Polymeric nanofibers have been developed which are useful in a variety of medical and other applications, such as filtration devices, medical prostheses, scaffolds for tissue engineering, wound dressings, controlled drug delivery systems, cosmetic skin masks, and protective clothing. These can be formed of any of a variety of different polymers, both non-biodegradable or biodegradable, and derived from synthetic or natural sources.
The present invention discloses 1) the composition of fibrous articles and 2) methods for using these articles in medical applications.
The biodegradable fibrous articles, which are preferably formed by electrospinning polymer solution of biodegradable fiberizable material with or in conjunction with medicinal agents and bioactive materials, comprise a composite (or asymmetric composite) of nanofibers with actives.
Nanofibrous articles having specific medical uses include controlled drug delivery devices, glaucoma implants, tissue engineering, wound dressings, reinforcement grafts, corneal shields, and orbital blowout or sinus reconstructive materials.
The methods include controlled drug delivery of a medicinal agent and providing treatment for inflammation, infection, trauma, glaucoma, and degenerative diseases.
The drug delivery compositions and methods of this invention are directed towards improving the delivery of drugs to a target area of the body. These drug delivery compositions are nanofiber webs, mats, or whiskers which incorporate an active ingredient for delivery into a bodily fluid. The active ingredient is delivered in a controlled manner by placing the nanofiber web into the bodily fluid which allows the drug embedded in the nanofiber to be released in a controlled and longer lasting manner.