Load-bearing composite panels, materials, and products made by surrounding with a long fiber and/or fiber cloth reinforced polyurethane resin, an assembly containing one or more load-bearing members, graphene, a structural polyurethane/resin sandwich composite and/or spider silk protein fiber-cloth-continuous fibers. The composite structures can provide stronger, lighter-weight structural items such as vehicle floor and body panels, bullet-proof anti-ballistic panel products, vehicle bullet-proof anti-ballistic body panel structures and floors, bullet-proof vests, vehicle chassis, monocoque chassis, motor homes chassis-bodies, fuselage floors and frames for aircraft and/or UAV's, bicycle and motorcycle frames, wind turbine blades frames and structures, ship or boat haul body structures, shipment containers, pre-fabricated walls of buildings, train structure body or floor panels, solar panel supports, battery housings, mobile home walls, roof modules, truck beds, and truck trailer floors. Such composite panels, materials, and products can also be utilized in artificial organs, ligaments or tendons, artificial disc vertebrae, ropes, and 3D printing parts.