577 results about "Bone Injury" patented technology

The invention relates to apparatus and method for ultrasonically and electromagnetically treating tissue to treat, for example, traumatized tissue or a bone injury. The apparatus includes at least one ultrasonic transducer assembly and at least one electromagnetic coil-assembly configured to cooperate with a placement module for placement in proximity to the treatment area. The apparatus also utilizes a portable main operating unit constructed to fit within a pouch or carrying case worn by the patient. In operation, at least one ultrasonic transducer and at least one electromagnetic coil are activated by transmitting control signals to the placement module from the main operating unit. The activation of the at least one ultrasonic transducer causes ultrasonic waves to be propagated toward the treatment area which are modulated by electrostatic and magnetic forces generated by the at least one electromagnetic coil. The activation of the at least one ultrasonic transducer and the at least one electromagnetic coil may be performed at the same time or at different times for varying periods.

Compositions and methods for the treatment of bone diseases, bone fractures, bone injuries and other bone abnormalities involving the use of Dkk protein, a Wnt antagonist, a Wnt inhibitor, or any other related protein for the stimulation or enhancement of mineralization and for stimulating the renewal of cells. One Dkk protein, Dickkopf-2 (Dkk-2), acts to stimulate bone formation independently of Wnt proteins which may be inhibited and/or antagonized by Dkk-2. Dkk-2 displayed enhanced specific targeting ability and enhanced biological activity in stimulating or enhancing mineralization. Dkk-2 also played a role in the differentiation and self-renewal of hematopoietic stem cells and mesenchymal stem cells, particularly in osteoblastogenesis and osteoclastogenesis.

A Chinese medicine in the form of plaster for treating rheumatic arthritis, hyperosteogeny, cervical spondylopathy, lumbar intervertebral disk protrusion, and muscle and bone injury is prepared from 56 Chinese-medicinal materials including camphor, pinellia tuber, hot pepper, toad venom, etc. Its advantage is high curative effect.

The invention relates to a traditional Chinese medicine preparation for treating fractures and bone injuries. The traditional Chinese medicine preparation is characterized by being prepared from the following raw material medicines: radix notoginseng, draconis sanguis, woodlouse, safflower, peach kernel, eucommia bark, pyrite, teasel root, rhizoma cyperi, mastic, myrrh, white paeony root, rhizoma ligustici wallichii, angelica, earthworm, twotooth achyranthes root, prepared rehmannia root, astragalus root and rhizoma drynariae. The preparation method comprises the following steps: mixing the raw material medicines together, grinding the raw material medicines into a powder shape, sieving the powder into the granularity of 180 meshes, and preparing traditional Chinese medicine medicinal powder. By the clinical test of many years, the invention forms a treating prescription for treating the fractures and the bone injuries by researching the function and indication of each kind of medicine according to modern traditional Chinese medicine pharmacodynamics, carries out the clinical tests on more than one thousand cases of patients with the fractures and the bone injuries and has the effects of promoting blood circulation, relieving the pain, decreasing swelling, eliminating blood stasis, recovering wounds, promoting tissue regeneration, setting bone and treating injuries. The invention can dissipate blood stasis, promote blood circulation, diminish inflammation and alleviate pain, also has the function of tranquilizing the mind and has short treatment course, high curative effect, low treating expense and no adverse reaction and side effect, the cure rate reaches more than 90%, and the curative effect is very satisfactory to people.

The invention belongs to the technical field of medical bone injury restoration materials, in particular discloses anti-collapsibility calcium phosphate cement, as well as a preparation method and the application thereof. The anti-collapsibility calcium phosphate cement is prepared by uniformly mixing 2-10 percent of beta-cyclodextrin or derivates thereof by mass percentage with 90-98 percent of common calcium phosphate cement by mass percentage. The invention successfully applies the beta-cyclodextrin or the derivates thereof to the common calcium phosphate cement for the first time, not only remarkably improves the anti-collapsibility performance of original calcium phosphate cement, but also keeps the original curing characteristics of the original calcium phosphate cement and improves the mechanical performance requirements thereof, effectively improves the success rate of operations, widens the application fields of the beta-cyclodextrin or the derivates thereof and enables the calcium phosphate cement to have wider application prospects.

The invention relates to a cell injection for treating bone injury and a preparation method thereof, belonging to the field of tissue engineering. The injection is a compound formed by mesenchymal stem cells from autologous bone marrow, temperature sensitive gel and effective trophic factors separated and extracted from autoblood. The preparation method comprises the steps of: after extracting the bone marrow of a patient, separating and extracting the mesenchymal stem cells from the bone marrow, adding no animal serum in the amplification culture process, and mixing 1*(105-108) cells with 1-5ml of biological scaffold material to form the injectable compound. The cell injection for treating bone injury is mainly used for treating bone injuries including osteoarthritis, femoral head necrosis and delayed union and disunion of bone fracture, is convenient to use, has notable effect without immunological rejection, and can alleviate the great pain of patients caused by bone injury.

The invention provides a bone filling material of three-dimensional grid structure and a preparation method thereof. The material is characterized in that the material comprises a three-dimensional structure body and alveolate cavities are distributed at all the surfaces of the three-dimensional structure body. The alveolate cavities are in regular grid arrangement and the regular grid is of square array, rectangular array, triangular array, rhombic array or hexagonal array constructed by cylindrical boundaries. The bone filling material is suitable for mixed repair of bone injury.

The invention aims at disclosing a traditional Chinese medicine preparation for treating bone injuries; and consists of blood resin, safflower, woodlouse, earthworm, rhizoma drynariae, olibanum, myrrh, angelica, sapanwood, eucommia bark, pyrite, dipsacus asperoides, red peony root , sweet melon seed and calcined swine mandibular bone which are made into pharmacon with traditional Chinese medicine processing procedure. The invention is used for treating opening fracture, closed fracture, comminuted fracture, greenstick fracture, bone nonunion after operation, hematoma after being hurt and damage of articulatory synovium. The invention has the advantages of having broad spectrum activity, having small toxic and side effect, addressing both the symptoms and root causes, having significant medicine effect, removing clinical symptoms rapidly and having no rebound phenomena after healing.

The invention relates to a biological material for improving release of endothelial progenitor cell exosomes (EPC-EXs) and promoting bone defect repair, and a preparation method and application thereof. The biological material is a polyelectrolyte multilayer film constructed by carrying out in situ intermolecular crosslinking on oxidized chondroitin sulfate (CS) and type I collagen (Col I), wherein the component of the outermost layer is CS; the assembly concentration of each of CS and Col I is 0.5-2mg/mL; the oxidation degree of CS is 25-50%; the assembly conditions are that the pH value is 4.0-5.0 and the ionic strength is 0.15mol/L NaCl; and the temperature is room temperature. The biological material combines the advantages of a material and a cell, and can be widely applied to promotion of vascular regeneration and vascular repair of tissue damages. The angiogenesis is conductive to reducing tissue damages and promoting the repair of damaged bone tissues, so that EPCs and PEC-EXs with the capability of angiogenesis have broad clinical application prospects in bone injury repair.

The invention discloses a preparation method of a composite nano-fiber support material of silk fibroin and calcium silicate. The method comprises the following steps: preparing the silk fibroin; preparing calcium silicate nanometer whiskers; mixing a solvent, the silk fibroin and the calcium silicate nanometer whiskers to obtain spinning solution; and finally carrying out electrostatic spinning and postprocessing to obtain the composite nano-fiber support material. In the invention, composite fiber with a nanometer number grade is prepared based on the electrostatic spinning method so that a nano-fiber complex has good biocompatibility of the silk fibroin and excellent bioactivity of the calcium silicate, is more applicable to the biomedical field, and is expected to become an ideal fiber material for a bone tissue engineering support; and the composite nano-fiber support prepared by the method has higher porosity, good mechanical properties, good air permeability and moisture-penetrability, great liquid absorption quantity and simple preparation method and process, and can be degraded in vivio and promote bone injury tissue repair.

The invention relates to a method of inducing and differentiating human umbilical cord derived mesenchymal stem cells into cartilage cells. The method includes: in order to solve the problem that the prior art is low in differentiation efficiency, cleaning umbilical cord tissue to remove blood stain, cutting the same into small sections, dissecting the small sections to remove vascular tissue, cutting the small sections into pieces, and digesting to obtain a single mesenchymal stem cell; culturing the obtained mesenchymal stem cell in an amplification manner to the seventh generation to obtain a unicellular suspension, inoculating the unicellular suspension into a serum-free culture medium containing a cartilage differentiation inducer to continue culturing, replacing a fresh culture medium every other 3.5 days, and inducing for 14 days to obtain the cartilage cells. The method can efficiently differentiate the umbilical cord mesenchymal stem cells into the cartilage cells and is of important significance in the aspects of restoring cartilage tissue in human bodies and treating bone injury.

The present invention relates to compounds of the formula

or pharmaceutically acceptable salts thereof useful for the prophylaxis and treatment of degenerative bone disorders and for the acceleration of bone healing.

The invention belongs to the field of medical materials for repairing bone injury and related tissues, and particularly discloses rubidium-containing multistage mesoporous bioactive glass, and a preparation method and application thereof. The preparation method comprises the following steps: (1) dissolving a template agent, a calcium source, a phosphorus source and a silicone source in ethyl alcohol to obtain a solution A, and dissolving a rubidium source in deionized water to obtain a solution B; (2) mixing the solution A and the solution B, and stirring for 6 to 12 hours by means of a magnetic stirrer to obtain mixed gel; (3) soaking polyurethane sponge in the mixed gel in the step (3) for 10 to 20 minutes, taking the sponge out, heating and blow-drying the sponge, and repeating the steps for 3 to 6 times; and (4) after the sponge is completely dried, sintering to obtain a rubidium-containing mesoporous bioactive glass medicine carrier. The bioactive glass and the medicine carrier disclosed by the invention have the advantages of high specific surface area, high biocompatibility, high antibacterial property and the like, is applicable to a bone repair material, promotes wound healing of related tissues, and prevents bacterial infection.

The invention provides a bone tissue repair structure based on a shape memory composite material as well as a preparation method and an application method of the bone tissue repair structure. The preparation method comprises the following steps: (1) diagnosing the size and the shape of a bone injury part, so that a three-dimensional figure is obtained; (2) in accordance with the three-dimensional figure, constructing a preset shape of the shape memory composite material during printing by virtue of a computer; (3) uniformly mixing the following components in parts by weight by virtue of an ultrasonic dispersion method: 90-99 parts of a shape memory polymer, 1-5 parts of a reinforcing material and 1-10 parts of magnetic nanoparticles, so as to obtain a thick liquid, curing and cutting the cured liquid so as to obtain a solid in the form of a block; and (4) sequentially conducting extrusion-molding, three-dimensional printing and ultraviolet irradiation cross-linking on the block-shaped solid, so that the bone tissue repair structure of the shape memory composite material in the preset shape is obtained. The bone tissue repair structure disclosed by the invention has the beneficial effects that bone tissue cells can be induced to grow along the recovery direction of the bone tissue repair structure when the bone tissue repair structure is driven by an external magnetic field, so that repair of bone defect is achieved and the bone cells can grow more tightly.

The invention relates to an absorbable orthopedic apparatus material having antibiosis and bone growth promotion functions, and a preparation method thereof. The orthopedic apparatus material is obtained by compounding medical pure magnesium or magnesium alloy with an absorbable high-molecular polymer, the surface of the pure magnesium or magnesium alloy has a porous ceramic layer, the surface of the porous ceramic layer is a functional load layer loaded with bone morphogenetic proteins and copper ions with B-type gelatin as a carrier by adopting an electrophoresis-electrodeposition process, the volume fraction of the pure magnesium or magnesium alloy is 1-99%, the micropore aperture and the thickness of the porous ceramic layer on the surface of the pure magnesium or magnesium alloy are 1-100[mu]m and 1-100[mu]m respectively, and the surface of the porous ceramic layer is the functional load layer loaded with bone morphogenetic proteins and copper ions with B-type gelatin as the carrier by adopting the electrophoresis-electrodeposition process. An orthopedic apparatus can slowly release copper ions having a sterilizing effect and bone morphogenetic proteins having a bone growth promotion effect in the use process, can be applied to restore and fix various bone injuries, and has a wide application prospect.

It is an object of the present invention to provide a method for effectively regenerating bone, and more specifically to provide a method for regenerating bone that is capable of treating patients suffering from bone defect or bone injury. The present invention provides a method for regenerating bone, which comprises culturing and/or transplanting mesenchymal cells in the coexistence of epithelial cells.

The invention relates to a bone scaffold forming system comprising an image scanning unit, a three-dimensional reconstruction unit, a three-dimensional model building unit, a bone scaffold model building unit, a hierarchical processing unit and a low-temperature forming unit. By the aid of the bone scaffold forming system, scanning imaging is performed on the bone injury part of a patient before bone scaffold forming by means of medical imaging technology so as to obtain image data of the bone injury part, then the acquired image data are subjected to modular processing to obtain hierarchical data of a to-be-repaired bone scaffold model, bone formation materials are utilized to prepare a bone scaffold exactly matched with the bone defect part of the patient in size and shape by the low-temperature forming unit through the hierarchical data, and accordingly the bone scaffold matched with the implanting part is prepared for the patient in vitro before surgery implementation to the benefit of shortening implementing time, further implant materials are enabled to be closely bonded with the defect part to promote bone formation.

The invention relates to a traditional Chinese medicine water-bindered pill preparation for treating bone fracture, wherein the composition can be used for treating various traumatic injuries, fractures and soft tissue injuries. The composition consists of traditional Chinese medicines such as peach kernel, pseudo-ginseng, dipsacus root, radix bupleuri, paeonia albiflora, Angelica sinensis, fried rhizoma cyperi, prepared rheum officinale, costus root, dried radix rehmanniae, root of common peony, flowers carthami, ground beeltle, hematoxylon, curcuma zedoary, prepared rheum officinale, herba lycopi, Polygonum cuspidatum, dragon's blood, Hippocampus kuda Bleeker, medical pipefish, prepared frankincense, prepared myrrh, fried rhizoma corydalis, angelica dahurica, dipsacus root, achyranthes root, Eucommia ulmoides, Rhizoma Drynariae, roasted OS macaca, homalomena occulta and lycopodium clavatum, wherein Ligusticum wallichii, prepared frankincense, prepared myrrh and fried rhizoma corydalis can promote qi circulation to relieve pain and remove blood stasis and stimulate the menstrual flow. Peach kernel, pseudo-ginseng, Angelica sinensis, root of common peony, flowers carthami and dragon's blood can stop bleeding and invigorate the circulation of blood and remove stasis and generate new tissues. Dipsacus root, achyranthes root, Eucommia ulmoides, Rhizoma Drynariae, roasted OS macaca, Hippocampus kuda Bleeker, medical pipefish, homalomena occulta and lycopodium clavatum can promote reunion of fractured bones and tonify liver and kidney. Radix bupleuri, radices sileris and the like can dispel wind and relieve exterior syndrome and dredge channels and collaterals. The composition provided by the invention has the bidirectional adjusting effect. The medicines are combined to have the functions of promoting qi circulation to relieve pain, promoting blood circulation to remove blood stasis, tonifying liver and kidney and reuniting bones.

The invention relates to an integrated scaffold for simulating gradient structure from bone-tendon-bone mineralization to non-mineralization, warps are nanofiber yarns with zero mineral content, weftsin the middle of the scaffold are nanofiber yarns with zero mineral content, and wefts from the middle to two ends are nanofiber yarns with gradually increased loaded mineral content. The constructedintegrated scaffold for simulating gradient structure from bone-tendon-bone mineralization to non-mineralization provides an ideal microenvironment for repairing tendon defects, realizes guiding of tendon tissue regeneration after implantation, promotes tendon-bone healing, and is very suitable for tendon-bone injury repairing.

The invention relates to a traditional Chinese medicine, in particular to a plaster for treating bone fracture. The plaster is prepared by stigma croci, Radix Aconiti Kusenzoffii, Pedate PinalliaJackinthepulpit Rhizome, dried pinellia tuber, frankincense, myrrhic, Eupolyphaga, dragon's blood, calcined pyritum, anomalous wormwood, radix dipsaci, hydrargrum oxydatum crudum and sesame oil, adapts to callus growth, cervical spondylosis, lumbar intervertebral disc protrusion, hyperosteogeny, osteoarthritis, rheumatoid arthritis, rheumatoid arthritis and the like, which are caused after traumatic injuries and fracture reduction, and is suitable for treating various bone and joint pains and pains after injury of tendon and muscle.

The invention discloses a traditional Chinese medicine used for treating bone injury, postoperative bone nonunion and delayed union and a preparation method thereof. The invention consists of twenty six traditional Chinese medicines of frankincense, hemlock parsley, cassia twig, myrrh, angelica, rhizoma corydalis, safflower, fossil bone, rhizoma drynariae, elecampane, eucommia bark, dipsacus asperoides, Chinese goldthread, mirabilite, ground beetle, earthworm, DiFeng, Chinese fresh-water crab, oyster, rhubarb, pseudoginseng, borneol, pearl, muskiness, dragon's blood and tiger bone. The invention has good curative effect for the patients with bone injury and fracture nonunion.

The present invention relates to an apparatus for therapeutically treating bone structure using ultrasound, and more particularly, the present invention relates to an apparatus with an attachment structure for treating bone injuries or a variety of musculoskeletal injuries and/or problems.