8 results about "Bioactive composite" patented technology

This invention belongs to the field of foot and ankle joint replacement implant technology, and discloses an ankle joint talus prosthesis with an antibacterial porous interface and its preparation method. It includes a prosthesis substrate with an overall anatomically contoured structure, including a superior articular surface, a inferior articular surface, and an anterior articular surface; the area of ​​the prosthesis substrate in contact with residual bone tissue is designed as a three-dimensional porous structure; an antibacterial bioactive composite coating is grown in situ on the surface of the prosthesis substrate; it includes calcium and phosphorus bioactive components and antibacterial ions. This invention, by constructing an antibacterial bioactive composite coating at a porous bone integration interface, utilizes biocompatibility and osteoconductivity to induce bone tissue growth. Furthermore, the antibacterial ions can be slowly and continuously released in the interstitial spaces, achieving a dual function of promoting bone integration and preventing infection. Moreover, the antibacterial bioactive composite coating is formed through in-situ growth, resulting in a strong bond with the substrate and preventing detachment.

This invention relates to bioactive composites, and more particularly, to bone void filler compositions including bioactive composites and / or implants and methods for the promotion of bone growth and regeneration. This invention also relates to bone void fillers, specifically to a high-strength calcium acrylic modified polymer (CAMP) material designed for orthopedic and surgical applications requiring both structural support and enhanced biological properties.

The invention discloses an X-ray bioactive protective agent and a preparation method thereof, and belongs to the field of biological medicine. The protective agent is composed of 10%-30% of a bioactive composite extract, 5%-15% of an antioxidant, 3%-10% of a cell protective agent, 1%-5% of a skin penetration enhancer, 0.5%-3% of a thickening agent, 0.1%-1% of a preservative and a solvent. The bioactive compound extract contains sea-buckthorn, roxburgh rose and aloe extract, and cooperates with an antioxidant and a cell protective agent to play a protection role. The preparation method comprises the following steps: extracting plant effective components, compounding, and mixing with other components according to a process. The protective agent can relieve X-ray damage from the biological activity level, has the advantages of being good in protective effect, high in safety, small in irritation, high in stability and the like, and is suitable for reducing damage of X-rays to human tissue and cells.

This invention belongs to the field of biomaterials technology, specifically relating to a bioactive scaffold, its preparation method, and its applications. This invention incorporates functionalized mesoporous silica nanoparticles loaded with aminoguanidine into the skin secretions of the giant salamander and polycaprolactone electrospun fibers to construct a bioactive composite scaffold (SPMA). This scaffold enables the sustained release of AG and osteogenic factors, effectively inhibiting free radical generation, AGEs toxicity, and inflammatory responses. Furthermore, it significantly improves the survival rate, osteogenic differentiation, and mineralization capacity of bone marrow mesenchymal stem cells in a high-glucose microenvironment. In vivo experiments further demonstrate that in a streptozotocin-induced diabetic mouse model of skull defects, the SPMA scaffold can alleviate local inflammation, promote angiogenesis, and significantly accelerate new bone formation and defect repair.

This invention discloses a bioactive composite gel dressing for skin scar repair that inhibits lactic acid production, belonging to the technical field of scar repair gel dressings. The gel dressing is obtained by mixing methacrylamide-modified hyaluronic acid, methacrylamide-modified carboxymethyl chitosan, and mesoporous polydopamine, followed by a cross-linking reaction initiated by a cross-linking monomer and a photoinitiator. The mesoporous polydopamine is loaded with berberine and resveratrol. The cross-linking monomer can gradually degrade in the weakly acidic, highly reactive oxygen species microenvironment of scars, achieving controlled release of active substances. The mesoporous polydopamine combines drug carrier and antioxidant functions; its three-dimensional porous network structure contains numerous carboxyl groups, providing a moist environment for the wound. The long-chain alkane structure of the cross-linking monomer enhances the compatibility and transdermal properties of hydrophobic drugs. The active substances berberine and resveratrol inhibit lactic acid production and abnormal fibroblast proliferation. This dressing has high biocompatibility, and its decomposition products can participate in skin protein synthesis and barrier repair.

Disclosed in the present application are a piezoelectric composite biomaterial, a manufacturing method therefor, and use thereof. The manufacturing method comprises: forming a polydimethylphenylamide (PDA) coating on the surfaces of a plurality of nano barium titanate (BT) particles to obtain a plurality of BT / PDA particles; distributing the plurality of BT / PDA particles to the surfaces of a plurality of beta tricalcium phosphate (beta-TCP) particles to form bioactive composite BTP particles; and hot-melt mixing the composite BTP particles with a polymer matrix to form a BTP polymer composite biomaterial. The present application enables the composite material to possess bioactivity and piezoelectricity, overcoming the problem of barium titanate agglomeration.

This invention discloses an antibacterial and bioactive composite film layer on the surface of a zirconium-based amorphous alloy, its preparation method, and its application, belonging to the technical field of biomedical zirconium alloy coating materials. Hydroxyapatite nanoparticles and strontium are introduced into the micro-arc oxidation process. Hydroxyapatite (HA) possesses excellent osteoconductivity, osteointegration capacity, osteoinductive properties, and biocompatibility; strontium plays a unique role as a "bidirectional regulator of bone metabolism" in biomedical materials. Furthermore, the incorporation of Cu endows the micro-arc oxidation film layer with broad-spectrum and long-lasting antibacterial capabilities. This invention generates a composite film layer with both antibacterial and bioactive properties on the surface of a zirconium-based amorphous alloy through a single micro-arc oxidation step, enhancing its overall service performance in physiological environments.

A method of vital pulp therapy with a bioactive capping material. The method includes drilling into a pulp of a tooth having decay to form a hole, then excavating infected pulp from the hole. The bioactive capping material is prepared by mixing glass ionomer cement (GIC) and potassium nitrate (KNO3) with a solvent. The method further includes covering healthy pulp in the tooth with the bioactive capping material and curing the bioactive capping material to form a cured capping material. The bioactive capping material includes KNO3 in an amount of 1 to 10 percent by weight (wt. %) based on the weight of the capping material.