180 results about "Artificial organ" patented technology

A network device that can be implanted in a subject is described. The device is configured to communicate over a computer network. In one embodiment, the device of the invention includes an internal interface in physiological communication with the subject. The internal interface is coupled with, and configured to send signals to, a processor. The processor is configured to receive and process the signals, and is further configured to communicate over a computer network with another such device. Such devices can be used to monitor and communicate information regarding a host's physiological status, monitor and / or control artificial organs and prosthetic devices, and / or dispense medication.

The invention provides articles of manufacture comprising biocompatible nanostructures comprising nanotubes and nanopores for, e.g., organ, tissue and / or cell growth, e.g., for bone, kidney or liver growth, and uses thereof, e.g., for in vitro testing, in vivo implants, including their use in making and using artificial organs, and related therapeutics. The invention provides lock-in nanostructures comprising a plurality of nanopores or nanotubes, wherein the nanopore or nanotube entrance has a smaller diameter or size than the rest (the interior) of the nanopore or nanotube. The invention also provides dual structured biomaterial comprising micro- or macro-pores and nanopores. The invention provides biomaterials having a surface comprising a plurality of enlarged diameter nanopores and / or nanotubes.

The invention is a series of soft lithographic methods for the microfabrication of biopoilymer scaffolds for use in tissue engineering and the development of artificial organs. The methods present a wide range of possibilities to construct two- and three-dimensional scaffolds with desired characteristics according to the final application. The methods utilize an elastomer mold which the biopolymer scaffold is cast. The methods allow for the rapid and inexpensive production of biopolymer scaffolds with limited specialized equipment and user expertise.

The invention provides articles of manufacture comprising biocompatible nanostructures comprising nanotubes and nanopores for, e.g., organ, tissue and / or cell growth, e.g., for bone, kidney or liver growth, and uses thereof, e.g., for in vitro testing, in vivo implants, including their use in making and using artificial organs, and related therapeutics. The invention provides lock-in nanostructures comprising a plurality of nanopores or nanotubes, wherein the nanopore or nanotube entrance has a smaller diameter or size than the rest (the interior) of the nanopore or nanotube. The invention also provides dual structured biomaterial comprising micro- or macro-pores and nanopores. The invention provides biomaterials having a surface comprising a plurality of enlarged diameter nanopores and / or nanotubes.

The present invention relates to a dermal substitute comprising the biodegradable polymer such as collagen and the biomaterial such as amnion, the preparation method and the use thereof. Specifically, the present invention provides with an amnion-collagen sponge complex structure prepared by attaching, inserting or incorporating an amnion obtained from placenta to / in collagen. Inventive dermal substitute can be applied to surgery and wound requiring skin graft, for example, severe burns such as second-degree burn, without rejection by immune system. Further, inventive dermal substitute with amnion instead of silicone membrane has several advantages, such as better biocompatibility, anti-inflammatory activity and promoting activity of wound healing and commercial utilization as basement membrane. Also, inventive complex structure can be used as the basic matrix of bio-artificial skin for culturing cells and the biodegradable basic matrix for preparing artificial organs.

A surgical simulator is disclosed herein. The surgical simulator includes an artificial organ and an enclosure substantially enclosing the artificial organ. The artificial organ is substantially formed of platinum cured room temperature vulcanization silicone rubber (“PCRTVS”).

The invention relates to a method for producing ceramic hollow fibers from nanoscale particles and to hollow fibers produced in such a manner. The inventive method is characterized in that the ceramic material has a solids content of >25% by volume, preferably >30% by volume and is processed by means of extrusion and spinning. The hollow fiber is sintered according to conventional sintering methods. A hollow fiber produced in this manner is used for metal, polymer and ceramic matrix reinforcements, for artificial organs, for microsystems technology components, for fiber optical waveguides, for ceramic membranes, for solid electrolyte in fuel cells (SOFC), for tissue engineering and for producing extremely light ceramic parts, such as heat shields or brake systems, that are subjected to temperature stresses. The inventive ceramic batch can also be processed by means of silk screening whereby resulting in the production of filigree structures over the ceramic silk screening.

The present invention relates to ultrafiltration. In particular, the present invention provides a compact ultrafiltration device and methods for generating an ultrafiltrate, both of which can be used for a variety of applications, including, but not limited to filtering blood, diagnostic applications, and as a bioreactor.

An artificial vessel scaffold is provided, of biocompatible materials and capable of being coated with selected cell types. A plurality of artificial organs are provided, formed of a biocompatible scaffold material and coated with selected cell types.

A bio-artificial organ system is provided comprising a wall surrounding a space which has a solid support for cell cultivation. The space includes a there dimensional matrix in the form of a highly porous sheet or mat and including a physiologically acceptable network of fibers or an open-pore foam structure; hydrophobic hollow fibers permeable to gaseous oxygen or gaseous carbon dioxide evenly distributed through the three dimensional matrix material and arranged in parallel running from one end of the matrix material to the other end of the matrix material. Cells obtained from organs are present in the extra fiber space for culture wherein the cells are provided with sufficient oxygenation and are maintained as small aggregates with three dimensional attachment.

According a charging system of this invention, an AC required for charging of an electric double layer capacitor of a storage device in the body may be transmitted from a feeding device outside the body through power receiving and power transmitting coils. The electric double layer capacitor may be charged in a contactless mode, without incising the body of the artificial organ user, while the storage device remains embedded in the body. The electric double layer capacitor may be charged reliably by avoiding a shortage of charging since the charge status of the electric double layer capacitor of the storage device is known during a charging operation.

The invention described herein provides systems and apparatuses for an initial preparation of an organ or tissue scaffold comprising an extracellular matrix, and subsequent recellularization of the scaffold to ultimately form a resultant artificial organ or tissue incorporating the natural and original extracellular matrix. The techniques and equipment of the invention collectively minimize scaffold collapse, compression or physical damage to the organ as well as afford the advantages of significant maintenance of the initial natural structural and biochemical attributes of the organ or tissue. The invention is particularly useful in organ and tissue transplantation and repair.

The invention provides a method for preparation of liquid core microcapsule with static sprayer: calcium chloride solution of 2-3 percent is mixed with thickening agent and then is uniformly mixed with core material substance; a certain amount of mixed solution is taken out and then is put into solution containing sodium alginate of 0.6-1.5 percent with static sprayer while adopting a flat needle for adhesive deposite or an injection needle as a nozzle; after capsulated, liquid core sodium alginate microcapsule is filtered and then is cleaned with purified water; then liquid core sodium alginate microcapsule is put into calcium chloride solution for continuous solidification of 5-10 minutes; then microcapsule is filtered and then is cleaned with purified water; at last microcapsule is stored in storage solution with calcium ion concentration of 0.05-0.01 percent. High viscosity malt dextrin or sodium carbonxymethyl cellulose or xanthan gum is adopted as thickening agent. Microcapsule prepared with the invention has liquid core, with uniform particle size, good sacculation performance, simple process and high membrane thickness, therefore, microcapsule has high mechanical strength and can be widely used in the field of pharmaceutical chemical engineering, artificial organ implantation and food processing, etc.

A drug-releasable medical device contains a controlled drug-release composition comprising 100 parts by weight of an organic polymeric material which is soluble in an organic solvent and insoluble in water, 5 to 60 parts by weight of a lipid-soluble, low molecular weight release auxiliary agent and 1 to 70 parts by weight of a drug. When the composition is applied on a stent, a catheter, an organ replacement medical device, an artificial organ or the like in the form of coating or the like, the medical device is provided with a drug release function. Argatroban or sarpogrelate hydrochloride or both of them are gradually released from the surface of a stent for treating coronary artery stenosis, for example. In order to exhibit a sustained-release function for a desired period of time, the drug to be gradually released is carried in a polymeric material coated on a surface of a metal forming the stent or in a porous stent substrate.

A technology that provides various modular biomimetic microfluidic modules emulating varieties of microvasculature in body. These microfluidic-base capillaries and lymphatic Technology modules are constructed as multilayered-microfluidic microchannels of various shapes, and aspect ratios using diverse biocompatible microfluidic polymers. Then, various semipermeable membranes are sandwiched in between these multilayered microfluidic microchannels. These membranes have different chemical, physical characteristics and MWCO values. Consequently, this design will produce much smaller dimension channels similar to human vasculature to achieve biomimetic properties like of human organs and tissues. By interchanging microfluidic-layers or the membranes various diverse modules are designed that act as building blocks for constructing various medical devices, various forms of dialysis devices including albumin and lipid dialysis, water purification, bioreactors, bio-artificial organ support systems. Connecting various modules in diverse combinations, permutations, in parallel and / or in series to ultimately design many unrelated medical devices such as dialysis, bioreactors and organ support devices.

The invention discloses an artificial blood vessel support, the artificial blood vessel is made from biological compatible materials, and can coat various selected cells. The invention also discloses various artificial organs made from biological compatible support material.

A bionic construction method of artificial organics includes: reconstructing a three-dimensional computer model of macroscopic appearance of an artificial organ, preparing a resin model close to a natural organ in shape by means of the 3D (three-dimensional) printing technique, sputtering a metal film to the surface of the resin model, depositing a micro-nano fiber structure layer, removing the resin model to obtain an artificial organ film, importing the three-dimensional computer model into a computer for materialization, designing a bionic vessel micro-channel structure, building a layered structure model, preparing bionic extracellular matrix of the artificial organic by means of the 3D printing technique, wrapping the bionic extracellular matrix with the artificial organ film, and sewing the contact edges of the two layers of the artificial organ film to obtain the artificial organ. The method is applicable to construction of the multi-scale multi-layer vessel structured artificial organic having bionic appearance and complex structure and used for cell growth.

A method is disclosed for cryopreserving living animal cells in immunoisolation membranes, including: (1) cutting out a living organ from an animal, (2) digesting the cutout organ into the discrete living animal cells and separating the discrete cells, (3) suspending the separated cells in a solution of sodium chloride containing sodium alginate and collagen, (4) forming microcapsules of the living animal cells by using the resulting suspension, (5) forming immunoisolation membranes around outer surfaces of the microcapsules of the living animal cells by covering the outer surfaces with alginate-(poly-L-lysine) and thereby obtaining the living animal cells enclosed in the immunoisolation membranes, (6) suspending the resulting living animal cells enclosed in the immunocapsules in a cell damage-preventing solution, and (7) immediately with liquid nitrogen.

The invention discloses an artificial organ used for in vivo implantation, which comprises an artificial organ matrix and an artificial organ surface modified layer, wherein the surface modified layer is a zinc oxide thin film the thickness of which is 10nm to 700nm, preferably a zinc oxide thin film the thickness of which is 200nm to 400nm. The zinc oxide thin film is doped preferably by light rare earth elements. The invention also discloses two methods for preparing the artificial organ the surface of which is modified by the zinc oxide coating, wherein in one method, a layer of pure or light rare earth-doped transparent zinc oxide thin film is prepared on the surface of the in vivo implanted artificial organ by adopting a radio frequency magnetic control sputtering technology to serve as a biological coating for improving an implant anticoagulant property; in the other method, the transparent zinc oxide thin film is deposited by adopting a method of magnetic filtration arc ion plating. The anticoagulant property and the mechanical property of the in vivo implanted artificial organ are improved.

The present invention is a method for manufacturing a phosphorylcholine group-containing polysaccharide wherein the aldehyde derivative-containing compound obtained by the oxidative ring-opening reaction of glycerophosphorylcholine is added to a polysaccharide containing amino groups as well as a new polysaccharide having phosphorylcholine groups obtained from this manufacturing method.The object of the present invention is to provide a phosphorylcholine group-containing polysaccharide that is superior in biocompatibility and moisture retention, and is useful as a polymer material for medical use, as well as a simple method of manufacturing it.The polysaccharide of the present invention is utilized, for example, in artificial organs, biomembranes, coating agents for medical tools, drug delivery, and in cosmetics.

Load-bearing composite panels, materials, and products made by surrounding with a long fiber and / or fiber cloth reinforced polyurethane resin, an assembly containing one or more load-bearing members, graphene, a structural polyurethane / resin sandwich composite and / or spider silk protein fiber-cloth-continuous fibers. The composite structures can provide stronger, lighter-weight structural items such as vehicle floor and body panels, bullet-proof anti-ballistic panel products, vehicle bullet-proof anti-ballistic body panel structures and floors, bullet-proof vests, vehicle chassis, monocoque chassis, motor homes chassis-bodies, fuselage floors and frames for aircraft and / or UAV's, bicycle and motorcycle frames, wind turbine blades frames and structures, ship or boat haul body structures, shipment containers, pre-fabricated walls of buildings, train structure body or floor panels, solar panel supports, battery housings, mobile home walls, roof modules, truck beds, and truck trailer floors. Such composite panels, materials, and products can also be utilized in artificial organs, ligaments or tendons, artificial disc vertebrae, ropes, and 3D printing parts.

The invention relates to a bioactive polysaccharide self-assembly finishing polyurethane material and a preparation method thereof. The bioactive polysaccharide self-assembly finishing polyurethane material is characterized by comprising a substrate and a finishing layer, wherein the substrate is made of a polyurethane material, and the finishing layer is prepared by finishing the surface of the substrate by using a layer-by-layer self-assembly technique; and the finishing layer contains electronegative lentinan sulfate and electropositive chitosan which are alternately self-assembled layer by layer on the surface of the substrate. The surface of the polyurethane material has favorable hydrophilicity, favorable function of resisting fibrinogen non-specific adsorption, high antibacterial activity for inhibiting Bcillus pyocyaneus and other bacteria, and favorable cell compatibility. In addition, the polyurethane material has the advantages of simple preparation technology, easy control, mild preparation conditions and low cost, and is especially suitable for preparing biomedical materials for artificial organs and devices with complicated shape and structure.

The invention relates to a method of cellulose blend fiber solvent and an application of the same, the method is: 1) evenly mixing the cellulose, the polyvinyl polymer and the ionic liquid, dissolved 1 to 80 hours in the 25-160[deg.] C, to form a uniform stability spinning dope of 3-40% of total solid content, the quality mixing ratio of the cellulose, the polyvinyl polymer and the ionic liquid is 99.5:0.5 to 60:40; 2) filtering and deaerating for 3-120 hours, the dope thread gushing from spinneret hole by coagulation bath is solidified to form primary cellulose; 3) drawing, washing, bleaching, finish application and drying to obtain the cellulose blend fiber. The invention prepares a blend cellulose fiber by ionic liquid, the method is high efficiency, green and environmental protection, the prepared fiber has satisfactory mechanical behaviors, and that underwear and handkerchief can be made by blend fiber, the spinning may be pure or blended into all kinds of clothing material, and also into the membrane for artificial organs, water processor, etc.

A pouch for forming an implantable artificial organ, including a closed shell provided in a semi-pervious membrane. The pouch further includes a sheet contained within the shell, the sheet including projections on the surface thereof for maintaining a space for cells between the sheet and the shell.

Disclosed is a cell sheet for tissue repair and bio-artificial tissue engineering. The cell sheet comprises treated stem cell embedded in its self-secreted extracellular matrix (ECM) and formed a cell sheet. The cell sheet is formed by isolating the stem cell, expanding the stem cell and treating the stem cell with biological factors or factors leading to the production of biological factors, to induce its differentiation, production of extracellular matrix and formation of a cell sheet in vitro. The cell sheet is used as a bioactive material or as an acellular material for the promotion of tissue repairs or used to form a bio-artificial organ for tissue replacement. The cell sheet of the present invention eliminates the need to use scaffolds for cell delivery. The cell sheet facilitates in vivo cell transplantation and provides some tensile mechanical strength for bearing early mechanical load during tissue repair.

The invention discloses artificial cornea and a manufacturing method thereof and relates to the technical field of artificial organs. The artificial cornea is manufactured based on 3D (three dimensional) printing technology. The manufacturing method includes setting up a human vision model; setting up a personal eyeball model by 3D scanning; importing data into a 3D printer; preparing printing materials; scanning the printing materials point by point through ultraviolet laser beams with wave length in 355 nm and beam quality M2 in 1.0-1.3, curing the liquid-state printing materials from point to line and line to surface, controlling a lifting platform to move by a computer, curing the liquid-state printing materials layer by layer, and finally stacking layer by layer to obtain a 3D-printed cured product; freezing and forming and successively processing. The manufacturing method is quick and accurate, simple and feasible to operate, low in cost, and capable of accurately controlling the microstructure of the materials. The artificial cornea is perfectly matched with an original optometric system of a patient, and the requirements of different patients for individual diopter can be met.

A tissue-engineered artificial skin able to regulate the pigment secretion is configured through externally culturing the ceratin cells, fibroblasts and melanocyte of skin, proportionally mixing by tissue engineering method, and forming artificial skin.