665results about "Cation exchanger materials" patented technology

The present invention provides a positively charged microporous membrane having a protein binding capacity about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.

A method of removing organic iodides from non-aqueous organic media includes contacting the organic media with a silver or mercury-exchanged cationic ion exchange substrate at a temperature greater than about 50° C. The method is particularly effective for removing high molecular weight organic iodides from organic media such as acetic acid or acetic anhydride. Particular species removed include decyl iodides and dodecyl iodides from organic media such as acetic acid.

PCT No. PCT/SE97/00237 Sec. 371 Date Dec. 29, 1998 Sec. 102(e) Date Dec. 29, 1998 PCT Filed Feb. 14, 1997 PCT Pub. No. WO97/29825 PCT Pub. Date Aug. 21, 1997Process for separating off a peptide or a nucleic acid by an anion exchanger (I) characterized in that a) the anion exchanger (I) exhibits ligands, which (i) contain a primary, secondary or tertiary amino group and (ii) are covalently bound to an organic polymer (matrix), b) there on a carbon atom at a distance of 2 or 3 atoms away from an amino nitrogen in the ligands is a hydroxyl group or a primary, secondary or tertiary amino group, and c) the maximum elution ionic strength in the pH range 2-14 for at least one of the proteins transferrin, ovalbumin 1, ovalbumin 2, beta -lactoglobulin 1 and beta -lactoglobulin 2 on the anion exchanger is higher than the elution ionic strength required for a quaternary comparative ion exchanger.

A sorbent based monitoring system for measuring the solute concentration of at least one component of a fluid. The system has a sorbent regeneration system for regeneration of the fluid and has a sorbent cartridge that has at least one material layer. The fluid is conveyed through the sorbent cartridge and contacts at least one sensor after having contacted at least one material layer.

A blood based solute monitoring system for measuring at least one blood solute species that has a first recirculation flow path in fluid communication with a dialyzer. The first recirculation flow path is configured to allow a fluid to recirculate through a dialyzer such that the concentration of at least one solute species in the fluid becomes equilibrated to the solute species concentration of the blood in a blood compartment of the dialyzer. The blood solute monitoring system has at least one sensor to measure a fluid characteristic.

Methods and related apparatuses for sorbent recharging are provided. The methods and related apparatuses for recharging can recharge a specific rechargeable layer or module of a sorbent material such as zirconium phosphate in a sorbent cartridge. The methods and apparatuses include a fluid source containing at least one recharging fluid, wherein the fluid source is fluidly connectable to at least one rechargeable sorbent module for use in sorbent dialysis in a fluid flow path. The methods and apparatuses include passing a single solution through the zirconium phosphate for ion exchanges, resulting in zirconium phosphate to maintain a substantially consistent pH in a dialysate used during dialysis.

The invention provides a proton conductive membrane excellent in heat resistance, which has sulfonic acid as ion exchange groups. The proton conductive membrane comprises a nitrogen-containing compound that can be mixed with water in arbitrary proportions and has a boiling point of not lower than 100. degree. C. and a proton conductive resin which has sulfonic acid ion-exchange groups, wherein the nitrogen-containing compound is contained in an amount of 0.5 to 10 parts by weight based on 100 parts by weight of the proton conductive resin.

A system for measuring at least one fluid characteristic at various stages within a sorbent system that has a sorbent cartridge that has at least one material layer and at least one fluid passageway in at least one location in the sorbent system to provide a diverted sample stream from the various stages. At least one fluid characteristic of the diverted sample stream is measured.

The present invention relates to a process for producing monodisperse anion-exchanger gels with high stability, purity and coarse particle size greater than 800 μm starting from a monodisperse bead polymer with a swelling index of from 2.5 to 7.5 and more than one subsequent feed procedure without any separation between the polymerization steps and then modifying to give the anion exchanger.

The invention provides a method for preparing strong acidic ion-exchange fibers. The method comprises the steps of performing vacuum packaging for polyolefine fibers; pre-irradiating through a radiation source; feeding pre-irradiated polyolefine fibers into a grafting solution under the protection of inert gas to react to obtain a polyolefine fiber grafting copolymer; then sulphonating through chlorosulfonic acid to obtain strong acidic ion-exchange fibers; a cross-linking agent is fed into the grafting solution to enable high mechanical strength and relatively high exchange capacity of the sulphonated fibers. According to the method, the process is simple, the polyolefine fiber grafting copolymer is easily prepared under a low temperature condition; the prepared polyolefine fiber-styrene copolymer is low in styrene autopolymer (less than 2%); the dichloroethane solution of chlorosulfonic acid is treated as a sulphonating agent, so that little chlorosulfonic acid is used, and the post-processing is simple.

A method for purifying a polypeptide by ion exchange chromatography is described in which a gradient wash is used to resolve a polypeptide of interest from one or more contaminants.

The objective of the invention is to solve the problems of conventional polymer electrolyte membranes, including small ion-exchange capacity and low oxidation and methanol resistance. A polymer film substrate is irradiated with γ-rays, electron beams or other radiations to perform multi-graft polymerization with functional monomers and then the polymer film substrate containing the grafted molecular chains or the graft molecular chains into which sulfonic acid groups have been introduced is crosslinked by irradiation to produce a polymer electrolyte membrane that has outstanding oxidation resistance, dimensional stability, electrical conductivity and methanol resistance and which can be controlled in ion-exchange capacity over a wide range.

The present invention provides methods for separating one or more components of interest from a sample containing particulates and soluble materials. The method comprises the steps of: (a) filtering a sample through silica filter media whose surface silanol groups have reacted with one or more silanes, and (b) simultaneously capturing particulates and binding a soluble component to the silica filter media. The bound soluble component of interest is subsequently eluted from the silica filter media. In one embodiment of the invention, unwanted soluble materials are captured by the treated silica filter media and desired component of interest is recovered from the flow-through. In another embodiment of the invention, different components of interest are recovered from both the eluate and the flow-through. Preferred treated silica filter media are silane-treated rice hull ash or diatomaceous earth with functional quaternary ammonium group or functional sulphonate group. Particulates suitable for the present invention, for example, are microorganisms.

The invention relates to a system and a process for fractionating a solution into two or more fractions. The system of the invention comprises at least two compartments having a diameter of at least about one meter and including a uniform packing of a polymer-based ion exchange resin with a bead size in the range of about 50 to about 250 mum. The mixing volume of the fluid fronts in the system of the invention is not more than 5% of the volume of the compartment.

An improved process for preparing anion exchange resins based on the use of a non-agitated plug-flow quench procedure followed by recycle of a portion of the recovered chloromethylation reaction fluids into subsequent chloromethylation reactions is disclosed. The combination of plug-flow hydration, providing highly concentrated recovered sulfuric acid, together with the recycle or reuse of the recovered concentrated sulfuric acid, allows for reduced raw material requirements during anion exchange resin manufacture and reduces the environmental impact of waste sulfuric acid processing.

The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are high purity chromatographic materials comprising a chromatographic surface wherein the chromatographic surface comprises a hydrophobic surface group and one or more ionizable modifier.

An cross-linked anion exchange resin or a salt thereof obtained by reacting a polymer (A) having amino and/or imino groups in the total number of two or more per molecule with a compound (B) having two or more functional groups capable of reacting with amino and/or imino group contained in the polymer (A). The resin or salt has a water absorption ratio of 4.0 or lower.

This invention relates to functional nonwoven filter media provided by radiation-induced graft copolymerization and its production method. Meltblown type of nonwoven (Meltblown) comprised of fine fibers, less than 8 micron in diameter, of polyolefin or polyamide is chosen as the suitable grafting trunk polymer. The production methods are composed of following steps, 1) irradiation less than 30 kGy dose to the Meltblown with electron beam or gamma ray; 2) graft copolymerization of emulsified vinyl monomer onto the Meltblown; and 3) chemical conversion of ion exchange group onto the grafted vinyl monomer. These steps are independently conducted in their suitable operation conditions.

The present invention provides a process for preparing a functionalised polymeric chromatography medium, which process comprises (I) providing two or more non-woven sheets stacked one on top of the other, each said sheet comprising one or more polymer nanofibres, (II) simultaneously heating and pressing the stack of sheets to fuse points of contact between the nanofibres of adjacent sheets, and (III) contacting the pressed and heated product with a reagent which functionalises the product of step (II) as a chromatography medium.

The present invention relates to a method of isolating a target compound from other components of a liquid, which method comprises at least two chromatographic steps, in any sequence of order, wherein the mobile phase is contacted with an affinity chromatography matrix and/or an ion-exchange chromatography matrix and/or a hydrophobic interaction chromatography matrix, wherein the contacting with at least one of the matrices takes place in the presence of at least one non-ionic polyether; and obtaining the target compound(s) in a separate fraction from the last chromatographic step. In the most preferred embodiment, the non-ionic polyether is poly(ethylene glycol) (PEG).

The invention provides novel methods for the separation of charged molecules such as proteins according to the isoelectric points (pI's) and includes the systems and buffering compositions employed for isolating charged molecules. The invention further provides for modifications to the above described chromatographic methods that enable the separation of charged molecules exhibiting virtually identical pI's by shifting both the buffer's pKa and the pI's of the eluted charged molecules while they are traversing the ion exchange column.

The invention discloses organic pollution resistance ion exchange resin, and a preparation method and an application of the resin, and belongs to the technical field of improving performances of the ion exchange resin. During preparation of the ion exchange resin, an inorganic particle which is wrapped with a modifier and is equivalent to 0.1-30% of mass of the resin is added to increase a water content of the resin by 3-30%, so that a resin structure is improved, and the regeneration efficiency of the resin is improved by 0.4-70%. The organic pollution resistance of the ion exchange resin in the water treatment application can be improved, the service life of the ion exchange resin is prolonged, the ion exchange resin can be regenerated and used stably for a long term in the water treatment application, ensure a water treatment effect and avoid complicated operation and cost pressure caused by frequent resin replacement, and the method is simple, effective and low in cost.

An ion exchange composition membrane is made up of dispersed natural clay and/or organized clay in ion conducting polymeric film as a methanol barrier material. The membrane exhibits low methanol crossover, high proton conductivity and is thus suitable for use in direct methanol fuel cells with low costal advantage.

The invention relates to chromatographic separating materials having improved binding capacity for biological constituents in cell culture supernatants, or animal or human body fluids, in particular for monoclonal antibodies. The present invention likewise relates to the preparation of separating materials of this type, and to the use thereof, in particular for the removal of charged biopolymers from corresponding liquids.

Binderless BaKX zeolitic adsorbents, methods for their production, and processes for their use in a liquid phase adsorptive separation process are provided. An adsorbent includes a binder-converted zeolite portion formed from x wt % kaolin clay binder and (100-x) wt % unconverted Zeolite X with a silica:alumina molar ratio of about 2.5. The kaolin clay binder is in the range of about 10 to about 20 wt %. Ba and K occupy cationic exchangeable sites within the adsorbent. K is in the range of about 0.25 to about 0.9% by weight and Ba is greater than about 31.6% by weight of the binderless BaKX zeolitic adsorbent. Cornstarch may be added to the Zeolite X and kaolin clay binder to increase adsorbent macro-porosity and pore volume. Productivity of the adsorbent is improved decreasing process operating costs. The mechanical strength of the adsorbent is also improved.

The invention discloses an acid modified palygorskite-polyurethane porous material as well as a preparation method and an application thereof, belonging to the technical field of synthesis of inorganic-organic materials. According to the preparation method of the acid modified palygorskite-polyurethane porous material, palygorskite is modified for preparing acid modified palygorskite, polybasic alcohol, foaming agent, a foaming stabilizer, water and a catalyst are added, mixed and uniformly stirred, then diisocyanate is added for mixing and foaming at a temperature of 50-70 DEG C, and finally the mixture is subjected to aging at the temperature of 90-105 DEG C for 1-2 hours, and after being cooled, the acid modified palygorskite-polyurethane porous material is obtained. Aiming to the characteristics of rich reserves, low cost, non-abrasion property, high chemical stability, large specific surface area and the like of palygorskite, the preparation method of acid modified palygorskite-polyurethane porous material via foaming by one step is provided. Additionally, by the adoption of the prepared acid modified palygorskite-polyurethane porous material in the absorption of cationic dye, the operation is simple, the cost is low, the absorption rate is high, and the use value is higher.

To provide a reinforced electrolyte membrane to which breakage such as cracking is less likely to occur at the time of handling the reinforced electrolyte membrane during a period between after production of the reinforced electrolyte membrane and before conditioning operation of alkali chloride electrolysis, or at the time of disposing the reinforced electrolyte membrane in an electrolytic cell at the time of conditioning operation, and a process for producing the same.

A reinforced electrolyte membrane 1 having an electrolyte membrane 10 containing a fluoropolymer having ion exchange groups, reinforced by a woven fabric 20 made of a reinforcing thread 22 and a sacrificial thread 24, wherein

• • the sacrificial thread 24 remains in the electrolyte membrane 10,
  • a void is formed between the sacrificial thread 24 and the electrolyte membrane 10, and
  • 2000 μm²<A<600 μm² and 0.3≦B/A<1.0 are satisfied, wherein A is the total of a cross-sectional area of the sacrificial thread 24 and a cross-sectional area of the void, and B is the cross-sectional area of the sacrificial thread 24.

The invention discloses a preparation method for macroporous weak-acidic cation exchange resin, which comprises the following steps of: carrying out suspension polymerization in a calcium chloride aqueous solution by using acrylic acid to partially substitute for methyl acrylate and acrylonitrile and by using toluene and gasoline as pore forming agents, washing with water after polymerization, washing with methanol to remove the pore forming agents, and hydrolyzing in a NaOH aqueous solution to obtain the macroporous weak-acidic cation exchange resin. The macroporous weak-acidic cation exchange resin prepared by the preparation method provided by the invention has a weak acid exchange capability higher than 11 mmol/g and is pure white. The preparation method provided by the invention has the advantages of no need for hydrolysis to remove alcohol groups, low cost of acrylic acid, simple process, recyclable water phase calcium chloride aqueous solution, low cost, low environmental pollution, etc.

The invention provides ion exchange and electrochemical methods and devices employing anion exchange polymers produced by substantially simultaneous quaternization and polymerization reactions. Anion selective polymers are produced in accordance with the invention by combining, an ethylenic tertiary amine monomer, an alkylating agent having a boiling point temperature of at least about 100° C., and a cross-linking agent in the presence of a polymerizing agent for a time and at a temperature sufficient to form the polymer. The alkylating agent and the cross-linking agent may be the same compound, a cross-linking alkylating agent. The polymers may be produced in the presence of solvents and/or in the presence of diluting monomers which are incorporated into the polymers.

The invention provides methods for treating a fluid, particularly water, contaminated with organic compounds, organisms, toxic substances, hazardous substances, ammonia, or mixtures thereof, by adsorption with an adsorbent material and regeneration of the purified adsorbent material. The contaminants may be first adsorbed onto the adsorbent material, which is then regenerated by treatment with nanoparticles of at least one transition metal oxide catalyst and at least one oxidant; or the contaminants are adsorbed onto particles of the adsorbent material loaded with at least one transition metal oxide, which is then regenerated by treatment with an oxidant; or the contaminated fluid is treated with an oxidant first and then with particles of the adsorbent material loaded with at least one transition metal oxide. The adsorbed contaminants are converted into environmentally compatible products.