160 results about "Repairing tissues" patented technology

Self-supporting, shaped, three-dimensional cross-linked proteinaceous biopolymeric materials that may be implanted in vivo, and methods of making such materials are disclosed. The biopolymeric materials most preferably include reinforcing media, such as biocompatible fibrous or particulate materials. In use, the preformed, shaped biopolymeric materials may be applied to tissue in need of repair and then sealed around its edges with a liquid bioadhesive. In such a manner, repaired tissue which is capable of withstanding physiological pressures may be provided.

An expandable support device for tissue repair is disclosed. The device can be used to repair hard or soft tissue, such as bone or vertebral discs. A method of repairing tissue is also disclosed. The device and method can be used to treat compression fractures. The compression fractures can be in the spine. The device can be deployed by compressing the device longitudinally resulting in radial expansion.

A suture anchor system for repairing torn or damaged tissue is provided and generally includes a first suture anchor having at least one length of suture attached thereto, and a second suture anchor having at least one length of suture attached thereto. Each length of suture is coupled to one another such that a distance between the first and second suture anchors with respect to each other can be selectively adjustable. The suture anchor system also preferably includes at least one slip knot that allows the first and second suture anchors to be maintained in a fixed position with respect to one another. In use, the suture anchors can be deployed through tissue to be repaired and into the anchoring tissue at a position spaced apart from one another by a selected distance. The suture length(s) can then be tensioned to re-approximate the torn or damaged tissue toward the anchoring tissue, thereby securely attached the torn tissue to the anchoring tissue.

The present system is directed to a method and system to stabilize and repair tissue. At least two opposing devices may be used to stabilize and repair the tissue, with the two devices cooperatively engaging the tissue interposed therebetween. Stabilization may be accomplished by opposing force, vacuum force, or mechanical devices disposed at the distal portion of one or both devices. After the tissue has been stabilized, fasteners may be deployed into the tissue. Fasteners include sutures, clips, and staples. Also disclosed is a minimally invasive method of accessing tissue located within a body and conducting a repair of the area using the system disclosed herein.

A biocompatible surgical fastener, comprising a sleeve and a screw or a pin, which expands when it is implanted in a patient. The sleeve is first implanted in a pre-drilled hole in the operating area of a patient, usually in a bone, cartilage or a bone and cartilage. When a screw or a pin is installed in the sleeve, the sleeve is caused to expand thereby stabilizing the fastener in the operating area. In many embodiments the screw or pin can be removed and reinserted without disturbing the tissue in the operating area. The surgical fastener can be used to repair tissue or to secure other implant devices in a patient.

Assemblies and methods suitable for knotless arthroscopic repair of tissue defects include two fixation members coupled by two limbs of suture comprising a continuous loop. A unidirectional restriction element that can be a preformed locking, sliding suture knot proximate to one of the fixation members, provides tensioning of the repair.

One or more tine plates for repairing tissue (e.g. hand / wrist tendons). Each plate has a center portion includes fenestrations, and / or a width or thickness that is less than that of first and second end portions of the plate, such that the center portion is more pliable than the first and second end portions. A first plurality of tines extends from the first end portion non-orthogonally and angled toward the center portion, and a second plurality of tines extends from the second end portion non-orthogonally and angled toward the center portion. A suture, button or ring are used to affix the plate(s) to the tendon, which the plate(s) extending across a sever point to serve as the load-bearing member, wherein the tines are positioned on both sides of the tendon sever point for fixating the tissue.

The present invention relates to a biocompatible, three-dimensional scaffold useful to grow cells and to regenerate or repair tissue in predetermined orientations. The scaffold is particularly useful for regeneration and repair of cardiac tissue. The scaffold contains layers of alternating A-strips and S-strips, wherein the A-strips within each layer are aligned parallel to each other and preferentially promote cellular attachment over attachment to the S-strips. Methods of producing and implanting the scaffold are also provided.

An antibacterial nano-class fibre material contains superfine high-molecular fibres (60-98 wt.%) and antibacterial agent (2-40 wt.%), and is prepared through dispersing or dissolving one or more high-molecular material in solvent to become transparent solution or mixture, dispersing the superfine particle of antibacterial agent (less than 20 microns) in said solution, and electric spinning. It can be used as protecting material, disinfecting filter material and tissue covering material for repairing tissue or promoting healing of tissue.

Devices for use in the regeneration or repair of body tissue (such as nerves) comprise a multi-lumen scaffold and, optionally, an outer sheath. The tissue guidance conduits are preferably formed of biocompatible, biodegradable charged polymer hydrogels, particularly charged oligo-(polyethylene glycol)fumarate hydrogels. The outer sheath is formed of a stronger material than the scaffold and preferably comprises a region at each end for suturing the device in place. Methods for making tissue guidance conduits and for repairing tissue are also described.

The present invention relates to medical devices for repairing tissue and more specifically to devices which facilitate tissue regeneration and to surgical methods for the implantation and fixation of such devices. In one embodiment, the medical device is an elongate conduit that includes a longitudinal bore extending therethrough to facilitate the transfer of blood from a vascular region of tissue to a tear or damaged area located in an avascular and / or semi-vascular region of tissue. A filament and / or filaments are attached to the conduit and are positioned to secure the conduit and fixate the adjacent tear walls in mutual engagement. In another embodiment, a series of conduits are connected via a filament and / or filaments to facilitate the implantation of multiple conduits.

Disclosed herein are improved osteogenic devices and methods of use thereof for repair of bone and cartilage defects. The devices and methods promote accelerated formation of repair tissue with enhanced stability using less osteogenic protein than devices in the art. Defects susceptible to repair with the instant invention include, but are not limited to: critical size defects, non-critical size defects, non-union fractures, fractures, osteochondral defects, subchondral defects, and defects resulting from degenerative diseases such as osteochondritis dessicans.

The present invention discloses a human body affinitive lubricating protective and repair gel, which combines photocatalyst (TiO2) particles with a disinfection material such as nano silver to produce a TiO2Ag compound, and mixes the compound with a filtered natural biological organism with a molecular weight below 50 Kbp and a concentration of 0.05˜5% including small molecules of collagen, chitin, chitosan, hyaluronic acid, vitamin C, and nano iron, and its pH value is adjusted to 6 which is close to the pH value of our skin, and thus the mixture constitutes a gel affinitive to human skins and non-toxic to human cells. An accessory ingredient such as an aromatic agent, a detergent, or a cosmetic agent is added in the manufacturing process to produce an emulsion or a paste for coating or spraying, which is used as a health or sanitation item such as a hand liquid soap, a cosmetic, a shampoo, or a disinfectant. The feature of the small diameter of the particles (1˜100 n / m) can penetrate the cuticle of our skin and remain at the derma inside the skin pores to produce a protective film, and the collagen can be absorbed by the skin to give the effects of repairing tissues, stopping bleeding, and lubricating skins. With the cyclic disinfection effect of the TiO2Ag compound, a deeper clean skin to prevent germs is obtained and a disinfection effect is achieved to eliminate acnes and pimples. The present invention also makes use of an oxidation-reduction mechanism of the photocatalyst (TiO2) to achieve long-hour disinfection and naturally remove germs.

The invention discloses a method for preparing a hydroxyapatite-natural macromolecular nano compound with a one-pot method. The method disclosed by the invention has the core characteristics that raw material powder is directly added, and mainly comprises the following steps: adding calcium salt and phosphate into a natural macromolecular solution according to the amount of substance ratio of Ca / P of 5 to 3; adjusting the pH of the system to 10 to 12 by using an alkali solution, wherein calcium ions, phosphate ions and hydroxyl ions in the system and natural macromolecules have an in-situ co-precipitation reaction; washing a reaction product to be neutral, and drying to obtain the hydroxyapatite-natural macromolecular nano compound; grinding and sieving to prepare nano composite particle products with different specifications. The method disclosed by the invention is simple and has moderate reaction conditions and small energy consumption; the obtained hydroxyapatite-natural macromolecular nano compound has good granularity, rigidity, microscopic appearance and crystallinity, and can be widely applied to the fields of bone defect repairing tissue engineering materials and medical equipment and the like of dental department, orthopedic surgery and the like.

A filament-guiding device directs a filament to spool over a rotating device within tissue. The filament-guiding device has both closed and open positions. In the closed position, the filament-guiding device is resiliently straightened for delivering into tissue. Within tissue, the filament-guiding device resumes a curved configuration in the open position to orient the filament perpendicular to the rotating device for spooling. The spooled filament is deployed by withdrawing the rotating device and filament-guiding device to bulk and repair the tissue.

A medical implant includes a metal composite that contains a cellular nanomatrix having a metallic nanomatrix material and a metal matrix disposed in the cellular nanomatrix, the medical implant being configured to disintegrate in response to contact with a fluid. A method for repairing tissue includes disposing an implant in a patient, the implant including a metal composite which contains: a cellular nanomatrix having a metallic nanomatrix material; and a metal matrix disposed in the cellular nanomatrix; contacting tissue of the patient with the implant, the tissue being in need of repair; and non-operatively removing the implant to repair the tissue.

The present invention is directed to the TVEMF-expansion of mammalian cord blood stem cells in a rotating TVEMF-bioreactor, to compositions resulting from the TVEMF-expanded cells, and to a method of treating disease or repairing tissue with the compositions. Various benefits and advantages to the compositions of the present invention are discussed herein.

Non-woven graft materials for use in specialized surgical procedures such as neurosurgical procedures, methods for making the non-woven graft materials, and methods for repairing tissue such as neurological tissue using the non-woven graft materials are disclosed. More particularly, disclosed are non-woven graft materials including at least two distinct fiber compositions composed of different polymeric materials, methods for making the non-woven graft materials and methods for repairing tissue in an individual in need thereof using the non-woven graft materials.

Suture passer devices and methods for repair tissue using them. In particular, described herein are suture passer devices having a tissue penetrating distal end that can be used to repair tissue such as the hip labrum. In general, such devices may be used to manipulate, including move or align tissues, and to suture them.

The present invention discloses biological surgical patch and its preparation process. The biological surgical patch includes one base material of animal membrane material, which is cross-linking fixed with non-aldehyde fixing agent and treated to eliminate antigen. The biological surgical patch made of natural biological material with collagen as main component may be degraded in the degradation speed synchronizing with the growth of the regenerating tissue, and the degraded products are amino acids or polypeptide capable of being absorbed by organism for the regenerative repair of the defected tissue. The present invention has no immunological rejection reaction, high biocompatibility, capacity of inducing tissue regeneration and good mechanical compliance, and can meet the requirement for repairing tissue.

The present invention is directed to the TVEMF-expansion of mammalian cord blood stem cells, preferably CD34+ / CD38− cells, to compositions resulting from the TVEMF-expanded cells, and to a method of treating disease or repairing tissue with the compositions. Various benefits and advantages to the compositions of the present invention are discussed herein.

A biocompatible tissue repair stimulating implant or “scaffold” device is used to repair tissue injuries, particularly injuries to ligaments, tendons, and nerves. Such implants are especially useful in methods that involve surgical procedures to repair injuries to ligament, tendon, and nerve tissue in the hand and foot. The repair procedures may be conducted with implants that contain a biological component that assists in healing or tissue repair.

The invention discloses a 3D printed Ti-PDA-PLGA microsphere bone defect repair stent. A 3D printed Ti stent is prepared by a laser sintering technology. Then, under certain conditions, dopamine is self-polymerized on the fiber surface of the 3D printed Ti stent to form a PDA coating, thereby preparing a 3D printed Ti-PDA stent; then PLGA microspheres carrying VEGF are prepared by a double emulsion-solvent evaporation method, and finally, BMP-2 and PLGA microspheres carrying VEGF are adsorbed and immobilized on the surface of the stent by an adsorption method, and finally the 3D printed Ti-PDA-PLGA microsphere bone defect repair stent is formed. The bone defect repair tissue engineering stent disclosed by the invention has the advantages of reliable mechanical property, high biological activity and safety, convenient implantation, small trauma and low cost, and can be used for the repair treatment of bone defect after bone traumas, bone tumors and bone infection.

Suture passers and methods of use. Described herein are suture passers preloaded with suture, including cartridges that couple to a suture passer to form a loaded suture passer that are configured to prevent a length of suture (e.g., already-passed suture) from re-entering the channel of the suture passer jaw and getting recaptured and / or entangled by the tissue penetrator. In particular, described herein are preloaded and automatically re-loading suture passers that are adapted to include a gate, guide, or shield on one of the jaws of the suture passer, and methods of operating such suture passers for surgical use including repairing tissue.

The invention relates to an anti-tumor medicine, which is prepared by Chinese medicine raw materials. The composition and the weight ratio of the Chinese medicine raw materials are codonopsis pilosula 30-100 parts, fructus ligustri lucidi 20-40 parts, orange peel 20-40 parts, chrysanthemum 30-50 parts, paris polyphylla 10-20 parts, dandelion 20-30 parts, patrinia 15-25 parts, snakeskin 15-25 parts, schizonepeta 30-45 parts, red flowers 15-25 parts, potentilla discolor 3-11 parts and fructus forsythiae 0.2-0.8 part. The anti-tumor medicine has a comprehensive formula, brings out the best in each other, strengthens the body resistance, cultures the basis, repairs tissue cells and enables the cells to be regenerated, reverses disease cells to be normal, can effectively treat malignant tumor including long cancer, esophagus cancer, intestinal cancer, bladder cancer, breast cancer, ovarian cancer, lymph cancer, uterine cancer and the like. The Chinese medicine is convenient to manufacture and use, safe, has no side and toxic effect, and is an ideal anti-tumor medicine.

The invention relates to a molybdenum disulfide nano-sheet in-situ modified biological ceramic stent, a preparation method and applications thereof, wherein the molybdenum disulfide nano-sheet in-situmodified biological ceramic stent comprises an akermanite bioactive ceramic stent and molybdenum disulfide nano-sheets growing on the surface of the akermanite bioactive ceramic stent in situ. According to the present invention, the molybdenum disulfide nano-sheet in-situ modified biological ceramic stent is expected to be used as the multifunctional implantation material for repairing tissue defects and treating tumors in clinical application.

The present invention provides materials and methods for repairing tissue and using vascular endothelial growth factor C (VEGF-C) genes and / or proteins. Methods and materials related to the use of VEGF-C for the reduction of edema and improvement of skin perfusion is provided. Also provided is are materials and methods for using VEGF-C before, during, and after reconstructive surgery.

A medical implant includes a metal composite that comprises a cellular nanomatrix comprising a metallic nanomatrix material and a metal matrix disposed in the cellular nanomatrix, the medical implant being configured to disintegrate in response to contact with a fluid. A method for repairing tissue includes disposing an implant in a patient, the implant comprising a metal composite which comprises: a cellular nanomatrix comprising a metallic nanomatrix material; and a metal matrix disposed in the cellular nanomatrix; contacting tissue of the patient with the implant, the tissue being in need of repair; and non-operatively removing the implant to repair the tissue.

The invention discloses an amino acid sequence of bone marrow mesenchymal stem cell affinity peptide, a screening method and an application and belongs to the field of bio-pharmaceuticals. The screening method comprises the following steps: utilizing a phage display process to respectively perform negative screening of human fibroblasts and positive screening of a bone marrow mesenchymal stem cell; after screening, extracting the bone marrow mesenchymal stem cell, and then decomposing the cell; extracting a phage segment which has specific affinity to the bone marrow mesenchymal stem cell; and sequencing the phage segment, thereby acquiring a peptide segment which has high affinity to the bone marrow mesenchymal stem cell. The amino acid sequence of bone marrow mesenchymal stem cell affinity peptide can be used for promoting the specific affinity of biological material to the bone marrow mesenchymal stem cell and has profound significance and wide application prospect in the field of repairing tissue engineered cartilages.