20 results about "Bioactive composite" patented technology

The invention provides a DNA tetrahedron-based compound as well as a preparation method and application thereof, and belongs to the field of medicines. The invention designs a bioactive composite hydrogel scaffold modified by a functionalized DNA tetrahedron compound containing BMP-2, and the functionalized BMP-2 binding peptide is stably combined with a tetrahedron framework structure with a unique three-dimensional space structure and fine programmability in a chemical click mode. And further preparing with methacrylated hyaluronic acid to obtain the composite hydrogel stent. The functional DNA tetrahedron compound can efficiently capture BMP-2, the composite hydrogel scaffold can capture endogenous BMP-2 in a targeting manner in the early stage of bone defect and stimulate stem cell osteogenic differentiation so as to promote in-situ osteogenesis, a series of complications caused by delivery of exogenous bone morphogenetic protein-2 are avoided, the in-vivo stability is poor, and the in-vivo bone morphogenetic protein-2 can be used for preparing the bone morphogenetic engineering scaffold. The method has the advantages of high safety, high cost and the like, and has a good application prospect.

The invention relates to the technical field of medical instruments, in particular to a variable-diameter blood seepage prevention artificial blood vessel based on a multi-layer composite structure, which comprises a composite artificial blood vessel main body, and a bioactive composite layer is arranged on the outer side of a gradient pore polyester woven layer. The main body of the composite artificial blood vessel is composed of more units such as the first artificial blood vessel part, the second artificial blood vessel part, the third artificial blood vessel part and the fourth artificial blood vessel part, and the inner diameter difference between every two adjacent units is 2.0 mm, so that the variable-diameter structure is more suitable for natural blood vessels of people clinically; in addition, the bioactive composite layer comprises type I collagen, heparin sodium and VEGF sustained release microspheres, the collagen / heparin composite layer forms a hydrated gel barrier when in contact with blood, the errhysis volume is reduced to 1 / 16 of that of a traditional product, endothelial cell migration is promoted by utilizing TiOnanotube array layer and VEGF sustained release synergy, and in addition, under the pulsating pressure of 120 mmHg, through 1 million times of cycle tests, the effective rate of the collagen / heparin composite layer is greatly increased. The structural integrity retention rate is larger than 99%, and the mechanical fatigue resistance is high.

The application provides a DNA tetrahedron-based complex and a preparation method and application thereof, and belongs to the field of medicines. The application designs a functionalized DNA tetrahedron complex modified bioactive composite hydrogel scaffold containing BMP-2, combines the functionalized BMP-2 binding peptide with the tetrahedron framework structure with unique three-dimensional spatial structure and fine programmability through a chemical clicking mode, and further prepares the composite hydrogel scaffold by combining with methacrylated hyaluronic acid. The functionalized DNA tetrahedron complex realizes the performance of efficiently capturing BMP-2, and the composite hydrogel scaffold realizes the targeted capture of endogenous BMP-2 in the early stage of bone defect and stimulates the osteogenic differentiation of stem cells to promote in-situ osteogenesis, avoids a series of complications caused by the delivery of exogenous bone morphogenetic protein-2, and solves the problems of poor in-vivo stability, safety and high cost, and has a good application prospect.

This invention belongs to the field of foot and ankle joint replacement implant technology, and discloses an ankle joint talus prosthesis with an antibacterial porous interface and its preparation method. It includes a prosthesis substrate with an overall anatomically contoured structure, including a superior articular surface, a inferior articular surface, and an anterior articular surface; the area of ​​the prosthesis substrate in contact with residual bone tissue is designed as a three-dimensional porous structure; an antibacterial bioactive composite coating is grown in situ on the surface of the prosthesis substrate; it includes calcium and phosphorus bioactive components and antibacterial ions. This invention, by constructing an antibacterial bioactive composite coating at a porous bone integration interface, utilizes biocompatibility and osteoconductivity to induce bone tissue growth. Furthermore, the antibacterial ions can be slowly and continuously released in the interstitial spaces, achieving a dual function of promoting bone integration and preventing infection. Moreover, the antibacterial bioactive composite coating is formed through in-situ growth, resulting in a strong bond with the substrate and preventing detachment.

The invention relates to an extraction method of a bioactive composite peptide and application of the bioactive composite peptide in cosmetics. The composite peptide comprises peptide fragments with 20 specific amino acid sequences and precursor proteins derived from 12 genes, the total relative content is 63.82%, and the collagen related sequence accounts for 22%. A papain digestion combined ultrafiltration purification technology is adopted for extraction, the molecular weight is smaller than 2 kDa, and skin and hair barriers can be conveniently penetrated. The peptide fragments synergistically promote fibroblast activity, extracellular matrix construction and protein folding, are suitable for skin care and hair care products, and realize anti-aging, repair and damaged hair quality improvement. The scheme provided by the invention is clear in component, efficient in extraction and relatively low in cost.

This invention relates to bioactive composites, and more particularly, to bone void filler compositions including bioactive composites and / or implants and methods for the promotion of bone growth and regeneration. This invention also relates to bone void fillers, specifically to a high-strength calcium acrylic modified polymer (CAMP) material designed for orthopedic and surgical applications requiring both structural support and enhanced biological properties.

The application discloses a kind of tetragonal phase zirconium oxide / HA nano array bioactive composite coatings grown on zirconium alloy surface and method, belong to zirconium alloy surface treatment technical field, with Zr-2.5Nb alloy as anode, with pulse power constant voltage mode in containing calcium, phosphorus alkaline electrolyte Micro-arc oxidation reaction is carried out, voltage is 300-500V, Ca, P porous calcium stable tetragonal phase ZrO2 coating containing is generated on the surface of Zr-2.5Nb alloy, in 60-140 ℃ alkaline solution First hydrothermal reaction is carried out, then in containing calcium, phosphorus 60-140 ℃ alkaline mixed solution Second hydrothermal reaction is carried out, HA nano array bioactive coating is uniformly grown on the surface of tetragonal phase zirconium oxide coating, can effectively realize the modification to Zr-2.5Nb alloy surface, reach the purpose of promoting its bone integration ability and improving material mechanical property.

The present disclosure relates to medical implant components comprising a layer of biocompatible-bioactive composite, methods of making and uses thereof; the biocompatible-bioactive composite layer BACL comprises a component (a): a biocompatible metal or alloy, a biocompatible ceramic, or any mixture thereof, and a component (b): an organic bioactive ingredient.

The invention discloses a tetragonal-phase zirconia / HA nano-array bioactive composite coating growing on the surface of zirconium alloy and a method, and belongs to the technical field of zirconium alloy surface treatment, Zr-2. 5Nb alloy is used as an anode, micro-arc oxidation reaction is performed in alkaline electrolyte containing calcium and phosphorus in a pulse power supply constant voltage mode, the voltage is 300-500 V, and the reaction time is 30-60 min; a porous calcium-stabilized tetragonal phase ZrO2 coating containing Ca and P is generated on the surface of the Zr-2. 5Nb alloy, a first hydrothermal reaction is carried out in an alkaline solution at 60-140 DEG C, then a second hydrothermal reaction is carried out in an alkaline mixed solution containing calcium and phosphorus at 60-140 DEG C, and the HA nano-array bioactive coating uniformly grows on the surface of the tetragonal phase ZrO2 coating. The surface of the Zr-2. 5Nb alloy can be effectively modified, and the purposes of promoting the osseointegration capacity and improving the mechanical property of the material are achieved.

The invention discloses degradable bioactive composite bone cement and a preparation process thereof, and relates to the technical field of biological materials, and the preparation process comprises the following process steps: preparing a CMC solution, adding recombinant I collagen, mixing and dissolving; adding BCP double-phase microsphere powder, and uniformly stirring; finally, adding a cross-linking agent to obtain a mixed solution; and reacting to obtain the degradable bioactive composite bone cement, and the cross-linking agent is NHS and EDC. Through component and process design, recombinant I-type collagen, CMC and BCP biphasic microsphere powder are used as raw materials and dissolved with water for injection, NHS and EDC are used as cross-linking agents, and the composite bone cement which is good in stability, mechanical property, plasticity, biocompatibility and bone conduction performance, degradable, easy to operate and injectable is prepared.

The disclosure relates to high-strength polyolefin composite fibers, which fibers have a fiber body comprising a composition consisting of polyolefin; 1-30 mass % of bioceramic particles having particle size D50 of 0.01-10 μm; at most 0.05 mass % of residual spin solvent; optionally 0-3 mass % of other additives; and wherein the sum of a)-d) is 100 mass %; and which fibers have bioceramic particles exposed at their surface, and show bioactivity. The composite fibers based on a composition of polyolefin with bioceramic particles mixed therein show particles being exposed at the fiber surface by techniques like AFM and XPS, and although apparently only a relatively small amount of bioceramic particles is exposed at the fiber surface, this appears sufficient for effective interaction with their environment and stimulating a positive biological response as demonstrated by in vitro cell studies.The present disclosure also concerns a method of making the high-strength composite fibers via a gel spinning process, fibrous articles comprising said bioactive composite fibers. Further embodiments concern use of these fibrous articles as a component of a medical implant or as a medical implant, especially as permanent high-strength orthopedic implants for repairing bone fractures or torn ligaments or tendons. Other embodiments include medical devices or implants comprising said fibrous articles.

The invention discloses an X-ray bioactive protective agent and a preparation method thereof, and belongs to the field of biological medicine. The protective agent is composed of 10%-30% of a bioactive composite extract, 5%-15% of an antioxidant, 3%-10% of a cell protective agent, 1%-5% of a skin penetration enhancer, 0.5%-3% of a thickening agent, 0.1%-1% of a preservative and a solvent. The bioactive compound extract contains sea-buckthorn, roxburgh rose and aloe extract, and cooperates with an antioxidant and a cell protective agent to play a protection role. The preparation method comprises the following steps: extracting plant effective components, compounding, and mixing with other components according to a process. The protective agent can relieve X-ray damage from the biological activity level, has the advantages of being good in protective effect, high in safety, small in irritation, high in stability and the like, and is suitable for reducing damage of X-rays to human tissue and cells.

This invention belongs to the field of biomaterials technology, specifically relating to a bioactive scaffold, its preparation method, and its applications. This invention incorporates functionalized mesoporous silica nanoparticles loaded with aminoguanidine into the skin secretions of the giant salamander and polycaprolactone electrospun fibers to construct a bioactive composite scaffold (SPMA). This scaffold enables the sustained release of AG and osteogenic factors, effectively inhibiting free radical generation, AGEs toxicity, and inflammatory responses. Furthermore, it significantly improves the survival rate, osteogenic differentiation, and mineralization capacity of bone marrow mesenchymal stem cells in a high-glucose microenvironment. In vivo experiments further demonstrate that in a streptozotocin-induced diabetic mouse model of skull defects, the SPMA scaffold can alleviate local inflammation, promote angiogenesis, and significantly accelerate new bone formation and defect repair.

This invention discloses a bioactive composite gel dressing for skin scar repair that inhibits lactic acid production, belonging to the technical field of scar repair gel dressings. The gel dressing is obtained by mixing methacrylamide-modified hyaluronic acid, methacrylamide-modified carboxymethyl chitosan, and mesoporous polydopamine, followed by a cross-linking reaction initiated by a cross-linking monomer and a photoinitiator. The mesoporous polydopamine is loaded with berberine and resveratrol. The cross-linking monomer can gradually degrade in the weakly acidic, highly reactive oxygen species microenvironment of scars, achieving controlled release of active substances. The mesoporous polydopamine combines drug carrier and antioxidant functions; its three-dimensional porous network structure contains numerous carboxyl groups, providing a moist environment for the wound. The long-chain alkane structure of the cross-linking monomer enhances the compatibility and transdermal properties of hydrophobic drugs. The active substances berberine and resveratrol inhibit lactic acid production and abnormal fibroblast proliferation. This dressing has high biocompatibility, and its decomposition products can participate in skin protein synthesis and barrier repair.

Disclosed in the present application are a piezoelectric composite biomaterial, a manufacturing method therefor, and use thereof. The manufacturing method comprises: forming a polydimethylphenylamide (PDA) coating on the surfaces of a plurality of nano barium titanate (BT) particles to obtain a plurality of BT / PDA particles; distributing the plurality of BT / PDA particles to the surfaces of a plurality of beta tricalcium phosphate (beta-TCP) particles to form bioactive composite BTP particles; and hot-melt mixing the composite BTP particles with a polymer matrix to form a BTP polymer composite biomaterial. The present application enables the composite material to possess bioactivity and piezoelectricity, overcoming the problem of barium titanate agglomeration.

The invention discloses a bioactive composite gel dressing for skin scar repair and capable of inhibiting generation of lactic acid, and belongs to the technical field of scar repair gel dressings. The gel dressing is obtained by mixing methacrylamidated hyaluronic acid, methacrylamidated carboxymethyl chitosan and mesoporous polydopamine and then initiating a cross-linking reaction through a cross-linking monomer and a photoinitiator, and berberine and resveratrol are loaded on the mesoporous polydopamine. The cross-linking monomer can be gradually degraded in a micro-environment with weak acidity and high active oxygen of scars, so that the controllable release of active substances is realized; mesoporous polydopamine has the functions of a drug carrier and antioxidation, a three-dimensional porous network structure contains more carboxyl groups and can provide a moist environment for a wound surface, and a long-chain alkane structure of a cross-linking monomer can enhance the compatibility and transdermal performance of a hydrophobic drug. The active substances berberine and resveratrol can inhibit the generation of lactic acid and inhibit the abnormal proliferation of fibroblasts. The dressing is high in biocompatibility, and decomposition products can participate in skin protein synthesis and barrier repair.

This invention discloses an antibacterial and bioactive composite film layer on the surface of a zirconium-based amorphous alloy, its preparation method, and its application, belonging to the technical field of biomedical zirconium alloy coating materials. Hydroxyapatite nanoparticles and strontium are introduced into the micro-arc oxidation process. Hydroxyapatite (HA) possesses excellent osteoconductivity, osteointegration capacity, osteoinductive properties, and biocompatibility; strontium plays a unique role as a "bidirectional regulator of bone metabolism" in biomedical materials. Furthermore, the incorporation of Cu endows the micro-arc oxidation film layer with broad-spectrum and long-lasting antibacterial capabilities. This invention generates a composite film layer with both antibacterial and bioactive properties on the surface of a zirconium-based amorphous alloy through a single micro-arc oxidation step, enhancing its overall service performance in physiological environments.

A method of vital pulp therapy with a bioactive capping material. The method includes drilling into a pulp of a tooth having decay to form a hole, then excavating infected pulp from the hole. The bioactive capping material is prepared by mixing glass ionomer cement (GIC) and potassium nitrate (KNO3) with a solvent. The method further includes covering healthy pulp in the tooth with the bioactive capping material and curing the bioactive capping material to form a cured capping material. The bioactive capping material includes KNO3 in an amount of 1 to 10 percent by weight (wt. %) based on the weight of the capping material.

The preparation method comprises the following steps: dissolving 2-methylimidazole, Zn (NO3) 26H2O and Co (NO3) 26H2O in a DMF-methanol solution, fully reacting to obtain Co-ZIF-8, carrying out ultrasonic dispersion on the Co-ZIF-8, adding curcumin, stirring and centrifuging to obtain CMM-Co-ZIF-8, mixing a suspension of SA and absolute ethyl alcohol with a NaIO4 aqueous solution, carrying out ultrasonic dispersion, adding curcumin, stirring and centrifuging to obtain CMM-Co-ZIF-8, carrying out ultrasonic dispersion on the CMM-Co-ZIF-8, carrying out ultrasonic dispersion on the CMM-Co-ZIF-8, and carrying out ultrasonic dispersion on the CMM-Co-ZIF-8 to obtain the nano-particle-based multifunctional bioactive composite hydrogel. The preparation method comprises the following steps: carrying out a reaction in the dark at room temperature, adding ethylene glycol to terminate the reaction, standing in absolute ethyl alcohol for precipitation, and dialyzing in a dialysis bag to obtain OSA, carrying out a cross-linking reaction on OSA and CMCS to form a stable cross-linked structure, wrapping CMM-Co-ZIF-8 in the stable cross-linked structure to form CCZ-coated OSA / CMCS hydrogel, spraying tannic acid to the CCZ-coated OSA / CMCS hydrogel, and carrying out secondary enhancement to obtain the CCZ-coated OSA / CMCS hydrogel. The curcumin-loaded hydrogel CCZ-coated OSA / CMCS / TA with a double-crosslinked network structure is obtained, the prepared CCZ-coated OSA / CMCS / TA slowly controls the release rate of CMM-Co-ZIF-8, has good stability, reduces potential toxicity, achieves the synergistic treatment effect of resisting inflammation, bacteria and oxidation, and is applied to the field of biomedicine.

The invention relates to the technical field of medical instruments, and discloses a preparation method of cellulose-based bioactive filaments for wound repair, which comprises the following specific steps: step 1, preparing an alkali / urea / sodium zincate water solvent by using alkali (NaOH, KOH and LiOH), urea, thiourea and ZnO as raw materials, step 2, mixing cellulose and amino acid, and then heating to react for 10-120 minutes at 150-180 DEG C to obtain a reaction product; and 3, directly dissolving the reaction product in the step 2 into the alkali / urea / sodium zincate water solvent prepared in the step 1 at the dissolving temperature of-5 to 5 DEG C, then adding a mixed solution of a polysaccharide raw material, silver nitrate and chloroauric acid into the dissolved solution, standing for 8 to 18 hours at the temperature of 5 to 30 DEG C, and filtering to obtain the product. The cellulose-based chitosan / ZnO bioactive composite filament is prepared by a wet spinning one-step method, so that the antibacterial property, the cytocompatibility and the wound healing promoting effect of a dressing product produced by processes such as weaving subsequently can be greatly improved.