490results about How to "Prevent proliferation" patented technology

This invention belongs to the field of biopharmaceuticals and provides a keratin YK93-6, its encoding nucleic acid molecule, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or whose genome integrates the nucleic acid molecule, as well as a preparation method and a pharmaceutical composition thereof. It also provides the application of the above-mentioned keratin YK93-6 and other products in the preparation of drugs for treating benign prostatic hyperplasia, lymphoma, melanoma, analgesia, lactation, breast cancer, lung cancer, uterine fibroids, coagulation, etc.

The invention provides traditional Chinese medicine fermented disaccharide encapsulated nano anti-dandruff, hair-growing and oil-controlling shampoo and a preparation method, and relates to the field of daily chemical products, and the shampoo comprises the following components: a compound fermentation product, lactobacillus crispatus, lactobacillus plantarum, a disaccharide activity protection system, a basic component and a nano oil-controlling component; the compound leavening is prepared from cacumen biotae, radix polygoni multiflori, radix ginseng, fructus cnidii and orchid; the disaccharide activity protection system comprises maltotetraose and trehalose; the disaccharide activity protection system wraps a fermented material formed by fermenting the compound fermentation product, the lactobacillus crispatus and the lactobacillus plantarum to form a disaccharide glassy state layer; the nano oil control component is prepared from calamine powder and chitosan-sodium alginate; the basic component is prepared from tea bran, radix sophorae flavescentis, herba ecliptae, radix notoginseng, fructus ligustri lucidi, tea saponin microcapsules and tremella polysaccharide. According to the invention, through fermentation conversion of the orchid, disaccharide glassy state protection and slow release of the nano calamine, activity enhancement, stable retention and accurate release are realized, and the effects of removing dandruff, relieving itching, controlling oil and growing hair are achieved.

The invention relates to a cluster unmanned aerial vehicle communication method based on a multi-dimensional key encryption and decryption algorithm. The method comprises the following steps: acquiring unique identifiers of an unmanned aerial vehicle array and marshalling; extracting a single-user key of the unmanned aerial vehicle in the target group, and obtaining a key element by using a multi-dimensional key algorithm; generating an action instruction according to a preset coding rule, encrypting the action instruction, and combining the action configuration classification area to obtain a remote control instruction data packet; transmitting the remote control instruction data packet through a broadcasting mechanism, and receiving the remote control instruction data packet by the unmanned aerial vehicle through a monitoring mechanism; filtering and analyzing the received data packet to obtain a configuration data unit matched with the unmanned aerial vehicle marshalling; extracting a key element based on the configuration data unit, and calculating to obtain an original key; decrypting the action element encryption value to restore the action instruction, and executing the instruction after verification; the execution process of the action instruction is monitored in real time, and abnormal conditions are processed; the cluster unmanned aerial vehicle communication method using multi-dimensional key encryption and decryption is realized.

The invention discloses an aeroacoustic wind tunnel corner noise elimination flow deflector, a flow deflector group and a design method, and belongs to the technical field of aeroacoustic wind tunnel test equipment. The corner flow deflector aims at solving the technical problems that an existing corner flow deflector cannot give consideration to aerodynamic performance and noise elimination performance, and a special shape design method and a combination application scheme are lacked. The noise elimination flow deflector is of an integrated structure formed by sequentially connecting a semi-oval front edge, a front straight section, an arc section, a rear straight section and a wedge-shaped tail edge, and key parameters of the upper profile and the lower profile are designed in an associated mode. The flow deflector set is formed by combining and installing at least two noise elimination flow deflectors according to a specific rule, and a uniform-section airflow channel is formed. According to the design method, coupling optimization of the noise elimination amount and the aerodynamic performance is achieved through a parameterized design process in combination with the Picrov formula, and the design method has the advantages of being high in noise elimination efficiency, small in aerodynamic loss and good in airflow uniformity, is suitable for a symmetric corner aerodynamic acoustic wind tunnel and can be widely applied to aerodynamic noise tests in the fields of aviation, automobiles and the like.

This invention belongs to the field of biopharmaceuticals and provides a keratin YK93-9, its encoded nucleic acid molecule, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or whose genome integrates the nucleic acid molecule, as well as a preparation method and a pharmaceutical composition thereof. It also provides the application of the above-mentioned keratin YK93-9 and other substances in the preparation of drugs for treating lung cancer, lymphoma, breast cancer, melanoma, uterine fibroids, benign prostatic hyperplasia, etc.

The invention relates to the technical field of plastic forming, and discloses a plastic leftover material forming process of a layered compaction structure, which comprises the following steps: S1, raw material pretreatment: selecting a new plastic material meeting performance requirements, drying, mixing with pretreated recycled material particles in proportion, uniformly stirring, and feeding into a raw material storage tank for later use; s2, melting and injection molding: feeding the mixed raw materials into an injection molding machine, heating in different areas through a charging barrel, and stirring and melting into a melt through a screw rod; the die set is arranged, through an immediate leftover material separation and recovery system, the cut leftover materials can be rapidly recycled, soil and water pollution caused by leftover material accumulation is avoided, meanwhile, waste of plastic raw materials is reduced, and the development concepts of green manufacturing and circular economy are met. Due to the sealing protection design of the die set, pollution caused by melt leakage is avoided, and diffusion of dust and harmful gas is reduced through the sealing structure of the movable groove.

The application discloses a kind of bathroom cabinet processing plate waste crushing recycling equipment, including crushing box, fixed blade is equidistantly arranged between the inner surface of longitudinal two sides of crushing box, two first rotary shafts are symmetrically arranged between the inner surface of transverse two sides of crushing box, rotary blade is cross arranged between the fixed blade of first rotary shaft, transmission gear is installed at one end of two first rotary shafts and passes through crushing box, transmission gear is engaged, and driving motor is arranged on the outer surface of transverse side of crushing box.The beneficial effects of the present application are:the present application is reasonable in design, and the overall structure is stable and firm, which can not only realize the crushing and recycling of plate waste generated during the production and processing of bathroom cabinet, but also avoid the floating of debris and dust generated during the crushing and recycling of plate waste to the surrounding air, ensure the air quality of surrounding environment and the health of operators, and the crushed plate waste can be filled into the storage tank for centralized treatment.

The present application relates to livestock health monitoring technical field, especially in a kind of remote monitoring system of pig disease data can be counted, including: image acquisition module: for continuously obtaining piglet image information, the image information is the continuous image information of piglet and piglet living environment collected every second;Data processing module: the real-time analysis processing data is used for the pixel level accurate extraction analysis of the image information obtained, obtains the contour of image pig and the size data of object in environment;Through data analysis piglet today eating time length condition, judge eating amount through waistline change after eating;And through piglet body data combine eating and excretion data carry out pig health state determination, solve the discovery of early characteristics such as anorexia, body change, excretion anomaly caused by determining pig potential epidemic disease, to provide important data support for veterinarian treatment according to symptoms, solve the problem of too long time of determining pig anorexia reason.

The application discloses an organic compound or a pharmaceutically acceptable salt thereof, and provides the organic compound or the pharmaceutically acceptable salt thereof and a pharmaceutical composition containing the same, wherein the organic compound is independently selected from the following compounds:

The utility model discloses a garbage recycling bin for municipal environmental protection engineering, and relates to the technical field of garbage recycling bins, the garbage recycling bin comprises a shell, and a disinfection mechanism is arranged in the shell; the disinfection mechanism comprises a disinfectant storage box arranged on the inner wall of the shell through a fixing rod, and a plurality of atomizing nozzles are arranged on the bottom surface of the disinfectant storage box and used for spraying out disinfectant; the disinfection mechanism further comprises a spraying and pressing assembly. According to the garbage recycling device, when garbage is thrown into the recycling box, opening of the inlet door can be in linkage with the transmission assembly, the pressing plate is pushed to be pressed downwards, then disinfectant in the disinfectant storage box is sprayed out through the atomization spray head under the action of the push rod and the piston head, the garbage which is just thrown into the recycling box is disinfected in time, manual intervention is not needed, and the environment is protected. And viruses and bacteria are effectively prevented from diffusing into the air due to runaway in the garbage treatment process, so that the public health safety level is improved.

The application discloses a five-heterocycle compound, a preparation method and application thereof. Specifically disclosed are a compound as shown in formula I, a pharmaceutically acceptable salt or solvate thereof, a composition containing the compound, and a pharmaceutical use of the compound for preparing a drug for treating a disease or disorder related to the mechanism of action of KRAS G12C mutant protein. The five-heterocycle compound in the application has the activity of inhibiting the proliferation of Ba / F3 KRAS-G12C cells, NCI-H358 cells and MIA PaCa-2 cells expressing KRAS G12C mutant protein, and has a good inhibitory effect on the growth of a subcutaneous transplanted tumor of a NCI-H358 nude mouse.

The utility model relates to the technical field of automobile door panel processing, and discloses a welding tool for assembling an automobile door panel, which comprises a machine body, a fixed adjusting component and a protective component are arranged above the machine body, the fixed adjusting component comprises a rectangular frame, and a door panel body is placed on the upper surface of the rectangular frame. According to the welding tool for assembling the automobile door panel, through combination of an air cylinder and a rubber pad, stable clamping of a door panel body is achieved, the rubber pad protects the surface of the door panel from being damaged, the adaptability of equipment to door panels of different sizes is enhanced through a limiting rod and a swing piece, the height of a rectangular frame is adjusted through a traction rope, and the door panel is accurately positioned; the welding assembly supports double-face welding, the efficiency is greatly improved, a protective curtain and a collecting frame are matched with a breathable grid plate, welding smoke is effectively extracted and filtered, the air quality is improved, the health of operators is guaranteed, residues are conveniently collected and discharged through the design of a scraper, impurity retention is avoided, the welding process is optimized through the overall structure, and the production efficiency, the environmental protection property and the safety are improved.

The application discloses a 3-(5-(aminomethyl)-1-oxoisoindoline-2-yl)piperidine-2,6-dione derivative and a synthesis method and application thereof, and relates to a 3-(5-(aminomethyl)-1-oxoisoindoline-2-yl)piperidine-2,6-dione derivative which is a compound with the following general formula (I): wherein R1 is selected from,,,,,,,,, and R2 is selected from,,, and. The compound can significantly inhibit the proliferation of leukemia, multiple myeloma, lymphoma, breast cancer, liver cancer and the like at a low dose (nanomole), can effectively degrade IKZF1, IKZF3, BRD4, GSPT1 and CK1 alpha, and has the prospect of being developed into an anti-tumor drug. The application solves the problem that the existing malignant hematological disease treatment drugs have a high safety risk.

The invention discloses a nonmetal composite hydrogen conveying hose with a multi-form hydrogen blocking layer, and belongs to the technical field of hydrogen conveying hoses, the nonmetal composite hydrogen conveying hose comprises an external pipe, the bottom end of the external pipe is connected with a butt-joint pipe, the bottom end of the butt-joint pipe is connected with a composite hose, the bottom end of the butt-joint pipe is connected with a first sleeve in a penetrating mode, and the top end of the butt-joint pipe is connected with a second sleeve in a penetrating mode; the first sleeve is sleeved on the outer wall of the composite hose, the second sleeve is sleeved on the outer wall of the external pipe, a cavity is arranged in the butt-joint pipe, and a sealing measuring assembly is slidably connected in the cavity of the butt-joint pipe. A complete hydrogen conveying structure is integrally formed by a composite hose, a butt joint pipe and an external pipe, the butt joint pipe is fixedly connected with the composite hose and the external pipe in a sleeving mode through a first sleeve and a second sleeve, an inner cavity provides an installation and sliding space for a test sealing assembly, and the composite hose is of a multi-layer composite structure of a hydrogen conveying pipe, a first hydrogen blocking layer and a second hydrogen blocking layer. And a multi-form hydrogen blocking system with double hydrogen blocking layers and a hydrogen transporting base layer is formed.

The application discloses a coal feeder feeding and conveying device for a thermal power plant, which comprises a shell assembly, a conveying assembly is mounted on the inner wall of the shell assembly, a dust removal assembly is mounted on the outer wall of the shell assembly, a mounting assembly is mounted on the inner wall of the shell assembly, and a driving assembly is mounted on the side wall of the shell assembly. The dust removal assembly is used for absorbing dust in the shell assembly, the driving assembly is used for driving the mounting assembly to move, and the conveying assembly is used for conveying coal. In the application, two fans at the top and the bottom of the mounting box import and export air to the inside of the mounting box, so that the coal dust in the inside of the mounting box can be controlled in the inside of the box body. The dust collector sucks air outward through two air suction pipes, negative pressure is generated in the middle of the mounting box, air flow at both ends of the mounting box is gathered to the middle, and the air flow is discharged by the dust collector, so that the coal dust in the inside of the mounting box can be effectively prevented from spreading to the outside of the box body.

The utility model relates to the technical field of fabric winding and packaging equipment, in particular to anti-wrinkle automatic package packaging equipment for georgette fabric. According to the technical scheme, the georgette fabric production line comprises a georgette fabric body and automatic processing equipment used for packing the georgette fabric body, a tension adjusting roller set used for tensioning and conveying the georgette fabric body is further arranged in the automatic processing equipment, and a steam heating assembly and a heating and drying assembly are further arranged on the automatic processing equipment. The steam heating assembly comprises a steam dispersing pipe used for steam heating of the georgette fabric body, and a steam baffle for preventing steam from diffusing is arranged on the upper periphery of the steam dispersing pipe. The georgette fabric shaping device has double guarantees of steam heating and secondary shaping, steam diffusion is avoided, it is ensured that georgette fabric is heated evenly, wrinkles are effectively eliminated, and the flatness of finished products is improved.

The utility model is suitable for the technical field of paint mist collection, and provides a paint mist rebounding device for cleaning paint. The hollow guide seat is arranged on the collecting shell; the flexible part is arranged on the hollow guide seat; the binding rope is wound and bound on the peripheral side of the flexible part, and the binding rope is connected with a winding mechanism for driving the binding rope to automatically bind the flexible part; the rebound plate is mounted in the collecting shell through an elastic telescopic rod, and the rebound plate faces the hollow guide seat; the inner wall of the collecting shell is connected with a scraping mechanism for automatically cleaning the collecting shell; the device has a good collecting effect.

The application discloses a dihydroquinazolinone-containing N-hydroxy amide compound and a preparation method and application thereof, relates to the technical field of medicinal chemistry, and utilizes the splicing principle to design and synthesize dihydroquinazolinone-containing N-hydroxy amide compounds with novel structures, and the compounds are tested in terms of HDAC6 protein affinity and anti-proliferation activity of cervical cancer cell Siha, and the results show that the compounds E1-E5 have better affinity to the HDAC6 protein, the IC 50 values are 4.1-85.4 nM, wherein the affinity of the compound E4 to the HDAC6 protein is higher than that of a positive control SAHA; and the compounds E1-E5 can better inhibit the proliferation of the cervical cancer cell Siha, the IC 50 values are 2.4-9.3 muM, wherein the activity of the compound E4 is the strongest.

This invention relates to the field of food preservation technology and discloses a liquid preservative for preserving fresh walnut kernels. The preservative comprises a natural preservative, a solubilizing and stabilizing agent, and a solvent. This liquid preservative uses natural phloretin as the preservative component, combined with Tween 80 as a solubilizing and stabilizing agent and ethanol as a solvent. This effectively solves the problems of poor water and oil solubility and inadequate stability of phloretin, allowing it to be stably dispersed in the preservative system and fully exert its antioxidant and antimicrobial effects. Furthermore, the preparation method is simple and easy to implement, and the production process is safe and controllable. It is convenient to use; the preservation of fresh walnut kernels can be achieved through dilution and soaking. The diluted solution can be reused, reducing usage costs. Simultaneously, it can inhibit bacterial growth during the storage of fresh walnut kernels, delay oxidative deterioration, maintain their good appearance and quality, extend shelf life, and meet the market demand for high-quality fresh walnut kernels.

The utility model discloses a line board processing zinc spraying room with ventilation mechanism, including zinc spraying room, still include air intake mechanism, the air intake mechanism sets up on the outer wall of zinc spraying room bottom, the air intake mechanism includes air intake and air supply machine, zinc spraying gun, the zinc spraying gun is installed in the slider below zinc spraying room top crossbeam, follow -up ventilation mechanism, the follow -up ventilation mechanism sets up in the one side of slider, and the follow -up ventilation mechanism includes clamping seat, ventilation suction pipe, telescopic branch pipe and dust cover, dust removal fan, the dust removal fan is installed in the zinc spraying room top chamber inside of zinc spraying room top end, and the output of dust removal fan is equipped with air supply inclined pipe, spray settlement mechanism, the spray settlement mechanism is installed in the zinc spraying room top chamber top above air supply inclined pipe. The utility model not only adopts follow -up ventilation mechanism and captures zinc powder in time, prevents the diffusion to worker breathing area, and through the settlement treatment to zinc powder, reduced the harm that zinc powder directly discharged caused.

The utility model relates to a kind of closed liquid adding device, it includes: it includes: sealed bucket, its lower part is provided with faucet, its top is detachably provided with bucket cover;Pad is set on the bottom of the sealed bucket, and let slot is set on it;Flexible liquid storage bag is fixedly set on the pad by magic tape component, the upper portion of the liquid storage bag is provided with transfer component for and raw material bucket detachably connected to carry out liquid filling, the bottom of the liquid storage bag is provided with liquid outlet pipe for and the faucet detachably connected, to discharge the liquid in liquid storage bag by the faucet, the liquid outlet pipe is placed in the let slot.Polyethylene plastic bucket pouring has reduced toxic gas overflow and diffusion, cause medical staff eye and respiratory mucosa exposure risk, guarantee the physical and mental health of medical staff.

This invention discloses the application of Uncaria rhynchophylla neutral polysaccharide URP-W in the preparation of anti-glioma drugs, belonging to the field of anti-tumor technology of medicinal plant polysaccharides. The invention obtains a crude polysaccharide extract from Uncaria rhynchophylla through hot water extraction and ethanol precipitation, followed by purification using a DEAE cellulose column and G200 dextran gel to obtain Uncaria rhynchophylla neutral polysaccharide URP-W. The monosaccharide composition of URP-W includes arabinose, rhamnose, galactose, glucose, xylose, mannose, galacturonic acid, and mannuronic acid in a molar ratio of 17.99:6.32:21.71:27.17:2.56:7.57:16.20:0.49. Experiments have shown that URP-W can inhibit the proliferation of gliomas and induce apoptosis, exhibiting significant anti-tumor activity against glioma cells, providing a new drug raw material and treatment method for the clinical treatment of gliomas.

The application belongs to the technical field of functional polypeptides, and particularly relates to an active peptide for senescent cells and a preparation method thereof, wherein the active peptide is obtained by molecular docking simulation screening and optimization with a helical structure segment in an IL-6R protein combined with a gp130 protein as a polypeptide template; the active peptide after functional optimization contains an FF unit driving nano self-assembly, a GFLG unit capable of being specifically cut by a lysosome protease highly expressed in a microenvironment of senescent cells, and an RYFQKWEKLRNQ unit generating high affinity with an IL-6 / IL-6R / gp130 complex; the designed active peptide itself has anti-aging activity and can also be used for synergistic delivery of drugs, and has a broad application prospect.

The invention provides application of periplocin in preparation of anti-PRRSV (Porcine Reproductive and Respiratory Syndrome Virus) drugs, and belongs to the technical field of antiviral drugs. Experimental results show that periplocin has extremely remarkable inhibiting and blocking effects on a 1-bit ribosome framing process of the PRRSV virus, and can be used for effectively inhibiting the replication of the PRRSV virus so as to inhibit the proliferation of the PRRSV virus; in addition, the compound has an extremely remarkable inhibition effect on the frame shift process of-1-bit ribosomes of different strains of PRRSV viruses; the periplocin can effectively inhibit replication and proliferation of PRRSV in vitro and in vivo of live pigs, can be used for preparing products for inhibiting proliferation of the PRRSV and can be used for preparing drugs for treating and preventing diseases caused by PRRSV infection, and the drugs are broad-spectrum anti-PRRSV drugs and have wide application prospects.

The present invention provides a high-protein bio-fermented aquatic feed and a preparation method thereof. The aquatic feed comprises the following raw materials in parts by weight: 20-30 parts of imported fish meal, 10-15 parts of compound minerals, 5-10 parts of bioactive peptides, 5-10 parts of lysine, 5-10 parts of compound trace elements, 3-8 parts of compound vitamins, 3-6 parts of herbal extracts, 2-5 parts of compound probiotics, 2-4 parts of immune polysaccharides, and 1-3 parts of compound enzymes; the herbal extracts are prepared by fermenting astragalus membranaceus, isatis root, liquorice root, calotropis gigantea, ventilago leiocarpa benth, clove, rhizoma chuanxiong, and galangal officinale. By organically integrating imported fish meal, astaxanthin-peptide chelate, herbal extracts, compound immune polysaccharides, compound probiotics and various nutrients, the present invention realizes the synergistic effect of "promoting feeding - enhancing digestion - strengthening liver and gall - enhancing immunity - resisting stress - inhibiting bacteria - stabilizing water quality", significantly improves the growth rate, survival rate and comprehensive breeding benefit of crustacean aquatic animals, and has good economic value and application prospect.

This invention discloses a probiotic liquid core ball cultured under polysaccharide confinement, its preparation method, and its application in improving children's intestinal flora. Belonging to the field of probiotic preparation technology, it employs an extrusion method combined with calcium alginate cross-linking technology, using xanthan gum and other thickening polysaccharides to optimize the types and concentrations of polysaccharides to construct the confinement space. The effects of different oxygen conditions on the encapsulation of different proportions of *Lactobacillus rhamnosus* LRa05 and *Bifidobacterium animalis* BLa80 were investigated to obtain the optimal probiotic liquid core ball cultured under polysaccharide confinement. This process is simple, uses safe raw materials, and after confinement culture, the viable bacteria count is ≥10⁹ CFU / g. It can directionally increase the abundance of beneficial bacteria in children's intestines, inhibit opportunistic pathogens, enhance flora diversity and stability, and is suitable for children's dietary scenarios, providing a safe and efficient intestinal flora regulation solution.

The utility model discloses dustproof graphite crusher, including crushing cavity, the top and bottom end of crushing cavity are provided with feed port and discharge port respectively, dust collection cavity, dust collection pump, the dust collection pump includes the air suction pipe and the air outlet pipe, and the dust collection mouth of air suction pipe is located the position of being close to feed port top, the air outlet pipe extends to the bottom of dust collection cavity, sealing plate subassembly, sealing plate subassembly is arranged in the inside of feed port and discharge port, sealing plate subassembly includes the sealing plate of symmetrical hinged setting in the inner wall of feed port, discharge port, be provided with the spring between sealing plate and the inner wall of the side, the end portion of mutual approach of sealing plate still is provided with the magnet of mutual suction. The utility model discloses through setting sealing plate subassembly in the inside of feed port and discharge port, through the synergies of spring and magnet, keep sealed state when no material passes, prevent dust from feed and discharge port and escape, when having material to pass, rely on gravity and open automatically, realize the dual function of sealing and discharging.

The utility model relates to welding equipment technical field, concretely relates to a kind of intelligent gantry submerged arc automatic welding machine, it includes: piece platform, top is equipped with multiple piece grooves along length direction, and both sides are equipped with machine tool track respectively;Welding machine tool, welding machine tool is transversely placed above piece platform, and two ends are respectively equipped with with machine tool track cooperation walking mechanism, welding machine tool top is respectively equipped with welding machine power supply corresponding each piece groove;Movable crossbeam, movable crossbeam is horizontally arranged in welding machine tool middle part, and movable crossbeam is equipped with with each piece groove corresponding cross slide;Telescopic arm, respectively with each cross slide corresponding each cross slide connection, bottom end is respectively equipped with welding torch, welding torch is connected with corresponding welding machine power supply;Controller, controller is set in one side of welding machine tool, and walking mechanism, telescopic arm, welding machine power supply and welding torch are respectively electrically connected with controller.The utility model is integrated, and automation design has significantly improved the efficiency and quality of I-shaped steel structure welding.

The present application relates to the field of pharmaceutical preparation and nanomedicine, and particularly relates to a kind of nano-drug composition, its combined drug delivery system and application.The nano-drug composition comprises alpha 1-AR blocker and amphiphilic nano-carrier;The alpha 1-AR blocker is loaded in the hydrophobic core formed by amphiphilic nano-carrier;The alpha 1-AR blocker is selected from one or more of prazosin, terazosin, doxazosin;The average particle size of the nano-drug composition is 220-260 nm, the polydispersity index is less than 0.3, and the encapsulation efficiency is greater than 50%.The nano-drug composition of the present application has dual functions of anti-tumor proliferation and immune microenvironment remodeling, improves the dispersion stability of the drug in physiological medium, effectively reduces the in vivo clearance rate, prolongs the circulation time, and realizes the efficient in vivo delivery of the drug.The preparation process of the nano-preparation is stable and can be produced on a large scale.

The invention provides application of a pharmaceutical composition in preparation of anti-influenza virus drugs, and belongs to the technical field of biological medicines. The invention provides a pharmaceutical composition of carabrone, panax japonicus saponin IVa and plantamajoside. Multi-target intervention is realized aiming at key stages (such as adsorption, replication and release) of an influenza virus life cycle. Experiments show that the composition can significantly inhibit replication and proliferation of influenza viruses. The natural component composition disclosed by the invention has the advantage of higher safety, provides a safer, effective and economic treatment choice for clinic, and has remarkable conversion value and market potential.