1198results about "Electro-spinning" patented technology

A nanofibrillar structure for cell culture and tissue engineering is disclosed. The nanofibrillar structure can be used in a variety of applications including methods for proliferating and/or differentiating cells and manufacturing a tissue. Also disclosed is an improved nanofiber comprising a lipid, lipophilic molecule, or chemically modified surface. The nanofibers can be used in a variety of applications including the formation of nanofibrillar structures for cell culture and tissue engineering.

Disclosed are improved polymer materials. Also disclosed are fine fiber materials that can be made from the improved polymeric materials in the form of microfiber and nanofiber structures. The microfiber and nanofiber structures can be used in a variety of useful applications including the formation of filter materials.

This invention provides a hybrid nano-filament composition for use as an electrochemical cell electrode. The composition comprises: (a) an aggregate of nanometer-scaled, electrically conductive filaments that are substantially interconnected, intersected, or percolated to form a porous, electrically conductive filament network comprising substantially interconnected pores, wherein the filaments have an elongate dimension and a first transverse dimension with the first transverse dimension being less than 500 nm (preferably less than 100 nm) and an aspect ratio of the elongate dimension to the first transverse dimension greater than 10; and (b) micron- or nanometer-scaled coating that is deposited on a surface of the filaments, wherein the coating comprises an anode active material capable of absorbing and desorbing lithium ions and the coating has a thickness less than 20 μm (preferably less than 1 μm). Also provided is a lithium ion battery comprising such an electrode as an anode. The battery exhibits an exceptionally high specific capacity, an excellent reversible capacity, and a long cycle life.

The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic solvents, direct additives, or harsh chemicals. The invention further provides for the use of these solutions in production of materials, e.g., fibers, films, foams, meshes, scaffolds and hydrogels.

Disclosed is a method of producing a hybrid nano-filament composition for use in a lithium battery electrode. The method comprises: (a) providing an aggregate of nanometer-scaled, electrically conductive filaments that are substantially interconnected, intersected, physically contacted, or chemically bonded to form a porous network of electrically conductive filaments, wherein the filaments comprise electro-spun nano-fibers that have a diameter less than 500 nm (preferably less than 100 nm); and (b) depositing micron- or nanometer-scaled coating onto a surface of the electro-spun nano-fibers, wherein the coating comprises an electro-active material capable of absorbing and desorbing lithium ions and the coating has a thickness less than 10 μm (preferably less than 1 μm). The same method can be followed to produce an anode or a cathode. The battery featuring an anode or cathode made with this method exhibits an exceptionally high specific capacity, an excellent reversible capacity, and a long cycle life.

Provided herein is an apparatus for printing cells which includes an electrospinning device and an inkjet printing device operatively associated therewith. Methods of making a biodegradable scaffold having cells seeded therein are also provided. Methods of forming microparticles containing one or more cells encapsulated by a substrate are also provided, as are methods of forming an array of said microparticles.

The invention is directed to compositions and methods for preparing electrospun matrices comprising at least one natural biological material component and at least one synthetic polymer material. The natural component makes the matrices highly biocompatible while the molecular weight polymer component can impart additional strength mechanical strength to the scaffold and/or improve ease of manufacture by increasing viscosity and spinning characteristics of the solution during electrospining.

A vascular prosthesis comprising a first layer having a predetermined first porosity and a second layer having a predetermined second porosity, wherein the first layer and the second layer are each made of first and second electrospun polymer fibers.

The instant invention provides electrospun fiber compositions comprising one or more polymers and one or more biologically active agents. In specific embodiments, the biologically active agents are nerve growth factors. In certain embodiments, the electrospun fiber compositions comprising one or more biologically active agents are on the surface of a film, or a tube. The tubes comprising the electrospun fiber compositions of the invention can be used, for example, as nerve guide conduits.

A method of preserving organisms in viable form, the method comprising: suspending organisms in a solution of electrospinnable polymer; drawing droplets of said solution through a spinneret; applying an electrostatic field to said droplets under electrospinning conditions; so as to form fibers having a diameter no greater than about 5 μm within which distinct organisms are encapsulated in viable form.

The present invention refers to a method of fabricating a membrane made of a nanostructured material and its use.

Calcium-phosphate nanofiber matrices comprising randomly dispersed crystalline calcium-phosphate nanofibers are provided. The nanofibers are synthesized using sol-gel methods combined with electrospinning. The nanofibers may be hollow, solid or may comprise a calcium-phosphate shell surrounding a polymer containing inner core to which biologically functional additives may be added. The nanofiber matrices may be used to culture bone and dental cells, and as implants to treat bone, dental or periodontal diseases and defects.

Actuators (artificial muscles) comprising twist-spun nanofiber yarn or twist-inserted polymer fibers generate torsional and/or tensile actuation when powered electrically, photonically, chemically, thermally, by absorption, or by other means. These artificial muscles utilize non-coiled or coiled yarns and can be either neat or comprising a guest. Devices comprising these artificial muscles are also described.

A porous nanozeolite material having a first dimension less than about 1 micron and a second dimension less than about 100 microns. The nanozeolite material comprises pores having an average diameter less than about 50 nm. A method of making microporous nanozeolites is provided. The method comprises the steps of providing an aqueous solution comprising at least one nanozeolite precursor material or zeolite particles, and electrospinning the aqueous solution onto a substrate to form an electrospun material. The electrospun material comprises microporous nanozeolites. A method of making mesoporous nanozeolites is also provided. The method comprises the step of providing an aqueous solution comprising a nanozeolite precursor material and at least one structure directing agent, and electrospinning the aqueous solution onto a substrate to form an electrospun mesoporous nanozeolite material. A gas sensor device is provided. The device comprises nanozeolite sensing material.

A method for producing a fiber membrane of nanofibers that have both smooth and porous surface features. The method includes materials processing using polymer mixes with solvents and melt polymers with additives. The method includes nanomaterial incorporation onto a fiber structure after formation of the fiber structure. The fiber structure can be a part of a nanoparticle carrier material, a nanoparticle disposal medium, a lighting medium, and a catalysis medium.

The invention provides a flexible air-permeable pressure sensor based on a friction nano-generator and a fabrication method thereof. The flexible air-permeable pressure sensor based on a friction nano-generator is characterized by comprising a flexible carbon nano-fiber thin film and a nano-fiber thin film installed thereon and obtained through electrostatic spinning; the flexible carbon nano-fiber thin film is obtained through carbonizing nano particles doped fiber thin film obtained through electrostatic spinning. The pressure sensor prepared by the invention can effectively monitor the change of external force and has high sensitivity; the air-permeable and flexible characteristics ensure the wearing comfort of human body; the pressure sensor has wide application space in the field of medical wearable detection of human body.

The invention relates to a preparation method and application of electrospinning nanofiber. The preparation method is as follows: synthetic and/or natural polymer materials are dissolved in a volatilesolvent under normal temperature and normal pressure, functional substances are added, and nanofibers are obtained by electrospinning; the functional substances comprise, but are not limited to an odor substance, an organic fluorescent compound, a pigment, a temperature sensitive luminescent and color changing material, a cell growth factor, a hemostatic substance, one or a plurality of nutrientsincluding hyaluronic acid, collagen, and the like which promote skin growth. The nanofiber made by electrospinning has the special effects of sterilization, aromatic odor, fluorescent luminescence, multiple colors, temperature sensitive luminescence and color-changing, promoting wound healing, promoting inhibition and interfering with body function, maintaining skin cell vitality and the like. The method can be used in air purification, automotive air purification, fresh air systems, medical, beauty care, and other nanofiber products.

Disclosed are improved polymer materials. Also disclosed are fine fiber materials that can be made from the improved polymeric materials in the form of microfiber and nanofiber structures. The microfiber and nanofiber structures can be used in a variety of useful applications including the formation of filter materials.

Disclosed are an artificial dura mater and manufacturing method thereof. The artificial dura mater includes electrospun layers prepared by electrostatic spinning, at least one of which is a hydrophobic electrospun layer. Further, above the hydrophobic electrospun layer, there can be at least one hydrophilic electrospun layer. A transition layer can be further included between the hydrophobic and the hydrophilic electrospun layers. Additionally, cytokines and/or medicines can be affixed to either or both of the hydrophobic and the hydrophilic electrospun layers, by way of bio-printing. The disclosed artificial dura mater shows good biocompatibility, enhances dural tissue regeneration, achieves excellent repairing effects, prevents adhesion, allows complete absorption, has good mechanical properties, ensures low infection rates, and can be loaded with therapeutic agents.

The invention discloses a method for enhancing an electrostatic spinning nanofiber membrane. The blending electrostatic spinning-hot rolling bonding net fixing technology which can effectively improve the strength of the electrostatic spinning nanofiber membrane is provided. The method for enhancing the electrostatic spinning nanofiber membrane is characterized in that interphase blending electrostatic spinning is conducted through multiple types of thermoplastic high polymers with the fusion point at least 20 DEG C lower than that of other components or low-fusion-point thermoplastic high polymers and non-thermoplastic high polymers, electrostatic spinning jet flows of the components are distributed frontwards and backwards in the moving direction of a receiving device, and fibers are distributed randomly in a staggered mode; after hot rolling is conducted on a blending electrostatic spinning fiber membrane, the blending electrostatic spinning fiber membrane is treated, the hot pressing temperature is slightly higher than the fusion starting temperature of the low-fusion-point thermoplastic high polymers, time ranges from 1min to 10min, the pressure ranges from 1MPa to 20MPa, after hot pressing is conducted, part of the low-fusion-point thermoplastic high polymers is fused, point adhesion is generated on the nanofiber intersection portions, and a hole is not blocked. The method for enhancing the electrostatic spinning nanofiber membrane has the advantages that the strength of the prepared enhanced electrostatic spinning nanofiber membrane is far higher than that of a common electrostatic spinning membrane and original good performance of the electrostatic spinning nanofiber membrane can be kept.

Polymeric nanofibers have been developed which are useful in a variety of medical and other applications, such as filtration devices, medical prostheses, scaffolds for tissue engineering, wound dressings, controlled drug delivery systems, cosmetic skin masks, and protective clothing. These can be formed of any of a variety of different polymers, both non-biodegradable or biodegradable, and derived from synthetic or natural sources.

The present invention discloses 1) the composition of fibrous articles and 2) methods for using these articles in medical applications.

The biodegradable fibrous articles, which are preferably formed by electrospinning polymer solution of biodegradable fiberizable material with or in conjunction with medicinal agents and bioactive materials, comprise a composite (or asymmetric composite) of nanofibers with actives.

Nanofibrous articles having specific medical uses include controlled drug delivery devices, glaucoma implants, tissue engineering, wound dressings, reinforcement grafts, corneal shields, and orbital blowout or sinus reconstructive materials.

The methods include controlled drug delivery of a medicinal agent and providing treatment for inflammation, infection, trauma, glaucoma, and degenerative diseases.

The drug delivery compositions and methods of this invention are directed towards improving the delivery of drugs to a target area of the body. These drug delivery compositions are nanofiber webs, mats, or whiskers which incorporate an active ingredient for delivery into a bodily fluid. The active ingredient is delivered in a controlled manner by placing the nanofiber web into the bodily fluid which allows the drug embedded in the nanofiber to be released in a controlled and longer lasting manner.

Provided herein are nanofibers and processes of preparing nanofibers. In some instances, the nanofibers are metal and/or ceramic nanofibers. In some embodiments, the nanofibers are high quality, high performance nanofibers, highly coherent nanofibers, highly continuous nanofibers, or the like. In some embodiments, the nanofibers have increased coherence, increased length, few voids and/or defects, and/or other advantageous characteristics. In some instances, the nanofibers are produced by electrospinning a fluid stock having a high loading of nanofiber precursor in the fluid stock. In some instances, the fluid stock comprises well mixed and/or uniformly distributed precursor in the fluid stock. In some instances, the fluid stock is converted into a nanofiber comprising few voids, few defects, long or tunable length, and the like.

Electrospun nanofibrils and methods of preparing the same are provided. The electrospun nanofibrils comprise at least one polypeptide. A polypeptide can be dissolved in a solution, and the solution can be electrospun into a nanofibril. The solution can be added to a syringe or syringe pump, and an electric field can be applied to electrospin the at least one polypeptide.

Described are drug delivery systems incorporating electrospun fibers that comprise and deliver physicochemically diverse drug compounds. Such fibers provide significant advantages in drug agent release, such as adaptability for solid dosage delivery to mucosal tissues. This is in addition to allowing for controlled drug release. Systems and methods for large-scale electrospinning productivity are described, including novel microarchitectures allowing for variable pharmacokinetics in drug release.

An indicator device for determining the efficacy of an antimicrobial treatment process. The indicator device includes an active agent encapsulated in an encapsulation component. The encapsulation components preferably takes the form of an electrospun nanofiber including a polymer.

A method of preparing antimicrobial-containing polymeric products is provided, the method involving electrospinning a dispersion comprising a dispersible polymer, a fiberizing polymer, and one or more antimicrobial agents. The electrospun material is heated to remove solvent and the fiberizing polymer, giving a nonwoven polymeric material having antimicrobial agent incorporated therein. The material can be in the form of, for example, a non-woven sheet, tube, or covering.

The invention relates to an efficient and low-resistance electrospun nanofiber air filter material and a batch preparation method. The filter material is of a sandwich structure formed by alternately arraying spun-bonded nonwovens and nanofibers; by the adoption of a pinfree type electrostatic spinning nozzle and by an electrostatic spinning and electrostatic spraying synchronous combination technology, a nanofiber/microsphere composite film is prepared; a revolving rotary drum is used as a receiving device, and the spun-bonded nonwoven is used as a receiving matrix, so that a nanofiber/nonwoven composite material is obtained; a layer of spun-bonded nonwoven covers the surface of the nanofiber/nonwoven composite material to form the sandwich structure with the spun-bonded nonwovens and the nanofibers which are alternately arrayed; the sandwich structure is bonded to obtain the efficient and low-resistance electrospun nanofiber air filter material. The preparation process is simple, and high in controllability and repetitiveness, and the prepared air filter material has the characteristics of high efficiency and low resistance, and is uniform in thickness and stable in filter performance; batch production of the nanofiber filter material can be realized; the efficient and low-resistance electrospun nanofiber air filter material has very good application prospect in the field of air filtering.

The present invention provides a lithium secondary battery and its fabrication method. More particularly, the present invention provides a lithium secondary battery comprising a super fine fibrous porous polymer separator film and its fabrication method, wherein the porous polymer separator film is fabricated by the following process: a) melting at least one polymer or dissolving at least one polymer with organic solvents to obtain at least one polymeric melt or at least one polymeric solution; b) adding the obtained polymeric melt or polymeric solution to barrels of an electrospinning machine; and c) discharging the polymeric melt or polymeric solution onto a substrate using a nozzle to form a porous separator film. The lithium secondary battery of the present invention has the advantages of better adhesion with electrodes, good mechanical strength, better performance at low and high temperatures, better compatibility with organic electrolyte solution of a lithium secondary battery.

Long rod shaped M13 viruses were used to fabricate one dimensional (1D) micro- and nanosized diameter fibers by mimic the spinning process of the silk spider. Liquid crystalline virus suspensions were extruded through the micrometer diameter capillary tubes in cross-linking solution (glutaraldehyde). Resulting fibers were tens of micrometers in diameter depending on the inner diameter of the capillary tip. AFM image verified that molecular long axis of the virus fibers were parallel to the fiber long axis. Although aqueous M13 virus suspension could not be spun by electrospinning, M13 viruses suspended in 1,1,1,3,3,3-hexafluoro-2-propanol were spun into fibers. After blending with highly water soluble polymer, polyvinyl 2-pyrolidone (PVP), M13 viruses was spun into continuous uniform virus blended PVP (virus-PVP) fibers. Resulting virus-PVP electrospun fibers showed intact infecting ability to bacterial hosts after suspending in the buffer solution.

The invention relates to a MXene-based flexible polyurethane fiber membrane strain sensor. The sensor is prepared from a flexible substrate and a conductive layer; the flexible substrate is TPU flexible fiber film, the thickness of the fiber film is 100-300 micrometer; the conductive layer is an Mxene conductive layer wrapping the surface of the flexible substrate, the thickness of the conductivelayer is 20-50 micrometer; and the two ends of a thin film are connected with wires. Accordingly, the strain sensitivity of the sensor is improved, and the strain sensing range of the sensor is widened.