water by treating the water with filtration media that include nano-sized zero-valent metals. In another aspect, the invention relates to a device comprising such nano-sized, zero-valent metal-coated filtration media for treating water.
Owner:UNIVERSITY OF DELAWARE
Metal-air cell with ion exchange material
Embodiments of the invention are related to anion exchange membranes used in electrochemical metal-air cells in which the membranes function as the electrolyte material, or are used in conjunction with electrolytes such as ionic liquid electrolytes.
Owner:FORM ENERGY INC
Protein purification
InactiveUS20120065381A1Improve conductivityCation exchanger materialsOrganic anion exchangersIon chromatographyMulti pollutant
A method for purifying a polypeptide by ion exchange chromatography is described in which a gradient wash is used to resolve a polypeptide of interest from one or more contaminants.
Owner:GENENTECH INC
Protein purification
ActiveUS8044017B2Improve conductivityPowder deliveryCation exchanger materialsIon chromatographyMulti pollutant
A method for purifying a polypeptide by ion exchange chromatography is described in which a gradient wash is used to resolve a polypeptide of interest from one or more contaminants.
Owner:GENENTECH INC
Highly durable polymer electrolytic membrane for a fuel cell having a cross-linked structure
InactiveUS20060134493A1Wide rangeGood dimensional stabilityCation exchanger materialsIon-exchanger regenerationCross-linkFunctional monomer
The objective of the invention is to solve the problems of conventional polymer electrolyte membranes, including small ion-exchange capacity and low oxidation and methanol resistance. A polymer film substrate is irradiated with γ-rays, electron beams or other radiations to perform multi-graft polymerization with functional monomers and then the polymer film substrate containing the grafted molecular chains or the graft molecular chains into which sulfonic acid groups have been introduced is crosslinked by irradiation to produce a polymer electrolyte membrane that has outstanding oxidation resistance, dimensional stability, electrical conductivity and methanol resistance and which can be controlled in ion-exchange capacity over a wide range.
Owner:JAPAN ATOMIC ENERGY AGENCY INDEPENDANT ADMINISTRATIVE CORP +1
Method of separating components in a sample using silane-treated silica filter media
The present invention provides methods for separating one or more components of interest from a sample containing particulates and soluble materials. The method comprises the steps of: (a) filtering a sample through silica filter media whose surface silanol groups have reacted with one or more silanes, and (b) simultaneously capturing particulates and binding a soluble component to the silica filter media. The bound soluble component of interest is subsequently eluted from the silica filter media. In one embodiment of the invention, unwanted soluble materials are captured by the treated silica filter media and desired component of interest is recovered from the flow-through. In another embodiment of the invention, different components of interest are recovered from both the eluate and the flow-through. Preferred treated silica filter media are silane-treated rice hull ash or diatomaceous earth with functional quaternary ammonium group or functional sulphonate group. Particulates suitable for the present invention, for example, are microorganisms.
Owner:DOW CORNING CORP
Coated ion exchanged substrate and method of forming
ActiveUS7291395B2Promote formationEasy to synthesizeChromatographic cation exchangersLiquid surface applicatorsIon exchangeAminal
A method for making an ion exchange coating (e.g., a chromatographic medium) on a substrate comprising (a) reacting at least a first amine compound comprising amino groups, with at least a first polyfunctional compound, in the presence of a substrate to form a first condensation polymer reaction product, with a first unreacted excess of either at least said first amino group or polyfunctional compound functional moieties, irreversibly attached to the substrate, and (b) reacting at least a second amine compound or at least a second polyfunctional compound with unreacted excess in the first condensation polymer reaction product to form a second condensation polymer reaction product, and repeating the steps to produce the desired coating. A coated ion exchange substrate so made.
Owner:DIONEX CORP
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