120 results about "Renal glomerulus" patented technology

This invention provides a compound of formula (I):or a crystalline form thereof, or a pharmaceutical composition thereof, or an oral pharmaceutical dosage form thereof; processes for the synthesis or manufacture of the compound of formula (I), or a crystalline form thereof, or a pharmaceutical composition thereof, or an oral pharmaceutical dosage form thereof; and the use of said compound, or a crystalline form thereof, or a pharmaceutical composition thereof, or an oral pharmaceutical dosage form thereof, for the treatment of patients suffering from or subject to diseases, disorders or conditions involving cell survival, proliferation, and migration, including cardiovascular disease (e.g., arteriosclerosis and vascular reobstruction), cancer, (e.g., AML and malignant glioma)glomerulosclerosis, fibrotic disease and inflammation.

The invention provides an in-vitro detection method of human cystatin C. The method adopts a magnetic particle separation chemiluminescence immunoassay technology which is a product integrating an enzyme labeling technology, a magnetic particle separation technology and a chemiluminescence detection technology and has the advantages of high sensitivity, good specificity, good repetitiveness, and the like. The method can be used for measuring the content of cystatin C in the serum, the plasma and the urine of a person, and the indexes are mainly used for clinically evaluating the renal function and mainly used for monitoring the filtration rate of glomerulus, the renal tubular dysfunction and various secondary nephropathies.

Disclosed is a Chinese medicament for treating acute glomerular nephritis wherein the recipe includes astragalus root 20g, root of red rooted saliva 15g, cogongrass rhizome 40g, rhizome smilacis glabrae 100g, motherwort 20g, malt 30g, arctium fruit 10g, bletilla tuber 12g, kudzuvine root 8g, cordate houttuynia 10g, plantain seeds, polyporus umbellatus each 20g, alkanna tinctoria, eclipta, notoginseng each 30g, Achyranthes bidentatae 25g, sweet basil, ledebouriella root each 30g. The Chinese medicament has simplified recipe, easy preparing process and low price.

The present invention relates to Chinese medicine for preventing and treating chronic renal lomerulus diseases, and is especially the medicine composition of one kind of compound Chinese medicine Tongmai oral liquid and its preparation process. The medicine composition is compounded with the effective parts of astragalus root, notoginseng, red sage and angelica, and contains compound polysaccharide and compound saponin in the ratio of 1-12. The medicine composition has the functions of benefiting Qi, promoting blood circulation, strengthening immunological stability, lowering the permeability of filtering membrane in renal lomerulus, improving microcirculation, etc., so that it can improve and stabilize kidney function.

The present invention relates to an inhibitor of matrix metalloprotease (MMP) production and tumor necrosis factor (TNF) production, and medicines for the treatment of diseases such as chronic rheumatoid arthritis, osteoarthritis, allergic diseases, psoriasis, transplant rejection, arterial sclerosis, ischemic re-perfusion disorder, diabetic nephritic and ocular diseases, cancer, autoimmune glomerulonephritis, infectious diseases, Crohn's disease, inflammatory intestinal diseases and autoimmune hepatitis, each comprising certain polyazanaphthalene compounds or pharmaceutically acceptable salts thereof as active ingredients.

The invention relates to an isolated multipotent glomerular mesenchymal stem cell derived from adult human kidney (hGL-MSC), which is characterised by the marker profile CD133−, CD146+, CD34− and CD105+. A method of preparing the hGL-MSC of the invention form decapsulated glomeruli is also disclosed, as well as the uses of the hGL-MSC of the invention in the regenerative treatment of the kidney, particularly for the treatment of injuries or diseases affecting renal glomeruli.

A Chinese medicine for treating child acute glomerulonephritis pertains to a Chinese medicine for treating nephritis. The components contain: 15g of heartleaf houttuynia herb, eclipta, motherwort and barbated skullcup herb respectively; 10g of plantain herb and 1.5g of common rush. The invention has the auxiliary prescriptions that for the patient with obvious blood urine, 10g of Japanese thistle herb and field thistle herb respectively, 10g of Indian madder root, 10g of Chinese arborvitae twig and leaf, 30g of hairyvein agrimonia herb and 30g of imperata rhizome are added; for the patient with swelling throat, 10g of figwort root, 15g of dyers woad root and 10g of burdock fruit are added. The dosage materials in the prescription are all made from natural traditional Chinese herbal medicines by the traditional processing method. The materials can be easily gotten; the prescription and the preparation method are simple; the expense for preparing the medicine is low. The compatibility of the traditional Chinese herbal medicines is simple; the medicines used in the medicine prescription are all natural herbal medicines which can be conveniently gotten and used; the manufacturing method is simple; the curative effect after being taken is good; the medicine price is cheap, and the medicine is especially fit for people who live at the remote small villages away from villages and towns to use. The treatment expense for the patient with the disease of the child acute glomerulonephritis is low, which solves the treatment problem, which is caused by low family income, poor living and lack of local medical treatment condition.

The invention discloses application of a Chinese medicinal composition in preparing a medicament for treating chronic glomerulonephritis. The Chinese medicinal composition consists of eight gouts of Chinese medicaments such as astragalus root, steatite, selfheal, and the like. The medicinal composition has the efficacies of promoting qi transformation, promoting diuresis and softening hardness to dissipate stagnation. The clinical research shows that the Chinese medicinal composition can effectively treat the chronic glomerulonephritis.

Uteroglobin has been discovered to prevent IgA mediated diseases, such as IgA nephropathy, by preventing the deposition of IgA-Fibronectin immunocomplexes in tissues such as the renal glomeruli. The invention therefore includes methods of treating such diseases by administering therapeutically effective amounts of uteroglobin (and variants or mimetics) to prevent or improve the IgA mediated condition. Transgenic uteroglobin knockout animals, and animals in which uteroglobin-protein expression is reduced by antisense technology, also provide systems for studying IgA mediated diseases, and screening for appropriate treatments.

The present invention provides a use of compounds from Antrodia camphorata in manufacturing medicaments for treating kidney diseases, wherein the compounds is represented by formula (I):wherein R1 is a hydrogen atom or acetyl group, R2 iswherein the kidney disease is glomerulosclerosis or glomerulonephritis.

The embodiment of the invention relates to the field of immunodiagnosis, in particular to a human alpha1-microglobulin (MG) determination kit with high sensitivity and a wide detection range. The human alpha1-MG determination kit provided by the embodiment of the invention comprises a reagent 1, a reagent 2 and human alpha1-MG calibration products of different gradient concentrations, wherein thereagent 2 comprises carboxylated latex microspheres labeled with a human alpha1-MG monoclonal antibody only and carboxylated latex microspheres labeled with a human alpha1-MG polyclonal antibody only;and the average particle size of the carboxylated latex microspheres labeled with the human alpha 1-MG monoclonal antibody only is larger than that of the carboxylated latex microspheres labeled withthe human alpha 1-MG polyclonal antibody. The human alpha1-MG determination kit provided by the invention can complete the detection of a single sample within 10 minutes with excellent precision, accuracy and anti-interference performance, can well reflect the renal tubular reabsorption function and glomerular filtration function, is very suitable for clinical biochemical analyzers, and greatly facilitates clinical examination.

The present invention relates to the novel use of certain piperidinyl-indole derivatives in the treatment of patients suffering from renal diseases or disorders, and in particular for the treatment ofpatients suffering from C3G (C3 glomerulopathy) and IgAN (IgA nephropathy).

The invention belongs to the field of Chinese medicines, and relates to a Chinese medicinal compound preparation for preventing and controlling chronic kidney disease and renal fibrosis and a preparation method thereof. On the basis of the theory of 'body resistance weakened while pathogenic factors prevailing, insufficiency of Qi and blood, and blood stasis and collaterals obstruction' in traditional Chinese medical science, the Chinese medicinal compound preparation is prepared from Chinese medicines such as Danshen root, angelica sinensis, peach kernel, twotooth achyranthes root and processed rhubarb. Through animal experiment and clinical trial, the Chinese medicinal compound preparation can improve renal haemodynamics, adjust lipid metabolic disturbance, enhance oxidation resistance, and inhibit over expression of cell factors so as to improve glomerulosclerosis and interstitial fibrosis degree, protect residual renal structures and functions, and delay the process of early-stage and medium-stage chronic renal failure deterioration. The Chinese medicinal compound preparation is particularly suitable for treating patients who suffer from chronic kidney disease (CKD2-4) and renal fibrosis which comprise renal insufficiency, proteinuria, atrophy of kidney and the like.

The invention relates to the technical field of microfluidics and provides a microfluidic chip and an application thereof. The microfluidic chip comprises an upper substrate, a lower substrate, a first porous membrane and a second porous membrane, wherein a first liquid inlet, a second liquid inlet, a first liquid outlet, a second liquid outlet, a first chamber, a second chamber and a first microchannel are arranged on the upper substrate; the second liquid inlet, the first chamber, the second chamber and the second liquid outlet are sequentially communicated through the first microchannel; the lower substrate is provided with a third liquid inlet, a third liquid outlet, a third chamber, a fourth chamber and a second microchannel, and the third liquid inlet, the third chamber, the fourth chamber and the third liquid outlet are sequentially communicated through a second microchannel. According to the microfluidic chip, the four chambers are formed, upper fluid and lower fluid can be subjected to material exchange twice on porous membranes separating the four chambers, so that the blood purification process of glomerular filtration and tubular secretion and reabsorption of renal units can be simulated with high simulation degree.

The invention relates to new medical applications of a natural monomer compound pterostilbene, in particular to applications of the pterostilbene in preparation of medicines for preventing and treating a chronic glomerular disease, and applications of pterostilbene in preparation of medicines for preventing and treating progressive chronic glomerular disease. Animal test results show that the pterostilbene has an obvious effect on prevention and improvement of a glomerular function and an organic injury of a fructose model rat renal. The pterostilbene is matched up with relevant adjuvants, a conventional preparation method can be utilized to obtain a health care product or a medicine aiming at preventing and treating the glomerular disease. The above health care product and the medicine can be used for the diseases relevant to the chronic glomerular lesion, such as diabetes and metabolic syndrome and the like, so that the glomerular progressive course in the relevant diseases can be delayed and improved.

The present invention relates to the field of nephrology. More specifically, the present invention provides methods and compositions useful for more precisely estimating glomerular filtration rate (GFR). In a specific embodiment, a method for calculating the estimated glomerular filtration rate (eGFR) in a patient comprises the steps of (a) measuring the level of one or more metabolites using mass spectrometry from a blood sample obtained from the patient; and (b) calculating the eGFR using an algorithm that utilizes the measured levels of the one or more metabolites.

The invention discloses a medicament composition and a preparation method for treating chronic glomerulonephritis. The medicament composition comprises the components of raw material medicament based on portions by weight: 450 to 550 portions of milk veteh, 200 to 300 portions of angelica, 330 to 430 portions of yam, 200 to 300 portions of bupleurum, 250 to 350 portions of pyrrosia lingua, 250 to 350 portions of umbellate pore furgus and 50 to 100 portions of leech. The medicament composition has obvious effect on treating chronic glomerulonephritis, raises high cutting and low cutting of whole blood viscosity, blood plasma and red cell accumulation, reduces the levels of the total protein and the albumin of blood, raises the levels of the nitrogen and the creatinine of blood urea, improves blood haemorheology and raises urinary output by 3h and total urinary output.

The invention discloses a detecting system for a glomerular filtration rate and relates to the technical field of medical treatment and public health. The detecting system comprises a patient information collecting terminal, a serum creatinine detecting terminal and a glomerular filtration rate detecting device, wherein the patient information collecting terminal is used for collecting the basic patient information from a patient database; the serum creatinine detecting terminal is used for detecting the serum creatinine level of a patient; the glomerular filtration rate detecting device is used for detecting the glomerular filtration rate of the patient according to the basic patient information collected by the patient information collecting terminal and the serum creatinine level detected by the serum creatinine detecting terminal. The detecting system provided by the invention can be used for simply and directly supplying an accurate glomerular filtration rate result to a doctor and the patient and the burden of the patient is relieved.

The present disclosure relates to systems and methods for determining the renal glomerular filtration rate or assessing the renal function in a patient in need thereof. The system includes a computingdevice, a power supply, one or more sensors, and at least one tracer agent that fluoresces when exposed to electromagnetic radiation. The electromagnetic radiation is detected using the sensors, andthe rate in which the fluorescence decreases in the patient is used to calculate the renal glomerular filtration rate in the patient.

A new method of in vitro monitoring and assessing the need of a medication which interferes with the regulation of the parathyroid hormone level in a kidney patient subject to oxidative stress, notably hemodialysis patients. FIG. 1 shows the distribution of n-oxPTH concentrations in 340 hemodialysis patients (224 men and 116 women) with a median age of 66 years (IQR, 56 to 75 years), a median time since initiation of dialysis (dialysis vintage) of 266 days (IQR, 31 to 1209 days), and a median dialysis dose (kt / V) of 1.2 (IQR, 1.1 to 1.3). The cause of chronic kidney disease was nephrosclerosis in 113 cases (33%), diabetic nephropathy in 107 cases (31%), chronic glomerular nephritis in 29 cases (9%), polycystic kidney disease in 9 cases (3%) and other / unknown in 82 cases (24%). The median n-oxPTH concentration was 5.9 ng / L (IQR, 2.4 to 14.0 ng / L). n-oxPTH concentrations were not different in men and women (5.9 ng / L; IQR, 2.4 to 14.2 ng / L; n=224; vs. 5.5 ng / L; IQR, 2.4 to 14.0 ng / L; n=1 16; p=0.915).

The invention relates to a method for reproducing paraffin sections from kidney biopsy immunofluorescence frozen residual tissues, which comprises the following steps: quickly unfreezing the frozen residual kidney tissues by using a PBS buffer solution, dissolving OCT (Optical Coherence Tomography) gel, reproducing the paraffin sections, carrying out special dyeing by using the paraffin sections,and carrying out light microscope examination to obtain the paraffin sections toooooooo make up the condition that no glomerulus exists or the glomerulus is too little in the light microscope examination. The method has the advantages that the steps are simple, the operation is fast and convenient, the dyeing effect is good, the secondary kidney biopsy of the patient can be effectively avoided, and the pain and the economic burden of the patient are reduced.

The invention relates to a pure traditional Chinese medicine preparation for treating glomerular diseases. The pure traditional Chinese medicine preparation is prepared from the following raw materials in parts by weight: 30 parts of membranous milkvetch root, 12 parts of amur corktree bark, 15 parts of rhubarb, 40 parts of glabrous greenbrier rhizome, 20 parts of radix salviae miltiorrhizae, 15 parts of oriental waterplantain rhizome, 20 parts of epimedium herb, 15 parts of lalang grass rhizome and 30 parts of motherwort herb, and prepared by decoction, filtration, concentration of filtrate and drying. The pure traditional Chinese medicine preparation has significant efficacy for kidney diseases comprising acute and chronic glomerulonephritis, nephrotic syndrome, hypertensive nephropathy, diabetic nephropathy and early renal insufficiency caused by various reasons; furthermore, the raw materials are easily available, the production process is simple, the toxicity and side effects are small, and the administration is convenient, thereby providing the effective pure traditional Chinese medicine preparation for treating the kidney diseases.

Disclosed is a Chinese medicinal formulation for treating chronic glomerular nephritis wherein the recipe includes eucommia bark 15g, nutgrass flatsedge rhizome 15g, psoralea fruit 15g, Achyranthes bidentatae 15g, pig's kidney 2 pieces, notoginseng 30g and astragalus root 20g. The medicament is prepared through conventional processes with easy accessibility of raw materials, simplified formulation and preparing procedures, and low cost of medicament production.

This invention provides a compound of formula (I):or a crystalline form thereof, or a pharmaceutical composition thereof, or an oral pharmaceutical dosage form thereof; processes for the synthesis or manufacture of the compound of formula (I), or a crystalline form thereof, or a pharmaceutical composition thereof, or an oral pharmaceutical dosage form thereof; and the use of said compound, or a crystalline form thereof, or a pharmaceutical composition thereof, or an oral pharmaceutical dosage form thereof, for the treatment of patients suffering from or subject to diseases, disorders or conditions involving cell survival, proliferation, and migration, including cardiovascular disease (e.g., arteriosclerosis and vascular reobstruction), cancer, (e.g., AML and malignant glioma) glomerulosclerosis, fibrotic disease and inflammation.

Measuring the number of glomeruli in the entire, intact kidney using non-destructive techniques is of immense importance in studying several renal and systemic diseases. In particular, a recent Magnetic Resonance Imaging (MRI) technique, based on injection of a contrast agent, cationic ferritin, has been effective in identifying glomerular regions in the kidney. In various embodiments, a low-complexity, high accuracy method for obtaining the glomerular count from such kidney MRI images is described. This method employs a patch-based approach for identifying a low-dimensional embedding that enables the separation of glomeruli regions from the rest. By using only a few images marked by the expert for learning the model, the method provides an accurate estimate of the glomerular number for any kidney image obtained with the contrast agent. In addition, the implementation of our method shows that this method is near real-time, and can process about 5 images per second.

The invention combines the polypeptide donkey-skin gelatins with different weight-average molecular weights and then adds tryptophan into the combined polypeptide donkey-skin gelatins to prepare the plasma substitutes containing gelatin molecules with different molecular weights. The process has the advantages that: smaller molecules can easily pass through renal glomerulus, which contributes to diuretics at the early stage of introduction; bigger molecules are left in the blood vessels, and the dilatation effect is prolonged; and the increase of the tryptophan can stimulate the synthesis of albumins so as to replenish the plasma proteins in huge loss.

The invention relates to the technical field of medicine. The clinical manifestations of glomerulonephritis are proteinuria, hematuria, edema, hypertension, etc. Among them, chronic glomerulonephritis has a long course of disease, often has different degrees of renal function damage, and has recurrent attacks, and the prognosis is poor. The purpose of the present invention is to provide the application of Clary sage extract in the preparation of medicine for treating glomerulonephritis. The invention provides an extract of sage ganxie obtained by drying and pulverizing medicinal materials of the roots of sage ganxie, soaking them in water-containing lower alcohol, extracting by percolation or heating, and concentrating and drying the extract. The above-mentioned Clary Sage extract has been confirmed by animal experiments to significantly reduce the urinary protein content of serum sickness glomerulonephritis model rats, and can significantly reduce the swelling of the glomerulus, and also has the ability to reduce blood viscosity and diuresis. therapeutic effect. The invention not only provides a new application for the ganxi sage, but also provides a new treatment drug for the majority of nephritis patients.

The invention provides a traditional Chinese medicinal preparation for treating chronic renal disease and a preparation method thereof. The traditional Chinese medicinal preparation is prepared from the following crude medicines in parts by weight: rheum officinale and safflower on (1-10):(10-1); the crude medicines are prepared into an injection, a freeze-dried powder injection or other oral preparations through certain extraction and purification processes. Animal experiments prove that the traditional Chinese medicinal preparation can be used for significantly improving the hemorheology indexes of mice infected by chronic glomerulonephritis and reducing serum IL-6, IL-8 and TNF-alpha levels; the preparation can be used for remarkably reducing serum urea nitrogen and serum creatinine contents of mice of chronic renal failure and increasing a serum albumin content; moreover, the preparation can be used for improving the various hemorheology indexes and levels of mice of chronic renal failure; a pathological result shows that the traditional Chinese medicinal preparation disclosed by the invention can be used for improving and inhibiting damage of chronic kidney disease and chronic renal failure on kidney; furthermore, the traditional Chinese medicinal preparation prepared by the optimal preparation method disclosed by the invention is more excellent than a traditional Chinese medicinal preparation prepared by a conventional method.

The invention provides a traditional Chinese medicine composition for treatment of chronic renal diseases and chronic renal failure and its preparation method. The traditional Chinese medicine composition is prepared from the raw material medicines of rheum officinale and salvia miltiorrhiza in a weight ratio of 1-10:10-1 by a certain extraction and purification process into an injection, a freeze-dried powder injection or other oral preparations. Animal experiments confirm that, the traditional Chinese medicine composition can obviously improve the hemodynamic indexes of rats subjected to chronic glomerulonephritis, reduces serum IL-6, IL-8, and TNF (tumor necrosis factor)-alpha levels, significantly reduces serum urea nitrogen and serum creatinine contents of rats subjected to the chronic renal failure, increases serum albumin content, and also can improve each hemodynamic index of rats subjected to the chronic renal failure; pathological results show that the traditional Chinese medicine composition can improve and inhibit injures on kidney caused by the chronic renal diseases and chronic renal failure; and the treatment effect of the traditional Chinese medicine preparation prepared by the preparation method provided by the invention is better than that of a traditional Chinese medicine preparation prepared by a conventional method.

The invention aims to solve the problem of cleaning nephritic lesion to clean the renal glomerulus effectively and thoroughly, and restore the functions of the renal glomerulus, clear renal calculus, and cure uremic patients and 290, 000 sufferers from the melamine tainted milk incident. The technical proposal of the invention comprises: cleaning the nephritic lesion by supplying photo-catalytic nanometer active water to the sufferers by drinking, injecting and targeting; and using the oxygenolysis capacity of free radicals in the photo-catalytic nanometer active water to clean the glomerular filtration membrane and the renal tubule effectively and thoroughly, decompose immune complexes or organic complexes deposited thereon, and diminish inflammation simultaneously so as to restore the functions of the renal glomerulus, establish an artificial immune system, and cure the uremia, nephritis, and the like. Simultaneously, the invention is a pioneering invention, the basic theory for the naissance of free radical physics, free radical chemistry and free radical medicine, and a mark for the naissance of new disciplines, and opens up a new era for the development of the human society. The photo-catalytic nanometer active water can be produced by solar energy, has low cost and is easy to widely popularize and apply.