583results about "Monocomponent protein artificial filament" patented technology

The invention is directed to compositions and methods for preparing electrospun matrices comprising at least one natural biological material component and at least one synthetic polymer material. The natural component makes the matrices highly biocompatible while the molecular weight polymer component can impart additional strength mechanical strength to the scaffold and / or improve ease of manufacture by increasing viscosity and spinning characteristics of the solution during electrospining.

The invention is directed to formation and use of electroprocessed collagen, including use as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may be implanted into a recipient. The electroprocessed collagen may also be combined with other molecules in order to deliver substances to the site of application or implantation of the electroprocessed collagen. The collagen or collagen / cell suspension is electrodeposited onto a substrate to form tissues and organs.

The invention is directed to formation and use of electroprocessed collagen, including use as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may be implanted into a recipient. The electroprocessed collagen may also be combined with other molecules in order to deliver substances to the site of application or implantation of the electroprocessed collagen. The collagen or collagen / cell suspension is electrodeposited onto a substrate to form tissues and organs.

A method of forming electrospun fiber mats from a plurality of different biodegradable polymeric fibers is provided, in which a plurality of up to six different biodegradable polymer solutions are electrospun together by a method comprising the steps of providing a plurality of up to six different biodegradable polymer solutions each containing at least one biologically or pharmaceutically active material and each in communication with a needle for electrospinning a biodegradable polymer fiber from the solution, and pumping each solution through its respective needle into an electric field under conditions effective to produce uncontrolled charged jet streams of the polymer solutions directed at a grounded rotating mandrel, thereby forming fiber threads of the biologically or pharmaceutically active compounds and polymers in the solutions that are deposited on the mandrel to form an electrospun non-woven fiber mat, wherein the needles are positioned for co-deposition of the fiber threads from the polymer solution streams together on the mandrel to form a fiber mat.

The present invention provides a protein polymer material and a method for preparing the protein polymer material involving applying an energy such as electrical energy or gravitational energy to a protein to cause the protein to assemble in a controlled arrangement. The protein used in this method may be any suitable fibrillar protein capable of self-assembling.

A functional fibre of regenerated ceratin is prepared through preparing ceratin solution from goat or sheep wool, camel or yak hair, feather, leather leftover, etc, adding one or more of metal oxide, organic metal compound, chitin, chitosan, cyclodextrin, polyether and polyacrylic acid, which have the antistatic, antibacterial, deodorizing, drying, heating lagging and hydroscopc functions, and spinning.

Rotary spinning processes, more particularly processes for making hydroxyl polymer-containing fibers using a rotary spinning die, hydroxyl polymer-containing fibers made by the processes and webs made with the hydroxyl polymer-containing fibers are provided.

This invention includes a method of producing a thin, oriented layer of polymer material. The material is preferably produced by the method of introducing a shearing flow to a free surface in a predominantly monomeric solution of the self-assembling polymer sub-units, and inducing polymerization or growth of the monomer while in this shearing flow. The system for forming the oriented layer of material provides relative movement between a delivery system and the substrate on or over which the material is deposited. The rate of flow of the material from the delivery system and the relative velocity between the deposition surface and the material as it is delivered to the surface are controlled to properly orient the material at the desired thickness. These rates can be adjusted to vary the properties of the film in a controlled manner. Preferred embodiments include either angular or linear relative movement between the delivery system and the substrate.

The present invention provides a process for producing a colored structured protein product with protein fibers that are substantially aligned and the resultant product. Specifically, the plant protein is combined with a colorant and extruded, forming a colored structured protein product with protein fibers that are substantially aligned and the resultant product.

The invention relates to strengthened toughened regenerated silk fibers and a preparation method thereof. The preparation method comprises the following steps of 1, degumming silkworm cocoons, and dissolving the degummed silkworm cocoons to obtain a regenerated silk fibroin aqueous solution, 2, blending a graphene oxide aqueous solution subjected to ultrasonic treatment and the regenerated silk fibroin aqueous solution according to a certain ratio, 3, adding metal-oxide hydrosol into the mixture according to a certain ratio, 4, adding a CaCl2 solution into the mixture obtained by the step 3 to adjust a calcium ion molar concentration to 0.15-0.3mol / L, and sequentially carrying out concentration, 5, carrying out dry spinning on the concentrated solution as a spinning liquid at a room temperature, and 6, after-treating the composite fibers by an ethanol-water solution. The preparation method has simple processes and utilizes the raw materials having wide sources. The treated composite fibers have good strength and good toughness and have breaking strength of 70-380MPa, breaking elongation of 20-150% and breaking energy of 30-100J / g.

The present invention belongs to the field of radiation resisting technology, and is especially one kind of nanometer wave absorbing fiber. The nanometer wave absorbing fiber consists of nanometer wave absorbing particle of 1-100 nm diameter of fine fiber of 30-2000 nm diameter in the weight ratio of 3-35 to 65-97. The nanometer wave absorbing fiber has wide wave absorbing range, powerful wave absorbing capacity, lasting wave absorbing effect and high flexibility. It has wave absorbing function, as well as antistatic, bacteriostasis, biochemical protection and other functions.

The invention relates to element-negative-ion-releasing sterilizing mite-preventing electromagnetic-wave-preventing fire-retarding nano-grade fabric used in vehicles. The invention belongs to the technical field of textile fiber fabric production of vehicle-use nano-grade decorative fabric with functions of refreshing and air-purifying. The fabric is a nano-grade functional healthy textile. The nano-grade fabric provided by the invention is produced form chitosan, which is a natural high polymer extracted from shells of shellfishes, crabs and shrimps; a natural antibiotic humectant SCJ-920; a high-efficiency mite-preventing antibacterial agent SCJ-998; nano-grade negative-ion powder SCJ-900; negative-ion far infrared healthcare slurry 700; a fire retarding finishing agent ATF; an aromatic finishing agent SCM; electromagnetic-wave-preventing ferrites Fe2O3, Fe3O4, and Fe; substances such as TiO2, Al2O3, and ZnO used for providing far infrared radiation; an Ag-embedded nano-TiO2 (AT) antibacterial agent; nano-grade selenium or organic selenium which is rare on earth; organic germanium, Chinese herbal medicines, essential oil, maifanite, tourmaline nano-grade powder and other materials. A mixture of the materials is added to cotton, linen, wool, silk, polyamide fiber, acrylic fiber, terylene or viscose fiber spinning liquid, and the nano-grade fabric is produced through weaving.

Filaments containing a filament-forming material and an additive, such as an ingestible active agent, nonwoven webs, and methods for making such filaments are provided.

The invention discloses a silk-fibroin-based antibacterial nanofiber and a preparation method thereof. The nanofiber comprises the following components in parts by weight: 40-98 parts of silk fibroin, 1-10 parts of titanium dioxide and 1-60 parts of chitosan. The preparation method comprises the following steps: degumming and drying silk to obtain fibroin, processing fibroin to prepare a regenerated silk fibroin film, dissolving silk fibroin, titanium dioxide and chitosan in a polar solvent according to a certain mass ratio to prepare a spinning solution with the mass concentration of 0.01-80%, and preparing the silk fibroin-based antibacterial nanofiber with the average diameter of 10-1000 nm in a room-temperature state by electrostatic spinning equipment. The silk fibroin-based antibacterial nanofiber newly developed by the invention has an antibacterial ratio of more than 95%, has the characteristics of good biocompatibility and excellent mechanical performance while having the characteristic of long antibacterial property, and is suitable for biomedical materials.

A polymer-micelle complex suitable for use as an aid to preparing fibers, particularly nanofibers, by electrospinning. The polymer-micelle complex may be designed to impart viscosity, surface tension and conductivity properties optimal for electrospinning. By incorporating the complex as a secondary ingredient, one may electrospin sparingly soluble or low molecular weight polymers. Moreover, the polymer-micelle complex can be used as a generic carrier for preparing fibers incorporating other desired materials, such as rigid or globular (hard-to-spin) polymers, enzymes, cells, viral particles and nanoparticles.

The invention provides a method for preparing spinning solutions by using ionic liquid for dissolving animal keratin. Raw materials comprise pig hair, goat hair, sheep wool, cony hair, yak hair and wool without spinning and utilization values. A series of phosphate ester ionic liquid or acetic acid ionic liquid are used for dissolving wool keratin. The method comprises the following steps: washing the raw materials with water, degreasing, drying, crushing, adding 1-17wt% of raw material powder to the ionic liquid according to a certain ratio, adding 1-10wt% of additive, and carrying out mechanical stirring for 30-60 minutes at a temperature of 90-130 DEG C, thus obtaining the keratin spinning solutions with different concentrations. The preparation method has the advantages that the phosphate ester ionic liquid or the acetic acid ionic liquid is used as a solvent, the synthesis is simple, the dissolving process is easy to operate, the ionic liquid recycling is easy, the waste animal hair can be fully utilized, the raw materials are easy to obtain and low in cost, and the pollution of waste to environments can be reduced.

The invention is directed to compositions and methods for preparing electrospun matrices comprising at least one natural biological material component and at least one synthetic polymer material. The natural component makes the matrices highly biocompatible while the molecular weight polymer component can impart additional strength mechanical strength to the scaffold and / or improve ease of manufacture by increasing viscosity and spinning characteristics of the solution during electrospining.

The invention discloses a small-caliber silk fibroin tubular material and a preparation method thereof and belongs to the field of biomedical materials. The tubular material consists of three layers of materials which are firmly jointed, wherein an outer layer is a tubular electrostatic spinning silk net; a middle layer is a netlike pipe formed by weaving bright silk prepared from degummed silk; and an inner layer is a silk porous material. After the processes of soaking, drying, curing and the like in silk solution, the three layers of the material are firmly jointed, and the inner layer is treated by using anti-coagulation medicaments such as heparin and the like so that the material has coagulation resistance; and the tubular material obtained by using a forming die consisting of a cylindrical intermediate (1), a hollow cylinder (2) and a round base (3) has the inner diameter of between 1 and 8 millimeters, the thickness of between 0.2 and 2 millimeters, high mechanical property, biocompatibility, coagulation resistance and capability of repairing tissues such as blood vessels, nerves and the like.

A minimal injury resorbable stent comprising an oriented resorbable material drawn to a ratio about 7-350 is disclosed. The drawn materials of the present invention have tensile strength of about 50-500 MPa and Young's modulus of about 2-300 GPa. The bioresorbable stents can have cylindrical shape and optionally further comprise one or more of a solvent, plasticizer, biologically active agent and modifier. Also disclosed is a method for manufacturing a minimal injury resorbable stent. The process comprises contacting a resorbable polymer with a solvent to form a polymer mixture, extruding said polymer mixture to form an extrudate, drawing said extrudate to a draw ratio in the range of about 7-350 to form a drawn extrudate and forming said stent from said drawn extrudate. The process optionally further comprises coagulating the extrudate and annealing the extrudate and / or stent.

This invention includes a method of producing a nanostructured artificial template comprising more than one thin, oriented layer of polymer material. The material is preferably produced by the method of introducing a shearing flow to a free surface in a predominantly monomeric solution of the self-assembling polymer sub-units, and inducing polymerization or growth of the monomer while in this shearing flow. The system for forming the oriented layer of material provides relative movement between a delivery system and the substrate on or over which the material is deposited. The rate of flow of the material from the delivery system and the relative velocity between the deposition surface and the material as it is delivered to the surface are controlled to properly orient the material at the desired thickness. These rates can be adjusted to vary the properties of the film in a controlled manner. Preferred embodiments include either angular or linear relative movement between the delivery system and the substrate. The nanostructured artificial template is useful for inducing the production of a templated extracellular matrix by a population of cells.

The invention discloses a mesoporous silicon oxide particle / degradable polymer nano composite fiber, a preparation method and application thereof. The method comprises the following steps of: uniformly dispersing mesoporous silicon oxide particles into a solution of degradable polymers; and then preparing nano composite fibers by adopting an electrostatic spinning process, wherein the mesoporous silicon oxide particles are uniformly distributed in the degradable polymer fibers. Compared with traditional polymer fibers, the nano composite fiber can be used for better controlling the release ofdrugs and has quicker biodegradability and higher mechanical strength, and meanwhile, the fiber has better cellular compatibility. The nano composite fiber can be used as a tissue engineering support, a drug release vector, a wound coating material or a functional membrane.

Hydroxyl polymer-containing compositions, especially hydroxyl polymer-containing compositions that can be processed into polymeric structures, especially polymeric structures in the form of fibers are provided.

The invention provides a wool fibre fabric sweat shirt (pants) with functions of powerful antibiosis, cancer prevention and life prolonging by utilizing nano silver, selenium and germanium, belonging to the technical field of healthy wool textile fibre fabrics clothes production. In the real life of people, various germs, viruses and fungi are contacted unavoidably, in particular, various bird flu and HIV discovered currently seriously threaten the health of human beings. Nano silver can kill 650 types of pathogens; far-infrared rays are almost absorbed by the skin of human body completely to lead the surface temperature of the skin to rise; heat energy impels the blood vessel to expand, improves blood circulation and microcirculation; the electromagnetic wave is colorless, tasteless and formless, can easily cause pollution to human body and is a potential killer. The anions in the air are vitamins and longevity elements in the air and are beneficial to human body; selenium and germanium are important elements to prevent and resist cancer; and the mixture of bee series can comprehensively supplement a plurality of nutrient active components required by human body. After nano treatment, the efficacy of anti-aging traditional Chinese medicine can be improved to 100 times.

A method of forming a fiber made of peptide nanostructures is disclosed. The method comprises: providing peptide nanostructures in solution, and fiberizing the solution thereby forming at least one fiber of the peptide nanostructures. Also disclosed are methods of forming films and other articles using the peptide nanostructures.

A nanowire comprising only metal having an average length of 1 mum or more which could not be produced in the prior art, and a method of manufacturing this wire. This invention provides a method of manufacturing a metal nanowire, which comprises the step of reducing a nanofiber comprising a metal complex peptide lipid formed from the two-headed peptide lipid represented by the general formula (I): , in which Val is a valine residue, m is 1-3 and n is 6-18, and a metal ion, using 5-10 equivalents of a reducing agent relative to the two-headed peptide lipid. It further provides a metal nanowire having an average diameter of 10-20 nm and average length of 1 mum or more. It is preferred that the metal is copper.

The invention relates to a method for preparing natural material inorganic nanoparticle composite nano-fiber through electrostatic spinning, which comprises steps that a template is added into diluted aqueous alkali, the mixture is heated to 80-90 DEG C through an oil bath, mixed for 1-10 hours, gradually added with tetraethyl orthosilicate, centrifugally washed by deionized water and absolute ethyl alcohol sequentially, and dried and reflowed in HCL-ethanol mixed liquor to remove the template, so freeze dried mesoporous silicon is obtained; and natural materials are dissolved in the solvent to prepare the natural material solution, the mesoporous silicon is added into the natural material solution for electrostatic spinning, fumigating and crosslinking are carried out for 0-48 hours, so the natural material mesoporous silicon composite nano-fiber is obtained. The natural material inorganic nanoparticle composite nano-fiber which is prepared by the method has good biocompatibility, a simple preparation method and moderate reaction conditions, is low in experimental raw material price, has high drug-loading rate, can be controlled to be released for a long term, and can be applied in the biomedicine and tissue regeneration fields of growth factor and gene release of tissue engineering, cancer treatment and the like.

The invention relates to a method for preparing a natural material-liposome composite nanofiber based on electrostatic spinning technology. The method comprises the following steps of: (1) adding lecithin, cholesterol and octadecylamine into a reaction vessel, then adding anhydrous alcohol, stirring for dissolving, and finally depressurizing to remove alcohol so as to obtain a liposome membrane; (2) adding deionized water into the reaction vessel containing the liposome membrane, stirring at room temperature, and then carrying out ultrasonic treatment so as to obtain a liposome suspension with uniform particle sizes; (3) preparing a spinning solution containing natural materials by taking the liposome suspension as a solvent, and then carrying out electrostatic spinning so as to obtain a nanofiber; and (4) fumigating and cross-linking the nanofiber in a genipin solution or alcohol steam. The method provided by the invention has the advantages of simplicity in operation, low cost of raw materials, mild reaction conditions and good biocompatibility; and a composite nanofiber bracket prepared by the method provided by the invention can control the release of genes, growth factors and various medicaments, has stable performance, is easy to preserve, and has wide application prospects.

The present invention encompasses methodologies and parameters for the formation of nanofibrous (to microfibrous) laminin via electrospinning. The present application discloses conditions and appropriate parameters to synthesize laminin fibers from a diameter of about 10 nM to a diameter of over 1,000 nM via electrospinning.

The invention discloses a preparation method of fibroin / graphene conductive fiber. The preparation method comprises the following steps: mixing a graphene oxide solution and a fibroin solution, pouring a mixture into a polytetrafluoroethylene mould, drying to obtain a graphene oxide / fibroin compound membrane, putting the graphene oxide / fibroin compound membrane into a solvent, stirring till the graphene oxide / fibroin compound membrane is completely dissolved, performing ultrasonic treatment to obtain a spinning solution, putting the spinning solution into a container of electrostatic spinning equipment, performing high-voltage electric spinning to obtain composite fiber, and performing steam treatment to obtain the fibroin / graphene conductive fiber. The concentrations of fibroin and graphene in the fibroin / graphene conductive fiber prepared by the preparation method are high, so that the fibroin / graphene conductive fiber has good conductivity besides excellent wearability.