69 results about "Bioactive composite" patented technology

Disclosed herein are methods to create medical devices and implantable medical devices with an electrochemically engineered porous surface that contains one or more bioactive materials to form bioactive composite structures. The bioactive composite structures are prepared using electrochemical codeposition methods to create metallic layers with pores that can be loaded with bioactive materials. In one use, the implantable medical devices of the present invention include stents with bioactive composite structure coatings.

Disclosed herein are methods to create medical devices and medical devices including bioactive composite structures. The methods include using electroless and electrophoretic deposition and codeposition methods for providing implantable medical devices coated with bioactive composite structures. In one use, the implantable medical devices of the present invention include stents with bioactive composite structures.

One embodiment of the invention is directed to a method comprising providing an electrochemical solution comprising metal ions and a bioactive material such as bioactive molecules, and then contacting the electrochemical solution and a substrate. A bioactive composite structure is formed on the substrate using an electrochemical process, where the bioactive composite structure includes a metal matrix and the bioactive material within the metal matrix.

Biologically active composites containing calcium phosphate, more specifically beta-tri-calcium phosphate, and methods of preparing the same are disclosed herein. Also disclosed are methods of restoring an osseous void and complimentary kits for the disclosed composites.

The invention relates to a broad-spectrum bioactive composite foliar fertilizer and its preparation method. The preparation method of the broad-spectrum bioactive composite foliar fertilizer comprises: (by weight of solid substances) mixing 14.2% of potassium dihydrogen phosphate, 14.2% of urea, 17.7% of brown sugar, 30% of composite amino acid powder, 7.1% of salt, 9.1% of fulvic acid, 0.4% of sodium acetate, 0.2% of magnesium sulfate, 7.6% of trace elements, and molasses with a concentration of 2.5ml / L, a composite liquid strain of equivalent lactic acid bacteria, yeasts, actinomycetes, aspergilli and phosphorus bacteria and with a concentration of 10ml / L, as well as sterile water at a temperature of 35DEG C, and conducting microaerobic fermentation for 192-288h, then adding photosynthetic bacteria with a concentration of 1ml / L for stirring, leaving the mixture to 48-96h of illumination, then adjusting the PH value, thus obtaining a bioactive composite foliar fertilizer. The bioactive composite foliar fertilizer of the invention can promote crop photosynthesis, activate the activity of each enzyme, enhance disease prevention and antibacterial properties of plants, and improve the stress resistance of plants. Characterized by no pollution, no public hazard, lasting fertilizer effect, the fertilizer of the invention can strengthen seedlings, resist diseases, enhance output, improve agricultural product quality, and bring products to market about 7-15 days earlier, thus improving agricultural economic benefits.

Methods of preparing bioactive composites are described. Also described are methods of molding such composites. Shaped bodies comprising bioactive composites are further described.

Methods of preparing bioactive composites are described. Also described are methods of molding such composites. Shaped bodies comprising bioactive composites are further described.

The invention provides a method for preparing a bioactive composite film layer containing hydroxyapatite on a titanium metal surface. The method comprises the following steps: preparing an electrolytic solution containing hydroxyapatite firstly; then applying voltage to the titanium metal through a power supply for low-voltage deposition and differential arc oxidation treatment, wherein at the low-voltage deposition stage: the voltage is controlled at 30V-120V and the deposition time is 5-20 minutes, and at the differential arc oxidation stage: the voltage is controlled at 450V-600V, the deposition time is 10 minutes and the frequency of the power supply is 200kHz, and the duty ratio is 10%; and growing a layer of HA (hydroxyapatite)-TiO2 composite ceramic layer on the surface of a titanium metal test sample after low-voltage deposition and differential arc oxidation. The method has the beneficial effects that the ceramic layer containing HA particles is prepared on the titanium test sample in the electrolyte solution, the process that the HA particles are deposited on the titanium metal test sample surface is simplified, and the content of HA in the film layer is changed through regulating the content of HA in the electrolyte solution or the deposition voltage and time.

The present invention relates to a method of preparing a bioactive composite, the method comprising the steps of a) adding in a solid state a biocompatible polymer and a bioactive glass to an extruder to form an extrudable material; b) applying energy to the extrudable material to at least the melting temperature of the biocompatible polymer to melt mix the biocompatible polymer and bioactive glass; and c) extruding a bioactive composite.

The invention discloses a high-biological activity composite material for promoting bone regeneration repair and a preparation method thereof. The preparation method comprises the following steps of respectively weighing 2 to 20wt% of foreign ion-doped calcium silicate powder, 40 to 60wt% of alpha-calcined gypsum powder and 20 to 40wt% of a mixed liquid, mixing them, stirring the mixture to obtain uniform paste, and carrying out hydration of the uniform paste to obtain the high-biological activity composite material which is a self-curing material. The high-biological activity composite material has self-curing performance, injectable performance, high strength and rapid degradation performance. The preparation method has simple processes. The high-biological activity composite material has excellent biological activity and degradability and can be used for fast and complete regeneration repair of bone defects in bone tooth tissue, root canal filling and slow-release carriers of bone disease-treatment drugs.

An object of the present invention is to provide a method for producing bioactive composites having imparted thereto bioactivity, to thereby form and grow in vivo or in vitro a coating layer containing a calcium phosphate compound as the major component with a high adhesion strength on the surface of various types of porous substrates such as a porous shaped body comprising an organic polymer. The means for solving the problem is characterized by comprising at least (1) a step of immersing a porous substrate in a solution containing at least calcium ions and hydrogenphosphate ions, thereby distributing the solution to the inside of at least a part of the pores of the substrate, and (2) a step of depositing fine particles containing a calcium phosphate compound as the major component inside the pores into which the solution is introduced.

The invention provides a degradable bioactivity composite containing calcium phosphate and a preparation method thereof. The composite consists of calcium phosphate and a multiple amino acid polymer; wherein, the weight percentage of inorganic composition is not more than 50 percent and the residual substance is the multiple amino acid polymer which is formed by the polymerization of caprolactam and at least 5 other amino acids; wherein, the molar ratio of the caprolactam in the polymer is 40-90 percent and the respective molar ratio of other single amino acid is not less than 0.5 percent. During preparation, the caprolactam is mixed with all amino acids and dehydration is carried out under the protection of inert gases and stirring, and pre-polymerization composition reaction and polymerization reaction are respectively carried out at the temperature of 210-250DEG C, thus obtaining the composite. The indexes of the prepared material such as mechanic performance, degradation period and the like can be adjusted and controlled according to the use requirements.

The invention relates to a bioactive composite material for bones as well as a preparation method and application of the bioactive composite material, in particular to a composite material for bones, which is characterized by comprising a substrate of a biodegradable polymer, and the substrate further comprises magnesium silicide; and the biodegradable polymer can be degraded in an aqueous solution environment to generate is micromolecular organic acids. The special effect of magnesium silicide acting on bone injury parts is found for the first time, a biodegradable polymer substrate is degraded in a physiological environment to generate micromolecular organic acids, and the surrounding environment of a stent is slightly acidic, so that degradation of magnesium silicide can be triggered, controllable long-acting release of magnesium ions and silicon ions along with the degradation process of the stent is realized, and osteogenic activity is promoted; and meanwhile, implantation parts are adjusted to form a hypoxic microenvironment, and angiogenesis is promoted. The magnesium silicide-containing composite material for bones shows bioactivity for promoting osteogenesis and vascularization, and can realize effective bone defect repair.