The continuously casting and head-less rolling process for moderately thick plate includes the following steps: continuously casting plate blank, depressing liquid core, high temperature rolling, end cutting with flying shear, steam water cooling, finish rolling, sectional shearing, laminated cooling, cold bed or ground winding, finishing and warehousing. The present invention has raised metal yield, lowered fuel and power consumption, low end cutting rate, less rolling gates, and high output and finished product rate.