126 results about "Bone Injury" patented technology

The invention provides a bone fracture rehabilitation dynamic management system and method based on multi-source data analysis. The method comprises the steps that multi-modal physiological data and biomechanical indexes of a target patient in the bone fracture rehabilitation training process are collected; constructing a multi-modal evaluation model based on a space-time convolutional neural network, and inputting the multi-modal physiological data into the multi-modal evaluation model to obtain a multi-modal rehabilitation evaluation score of the target patient; extracting a drift rate of a joint moment center and a chaos characteristic quantity of gait phase deviation in the key biomechanical indexes, performing deviation calibration on endogenous state parameters of the multi-modal evaluation model through the drift rate and the chaos characteristic quantity, and outputting rehabilitation deviation characteristics of a target patient; and generating a digital monitoring report and a personalized adjustment suggestion for bone fracture rehabilitation training of the target patient through the rehabilitation deviation characteristics and the multi-modal rehabilitation evaluation score. Based on the scheme, personalized stage adjustment of digital bone fracture rehabilitation training can be realized.

The invention relates to the technical field of lumbar vertebra traction apparatuses, in particular to a lumbar vertebra traction apparatus for traditional Chinese medicine bone fracture treatment, which comprises a lumbar vertebra traction assembly, a dynamic traction unit and a pyretic moxibustion auxiliary module, in order to solve the problems that in the prior art, common lumbar vertebra traction equipment only conducts static traction on the waist of a patient and is poor in curative effect on chronic lumbar muscle degeneration and other diseases, the static traction function is reserved, meanwhile, the dynamic traction function is achieved, periodic reciprocating traction can be conducted, and the traction effect is good. The device has the advantages of being simple in structure, convenient to use and particularly suitable for patients with bone fractures such as lumbar muscle degeneration, the muscle microcirculation can be improved through rhythmic stretching, the function of well improving lumbar muscle degeneration is achieved, auxiliary pyretic moxibustion can be automatically carried out on the lumbar vertebra position of a patient while traction is carried out, the treatment effect is further improved, an additional power source is not needed, and the device is convenient to use and particularly suitable for being used by the patients with the bone fractures such as the lumbar muscle degeneration.

The invention discloses a bone injury detection method based on ultrasonic guided waves and a multi-branch convolutional neural network, and the method comprises the steps: firstly collecting UGW signals of bone tissues, and carrying out the standardization preprocessing of the UGW signals, so as to eliminate the amplitude difference between different samples; then, data enhancement strategies such as Gaussian noise disturbance and amplitude scaling are adopted, a finite sample set is effectively expanded, and the robustness and generalization ability of the model are improved; a multi-branch convolutional neural network (TB-CNN) structure is constructed, the network designs independent branches for time domain, frequency domain and time-frequency domain input, deep features are automatically extracted from the respective branches, and feature splicing and multi-level information integration are realized in a fusion module; finally, regression prediction of the bone injury depth is realized through a full connection layer, so that continuous value output is obtained, and the severity of the bone injury can be reflected more finely.

The invention discloses a preparation method of a growth factor gradient bionic scaffold for tendon-bone interface regeneration and repair, and belongs to the technical field of biomedical materials. The composite scaffold is constructed by adopting a coaxial electrospinning and self-assembly technology, and is compounded by a core-shell oriented nanofiber layer and a non-oriented nanofiber layer through a gelatin adhesive to respectively simulate tendon phase and bone phase structures of a tendon-bone interface; a shell layer of the tendon-phase-simulated core-shell oriented nanofiber is a PCL layer containing CTGF, a core layer of the tendon-phase-simulated core-shell oriented nanofiber is a PVA layer containing TGF-beta1, and a bone-phase-simulated non-oriented nanofiber layer is a PCL / Gel co-spun layer containing BMP-2 polylactic acid microspheres and nano-hydroxyapatite. The scaffold can realize secondary controlled release of early-stage release of CTGF, slow release of TGF-beta1 in the middle and later periods and continuous release of BMP-2, and cooperates with a fiber orientation structure to induce graded differentiation of mesenchymal stem cells and promote integrated repair of a tendon-bone interface gradient structure, so that the problems of poor healing of a tendon-bone interface and high repeated fracture rate in a traditional repair method are solved, and the scaffold has good application prospects. The important application value is realized in the field of tendon-bone injury treatment in sports medicine.

The invention relates to a degradable piezoelectric nanofiber membrane for bone repair and a preparation method and application thereof.The preparation method comprises the following steps that S1, a PLLA solution and MXene nanosheets are mixed, heated and stirred to obtain a uniform PLLA / MXene mixed solution, and the molecular weight of PLLA in the PLLA solution is 80000-120000; s2, carrying out electrostatic spinning on the PLLA / MXene mixed solution to obtain a PLLA / MXene nanofiber membrane semi-finished product; and S3, carrying out annealing, cooling, heat treatment and secondary cooling on the PLLA / MXene nanofiber membrane semi-finished product to obtain a PLLA / MXene nanofiber membrane finished product, namely the degradable piezoelectric nanofiber membrane. Compared with the prior art, the nanofiber membrane prepared by the method has good biocompatibility, degradability, piezoelectric property and mechanical property, can effectively promote bone tissue regeneration, and provides better material selection for bone injury repair.

The invention relates to an absorbable bone hemostasis and repair stent. The absorbable bone hemostasis and repair stent comprises the following raw materials in parts by weight: 15-60 parts of an excipient, 15-60 parts of a softening agent and 5-70 parts of a bone repair promoting component, the excipient is prepared from a polyoxyethylene-polyoxypropylene copolymer; the softening agent comprises a semi-solid mobile phase polymer; the bone repair promoting component comprises a coating and a core, the coating comprises a polylactic acid-glycolic acid copolymer, zinc stearate and potassium bromide, the core comprises calcium phosphate particles, and the coating wraps the surface of the core. The preparation method comprises the following steps: preparing the bone repair promoting component; and preparing the absorbable bone hemostasis repair stent. The absorbable bone hemostasis and repair stent is high in hemostasis and collapse resistance and has good inflammation regulation and bone repair promoting effects. The absorbable bone hemostasis and repair stent can be used for bone hemostasis and bone repair promotion of any bone injury wound.

The present application relates to a kind of self-setting composite bone implants based on gallic acid complex salt and preparation method thereof, belong to bone repair material field.The present application is specifically related to a kind of self-setting composite bone implants, it is characterized in that, component A, component B and component C, the component A is gallic acid and the complex salt of at least two metal elements, wherein the at least two metal elements are the metal element of promoting bone tissue regeneration or the trace metal element required by human body, and the at least two metal elements include calcium, the component B is the complex of calcium / strontium chondroitin sulfate and calcium sulfate, and the component C is magnesium calcium hydrogen phosphate complex.The self-setting composite bone implant of the present application has the characteristics of antibacterial, anti-inflammatory, promoting osteogenesis, instant shaping and all degradation, can meet the clinical needs of bone tumor, bone injury and the like, has wide application prospect in various bone repair, reconstruction and replacement.

The utility model relates to a physical therapy device, in particular to a moxa steaming physical therapy device for bone fracture. The moxa steaming physical therapy device for bone fracture comprises a base, a physical therapy bed, a physical therapy cover, curtain cloth, a pillow, a medicine fumigation plate, a partition plate, a sealing ring, a steam water tank, a steam guide pipe, a steam adjusting valve and the like. A physiotherapy couch is arranged at the top of the base, a physiotherapy cover and a pillow are arranged at the top of the physiotherapy couch, a rectangular hole and sliding grooves are formed in the physiotherapy couch, the sliding grooves are located in the two sides of the rectangular hole, a medicine fumigating plate is arranged in the physiotherapy couch in a sliding mode, a plurality of round holes are formed in the medicine fumigating plate, three through holes are formed in the middle of the top of the physiotherapy couch, and a partition plate is connected between the medicine fumigating plate and the physiotherapy couch. Due to the design of the steam regulating valve and the partition plate, local fumigation of a patient is achieved, unnecessary waste of herbs is reduced, and treatment cost is reduced.

The utility model discloses an adjustable bone fracture splint, and relates to the technical field of medical apparatus and instruments, the adjustable bone fracture splint comprises: a movable fixing frame; the lifting mechanism is mounted on the fixing frame; the fixing part of the clamping plate mechanism is connected with the lifting part of the lifting mechanism so that the clamping plate mechanism can move up and down along with the lifting part, and the clamping plate mechanism further comprises a first clamping plate capable of moving relative to the fixing part and a second clamping plate fixed to the fixing part. The operation method is simple, and the height and the direction can be adjusted, so that the range of users is wider.

The utility model relates to medical auxiliary instrument technical field provides a kind of bone injury patient implant screw's taking-out device, including ring main body, internal fixation assembly and external fixation assembly.The internal fixation assembly includes expansion cylinder and expansion column, the expansion cylinder is set along the inner ring side of ring main body Circumferentially, expansion column can pass through the inner ring of ring main body, and expansion cylinder is expanded tightly.One end of expansion column located outside expansion cylinder is equipped with a rotating head.The external fixation assembly includes tightening cylinder and hoop ring, tightening cylinder is circumferentially arranged at the outer edge of ring main body, hoop ring can be sleeved on tightening cylinder, and tightening cylinder can be tightened.The bone injury patient implant screw's taking-out device proposed in the utility model can greatly improve the friction between it and implant screw, in the process of taking out implant screw, it can effectively avoid the problem of skidding, especially suitable for the case that the internal hexagonal groove of implant screw is rounded, and it is difficult to take out.

The invention provides a muscle-bone injury area identification method and system, and relates to the technical field of muscle-bone image injury identification. The method comprises the following steps: acquiring a two-dimensional gray-scale ultrasonic image of a target muscle-bone injury area, and positioning a synovial tissue area from the two-dimensional gray-scale ultrasonic image; extracting target feature information from the synovial tissue region; and determining the inflammation activity degree of the synovial tissue according to the target feature information. According to the method, Doppler blood flow signals are completely bypassed, the rheumatism inflammation activity degree is evaluated only through rich information contained in the two-dimensional gray-scale ultrasonic image, and therefore interference of probe pressure artifacts is thoroughly avoided.

This utility model discloses a forearm splint for bone injury care, comprising a cut-resistant braided layer, a covering strap fixedly installed on the inner side of the cut-resistant braided layer, a tension adjustment slit on the surface of the cut-resistant braided layer and the covering strap, and closing straps installed on both sides of the tension adjustment slit. Multiple axial support components are installed on the inner side of the covering strap. An elbow locking component and a wrist locking component are respectively installed between the upper and lower ends of the cut-resistant braided layer and the covering strap. Both the elbow locking component and the wrist locking component include a tension adjustment box, and a locking knob is installed in the middle of the tension adjustment box. The elbow locking component also includes a first connecting wire slidably connected to one of the tension adjustment boxes. This utility model, by adjusting the locking at both ends of the forearm, satisfies the applicability and fit of forearms of different sizes, improves the uniform clamping of the forearm, and facilitates the examination of the forearm skin.

The utility model relates to medical equipment technical field discloses a traditional chinese medical science bone injury fomentation device, including the carrier plate and fixed block one and fixed block two, the right side rotation of carrier plate is connected with one of elastic band, the inside of fixed block one is equipped with the slow groove, the inside slide of slow groove is connected with two sliding blocks one, the similar side fixed connection of two sliding blocks one has spring no.

The invention discloses an application of a JAM3 modified engineered vesicle in preparation of a medicine for treating bone injury, the JAM3 modified engineered vesicle is prepared, and the osteogenesis promoting effect of the JAM3 modified engineered vesicle on bone marrow mesenchymal stem cells (BMSCs) is proved through ALP staining, RT-qPCR, WB and other experiments at the cellular level, so that the osteogenesis promoting effect of the JAM3 modified engineered vesicle on the bone marrow mesenchymal stem cells (BMSCs) is improved, and the osteogenesis promoting effect of the JAM3 modified engineered vesicle on the bone marrow mesenchymal stem cells (BMSCs) is improved. Meanwhile, the effect of JAM3 modified engineered vesicles on promoting osteogenesis of bone defect mice is defined through in-vivo experiments. According to the invention, osteogenesis direction differentiation and bone formation capability of BMSC can be promoted, and bone formation capability of bone defect mice can be promoted in vivo; the compound can be used for treating related diseases such as bone injury.

The application discloses a traditional Chinese medicine for treating contusion and injury, postoperative swelling and pain, and early swelling and pain of broken tendon and bone injury, which is configured from angelica sinensis, ligusticum chuanxiong, red peony root, prepared rehmannia, persicae semen, safflower, costus, fructus aurantii, panax notoginseng, poria cocos, alisma orientalis, astragalus membranaceus and rhizoma corydalis. The medicine is prepared according to the traditional Chinese medicine dialectical theory, has the effects of activating blood and resolving stasis, eliminating swelling and relieving pain, has reasonable formula, simple manufacturing process, remarkable curative effect, convenient use and moderate price, and is an effective prescription for treating tendon and bone pain in traditional Chinese medicine.

The invention discloses qi-tonifying and bone-strengthening pills and a preparation method thereof, and belongs to the technical field of bone fracture pills. The qi-tonifying and bone-strengthening pill is prepared from the following raw materials: semen cuscutae, herba epimedii, cynomorium songaricum, salted radix dipsaci, scalded rhizoma drynariae, radix polygoni multiflori preparata, radix rehmanniae preparata, fructus lycii, wine-processed glossy privet fruit, herba ecliptae, raspberry, deer-horn glue, tortoise-shell glue, radix astragali preparata, radix angelicae sinensis, radix salviae miltiorrhizae, rhizoma dioscoreae, pericarpium citri reticulatae, fried semen ziziphi spinosae and radix glycyrrhizae preparata. The preparation method of the qi-tonifying and bone-strengthening pill comprises the following steps: adding water into the scalded rhizoma drynariae, and decocting; respectively crushing semen cuscutae, fried spina date seeds and dried orange peel; decocting the raw materials except deer-horn glue and tortoise-shell glue with the crushed semen cuscutae and fried spina date seeds in water, and concentrating the filtrate; and melting deer-horn glue and tortoise-shell glue in the concentrated liquid medicine, adding the crushed dried orange peel and a proper amount of refined honey, uniformly stirring, pelleting and drying to obtain the medicine. The qi-tonifying and bone-strengthening pill is mainly used for treating liver and kidney deficiency type arthralgia, poor rehabilitation in the later period of fracture and other symptoms, and has the functions of tonifying kidney and qi, and strengthening bones and promoting reunion of tendons.

The invention discloses a preparation method of a traditional Chinese medicine external formula with a bone fracture rehabilitation effect. The preparation method comprises the following steps: step 1, preparing a traditional Chinese medicine extract; the preparation method comprises the following steps: 1, weighing the following raw material medicines in proportion: radix clematidis, cortex mori radicis, flos carthami, radix stephaniae tetrandrae, herba lycopodii, fructus liquidambaris, radix gentianae macrophyllae, radix saposhnikoviae, radix angelicae sinensis, radix angelicae dahuricae, fructus chaenomelis, vinegar-processed rhizoma corydalis, poria peel, processed frankincense and processed myrrh; 2, the raw material medicines are smashed and then mixed or the raw material medicines are mixed and then smashed, and a mixture is obtained.On the basis of the PCT concept, in-vitro shock wave treatment and an external formula are applied to treatment of a patient suffering from plantar fasciitis, compared with single in-vitro shock wave treatment, the inflammatory factor level can be better reduced through combination of the in-vitro shock wave treatment and the external formula, and the curative effect is better. Meanwhile, the production method of the external use formula disclosed by the invention is few in steps and simple to operate.

The invention provides an intelligent getting-up and moving auxiliary device for a bone fracture patient, and belongs to medical auxiliary equipment. The device comprises a movable seat, a back cushion, a connecting handle, a fixing plate and the like, the movable seat is connected with an electric control movable wheel through an upper connecting frame and a lower connecting frame, the connecting handle is arranged at the wheel shaft end to assist steering, the upper connecting frame is provided with a pasting ring belt and a sleeve to fix the body, the back cushion provides back support, the connecting handle assists the body to get up and sit up, and the fixing plate enhances the structural strength. The position of a connected concave connecting plate can be adjusted, a front moving wheel and an aluminum alloy pedal are arranged at the bottom of a lower connecting frame, a storage net is arranged at the rear end of a seat, and a pulling handle is arranged on the outer surface of the seat. And favorable conditions are created for rehabilitation of patients.

An electroactive titanium support-reinforced composite film includes a titanium support and a film material coating the titanium support. The titanium support has a structure designed according to securing sites. The electroactive titanium support-reinforced composite film of the present invention can be bent and shaped for a close fit with a hard tissue, has excellent mechanical performance and a stable electroactive bending strength of bionic magnitude, and can prevent the collapse of surrounding tissues and tissue adhesion, effectively maintain a three-dimensional space for bone osteanagenesis and effectively promote bone injury healing, featuring ease and convenience of clinical operation and capability of promoting bone marrow mesenchymal stem cell adhesion, cytoskeleton rearrangement and induced osteogenic differentiation. The support-reinforced composite film is suitable for mandible or cranium injury repair in different ranges and has significant efficacy for clinical indications such as alveolar bone vertical bone augmentation and alveolar ridge preservation after tooth extraction.

The invention belongs to the field of medical technical instruments, and particularly discloses a fixing device for a small arm bone fracture callus formation period, which comprises an upper arm fixing and limb length adjusting assembly, a small arm angle adjusting assembly and a small arm clamping assembly, the upper arm fixing ring is an elastic arc-shaped plate and is fixed through a hook-and-loop fastener bandage, the outer side of the upper arm fixing ring is connected with the upper arm supporting frame, and a sliding adjusting structure of the upper arm supporting frame and the upper arm support can adapt to the limb lengths of different patients. A shaft seat at the bottom of the upper arm support is matched with a rotating shaft to adjust the angle of the forearm support, a lead screw transmission structure in the forearm supporting frame drives an arc-shaped clamping plate to clamp the forearm to fix, the clamping plate is provided with an air hole, a rubber gasket and a fixing ring are arranged on the supporting frame, a buffering pad is arranged on the inner side of the clamping plate, and the forearm supporting frame is connected with a shoulder strap through a buckle. According to the device, practicability and comfort are both considered, all assemblies can be adjusted, the forearm can be accurately fixed, the requirements of different patients are met, the comfort is improved, the complication risk is reduced, the structure is compact, and operation is convenient and fast.

The invention discloses a pharmaceutical composition for bone diseases and bone fractures. The pharmaceutical composition is prepared from the following raw material medicines in parts by weight: 15-25 parts of calcined native copper, 10-20 parts of vinegar myrrh, 10-20 parts of vinegar frankincense, 3-10 parts of cornu cervi degelatinatum, 3-10 parts of white dipsacus, 3-10 parts of safflower carthamus, 15-25 parts of ground beetles, 3-10 parts of white mulberry root-bark and 3-10 parts of dragon's blood. The fine powder of the pharmaceutical composition and pharmaceutically acceptable auxiliary materials or auxiliary components are prepared into an external preparation. The patch has good biocompatibility with skin, and the hydrophilic polymer matrix has air permeability, perspiration resistance, no sensitization and no irritation; the drug release performance is good, the affinity with the skin is strong, the hydration effect of the cuticle can be improved, and the transdermal absorption of the drug is facilitated; a transdermal absorption controlled release technology is applied, so that the blood concentration is stable, and the drug effect is lasting.

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for early and middle stages of bone fracture, a preparation method and application. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 25 to 75 parts of radix salviae miltiorrhizae, 12 to 38 parts of flos carthami, 8 to 25 parts of dragon's blood, 10 to 30 parts of radix paeoniae rubra, 25 to 75 parts of radix angelicae pubescentis, 15 to 45 parts of rhizoma corydalis, 12 to 38 parts of rhizoma seu radix notopterygii, 12 to 38 parts of radix angelicae, 10 to 30 parts of rhizoma arisaematis, 25 to 75 parts of rhizoma sparganii, 12 to 38 parts of rhizoma curcumae, 10 to 30 parts of pericarpium citri reticulatae viride, 10 to 30 parts of pericarpium citri reticulatae, 10 to 30 parts of radix aucklandiae, 25 to 75 parts of polyporus umbellatus, 15 to 45 parts of fructus liquidambaris, 12 to 38 parts of cortex phellodendri, 12 to 38 parts of rhizoma atractylodis, the traditional Chinese medicine is prepared from 12-38 parts of radix trichosanthis, 25-75 parts of fructus kochiae, 15-45 parts of fructus cnidii, 12-38 parts of radix dipsaci, 12-38 parts of rhizoma drynariae and 5-20 parts of radix glycyrrhizae. The traditional Chinese medicine composition can promote blood circulation, stop bleeding, relieve swelling and pain, remove blood stasis, promote the circulation of qi, clear away heat, remove dampness and reunion fractures and tendons in the new injury period, and meanwhile is resistant to allergy and high in safety.

The invention discloses an ointment smearing device for the orthopedics department, and relates to the technical field of ointment smearing devices, the ointment smearing device comprises a storage cavity, a T-shaped plate and a handle plate, a medicine inlet is formed in one side of the outer wall of the storage cavity, and a feeding door is arranged on the inner surface wall of the medicine inlet. According to the scheme, after bone and traumatology plaster is stored in the storage cavity, six heating pipes are started through a controller, under the action of a heat preservation sleeve and a temperature sensor, the interior of the plaster conveying pipe can be heated to the needed temperature, then an electric telescopic rod is started through the controller, and under the action of two limiting rods and a limiting ring, the plaster conveying pipe can be heated to the needed temperature; when the bone fracture plaster is applied, the extrusion medicine feeding plate can be driven to move downwards, the bone fracture plaster in the storage cavity enters the plaster conveying pipe along the round medicine outlet hole, at the moment, the internal orthopedic plaster is preheated, finally, the bone fracture is applied along the strip-shaped medicine outlet hole and the applying nozzle, and it can be guaranteed that the orthopedic plaster cannot be cooled; the ointment can be absorbed by the wounded part in time, and the treatment effect is improved.

The invention provides an application of lurasidone or a pharmaceutically acceptable salt thereof in preparation of a medicine for preventing and / or treating diabetes individual bone injury healing disorder. The hyperglycemia environment causes excessive secretion of lipocalin-2 (LCN2) by activating a phosphopentose pathway of neutrophil, thereby inhibiting osteogenic differentiation of skeletal stem cells. According to the application of the lurasidone or the pharmaceutically acceptable salt thereof in the preparation of the medicine for preventing and / or treating the diabetic individual bone injury healing disorder, in the application provided by the invention, the lurasidone can specifically inhibit the metabolic pathway and the secretion of LCN2, remodel an immune microenvironment beneficial to repair, and promote the healing of the diabetic individual bone injury. The formation of callus under the condition of diabetes mellitus is obviously accelerated and the mineral density of bone is improved.

The invention discloses a bone fracture rehabilitation treatment device, and relates to the technical field of bone fracture rehabilitation assistion.The bone fracture rehabilitation treatment device comprises a leg support, a supporting frame is movably arranged at the bottom end of the leg support, a rotating shaft is fixedly arranged at one end of the leg support, a rotating adjusting assembly is arranged in a bending frame, and the rotating adjusting assembly comprises an adjusting part and a torsion part; the torsion part is matched with the rotating shaft, the adjusting part controls connection of the torsion part and the rotating shaft, a fumigation assembly is arranged on the outer side of the fumigation pinch plate, and the device achieves'load / no-load 'switchable design of shank lifting training through ingenious matching of the rotating adjusting assembly and the torsion part. Through free rotation of the bending frame around the rotating shaft, low-intensity movement is performed on muscles around the shank, the situation that a bone fracture part is injured due to overlarge load is avoided, muscle strength is intensified in a targeted mode, blood circulation is promoted, a good muscle supporting and metabolism environment is provided for bone fracture healing, and the progressive scientific rehabilitation rhythm is achieved.

The invention discloses a space-time responsive multifunctional 3D printing bone repair scaffold as well as a preparation method and application thereof. PDGF-BB is loaded on a quick-release carrier, MgP is loaded on a slow-release carrier, and the multifunctional 3D printing bone repair scaffold with MgP loaded on the inner layer and PDGF-BB loaded on the outer layer is prepared through 3D printing. Wherein the PDGF-BB is used as an immunomodulator, the MgP is used as a regeneration inducer, and after the carrier is implanted into a body, according to different carrier degradation rates, the PDGF-BB is degraded and released in a space-time responsive manner to realize early immunoregulation and endothelial cell recruitment, and then magnesium ions and phosphate ions are degraded and released to synergistically promote vascularization and osteogenesis in middle and later periods with the PDGF-BB. In-vitro and in-vivo experiments prove that the 3D printing bone repair scaffold provided by the invention has immunoregulation, angiogenesis promotion and osteogenesis properties, can be used for repairing inflammatory bone injury, and is particularly suitable for repairing inflammatory bone injury caused by diabetes.

This invention discloses a nanoparticle targeting bone tissue macrophages, its preparation method, and its applications, belonging to the field of biomedical technology. This invention employs a dual targeting mechanism, modifying the nanoparticle surface with bone-like peptide sequences and mannose-modified ligands, enabling the nanoparticles to specifically recognize macrophages in the bone tissue environment. The bone tissue macrophage-targeting nanoparticle system prepared by this invention can significantly improve targeting efficiency, anti-inflammatory effects, and tissue repair effects, while reducing systemic side effects, providing a new treatment approach for bone injury repair and showing promising clinical application prospects.

The invention discloses a pharmaceutical composition for bone fracture and a preparation and a preparation method thereof. The pharmaceutical composition is prepared from, by weight, 2-6 parts of calcined native copper, 0.5-1.5 parts of himalayan teasel root pieces, 6-8 parts of dried ginger, 0.5-1.5 parts of ground beetles, 1.5-2.5 parts of prepared kusnezoff monkshood roots, 1.5-2.5 parts of large-leaved gentian, 30-40 parts of vinegar frankincense, 30-40 parts of vinegar myrrh, 0.5-1.5 parts of muskmelon seeds, 1.5-2.5 parts of pseudo-ginseng, 0.5-1.5 parts of prepared nux vomica, 0.5-1.5 parts of dragon's blood, 0.5-1.5 parts of safflower and 0.5-1.5 parts of radix stephaniae tetrandrae. , 0.5 to 1.5 parts of Chinese angelica, 1.5 to 2.5 parts of radix aconiti preparata, and 0.5 to 1.5 parts of cassia twig. And a transdermal absorption plaster preparation is prepared. The pharmaceutical composition and the preparation thereof have the functions and functions of mainly treating bone reunion and swelling and pain relief, and are used for various types of closed fractures. A plurality of traditional Chinese medicine components are reasonably proportioned, the preparation method is unique, the auxiliary materials are well proportioned, the forming effect is good, the patch can be directly pasted on the affected part, the main medicine is uniformly dispersed in the matrix through transdermal absorption, the medicine directly reaches the affected part, the medicine effect is directly exerted, the effect is strong, the curative effect is remarkable, the use is convenient, and the medication is safe.

The invention discloses a traditional Chinese medicine composition for bone fracture and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine formulas and preparation thereof, and the traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: angelica sinensis, liquorice, dipsacus root, rheum officinale, frankincense, pawpaw, ground beetle, fructus psoraleae, achyranthes bidentata and borax. The preparation method comprises the following steps: weighing all the medicinal materials according to the proportion, classifying, and respectively carrying out impurity removal and cleaning treatment; performing drying; crushing the special medicinal materials one by one; hard and large medicinal materials are pre-crushed; uniformly mixing the pre-crushed medicinal materials with the residual uncrushed medicinal materials, and performing fine crushing; uniformly mixing the powder obtained by fine crushing with the powder of the special medicinal materials; and screening to obtain the powdery medicinal material with the required granularity. The traditional Chinese medicine composition provided by the invention has a relatively good treatment effect, and the provided preparation method can keep active ingredients in the medicinal materials and improve the medicine effect; the loss of effective components is reduced; the preparation process is easy to control and the product quality is stable.

The present application relates to a kind of absorbable bone hemostasis repair bracket, the absorbable bone hemostasis repair bracket includes the following weight parts of raw materials: excipient 15~60 parts, softening agent 15~60 parts and promote bone repair component 5~70 parts;The excipient includes polyoxyethylene-polyoxypropylene copolymer;The softening agent includes semi-solid mobile phase polymer;The promote bone repair component includes coating and core, the coating includes polylactic acid-glycolic acid copolymer, zinc stearate and potassium bromide, the core includes calcium phosphate salt particle, and the coating is wrapped in the surface of core.The preparation method includes the following steps: the preparation of promote bone repair component;The preparation of absorbable bone hemostasis repair bracket.The present application absorbable bone hemostasis repair bracket hemostasis anti-ability of scattering is strong, and has good inflammation regulation and promote bone repair effect.The present application absorbable bone hemostasis repair bracket can be used for any bone injury wound surface bone hemostasis and promote bone repair.