110 results about "Repairing tissues" patented technology

Non-woven graft materials for use in specialized surgical procedures such as neurosurgical procedures, methods for making the non-woven graft materials, and methods for repairing tissue such as neurological tissue using the non-woven graft materials are disclosed. More particularly, disclosed are non-woven graft materials including at least two distinct fiber compositions composed of different polymeric materials, methods for making the non-woven graft materials and methods for repairing tissue in an individual in need thereof using the non-woven graft materials.

Non-woven graft materials for use in specialized surgical procedures such as neurosurgical procedures, methods for making the non-woven graft materials, and methods for repairing tissue such as neurological tissue using the non-woven graft materials are disclosed. More particularly, disclosed are non-woven graft materials including at least two distinct fiber compositions composed of different polymeric materials, methods for making the non-woven graft materials and methods for repairing tissue in an individual in need thereof using the non-woven graft materials.

Non-woven graft materials for use in specialized surgical procedures such as neurosurgical procedures, methods for making the non-woven graft materials, and methods for repairing tissue such as neurological tissue using the non-woven graft materials are disclosed. More particularly, disclosed are non-woven graft materials including at least two distinct fiber compositions composed of different polymeric materials, methods for making the non-woven graft materials and methods for repairing tissue in an individual in need thereof using the non-woven graft materials.

Particles of non-woven graft materials for use in specialized surgical procedures such as soft tissue repair and wound management procedures, methods for making the powder, and methods for repairing tissue such as neurological tissue using the powder are disclosed. The particles can advantageously be used to fill irregular shaped areas or can be used in conjunction with non-woven graft materials.

Provided are tissue repair and sealing devices, and methods for the use of tissue repair and sealing devices, for use in both minimally invasive surgical (MIS) procedures and open, non-MIS procedures to rapidly repair tissue fenestrations and create a pressure-resistant, watertight seal in a tissue barrier. Tissue repair and sealing devices disclosed herein comprise an integrated graft and deployable clasp assembly and an applicator assembly having a graft-clasp lock cylinder that is slidably connected to a folded, deployable clasp. The applicator assembly places a graft on a tissue inner surface and a deployable clasp on a tissue outer surface to secure the graft to the tissue inner surface to, thereby, repair a tissue fenestration and create a watertight barrier.

The invention provides improved devices, systems, and methods for tissue approximation and repair at treatment sites. The invention provides devices, systems, and methods that may more successfully approximate and repair tissue by improving the capture of tissue into the devices. The invention may be a one-way mechanism that allows tissue to enter the mechanism but not easily exit, such as a leaf-spring, a protrusion, a pivoting arm and one or more frictional elements.

The invention relates to a tissue engineering articular cartilage simulating a four-layer structure of a natural cartilage and an in-situ 3D printing method of the tissue engineering articular cartilage, the structure and component characteristics of'surface layer-transitional layer-radiation layer-calcification layer 'of the natural cartilage are re-carved through precise layered modeling and layer-specific bio-ink, and the articular cartilage is obtained by means of an optimized in-situ 3D printing process. The tissue engineering cartilage which is matched with dissection of a defect area and consistent with mechanical and physiological functions of natural cartilage is directly constructed in an articular cavity. Besides, the in-vitro induced differentiation step of the BMSCs is reduced, the risk of cell mutation is reduced, meanwhile, the long-term integration of the repaired tissue and the host cartilage is improved, and the problem that the long-term effectiveness of clinical repair is insufficient is solved.

Particles of non-woven graft materials for use in specialized surgical procedures such as soft tissue repair and wound management procedures, methods for making the powder, and methods for repairing tissue such as neurological tissue using the powder are disclosed. The particles can advantageously be used to fill irregular shaped areas or can be used in conjunction with non-woven graft materials.

A suturing apparatus may include a shaft member having a lumen, and a first jaw member and a second jaw member that move between an open configuration and a closed configuration. A distal portion of the first jaw member may be pivotably connected to a distal portion of the second jaw member, and the distal portion of the second jaw member may have a distal opening. The suturing apparatus may further include a needle translates through the lumen of the shaft member and carries a suture, and a retention member in the distal opening of the second jaw member to remove the suture from the needle. The suture may be wrapped around the distal portion of the second jaw member. The suturing apparatus may be included in a suturing system having a suture. The suturing apparatus may be used in a method of repairing tissue.

A method of repairing tissue of a patient secures at least two sutures to two initial points of the patient, and couples sutures to a repair matrix comprising a scaffold portion and an expandable portion. The scaffold portion is configured to integrate over time with the tissue being repaired. The method also expands the expandable portion to urge the repair matrix against the tissue to produce a securing surface, and then secures the at least two sutures to two additional points of the patient. The at least two sutures traverse the securing surface of the repair matrix between the two initial points and the two additional points to secure the repair matrix to the patient.

Described herein are methods for repairing tissues (e.g., a meniscus, anterior cruciate ligament, rotator cuff, etc.) using collagen implants suitable. For example, the collagen implants are injected into a repair site to heal the tissue. Further described are collagen slurries, injectable collagen implants and methods of preparation thereof.

The invention discloses a bio-responsive high polymer material and application thereof, and belongs to the technical field of biomedical materials. The bio-responsive high-molecular material provided by the invention contains polymers shown as formulas i to viii. Wherein the polymers of the formulas i to viii have excellent fluorescence performance, aggregation-induced fluorescence enhancement performance, multicolor luminescence performance and biological response capability based on a redox reversible switch, and can be applied to sensing, counterfeiting prevention, metal ion detection, multicolor imaging of in-vivo and in-vitro cells and / or tissues and quantitative detection of in-vivo and in-vitro oxidized and / or reducing substances; active oxygen in in-vivo and in-vitro tissues and cells can be removed to achieve long-acting anti-inflammatory and anti-oxidation effects, and the compound can be used for treatment of oxidative stress related diseases and visual monitoring of the treatment process; the biological activity of enhancing tissue retention, stimulating collagen generation, repairing tissue and resisting oxidation and aging of the tissue is achieved, and the effect of filling and repairing in-vivo cells and tissue can be effectively improved; the compound also has the capability of being chelated with metal ions to form a high-molecular metal complex, and can be used for resisting tumors, resisting bacteria, filling and repairing tissues, promoting collagen generation and the like.

The invention relates to stimuli-responsive hydrogel for repairing tissue damage and a preparation method of the stimuli-responsive hydrogel, and the hydrogel is prepared from the following components in parts by weight: 6 to 8 parts of modified isocyano ethyl methacrylate, 2 to 4 parts of modified chitosan, 0.2 to 0.3 part of N, N '-methylene bisacrylamide, 0.1 to 0.2 part of ammonium persulfate and 3 to 5 parts of deionized water. The preparation method comprises the following steps: dissolving modified isocyano ethyl methacrylate and modified chitosan in deionized water, uniformly stirring to prepare a solution, adding N, N '-methylenebisacrylamide and ammonium persulfate, uniformly stirring by using a magnetic stirrer, transferring the mixed solution into a closed reaction container, introducing nitrogen for 10-15 minutes, putting the reaction container into a water bath at 60-80 DEG C, reacting for 30-60 minutes, filtering, washing, and drying to obtain the modified chitosan / isocyanatoethyl methacrylate copolymer. The stimuli-responsive hydrogel for tissue damage repair is obtained. The hydrogel disclosed by the invention has a multi-stimulation response controlled release mechanism and good dynamic network self-healing performance.

A suture assembly comprises a suture anchor, a repair suture, and a shuttle suture. Each suture has a looped end and a tail end. The tail end of the repair suture and the looped end of the shuttle suture extend out one side of the proximal end of the anchor, while the looped end of the repair suture and the tail end of the shuttle suture extend out the opposite side of the anchor. A method of repairing tissue includes implanting the suture anchor into a bone below and to one side of the tissue; passing the tail of the repair suture between a detached tissue and a bone, and then back over the detached tissue and through the loop of the repair suture to create a luggage tag construct before locking the tail of the repair suture against a portion of the suture anchor.

Particles of non-woven graft materials for use in specialized surgical procedures such as soft tissue repair and wound management procedures, methods for making the powder, and methods for repairing tissue such as neurological tissue using the powder are disclosed. The particles can advantageously be used to fill irregular shaped areas or can be used in conjunction with non-woven graft materials.

Compositions and methods for treatment of burns and other wounds. A unitary product containing all ingredients of the compositions may deliver composition ingredients to a surface of a burn / wound treatment site. The unitary product may include an ointment. The unitary product may include a cream. The unitary product may include a hydrogel. The compositions may include antibiotic ethacridine lactate. The compositions may include metal-containing species. The compositions may include a moisture-modulating agent. The compositions, when applied to the site, may constitute a barrier overlying the surface. The unitary product may deliver the antibiotic onto the surface. The unitary product may deliver the metal-containing species onto the surface. Each of the antibiotic and the metal-containing species may positively modulate wound bed and perilesional cellular processes supportive of healing. Initial testing and use studies have yielded good wound closures, with minimal-to-no scarring and high regain of function of repaired tissues.

Disclosed herein is a kit for manufacturing a scaffold for repairing tissue in a living being. The kit includes a structural reinforcing element. The structural reinforcing element is selected from i) at least one rod; or ii) a plurality of rods and brackets that are operative to be assembled into a cage. It comprises a plurality of module elements that can be assembled to form at least one module, where the module upon assembly contacts the structural reinforcing element. The module includes a plurality of curved ribs of different sizes that extend concentrically in a first direction when assembled. It also contains a spacing element that is operative to contact the plurality of curved ribs when assembled; where the spacing element extends in a second direction that is inclined at an angle to the first direction. The spacing element is operative to keep successive neighboring modules apart from one another.

The present invention discloses an inducer, macrophages, and their applications, relating to the interdisciplinary fields of immunology, cell biology, and regenerative medicine. The invention utilizes a composition composed of osteopontin (OPN) and other cytokines to culture and induce monocytes, thereby generating macrophages with strong repair functions. These macrophages can be used to repair tissue wounds, promoting the healing and tissue regeneration of chronic, difficult-to-heal wounds, and exhibiting excellent repair effects, making them suitable for widespread application.

Methods of repairing tissue include obtaining a suture including a first end defining an opening and a second end capable of passing through the opening; passing the first end through the tissue at a first location; passing the second end through the tissue at a second location; forming a luggage tag configuration by passing the second end through the first end; and securing the luggage tag configuration against the tissue. In some examples, the suture is a continuous closed loop, and in others the suture has a barbell configuration, with a linear central portion and a loop at each end. In still examples, the suture has a loop at one end and a tail at the other. The suture may be used without an anchor or may be part of a suture assembly including a suture anchor and, optionally, at least one other suture.

The invention discloses a macrophage hybrid scaffold as well as a construction method and application thereof, and belongs to the technical field of biological materials. The construction method comprises the following steps: extracting peripheral blood mononuclear cells, inducing the peripheral blood mononuclear cells into mature macrophages, loading the mature macrophages on a tissue engineering scaffold, and adding an immunoregulation factor to regulate the phenotype of the mature macrophages to obtain the M2 type macrophage hybrid scaffold. According to the invention, the macrophages with an immunoregulation effect are introduced into the tissue engineering scaffold, the macrophage hybrid scaffold is constructed together, and the macrophage hybrid scaffold can be used for repairing tissue defects, such as defect tissues such as skin, mucous membrane, viscera, cartilage or hard bone and the like; the macrophage hybrid scaffold can meet various requirements of providing mechanical support and bioremediation functions for tissue defect areas.

The invention belongs to the technical field of probiotic and amino acid compositions, and particularly relates to a compound probiotic composition as well as a preparation method and application thereof. The compound probiotic composition is prepared from the liposome, the compound probiotics, the compound amino acid, the vitamin and the complexing agent, the liposome serves as a carrier, the 12 probiotics, the compound amino acid and the vitamin serve as active ingredients, the complexing agent enables the active ingredients and the carrier to be fully fused and bonded, and therefore the compound probiotic composition is prepared by utilizing the carrier property and the fusion property of the liposome. And the wrapped active components can safely pass through the stomach and are absorbed by the intestinal tract, so that the effective components can be quickly absorbed and utilized. The compound probiotic composition prepared by the invention not only has the effects of protecting brain nerves, soothing nerves and promoting sleep, but also can effectively repair tissues such as amygdala kernel, hippocampus, hypothalamus and pineal body, nourish nerves and help to stabilize emotion.

Provided herein are bioresorbable, bioregenerative composite materials and compositions to regenerate tissues or organs to repair tissue or organ defects and constructs printed from the same as 3D structures shaped and sized to fill a tissue or organ defect. The composite materials are bioresorbable polymers, for example, polycaprolactone, and a bioresorbable graft material, for example, demineralized bone matrix. Also provided are methods for making the composite materials and compositions and methods for regenerating tissues or organs and repairing a tissue or organ defect using the constructs.

This invention belongs to the field of renal pathology testing technology and discloses a method for detecting type IV collagen expression in renal biopsy tissue, comprising the following steps: dewaxing and hydrating paraffin sections of renal biopsy tissue to obtain processed tissue sections; adding the processed tissue sections to a repair solution, heating to boiling, and then cooling to room temperature to obtain repaired tissue sections; adding protease to the repaired tissue sections for enzymatic digestion to obtain enzymatically digested tissue sections; adding a primary antibody to the enzymatically digested tissue sections for preliminary incubation, followed by adding a fluorescein-labeled secondary antibody against the primary antibody for further incubation. This method for detecting type IV collagen expression in renal biopsy tissue is applicable to cases where renal biopsy tissue lacks glomeruli or has too few glomeruli to detect type IV collagen expression. It has high specificity and can provide a new detection method for Alport syndrome in cases where renal biopsy tissue lacks glomeruli.

The present invention relates to an activated composition comprising cells which may be any cell type used for cell therapy, wherein the cells are activated by a chemotherapeutic agent. Further, an activated composition comprising a supernatant of the composition is provided, the supernatant comprising cells which may be any cell type used for cell therapy, wherein the cells are activated by a chemotherapeutic agent, and wherein the supernatant is used as a therapy. The present invention further provides a method for treating or preventing a disease or condition comprising using the activated composition.

Provided are tissue repair and sealing devices, and methods for the use of tissue repair and sealing devices, for use in both minimally invasive surgical (MIS) procedures and open, non-MIS procedures to rapidly repair tissue fenestrations and create a pressure-resistant, watertight seal in a tissue barrier. Tissue repair and sealing devices disclosed herein comprise an integrated graft and deployable clasp assembly and an applicator assembly having a clasp retain and release member that is slidably connected to a folded, deployable clasp. The applicator assembly places a graft on a tissue inner surface and a deployable clasp on a tissue outer surface to secure the graft to the tissue inner surface to, thereby, repair a tissue fenestration and create a watertight barrier.

The invention provides a polypeptide PN-VW22 and application thereof, and belongs to the technical field of polypeptide drugs. The polypeptide PN-VW22 provided by the invention is specifically as follows A1) or A2): A1) an amino acid sequence as shown in SEQ ID NO.1; a2) a fusion protein obtained by connecting a label to the N end or / and C end of A1). The polypeptide has obvious cell proliferation activity and anti-staphylococcus aureus bifunctional activity, and also has a wound repairing effect. The polypeptide is small in molecular weight and stable in structure, can be industrially produced through solid-phase chemical synthesis, can also be industrially applied to preparation of treatment medicines for promoting skin wound repair, and can be used as a candidate polypeptide medicine or a medical beauty product raw material for treating body surface wounds, repairing tissues, burns and skin ulcers, reducing scars and accelerating scar repair.

An implantable prosthesis for covering a defect in the peritoneum. The prosthesis may include a body (22) of implantable biocompatible material having a first surface (24) and a second surface (26). The first surface is tissue permeable and the second surface is adhesion resistant. The body includes a clip region adjacent an outer perimeter thereof having tissue clips (28) protruding in an outward direction away from the second surface. The prosthesis may be positioned between the peritoneum and a separate hernia repair fabric located in the anterior peritoneal pocket for repairing tissue or muscle wall defects, such as abdominal hernia.

The application relates to an antibody-coupled exosome and a preparation method and application thereof, and relates to the technical field of biotechnology. The antibody-coupled exosome comprises an anti-TIMP-1 antibody and an exosome, and the anti-TIMP-1 antibody is coupled to the surface of the exosome. The exosome is coupled to the surface of the exosome in a chemical coupling mode, the anti-TIMP-1 antibody is coupled to the surface of the exosome, the antibody-coupled exosome has the treatment functions of degrading collagen and repairing tissues, and the treatment effect of diseases is improved.

A knotless tensionable fixation system may be utilized for performing surgical methods for repairing tissue defects within a joint. An exemplary surgical method may include fixating a graft over top of the tissue defect with the knotless tensionable knotless fixation system. The knotless tensionable fixation system may include a plurality of knotless suture anchors, the graft, and a reinforcement construct. The reinforcement construct may establish a fixed segment of material over the graft after being secured in place by the plurality of knotless suture anchors.