38 results about "Dialysate regeneration" patented technology

A combination of acid zirconium phosphate and alkaline hydrous zirconium oxide are utilized as ion-exchange materials, for example, in sorbent dialysis. The combination provides for dialysate regeneration while maintaining constant and controlled levels of Na+, HCO3−, and pH.

The present invention is directed to degassing devices for dialysate circuits. One embodiment has a first housing and a second housing positioned within the first housing in an annular relationship. A second embodiment comprises a dialysate regeneration system with urease, a dialyzer, and a housing with an external wall, where the external wall is exposed to atmosphere and comprises a material that passes gas but does not pass liquid and where the housing is positioned between the urease and dialyzer.

The present invention is directed to degassing devices for dialysate circuits. One embodiment has a first housing and a second housing positioned within the first housing in an annular relationship. A second embodiment comprises a dialysate regeneration system with urease, a dialyzer, and a housing with an external wall, where the external wall is exposed to atmosphere and comprises a material that passes gas but does not pass liquid and where the housing is positioned between the urease and dialyzer.

Systems and methods for managing the potassium concentration of a dialysate fluid during hemodialysis therapy using cation exchange materials that do not release sodium ions.

A combination of acid zirconium phosphate and alkaline hydrous zirconium oxide are utilized as ion-exchange materials, for example, in sorbent dialysis. The combination provides for dialysate regeneration while maintaining constant and controlled levels of Na+, HCO3−, and pH.

A customizable modular dialysate regeneration assembly with connectable sorbent packaging systems. The dialysate regeneration assembly can be customized based on patient parameters or dialysis session parameters. A processor can be included that can determine the correct amount of each sorbent material necessary for a given patient and a given dialysis session.

Systems and methods of generating and regenerating peritoneal dialysate are provided. The systems and methods use a dialysate regeneration module, a sterilization module and concentrates to prepare peritoneal dialysate from used peritoneal dialysate or source water. An optional integrated cycler for direct infusion of the generated peritoneal dialysate is included. Optional dialysate storage containers are provided for storage of the peritoneal dialysate prior to use.

A dialysate regeneration system for removing contaminants from spent dialysate according to this invention includes a dialysate circulation flow path including a pump that pumps spent dialysate through the dialysate circulation flow path, a first cartridge adapted to remove contaminants from the spent dialysate, including a first cleaning solution inlet and a first cleaning solution outlet, a second cartridge adapted to remove urea from the spent dialysate, the second cartridge including semi-permeable hollow fibers adapted for transport of urea across the walls of the semi-permeable hollow fibers and adapted to retain at least calcium, magnesium, and sodium ions in the spent dialysate, and including a second cleaning solution inlet and a second cleaning solution outlet. Ancillary to the two cartridges, the dialysate regeneration system further includes a first dialysate cleaning flow path including a pump that pumps first cleaning solution from the first cleaning solution outlet of the first cartridge through a first cleaning stage to the first cleaning solution inlet of the first cartridge, and a second dialysate cleaning flow path including a pump that pumps second cleaning solution from the second cleaning solution outlet of the second cartridge through a second cleaning stage to the second cleaning solution inlet of the second cartridge.

A dialysis apparatus for treating a patient with liver and / or kidney disease. In one embodiment a liver dialysis apparatus comprises an artificial liver. The artificial liver comprises a blood compartment, a vegetable protein compartment, and a clear dialysis compartment. In another embodiment the liver dialysis apparatus comprises cartridge made up of at least one layer of vegetable protein. In a further embodiment of the invention a dialysate regeneration device is provided which comprises at least one layer of vegetable protein. The vegetable protein is preferably a soy protein. The soy protein may be unmodified soy protein with urease enzyme activity, modified soy protein with or without urease activity, alone or in combination.

The present invention relates to a dialysate regeneration device capable of continuously regenerating dialyzate in a dialysis treatment process, or regenerating the dialysate after dialysis, which can greatly reduce the amount of dialysate and clean water used in the dialysate process, The dialysate regeneration device is particularly suitable for dialysate in an emergent condition. The dialysate regeneration device comprises a pump, a reverse osmosis component, an electric catalysis reactor based on BDD electrode and a dialysate water tank. An upstream of the reverse osmosis component is communicated with a liquid outlet of a dialysis machine via the pump; the downstream of the reverse osmosis component comprises two branches, one branch (concentrated water) converges the other branch (clean water) through two groups of electric catalysis reactors and is communicated with a liquid inlet of the dialysate water tank via the confluence port ; a liquid outlet of the dialysate water tank is communicated with the liquid inlet of the dialyzate machine; a filter and air emission component are arranged on a communication channel between the outlet of the electric catalysis reactors and the confluence port.

A dialysis apparatus for treating a patient with liver and / or kidney disease. In one embodiment a liver dialysis apparatus comprises an artificial liver. The artificial liver comprises a blood compartment, a vegetable protein compartment, and a clear dialysis compartment. In another embodiment the liver dialysis apparatus comprises cartridge made up of at least one layer of vegetable protein. In a further embodiment of the invention a dialysate regeneration device is provided which comprises at least one layer of vegetable protein. The vegetable protein is preferably a soy protein. The soy protein may be unmodified soy protein with urease enzyme activity, modified soy protein with or without urease activity, alone or in combination.

Systems and methods are provided for performing selective sorbent-based regeneration of dialysate. The systems and method provide for dialysate regeneration to be carried out intermittently throughout a dialysis session, decreasing the necessary amounts of sorbent materials and infusates to conduct dialysis. The system and methods allow for regeneration of dialysate as needed based on the concentration of waste species in the dialysate, allowing for effective treatment with a decreased need for sorbent materials.

The invention discloses a preparation method of active carbon with a high specific surface area made from bamboo wood, and belongs to the technical field of resource comprehensive utilization. The method comprises the steps that the abandoned bamboo wood is cleaned, aired, carbonized, then subjected to furnace cooling, broken into certain granularity, dried, and packaged for use; KOH and a carbonized material are mixed uniformly, put in a ceramic crucible and placed in a microwave device; nitrogen is introduced to a furnace to exhaust air in the furnace; heating with microwaves is performed; in the last few minutes of the heating, CO2 is blown in quickly through a conduit communicated with the bottom of the ceramic crucible, and an ultrasonic generator is started simultaneously; after the heating, water washing with tap water is performed and residual KOH is recovered; washing is performed repeatedly with an appropriate amount of hydrochloric acid; cleansing with the tap water and drying are performed; and the active carbon with the high specific surface area made from the bamboo wood is obtained. The active carbon produced by the method is high in specific surface area, high in adsorption capacity, and lower in ash content, has well-developed pores, and can be applied in the medical fields of blood purification, dialysate regeneration and the like after appropriate disinfection and refining.

Systems and methods for managing the potassium concentration of a dialysate fluid during hemodialysis therapy using cation exchange materials that do not release sodium ions.

The present invention relates to a dialysis machine for the purification of blood, a manifold for the dialysis machine as well as to a process for the regeneration of the dialysis bath. It is an object of the present invention to provide a dialysis machine, a manifold for the dialysis machine as well a process which facilitates the administration of medical preparations during a dialysis procedure. In order to solve the object, a dialysis machine according to the present invention comprises tubes (1, 5, 8) connected with a dialyzer (6), means for delivering pharmaceuticals into the tubes and a pump (11) for the transport of blood through the tubes and the dialyzer. The dialysis machine comprises means for administration (4) of at least one pharmaceutical by a suction effect of the pump or by a pressure effect of the pump or by an excess pressure of a gas or a liquid.

The invention relates to a sorbent for removing metabolic waste products from a dialysis liquid, the sorbent comprising a soluble source of sodium ions. The sorbent comprises an ion exchange system which converts urea to ammonium ions and which is configured to exchange ammonium ions for predominantly hydrogen ions and to exchange Ca, Mg, and K for predominantly sodium ions. The soluble source ofsodium ions overcomes an initial drop in sodium concentration in regenerated dialysate. When used in conjunction with an infusion system configured to utilise exchange of Ca, Mg and K for sodium during dialysate regeneration a desired sodium ion concentration can be maintained.

The invention relates to the field of blood purifying equipment, and discloses a dialyzate regenerating device and a blood purifying system. The dialyzate regenerating device comprises a first flow pump, a purifying unit, a liquid storage pot, a second flow pump and an outer cavity of a dialyzer which communicate with each other through pipelines to form a circulating loop, wherein an ion concentration adjusting unit and an acid-base balance adjusting unit are further arranged on the pipeline between the purifying unit and the liquid storage pot; an electrolyte adjusting unit is further connected on the pipeline between the output end of the liquid storage pot and the inlet of the outer cavity of the dialyzer; and a sensor group used for detecting the ionic concentration, the pH value and the amount of liquid in the liquid storage pot is arranged in the liquid storage pot. For the dialyzate regenerating device and the blood purifying system provided by the invention, the recycling of the dialyzate can be realized, the use amount of dialyzate in the dialysis process is greatly reduced, the dialysis cost is reduced, the integral size of the dialysis device is reduced, the carrying is convenient, and due to the modular design, the system can realize various functions.

A patient wearable, continuously operating extracorporeal pump apparatus which accesses the patient's arterial venous pressure differential by applying external pressure to a subcutaneous graft that has been cannualized to modulate blood flow through an extracorporeal circuit and to drive the pump for delivering a medicament, such as an anticoagulant, to the site of an intravenous cannula to prevent clogging thereof and also to move a dialysate through a circuit, including a dialyzer and a dialysate rejuvenating cartridge, whereby kidney failure can be treated without recourse to prior art hemodialysis machines found in most treatment facilities. With slight modification, the present invention can be used to remove excess fluids from CHF patients, to remove toxins from the blood in those suffering from liver failure and to facilitate administration of insulin to diabetics and / or glucose to those having hypoglycemia.

Provided is a temperature-based dialysate regeneration device for regulating a temperature of dialysate discharged from a hemodialyzer to remove uremic toxins and waste therefrom, the temperature-based dialysate regeneration device including: a Joule-Thomson refrigerator, including a compressor, condenser, expander and evaporator, an adsorbent column, and a dialysate heat exchanger in which heat transfer occurs between dialysates. The refrigerant used for the JT refrigerator may be a mixture of two or more refrigerants to enhance the heat transfer generated by the latent heat in the evaporator and the condenser.

The invention relates to a blood extracorporeal circulation life support system. The system comprises a blood circulation subsystem and a dialysis circulation subsystem; blood of the living body enters the blood circulation subsystem through a blood outlet of the living body via a circulation pipeline to be circulated and then flows back to the living body through a blood inlet of the living bodyvia the circulation pipeline; the blood sequentially passes through a first blood pump, a first toxin removing device, a hemodialysis device, a feeding device and an oxygenation device in the blood circulation subsystem; and the dialysis circulation subsystem exchanges substances with the blood circulation subsystem through the hemodialysis device, and dialysate in the dialysis circulation subsystem flows back to the hemodialysis device through a water balance device, a first pump body, a second toxin removing device, an ion adjusting device and a temperature adjusting device in sequence afterflowing out of the hemodialysis device. By means of the system, dialysate regeneration and blood purification are conducted at the same time, and the size and operation difficulty of the blood extracorporeal circulation life support system are greatly reduced.

The invention discloses a core-shell structured heparinoid microsphere based on graphene oxide grafted urease, and a preparation method and applications of the core-shell structured heparinoid microsphere. According to the preparation method, a graphene oxide two-dimensional nanosheet layer is taken as a base material, immobilizing urease on the surface of the base material by carbodiimide methodso as to obtain a core solution; in-situ cross-linking polymerization is adopted to prepare a heparinoid polymer solution to obtain a shell solution; and reverse-forward phase inversion method is adopted to obtain the core-shell structured heparinoid microsphere. The core-shell structured heparinoid microsphere is capable of removing urea with high efficiency in hemoperfusion, relieving patient pain, and can also be used for dialysate regeneration in hemodialysis, and provide technical support for a wearable artificial kidney.

The invention provides a method and an apparatus or system for dialysis. The method and apparatus or system are useful for removing an undesirable protein-binding substance such as a toxin from a biological fluid such as blood or blood plasma. As such, the method and apparatus or system are useful for treating a subject in need of dialysis such as a subject suffering from hepatic disease. The methods feature a) dialyzing a biological fluid against a dialysis fluid containing an adsorber for a protein-binding substance to be removed through a semipermeable membrane, b) adjusting the dialysis fluid so that the binding affinity of the adsorber for the protein-bound substance to be removed is lowered and the substance to be removed passes into solution, and c) balancing the volume or flow of one or more fluids in the apparatus or system suitable for dialyzing a biological fluid containing a protein-binding substance to be removed. The apparatus or system features a) a biological fluid circuit (3); b) a dialysis fluid circuit (2); c) a means (4; 6; 7; 8; 9) for solubilizing the protein-binding substance to be removed; d) a dialysis, filtration or diafiltration device (5); e) a balancing system or apparatus suitable for balancing the volume or flow of one or more fluids in the apparatus or system suitable for dialyzing a biological fluid containing a protein-binding substance to be removed; and f) a dialysate regeneration unit.

Systems and methods are provided for performing selective sorbent-based regeneration of dialysate. The systems and method provide for dialysate regeneration to be carried out intermittently throughout a dialysis session, decreasing the necessary amounts of sorbent materials and infusates to conduct dialysis. The system and methods allow for regeneration of dialysate as needed based on the concentration of waste species in the dialysate, allowing for effective treatment with a decreased need for sorbent materials.

The invention discloses a dialysate regeneration method and a blood purification system. A porous adsorbing material is utilized to conduct adsorption treatment on dialysate, the influence on dialysate components is small, a complicated acid-base and ion regulating control system is avoided, the regenerated dialysate can be cyclically used for hematodialysis or peritoneal dialysis or other blood purification, and various blood purification modes are achieved. Due to the simple technical scheme, the whole size and weight of a dialysis device are greatly decreased, and wearable or portable treatment can be achieved.

Systems and methods of generating and regenerating peritoneal dialysate are provided. The systems and methods use a dialysate regeneration module (104), a sterilization module (107, 121), and concentrates (105) to prepare peritoneal dialysate from used peritoneal dialysate or source water (102). An optional integrated cycler for direct infusion of the generated peritoneal dialysate is included. Optional dialysate storage containers are provided for storage of the peritoneal dialysate prior to use.

The invention provides a method and an apparatus or system for dialysis. The method and apparatus or system are useful for removing an undesirable protein-binding substance such as a toxin from a biological fluid such as blood or blood plasma. As such, the method and apparatus or system are useful for treating a subject in need of dialysis such as a subject suffering from hepatic disease. The methods feature a) dialyzing a biological fluid against a dialysis fluid containing an adsorber for a protein-binding substance to be removed through a semipermeable membrane, b) adjusting the dialysis fluid so that the binding affinity of the adsorber for the protein-bound substance to be removed is lowered and the substance to be removed passes into solution, and c) balancing the volume or flow of one or more fluids in the apparatus or system suitable for dialyzing a biological fluid containing a protein-binding substance to be removed. The apparatus or system features a) a biological fluid circuit (3); b) a dialysis fluid circuit (2); c) a means (4; 6; 7; 8; 9) for solubilizing the protein-binding substance to be removed; d) a dialysis, filtration or diafiltration device (5); e) a balancing system or apparatus suitable for balancing the volume or flow of one or more fluids in the apparatus or system suitable for dialyzing a biological fluid containing a protein-binding substance to be removed; and f) a dialysate regeneration unit.

The invention relates to microporous activated carbon for urea adsorption and a preparation method and application thereof. The microporous activated carbon is prepared from an alkali metal compound activated carbon material or activated carbon, the specific surface area of the microporous activated carbon is greater than 1500m < 2 > / g, the specific surface area of micropores is greater than 500m< 2 > / g, the pore volume of the micropores is greater than 0.4 cm < 3 > / g, and the pore diameter of the micropores is 0.4-1.5 nm. The microporous activated carbon has high adsorption capacity on urea,the activated carbon can be used for adsorption of urea in a solution and a dialysate regeneration system, and the development of a mobile or wearable dialysis machine is greatly simplified.

A customizable modular dialysate regeneration assembly with connectable sorbent packaging systems. The dialysate regeneration assembly can be customized based on patient parameters or dialysis session parameters. A processor can be included that can determine the correct amount of each sorbent material necessary for a given patient and a given dialysis session.