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Application of flavonoid quercetin in inhibition of skin scar formation and skin fibration

A quercetin and fibroblast technology, which is used in the preparation of reagents for inhibiting collagen deposition in a mouse dermal fibrosis model, and in the preparation of reagents for inhibiting skin scarring and/or skin fibrosis. Applications in scarring and skin fibrosis, the field of reagents for scarring in mice

Inactive Publication Date: 2014-11-05
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] But there is no report about the role of quercetin in inhibiting skin scar formation and skin fibrosis

Method used

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  • Application of flavonoid quercetin in inhibition of skin scar formation and skin fibration
  • Application of flavonoid quercetin in inhibition of skin scar formation and skin fibration
  • Application of flavonoid quercetin in inhibition of skin scar formation and skin fibration

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] 1. Experimental materials and methods

[0048] 1. Molecular physical and chemical properties of quercetin

[0049] The quercetin (CAS 117-39-5) molecule used in the experiment was purchased from Selleck (cat. no. S2391).

[0050] Drug penetration through the stratum corneum and epidermis into the dermis is the main route for drug absorption through the skin. To achieve transdermal absorption of drugs, the following requirements need to be met: the dose is small and the effect is strong; substances with a molecular weight greater than 600 are difficult to pass through the stratum corneum; organic weak acids or organic weak bases exist in molecular form and have greater transdermal penetration. Fat-soluble drugs have an ideal transdermal absorption effect, while ionic drugs are generally difficult to penetrate the stratum corneum. The molecular weight of quercetin is 302.24, and the structural formula is as follows Figure 1A , belongs to organic weakly acidic drugs,...

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PUM

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Abstract

The invention relates to an application of flavonoid quercetin in inhibition of skin scar formation and skin fibration. The application verifies that quercetin has no toxicity to fibroblast, human dermal fibroblast I / III-type collagen mRNA expression and protein synthesis can be inhibited by inhibiting a TGF beta1 signal pathway in cells, fibroblast can be inhibited to myofibroblast differentiation, so that skin scar formation or dermal collagen deposition (fibration) can be inhibited, Animal in-vitro experiment confirms that quercetin is effected on mice skin, bleomycin-induced mice skin fibration and tension force-induced mice skin scar formation can be inhibited. Because that quercetin has the characteristics of small molecular weight, high lipid solubility and good transdermal absorption capability, the molecules can be used for preparing the medicine for resisting skin scar formation and skin fibration, and have wide application prospect in medical, shaping and cosmetic fields.

Description

technical field [0001] The invention relates to a new medical application of the flavonoid compound quercetin, in particular to the application of the flavonoid compound quercetin in inhibiting skin scar formation and skin fibrosis. Background technique [0002] Scarring is one of the most common complications after wound healing. Scar formation affects the appearance of the patient, accompanied by itching and pain, and the resulting contracture can lead to different degrees of dysfunction, such as tendon contracture, joint dislocation, motor dysfunction, occupational psychological disorder, etc., which reduces the quality of life of the patient. Later treatment brings heavy economic and psychological burden. According to statistics, the incidence of hypertrophic scars after burns among Chinese people is 91.4%. If the burn wound healing time exceeds 2 weeks, the incidence of hypertrophic scars is as high as 74.67%, which is much higher than the 38.00% reported abroad. Th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P17/00A61P17/02A61K8/49A61Q19/00
Inventor 张艺凡李青峰
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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