23results about How to "Good restorative" patented technology

The invention discloses a preparation method and application of athlete-derived bifidobacterium probiotics for intestinal barrier repair, and relates to the technical field of biochemistry and microorganisms, and the preparation method comprises the steps of special bacteria source sampling, directional separation and purification, molecular biological identification, antibiotic sensitivity evaluation and injury repair verification. According to the preparation method and application of the sportsman-derived bifidobacterium probiotics for repairing the intestinal barrier, the sportsman intestinal flora is used as an exclusive bacterial source, and the unique metabolic elite attribute and stress adaptability of the sportsman intestinal flora are utilized to directionally screen and obtain a bifidobacterium strain adaptive to an extreme physiological stress environment; the bottleneck that conventional probiotics are only suitable for a common physiological environment and the survival rate and activity in a stress state are greatly reduced is broken through, high survival rate and metabolic activity can be kept in extreme environments such as exercise heat stress and the like, and accurate repair of intestinal barriers is realized through multiple mechanisms; meanwhile, an exclusive screening, identification and safety evaluation system is established, so that the safety and functional specificity of the strain are ensured.

This invention discloses a near-infrared responsive self-healing coating and its preparation method, relating to the field of functional coating technology. The near-infrared responsive self-healing coating, by weight, comprises the following components: 100 parts of matrix resin, 1-3 parts of near-infrared absorber, 10-20 parts of self-healing agent, 8-15 parts of curing agent, 1-3 parts of dispersant, 0.5-2 parts of defoamer, and 20-30 parts of solvent. This invention utilizes a specific structured organic molecular near-infrared absorber, which exhibits good compatibility with the matrix resin and achieves uniform dispersion at the molecular level. This avoids the problem of easy agglomeration in traditional inorganic photothermal materials, while significantly improving photothermal conversion efficiency and solving the deficiency of insufficient photothermal conversion capability of conventional organic dyes.

The invention relates to the technical field of raw materials of skin care products, and particularly discloses an acne-removing composition as well as a preparation method and application thereof. The acne-removing composition comprises the following components in parts by mass: 1.32-4.6 parts of a composite extract; 0.01 to 0.02 part of a skin repairing agent; 10 to 20 parts of a humectant; 75.38 to 88.67 parts of a solvent; the composite extract is prepared by compounding codium tomentosum extract, cryptomeria fortunei bud extract, nymphaea tetragona flower extract, reed extract and ganoderma sinensis extract. The acne-removing mask has the advantages that the acne-removing effect is more thorough, and acnes are not easy to relapse.

This invention discloses a large-scale grass seeding device for grassland ecological restoration, belonging to the field of grassland ecological restoration technology. The device includes a seeding frame with two rows of plow blades mounted on its lower surface, the blades being staggered in position. Each plow blade has a cutting section at its front end, which is triangular in shape, and a supporting section at its rear end, which has a symmetrical butterfly-wing structure. The cutting section cuts linear planting grooves into the soil. A connecting rod is rotatably connected to the rear end of the seeding frame via a bearing, and a pressing roller is rotatably connected to the end of the connecting rod. This invention employs a triangular cutting section for linear grooving, only subjecting the soil to narrow-slit, linear, and minimal disturbance. The working surface is narrow and the depth is controllable, without damaging the original structure of the grassland surface. It can completely preserve the crust layer and litter layer, maximizing the soil's water retention, soil stabilization, and wind erosion resistance, thus preventing secondary degradation of the grassland ecosystem from the source and truly achieving protective ecological restoration.

This invention relates to recombinant mussel adhesive proteins, the nucleic acid molecules encoding them, nucleic acid constructs, expression vectors, recombinant engineered strains, pharmaceutical compositions, preparation methods, purification methods, and applications. This invention assembles and splices partial functional sequences from different mussels and type III collagen to obtain several novel mussel adhesive protein sequences. Further screening yielded recombinant mussel adhesive proteins Mfp5, Mfp55, Mfp131, and Mfp151, suitable for large-scale industrial production and exhibiting high expression levels. Efficacy experiments demonstrated that these proteins significantly promote cell migration, indicating their excellent cell repair function and broad application prospects.

The application discloses a kind of hydrogel microneedle patches based on bletilla striata polysaccharide composite engineered exosome and its preparation method and application, belong to the technical field of biomedical materials, with bletilla striata polysaccharide and methacrylated hyaluronic acid as matrix, and the hydrogel microneedle with excellent mechanical properties is prepared.The natural polyphenol caffeic acid is used to modify the bone marrow mesenchymal stem cell exosome, and the engineered exosome is loaded on the microneedle tip by centrifugation.The strong antioxidant capacity of caffeic acid is used to protect the structure of exosome, and a synergistic system is formed, combined with the antibacterial and anti-inflammatory properties of the bletilla striata polysaccharide matrix itself, the diabetic wound microenvironment can be improved from multiple dimensions such as bacteriostasis, antioxidant, anti-inflammatory and pro-angiogenesis.The preparation process of the application is simple and controllable, the product has high biological safety, and the active ingredients can be delivered precisely and minimally invasively, providing an efficient and safe solution for diabetic chronic wound repair.

The invention relates to the technical field of nursing materials, and discloses eye washing liquid for relieving eye fatigue and a preparation method thereof.The eye washing liquid is prepared from trehalose, taurine, sodium gualenate, sodium hyaluronate, ergothioneine, vitamin B12, vitamin B6, xanthophyll, mint, a humectant, a bacteriostatic agent, a chelating agent, a pH regulator and deionized water. Through the synergistic effect of the first synergistic composition and the second synergistic composition, retina cell injury induced by blue light can be effectively repaired, the repairing effect is superior to that of simple addition of a single component, blue light oxidative injury is repaired through a multi-target synergistic mechanism, a three-layer structure of a tear film lipid layer, a water layer and a mucoprotein layer can be reconstructed, and the repairing effect is good. According to the present invention, the tearable film stability is significantly improved, the excellent protection and repair effect is provided, the compatibility of the components is good, the product stability is high, and the multiple effects of ocular surface cleaning, asthenopia relieving, conjunctival congestion reducing and blue light oxidation damage preventing are provided.

This invention relates to the field of soil remediation technology, specifically disclosing a method for promoting iron cycling and degrading soil organic matter based on the electron shuttle effect of natural humic acid. The humic acid extraction method includes mixing natural soil material with an alkaline solution, stirring, and centrifuging to obtain a supernatant; acidifying the supernatant to obtain a humic acid precipitate; redissolving the precipitate in KOH solution, followed by acidification and centrifugation for purification; and finally freeze-drying and grinding to obtain humic acid powder. The application method involves premixing contaminated soil with a solution prepared from the humic acid powder, a ferrous salt solution, and deionized water, then adding a persulfate oxidant to react and degrade organic pollutants in the soil. This invention utilizes naturally extracted humic acid, effectively overcoming the limitations of slow iron cycling and high oxidant consumption in traditional iron-based oxidation systems, resulting in high remediation efficiency and environmental friendliness.

The application discloses a poly(lipoic acid) based temperature-sensitive hydrogel with adhesion fault tolerance and a preparation method and application thereof, and can be obtained by mixing lipoic acid and royal jelly derivative sodium royal jelly acid and standing the mixed solution at 37 DEG C. In the mixing process, SRJA with amphiphilic characteristics forms micelles in water, LA is aggregated in the micelles and triggers in-situ ring-opening polymerization to form poly(lipoic acid) (polyLA). With the increase of the LA content, excessive polyLA is formed and overflowed from the micelles, and the SRJA micelles are linked through strong ionic hydrogen bonds to form a thermally responsive adhesive hydrogel PolyLA-SRJA. At a physiological temperature, the obtained PolyLA-SRJA hydrogel forms transient adhesion on various tissues, is benignly separated from the tissues after the temperature is lowered, has no any residue, and can be repeatedly used after peeling, namely, adhesion fault tolerance.

This invention discloses a method for maintaining the taphole position of a steelmaking converter. The method involves: after slag removal from the converter, using a slag-blocking ball trolley, inserting and packing slag-blocking balls into the taphole to form a temporary barrier; then spraying and repairing the large brick at the taphole to fill eroded pits, restoring the refractory material thickness and structural integrity, thus completing the maintenance of the steelmaking converter taphole position. This invention offers excellent repair results. After spraying, the vortex pits on the surface of the large brick at the taphole are essentially filled, and the refractory material thickness increases from 224mm to 450mm. After 20 heats of steel production, the refractory material thickness remains at 320mm. The repaired layer exhibits excellent erosion and corrosion resistance. It extends the taphole's lifespan, significantly improving production continuity and efficiency while ensuring furnace safety. The method is simple to operate and low-cost, requiring no furnace shutdown or complex process adjustments, and can be implemented using existing equipment, significantly reducing maintenance and time costs.

The invention discloses a human epidermal growth factor temperature-sensitive sustained-release gel as well as a preparation method and application thereof, and belongs to the technical field of biological pharmacy. The preparation method of the human epidermal growth factor temperature-sensitive sustained-release gel comprises the following steps: S1, adding poloxamer and a thickening agent into purified water, and uniformly mixing to form a gel matrix; s2, respectively preparing a human epidermal growth factor solution and a chitosan-sodium tripolyphosphate colloid, and adding the human epidermal growth factor solution into the chitosan-sodium tripolyphosphate colloid for adsorption to obtain the chitosan-sodium tripolyphosphate colloid loaded with the human epidermal growth factor; s3, adding the chitosan-sodium tripolyphosphate colloid loaded with the human epidermal growth factors, a humectant and a stabilizer into the gel matrix, and adjusting the pH value. The gel can realize stable loading and controllable slow release of the human epidermal growth factor, so that the administration frequency and repeated administration operation are reduced, and the gel has important application value in treatment of refractory wounds.

The application provides a method for image restoration based on a generative adversarial network, which is based on a U-Net and an attention mechanism, uses an improved U-Net to extract large-range and multi-scale feature information, uses an attention mechanism network to obtain global feature information, and through verification, the restoration algorithm has better restoration effect and has wide application value.

The invention belongs to the field of collagen extraction, and particularly relates to a preparation method of a high-stability I-type collagen solution for injection and an obtained product. The method is realized by the following steps: firstly, pretreating a type I collagen freeze-dried product; and sequentially adding a sodium hyaluronate mixed solution and a chitosan mixed solution 3, fully and uniformly mixing, and adding a disodium hydrogen phosphate buffer solution to obtain the I-type collagen solution for injection. The preparation method disclosed by the invention is simple and easy to operate, the prepared animal-derived I-type collagen solution for injection is relatively good in uniformity and stability, and the selected components are safe and relatively excellent in effectiveness. The type I collagen and the chitosan have good effects of promoting cell proliferation, migration and repair, and related repair products are sold on the market; the type I collagen and the sodium hyaluronate have a good moisturizing effect; the trehalose component has good moisturizing and anti-oxidation effects, and particularly, the trehalose has excellent characteristics of keeping cell viability and biomacromolecule activity; the mannitol component has a good effect of improving the osmotic pressure molar concentration of the solution, the osmotic pressure of the solution can be basically kept consistent with the osmotic pressure of body fluid in the solution, and side effects such as edema are not prone to occurring.

This invention belongs to the field of oil and gas drilling and cementing technology, and relates to a magnetic self-healing composite material for micro-gap cement sheath interface and its directional migration and repair method. The magnetic self-healing composite material is a core-shell structured composite magnetic microsphere, consisting of, from the inside out, a core, an intermediate transition layer covering the core surface, an outer shell covering the intermediate transition layer surface, and a biodegradable protective film covering the outer shell surface. The core is composed of magnetic particles, the intermediate transition layer is composed of a coupling agent, and the outer shell is composed of self-healing material. The magnetic self-healing composite material is incorporated into cement slurry. During cementing, a strongly magnetic device capable of axial movement is simultaneously placed inside the casing cavity. The magnetic field drives the magnetic self-healing composite material to migrate directionally towards the outer wall of the casing and preferentially accumulates at the casing-cement sheath interface, forming a self-accumulating layer. When micro-gap occurs at the interface and formation fluid flows through it, the magnetic self-healing composite material expands upon contact with the flowing fluid, automatically sealing the micro-gap and achieving online self-repair of the cement sheath interface. This invention uses active magnetic field control to precisely deliver magnetic self-healing composite materials to the weakest interface of the cementing process, fundamentally solving the problem of wellbore sealing integrity failure caused by micro-gap at the cementing interface, and significantly improving cementing quality and the long-term safe production life of oil and gas wells.

The application discloses a latent fingerprint identification method and device, comprising the following steps: inputting a latent fingerprint image into a trained generative adversarial network to obtain an enhanced latent fingerprint image; inputting the enhanced latent fingerprint image into a trained encoder for compression to obtain low-dimensional potential data; performing forward diffusion on the low-dimensional potential data, continuously adding Gaussian noise to the low-dimensional potential data to generate random noise, performing reverse diffusion on the random noise, and gradually restoring the random noise to the low-dimensional potential data; inputting the restored low-dimensional potential data into a trained decoder for decoding to obtain a repaired image; according to the characteristics of the fingerprint image, the diffusion model is improved, the fingerprint direction field constraint is added to solve the generation problem of irrelevant fingerprints, the fingerprint identification is facilitated, and the latent fingerprint image identification performance can be improved.

The invention belongs to the technical field of damage repair of geotechnical engineering, and discloses a method for repairing static load damaged loess through an MICP technology, and efficient repair of the static load damaged loess is achieved through the steps of strain culture, cementing liquid preparation, bacterial liquid and cementing liquid application, repair and maintenance and the like. The method comprises the following steps: selecting bacillus pasteurii, carrying out amplification culture to 1.2-1.8, preparing urea and calcium salt into a cementing solution with a concentration of 1.5-3.0 mol / L according to a ratio, firstly applying a bacterial solution, carrying out field planting, then applying the cementing solution, and finally maintaining for 7-28 days under the conditions that the temperature is 25-35 DEG C and the relative humidity is greater than or equal to 85%. Calcium carbonate is induced to deposit in situ through microbial metabolism, damaged cracks are filled, particles are cemented, the compressive strength of the repaired light-medium damaged loess is 8.7%-15.7% higher than that of undisturbed soil, the internal friction angle is increased to 36 degrees, and the disintegration time is prolonged to be 5 times that of untreated soil. The method adapts to the alkalescence characteristic of the loess, is environment-friendly, is simple and convenient to operate, can effectively recover the mechanical property and water stability of the damaged loess, and is suitable for repairing the damage caused by static load in the loess area.

The invention relates to a CO2 laser atomic-scale defect repairing method based on a densification effect, which is characterized in that microsecond CO2 laser is used for inducing a material to generate the densification effect for atomic-scale defects which are difficult to repair in a fused quartz element, so that thermally induced relaxation and rearrangement of an atomic network are promoted, and low-stress repairing of various defects is realized. The method comprises the following steps: carrying out multi-modal characterization on a to-be-repaired area to obtain the type and distribution information of an atomic-scale defect; based on finite element simulation, determining an optimization process window capable of triggering uniform densification and having thermal stress lower than material strength; laser scanning repair is carried out in a controllable atmosphere environment according to optimized parameters, and infrared thermal image online monitoring and feedback control are assisted; and the repairing effect is evaluated through multi-dimensional collaborative characterization and laser damage threshold testing. According to the method disclosed by the invention, the effective repair of atomic-scale processing induction defects, intrinsic ring cluster defects and polluting impurities is realized by utilizing the densification effect on the premise of not triggering large-range melting and mass migration, and the laser damage resistance threshold of the fused quartz element is greatly improved.

The application discloses a concrete crack secondary biological material self-repairing method and belongs to the technical field of microbial self-repairing; the method comprises the following steps: firstly, wetting the surface of a concrete crack with deionized water; secondly, brushing a microbial self-repairing slurry on the surface of the concrete crack under a negative pressure condition and standing; thirdly, exposing the concrete to the sea for 30-300 days to enable the surface of the concrete to adsorb marine organisms to form a biological adhesion layer; and the microbial self-repairing slurry is prepared by mixing and preparing a bacillus pasteurii bacterial liquid and a cementing liquid. The method provided by the application is used for brushing the microbial self-repairing slurry first and then exposing the concrete to the sea, which is helpful to effectively filling the surface layer pores of the concrete, thereby optimizing the surface layer pore structure and improving the durability of the concrete.

This invention relates to a three-dimensional porous bioactive scaffold, a vascularized bone organoid, its preparation method, and its applications, belonging to the field of tissue engineering technology. The bioactive scaffold includes a scaffold body, a Piezo1 channel agonist loaded on the scaffold body, and an Nrf2 agonist and / or Nrf2 expression vector loaded on the scaffold body; the scaffold body is a 3D-printed PMBG / β-TCP composite porous scaffold. The vascularized bone organoid uses the three-dimensional porous bioactive scaffold as a supporting framework and also includes cellular components, including co-cultured bone marrow mesenchymal stem cells and endothelial cells. Compared with existing technologies, this invention successfully constructs a novel vascularized bone organoid capable of targeting the Piezo1-Nrf2 signaling axis and possessing anti-endothelial aging and mechanical enhancement functions.

The application relates to the technical field of AR coating liquid, and discloses a functional AR coating combined liquid and a production method thereof.The functional AR coating combined liquid is composed of AR coating combination A liquid, AR coating combination B liquid and AR coating combination C liquid; the AR coating combination A liquid is made of the following raw materials: functional silica sol and diluent; the AR coating combination B liquid is made of the following raw materials: doped silica sol and diluent; and the AR coating combination C liquid is made of the following raw material: ammonia.In use, the AR coating combination A liquid is a primer, the AR coating combination B liquid is a topcoat, and the AR coating combination C liquid is used when coating is heated and annealed.The AR coating glass surface layer prepared by using the AR coating liquid prepared by the application has excellent hardness, wear resistance and scratch resistance, can be used in a desert with more wind and sand, can resist static electricity and effectively prevent dust accumulation caused by static adsorption, and has excellent antireflection and transmittance increasing effect.

The invention discloses a medical glucan skin repair dressing, which comprises Ectoine, beta-glucan, sodium hyaluronate, trehalose, sodium carboxymethyl cellulose and the like, and is a sterile liquid dressing without glycerol and traditional chemical preservatives. The dressing has appropriate viscosity, excellent film-forming property and flexibility, can quickly form a transparent, breathable and flexible protective film after being applied to a wound surface, can be used for nursing skin barrier injury, low sensitization and healing promotion of superficial wound surfaces, energy equipment postoperative wound surfaces and the like, and is convenient to use.