5 results about "Dermal collagen" patented technology

The present application relates to the technical field of in vitro detection, and particularly relates to a platelet aggregation function detection reagent and application thereof.The platelet aggregation function detection reagent provided by the present application comprises a fibrin activator and an ADP reagent, the fibrin activator adopts a novel high-purity porcine dermal collagen polypeptide component Prionex, and the combination with glycine significantly improves the stability of the fibrin activator, the platelet inhibitor tirofiban is used in combination with PEG6000, the accuracy of the detection result is improved, and the sensitivity to the anti-platelet aggregation drug is improved; the ADP reagent adopts chitosan, the activity and stability are improved, and the ADP reagent can be widely applied to clinical diagnosis of platelet aggregation function.

The application discloses a skin cosmetic method based on pulsed laser, comprising the following steps: S1, obtaining epidermal pigment distribution, dermal collagen density, wrinkle depth and abnormal vascular area through a spectrum confocal microscope and a VISIA skin analyzer; S2, performing epidermal pretreatment by using intense pulsed light, selecting a 500-600 nm or 600-1200 nm wave band according to the skin problem type, an energy density of 8-25 J / cm2 and a pulse width of 2-10 ms; S3, starting deep treatment of pulsed laser after 15-60 s interval; S4, monitoring blood oxygen saturation and melanin index of skin tissue in real time by using a spectrum reflectometer during treatment, and dynamically adjusting light source energy and pulse interval; S5, promoting epidermal repair by using a cold compress gel containing hyaluronic acid in cooperation with an ultrasonic introduction instrument after treatment; and S6, regularly performing curative effect evaluation. The application generates a personalized scheme through multi-dimensional skin detection, utilizes IPL to pretreat epidermal pigment and vascular problems, combines 755 nm / 1064 nm pulsed laser to stimulate collagen regeneration in a deep layer, and realizes collaborative treatment of the epidermis-dermis layer.

This invention belongs to the field of biomaterials technology, specifically relating to a highly safe and durable double-crosslinked yak type III collagen implant, its preparation method, and its applications. Using yak type III collagen as raw material, it self-assembles into type III collagen fibers, then crosslinks them using metal ions for coordination, followed by a secondary crosslinking with a chemical crosslinking agent. This process maintains the original triple helix structure and fibrotic characteristics of type III collagen, exhibiting good injectability, viscoelasticity, and anti-degradation capabilities. It also demonstrates excellent cell compatibility and cell activity, promoting fibroblast proliferation, migration, and adhesion, and regulating macrophage inflammation-related phenotypes. Furthermore, it can improve skin hydration, reduce transepidermal water loss, promote dermal collagen deposition and tissue structure reconstruction, without causing significant systemic toxicity or persistent local inflammatory reactions, effectively repairing photo-aged skin. It shows great application potential in the fields of photo-aged skin repair and related skin implant medical devices.

The invention relates to the technical field of cosmetic preparations, in particular to essence containing polypeptide and a polypeptide composition and a preparation method of the essence, and the essence comprises the following components: active peptide, polypeptide-phospholipid composite microcapsules, moisturizing and repairing components, antioxidant components, auxiliary materials, preservative components and a special skin-care active agent; the active peptide is prepared from acetyl hexapeptide-8, palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7; the polypeptide-phospholipid composite micro-capsule is formed by compounding active peptide and lecithin; the moisturizing and repairing component is prepared from tetrahydromethylpyrimidine carboxylic acid and acetylated sodium hyaluronate; the antioxidant components comprise bakuchiol and ergothioneine; the auxiliary materials comprise cross-linked povidone, polyethylene glycol and polyvinylpyrrolidone; the anti-corrosion component comprises phenoxyethanol and ethylhexylglycerin; the pH (Potential of Hydrogen) value of the essence composition is adjusted to 5.5 to 6.0. The method can comprehensively cope with key problems of skin layer thinning, corium layer collagen loss, free radical damage and the like.

The invention belongs to the technical field of skin care products, and particularly relates to neohesperidin nano-liposome, a sunscreen emulsion and a preparation method and application of the neohesperidin nano-liposome and the sunscreen emulsion. The neohesperidin nano-liposome provided by the invention is formed by wrapping neohesperidin in a lipid membrane, and in-vitro experiments prove that the emulsion containing the neohesperidin nano-liposome can significantly improve UVB-induced mouse skin light injury, and the skin presents a small amount of injury traces; skin swelling and corium layer thickening induced by UVB irradiation are reduced, corium collagenous fiber reduction caused by UVB irradiation is remarkably improved, and the relative content of collagenous fibers after neohesperidin acts is remarkably increased.