The invention discloses an oxidation
chitosan graft modified porcine
dermal collagen micro-nano
fiber membrane and a preparation method thereof. The oxidation
chitosan graft modified porcine
dermal collagen micro-nano
fiber membrane is characterized in that the preparation method comprises the steps: by applying an electrostatic
spinning technology and using traceable purified porcine
dermis as a
raw material and hexafluoroisopropanol as a
solvent, stirring at 4-10 DEG C until the mixture is transparent, formulating to obtain electrostatic
spinning mother liquor with concentration of 0.5-10%, and directly
spinning to obtain the porcine
dermal collagen micro-nano
fiber membrane; then performing graft modification on the porcine dermal collagen micro-nano fiber membrane by using oxidation
chitosan, thereby finally obtaining the oxidation chitosan graft modified porcine dermal collagen micro-nano fiber membrane. A membrane material not only has good bio-compatibility, biodegradability and mechanical properties, but also has anti-oxidation effects, antibacterial activities, anti-
inflammation /
wound healing promotion effects, anti-
cancer / anti-tumor effects and antiviral effects of chitosan, is significantly better than a collagen
composite membrane material prepared by using collagen as the
raw material, and can be widely applied to the preparation of biomedical materials such as hemostatic materials,
tissue engineering scaffold materials, biological dressings and the like.