Plaster for treating bone fracture and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine, and discloses a plaster for treating bone fracture and a preparation method thereof, and the plaster comprises the following raw materials: peach kernel, safflower, ligusticum wallichii, radix cyathulae, rhizoma drynariae, radix angelicae pubescentis, notopterygium root, eucommia ulmoides, astragalus membranaceus, pseudo-ginseng, native copper, dragon's blood, catechu, angelica sinensis, radix rehmanniae, gentiana macrophylla, radix saposhnikoviae, earthworm, centipede, scorpion, ground beetle, liquorice, frankincense, myrrh, yellow lead, sesame oil and other auxiliary materials. Pseudo-ginseng is added into the formula, the effects of promoting blood circulation to remove blood stasis, diminishing swelling and relieving pain of pseudo-ginseng are utilized, absorption of blood stasis of the bone fracture part can be accelerated, then pain and swelling caused by blood stasis blocking are remarkably relieved, blood circulation is promoted, and injury repair is promoted, and radix angelicae sinensis and radix rehmanniae are added into the formula, and the effects of replenishing blood and promoting blood circulation of radix angelicae sinensis and nourishing yin and cooling blood of radix rehmanniae are utilized, so that the bone fracture can be cured, and the bone fracture can be cured. And blood generation and local microcirculation improvement can be promoted, so that the blood supply and oxygen supply capacity of a bone fracture repair part is enhanced, and soft tissue repair is accelerated.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a plaster for treating bone injuries and a preparation method thereof. Background Art

[0002] Bone injury refers to the general term for injuries to bones, joints and their surrounding tissues (including muscles, fascia, ligaments, etc.) caused by external forces, strain, diseases, etc., mainly manifested as fractures, soft tissue contusions, joint injuries and rheumatic bone diseases. The treatment goals of bone injuries are to relieve pain, promote blood stasis absorption, improve microcirculation, and accelerate the repair of bones and soft tissues. Traditional Chinese medicine has a long history and unique advantages in the treatment of bone injuries. Among them, plasters are widely used in the treatment of bone injuries because of their local application, direct efficacy to the lesion, and ease of use.

[0003] The plaster products currently on the market have achieved certain results in the treatment of bone injuries, but they still have the following shortcomings: Single efficacy: Many plasters only focus on a single efficacy, such as promoting blood circulation and removing blood stasis or replenishing qi and blood, but fail to fully cover the multiple effects required in the treatment of bone injuries.

[0004] Imperfect combination of ingredients: The combination of some plasters fails to take into account the needs of promoting blood circulation, reducing swelling, replenishing blood, and setting bones, resulting in limited therapeutic effects, especially in fracture healing and soft tissue repair.

[0005] Long treatment period: Some plasters are slow to take effect when treating bone injuries and cannot quickly relieve pain or blood stasis, thus prolonging the patient's recovery period.

[0006] Limited scope of patient application: The ingredients and effects of many plasters are too targeted and are not suitable for patients with complex bone injuries or those with multiple diseases. Summary of the invention

[0007] In view of the deficiencies in the prior art, the present invention provides a plaster for treating bone injuries and a preparation method thereof, which solves the problems in the prior art that the plaster products currently on the market have a single therapeutic effect, imperfect ingredient combination, a long treatment cycle and a limited scope of patient application.

[0008] To achieve the above purpose, the present invention is implemented by the following technical scheme: a plaster for treating bone injuries, comprising the following raw materials: Peach kernel, safflower, chuanxiong, chuanxiong, drynaria, angelica, angelica dahurica, angelica notoginseng, natural copper, blood clotting, catechu, angelica sinensis, radix rehmanniae, gentiana macrophylla, siler, earthworm, centipede, whole worm, earthworm, liquorice, frankincense, myrrh, yellow ochre, sesame oil and other auxiliary materials.

[0009] Preferably, the raw materials include, by mass: Peach kernel 55-65g, safflower 45-55g, Chuanxiong 45-55g, Chuanxiong 55-65g, Drynaria 55-65g, Duhuo 115-125g, Qianghuo 115-125g, Eucommia 50-60g, Astragalus 45-55g, Panax notoginseng 90-100g, Natural copper 50-60g, Sanguisorba officinalis 35-45g , catechu 35-45g, angelica 90-100g, raw rehmannia 90-100g, qinjiao 95-105g, siler 95-105g, earthworm 55-65g, centipede 15-25g, whole insect 25-35g, earthworm 40-50g, licorice 55-65g, frankincense 55-65g, myrrh 55-65g, yellow lead 3700-3800g, sesame oil 7400-7600g, other auxiliary materials 750-850g.

[0010] Preferably, the specific quality of the raw materials is: 60g peach kernel, 50g safflower, 50g chuanxiong, 60g chuanxiong, 60g drynaria, 120g angelica, 120g angelica dahurica, 60g eucommia, 50g astragalus, 100g panax notoginseng, 60g natural copper, 40g blood clotting, 40g catechu, 100g angelica, 100g raw rehmannia, 100g qinjiao, 100g siler, 60g earthworm, 20g centipede, 30g whole insect, 50g earthworm, 60g licorice, 60g frankincense, 60g myrrh, 3750g yellow lead, 7500g sesame oil, and 800g other auxiliary materials.

[0011] Preferably, the other auxiliary materials include one or more of excipients or stabilizers, and the excipients and stabilizers are beeswax and rosin, which are used to adjust the viscosity and hardness of the plaster, with a total weight of 800g.

[0012] A method for preparing a plaster for treating bone injuries comprises the following steps: (a) Formula preparation: weigh peach kernel, safflower, Chuanxiong, Chuanxiong, Drynaria, Angelica dahurica, Notopterygium wilfordii, Eucommia ulmoides, Astragalus, Panax notoginseng, natural copper, Sanguisorba officinalis, catechu, Angelica sinensis, Radix Rehmanniae, Gentiana macrophylla, Saposhnikovia divaricata, earthworm, centipede, whole worm, earthworm, liquorice, frankincense, myrrh, yellow lead, sesame oil and other auxiliary materials; (b) Soaking medicinal materials: Soak sesame oil, peach kernel, safflower, Chuanxiong, Chuanxiong, Drynaria, Angelica dahurica, Notopterygium wilfordii, Eucommia bark, natural copper and liquorice in an iron pot for 7 to 8 days to release fat-soluble components; (c) Heating and cooking Heat the soaked herbs and sesame oil over low heat, stirring and controlling the temperature; Then add astragalus, notoginseng, angelica, raw rehmannia, gentiana macrophylla, saposhnikovia, earthworm, centipede, whole insect, earthworm, dragon's blood, catechu, frankincense, myrrh and other auxiliary materials in turn, and continue to boil and stir until the medicinal materials are fried yellow but not carbonized; (d) Filtration and clarification: remove the drug residue and filter out the oil; (e) Concentrating and boiling the oil: until the smoke produced by the liquid medicine changes from green smoke and black smoke to white smoke, then gradually add yellow lead, stirring while adding, and check the temperature by dripping water to ensure that the ointment is suitable and the ointment is of appropriate hardness and softness, which is easy to shape and has stable efficacy; (f) Cooling and detoxification: After cooling the ointment, soak it in cold water for 7 days to remove the fire poison; (g) Spreading plaster: forming into plaster sheets suitable for different parts of the body.

[0013] Preferably, the optimal temperature for detecting the heat by the water dripping method is controlled between 230°C and 280°C to ensure the full fusion of yellow lead and the medicinal solution and avoid carbonization of the medicinal material.

[0014] Preferably, a wet willow stick or a wet locust tree stick is used in steps (c) and (e), and stirring is continued in the same direction.

[0015] Preferably, in step (e), when the water drops form beads and do not disperse, it indicates that the consistency of the medicinal solution is appropriate, the yellow lead and the medicinal solution are fully integrated, and the viscosity and efficacy of the finished plaster are both in an appropriate state.

[0016] The present invention provides a plaster for treating bone injuries and a preparation method thereof. The plaster has the following beneficial effects: 1. The present invention adds Panax notoginseng to the formula and utilizes its effects of promoting blood circulation, removing blood stasis, relieving swelling and relieving pain, thereby accelerating the absorption of blood stasis in the bone injury area, thereby significantly alleviating the pain and swelling caused by blood stasis blockage, and promoting blood circulation and injury repair.

[0017] 2. The present invention adds angelica and raw rehmannia to the formula, utilizing the blood-tonifying and blood-activating effects of angelica and the yin-nourishing and blood-cooling effects of raw rehmannia, thereby promoting blood production and improving local microcirculation, thereby enhancing the blood and oxygen supply capacity of the bone injury repair site and accelerating soft tissue repair.

[0018] 3. The present invention adds eucommia bark and natural copper into the formula, utilizes the liver and kidney nourishing and bone and tendon strengthening functions of eucommia bark and the bone and tendon repairing function of natural copper, can stimulate the activity of osteoblasts, thereby accelerating fracture healing and callus formation, improving bone density and enhancing bone strength.

[0019] 4. The present invention adds earthworms to the formula and utilizes its properties of breaking blood, removing blood stasis, repairing tendons and bones to quickly reduce swelling and inflammatory reactions at the site of bone injury, thereby promoting blood stasis absorption and tissue cell regeneration, and accelerating the soft tissue repair process. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 It is a flow chart of the preparation method of the present invention. DETAILED DESCRIPTION

[0021] The following will be combined with the drawings in the specification of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0022] In order to better understand the present invention, the above contents are described in detail below in conjunction with specific embodiments. Please see attached Figure 1 The embodiment of the present invention provides a plaster for treating bone injuries, comprising the following raw materials: peach kernel, safflower, chuanxiong, chuanxiong, drynaria, angelica dahurica, notopterygium, eucommia, astragalus, panax notoginseng, natural copper, blood clotting, catechu, angelica, radix rehmanniae, gentiana macrophylla, siler, earthworm, centipede, whole insect, earthworm, licorice, frankincense, myrrh, yellow ochre, sesame oil and other auxiliary materials.

[0023] Raw materials, by mass, include: Peach kernel 55-65g, safflower 45-55g, Chuanxiong 45-55g, Chuanxiong 55-65g, Drynaria 55-65g, Duhuo 115-125g, Qianghuo 115-125g, Eucommia 50-60g, Astragalus 45-55g, Panax notoginseng 90-100g, Natural copper 50-60g, Sanguisorba officinalis 35-45g , catechu 35-45g, angelica 90-100g, raw rehmannia 90-100g, qinjiao 95-105g, siler 95-105g, earthworm 55-65g, centipede 15-25g, whole insect 25-35g, earthworm 40-50g, licorice 55-65g, frankincense 55-65g, myrrh 55-65g, yellow lead 3700-3800g, sesame oil 7400-7600g, other auxiliary materials 750-850g.

[0024] The specific quality of the raw materials is: 60g peach kernel, 50g safflower, 50g chuanxiong, 60g chuanxiong, 60g drynaria, 120g angelica, 120g angelica dahurica, 60g eucommia, 50g astragalus, 100g panax notoginseng, 60g natural copper, 40g blood clotting, 40g catechu, 100g angelica, 100g raw rehmannia, 100g qinjiao, 100g siler, 60g earthworm, 20g centipede, 30g whole insect, 50g earthworm, 60g licorice, 60g frankincense, 60g myrrh, 3750g yellow lead, 7500g sesame oil, and 800g other auxiliary materials.

[0025] Other auxiliary materials include one or more of excipients or stabilizers. The excipients and stabilizers are beeswax and rosin, which are used to adjust the viscosity and hardness of the plaster. The total weight is 800g.

[0026] in: Peach kernel: bitter, sweet, and flat in nature, it can promote blood circulation and remove blood stasis, moisten the intestines and promote bowel movements. It can also promote blood circulation and remove blood stasis, and is used to treat pain and swelling caused by blood stasis. The moisturizing effect indirectly promotes metabolism in the body and is beneficial to bone injury recovery. Safflower: Medicinal properties: pungent, warm, can promote blood circulation and menstruation, dissipate blood stasis and relieve pain. Used for pain caused by trauma and blood stasis; Safflower with peach kernel has a stronger effect of promoting blood circulation and removing blood stasis, which helps to accelerate the absorption of blood stasis.

[0027] Chuanxiong: Medicinal properties: pungent, warm, can promote blood circulation and qi, dispel wind and relieve pain. Promote blood circulation, relieve pain caused by blood stasis; can also improve qi and blood blockage at the fracture site.

[0028] Chuanxi: Medicinal properties: pungent, warm, can dispel rheumatism, promote blood circulation and relieve pain. Used for limb pain caused by rheumatism, the rheumatism dispelling effect can relieve inflammation and stiffness in the injured bone.

[0029] Drynaria fortunei: Medicinal properties: bitter, warm. It can nourish the kidney and strengthen bones, repair tendons and bones. It accelerates fracture healing, enhances bone strength, and has a significant effect on osteoporosis and fracture repair.

[0030] Duhuo: Medicinal properties: pungent, bitter, warm. It can dispel rheumatism and relieve pain. It can relieve rheumatic bone pain and has a certain effect on soft tissue injury and arthritis pain.

[0031] Qianghuo: Medicinal properties: pungent, bitter, warm. Can dispel rheumatism, dispel cold and relieve pain. Used to treat bone and joint pain caused by rheumatism, and has a synergistic analgesic effect when used with Duhuo.

[0032] Eucommia ulmoides: Medicinal properties: sweet, warm. It can nourish the liver and kidneys, strengthen tendons and bones. It can enhance bone strength, stimulate osteoblast activity, and promote fracture healing; it has a good improvement effect on osteoporosis.

[0033] Astragalus: Medicinal properties: sweet, slightly warm. It can replenish qi and strengthen the exterior, promote diuresis and reduce swelling, and promote tissue regeneration. It can enhance immune function, promote soft tissue repair at the site of bone injury, and accelerate the disappearance of blood stasis.

[0034] Panax notoginseng: Medicinal properties: sweet, slightly bitter, warm. It can promote blood circulation and stop bleeding, reduce swelling and relieve pain. It is widely used for traumatic injuries, fractures, and blood stasis and swelling; it can promote blood circulation and remove blood stasis, stop bleeding and reduce swelling, and is suitable for the treatment of bone injuries at all stages.

[0035] Natural copper: Medicinal properties: pungent, flat. It can heal bones and tendons, promote blood circulation and dissipate blood stasis. It promotes fracture healing and improves the problem of blood stasis during bone healing; it is often used for bone injuries such as fractures and dislocations.

[0036] Xuejie: ​​Medicinal properties: sweet, salty, flat. It can promote blood circulation and relieve pain, stop bleeding and promote tissue regeneration. It has strong blood circulation, blood stasis and hemostasis functions, and has a significant effect on repairing soft tissue injuries in bone injuries.

[0037] Catechu: Medicinal properties: bitter, astringent, flat, can stop bleeding, promote tissue regeneration, and astringe wounds. Helps soft tissue wounds heal, reduces bleeding, and prevents wound infection.

[0038] Angelica: Medicinal properties: sweet, pungent, warm. It can replenish blood and activate blood circulation, regulate menstruation and relieve pain. It promotes blood production, improves microcirculation in bone injury areas, and cooperates with Panax notoginseng to strengthen blood circulation and blood stasis absorption.

[0039] Radix Rehmanniae: Medicinal properties: sweet, bitter, cold. It can clear away heat and cool blood, nourish yin and promote the production of body fluid. It can eliminate inflammatory reactions at the site of bone injury, nourish yin and blood, and improve fever symptoms during the healing process of bone injury.

[0040] Gentiana macrophylla: Medicinal properties: pungent, bitter, neutral. Can dispel rheumatism, relax tendons and tendons. Relieve rheumatic pain, and promote the recovery of bone joints and muscle tissues.

[0041] Saposhnikovia divaricata: Properties: pungent, sweet, neutral. It can dispel wind, relieve symptoms, and relieve pain. It can prevent the invasion of wind, cold, and dampness, and accelerate the recovery of bone injuries.

[0042] Earthworm: Medicinal properties: salty, cold. It can dredge meridians and relieve pain, clear away heat and relieve asthma. It can accelerate blood circulation and reduce swelling and pain in bone injuries.

[0043] Centipede: Medicinal properties: pungent, warm, poisonous. It can dredge meridians, relieve pain, and eliminate rheumatism. It is used to relieve stubborn rheumatic pain and pain after fracture reduction.

[0044] Whole worm: Medicinal properties: pungent, flat, toxic. It can dredge meridians and relieve pain, dispel wind and disperse knots. It has a good effect on old blood stasis and joint stiffness.

[0045] Earthworm: Medicinal properties: salty, cold. It can break blood and remove blood stasis, repair tendons and bones. It can accelerate the absorption of blood stasis and the regeneration of new tissues, and promote the healing of fractures.

[0046] Licorice: Medicinal properties: sweet, neutral. It can harmonize various medicines, clear away heat and detoxify. It can reduce the inflammatory response of the bone injury site and alleviate the toxicity of other medicinal materials.

[0047] Frankincense: Medicinal properties: pungent, bitter, warm. It can promote blood circulation and relieve pain, promote tissue regeneration and heal sores. It promotes blood circulation and tissue repair, and reduces swelling caused by blood stasis.

[0048] Myrrh: Medicinal properties: bitter, flat. It can promote blood circulation and relieve pain, reduce swelling and promote tissue regeneration. When used with frankincense, it has significant effects of promoting blood circulation, removing blood stasis and relieving pain.

[0049] Huang Dan: Medicinal properties: Mineral medicine, astringent. It can detoxify, reduce swelling, remove dead tissue and promote tissue regeneration. As a plaster matrix, it promotes wound healing and helps the plaster to adhere.

[0050] Sesame oil: acts as a solvent to extract the active ingredients in the medicinal materials and help the plaster take shape.

[0051] Beeswax, rosin (other auxiliary materials, 800g): can adjust the hardness of the plaster, enhance its viscosity, and ensure that the plaster is firmly and comfortably applied.

[0052] The preparation method of the above-mentioned plaster comprises the following steps: (a) Formula preparation: weigh peach kernel, safflower, Chuanxiong, Chuanxiong, Drynaria, Angelica dahurica, Notopterygium wilfordii, Eucommia ulmoides, Astragalus, Panax notoginseng, natural copper, Sanguisorba officinalis, catechu, Angelica sinensis, Radix Rehmanniae, Gentiana macrophylla, Saposhnikovia divaricata, earthworm, centipede, whole worm, earthworm, liquorice, frankincense, myrrh, yellow lead, sesame oil and other auxiliary materials; (b) Soaking medicinal materials: Soak sesame oil, peach kernel, safflower, Chuanxiong, Chuanxiong, Drynaria, Angelica dahurica, Notopterygium wilfordii, Eucommia bark, natural copper and liquorice in an iron pot for 7 to 8 days to release fat-soluble components; (c) Heating and cooking Heat the soaked herbs and sesame oil over low heat, stirring and controlling the temperature; Then add astragalus, notoginseng, angelica, raw rehmannia, gentiana macrophylla, saposhnikovia, earthworm, centipede, whole insect, earthworm, dragon's blood, catechu, frankincense, myrrh and other auxiliary materials in turn, and continue to boil and stir until the medicinal materials are fried yellow but not carbonized; (d) Filtration and clarification: remove the drug residue and filter out the oil; (e) Concentrating and boiling the oil: until the smoke produced by the liquid medicine changes from green smoke and black smoke to white smoke, then gradually add yellow lead, stirring while adding, and check the temperature by dripping water to ensure that the ointment is suitable and the ointment is of appropriate hardness and softness, which is easy to shape and has stable efficacy; (f) Cooling and detoxification: After cooling the ointment, soak it in cold water for 7 days to remove the fire poison; (g) Spreading plaster: forming into plaster sheets suitable for different parts of the body.

[0053] The optimal temperature for testing the heat by the dripping method is controlled between 230℃ and 280℃ to ensure the full integration of yellow ochre and the medicinal solution and avoid carbonization of the medicinal materials.

[0054] In steps (c) and (e), a wet willow stick or a wet locust stick is used and stirring is continued in the same direction.

[0055] In step (e), when the water drops form beads and do not disperse, it indicates that the consistency of the liquid medicine is appropriate, the yellow lead and the liquid medicine are fully integrated, and the viscosity and efficacy of the finished plaster are both in an appropriate state.

[0056] In this embodiment, the fat-soluble components of the medicinal materials are fully extracted by standing and soaking for 7 to 8 days, avoiding the waste of the effective ingredients of the medicinal materials. The slow fire boiling and dripping method detection process ensures that the efficacy of the medicinal materials is not destroyed by high temperature, while ensuring that the hardness of the finished plaster is moderate. Cooling and detoxification process: Soaking in cold water for 7 days can significantly reduce the residual fire poison and improve the safety and efficacy stability of the plaster. Reasonable molding: Plaster pieces of different sizes are convenient for precise application according to the location of the lesion, which improves the convenience in actual use.

[0057] Embodiment 1 In order to verify the effects of different key components in the plaster formula on the performance of treating bone injuries, experimental groups were designed. Each experimental group changed the proportion of a key component to specifically enhance a specific therapeutic effect.

[0058] Experimental group 1: used to enhance the effect of promoting blood circulation and removing blood stasis Components: Peach kernel 60g, safflower 50g, Chuanxiong 50g, Chuanxiong 60g, bone drynbu 60g, Duhuo 120g, Qianghuo 120g, Eucommia 50g, Astragalus 50g, Panax notoginseng 100g, natural copper 50g, Sanguisorba officinalis 40g, catechu 40g, Angelica 90g, Rehmannia glutinosa 90g, Gentiana macrophylla 100g, Saposhnikovia divaricata 100g, earthworm 60g, centipede 20g, whole worm 30g, earthworm 40g, licorice 60g, frankincense 60g, myrrh 60g, yellow ochre 3750g, sesame oil 7500g, other auxiliary materials 800g Experimental group 2: used to replenish blood and improve microcirculation Components: 60g peach kernel, 50g safflower, 50g chuanxiong, 60g chuanxiong, 60g bone drynbu, 120g angelica, 120g qianghuo, 50g eucommia, 50g astragalus, 90g panax notoginseng, 50g natural copper, 40g blood clotting, 40g catechu, 100g angelica, 100g raw earth, 100g qinjiao, 100g siler, 60g earthworm, 20g centipede, 30g whole worm, 40g earthworm, 60g licorice, 60g frankincense, 60g myrrh, 3750g yellow ochre, 7500g sesame oil, 800g other auxiliary materials Experimental Group 3: Used to enhance bone repair Components: Peach kernel 60g, safflower 50g, Chuanxiong 50g, Chuanxiong 60g, bone drynbu 60g, Duhuo 120g, Qianghuo 120g, Eucommia 60g, Astragalus 50g, Panax notoginseng 90g, natural copper 60g, Sanguisorba officinalis 40g, catechu 40g, Angelica 90g, Rehmannia glutinosa 90g, Gentiana macrophylla 100g, Saposhnikovia divaricata 100g, earthworm 60g, centipede 20g, whole worm 30g, earthworm 40g, licorice 60g, frankincense 60g, myrrh 60g, yellow ochre 3750g, sesame oil 7500g, other auxiliary materials 800g Experimental Group 4: Used to promote blood stasis absorption and tissue repair Components: 60g peach kernel, 50g safflower, 50g chuanxiong, 60g chuanxiong, 60g bone drynaria, 120g angelica, 120g qianghuo, 50g eucommia, 50g astragalus, 90g panax notoginseng, 50g natural copper, 40g blood clotting, 40g catechu, 90g angelica, 90g raw earth, 100g qinjiao, 100g siler, 60g earthworm, 20g centipede, 30g whole worm, 50g earthworm, 60g licorice, 60g frankincense, 60g myrrh, 3750g yellow ochre, 7500g sesame oil, 800g other auxiliary materials Experimental Group 5: Used for comprehensive treatment of bone injuries, with the functions of promoting blood circulation and removing blood stasis, replenishing blood and promoting new blood, bone repair and tissue regeneration Components: 60g peach kernel, 50g safflower, 50g chuanxiong, 60g chuanxiong, 60g bone drynbu, 120g angelica, 120g qianghuo, 60g eucommia, 50g astragalus, 100g panax notoginseng, 60g natural copper, 40g blood clotting, 40g catechu, 100g angelica, 100g raw earth, 100g qinjiao, 100g siler, 60g earthworm, 20g centipede, 30g whole worm, 50g earthworm, 60g licorice, 60g frankincense, 60g myrrh, 3750g yellow ochre, 7500g sesame oil, 800g other auxiliary materials Preparation steps: (same for five experimental groups) Step 1: Recipe Preparation Weighing of raw materials: Weigh the medicinal materials according to the following proportions: Peach kernel, safflower, chuanxiong, chuanxiong, drynaria, angelica, notoginseng, eucommia, astragalus, panax notoginseng, natural copper, blood clotting, catechu, angelica, radix rehmanniae, gentiana macrophylla, siler, earthworm, centipede, whole worm, earthworm, liquorice, frankincense, myrrh, yellow ochre, sesame oil, beeswax and rosin (other auxiliary materials).

[0059] Step 2: Soaking herbs Add sesame oil and the following herbs into the wok: Peach kernel, safflower, Chuanxiong, Chuanxiong, Drynaria, Angelica dahurica, Notopterygium wilfordii, Eucommia ulmoides, natural copper, and licorice.

[0060] Soaking conditions: Soak for 7 days at room temperature to fully release the fat-soluble components in the medicinal materials and prepare for subsequent decoction.

[0061] Note: Make sure all the herbs are immersed in sesame oil to avoid oxidation caused by exposure to air.

[0062] Step 3: Heat and cook Initial heating: Place the soaked iron pan on the fire, heat it gradually over low heat, and stir continuously to control the oil temperature within an appropriate range to avoid charring of the medicinal materials.

[0063] Add other herbs: When the temperature stabilizes, add the following herbs in order: Astragalus, Panax notoginseng, Chinese angelica, Rehmannia, Gentiana macrophylla, Saposhnikovia divaricata, earthworm, centipede, whole insect, earthworm, Sanguisorba officinalis, catechu, frankincense, and myrrh.

[0064] Stirring method: Use a wet willow stick or a wet locust tree stick to stir slowly in the same direction to ensure that the medicinal materials are fried until yellow but not carbonized, so as to fully release the medicinal properties.

[0065] Cooking time: Continue heating and stirring until the herbs are completely fried yellow and the medicinal properties are absorbed into the oil.

[0066] Step 4: Filtration and clarification Use a strainer to scoop out the residue after boiling, and filter it with fine gauze to remove impurities in the medicinal liquid to obtain clarified medicinal oil.

[0067] Note: The filtration process should be quick to avoid the subsequent operations being affected by the cooling of the liquid medicine.

[0068] Step 5: Concentrate Continue to heat the medicinal liquid until it boils, then simmer it over low heat.

[0069] Smoke observation: During the brewing process, pay attention to the smoke produced by the medicine liquid, which gradually changes from green smoke and black smoke to white smoke.

[0070] Add yellow lead: When the smoke turns into white smoke, gradually and slowly add yellow lead, stirring while adding to ensure that the yellow lead is completely dissolved and evenly distributed.

[0071] Testing the heat by the water dripping method: When the oil dropped into cold water forms beads and does not disperse, it indicates that the concentrated boiling is complete.

[0072] Step 6: Cooling and detoxification Allow the prepared plaster to cool naturally to room temperature.

[0073] Cold water soaking: Soak the cooled plaster in cold water for 7 days to remove fire poison.

[0074] Note: Change the cold water once a day to ensure that the fire poison is completely removed.

[0075] Step 7: Spread the plaster Place the cooled plaster on a plaster spreading tool and make plaster sheets of different sizes and shapes as needed.

[0076] Operating conditions: Spread at room temperature (20-30°C) to avoid excessively high temperatures that may cause the plaster to soften or delaminate.

[0077] Finished product storage: Store the prepared plaster tablets in a dry, cool place to avoid moisture or high temperature.

[0078] In this embodiment Experimental group 1 is used to enhance the effect of promoting blood circulation and removing blood stasis This group mainly highlights the blood-activating and blood-stasis-removing function of the plaster, and is suitable for bone injuries caused by blood stasis, such as bruises, blood stasis, swelling and pain, soft tissue contusion, etc.

[0079] Among them, Panax notoginseng is a commonly used "hemostatic and stasis-removing" drug in traditional Chinese medicine, which has the effects of promoting blood circulation and removing blood stasis, relieving pain and reducing swelling. In bone injuries, Panax notoginseng can improve local microcirculation, accelerate the absorption of blood stasis and the formation of new blood vessels, and promote tissue repair and fracture healing. A high content of Panax notoginseng combined with peach kernel and safflower can form a powerful combination of promoting blood circulation and removing blood stasis, quickly relieving swelling and pain caused by blood stasis and local inflammation.

[0080] Therefore, the content of Panax notoginseng was adjusted to 100g, making it play a dominant role in promoting blood circulation and removing blood stasis. At the same time, it was combined with peach kernel and safflower to further enhance the effect of promoting blood circulation and removing blood stasis.

[0081] Experimental group 2 was used to replenish blood and improve microcirculation This group focuses on enhancing the blood-replenishing function of the plaster, while also having the effect of improving microcirculation. It is suitable for bone injury repair and inflammation relief caused by insufficient qi and blood, such as bone marrow repair after fracture or anemia patients.

[0082] Among them, angelica has the effects of nourishing blood and activating blood circulation, regulating menstruation and relieving pain, moistening dryness and lubricating intestines, and is a commonly used medicine in traditional Chinese medicine blood-tonifying prescriptions. In bone injury repair, angelica can promote blood production, improve local blood supply deficiency, and help damaged tissues repair quickly. Shengdi: clears heat and cools blood, nourishes yin and nourishes blood, and is used for blood deficiency, yin deficiency, and heat bruises. Shengdi and angelica can balance the needs of blood supplementation and inflammation relief, and are especially suitable for bone injury patients with qi and blood deficiency. The two work together to improve the local microcirculation of bone injuries while increasing the repair capacity of bones and soft tissues.

[0083] Therefore, the content of angelica and rehmannia was increased to 100g, focusing on replenishing blood and improving local blood circulation.

[0084] Experimental group 3 was used to enhance bone repair This group focuses on promoting bone repair and is suitable for bone damage caused by fractures or osteoporosis, as well as the regeneration of bone matrix during bone healing. The content of Eucommia ulmoides and natural copper is increased to strengthen the ability of bone repair.

[0085] Among them, Eucommia ulmoides has the function of nourishing the liver and kidneys, strengthening the tendons and bones, and is an important component of traditional orthopedic prescriptions. Eucommia ulmoides contains ingredients such as eucommia gum and eucommia phenol, which can stimulate the proliferation of osteoblasts, promote fracture healing, and enhance bone density to prevent osteoporosis. Natural copper has the functions of promoting blood circulation, removing blood stasis, setting bones and reducing swelling, and is especially suitable for the initial healing of fractures and bone reconstruction. High content of natural copper can accelerate the formation of callus and increase the speed of fracture healing. The combination of the two strengthens the repair ability of bones, and has a significant effect on patients with fractures or osteoporosis.

[0086] Therefore, the content of Eucommia ulmoides and natural copper is increased to 60g to enhance the ability of bone repair.

[0087] Experimental group 4 is used to promote blood stasis absorption and tissue repair This group mainly increases the proportion of earthworms, promotes blood stasis absorption, improves local inflammatory reactions, and accelerates tissue repair. It is suitable for the healing of swelling and pain caused by blood stasis and tissue damage after injury.

[0088] Among them, earthworms have the functions of breaking blood and removing blood stasis, repairing tendons and bones, and can significantly accelerate the absorption of blood stasis and the formation of new blood vessels, while reducing local swelling and pain. In the treatment of bone injuries, earthworms can relieve local inflammation caused by blood stasis and promote the repair of damaged soft tissues. A higher content of earthworms can form a strong blood stasis absorption capacity, improve blood circulation in the bone injury area, and accelerate healing.

[0089] Therefore, the content of earthworms is increased to 50g to enhance the effect of breaking blood and removing blood stasis.

[0090] Experimental group 5 is used for comprehensive treatment of bone injuries Experimental group 5 contains the standard proportions of all components, taking into account the functions of promoting blood circulation and removing blood stasis, replenishing blood and promoting new blood, repairing bone and regenerating tissue. It is the optimal formula of this plaster and is suitable for the treatment of various types of bone injuries.

[0091] The balanced ratio of the components makes it comprehensive in efficacy and suitable for various diseases such as traumatic injuries, fracture repair, osteoporosis, soft tissue injuries, etc.

[0092] Moreover, the proportions of all components are kept in the optimal range, not focusing on a single therapeutic effect but emphasizing comprehensiveness.

[0093] Example 2: Verification of the effect of experimental group plaster in the treatment of bone injuries Purpose Example 2 Animal experiments were performed to verify the differences in the efficacy of the plaster formulas of experimental groups 1 to 5, focusing on the following therapeutic indicators: Blood stasis disappearance rate: evaluate the effect of plaster in promoting blood circulation and removing blood stasis.

[0094] Local blood flow: verify the effect of plaster on improving local microcirculation.

[0095] Changes in bone density: Observing the effect of plasters in bone repair.

[0096] Swelling subsidence time: evaluate the effect of the plaster on blood stasis absorption and tissue repair.

[0097] Tissue repair score: Comprehensive evaluation of the efficacy of plasters on tissue repair at the site of bone injury Experimental design Experimental subjects Animal selection: Adult male SD rats, weighing 200-250 g, 8-10 weeks old.

[0098] Quantity: 100 in total, divided into 5 groups, 20 in each group.

[0099] Experimental model: Fracture model: Transverse femoral fracture was used to simulate bone injury.

[0100] Soft tissue injury model: Soft tissue contusion and stasis block were simulated by blunt impact on the hind limb muscles.

[0101] Experimental Grouping Experimental group 1: Verify the effect of promoting blood circulation and removing blood stasis (formula with high content of Panax notoginseng).

[0102] Experimental Group 2: Verify the effects of enriching blood and improving microcirculation (prescription with high angelica and raw rehmannia).

[0103] Experimental Group 3: Verify the bone repair effect (high Eucommia ulmoides and natural copper formula).

[0104] Experimental Group 4: Verify the blood stasis absorption and tissue repair effects (high earth element formula).

[0105] Experimental Group 5: Comprehensive Treatment Effect (Comprehensive Formula) Experimental procedures Step 1: Establishment of bone injury model Fracture model: Under general anesthesia, a transverse fracture was created in the midshaft of the right femur using a bone saw.

[0106] The fracture gap was approximately 2 mm, and no fixation was used to simulate the natural healing process of open fractures.

[0107] Model standardization was confirmed by X-ray after fracture.

[0108] Soft tissue injury model: Under anesthesia, the right hindlimb muscle was struck three times (with 1 second interval) with a force of 15 N using a 4 mm metal blunt instrument.

[0109] The injured area is approximately 1cm², with bruising and swelling visible to the naked eye.

[0110] Step 2: Plaster application and experimental conditions Plaster application: The corresponding plaster was applied to the bone injury site of each group of rats and changed once a day.

[0111] Use gauze to fix the plaster to prevent the rat from biting it.

[0112] Environmental Control: Temperature: 22±2℃.

[0113] Humidity: 50%~60%.

[0114] Light: 12 h light / dark cycle.

[0115] Feeding: Free access to standardized feed and drinking water.

[0116] Observation period: The experimental period was 30 days, and the experimental data were recorded on the 7th, 14th, 21st and 30th days.

[0117] Step 3: Data Logging Eczema area reduction rate (%): The stasis area was measured using imaging software and the resolution rate was calculated by comparing it with the initial area.

[0118] Local blood flow (ml / min): Laser Doppler flowmetry was used to measure the blood flow at the site of bone injury.

[0119] Change in bone density (g / cm³): Dual-energy X-ray absorptiometry (DXA) was used to measure bone density at the fracture site.

[0120] Time for swelling to subside (days): The circumference of the limb was measured with a tape measure, and the time required for the swelling to completely subside was recorded.

[0121] Tissue repair score (0-10 points): Observe cell proliferation, inflammatory response, angiogenesis and other repair conditions through tissue sections (0 is no repair, 10 is complete repair) The experimental results are shown in Table 1. Table 1 Group Eczema area reduction rate (%) Local blood flow (ml / min) Changes in bone density (g / cm³) Time for swelling to subside (days) Tissue repair score (0-10) Experimental Group 1 85±5 12±1 0.65±0.02 10±2 6±1 Experimental Group 2 75±5 15±2 0.72±0.03 12±3 7±1 Experimental Group 3 70±4 10±1 0.80±0.02 15±3 8±1 Experimental Group 4 80±5 13±1 0.68±0.02 9±2 7±1 Experimental Group 5 90±4 16±2 0.85±0.03 8±1 9±1 Experimental results analysis The rate of blood stasis area disappearance: Experimental Group 1 and Experimental Group 5 performed best in the effect of eliminating blood stasis, which were 85% and 90% respectively, verifying the significant effect of high content of Panax notoginseng or comprehensive formula on promoting blood circulation and removing blood stasis.

[0122] Local blood flow: Experimental Group 2 and Experimental Group 5 had significant effects in improving microcirculation, which were 15 ml / min and 16 ml / min respectively, indicating that increasing the proportion of Angelica sinensis and Rehmannia glutinosa was helpful in improving blood flow.

[0123] Bone density changes: Experimental groups 3 and 5 performed outstandingly in promoting bone repair, with bone density changes of 0.80 g / cm³ and 0.85 g / cm³, respectively, indicating that the Eucommia and natural copper formula can significantly promote callus formation.

[0124] Swelling subsides time: The swelling subsidence time in experimental group 4 and experimental group 5 was the shortest, which was 9 days and 8 days respectively, indicating that earthworms and the comprehensive formula can significantly accelerate the absorption of blood stasis and tissue repair.

[0125] Tissue Repair Score: Experimental group 5 had the highest score in tissue repair (9 points), indicating that the comprehensive formula has advantages in comprehensively improving the therapeutic effect of the plaster.

[0126] Experimental Conclusion Single function verification: Experimental groups 1 to 4 showed significant performance in single functions such as promoting blood circulation and removing blood stasis, replenishing blood and improving microcirculation, bone repair, blood stasis absorption and tissue repair, and are suitable for targeted treatment.

[0127] Comprehensive functional verification: Experimental Group 5 performed well in all indicators, indicating that the comprehensive formula can fully cover the needs of bone injury treatment and is suitable for patients with various types of bone injuries.

[0128] Application value: Experimental Group 5 is a fully optimized plaster formula with broad application prospects. It is the best choice for treating bone injuries such as fractures and soft tissue injuries.

[0129] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A plaster for treating bone injuries, characterized in that: Including the following ingredients: Peach kernel, safflower, chuanxiong, chuanxiong, drynaria, angelica, angelica dahurica, angelica notoginseng, natural copper, blood clotting, catechu, angelica sinensis, radix rehmanniae, gentiana macrophylla, siler, earthworm, centipede, whole worm, earthworm, liquorice, frankincense, myrrh, yellow ochre, sesame oil and other auxiliary materials.

2. A plaster for treating bone injuries according to claim 1, characterized in that: The raw materials include, by mass: Peach kernel 55-65g, safflower 45-55g, Chuanxiong 45-55g, Chuanxiong 55-65g, Drynaria 55-65g, Duhuo 115-125g, Qianghuo 115-125g, Eucommia 50-60g, Astragalus 45-55g, Panax notoginseng 90-100g, Natural copper 50-60g, Sanguisorba officinalis 35-45g , catechu 35-45g, angelica 90-100g, raw rehmannia 90-100g, qinjiao 95-105g, siler 95-105g, earthworm 55-65g, centipede 15-25g, whole insect 25-35g, earthworm 40-50g, licorice 55-65g, frankincense 55-65g, myrrh 55-65g, yellow lead 3700-3800g, sesame oil 7400-7600g, other auxiliary materials 750-850g.

3. A plaster for treating bone injuries according to claim 2, characterized in that: The specific quality of the raw materials is: 60g peach kernel, 50g safflower, 50g chuanxiong, 60g chuanxiong, 60g drynaria, 120g angelica, 120g angelica dahurica, 60g eucommia, 50g astragalus, 100g panax notoginseng, 60g natural copper, 40g blood clotting, 40g catechu, 100g angelica, 100g raw rehmannia, 100g qinjiao, 100g siler, 60g earthworm, 20g centipede, 30g whole insect, 50g earthworm, 60g licorice, 60g frankincense, 60g myrrh, 3750g yellow lead, 7500g sesame oil, and 800g other auxiliary materials.

4. A plaster for treating bone injuries according to claim 3, characterized in that: The other auxiliary materials include one or more of excipients or stabilizers. The excipients and stabilizers are beeswax and rosin, which are used to adjust the viscosity and hardness of the plaster, with a total weight of 800g.

5. A method for preparing a plaster for treating bone injuries, for preparing a plaster for treating bone injuries according to any one of claims 1 to 4, characterized in that: The following steps are involved: (a) Formula preparation: weigh peach kernel, safflower, Chuanxiong, Chuanxiong, Drynaria, Angelica dahurica, Notopterygium wilfordii, Eucommia ulmoides, Astragalus, Panax notoginseng, natural copper, Sanguisorba officinalis, catechu, Angelica sinensis, Radix Rehmanniae, Gentiana macrophylla, Saposhnikovia divaricata, earthworm, centipede, whole worm, earthworm, liquorice, frankincense, myrrh, yellow lead, sesame oil and other auxiliary materials; (b) Soaking medicinal materials: Soak sesame oil, peach kernel, safflower, Chuanxiong, Chuanxiong, Drynaria, Angelica dahurica, Notopterygium wilfordii, Eucommia bark, natural copper and liquorice in an iron pot for 7 to 8 days to release fat-soluble components; (c) Heating and cooking Heat the soaked herbs and sesame oil over low heat, stirring and controlling the temperature; Then add astragalus, notoginseng, angelica, raw rehmannia, gentiana macrophylla, saposhnikovia, earthworm, centipede, whole insect, earthworm, dragon's blood, catechu, frankincense, myrrh and other auxiliary materials in turn, and continue to boil and stir until the medicinal materials are fried yellow but not carbonized; (d) Filtration and clarification: remove the drug residue and filter out the oil; (e) Concentrating and boiling the oil: until the smoke produced by the liquid medicine changes from green smoke and black smoke to white smoke, then gradually add yellow lead, stirring while adding, and check the temperature by dripping water to ensure that the ointment is suitable and the ointment is of appropriate hardness and softness, which is easy to shape and has stable efficacy; (f) Cooling and detoxification: After cooling the ointment, soak it in cold water for 7 days to remove the fire poison; (g) Spreading plaster: forming into plaster sheets suitable for different parts of the body.

6. The method for preparing a plaster for treating bone injuries according to claim 5, characterized in that: The optimal temperature for detecting the temperature by the dripping method is controlled between 230° C. and 280° C. to ensure the full fusion of yellow lead and the medicinal solution and avoid carbonization of the medicinal material.

7. The method for preparing a plaster for treating bone injuries according to claim 5, characterized in that: In steps (c) and (e), a wet willow stick or a wet locust stick is used and stirring is continued in the same direction.

8. The method for preparing a plaster for treating bone injuries according to claim 5, characterized in that: In step (e), when the water drops form beads and do not disperse, it indicates that the consistency of the medicinal solution is appropriate, the yellow lead and the medicinal solution are fully integrated, and the viscosity and efficacy of the finished plaster are both in an appropriate state.

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