141 results about "SKIN SCARRING" patented technology

A problem to be solved of the present invention is to provide a drug formulation and a method of administering an active ingredient which allow the active ingredient to be delivered evenly into the site of action in the skin with high efficiency while ensuring stability of the active ingredient over a long time, and which are easily handled and are less stressful for patients. Mean for solving the problem is a microneedle assembly formulation for skin treatment comprising a platform and a plurality of conical or pyramidal microneedles formed on the platform containing a base composed of a bio-soluble and thread-forming polymer substance and an objective substance retained in the base, wherein the objective substance is a substance effective for prevention or treatment of skin senescence, or treatment of skin scar.

The described invention provides methods and compositions utilizing a NELL1 peptide or nucleic acid encoding a NELL1 peptide for treating or preventing a skin condition. The methods include treating or preventing manifestations of aging in human skin, repairing damage to skin, and preventing skin scarring. Methods are also provided for assaying a test peptide for NELL1 activity.

The invention relates to minimally invasive bone harvesting equipment used for the treatment of spinal surgery and various orthopedic operations. The traditional bone harvesting operation causes big surgical trauma and an evident skin scar and the appearance is affected after a large bone is taken out. The minimally invasive bone equipment is a set of medical apparatus, which comprises a circuit-opening bone harvesting drill, a bone harvesting drill and an auxiliary bone harvesting drill. The invention also comprises an abrasion drill, a bone chisel, a spatula and a drag hook. The bone harvesting drill comprises a drill rod and a bone-pushing rod. The drill rod is a round rod provided with an inner bore that is a straight hole. The front end of the drill rod is provided with a cutting edge. The bone-pushing rod is the solid round rod sheathed in the inner bore. The bone harvesting drill, and the like, needs to be installed on an electric drill or a manual handle when in use. The minimally invasive bone harvesting equipment is applicable to taking out the bone manually or electrically and has easy and safe operation, which is the novel, safe, efficient and convenient minimally invasive bone harvesting equipment and the pathology biopsy equipment for sclerotin and marrow.

The invention discloses emulsion containing traditional Chinese medicine extracting solution and used for treating eczema and a preparation method thereof. According to the formula, the emulsion comprises sweet almond oil, calamine, evening primrose oil, comfrey infused oil, emu oil, a rhizoma chuanxiong extracting solution, a cortex phellodendri extracting solution, a radix sophorae flavescentis extracting solution, a rough gentian extracting solution, a cortex dictamni extracting solution, a common cnidium fruit extracting solution, a cell activating agent MG-60, water-soluble VE, glycerol, 1,2-propylene glycol, ethylparaben, sodium alginate, Creagel SC G57 and distilled water. Compared with the prior art, the emulsion is gentle in medicine property and high in safety. Active substances in natural traditional Chinese medicine are adopted for promoting healthy growth of skin, the normal barrier function of the skin is restored, inflammatory cells can be inhibited, the emulsion is antibacterial and can expel toxin, superficial cells of the skin are adjusted, and elasticity of the skin is restored; the emulsion further has the functions of calming down the nerves and relieving itching, eliminating redness and swollenness, relaxing the skin surface layer and relieving skin scars and has the curative effect of remarkably relieving eczema.

The invention discloses application of hemp extract or cannabidiol in skin scar removing, and also discloses application of the hemp extract or cannabidiol in preparation of medicines or cosmetics removing skin scars, and application of the hemp extract or cannabidiol in preparation of medicines or cosmetics suppressing tyrosinase activity and promoting fibrocyte proliferation.

The invention discloses a compound having a structure represented by formula (I) and used for a discoidin domain receptor micro-molecule inhibitor, or its pharmaceutically acceptable salt or stereo isomer or prodrug molecule. The above compounds can effectively inhibit the activity of the discoidin domain receptor, and can be used for preparing drugs for preventing and treating inflammations, liver fibration, kidney fibration, lung fibration, skin scars or atherosclerosis.

The invention provides an itching-relieving scar-removing coating agent which comprises a filming material, an aromatic agent as well as a penetration enhancer, a plasticizing agent, a pH adjusting agent and a preservative. The itching-relieving scar-removing coating agent has a rapid itching-relieving and swelling-removing function on mosquito bite and can be also used for removing skin scars.

The invention relates to a skin scar diagnosis method based on secondary harmonic image texture analysis. The method comprises the following steps: classifying to-be-treated images into a training set and a test set and transforming the images into gray images; encoding the gray images in an LD-LBP (Local Difference-Local Binary Pattern) way to obtain an LD-LBP code image and a variance V1; performing Haar wavelet transformation on the LD-LBP code image, calculating a low-frequency sub-band coefficient average value ULL, a variance Var, an energy ratio Er and a level sub-band coefficient average value VLH; forming a characteristic vector by use of V1, ULL, Var, Er and ULH and performing gaussian normalization on the characteristic vector; performing a fuzzy K-Nearest neighbor algorithm on the normalized characteristic vector; outputting the category of the test set. The method can be used for achieving non-destructive diagnosis on skin scars and is excellent in identification effect and diagnosis capability, and can be used for solving the destructive problem of scar diagnosis in the prior art and assisting doctors in judging the category of scars and selecting a reasonable therapy method.

The invention provides plastic silica gel attached on a skin scar. The plastic silica gel comprises at least two material layers, wherein a first material layer is made of a silica gel main body material and is in direct contact with skin; a second material layer is made of a structural material and used for forming and fixing the shape of the silica gel main body material, and the first material layer is attached onto the second material layer. The invention also provides a production method of the plastic silica gel used for preventing and intervening the scar and scar proliferation. The plastic silica gel used for preventing and intervening the scar and scar proliferation adopts a thermoplastic polyester material as a medical splint material for the silica gel main body material, can be softened after being heated to a certain temperature, can form the required shape at will and can keep and fix the formed shape after being cooled, so that silica gel clings to the skin scar, and good prevention and treatment effects on the scar and scar proliferation are realized.

The present invention provides a composition for correcting scar of skin which corrects a scar of skin such as a mark of skin injury, which achieves an excellent effect of correcting a scar of skin with a good covering ability and an ease in applying the composition repeatedly or another thereover and has a good feeling in use as well as an excellent long-lasting effect in makeup. The composition comprises (a) 30 to 50% by mass of titanium oxide and (b) 2 to 20% by mass of coating agents including acrylic-silicone graft copolymer and siliconated polysaccharide compound.

The invention discloses a preparation method of novel tissue engineering skin. The method includes steps of jointly culturing an amniotic membrane decellularized scaffold and a mesenchymal stem cell to be a carrier, inoculating horn cell; culturing by a serum-free culturing system, and acquiring a complete tissue engineering skin membrane. Through the method, the method can culture a complete skin membrane and the skin membrane can be applied to the skin scar repair and leucoderma treatment. The horn cell is originated from body skin or prepuce of the newborn. The carrier is low in immunogenicity while also has biological activity; the serum-free culturing system can realize the in-vitro serum-free cultivation and amplification of the horn cell, and improve cell growth, multiplication, cell form, activity and function instead of bad influence; the skin membrane cultivated by the method is approached to natural skin; after the skin-grafting culturing, it can be applied to the scar repair of scaled and other injured skins as well as treatment of skin disease such as leucoderma.

The invention discloses a plant glucomannan silicone dressing. The plant glucomannan silicone dressing is prepared from the following components in percentage by weight: 0.05-5 percent of plant glucomannan, 0.5-50 percent of silicone, 0.1-5 percent of organosilicon antibacterial agent and the balance of matrix. A preparation method of the plant glucomannan silicone dressing comprises the following steps: mixing the plant glucomannan, the silicone and the organosilicon antibacterial agent and dissolving in the matrix; sterilizing and disinfecting through irradiation to prepare a finished product. By using the plant glucomannan silicone dressing, scars can be obviously reduced or prevented from hyperplasia and softening, the color tends to be consistent with the color of surrounding skin, the symptoms of itching and pain are obviously relieved, and the congestion condition is obviously improved, so that the plant glucomannan silicone dressing can be used for inhibiting formation of early skin scars and reducing the mid-term scar hyperplasia and hardness and pigmentation of later scars, and the feelings of itching and pain of scar tissues can be effectively relieved.

This invention provides methods of preventing formation of, or treating, fibrotic lesions, including skin scars such as keloids and hypertrophic scars which comprise administering to the subject by one or more injection a compound which comprises a modified oligonucleotide, such as a modified antisense oligonucleotide, siRNA, or oligodeoxyribonucleotide, which inhibits expression of protein involved in fibrosis. Dosing of the antisense using an intradermal threading technique is also described.

The invention relates to a dendrobe extract and application of the dendrobe extract and belongs to the technical field of pharmacy. The dendrobe extract is obtained by the following method that a, dendrobe is cut into pieces by scissors and water is then added for boiling according to the proportion that the W / V(weight / volume) is 1:(10-20), the boiling is continuously maintained for 2 to 4 hours after the dendrobe is boiled in the water, the filtering is carried out, residual slag is removed, and extraction liquid is collected; b, the step a is repeated for 2 to 4 times, the extraction liquid in each time is combined, and powdery dendrobe water extracts are obtained through freeze drying; c, the dendrobe water extracts obtained in the step b are uniformly mixed with the water to be prepared into dendrobe water extract solution with the concentration being 5Mu g / ml-100Mu g / ml; and d, or the dendrobe water extracts obtained in the step b are uniformly mixed with vaseline to be prepared into dendrobe water extract paste with the W / W (weight / weight) concentration being 0.02 percent-2 percent. The dendrobe extract is applied to the preparation of medicine for promoting the skin scar tissue repair. The dendrobe extract and the application have the beneficial effects that the scar tissue formation can be obviously reduced by the dendrobe, the application prospect of preparation of the medicine for promoting the skin scar tissue repair is shown, and a new application field is developed for the dendrobe.

The invention discloses an ointment for treating skin scars, which is prepared from safflower, sinkiang arnebia root, Chinese angelica, dark plum fruit, chalcanthite, Chinese gall, centipede, dragon's blood, honey and vinegar serving as raw material medicaments by the conventional process. The ointment has the effects of promoting blood circulation by removing blood stasis, softening hard lumps, dispelling nodes and eliminating scars, is suitable for all patients with scars, and can minify and soften large skin scars and eliminate small scars for the skin scars caused by various reasons so as to recover partial function. Clinical curative effect observation indicates that the total effective rate of the ointment is 93.8 percent.

The invention discloses applications of TRADD (Tumor necrosis factor receptor associated death domain protein) gene over-expressed lentivirus for inhibiting formation of skin scars or treating skin scars, and particularly discloses a preparation method of the TRADD gene over-expressed lentivirus. The TRADD gene over-expressed lentivirus can simultaneously improve the smoothness and color uniformity of the skin scars.

The invention concerns compounds, compositions and methods for the treatment of skin cells. Described herein are CD109 polypeptides and uses thereof for the in vivo treatment of various skin disorders, including skin fibrosis, skin scarring, wound healing and psoriasis.

The invention discloses a seed melon extract and a cosmetic comprising the same. The seed melon extract is obtained through the following method: (1) removing seeds from a mature seed melon, crushing melon pulp or the melon pulp with skin, extracting at 25-75 DEG C by using a volume concentration of 75-85%, filtering to obtain supernatant; (2) extracting the supernatant obtained in the step (1) at room temperature by using normal butanol, and condensing the extractive matter under vacuum to obtain paste; and (3) adding water into the paste at 25-50 DEG C, dissolving the paste, filtering, collecting filtrate, condensing under vacuum, and drying to obtain the seed melon extract. The seed melon extract can be used for cosmetic additives, such as human body liquid cleaning products, hair care products or skin care products. The cosmetic of the invention is nutritive, preserves moisture for the skin of human body, and is capable of promoting skin metabolism, improving skin scars, inhibiting pigmentation and resisting aging. After the cosmetic is used, the skin is obviously soft and smooth.

The present invention relates to an external application western medicine composition preparation with functions of scar treatment, anti-inflammation, itching relieving and pain relieving, and an application thereof. The external application western medicine composition preparation comprises a medicine active ingredient and a pharmaceutically acceptable auxiliary material, wherein the medicine active ingredient mainly comprises 3-10% of acetylsalicylic acid and 8-15% of captopril. According to the present invention, the conventional preparation process is adopted to prepare different external application formulations in the clinic; pharmacodynamics experiment results show that: skin wound fibroblast proliferation is significantly inhibited, collagen fiber content is reduced, skin growth is promoted, and effects of anti-inflammation, itching relieving and pain relieving are provided; and the external application western medicine composition preparation has characteristics of synergetic effect of the compound medicine, significant treatment effect, low price and simple preparation, is a safe and effective skin scar treatment medicine, and has broad application prospects.

Provided is a dermal scar treatment equipment. The treatment equipment includes a pad, a plurality of pins, and an insulating layer. The pad electrically connects with a high frequency generator. The pins are protrusively coupled to a front of the pad, are inserted into collagen fibers in the dermis through the epidermis, and propagate a high frequency to the collagen fibers. The insulating layer is coated on an end of each of the pins and isolates the pins from the epidermis for no contact.

The invention provides a preparation method of fibroblasts for skin scar repair, wherein the method comprises the steps of extracting fibroblasts from tissues and culturing with a fibroblast growth factor, vitamin E, phosphoric acid-3-O-rutinoside and L-lactic acid to obtain the fibroblasts. The prepared fibroblasts have good biological activity, repair broken fibrous tissues, restore a collagen structure of a skin basal layer, and also inhibit fibrosis and scar formation caused by overexpression of collagen; and the fibroblasts provided by the invention have good therapeutic and cosmetic effects on skin scars.

The invention belongs to the technical field of treating skin scars, and particularly relates to a breathable itching-relieving antisepsis scar treating paster and a preparation method thereof. The technical problem to be solved is to provide a new choice for treating a hypertrophic scar. According to the technical scheme, the breathable itching-relieving antisepsis scar treating paster is prepared from the following active ingredients in percentage by weight: 97.9% of silicone, 1% of mint, 1% of borneol, 0.05% of heparin sodium, and 0.05% of nanosilver. The invention further provides a preparation method for the breathable itching-relieving antisepsis scar treating paster. The treating paster provides a new choice for treating the scar.

The present invention provides a composition for preventing skin scars. The composition comprises onion exosomes. The composition for preventing the skin scars further comprises one or more of an active component, a pH adjusting component, a moisturizing component, a stabilizing component and a preservative component. The composition for preventing the skin scars has good scar prevention and relieving effects.

It is to provide an agent for preventing and treating skin aging, or an agent for treating skin scar that can exert a sufficient effect. An agent for preventing and treating skin aging comprising bFGF for treating aging of the skin that is administered intradermally or subcutaneously, or an agent for treating skin scar comprising bFGF for treating scar of skin that is administered intradermally or subcutaneously is utilized. Preferred examples of aging of skin include skin wrinkle, pigmented spot, sagging skin, rough skin, skin thinning, decrease of skin viscoelasticity, etc., and preferred examples of scar include keloid, hypertrophic scar, scar contracture, etc.

Crystalline pyridone compound, which is the white needle crystal containing no water and other crystallization solvents. Its unit cell belongs to monoclinic system and has space group of P21 / n, wherein a=3.8512(2), b=20.2535(12), c=12.1628(6) Å, β=92.850(5)° and crystal cell volume V=947.53(9) Å3. Pyridone compound crystal of this form has the needed properties for preparing or making treatment compositions in large scale. It can be used for treating organs fibrosis of liver, kidney, lung and etc. and reducing skin scars.

The present invention relates to a Chinese medicine prescription of compound centipede poultice which is used to externally remedy the cicatrical tissue proliferation of wounded skin. The Chinese medicine prescription uses 1 to 10 centipedes, 30 to 90g of nutgall, 10 to 30g of rhubarb, 10 to 30g of safflower and 10 to 30g of liquorice. The material is doubled when large dosage is needed. Dried and crushed to powder, the five Chinese medicines pass 100 mesh sieve and then is mixed and sealed for reserve. After cleaning, sterilizing and drying the wounded skin, the compound centipede powder is made into paste with 75 percent of alcohol in an abacterial porcelain jar. The user can use an abacterial cotton bud to dip the compound centipede powder and smear on the surface of the wounded skin evenly about 4 to 5 mm with a range larger than the wounded skin. Abacterial PE preservative film covers the paste surface. The wounded skin is covered and bound up according to different wounded part. The medicine should be changed for once to twice every day and for 1 to 3 weeks according to different wound situations. During the treatment time, the user should observe the curative effect.